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Journal articles on the topic 'Dose titration'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Nalamachu, MD, Srinivas R., Neha Parikh, Larry Dillaha, MD, and Richard Rauck, MD. "Lack of correlation between the effective dose of fentanyl sublingual spray for breakthrough cancer pain and the around-the-clock opioid dose." Journal of Opioid Management 10, no. 4 (July 1, 2014): 247. http://dx.doi.org/10.5055/jom.2014.0212.

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Objective: To examine the relationship between the dose of fentanyl sublingual spray needed to control breakthrough cancer pain (BTCP) and the dose of around-the-clock (ATC) opioid used to control background pain.Design: Analysis was based on the open-label, dose-titration phase (up to 26 days) of a randomized, double-blind, placebo-controlled trial.Patients: Opioid-tolerant cancer patients (aged ≥18 years) with chronic pain of ≤moderate severity in the 24 hours before screening while receiving stable doses of scheduled ATC opioid therapy for ≥1 week and 1 to 4 episodes of BTCP per day.Interve

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Bond, T. Christopher, Jaime Rubin, Steven X. Wang, and Alex Yang. "More Frequent Hemoglobin Measurements and More Frequent Epoetin Alfa Titrations Are Both Associated with Increased Epoetin Alfa Dose but Not More Time in Target Hemoglobin Range,." Blood 118, no. 21 (November 18, 2011): 4194. http://dx.doi.org/10.1182/blood.v118.21.4194.4194.

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Abstract Abstract 4194 For the past 20 years, management of hemoglobin (Hb) level via erythropoiesis-stimulating agents (ESAs), such as epoetin alfa (EPO) has been the norm in the care of end-stage renal disease (ESRD) patients. Recently, questions about patient safety and new economic bundling rules have brought renewed focus on appropriate Hb targets and how they relate to the use of EPO. Important issues related to Hb control are the frequency of Hb measurements, Hb value, the frequency of changes in EPO dose (titrations), and total EPO dose. Current practice aims to achieve greater control

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3

MASSEY, J. A., and P. ABRAMS. "Dose Titration in Clinical Trials." British Journal of Urology 58, no. 2-4 (April 1986): 125–28. http://dx.doi.org/10.1111/j.1464-410x.1986.tb09010.x.

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4

Papangkorn, Kongnara, Kiran Vangara, Benjamin J. Bruno, Kilyoung Kim, Nachiappan Chidambaram, Anthony DelConte, Mahesh Patel, et al. "Efficacy and Safety of TLANDO, A Novel Oral Easy to Prescribe and Use TRT Option." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A486. http://dx.doi.org/10.1210/jendso/bvab048.994.

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Abstract Most widely used testosterone replacement therapy (TRT) products can be inconvenient and cumbersome topical and invasive injectable requiring dose adjustments to attain efficacy. In a pivotal study, a recently approved oral TRT only 26% of patients did not require any dose adjustment. Typically, patients start on a sub-therapeutic dose with gradual dose increases to attain efficacy resulting in additional visit(s) to clinic and pharmacy. Physician research data (N=402) suggested it typically takes 3-6 months of titrations to reach an efficacious dose for majority of patients, a signif

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Lin, Rongbo, Jinfeng Zhu, Shuitu Feng, Sunzhi Lin, Jianqian Fu, Yongzhi Yao, Lixia Hong, et al. "Patient controlled analgesia (PCA) versus non-PCA intravenous hydromorphone titration for severe cancer pain: A randomized, controlled, multicenter, phase III trial, HMORCT09-1." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): TPS11635. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.tps11635.

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TPS11635 Background: The opioid dose for an individual with cancer pain to provide adequate relief of pain with an acceptable degree of side effects is variable. Opioid titration is a process to obtain the tailored dose. Conventional titration is administered by a clinician or nurse. PCA is that patients control cancer pain by self-administration of intravenous opioids using programmable pump. The aim of our study is to evaluate the efficacy of PCA titration versus conventional titration intravenously for severe cancer pain (10-point numerical rating scale, NRS ≥ 7). Injectable Hydromorphone w

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Norris, David C. "Dose Titration Algorithm Tuning (DTAT) should supersede the Maximum Tolerated Dose (MTD) concept in oncology dose-finding trials." F1000Research 6 (February 7, 2017): 112. http://dx.doi.org/10.12688/f1000research.10624.1.

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Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational drug. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of ‘the’ maximum tolerated dose (MTD). The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be concei

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7

Yeh, Yu-Chen, Joseph C. Cappelleri, Xiaocong L. Marston, and Ahmed Shelbaya. "Effects of dose titration on adherence and treatment duration of pregabalin among patients with neuropathic pain: A MarketScan database study." PLOS ONE 16, no. 1 (January 20, 2021): e0242467. http://dx.doi.org/10.1371/journal.pone.0242467.

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Objective To examine pregabalin dose titration and its impact on treatment adherence and duration in patients with neuropathic pain (NeP). Methods MarketScan database (2009–2014) was used to extract a cohort of incident adult pregabalin users with NeP who had at least 12 months of follow-up data. Any dose augmentation within 45 days following the first pregabalin claim was defined as dose titration. Adherence (measured by medication possession ratio/MPR) and persistence (measured as the duration of continuous treatment) were compared between the cohorts with and without dose titration. Logisti

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Santosh Kumar, Rada, and R. Venkata Sandhya. "Titration Design: An Important Key in Drug Dose Determination." Journal of Drug Delivery and Therapeutics 9, no. 4-s (August 29, 2019): 826–28. http://dx.doi.org/10.22270/jddt.v9i4-s.3374.

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Drug titration is the process of adjusting the dose of a medicine for the maximum benefits without adverse effects. To determine the optimum dose range the clinical trials are carried out and it is divided into two types of study design. The parallel type study design and titration type study design. The titration studies provide the information about the cumulative effects of the drug. Titration designs are mainly used in dose determining especially in insulin, anticonvulsants, anti-depressants, and sedatives. In the analysis of titration design, the phase I, II, III clinical trials are carri

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9

Anis, Mursalin M., and Natasha Pollak. "Treatment of Palatal Myoclonus with Botulinum Toxin Injection." Case Reports in Otolaryngology 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/231505.

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Palatal myoclonus is a rare cause of pulsatile tinnitus in patients presenting to the otolaryngology office. Rhythmic involuntary contractions of the palatal muscles produce the pulsatile tinnitus in these patients. Treatment of this benign but distressing condition with anxiolytics, anticonvulsants, and surgery has been largely unsuccessful. A few investigators have obtained promising results with botulinum toxin injection into the palatal muscles. We present a patient with palatal myoclonus who failed conservative treatment with anxiolytics. Unilateral injection of botulinum toxin into her t

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Tomita, Yoshihiko, Hirotsugu Uemura, Mototsugu Oya, Nobuo Shinohara, Tomonori Habuchi, Yosuke Fujii, Yoichi Kamei, Yoshiko Umeyama, A. H. Bair, and Brian I. Rini. "Patients with metastatic renal cell carcinoma who have benefit from axitinib dose titration: Analysis from a randomized, double-blind, axitinib dose titration phase II study." Journal of Clinical Oncology 35, no. 6_suppl (February 20, 2017): 438. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.438.

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438 Background: Axitinib is a potent, selective inhibitor of VEGF receptors. In a randomized, double-blind, phase II study in patients with metastatic renal cell carcinoma, median overall survival (OS) was 42.7 months who underwent axitinib titration versus (vs.) 30.4 months in placebo titration (hazard ratio [HR]: 0.785; 95% confidence interval: 0.485, 1.272). OS Kaplan-Meier curves for two arms appeared to cross over at approximately 24 months and thus we investigated baseline characteristics associated with OS benefit from axitinib titration. Methods: Patients received axitinib 5 mg twice d

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Chung, Ka Fai, and Susan Joyce Wong. "Stimulus dose titration for electroconvulsive therapy." Psychiatry and Clinical Neurosciences 55, no. 2 (April 2001): 105–10. http://dx.doi.org/10.1046/j.1440-1819.2001.00795.x.

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Bastiampillai, Tarun, Jessica Dalwood, Rohan Dhillon, and Prashant Tibrewal. "Why not rapid clozapine dose titration?" Asian Journal of Psychiatry 26 (April 2017): 13. http://dx.doi.org/10.1016/j.ajp.2016.12.010.

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Jensen, Rikke Beck, Ajay Thankamony, Susan M. O'Connell, Jeremy Kirk, Malcolm Donaldson, Sten-A. Ivarsson, Olle Söder, et al. "A randomised controlled trial evaluating IGF1 titration in contrast to current GH dosing strategies in children born small for gestational age: the North European Small-for-Gestational-Age Study." European Journal of Endocrinology 171, no. 4 (October 2014): 509–18. http://dx.doi.org/10.1530/eje-14-0419.

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BackgroundShort children born small for gestational age (SGA) are treated with a GH dose based on body size, but treatment may lead to high levels of IGF1. The objective was to evaluate IGF1 titration of GH dose in contrast to current dosing strategies.MethodsIn the North European Small-for-Gestational-Age Study (NESGAS), 92 short pre-pubertal children born SGA were randomised after 1 year of high-dose GH treatment (67 μg/kg per day) to three different regimens: high dose (67 μg/kg per day), low dose (35 μg/kg per day) or IGF1 titration.ResultsThe average dose during the second year of the ran

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Xu, Xu Steven, Min Yuan, and Partha Nandy. "Analysis of dose-response in flexible dose titration clinical studies." Pharmaceutical Statistics 11, no. 4 (March 11, 2012): 280–86. http://dx.doi.org/10.1002/pst.1498.

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15

Rosenman, Stephen J. "Electroconvulsive therapy stimulus titration: Not all it seems." Australian & New Zealand Journal of Psychiatry 52, no. 5 (December 5, 2017): 410–14. http://dx.doi.org/10.1177/0004867417743793.

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Objective: To examine the provenance and implications of seizure threshold titration in electroconvulsive therapy. Background: Titration of seizure threshold has become a virtual standard for electroconvulsive therapy. It is justified as individualisation and optimisation of the balance between efficacy and unwanted effects. Result: Present day threshold estimation is significantly different from the 1960 studies of Cronholm and Ottosson that are its usual justification. The present form of threshold estimation is unstable and too uncertain for valid optimisation or individualisation of dose.

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Rini, Brian I., Viktor Gruenwald, Mayer N. Fishman, Bohuslav Melichar, Takeshi Ueda, A. H. Bair, Ying Chen, et al. "Axitinib with or without dose titration for first-line metastatic renal cell carcinoma (mRCC): Unblinded results from a randomized phase II study." Journal of Clinical Oncology 31, no. 6_suppl (February 20, 2013): LBA349. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.lba349.

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LBA349 Background: Patients receiving the 5-mg twice daily (BID) axitinib starting dose exhibit variable drug exposure; prior pharmacokinetic analyses indicate higher exposure is associated with better outcomes in mRCC. Dose titration based on individual tolerability may optimize exposure and improve efficacy. Methods: Patients (N=213) with treatment-naïve mRCC received axitinib 5 mg BID for a 4-week lead-in period. Then, patients with 2 consecutive weeks of blood pressure ≤150/90 mmHg, no axitinib-related toxicities >grade 2, no dose reductions, and ≤2 antihypertensive medications were ran

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Legrand, S. B., B. Estfan, D. Walsh, M. P. Davis, and R. L. Lagman. "Parenteral opioid dose titration and ventilatory function." Journal of Clinical Oncology 22, no. 14_suppl (July 15, 2004): 8005. http://dx.doi.org/10.1200/jco.2004.22.90140.8005.

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Legrand, S. B., B. Estfan, D. Walsh, M. P. Davis, and R. L. Lagman. "Parenteral opioid dose titration and ventilatory function." Journal of Clinical Oncology 22, no. 14_suppl (July 15, 2004): 8005. http://dx.doi.org/10.1200/jco.2004.22.14_suppl.8005.

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19

Chang, Yeu-Jhy, Shan-Jin Ryu, and Tsong-Hai Lee. "Dose Titration to Reduce Dipyridamole-Related Headache." Cerebrovascular Diseases 22, no. 4 (2006): 258–62. http://dx.doi.org/10.1159/000094013.

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20

Buti, Sebastiano, and Camillo Porta. "Axitinib dose titration: what's the limiting factor?" Lancet Oncology 14, no. 12 (November 2013): 1152–54. http://dx.doi.org/10.1016/s1470-2045(13)70489-3.

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21

Kellner, Charles H., George Petrides, Kevin O'Connor, and Rafik Istafanous. "To Restimulate or Not in Dose Titration." Journal of ECT 23, no. 4 (December 2007): 293–94. http://dx.doi.org/10.1097/yct.0b013e318141f982.

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Scott, Allan I. F. "To Restimulate or Not in Dose Titration." Journal of ECT 24, no. 4 (December 2008): 294. http://dx.doi.org/10.1097/yct.0b013e31816fe9ba.

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23

Saunders, J., N. Willmott, A. Palasz, and R. J. Mapletoft. "Dose titration of Folltropin in the cow." Theriogenology 33, no. 1 (January 1990): 319. http://dx.doi.org/10.1016/0093-691x(90)90743-d.

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Laidlaw, J., P. Bentham, G. Khan, V. Staples, A. Dhariwal, B. Coope, E. Day, C. Fear, C. Marley, and J. Stemman. "A comparison of stimulus dosing methods for electroconvulsive therapy." Psychiatric Bulletin 24, no. 5 (May 2000): 184–87. http://dx.doi.org/10.1192/pb.24.5.184.

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Aims and MethodsA prospective study comparing initial electroconvulsive therapy treatment doses determined by empirical dose titration with estimates derived from two simple dose prediction methods and a fixed-dose regimen (275 mC).ResultsThirty-three patients had seizure thresholds between 25 mC and 403 mC. The dose titration method led to a mean initial treatment dose of 195 mC that was intermediate between those predicted by the age method (275 mC) and the half-age method (137 mC). Estimates were within acceptable limits in 33% of cases for the age method, 64% for the half-age method and 40

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Norris, David C. "Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD) in oncology dose-finding trials." F1000Research 6 (March 30, 2017): 112. http://dx.doi.org/10.12688/f1000research.10624.2.

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Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational therapy. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of ‘the’ maximum tolerated dose (MTD). The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be con

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Norris, David C. "Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD) in oncology dose-finding trials." F1000Research 6 (July 17, 2017): 112. http://dx.doi.org/10.12688/f1000research.10624.3.

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Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational therapy. While progress has been made toward explicitly adaptive dose-finding and quantitative modeling of dose-response relationships, most such work continues to be organized around a concept of ‘the’ maximum tolerated dose (MTD). The purpose of this paper is to demonstrate concretely how the aim of early-phase trials might be con

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Wells, DNSc, RN, Nancy, Barbara Murphy, MD, Stacey Douglas, MSN, RN, and Nancy Yelton, MSN, RN. "Establishing the safety and efficacy of an opioid titration protocol." Journal of Opioid Management 1, no. 1 (March 1, 2005): 41. http://dx.doi.org/10.5055/jom.2005.0011.

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The primary goal of this single-group study was to determine the safety of a standard opioid titration order sheet to manage pain in ambulatory cancer patients. Secondary goals were to examine opioid toxicity and efficacy of this pain protocol.Twenty-seven patients who required fixed-dose opioids and who had uncontrolled pain were enrolled. All patients had their initial opioid dose titrated by the study physician using the opioid titration order sheet. Data were obtained by the study nurse during a weekly telephone interview and used to determine if pain was controlled. After initial titratio

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Tiller, John W. G., and Nicholas Ingram. "Seizure Threshold Determination for Electroconvulsive Therapy: Stimulus dose Titration Versus Age-Based Estimations." Australian & New Zealand Journal of Psychiatry 40, no. 2 (February 2006): 188–92. http://dx.doi.org/10.1080/j.1440-1614.2006.01773.x.

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Objective: This study compared electroconvulsive therapy (ECT) seizure threshold determined by stimulus dose titration with age-based estimations. Method: Patients with major depressive disorder had their initial seizure thresholds determined by stimulus dose titration and the results compared with age-based estimations. There are no significant differences in thresholds determined by these methods. Results: Two hundred and three psychiatric patients (149 females, 54 males) had their seizure thresholds determined by stimulus dose titration. There was a significant positive correlation between

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Wilhelm, Amanda, Karen E. Anderson, Hubert H. Fernandez, Hadas Barkay, Nayla Chaijale, Alexander F. Send, Juha-Matti Savola, and Mark Forrest Gordon. "Comparison of Safety and Tolerability of Deutetrabenazine During Titration and Maintenance in Patients with Tardive Dyskinesia." CNS Spectrums 26, no. 2 (April 2021): 164. http://dx.doi.org/10.1017/s1092852920002643.

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AbstractBackgroundDeutetrabenazine is approved to treat tardive dyskinesia (TD) in adults and is titrated weekly by 6 mg/day, from 12 to 48 mg/day, based on dyskinesia control and tolerability. This analysis compared the safety of deutetrabenazine during titration versus maintenance.MethodsSafety was assessed during titration versus maintenance using integrated data from two 12-week placebo-controlled studies (ARM-TD and AIM-TD) and the open-label extension study. Rates were compared for overall and serious adverse events (AEs), AEs leading to discontinuation, treatment-related AEs, common AEs

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Suntharalingam, J., D. Hodgkins, F. H. Cafferty, R. J. Hughes, and J. Pepke-Zaba. "Does rapid dose titration affect the hepatic safety profile of Bosentan?" Vascular Pharmacology 44, no. 6 (June 2006): 508–12. http://dx.doi.org/10.1016/j.vph.2006.03.004.

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Sumethkul, Kittiwan, Tasanee Kitumnuaypong, Sungchai Angthararak, and Warangkana Pichaiwong. "Low-dose cyclosporine for active lupus nephritis: a dose titration approach." Clinical Rheumatology 38, no. 8 (April 1, 2019): 2151–59. http://dx.doi.org/10.1007/s10067-019-04469-6.

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Wroe, SJ. "Effects of Dose Titration on Tolerability and Efficacy of Interferon Beta-1b in People with Multiple Sclerosis." Journal of International Medical Research 33, no. 3 (May 2005): 309–18. http://dx.doi.org/10.1177/147323000503300306.

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Multiple sclerosis (MS) treatment with interferon beta is associated with well-known, easily managed adverse events, including influenza-like symptoms and injection-site reactions that decline over time. Initial dose titration has been shown to be one way of limiting these adverse events. Hence, a placebo-controlled, multicentre study of 98 patients was set up to explore whether a slower, four-stage, 4-week titration to a final dose of 250 μg subcutaneous interferon beta-1b might improve tolerability over a more rapid two-stage, 2-week titration in patients with relapsing-remitting MS. Frequen

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Alva Venur, Vyshak, Laura S. Wood, Paul Elson, Allison Martin, Jennifer Beach, Jorge A. Garcia, and Brian I. Rini. "An alternative titration schedule of axitinib in metastatic renal cell carcinoma." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 444. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.444.

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444 Background: Titration of axitinib for metastatic renal cell carcinoma (mRCC) is currently based on tolerance with escalation from 10 mg/day to 14 mg/day and then to 20 mg/day. However, not all patients who can be titrated upward require a higher dose for response, nor do all patients tolerate the increased dose levels. An alternative titrating strategy was employed based on radiographic response, tolerance, and using intermediate dosing levels. Methods: In this retrospective analysis of mRCC, axitinib was initiated at 10 mg/day (5 mg BID). Response was assessed with CT scans at 6 weeks aft

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Ioachimescu, Adriana Gabriela, Richard Joseph Auchus, Wenyu Huang, Joanna L. Spencer-Segal, Kevin Choong Ji Yuen, Kelley C. Dacus, William Henry Ludlam, et al. "LBMON177 Dosing And Titration Of Osilodrostat In A Real-world Cohort Of US Patients With Endogenous Cushing's Disease: Analysis Of The ILLUSTRATE Study." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A473—A474. http://dx.doi.org/10.1210/jendso/bvac150.983.

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Abstract Background Osilodrostat, a potent oral inhibitor of 11β-hydroxylase, demonstrated efficacy in normalizing urinary free cortisol (UFC) in Cushing's disease (CD) patients; however, information describing its use in clinical practice is limited. We present osilodrostat dosing and titration information from a real-world cohort of endogenous Cushing's syndrome (CS) patients, focused on CD. Methods ILLUSTRATE, a retrospective chart review study analyzed confirmed endogenous CS patients who initiated osilodrostat treatment May 1, 2020 - October 29, 2021. Forty-two adult patients with endogen

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Shastry, R., P. Adhikari, A. Kamath, M. Chowta, S. Ullal, and MRSM Pai. "Do geriatrics require dose titration for antidiabetic agents?" Journal of Postgraduate Medicine 59, no. 4 (2013): 271. http://dx.doi.org/10.4103/0022-3859.123153.

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Marushko, Yu V., Yu I. Todyka, and Ye Yu Marushko. "Clinical Effectiveness and Dose Titration in Pediatric Practice." CHILD`S HEALTH, no. 1.69 (March 10, 2016): 41. http://dx.doi.org/10.22141/2224-0551.1.69.2016.73704.

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Albsoul-Younes, Abla M., Hazem A. Salem, Saleh F. Ajlouni, and Saafan A. Al-Safi. "Topiramate slow dose titration: Improved efficacy and tolerability." Pediatric Neurology 31, no. 5 (November 2004): 349–52. http://dx.doi.org/10.1016/j.pediatrneurol.2004.04.012.

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Harris, A. G., T. M. O'Dorisio, E. A. Woltering, L. B. Anthony, F. R. Burton, R. B. Geller, J. H. Grendell, B. Levin, and J. S. Redfern. "Consensus statement: Octreotide dose titration in secretory diarrhea." Digestive Diseases and Sciences 40, no. 7 (July 1995): 1464–73. http://dx.doi.org/10.1007/bf02285194.

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Vikre-Jørgensen, Jennifer, Lone Agertoft, and Søren Pedersen. "Dose titration of nebulized budesonide in young children." Pediatric Pulmonology 23, no. 4 (April 1997): 270–77. http://dx.doi.org/10.1002/(sici)1099-0496(199704)23:4<270::aid-ppul4>3.0.co;2-q.

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Finkelman, Brian S., Benjamin French, Luanne Bershaw, Colleen M. Brensinger, Michael B. Streiff, Andrew E. Epstein, and Stephen E. Kimmel. "Predicting prolonged dose titration in patients starting warfarin." Pharmacoepidemiology and Drug Safety 25, no. 11 (July 26, 2016): 1228–35. http://dx.doi.org/10.1002/pds.4069.

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Banefelt, Jonas, Maria Lindh, Maria K. Svensson, Björn Eliasson, and Ming-Hui Tai. "Statin dose titration patterns and subsequent major cardiovascular events in very high-risk patients: estimates from Swedish population-based registry data." European Heart Journal - Quality of Care and Clinical Outcomes 6, no. 4 (April 1, 2020): 323–31. http://dx.doi.org/10.1093/ehjqcco/qcaa023.

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Abstract Aims Clinical studies have demonstrated the efficacy of intensive statin therapy in lowering low-density lipoprotein cholesterol and cardiovascular (CV) events. Our objective was to examine statin titration patterns and the association between titration patterns and subsequent CV events in very high-risk patients. Methods and results Using Swedish national population-based registry data, we identified 192 435 patients with very high risk of atherosclerotic CV disease initiated on moderate-intensity statin therapy between 2006 and 2013. Outcomes of interest were titration to high-inten

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Khaw, Chelsea, and Tami Argo. "Prazosin initiation and dose titration in a patient with posttraumatic stress disorder on concurrent carvedilol." Mental Health Clinician 9, no. 5 (September 1, 2019): 326–30. http://dx.doi.org/10.9740/mhc.2019.09.326.

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Abstract One mechanism involved in the pathophysiology of posttraumatic stress disorder (PTSD) is increased noradrenergic stimulation. Prazosin, a commonly utilized treatment for PTSD nightmares, works to block noradrenergic stimulation of the alpha-1 adrenoreceptor. Dual antagonism of this receptor would be expected to increase risk of adverse effects. Carvedilol has both alpha-1 adrenergic and nonselective beta-adrenoreceptor antagonist activity. To our knowledge, there is no clinical guidance on use of prazosin in patients concomitantly prescribed carvedilol for hypertension. This case desc

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Thorpy, Michael, Danielle Hyman, Gregory Parks, Abby Chen, Catherine Foley, Diane Ito, and Haramandeep Singh. "482 Solriamfetol Titration & AdministRaTion (START): dosing and titration strategies in patients with narcolepsy starting solriamfetol." Sleep 44, Supplement_2 (May 1, 2021): A190. http://dx.doi.org/10.1093/sleep/zsab072.481.

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Abstract Introduction Solriamfetol (Sunosi®), a dopamine/norepinephrine reuptake inhibitor, is approved (US and EU) to treat excessive daytime sleepiness (EDS) in adults with narcolepsy (75–150 mg/day) or obstructive sleep apnea (OSA) (37.5–150 mg/day). Previous research examined the use of solriamfetol in clinical trial settings but research in real-world settings was not previously conducted. This study characterized real-world dosing and titration with solriamfetol. Methods This virtual, descriptive study included a quantitative retrospective patient chart review among US-based physicians p

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Castellana, Marco, Filippo Procino, Rodolfo Sardone, Pierpaolo Trimboli, and Gianluigi Giannelli. "Efficacy and safety of patient-led versus physician-led titration of basal insulin in patients with uncontrolled type 2 diabetes: a meta-analysis of randomized controlled trials." BMJ Open Diabetes Research & Care 8, no. 1 (July 2020): e001477. http://dx.doi.org/10.1136/bmjdrc-2020-001477.

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IntroductionInsulin is the most effective antihyperglycemic treatment and basal insulin is the preferred initial formulation in patients with type 2 diabetes. However, its effects are dose-dependent, so adequate titration is necessary to reach targets. We performed a meta-analysis to compare the efficacy and safety of patient-led versus physician-led titration of basal insulin in patients with uncontrolled type 2 diabetes.Research design and methodsFour databases were searched from database inception through March 2020. Randomized controlled studies with at least 12 weeks of follow-up of patie

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Wertheim, M. S., H. Jhangiani, G. Niebler, and V. Charu. "Finding an effective dose of fentanyl effervescent buccal tablets: Combined results of open-label titration." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 18521. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.18521.

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18521 Background: Standard recommendations for short-acting oral opioid doses to manage breakthrough pain (BTP) assume some relation with the stable opioid dose used to treat persistent pain. Fentanyl effervescent buccal tablets (FEBT) are designed to enhance the efficiency of fentanyl absorption through the buccal mucosa. They may provide rapid-onset analgesia. This pooled analysis of data from 3 studies examined the relationship between effective FEBT dose and around-the-clock (ATC) dose in patients who completed open-label titration to an effective FEBT dose. Methods: Patients were 18–80 ye

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Kovačević, Dragan, and Sanja Kovačević. "Significance of beta-blocker dose titration in heart failure." Galenika Medical Journal 1, no. 4 (2022): 53–58. http://dx.doi.org/10.5937/galmed2204055k.

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Heart failure is a clinical syndrome, characterized by the inability of the heart to pump an adequate amount of blood according to the needs of the organs and tissues, at rest and during exertion, despite normal blood flow to the heart. Treatment includes hygienic and dietary measures, pharmacological treatment, installation of an appropriate device, surgical treatment and heart transplantation. Indispensable groups of drugs that reduce mortality in the treatment of this disease are beta-blockers, angiotensin-converting enzyme inhibitors (ACE inhibitors)/angiotensin receptor neprilysin inhibit

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Nauta, J. F., B. T. Santema, M. H. L. van der Wal, A. Koops, J. Warink-Riemersma, K. van Dijk, F. Inkelaar, et al. "Improvement in left ventricular ejection fraction after pharmacological up-titration in new-onset heart failure with reduced ejection fraction." Netherlands Heart Journal 29, no. 7-8 (June 14, 2021): 383–93. http://dx.doi.org/10.1007/s12471-021-01591-6.

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Abstract Objective Recent studies have reported suboptimal up-titration of heart failure (HF) therapies in patients with heart failure and a reduced ejection fraction (HFrEF). Here, we report on the achieved doses after nurse-led up-titration, reasons for not achieving the target dose, subsequent changes in left ventricular ejection fraction (LVEF), and mortality. Methods From 2012 to 2018, 378 HFrEF patients with a recent (< 3 months) diagnosis of HF were referred to a specialised HF-nurse led clinic for protocolised up-titration of guideline-directed medical therapy (GDMT). The achieved d

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Salonen, K., M. Leisola, and T. Eerikäinen. "Developing a multipoint titration method with a variable dose implementation for anaerobic digestion monitoring." Water Science and Technology 59, no. 12 (June 1, 2009): 2395–403. http://dx.doi.org/10.2166/wst.2009.275.

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Determination of metabolites from an anaerobic digester with an acid base titration is considered as superior method for many reasons. This paper describes a practical at line compatible multipoint titration method. The titration procedure was improved by speed and data quality. A simple and novel control algorithm for estimating a variable titrant dose was derived for this purpose. This non-linear PI-controller like algorithm does not require any preliminary information from sample. Performance of this controller is superior compared to traditional linear PI-controllers. In addition, simplifi

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Nerurkar, N. K., and T. P. Banu. "Spasmodic dysphonia: a seven-year audit of dose titration and demographics in the Indian population." Journal of Laryngology & Otology 128, no. 7 (July 2014): 649–53. http://dx.doi.org/10.1017/s002221511400142x.

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AbstractObjectives:This study aimed to evaluate the demographics of spasmodic dysphonia in the Indian population and to analyse the optimum dose titration of botulinum toxin type A in this group. A comparative analysis with international studies was also performed.Method:The study involved a retrospective analysis and audit of botulinum toxin type A dose titration in spasmodic dysphonia patients who visited our voice clinic between January 2005 and January 2012.Results:The average total therapeutic dose required for patients with adductor spasmodic dysphonia was 4.2 U per patient per vocal fol

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Getchell, R. G., G. A. Wooster, C. A. Sutton, J. W. Casey, and P. R. Bowser. "Dose Titration of Walleye Dermal Sarcoma (WDS) Tumor Filtrate." Journal of Aquatic Animal Health 14, no. 4 (December 2002): 247–53. http://dx.doi.org/10.1577/1548-8667(2002)014<0247:dtowds>2.0.co;2.

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