Journal articles on the topic 'Dorsale de Mohn'

Berkeley and Helmholtz proposed different indirect mechanisms for size perception: Berkeley, that size was conditioned to various cues, independently of perceived distance; Helmholtz, that it was unconsciously calculated from angular size and perceived distance. The geometrical approach cannot explain size-distance paradoxes (e.g., moon illusion). The dorsal/ventral solution is dubious for close displays and untestable for far displays.

Atypical fibroxanthoma (AFX) is a rare cutaneous ulcerative lesion with a good prognosis. Diagnosis is difficult and is usually made by exclusion from pleomorphic dermal sarcoma and squamous cell carcinoma. Definitive treatment varies from Mohs micrographic surgery to wide local excision. We present a case of 76-year-old woman with AFX over the dorsum of her left hand. The tumour was excised and the resulting defect was reconstructed with a local second dorsal metacarpal artery perforator flap.

AbstractThe flight activity of each of the three major leafhopper vectors of rice tungro viruses, Nephotettix virescens (Distant), N. nigropictus (Stål) and Recilia dorsalis (Motschulsky) was closely associated with rice cropping periods and was influenced by crop growth stage and season. Leafhopper flight was influenced by changing levels of illumination at dusk and dawn and, for R. dorsalis only, was significantly affected by moon phase. Recilia dorsalis was the dominant species caught in suction traps at 0.75 m and 1.5 m and an upwardly-directed light trap at 4.0 m, whereas N. virescens was the most abundant species caught on sticky yellow traps at the height of the canopy. Infectivity tests on migrant leafhoppers caught in upwardly-directed light traps showed that N. virescens was the most common transmitter of rice tungro viruses. Infective leafhoppers were recorded at the end of dry seasons and during wet seasons in 1991 and 1992. The risk of tungro disease incidence was very low early in the 1991 dry season, when aerial abundance of leafhoppers was small and no infective individuals were recorded.

One Of the imprfant commercial spice-cum vegetable crop, Chilli (Copsicum annuml i' cultivohd Over o substantial area in the southern districts Of Tamil Nadu, Where insect pests are a serious problem. Among them the sucking pests, namely, the Thrips, (Scirtothrips dorsalis), the aphids (Aphis gossypii gnd Myzus persicoe) lotus) cause Over 50 per cent reduction in yield. Earlier, more weightage had been given fo insecticides both contact and sy*micto manage these pests (Raiasri etc'. , 991 Thakare etal., 992, Misra 1992., Jaganath, 1993. , Chendete and Desh-pande 1984, Jagan mohan et 01. , 1980., Kareernet d, 1977.,Mote 1977 and Roo ond Ahamed, 1986).

Notch signaling mediates numerous developmental cell fate decisions in organisms ranging from flies to humans, resulting in the generation of multiple cell types from equipotential precursors. In this paper, we present evidence that activation of Notch by its ligand Serrate apportions myogenic and non-myogenic cell fates within the early Xenopus heart field. The crescent-shaped field of heart mesoderm is specified initially as cardiomyogenic. While the ventral region of the field forms the myocardial tube, the dorsolateral portions lose myogenic potency and form the dorsal mesocardium and pericardial roof (Raffin, M., Leong, L. M., Rones, M. S., Sparrow, D., Mohun, T. and Mercola, M. (2000) Dev. Biol., 218, 326–340). The local interactions that establish or maintain the distinct myocardial and non-myocardial domains have never been described. Here we show that Xenopus Notch1 (Xotch) and Serrate1 are expressed in overlapping patterns in the early heart field. Conditional activation or inhibition of the Notch pathway with inducible dominant negative or active forms of the RBP-J/Suppressor of Hairless [Su(H)] transcription factor indicated that activation of Notch feeds back on Serrate1 gene expression to localize transcripts more dorsolaterally than those of Notch1, with overlap in the region of the developing mesocardium. Moreover, Notch pathway activation decreased myocardial gene expression and increased expression of a marker of the mesocardium and pericardial roof, whereas inhibition of Notch signaling had the opposite effect. Activation or inhibition of Notch also regulated contribution of individual cells to the myocardium. Importantly, expression of Nkx2. 5 and Gata4 remained largely unaffected, indicating that Notch signaling functions downstream of heart field specification. We conclude that Notch signaling through Su(H) suppresses cardiomyogenesis and that this activity is essential for the correct specification of myocardial and non-myocardial cell fates.

Abstract Long-term, adult-engrafting hematopoietic stem cells (HSC) first emerge from hemogenic endothelial (HE) precursors in the context of embryonic arterial vessels such as the dorsal aorta of the AGM (Aorta-Gonad-Mesonephros region), a process which requires Notch1 receptor signaling. However, a possible subsequent role for Notch receptor activation during the unique period of substantial HSC expansion in embryonic development remains less well defined. Here, we show that endothelial cells derived from the murine embryonic AGM region (AGM-EC) or fetal liver (FL-EC) provide an in vitro substrate for generation/maturation of HSC from HE/HSC-precursor populations derived from early stage murine embryos, which lack adult-engraftment capacity prior to co-culture. Notably, these EC substrates, endogenously expressing Notch ligands of the Jagged and Delta families, also support subsequent numerical expansion of AGM-derived HSC, expressing Notch1 and Notch2 receptors, as determined by limit dilution transplantation analysis. Consistent with a requirement for Notch activation in this process, phenotypic HSC expansion during EC co-culture is blocked by gamma-secretase mediated Notch pathway inhibition. Furthermore, we show that in vitro Notch activation by immobilized ligand Delta1, together with cytokines and inhibition of the TGF-beta pathway, is sufficient to increase the number of AGM-derived HSC in the absence of EC stroma. Expansion of phenotypic hematopoietic stem/progenitor cells generated by culture on Delta1 is inhibited by antibody-mediated blockade of the combination of Notch1 and Notch2, but not by either Notch1 or Notch2 alone. Consistent with this, Notch receptor-specific activation by either immobilized Notch1 or Notch2 antibody is sufficient to support AGM-derived HSC in vitro in preliminary experiments. Altogether, these studies suggest a role for Notch pathway activation by either Notch1 or Notch2 in supporting embryonic-stage HSC expansion subsequent to initial Notch1-mediated HSC specification. Disclosures Moon: Fate Therapeutics: co-founder Other. Rafii:Angiocrine Biosciences: Founder Other.

The genus Antodice Thomson, 1864 was revised by Martins & Galileo (1998) and currently includes 27 species (Tavakilian & Chevillotte 2017), distributed from Mexico to southern South America. Based on a single female specimen collected in Arroyo Cristal, Ka'azapá, Paraguay, the species Antodice quadrimaculata was first described by Martins & Galileo in 2003. The holotype specimen was collected on 20 November 1999 by J. Jensen and is deposited in the Museum of Zoology of the University of São Paulo, Brazil. With the help of Carlos Aguilar, from Paraguay’s National Museum of Natural History, we were able to determine the exact location where the holotype was collected. With the collection and the description of the male, presented herein, we describe the male of this species record its occurrence in Brazil, a new country record.We identified this species as belonging to the group of Antodice species with yellowish flagellomeres and a black apex, resembling Antodice venustula Lane, 1973 in its elytral color pattern. In A. venustula, the elytra are covered with whitish pubescence and exhibit only two patches of compact white pubescence. In A. quadrimaculata, according to Martins & Galileo (2003), the elytra are of a reddish color with whitish pubescence on the dorsal anterior area and close to the apexes, and they also have three patches of compact white pubescence. The specimens of A. quadrimaculata cited herein were collected in the Iguaçu National Park (Parque Nacional do Iguaçu—PNI), the largest fragment of Atlantic forest in southern Brazil, located in the western region of the state of Paraná. The insects were collected using light traps, set up on nights with a new moon. The artificial light source was a 500-Watt incandescent lamp powered by a Honda EP 2500 generator. Sampling began at 6 p.m., ending between midnight and 3 a.m. the next day. The studied material was deposited in the entomological collection of the Museum of Zoology at the State University of Londrina (Universidade Estadual de Londrina), Londrina, Brazil (MZUEL). To better represent the expansion of the geographical distribution of the species from the holotype recorded in Paraguay (Fig. 5, 6), the cartographic material (Fig. 1) was produced using ArcGIS Software 9.0®. The map database was obtained from the Institute of Land, Cartography and Geosciences, (Instituto de Terras, Cartografia e Geologia do Paraná), Curitiba, Brazil (ITCG).

Abstract Background: Cushing syndrome (CS) is well known to be associated with metabolic syndrome, venous thromboembolism, hypertension, left ventricular hypertrophy, and rarely dilated cardiomyopathy. The pathophysiological effects of hypercortisolism on the myocardium results in cardiomyocyte hypertrophy, myofibrillolysis, myocardial fibrosis, global longitudinal and circumferential strain. Our patient presents an example of CS in the setting of chronic heart failure with reduced ejection fraction, multiple thromboembolic events, and diabetes mellitus in a young adult. Clinical Case: A 34-year male with a past medical history of dilated cardiomyopathy with biventricular failure and left ventricle ejection fraction of 10%, pulmonary embolism, diabetes mellitus, and gout presented with shortness of breath. On physical exam he presented with symptoms of CS: moon facies, supraclavicular fat pads, dorsal fat pads, purple striae of abdominal skin, truncal obesity, ecchymosis, and skin atrophy. Labs showed elevated morning cortisol after overnight 1 mg dexamethasone suppression test (cortisol 8.6 mcg/dl, n< 5 mcg/dl), repeat morning cortisol after overnight 1 mg dexamethasone suppression test (cortisol 5.7 mcg/dl, n< 5 mcg/dl), and ACTH-concentrations <5 pg/ml. CT-scan was insignificant for adrenal hyperplasia. He was admitted and treated for acute congestive heart failure exacerbation with plans for definitive treatment of CS outpatient with further imaging studies. Conclusion: The occurrence of CS induced heart failure results in increased mortality. There have been numerous accounts of resolution of cardiomyopathy after surgical treatment for CS secondary to adrenal adenoma. Our patient had a 10-year history of chronic dilated cardiomyopathy prior to cushingoid symptoms and confirmatory endocrinological data. The definitive treatment for CS syndrome in our patient would eventually be surgery targeting the source of hypercortisolism, however his cardiovascular risk factors would make him a poor surgical candidate. Severely reduced ejection fraction is a contraindication for generalized anesthesia needed for surgery. When surgery is contraindicated in CS medical management is recommended according to guidelines that target pituitary-directed medical treatments for Cushing’s disease and targeted therapies to treat ectopic ACTH syndrome. To our knowledge there have been few studies that demonstrate the effects of CS treatment on chronic conditions such as dilated cardiomyopathy. Studies have shown that surgical treatment for CS have reversed cardiomyopathy caused by CS but it still remains to be answered whether this same effect is achieved to some degree in chronic dilated cardiomyopathy.

AbstractVery little is known about the ecology and biology of the smallest marine vertebrates, fishes in the genus Schindleria. Even though over half of named Schindleria species have been identified in the Red Sea, the collection of only very few specimens has been documented. Here, we assessed abundance patterns of nearly two thousand Red Sea long dorsal fin (LDF) adults and found evidence for putative seasonal and spatial differences, likely related to differing habitat and environmental conditions. The highest abundances were outside local seasonal temperature extremes and decoupled from peaks of coral reef fish recruitment. We also found evidence for global trends in abundances related to lunar cycles using our Red Sea data and that from a recently published large collection of specimens from the DANA Expedition (1928–1930). The abundance of adult LDF Schindleria in relation to lunar phases differed significantly, with most Schindleria caught outside the full moon, and mostly during the new moon in the Red Sea and the 3rd quarter moon in the DANA collection. We further suggest that the abundances of Schindleria at coral reefs may be related to reproductive cycles and that these cycles may be timed with the moon as back-calculations of hatch dates from otoliths from the Red Sea significantly resulted after the new moon, making Schindleria the fastest-lived coral reef fish with the shortest generation times. Schindleria could be the most numerous coral reef fish in the world, for which we encourage increased research.

Abstract Introduction: Typical ACTH-producing pituitary adenomas are benign tumors, microadenomas, successfully treated by neurosurgery. However, 10-20% of Cushing’s disease (CD) patients have macroadenomas, sometimes invasive and aggressive cases with poorer surgical prognosis needing additional approaches. Temozolomide (TMZ), second generation alkylating agent, has been used alone or in combination to other medications/radiotherapy (RTX) for tumor control of aggressive pituitary adenomas and carcinomas. We report one patient with giant aggressive corticotropinoma that presented control tumor with RTX and TMZ after four pituitary surgeries unable to uncontroll tumor growth. Clinical Case: A 18-year-old female patient presented with weight gain, red moon face, supraclavicular fullness, dorsal hump, large purple striae, acanthosis nigricans, secondary amenorrhea, frontotemporal headache, visual impairment and right palpebral ptosis. Hormonal analysis confirmed ACTH-dependent Cushing's syndrome. Pituitary MRI showed the presence of a large selar and suprasellar expansive lesion of 5.2X5.1X4.0 cm with displacement of third ventricle, hypothalamus and lateral ventricles. The patient was submitted to the first neurosurgery (transsphenoidal route) with partial resection. Pathological analyses confirmed pituitary adenoma positive for ACTH, Ki-67 8%, negative p53 and 7 mitoses/10 field of great increase. Subsequent surgery was done by craniotomy with partial resection. Cabergoline 2 mg/week was started but the tumor keeps growing with worsening of visual complaints and increase of cortisol levels. At admission in our center, we planned new surgeries do remove the maximal tumor possible (debulking) and subsequent RTX and TMZ. She was submitted to third surgery by transsphenoidal route and the last surgical procedure by craniotomy. MRI pre-RTX done three months after the 4th surgery showed remnant tumor of 3.5X3.0X3.0 cm. Fractioned stereotaxic radiotherapy was done with linear accelerator in a total of 54 Gy divided in 30 sessions. TMZ was initiated in a dose of 150 m2/day, cycles of five days/month, using for 14 months. Pituitary MRI 3, 6 and 10 months after TMZ showed a small reduction of tumor with increase of intratumor cystic areas. Conclusion: The combined use of TMZ and radiotherapy is an important approach for the treatment of rapidly growing, aggressive pituitary ACTH-secreting tumors resistant to conventional treatment.

Ophiolites are complex assemblages of ultramafic and mafic igneous rocks that are now widely considered to be pieces of ancient oceanic crust that were emplaced on to the continents courtesy of global plate tectonics. However, most examples were originally considered parts of enormous layered mafic intrusions and so were interpreted in that light. The new understanding of ophiolites in the late 1960s and early 1970s was a crucial part of the global Earth Science revolution, and they are now central to all plate tectonic models developed for ancient orogenic belts. Although their equivalence to oceanic crust is now well established, many ophiolites may not be ‘typical’ examples of such, and not all examples are identical. Most ophiolites likely formed in subduction-influenced environments rather than at mid-ocean ridges. Ophiolites remain important foci for research in the 21st century, and many questions remain about their environments of formation and especially their mechanisms of emplacement onto the continents. Although it was not the first to be seen as a relic of a vanished ocean, the Bay of Islands Igneous Complex in western Newfoundland is one of the best preserved and most easily accessible ophiolites in the world. In the late 20th century, research work in this area proved highly influential in understanding the oceanic crust, and in unravelling the diachronous events involved in the progressive destruction of an ancient stable continental margin as arcs and microcontinental blocks were accreted along it. Parts of the Tablelands Ophiolite lie within Gros Morne National Park, which is a UNESCO world heritage site because of its importance to our understanding of global tectonics. The wider region around the park also includes the Cabox Aspiring Geopark Project, now also in the process of seeking recognition through UNESCO. This article provides background information on ophiolites and the development of our ideas about them, and links this material to four self-guided field excursions that allow examination of many classic features. These excursions range from a collection of roadside outcrops, to some relatively easy hiking excursions on official National Park trails, and eventually to a more challenging off-trail hike that ascends to the summit plateau of the Tablelands to visit rare exposures of the Moho (the Mohorovičić Discontinuity, i.e. the lower boundary of the Earth’s crust) and the underlying upper mantle rocks. Collectively, the field stops should allow geologically-minded visitors to experience some amazing geology in a spectacular and sometimes surreal landscape. RÉSUMÉLes ophiolites sont des assemblages complexes de roches ignées ultramafiques et mafiques qui sont maintenant généralement considérées comme des fragments de croûte océanique ancienne qui ont été charriés sur les continents grâce à la tectoniqueglobale des plaques. Cependant, la plupart des exemples étaient à l'origine considérés comme faisant partie de vastes intrusions mafiques stratifiées et ont donc été interprétés dans ce contexte. La nouvelle compréhension des ophiolites à la fin des années 60 et au début des années 70 a été un élément crucial de la révolution des sciences de la Terre. Les ophiolites sont désormais au coeur de tous les modèles tectoniques des plaques développés pour les anciennes ceintures orogéniques. Bien que leur équivalence avec la croute océanique soit maintenant bien établie, de nombreuses ophiolites peuvent ne pas en être des exemples « typiques », et tous les exemples ne sont pas identiques. La plupart des ophiolites se sont probablement formées dans des environnements influences par la subduction plutôt qu’au niveau des dorsalis océaniques. Les ophiolites restent un thème de recherché important au XXIe siècle et de nombreuses questions subsistent quant à leurs environnements de formation et notamment à leurs mécanismes de mise en place sur les continents. Bien qu'il n’ait pas été le premier à être identifié comme un vestige d'un océan disparu, le complexe igné de la baie des Îles, dans l'ouest de Terre-Neuve, fait partie des ophiolites les mieux conservées et les plus facilement accessibles au monde. À la fin du XXe siècle, les travaux de recherche dans ce domaine ont joué un rôle déterminant dans la comprehension de la croûte océanique et dans la compréhension des événements diachrones impliqués dans la destruction progressive d'une ancienne marge continentale stable au fur et à mesure de l'accrétion d'arcs et de blocs microcontinentaux. Une partie des Tablelands Ophiolite se trouve dans le parc national du Gros-Morne, site classé au patrimoine mondial de l'UNESCO en raison de son importance pour notre compréhension de la tectonique globale. La région plus large autour du parc comprend également le projet Cabox Aspiring Geopark, qui est également à la recherche d’une reconnaissance dans le cadre de l’UNESCO. Cet article fournit des informations de base sur les ophiolites et le développement de nos idées à leur sujet, et relie ce matériel à quatre excursions autoguidées qui permettent d'examiner de nombreuses caractéristiques classiques. Ces excursions vont d’une collection de visites d’affleurements au bord de la route, à des randonnées relativement faciles sur les sentiers officiels du parc national, et finalement à une randonnée plus difficile hors-piste menant au plateau sommital des Tablelands pour visiter de rares affleurement du Moho (la discontinuité de Mohorovičić, c’est-à-dire la limite inférieure de la croûte terrestre) et des roches du manteau supérieur sousjacentes. Collectivement, les visites sur le terrain devraient permettre aux visiteurs amateurs de géologie de faire l'expérience d'une géologie remarquable dans un paysage spectaculaire et parfois surréaliste.