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Dissertations / Theses on the topic 'Dosage formulation'

Author: Grafiati

Published: 20 February 2023

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1

Buys, Johannes Jacobus. "Formulation and evaluation of mebendazole dosage forms / Kobus Buys." Thesis, North-West University, 2003. http://hdl.handle.net/10394/190.

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Parasites in the restricted sense are those members of the animal kingdom which derive their means of well-being from other members of the animal kingdom, at the same time depriving their host of some (sometimes all) of its well-being. Parasitic diseases are much more widespread than many people realise. These diseases affect not only impoverished people in remote countries but they can be important health problems for rich and poor throughout the world. Different parasites infect our domestic animals and cause great losses; they have a great influence on the growing, production and overall re

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2

Palazzolo, Robert D. (Robert David) 1973. "Formulation of oral dosage forms by three dimensional printing." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50617.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1998.<br>Includes bibliographical references (p. 93).<br>Pharmaceutical grade materials were used in the fabrication of fast-release and extended-release oral dosage forms. Tablets were processed by employing a method of solid freeform fabrication known as three dimensional printingTM (3DPTM). A microcrystalline cellulose powder was used in combination with pH-dependent and permeable polymeric binder solutions. Release studies in acidic media were performed using both dye and drug (antihistamine)

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Injety, Sahana. "Formulation of a nevirapine co-crystal as a liquid dosage form." University of the Western Cape, 2016. http://hdl.handle.net/11394/5060.

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Magister Pharmaceuticae - MPharm<br>Co-crystals are a solid phase phenomena that could enhance the physicochemical properties of an active pharmaceutical ingredient. A co-crystal has never been incorporated into a liquid dosage form with the assurance of maintaining its co-crystal state until absorption under defined conditions. This study aims to develop a liquid formulation with a nevirapine co-crystal. A protocol was developed to investigate all the five co-formers that were used to make the nevirapine co-crystals to-date. The most appropriate co-former was selected for a liquid dosage form

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4

Raiwa, Araya [Verfasser]. "Formulation development strategies for oral extended release dosage form / Araya Raiwa." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025490363/34.

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5

Wheate, Nial. "Pharmaceutical Drug Design, Formulation, Testing, and Use." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22097.

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This compilation of my research has been organised into nine different sections based on the sub-themes on my research into medicines. Section one deals principally with my research and impact into the examination of the interactions of multinuclear platinum-based chemotherapy drugs with their cellular target, DNA. Section two covers the design and synthesis of new drugs including multinuclear platinum drugs and a new drug class of platinum drugs based on phenanthroline. Section three details my investigation of macrocycles as potential delivery vehicles for drugs; in particular, the deli

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6

Owaisat, Suzan. "A novel oral dosage form with drug independent formulation and variable controlled release." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/342831.

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Pharmaceutical Sciences<br>Ph.D.<br>A unique dosage form which uses a hydrophilic polymer was developed to provide for a predicable release of several drugs. This drug release could be optimized for controlled release using erosion. It can also be designed to release drug utilizing electrochemical processes. The accuracy of drug delivery in terms of dose and timing is of utmost importance for the patient’s health status and compliance. A well-designed drug delivery technology offers many advantages to the patient. These advantages include: reduction in dose frequency, reduction of drug side ef

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7

Bohloko, Ntseliseng Selloane. "Development and formulation of an intranasal dosage form for cyclizine hydrochloride / Ntseliseng Selloane Bohloko." Thesis, North-West University, 2004. http://hdl.handle.net/10394/403.

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A comprehensive review of the nasal route of administration, in particular the nasal drug delivery system has been presented. The physicochemical properties, mode of action and pharmacology of H1-receptor antagonists, in particular cyclizine HCl, have been highlighted. The techniques for the assessment of toxicity (in-vitro ciliary beat frequency (CBF) studies for human nasal explants and morphology studies of the rat nasal mucosa), synthesis of cyclizine lactate, solubility studies of both cyclizine HCI and cyclizine lactate, viscosity determination of the gel formulated and assessment of the

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8

Gu, Alice. "Development of a Cucurbituril Suspension-Based Dosage Formulation and its Ability to Taste Mask Paracetamol." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25943.

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Medication non-adherence as a result of aversion to the bitter taste of active pharmaceutical ingredients and/or an inability to swallow solid dosage forms presents a challenge to the optimal use of medicines. The aims of this study were to examine the interactions of cucurbit[n]urils (CB[n]; n = 6, 7, 8) with paracetamol, and CB[7] with common pharmaceutical excipients, to design an effective oral suspension dosage formulation with CB[n]s as a potential taste masking excipient, and to assess the ability of CB[7] to reduce the bitter taste of paracetamol in rats. 1H NMR spectrometry was used t

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9

Hamid, Rezaei. "EFFECT OF MOLECULAR WEIGHT OF POLYETHYLENE GLYCOLS ON THEIR FUNCTION AS LUBRICANT SPARING BINDERS IN TABLET TECHNOLOGY." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin984508148.

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10

Marais, Johannes Francois. "The formulation of different dosage forms with the anthelmintics : Levamisole, Niclosamide and Oxyclozanide / J.F. Marais." Thesis, North-West University, 2003. http://hdl.handle.net/10394/390.

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Different formulations of dosage forms of niclosamide, levamisole HCI or levamisole HCI and oxyclozanide have been used on the local market for a very long time. Unfortunately, the spectrum of each of the drugs alone has a very narrow therapeutic index. Together, however, they have a broad spectrum of action and it is a solution to most of the helminths infestations today. Because of the increasing cost to produce livestock, it is important to formulate a product that is not only pharmacologically effective but also cost effective. A combination dosage form plays a big role in decreasing the c

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11

Komperlla, Mahesh Kumar. "The formulation and evaluation of rapid release tablets manufactured from Artemisia Afra plant material." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

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<p>Infusions, decoctions, alcoholic preparations and other dosage forms of Artemisia afra are frequently used in South African traditional medicine. Generally when these preparations are made without applying good manufacturing practices they do not meet microbial quality control standards, safety and toxicity criteria and encourage poor patients compliance. To overcome the aforementioned disadvantages of traditional dosage forms a sold dosage form, i.e. a table might be recommended. The first objective of this study was to formulate and manufacture a rapid release tablet dosage of Artemisia a

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12

Buys, Gerhardus Martinus. "Formulation of a chitosan multi-unit dosage form for drug delivery to the colon / G.M. Buys." Thesis, North-West University, 2006. http://hdl.handle.net/10394/1687.

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13

Maniruzzaman, Mohammed. "Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms." Thesis, University of Greenwich, 2012. http://gala.gre.ac.uk/9812/.

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Hot-melt extrusion (HME) is one of the most widely used technologies in the plastic, rubber and food industries and it has also been extensively explored and used in academia and the pharmaceutical industry over the last decade. This project aims to investigate the efficiency of hydrophilic polymers to enhance the dissolution rate of poorly water-soluble APIs processed by HME. Indomethacin (INM) and famotidine (FMT) were selected as model active substances while polyvinyl caprolactam graft copolymer, Soluplus® (SOL) and vinylpyrrolidone-vinyl acetate copolymer grades Kollidon® VA64 (VA64) and

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14

Seshadri, Madhumathi. "Formulation and Investigation of Specialised Dosage Forms for the Systematic Delivery of the Selective Antineoplastic a-Tocopheryl Succinate." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/365909.

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Background. a-Tocopheryl succinate, a redox-silent analogue of vitamin E, has been shown to selectively induce apoptosis in a variety of cancers. However, a-tocopheryl succinate is rendered ineffective when administered orally due to hepatic metabolism. Transdermal delivery has been identified as an alternative approach for delivering in-tact a-tocopheryl succinate systemically. Aims and objectives. The aim of this study was to compound a liposomal formulation of a-tocopheryl succinate and evaluate the transdermal diffusion in an in-vitro Franz diffusion cell assay. The feasibility of transde

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15

Kieser, Leith Faye. "Formulation and assessment of monolithic beta blocker sustained release tablets prepared by direct compression." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1003242.

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Beta blockers are commonly prescribed for the chronic treatment of hypertension, one of the most prolific disease states worldwide. The beta blockers selected for this study include acebutolol hydrochloride, labetalol hydrochloride, metoprolol tartrate oxprenolol hydrochloride and propranolol hydrochloride. All of these compounds have a short elimination half-life, necessitating multiple dose per day regimens and therefore the development of sustained release dosage forms incorporating these agents was considered beneficial in terms of extending the dosing interval, with the aim of improving p

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16

Pereira, Camelo Sarah Regina. "Encapsulation de molécules hydrophobes par des structures bi-gels générées par prilling : relation structure-propriétés." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2015. http://www.theses.fr/2015EMAC0002/document.

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Ce travail de thèse s’articule autour de la génération et de la caractérisation de capsules d’organo-hydrogel ou simplement bi-gels, obtenues par la technologie du prilling et destinées à la délivrance contrôlée d’un principe actif (P.A), après administration par voie orale. L’Efavirenz (EFV), un antirétroviral utilisé dans le traitement du VIH/Sida, a été le P.A utilisé comme modèle de molécule de faible solubilité dans l’eau. Il a été dissous dans l’organogel composé d’huile de tournesol et d’acide 12-hydroxystéarique (12-HSA). L’organogel a été caractérisé par sa température de transition d

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17

Chouchou, Adrien. "Développement préclinique de dérivés imidazo [1,2-a] quinoxaliniques à visée anticancéreuse : synthèse chimique, formulation galénique et validation de méthode de dosage en milieu biologique." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT034/document.

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Le projet concerne des molécules hétérocycliques, de faible poids moléculaire, présentant des activités cytotoxiques comparables à celles des meilleurs anticancéreux actuellement sur le marché. Ces molécules sont originales, protégées par un brevet international et un brevet de sélection déposé en décembre 2014. La synthèse des premières molécules leaders est maîtrisée et l’exemplification de la diversité moléculaire est en cours. Les études menées pour définir leur profil d’activité permettent d’identifier des caractéristiques tout à fait originales. Le projet, en phase de développement précl

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18

Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;<br>Ph.D.<br>The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gast

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19

Bredenberg, Susanne. "New Concepts in Administration of Drugs in Tablet Form : Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System." Doctoral thesis, Uppsala University, Department of Pharmacy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3433.

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<p>This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.</p><p>Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. By studying the relationship between disintegration time and tensile strength, it was found that the microstructure surrounding the disintegrant particles may influence the disintegration process. Therefore, avoidance of excipients which are highl

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20

Chaibva, Faith Anesu. "The use of response surface methodology and artificial neural networks for the establishment of a design space for a sustained release salbutamol sulphate formulation." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1010432.

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Quality by Design (QbD) is a systematic approach that has been recommended as suitable for the development of quality pharmaceutical products. The QbD approach commences with the definition of a quality target drug profile and predetermined objectives that are then used to direct the formulation development process with an emphasis on understanding the pharmaceutical science and manufacturing principles that apply to a product. The design space is directly linked to the use of QbD for formulation development and is a multidimensional combination and interaction of input variables and process p

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21

Berrabah, Mohammed. "Etude analytique de nanocapsules renfermant des substances de nature hydrophile. Influence de la vectorisation sur le métabolisme." Rouen, 1995. http://www.theses.fr/1995ROUES008.

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Les nouvelles formes galéniques permettant la vectorisation des principes actifs à l'état de suspension de nanocapsules peuvent entraîner des modifications du métabolisme des molécules ainsi administrées. Les nanocapsules étudiées ici sont constituées d'une paroi de polycaprolactone renfermant le benzoate de benzyle dans lequel est dissous le principe actif. Un contrôle analytique par CPG-SM couplée a été mis au point et validé. Il permet grâce à une méthode d'extraction différentielle, d'identifier le principe actif resté en solution, celui qui est encapsulé et celui qui se trouve plus au moi

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22

Laru, Katri Johanna. "Design of films for oral dosage formulations." Thesis, Aston University, 2009. http://publications.aston.ac.uk/15339/.

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A novel method for tablet coating was studied where a thin polymer film was cast (pre-formed film), dried and applied as a coating hence eliminating the need for using any solvent during the actual coating process. A pre-formed film is initially heating to a temperature where it becomes flexible, a vacuum is applied and the film is then pulled around the tablet. The proposed films (gelatine or cellulose-based) were characterised in terms of their dissolution, swelling, mechanical and thermal properties prior to using them in the novel coating process; selected films were then coated onto table

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23

Raines, Catherine Lindsay. "The extrusion of various formulations of microcrystalline celluloses." Thesis, University College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309626.

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24

Muthudoss, Prakash. "Application of FTIR imaging and spectroscopy to solid dosage formulations." Thesis, Sheffield Hallam University, 2011. http://shura.shu.ac.uk/20107/.

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The preparation of solid dispersions, in this study felodipine/polyvinyl pyrrolidone solid dispersion, is a multifaceted phenomenon. In order to understand the formation of solid dispersions two different mixed solvent system, three different temperatures and different drug loadings were selected and monitored in real time using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy. 50 mul of the prepared solution was placed onto a pre-heated ATR crystal. The effect of PVP/API ratio, molecular interactions and effect of temperature (30°C, 40°C and 50°C) on the rate o

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25

Meyer, Eric. "Comparative bioavailability and ranking of topical corticosteroid formulations." Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1001471.

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Numerous experiments in recent years have indicated differences in the bioavailability of corticosteroids from seemingly identical topical dosage forms. The human blanching assay was utilized in this study to assess the comparative blanching activities of various locally manufactured proprietary corticosteroid preparations. The first experiment was performed to assess the relative blanching activities of six semi - solid preparations containing the same concentration of betamethasone 17-valerate. The preparations used were Betnovate cream and ointment, Persivate cream and ointment and Celestod

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Chaw, Cheng Shu. "The gastric emptying and drug absorption of liquid formulations of 4-aminosalicylic acid." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327130.

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27

Magnus, Laura. "Development, assessment and optimisation of oral famciclovir formulations for paediatric use." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1018244.

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Many Active Pharmaceutical Ingredients (API) such as the antiviral agent famciclovir (FCV) are required for paediatric treatment but are not commercially available in age-appropriate dosage forms. It is common practice to prepare oral liquid dosage forms using commercially available tablets, capsules or powdered API and then dispersing or dissolving the crushed and/or powdered materials in a vehicle that the patient can swallow. Vehicles that are commonly used for this purpose include methylcellulose, syrup or combinations of these carriers where possible or commercially available suspending a

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Amorij, Jean-Pierre. "The development of stable influenza vaccine powder formulations for new needle-free dosage forms." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/305732021.

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Mollel, Happiness. "Development and assessment of azithromycin paediatric suppository formulations." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1345/.

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Sachikonye, Tinotenda Chipo Victoria. "Development and assessment of minocycline sustained release capsule formulations." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1013127.

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The use of minocycline for the treatment of a broad range of systemic infections and for severe acne has been associated with vestibular side effects. The severity of side effects may lead to poor adherence to therapy by patients. The use of sustained release formulations of minocycline that display slow dissolution of minocycline following administration may be beneficial in reducing the incidence and severity of side effects. Therefore, sustained release capsule dosage forms containing 100 mg minocycline (base) were manufactured and assessed for use as sustained release oral dosage forms of

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31

Hägerström, Helene. "Polymer gels as pharmaceutical dosage forms : rheological performance and physicochemical interactions at the gel-mucus interface for formulations intended for mucosal drug delivery /." Uppsala : Acta Universitatis Upsaliensis, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3538.

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32

Ong, Michael Lau Hui. "The aerosol performance and physico-chemical properties of co-milled dry powder formulations for high dose delivery." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16277.

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The overall aim of the thesis was to investigate the aerosol performance and physico-chemical properties of dry powder formulations produced by co-milling an Active Pharmaceutical Ingredient (API- Beclomethasone Dipropionate - BDP) with an additive (Magnesium Stearate - MGST), using the jet mill apparatus, for high dose delivery. Co-milled formulations were produced at the set concentration of 1% w/w BDP, varying concentrations of MGST (0%-7.5% w/w), adding lactose as the final bulking agent. In general, 5% w/w MGST was found to be the optimal concentration for aerosol performance in terms of

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33

Telford, Richard. "The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development." Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/10098.

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Active Pharmaceutical Ingredients (APIs) are frequently prepared for delivery to the lung for local topical treatment of diseases such as Chronic Obstructive Pulmonary Disease (COPD) and asthma, or for systemic delivery. One of the most commonly used devices for this purpose is the pressurised metered dose inhaler (pMDI) whereby drugs are formulated in a volatile propellant held under pressure. The compound is aerosolised to a respirably sized dose on actuation, subsequently breathed in by the user. The use of hydrofluoroalkanes (HFAs) in pMDIs since the Montreal Protocol initiated a move away

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Fazel, Mohammad, Paul Myrdal, and Poonham Sheth. "The Effect of Drug Formulation on in vitro Performance Indices for Metered-Dose Inhalers with Regards to Varying Mouth-Throat Models." The University of Arizona, 2013. http://hdl.handle.net/10150/614257.

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Class of 2013 Abstract<br>Specific Aims: To elucidate the effect of the use of three different inlet configurations, percent ethanol in formulation, and propellant used on the percent respirable drug and MMAD of aerosolized particles from MDIs that contained beclomethasone dipropionate (BDP). Methods: The inlet configurations assessed in this study were the United States Pharmacopeia (USP) throat, the Alberta idealized mouth-throat replica (biological throat), and a large volume spacer (globe). ACI analyses were conducted on four different MDI formulations with regards to each of the three

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Dennison, Thomas. "Orally disintegrating tablets : formulation development, novel engineering solutions and fixed dose combinations." Thesis, Aston University, 2017. http://publications.aston.ac.uk/30817/.

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Orally disintegrating tablets (ODTs) are an attractive solid dosage form for patients who suffer from dysphagia, a difficulty in swallowing, which is particularly prevalent in paediatric and geriatric populations. ODTs and fixed dose combination (FDC) formulations are popular as they improve patient compliance and combination of the two has not previously been explored. The requirement for ODTs to disintegrate rapidly whilst also being mechanically robust means that high drug loading is a significant challenge. An ODT formulation for the betalactam antibiotic flucloxacillin was developed at do

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Hägerström, Helene. "Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery." Doctoral thesis, Uppsala University, Department of Pharmacy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3538.

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<p>Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. This has been attributed to the rheological and mucoadhesive properties of the gel. The main objective of this thesis was to investigate the importance of these features for the anticipated in vivo contact time, here exemplified by the ocular and nasal routes of administration

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Laukamp, Eva Julia [Verfasser], Jörg [Akademischer Betreuer] Breitkreutz, and Peter [Akademischer Betreuer] Kleinebudde. "Melt Extruded Drug Formulations for Individual Dosing by the Solid Dosage Pen / Eva Julia Laukamp. Gutachter: Jörg Breitkreutz ; Peter Kleinebudde. Betreuer: Jörg Breitkreutz." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1069620157/34.

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Solik, Agnieszka Anna [Verfasser]. "Formulation Development of High Dose (-)-Epigallocatechin-3-gallate Immediate Release Tablets / Agnieszka Anna Solik." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1070218944/34.

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Chen, Yang. "The influence of device and formulation parameters on aerosol electrostatics for pressurised metered dose inhalers." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13568.

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The aim of this thesis was to investigate the fundamental elements that influence aerosol electrostatic charge and performance of pressurised metered dose inhalers (pMDI). This was achieved by focusing on both physical and chemical parameters of the pMDI system, including orifice materials, geometries and formulation parameters. The electrostatic charges generated from pMDIs were successfully quantified using a modified Electrical Low Pressure Impactor (ELPI) and the magnitude and polarity of aerosol charges were found to be dependent on the actuator materials, nozzle geometries and the formul

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Zhu, Bing. "THE INFLUENCE OF FORMULATION VARIABLES ON PARTICLES GENERATED FROM SOLUTION BASED PRESSURIZED METERED DOSE INHALERS." Thesis, The University of Sydney, 2013. http://hdl.handle.net/2123/9758.

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The main aims of this work were to investigate the aerosol performance, particle formation process and physico-chemical properties of particles produced from solution-based pressurized metered dose inhalers (pMDIs) formulated with different co-solvent concentrations. In addition, the influences of different active pharmaceutical compounds and glycerol as the non-volatile components were also evaluated. This thesis demonstrated the complex nature of particle formation in solution based pMDIs and investigated the influence of co-solvent (e.g. ethanol) and non-volatile additives (e.g. glycerol a

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Ooi, Jesslynn Stephanie. "The Determination Of Physical And Chemical Stability Of Pressurised Metered Dose Inhaler Formulations." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16276.

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The main aim of this body of work was to develop alternative physical property detection methods to probe drug propellant interactions. A secondary aim of this thesis was to understand if there was any association between the interaction of drug and propellant on a micro-scale with the key performance attributes of a metered dose inhaler. An isothermal calorimetry technique was developed to dose model propellant vapour and probe the surface of the API. This approach was taken to investigate the crystallization kinetics of two structurally dissimilar yet commonly utilized APIs, salbutamol sulph

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D'Sa, Dexter. "Accelerating development of suspension pressurized metered dose inhaler formulations: innovative techniques to evaluate particle stability." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13380.

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This thesis presents several innovative techniques to rapidly evaluate particle stability in suspension-based pressurized metered dose inhalers (pMDIs). Chapter 1 reviews techniques available to evaluate particle stability in pMDIs, discussing categories such as particle properties, suspension quality, polymorphism, and long term stability. Emerging techniques such as Liquid Colloidal Probe Microscopy (CPM), Nano X-ray Computer Tomography (NanoXCT), and Pressurized Isothermal Microcalorimetry possess the potential for accelerating pMDI formulation and are developed through the work embodied

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Sheth, Poonam. "Theoretical and Experimental Behavior of Suspension Pressurized Metered Dose Inhalers." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/325231.

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Pressurized metered dose inhalers (pMDIs) are widely utilized to manage diseases of the lungs, such as asthma and chronic obstructive pulmonary disease. They can be formulated such that the drug and/or nonvolatile excipients are dissolved or dispersed in the formulation, rendering a solution or suspension formulation, respectively. While the formulation process for solution pMDIs is well defined, the formulation process of pMDIs with any type of suspended entity can be lengthy and empirical. The use of suspended drug or the addition of a second drug or excipient in a suspension pMDI formulatio

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Kotian, Reshma. "Electrical Behavior of Non-Aqueous Formulations: Role of Electrostatic Interactions in Pressurized Metered Dose Inhalers (pMDIs)." Unavailable until 8/19/2013, 2008. http://hdl.handle.net/10156/2280.

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Andronicou, Anna Maria l. "Usage and perceptions of over the counter oral solid dose weight loss formulations in North West England." Thesis, Liverpool John Moores University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536141.

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Snyman, Mathys Gerhardus. "Comparative pharmacokinetics of a single and double dose of a conventional oxytetracycline formulation in sheep, to allow for therapeutic optimisation." Diss., Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-02162009-130947/.

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Lavor, Edilene Pereira. "Estudo de pr?-formula??o para dose fixa combinada dos tuberculost?ticos rifampicina, isoniazida, pirazinamida e etambutol (4 em 1)." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13458.

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Made available in DSpace on 2014-12-17T14:16:26Z (GMT). No. of bitstreams: 1 EdilenePL_DISSERT.pdf: 1151865 bytes, checksum: 7a412187753da50d4030404745c567f7 (MD5) Previous issue date: 2010-02-26<br>According to the global framework regarding new cases of tuberculosis, Brazil appears at the 18th place. Thus, the Ministry of Health has defined this disease as a priority in the governmental policies. As a consequence, studies concerning treatment and prevention have increased. Fixed-dose combination formulations (FDC) are recognized as beneficial and are recommended by WHO, but they present in

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Sogias, Ioannis Andrea. "Mucoadhesion of chitosan and derivatives : from mechanism to dosage form design : understanding of chitosan solubility parameters, interactions with mucosal membranes and BCS class II drugs in formulations, targeting enhanced permeation and increased bioavailability of poorly absorbable drugs." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499371.

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Chitosan is a natural polysaccharide produced commercially from chitin by partial deacetylation. It consists of glucosamine and Al-acetyl glucosamine units chained through glycosidic bonds. Due to the biocompatible and mucoadhesive profile it presents, it has attracted considerable attention for potential uses in pharmaceutics. However, the limited solubility of chitosan only in acidic solutions constrains some of its possible uses in biological applications. Thus, the synthesis of chitosan derivatives with broader solubility and increased functionality has been considered as a strategy to ext

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Salazar, Pablo de [Verfasser], and Peter [Akademischer Betreuer] Kremsner. "A clinical phase III comparative, randomised, clinical trial to assess the safety and efficacy of a fixed dose of oral pyronaridine-artesunate granule formulation (60 : 20) (paediatric Pyramax®) versus artemether-lumefantrine (Coartem®) crushed tablets in infants and children with acute uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon / Pablo de Salazar ; Betreuer: Peter G. Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199615153/34.

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Salazar, Pablo de Verfasser], and Peter [Akademischer Betreuer] [Kremsner. "A clinical phase III comparative, randomised, clinical trial to assess the safety and efficacy of a fixed dose of oral pyronaridine-artesunate granule formulation (60 : 20) (paediatric Pyramax®) versus artemether-lumefantrine (Coartem®) crushed tablets in infants and children with acute uncomplicated Plasmodium falciparum malaria in Lambaréné, Gabon / Pablo de Salazar ; Betreuer: Peter G. Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199615153/34.

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