Academic literature on the topic 'Dosos over 80 years'
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Journal articles on the topic "Dosos over 80 years"
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Platonov, D. Yu, and S. N. Bel'diev. "Arterial hypertension management in patients over 80 years old: comment on the position agreement of the Russian experts." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 24, no. 6 (January 26, 2019): 646–53. http://dx.doi.org/10.18705/1607-419x-2018-24-6-646-653.
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The article discusses four statements of the position agreement of the Russian experts on the treatment of arterial hypertension in patients over 80 years old, as well as in patients with senile asthenia. These statements consider recommendations on the threshold and target blood pressure levels, on the initial antihypertensive therapy (monotherapy or combination therapy), the initial doses of the drugs (low or high) in patients over 80 years old with or without senile asthenia. The authors believe that these statements require some correction as they do not fully correspond to the results of the HYVET trial. The level of evidence and recommendation class stated in the position agreement are disputable and give rise to doubt. The authors compare the position agreement by the Russian experts and European guidelines 2013 and present the evidence of the large randomized clinical trials and meta-analyses.
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Lemez, Petr, Jirina Galikova, Kyra Michalova, Alan MacWhannell, Zuzana Zemanova, and Jan Stejskal. "Standard Dose Chemotherapy 3+7 Induces Complete Remission in Patients Over 80 Years Old with Single-Lineage Acute Myeloid Leukemias and Normal Karyotype." Blood 112, no. 11 (November 16, 2008): 4006. http://dx.doi.org/10.1182/blood.v112.11.4006.4006.
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Abstract Survival of elderly patients with de novo acute myeloid leukemia (AML) is poor. A single published study on patients with AML aged 80 years and above (DeLima et al., Br. J. Haematol.1996; 93: 89) concluded that chemotherapy was not indicated since median overall survival (OS) of 29 treated patients was 1 month, 9 patients reached complete remission (CR) of 3 months median duration, and only two survived over 1 year: for 15.5 and >18 months. The aim of our study was to identify the characteristics of elderly AML patients who may reach CR by standard chemotherapy. We analyzed 9 consecutive patients with de novo AML aged 80–90 (median 83) years treated by us in 1992–2007. All bone marrow films were hypercelullar with 48–92 (median 80) % leukemic cells, classified as FAB types: 2 M2, 6 M4, and 1 M5. Six patients, all with hypertension and five with ischaemic heart disease (IHD), received chemotherapy, while 3 patients (82–87 years old) opted for supportive or palliative therapy and survived 1–4 months. Cytosine arabinoside (Ara-C) 100 mg/sqm/12 h in 3-h infusion for 7 days and 3 doses of daunorubicin (DNR) 45 mg/sqm/d i.v. (D+A, 1 case) or mitozantrone (MTZ) 10 mg/sqm/d i.v. (M+A, 3 cases) was given to 4 patients. The remaining two patients received D+A with thioguanine (TG) 100 mg/sqm/12 h p.o. for 7 days (TAD). Their WHO performance status (PS) was 4x PS3, 1x PS2, 1x PS1, and median WBC 58 (17.9–97.8) × 10^9/L. Three patients with AML M4 and normal karyotype reached CR. Maintenance therapy consisted of 4-day courses administered in intervals of 5–12 (median 8) weeks according to the patient’s clinical status and tolerance until relapse. Courses containing Ara-C 60 mg/sqm/12h s.c. with TG 70 mg/sqm/12h p.o. were repeated 3x. The fourth course was 1+4 containing a single dose DNR or MTZ as described and Ara-C. The outcomes: An 85 year-old female with IHD and LVEF 25 % reached CR with TAD. She was on maintenance in CR for 17 months when severe heart arrhythmia developed. She refused a pacemaker implantation and died 3 days later. Her OS was 18.6 months. An 80 year-old male reached CR with M+A and was on maintenance therapy when relapsed after 19.7 months. He refused further chemotherapy and his OS was 28 months. An 80 year-old female (PS1, Flt3-ITD neg.) reached CR after D+A 3+7 and got one cycle D+A 2+5 without further maintenance. Her CR lasted 10.1 months. She was further treated with 2 cycles of low-dose Ara-C and her OS was 16.5 months. Three other patients, two with normal karyotype, did not reach CR after chemotherapy. A 90 year-old male with AML M4 died of mycotic pneumonia on the 24th day of TAD induction. An 83 year-old male with AML M5, PS2, experienced nonQ myocardial infarction after M+A induction and did not reach CR. He was further treated with hydroxyurea with OS of 2.7 months. An 80 year-old female with AML M2, complex karyotype, renal insufficiency and sepsis died after 7th hemodialysis in septic shock on 10th day of M+A induction. All three patients who reached CR did not exhibit dysplasia in erythroblastic or megakaryocytic lineage showing that only granulocyte-macrophage lineage was involved in the leukemic clone (single–lineage AMLs). In contrast, all 3 patients who did not reach CR exhibited megakaryocytic dysplasia in a half or more of megakaryocytes and two had erythroblastic dysplasia in more than 26% erythroblasts. They represent a different biological category of AMLs with multi-lineage involvement. In summary, we defined a biological category of single-lineage AML patients over 80 years of age who may benefit from standard dose chemotherapy in spite of their poor performance status.
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Zhdan, Viacheslav, Yevdokiia Kitura, Maryna Babanina, Oksana Kitura, and Maksym Tkachenko. "Elderly Patient with Hypertension in General Practice: Clinical Features and Antihypertensive Therapy." Family Medicine, no. 1 (March 31, 2021): 61–66. http://dx.doi.org/10.30841/2307-5112.1.2021.231938.
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The prevalence of arterial hypertension (AH) increases with age: among people over 60 years old this index is more than 2 times higher in the general population, 2/3 of people over 65 years old suffer from hypertension. Among patients 65–89 years old with hypertension, 2/3 patients have isolated systolic hypertension (ISAG). Features of hypertension in the elderly patients are: lability of blood pressure (BP), increasing frequency of pseudohypertension, high frequency of «white coat hypertension», decreased sensitivity of pressor factors for antihypertensive drugs, high frequency of resistant to treatment of hypertension. The new recommendations of the European Society of Cardiology for the diagnosis and treatment of hypertension emphasize 2 groups of elderly patients: 65–79 years old and ≥80 years old, which described the epidemiological features, the prevalence of risk factors for cardiovascular events, blood pressure levels for antihypertensive therapy and target blood pressure, and the recommended principles of drug therapy that are different from young and middle-aged patients. For most patients, fixed combinations are indicated as starting AGT, but monotherapy is recommended for the treatment of hypertension in very elderly patients (over 80 years old) and elderly patients over 65 years old with senile asthenia. The decreasing of blood pressure should be gradual, taking into consideration the increased risk of orthostatic reactions at this age. European and American experts recommend os first-line drugs low doses of thiazide diuretics and calcium channel antagonists (mainly dihydropyridine), which are especially indicated in isolated systolic arterial hypertension to effectively reduce the frequency of cardiovascular complications in the treatment of elderly patients with hypertension.
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Varga, Cindy, and Sarit E. Assouline. "Diffuse Large B-Cell Lymphoma in the Very Elderly, a Study of Outcome in Patients Aged 80 and Older." Blood 114, no. 22 (November 20, 2009): 1942. http://dx.doi.org/10.1182/blood.v114.22.1942.1942.
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Abstract Abstract 1942 Poster Board I-965 Introduction: The trial showing that the addition of rituximab to the CHOP regimen increases complete response (CR) rate and overall survival (OS) in elderly patients (pts) with diffuse large B-cell lymphoma (DLBCL) did not include pts over the age of 80 (Coiffier, 2002, NEJM). There is very limited data on octogenarians with DLBCL. These pts are often treated with reduced-dose therapeutic regimens, which may lead to a poorer OS (Meyer, 1995, J Clin Oncol). We were interested in examining the proportion of pts with DLBCL aged 80 and over in our institution; to characterize the determinants of their OS; to assess how many received standard therapy; and, to define which characteristics lead physicians to withhold therapy. Patients and method: A retrospective chart analysis was conducted of clinical and pathological data on all new cases of DLBCL from 2004 to 2008. Clinical data collected included International Prognostic Index (IPI), LDH, therapy received, and survival. Pathologic data included presence or absence of bcl-6 and/or bcl-2 expression, and proliferative fraction as determined by the level of Ki-67. This study received IRB approval. A Kaplan-Meier survival analysis was performed, Fisher's exact test was used to estimate p value for proportions, and confidence intervals were estimated for means. Results: We identified 54 new cases of DLBCL with a median age of 69.5 years. Fifteen pts (27.8%) were age 80 or older. Male to female ratio was 1:1.5. The average IPI was greater in pts above 80 than in pts below 80 years of age, 3.0 [95% confidence interval (CI), 2.17-3.83] vs. 1.9 [95% CI, 1.51-2.29 ], respectively. The LDH was high in 57.9% (22/38) of pts in the younger group vs. 69.2% (9/13) of pts in the older group (p=0.52). The presence of bcl-6 in the younger group versus the older group was 88.6% (31/35) and 84.6% (11/13), respectively (p = 0.65). The expression of bcl-2 in the younger group versus the older group was 55.9% (19/34) and 66.7% (8/12), respectively (p=0.73). The proportion of younger pts vs. older pts with high Ki67 (>80%) was 45.7% vs. 53.8%, respectively (p= 0.75). Thirty six pts under age 80 received RCHOP compared to 7 pts 80 years and over (97.3% vs. 50%) (p=0.0006). There did not seem to be a correlation between IPI or co-morbidity and whether pts received treatment. However, therapy tended to be offered to outpatients but withheld from patients hospitalized at time of diagnosis. Chemotherapy had to be reduced or terminated due to poor tolerance in 1 patient in the younger cohort vs. 2 pts in the older cohort. Amongst the older group who did not receive RCHOP, 6 pts (85.7%) did not receive any chemotherapy, while 1 patient received 5 cycles of RCEPP. Kaplan Meier analysis for overall survival of pts under age 80 compared to over age 80 is shown below (HR = 7.0, 95% CI [2.0 – 24.2]), (p = 0.002). All pts above age 80 who did not receive any chemotherapy died vs. 25.0% (1/4) who received full dose RCHOP, vs. 66.7% (2/3) who received reduced RCHOP. The CR rate was 88.6% (31/35) for those aged under 80 vs. 75% (6/8) for those above age 80 (p=0.31), while the relapse rate was 11.4% (4/35) vs. 25% (2/8), respectively (p = 0.31). Conclusions: Though limited, these data reveal interesting findings about pts aged over 80 with DLBCL. With our aging population, more physicians will be faced with the question of how to treat the very elderly with this diagnosis. These pts had a poorer overall survival which, in large part, can be attributed to the fact that therapy was never administered. Age above 80 and hospitalization seemed to be the only clear reasons for withholding therapy. Elderly pts tended to have higher IPIs, but did not seem to have histologically more aggressive tumours. Interestingly, the pts over the age of 80 who died did tend to have more frequent expression of bcl-2. In contrast, all elderly pts who survived were bcl-6 positive. When standard therapy is given to pts over the age of 80, their response rates do not differ from those in younger pts. Further research into pts above 80 years of age with DLBCL is needed to confirm our findings. Nonetheless, our results raise questions about how we approach treatment of DLBCL in the very elderly and suggest that age alone should not prevent standard doses of therapy from being administered. 1. Kaplan-Meier survival curves for the two age groups: Disclosures: No relevant conflicts of interest to declare.
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Sood, Gaurav, Rajesh Kaushal, Anjali Chauhan, and Shaweta Gupta. "Indigenous plant-growth-promoting rhizobacteria and chemical fertilisers: impact on wheat (Triticum aestivum) productivity and soil properties in North Western Himalayan region." Crop and Pasture Science 69, no. 5 (2018): 460. http://dx.doi.org/10.1071/cp18016.
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High levels of crop productivity cannot be sustained by chemical fertiliser application alone. In order to mitigate this, a 2-year study was conducted to test the effects of combined application of indigenous plant-growth-promoting rhizobacteria (PGPR) and chemical fertilisers on productivity of wheat and soil properties. Ten morphologically distinct indigenous PGPR isolates from wheat roots and rhizosphere were evaluated at Solan, Himachal Pradesh, India, during 2013–14. Three PGPR isolates (B2, SIR1 and BIS2) with maximum PGP traits were screened at different doses of nitrogen (N) and phosphorus (P) (80%, 60% and 40% of recommended fertiliser dose, RFD) under net-house conditions. Two isolates, B2 (Serratia sp.) and SIR1 (Bacillus subtilis), along with the optimum NP dose (i.e. 80% RFD) were selected for field experimentation, which was performed over two consecutive years, 2014–16. Combined application of 80% RDF of NP with PGPR (B2) significantly increased wheat yield by 9.4%, number of tillers per plant by 28.03%, grain number per spike by 19.61%, 1000-grain weight by 10.5%, and biomass by 9.2% relative to the uninoculated control with 100% RFD. Soil properties in the terms of available N, P and potassium, microbial biomass carbon, soil enzyme activities and population of phosphate-solubilising bacteria in the wheat crop were significantly increased by the combined application of bacterial inoculants with 80% RFD of NP in both years over the uninoculated control. Therefore, the results revealed the potential of indigenous PGPR isolates to supplement ~20% of NP fertilisers without hampering the soil fertility and productivity of wheat.
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Vorobyeva, N. M., and O. N. Kacheva. "Possibilities of Using Rivaroxaban in Elderly Patients with Atrial Fibrillation: Data from Randomized Studies and Real Clinical Practice." Rational Pharmacotherapy in Cardiology 14, no. 4 (September 4, 2018): 575–82. http://dx.doi.org/10.20996/1819-6446-2018-14-4-575-582.
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The possibility of rivaroxaban using in elderly patients with non-valvular atrial fibrillation is discussed in the review. The results of ROCKET-AF randomized trial, including subgroup analysis in patients older than 75 years, are presented. The problem of unreasonable prescription of low doses of anticoagulants in real clinical practice and questions of adherence of patients to anticoagulant therapy are discussed. The results of two recent studies of actual clinical practice performed in patients over the age of 80 and 85 years, respectively, are presented as well as favorable profile of the efficacy and safety of rivaroxaban in these age groups. Rivaroxaban reduced the risk of stroke/systemic embolism by 38% and ischemic stroke by 41% with a comparable risk of major bleeding in patients older than 80 years. In another study, in patients older than 85 years in the rivaroxaban group, a 11% reduction in the risk of death from all causes, a reduction in the risk of major bleeding by 10% and an acute coronary syndrome by 14%, with similar risk of stroke/systemic embolism, clinically significant minor bleeding and a combined endpoint (stroke/systemic embolism, large bleeding, death from all causes) have been found.
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Biswas, GC. "Comparative Effectiveness Of Neem Extracts And Synthetic Organic Insecticide Against Mustard Aphid." Bangladesh Journal of Agricultural Research 38, no. 2 (July 28, 2013): 181–87. http://dx.doi.org/10.3329/bjar.v38i2.15881.
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Effectiveness of different doses of neem extracts and a synthetic organic insecticide against mustard aphid was studied in the experimental farm of the Oilseed Research Centre, Bangladesh Agricultural Research Institute (BARI), Joydebpur, Gazipur, during two consecutive years 2010-2011 and 2011-2012 for the control of mustard aphid. Eight treatments were evaluated against mustard aphid under field condition. The maximum aphid population was (180 per plant) observed at the pod formation stage of mustard crop. Among the treatments, Malataf (Malathion 57EC) @ 2ml/l significantly reduced the highest aphid population (93.75%) over pretreatment which produced the highest seed yield (1440 kg/ha) of mustard. The neem leaf extracts reduced 63.16-72.55% aphid population in mustard while neem seed extract reduced 73-81% aphid population over pretreated plants in both the years. Among the different doses of neem extracts, the highest aphid population reduction over pretreatment (81%) was recorded from 50g neem seed per litre of water treated plots with high MBCR (3.88) followed by 75g neem seed/l treated plots having reduction of 80% and MBCR 3.78. Bangladesh J. Agril. Res. 38(2): 181-187, June 2013 DOI: http://dx.doi.org/10.3329/bjar.v38i2.15881
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Aoki, Kazunari, June Takeda, Yuki Hunayama, Nobuhiko Yamauchi, Aiko Kato, Yuichiro Ono, Hiroshi Arima, et al. "Prognostic Factors of Elderly Diffuse Large B-Cell Lymphoma Treated with R-CHOP: Performance Status and Age Over Eighty, but Neither Lactate Dehydrogenase Level, Stage, Nor Relative Dose Intensity Delivered, Associated with Clinical Outcome." Blood 118, no. 21 (November 18, 2011): 1610. http://dx.doi.org/10.1182/blood.v118.21.1610.1610.
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Abstract Abstract 1610 Introduction: As for the prognostic factors of elderly patients with diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP, limited reports have been available. Although the maintenance of relative dose intensity (RDI) has been considered to improve the outcome, recent reports show that dose-reduced R-CHOP also has successful results on elderly DLBCL (Lancet Oncology. 2011; 12: 460). As rigid adherence to R-CHOP protocol is difficult in the treatment of elderly DLBCL, we investigated the relationship between RDI delivered and clinical outcomes in elderly patients with DLBCL. Method: We retrospectively analyzed a total of 109 consecutive DLBCL patients over 70 years who were diagnosed and received R-CHOP in our institution between January 2004 and January 2011. Among them, 56 % were male, and 38 % were over 80 years. 49 % of patients had an Ann Arbor stage III or IV, and ECOG performance status (PS) were >= 2 in 37 %. Lactate dehydrogenase (LDH) levels were higher than normal in 60 %. Age-adjusted IPI was 2–3 in 45 %. Charlson comorbidity index (CCI) was >= 2 in 23 %. Most patients with localized disease received 3 cycles of R-CHOP (delivered with 21-day interval) followed by radiation, and patients with advanced disease received 6 or 8 cycles of R-CHOP. In the first cycles of R-CHOP therapy, patients aged 70–79 years received 70 % dose of cyclophosphamide, adriamycin and vincristine. Patients over 80 years received 50 % dose of them. Predonisolone was also reduced to 40–60 mg on day 1–5 according to patients' condition. Thereafter, the doses were individually adjusted according to attending physicians' judgment. 78 % of the patients experienced grade 3–4 neutropenia and 21 % grade 3 febrile neutropenia. Two patients died of neutropenia and infection. 65 % of patients received prophylactic G-SCF. By using clinical records of these patients, we estimated the prognostic factors using the Cox regression model. Estimates of prognostic factors were expressed as hazard ratios (HR) and 95 % confidence interval (CI) based on the Cox regression. We did two-sided statistical tests, with a 5 % level of significance. This study was approved by our institutional review board. Result: After median follow up for living patients of 25.5 months, 41 deaths has occurred (including 22 due to lymphoma), and 2-year overall survival (OS) and progression-free survival (PFS) were 71.3 % [95 % CI 60.8 %–79.5 %] and 53.5 % [95 % CI 42.7 –63.1 %], respectively. Univariate and multivariate analysis revealed that LDH and staging at diagnosis were not associated with prognosis. PS >= 2 (HR 2.94, 95 % CI 1.48–5.84, P=0.002) and age >= 80 years (HR 2.05, 95 % CI 1.04–4.04, P=0.039) retained independent adverse prognostic values for 2-year OS in multivariate analysis. Dividing entire population into 3 groups using these 2 prognostic factors, 2-year OS were 82.7 % (70 <= age < 80 and PS < 2), 67.3 % (70 <= age < 80 and PS>=2 or age>=80 and PS < 2), and 52.5 % (age >= 80 and PS >= 2), respectively (log-rank, P=0.0004). Among the all 109 patients, 91 patients received >=3 cycles of R-CHOP and RDI could be calculated. RDI was strongly associated with age (R-squared 0.42, RDI (%) = 201-1.90x age (years)). When high age-adjusted RDI group (H-aaRDI) was defined as the group of patients who satisfied □eRDI > 201 - 1.90x age', and low age-adjusted RDI group (L-aaRDI) as □eRDI< 201 - 1.90x age', 2-year OS were equivalent between H-aaRDI and L-aaRDI groups (79.8 % vs 78.7 %, log-rank, P=0.36). When multivariate analysis was performed against those 91 patients, 2-year OS was also independently associated with PS >=2 (HR 3.12, 95 % CI 1.35–7.20, P=0.008) and age >=80 (HR 2.41, 95 % CI 1.04–5.59, P=0.041). Lower age-adjusted RDI did not have prognostic value (HR 1.28, 95 % CI 0.55 – 2.94, P=0.57). Conclusion: Our retrospective analysis confirmed the efficacy of reduced-dose R-CHOP against elderly DLBCL, as was reported previously. Their prognosis was not associated with LDH level, staging, nor RDI delivered, but with ECOG PS and age over 80. Our findings indicated that strict adherence to keep RDI may not be necessary in the treatment of elderly DLBCL. The simple method to define optimal dose of R-CHOP for elderly should be explored. Disclosures: No relevant conflicts of interest to declare.
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Lauseker, Michael, Roman Gerlach, Martin Tauscher, and Joerg Hasford. "Female and Elderly Chronic Myeloid Leukemia Patients Often Do Not Receive an Adequate TKI Treatment." Blood 128, no. 22 (December 2, 2016): 3101. http://dx.doi.org/10.1182/blood.v128.22.3101.3101.
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Abstract Introduction For one and a half decade, tyrosine kinase inhibitors (TKI) have been the standard treatment for Philadelphia chromosome-positive chronic myeloid leukemia (CML). Recent studies have shown that elderly patients above 65 years benefit from a TKI treatment too. Since there were sporadic reports that elderly CML-patients receive less often TKI the aim of our study was to determine if the prescribing of TKI for CML in Germany follows the current recommendations, especially in the elderly. This was done by analyzing population-based claims data from the Bavarian Association of Statutory Health Insurance Physicians (Kassenärztliche Vereinigung Bayerns). Methods Data on ICD-10 codes as well as prescribed medication were available for about 10.5 million patients in the statutory health insurance system in Bavaria for the years 2008 to 2013. To avoid misclassification, only patients with at least two recorded diagnoses of CML over time were counted. All analyses on daily doses of TKI in this work are based on the daily doses recommended by the EMA, i.e. 400 mg/d for imatinib, 100 mg/d for dasatinib, 300 mg twice/d for nilotinib, 500 mg/d for bosutinib and 45 mg/d for ponatinib. Analyses were performed with R 3.1.0 and SPSS 22. Results 1880 different CML patients were identified between 2008 and 2013. During the six years analysed, 1,431,882 daily doses of TKI were administered. The majority of TKI doses were imatinib with 1,204,025 daily doses (84%), followed by nilotinib with 145,291 daily doses (10%) and dasatinib with 81,818 daily doses (6%). The percentage of CML patients receiving TKI increased from 55% in the first quarter year of 2008 to 72% in the last quarter year of 2013. 1534 patients were observed for at least four quarter years between 2008 and 2013. At median, they received 64 doses of TKI per quarter year. 1209 patients (78.8%) were treated with TKI. Only 711 patients (46.3%) received more than 67.5 daily doses, thereof 71 (4.6%) with more than 100 daily doses per quarter year. The latter are supposed to be patients with a high-dose imatinib treatment. Out of the 325 patients that did not receive any TKI, 293 (90.2%) were treated with Hydroxyurea, only 14 patients (4.3%) received Interferon. When stratifying for age group and sex, we found that for the males, the median number of daily doses in patients that actually received TKI sank from 88 doses per quarter year for patients younger than 20 years to a median of 72 daily doses for patients of 80 years and older. For women the median number of daily TKI doses was generally lower than for men. Here the highest median number of daily doses per quarter year was reached between 50 and 69 years with 80 doses and decreased to 58 in the oldest patients. However, the percentage of patients that did not receive any TKI increased steadily with age. While all patients below 20 years received TKI, 46% of the males and 43% of the women in the oldest age group of 80 years and above did not get any TKI treatment. In total, 429 (28.0%) of the patients received any second-generation TKI. The use of second-generation TKI did not depend on age or sex. Discussion Our analyses have shown, that even in the most prosperous part of a highly developed country with an extensive statutory health insurance system, still a considerable number of CML patients did not receive the adequate treatment. We found that especially elderly patients were often treated with Hydroxyurea only. There might be various reasons, as especially elderly patients might suffer from other malignancies, but also an underestimation of the patient's remaining life expectancy by the physician, resulting in withholding the expensive treatment to the elderly. Besides, it was noteworthy that women received a lower median dose than men. As it has been repeatedly shown that too low doses of treatment with TKI are accompanied with less therapeutic success, patients and physicians need to be motivated to take more care for administering the required doses over time. It has been shown that this may even be cost effective as poor adherence with TKI treatment results in higher health care costs. Disclosures No relevant conflicts of interest to declare.
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Ajjan, Nour, and Sian Shenton. "COMPARING ORAL PARACETAMOL DOSES IN PAEDIATRICS WITH THE NEW BNF-C DOSING." Archives of Disease in Childhood 101, no. 9 (August 17, 2016): e2.8-e2. http://dx.doi.org/10.1136/archdischild-2016-311535.16.
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The BNF-C 2014–20151 highlighted some key changes to the dosing of paracetamol in paediatrics, including a change in maximum daily dosage of oral paracetamol from 90 mg/kg/day to 75 mg/kg/day for post-operative pain, and inclusion of age-banded dosing for pain and pyrexia.The local Trust Paediatric Acute Pain Management Manual2 has acknowledged this change, but advised a maximum daily dose of 80 mg/kg/day. This audit was undertaken to determine whether national proposed changes were implemented in practice, in comparison with local guidelines.AimsThe aims and objectives of the audit were to compare oral paracetamol dosing in both medical and surgical settings with the new BNF-C dosing.MethodData were collected over a two week period in September 2014, from two medical and two surgical paediatric wards. The criteria for data collection included paediatric patients above the age of one month and up to 18 years, prescribed oral paracetamol for pain or pyrexia.The following data were collected:▸ Initials of patients and age (for identification purposes and to prevent duplications)▸ Weight (to assess appropriate and safe prescribing)▸ Reason for admission (to distinguish between medical and surgical settings).ResultsData were collected from 24 medical and 48 surgical patients (age range 1 month–16 years).The key findings were:19/24 medical patients were dosed according to the BNF-C age banded guidelines; 5/24 were dosed according to weight: 3 followed the Trust Manual; 1/24 followed the BNF-C, and 1 miscellaneous. No patients had a dose exceeding 80 mg/kg/day.87% of surgical patients were dosed according to the weight based calculation, 69% of whom were within the maximum daily dose of 75 mg/kg. Of the 31% whose daily dose exceeded 75 mg/kg, all were less than 80 mg/kg/day.The Trust Pain Manual does not include the dose banding as per the BNF-C but recommends 20 mg/kg 6 hourly (max 80 mg/kg/day) for acute pain in this age group.ConclusionChildren on the medical wards were prescribed paracetamol following age banded dosing as per BNF-C, whereas surgical wards were more likely to dose by weight following the Trust Pain Manual.The Trust Pain Manual differs from the BNF-C and recommends a maximum daily dose of 80 mg/kg/day for acute severe pain, to ensure adequate pain control and minimise calculation errors. Despite the new guidance in the BNF-C, it was found that many patients were prescribed a maximal daily dose greater than 75 mg/kg/day; however no patient's daily dose exceeded 80 mg/kg/day as indicated in the Manual.The main finding from the audit was that prescribers were not aware of the change in maximal daily dose of oral paracetamol. To highlight this important point, a poster was designed and distributed amongst the medical and surgical staff on the wards, highlighting that the dose should not exceed 75 mg/kg in a 24 hour period.
Dissertations / Theses on the topic "Dosos over 80 years"
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Barboza, TÃnia de AraÃjo. "Idosos CentenÃrios, a arte de envelhecer." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7454.
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INTRODUCTION. Whereas the elderly population is increasing and that centenarians represent an ideal model of longevity, combining quantity with quality of life, the study of this age group it is essential for developing policies and programs to promote successful aging. OBJECTIVES. Understanding the factors that may be associated with living conditions and health of elderly centenarians (aged 98 years or more) in the city of Fortaleza and seek to identify whether the social support networks and family, the power over life, the personality traits and spirituality can contribute to extreme longevity. METHODS. It is an exploratory and descriptive study with qualitative approach, with the locus the city of Fortaleza, Ceara, Brazil, and as six elderly subjects aged over 98 years in a position to respond to the interview in his home. The instruments used for data collection were structured interviews and in depth, recorded and transcribed verbatim, after the participants signed a consent form. The method used for data analysis was recommended by Bardin - Content Analysis. The project followed the ethical guidelines of the National Health Council, which preserved the anonymity of the respondents for their cognominaÃÃo with names of birds. RESULTS. The reports most frequently observed and interviewed were transformed into five categories as follows: Category 1 - It was very good to my life!, Category 2 - I like it when I have to talk to, Category 3 - The friendship I value family a lot; Category 4 - The family sends my money and Category 5 - I was always charitable. CONCLUSION: the personality characteristics of the respondent, namely, extroversion, low neuroticism, kindness and consciensiosidade, the presence of family support and the subjective feeling of autonomy seem to have contributed positively to their quality of life and health. It was also observed that the respondents escaped from aging-related diseases, and maintained their independence until very advanced ages. Further studies are needed in order to understand the extreme longevity and also foster the creation of public policies for a better quality of life and support for this age group.INTRODUÃÃO. Considerando que a populaÃÃo de idosos està aumentando e que os centenÃrios representam um modelo ideal de longevidade, aliando quantidade com qualidade de vida, o estudo desse grupo etÃrio torna-se fundamental para o desenvolvimento de polÃticas e programas de promoÃÃo do envelhecimento bem-sucedido. OBJETIVOS. Compreender os fatores que podem estar associados à condiÃÃo de vida e saÃde de idosos centenÃrios (com idade igual ou superior a 98 anos) do MunicÃpio de Fortaleza e procurar identificar se as redes de apoio social e familiar, a alimentaÃÃo ao longo da vida, os traÃos da personalidade e espiritualidade podem contribuir para a longevidade extrema. MÃTODOS. à um estudo exploratÃrio e descritivo com abordagem qualitativa, tendo como locus a cidade de Fortaleza-CearÃ-Brasil, e como sujeitos seis idosos com idade acima de 98 anos em condiÃÃes de responder à entrevista realizada em seu domicilio. Os instrumentos utilizados para a coleta de dados foram entrevistas estruturadas e em profundidade, gravadas e transcritas literalmente, apÃs os participantes assinarem o Termo de Consentimento Livre e Esclarecido. O mÃtodo utilizado para a anÃlise de dados foi o preconizado por Bardin â AnÃlise de ConteÃdo. O projeto obedeceu aos preceitos Ãticos do Conselho Nacional de SaÃde, sendo o anonimato dos entrevistados preservado por sua cognominaÃÃo com nomes de pÃssaros. RESULTADOS. As falas mais freqÃentes dos entrevistados foram observadas e transformadas em cinco categorias de anÃlise: Categoria 1 â Foi muito boa a minha vida!; Categoria 2 â Gosto quando tenho com quem conversar; Categoria 3 â A amizade da famÃlia eu prezo muito; Categoria 4 â A famÃlia manda no meu dinheiro e Categoria 5 â Sempre fui caridoso. CONCLUSÃO: as caracterÃsticas da personalidade do entrevistado, a saber, extroversÃo, baixos nÃveis de neuroticismo, amabilidade e consciensiosidade; a presenÃa do suporte familiar e a sensaÃÃo subjetiva de autonomia parecem ter contribuÃdo positivamente para sua qualidade de vida e saÃde. Observou-se tambÃm que os entrevistados escaparam das doenÃas relacionadas ao envelhecimento, tendo sua autonomia mantida atà idades bem avanÃadas. Novos estudos sÃo necessÃrios, visando a compreender a longevidade extrema e tambÃm fomentar a criaÃÃo de polÃticas pÃblicas voltadas para uma melhor qualidade de vida e apoio à esta faixa etÃria.
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Hillerås, Pernilla. "Well-being among the very old : a survey on a sample aged 90 years and above /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4132-7/.
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Daujat, Julie. "Ungulate invasion on a Mediterranean island : the Cypriot Mesopotamian fallow deer over the past 10,000 years." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203404.
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ODA, KOJI, KOJIRO KUROIWA, TAKESHI AMEMIYA, MASAHIKO ANDO, and SHINJI FUKATA. "POSTOPERATIVE FUNCTION FOLLOWING RADICAL SURGERY IN GASTRIC AND COLORECTAL CANCER PATIENTS OVER 80 YEARS OF AGE : AN OBJECTION TO “AGEISM”." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16735.
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Wang, Qian. "Remembering thirty years: an exploration of the changes in values experiences over three decades by three Chinese laid-off workers." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123061.
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This study uses a life history qualitative methodology to explore the changes invalues of Chinese who belonged to a special group—the glorious workers of the 1970swho were once thought of as the proud owners of the country. However, in late 1980s,after the Opening and Reforming Policy in China, these workers were laid off. This studytraces the lives of three participants who attempted to adapt to the drastic social andeconomic changes that took place in China over a 30-year period, from Mao's era, toDeng's era, to present day China. The study contains excerpts from more than 10interviews with the three participants, translated (from Chinese to English) andtranscribed; some interviews lasted as long as 10 hours. Distinctive to the study'smethodology is the combination of photo elicitation interviews with life historyinterviews, supported by the researcher's field notes, researcher's reflective notes and narratives. Thestudy is organized chronologically, starting with the participants' youth in Mao's time,their middle age in Deng's time, and their present lives.The phenomenon of laid-off workers, as a product of the Opening and ReformingPolicy, has aroused the interest of some scholars, but little research has focused on thechanges in their personal values based on their life histories. This study has highlighted acomplex pattern of interactions between the life history and changes in values of theparticipants who experienced an abrupt and highly contrasting social status in a changingChina. Thus, this dissertation addresses the influences on a lifetime of living in rapidlychanging historical eras impacted by the contrasting values of collectivism andindividualism, traditional and modern (Western) values, and situates its findings withinthe recent work in curriculum studies.Cette étude use d'une méthodologie qualitative d'histoire biographique pourexplorer les changements des valeurs de Chinois qui ont appartenu à un groupeparticulier: les glorieux travailleurs des années 1970 qui ont été considérés comme lesfiers détenteurs du pays. Toutefois, vers la fin des années 1980, après les politiques deréforme et d'ouverture en Chine, ces travailleurs furent mis à pied. Cette étude se penchesur la vie de ces participants qui tentèrent de s'adapter aux drastiques changementssociaux et économiques qui eurent lieu en Chine sur une période de trente ans, de l'èreMao, à la Chine contemporaine, en passant par l'ère Deng. Cette étude contient desextraits tirés de plus d'une dizaine d'entrevues avec trois participants, traduits (du chinoisà l'anglais) et retranscrits, certaines entrevues durant jusqu'à dix heures. La combinaisonde la « photo elicitation interview » avec les entrevues de récit de vie constitue lecaractère distinctif de la méthodologie de cette étude, supportée par les notes du/de lachercheur (euse) recueillies sur le terrain, les notes réflectif de recherche et les narratifs. Cette étude est organisée chronologiquement, débutant par la jeunesse des participants autemps de Mao, leur âge moyen à l'époque de Deng et leur vies présentes.Le phénomène des travailleurs mis à pied, en tant que produit de la politique desréformes et d'ouverture, a suscité l'intérêt de certains chercheurs, mais peu de recherchesont porté sur les changements des valeurs personnelles en se basant sur l'histoire de vie.Cette étude a souligné un processus complexe d'interaction entre l'histoire vécue et leschangements dans les valeurs des participants, qui ont expérimenté des status sociauxhautement contrastants au sein d'une Chine changeante. Cette dissertation adresse lesinfluences sur toute une vie provenant du fait de vivre à une ère historique de rapideschangements portant l'empreinte des contrastes entre les valeurs de collectivisme etd'individualisme, valeurs traditionnelles et modernes (occidentales), et situe sesconclusions au sein des récents travaux dans le domaine des études de curriculum.
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Ma, Denise. "Self-criticism and personal standards dimensions of perfectionism and subjective well-being over three years: the mediating role of basic psychological needs." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104668.
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This study of community adults (N = 164) examined the role of basic psychological needs in the relation between self-criticism (SC) and personal standards (PS) dimensions of perfectionism and subjective well-being over three years. Participants completed in-lab questionnaires assessing dimensions of perfectionism, needs satisfaction, and subjective well-being at Time 1, Year 2, and Year 3, respectively. In contrast to PS, SC was related to lower satisfaction of needs for relatedness, competence, and autonomy at Year 2; and lower life satisfaction, vitality, and positive affect, and higher negative affect at Year 3. Path analyses demonstrated that all three needs at Year 2 mediated the relation between Time 1 SC and lower life satisfaction and vitality at Year 3. These findings demonstrate the importance of trying to increase the satisfaction of the basic psychological needs in order to increase subjective well-being and reduce vulnerability to depression in individuals with higher self-critical perfectionism.Cette étude d'adultes de la communauté (N = 164) a examiné le rôle des besoins psychologiques fondamentaux dans la relation entre l'autocritique (SC) et les standards personnelle (PS) dimensions du perfectionnisme et du bien-être subjectif au cours de trois ans. Les participants ont rempli des questionnaires dans notre laboratoire pour évaluer les dimensions du perfectionnisme, la satisfaction des besoins, et le bien-être subjectif au Temps 1, Année 2, et Année 3, respectivement. Contrairement aux standards personnelle (PS), l'autocritique (SC) était liée à une réduite de satisfaction des besoins pour le sentiment de rapport, la compétence et l'autonomie à l'Année 2; et une réduite dans la satisfaction de la vie, la vitalité et l'affect positif et un augmentation à l'affect négatif l'Année 3. Des analyses causales ont démontré que les trois besoins à l'Année 2 sont des médiateurs de la relation entre l'autocritique (SC) à Temps 1 et la diminution dans la satisfaction de vie et la vitalité à l'Année 3. Ces résultats démontrent l'importance d'essayer d'augmenter la satisfaction des besoins psychologiques fondamentaux afin d'augmenter le bien-être subjectif et de réduire la vulnérabilité à la dépression dans les individus ayant hauts niveaux d'autocritique perfectionnisme.
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Moroz, Molly. "Self-criticism and personal standards dimentions of perfectionism and depressive and anxious symptoms over four years: daily avoidant coping and even stress as mediators." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110596.
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This study of community adults (N = 151) examined the role of avoidant coping and event stress in the relation between self-criticism (SC) and personal standards (PS) dimensions of perfectionism and depressive and anxious symptoms over four years. Participants completed questionnaires assessing perfectionism dimensions at Time 1, daily questionnaires measuring stress and coping at Month 6 and Year 3, and questionnaires assessing depressive and anxiety symptoms at Year 4. In contrast to PS, SC was consistently related to aggregated daily avoidant coping and event stress at Month 6 and Year 3, and depressive and anxious symptoms at Year 4. Structural equation modeling indicated that avoidant coping and event stress mediated the relation between SC and general depressive and anxious symptoms over four years. These findings demonstrate the importance of reducing avoidant coping and event stress appraisals in order to lower depressive and anxiety symptoms in individuals with higher self-critical perfectionism.Cette étude d'adultes de la communauté (N = 151) a examiné le rôle des réponses d'évitement au stress et les évènements de vie stressants comme médiateurs dans la relation entre l'autocritique (SC) et les standards personnelle (PS) dimensions du perfectionnisme et les symptômes dépressifs et anxieux au cours de quatre ans. Les participants ont rempli des questionnaires évaluant les dimensions du perfectionnisme à Temps 1, des questionnaires quotidiens mesurant le stress et l'adaptation au stress à 6 Mois et l'Année 3, et des questionnaires évaluant les symptômes dépressifs et anxieux à l'Année 4. Contrairement à PS, SC a été constamment liée aux réponses d'évitement du stress et les évènements de vie stressants agrégée à 6 Mois et l'Année 3, et aux symptômes dépressifs et anxieux à l'Année 4. Modélisation par équation structurelle a indiqué que les réponses d'évitement au stress et les évènements de vie stressants sont des médiateurs de la relation entre le SC et les symptômes dépressif et anxieux général au cours de quatre ans. Ces résultats démontrent l'importance de réduire les réponses d'évitement au stress et les évaluations des évènements de vie stressants afin de diminuer les symptômes dépressifs et anxieux parmi les individus qui ont des niveaux plus élevés d'autocritique perfectionnisme.
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Cruz, Idiane Rosset. "Avaliação geriátrica global dos idosos mais velhos residentes em Ribeirão Preto (SP) e Caxias do Sul (RS): indicadores para envelhecimento longevo." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/83/83131/tde-08012010-133459/.
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O Brasil está entre os países em desenvolvimento onde a faixa etária acima dos 80 anos é a que mais cresce. Este grupo tem sido pouco estudado em nosso meio, sobretudo no que tange às diferenças inter-regionais relacionadas à saúde. Trata-se de estudo epidemiológico comparativo e transversal, de idosos >= 80 anos residentes em duas comunidades. A amostra probabilística constou de dois grupos de idosos mais velhos: um de Ribeirão Preto (RP-SP), com 155 sujeitos e outro de Caxias do Sul (CS-RS), com 117 sujeitos. A coleta de dados se deu através de uma Avaliação Geriátrica Global, com entrevistas domiciliares realizadas entre maio de 2007 e setembro de 2008. O instrumento de coleta foi composto por dados demográficos e socioeconômicos, medidas antropométricas, Miniexame do Estado Mental (MEEM), Atividades Instrumentais de Vida Diária (AIVD), Medida de Independência Funcional (MIF), presença de comorbidades, Escala de Depressão Geriátrica (EDG) e estilo de vida (uso de álcool, tabagismo, nível de atividade física e avaliação da dieta). A média de idade foi de 84,4 (± 4,3) anos em RP e 85,0 (± 3,9) anos em CS. Houve predominância do sexo feminino (~ 67%), cor branca (~ 89%) e viúvos (~56%) em ambos os municípios, sem que houvesse diferenças significativas nestas variáveis. Não houve diferença importante na escolaridade média dos dois grupos, e a renda média do idoso foi maior (P = 0,020) em RP (R$ 978,2 ± 1.329,6) do que em CS (R$ 668,3 ± 596,1). Entretanto, em RP houve maior concentração de indivíduos tanto analfabetos como com alta escolaridade; bem como daqueles que recebiam tanto menos de um salário mínimo (SM) como mais de 3 SM. Verificou-se ainda uma proporção maior de idosos que utilizavam convênio de saúde em CS (63%) do que em RP (49%). Não houve diferença estatisticamente significativa no escore médio do MEEM entre os dois grupos (20,6 ± 7,5 em RP e 19,5 ± 6,3 em CS; P = 0,23), sendo que este foi significativamente menor para indivíduos do sexo feminino, com idade mais avançada e analfabetos. Verificou-se uma proporção maior de idosos independentes para as AIVD em RP (22%) do que em CS (7%; P = 0,001), bem como um escore maior na MIF naquele grupo (108,2 ± 24,3) do que em CS (102,9 ± 19,9; P = 0,058). Um melhor nível de independência em ambos os municípios foi observado para os idosos do sexo masculino, aqueles casados, de maior escolaridade e melhor renda. Houve uma tendência a uma maior proporção de idosos com sobrepeso e obesos em CS (41,9% e 21,4%, respectivamente) do que em RP (32,7% e 15,3%, respectivamente; P = 0,08). Verificou-se também maior número de comorbidades em CS (7,6 ± 2,9) do que em RP (5,9 ± 2,9; P < 0,001). Entretanto, RP apresentou maior escore na EDG (4,1 ± 2,9), com maior proporção de sujeitos depressivos (39,3%) do que CS (3,1 ± 2,8 e 22,8%, respectivamente; P = 0,005). Os idosos com menos sintomas depressivos foram aqueles do sexo masculino, casados, ou com maior escolaridade em ambos os grupos. Em ambos os municípios, após ajustar-se para idade e gênero, observouse que o grau de independência funcional (MIF) correlacionou-se positivamente com o MEEM e negativamente com o número de comorbidades e o escore na EDG. Quanto ao estilo de vida, não houve diferença significativa entre os dois grupos no que tange ao gasto energético em atividade física e ao consumo de cigarros. No entanto, em CS houve uma proporção maior de idosos que utilizam ou utilizavam bebida alcoólica, especialmente vinho. Os idosos de CS também apresentaram maior consumo calórico diário, inclusive de carboidratos, gorduras saturadas e sódio do que em RP (P < 0,001 para todos). Quando comparado a RP, embora os idosos de CS apresentem menor desigualdade educacional e de renda, além de menores índices de depressão, a dieta destes é menos saudável, há maior prevalência de obesidade e outras comorbidades e maior dependência funcional. Um adequado planejamento em termos de políticas de saúde, que melhor atendesse aos prérequisitos do envelhecimento bem-sucedido, poderia contribuir ao bem-estar dos idosos brasileiros mais velhos.Brazil is one of the developing countries where the age range over 80 years is the fastest growing population group. This group has been little studied in our context, mainly with respect to interregional health-related differences. This comparative and cross-sectional epidemiological research looked at elderly >= 80 years of age living in two communities. The probabilistic sample comprised two groups of elder elderly: one in Ribeirão Preto (RP-SP), with 155 subjects; and another in Caxias do Sul (CS-RS), including 117 subjects. Data were collected through a Comprehensive Geriatric Assessment, involving home interviews carried out between May 2007 and September 2008. The data collection instrument consisted of demographic and socioeconomic data, anthropometric measures, the Mini-Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL), Functional Independence Measure (FIM), presence of comorbidities, Geriatric Depression Scale (GDS) and lifestyle (alcohol use, smoking, level of physical activity and diet assessment). The mean age was 84.4 (± 4,3) years in RP and 85,0 (± 3,9) years in CS. Female (~ 67%), white (~ 89%) and widowed (~56%) persons predominated in both cities, without any significant differences in these variables. No important difference was found between the two groups\' mean education level, and the elderly\'s mean income was higher (P = 0.020) in RP (R$ 978,2 ± 1,329,6) than in CS (R$ 668.3 ± 596,1). In RP, a greater concentration of both illiterate people and persons with a high education level was found; and of people receiving either less than one minimum wage (MW) or more than 3 MW. Also, the proportion of elderly people with health insurance found in CS (63%) was larger than in RP (49%). No statistically significant difference was found in the mean MMSE score between both groups (20.6 ± 7.5 in RP against 19.5 ± 6.3 in CS; P = 0.23), which was significantly lower for female, older and illiterate people. A larger proportion of independent elderly in terms of IADL was found in RP (22%) when compared with CS (7%; P = 0.001), and a higher score on the FIM in RP (108.2 ± 24.3) than in CS (102.9 ± 19.9; P = 0.058). In both cities, a higher level of independence was found for male, married elderly with higher education and income levels. A larger proportion of overweight and obese elderly was found in CS (41.9% and 21.4%, respectively) than in RP (32.7% and 15.3%, respectively; P = 0.08). Also, in CS, a larger quantity of comorbidities was found (7.6 ± 2.9) than in RP (5.9 ± 2.9; P < 0.001). However, RP displayed a higher score on the GDS (4.1 ± 2.9), with a larger proportion of depressive subjects (39.3%) than in CS (3.1 ± 2.8 and 22.8%, respectively; P = 0.005). In both groups, male, married elderly with higher education levels showed less depressive symptoms. In both cities, after adjusting for age and gender, a positive correlation was observed between the level of FIM and the MMSE, and a negative correlation with the number of comorbidities and the GDS score. As for lifestyle, no significant differences were found between both groups in terms of energy spent on physical activity and smoking. However, in CS, a larger proportion of elderly was found who were consuming or had consumed alcohol, especially wine. Elderly in CS also presented higher daily consumption levels of calories, carbohydrates, saturated fats and sodium than in RP (P < 0.001 for all). In comparison with RP, although elderly in CS demonstrated less inequality in terms of education and income and lower depression rates, their diet is less healthy and prevalence levels of obesity, other comorbidities and functional dependence are higher. Thus, efforts can me made to adequately plan health policies with a view to better complying with the prerequisites of successful aging and providing greater wellbeing to the Brazilian oldest-old.
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Bejan-Angoulvant, Theodora. "Analyse de la réduction du risque cardiovasculaire par le traitement antihypertenseur : vers une prescription personnalisée." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10232.
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Le traitement antihypertenseur (TAH) réduit le risque cardiovasculaire (RCV). Son efficacité est établie à partir de nombreux essais et méta-analyses conduits sur différentes populations. L’effet du TAH suit en moyenne un modèle multiplicatif différent d’une classe médicamenteuse à l’autre et non constant dans le temps. Pour progresser vers une prescription personnalisée du TAH, nous avons suivi 3 objectifs: 1) La modélisation statistique de l’effet du TAH sur le risque d’accidents vasculaires cérébraux (AVC) et d’infarctus (IDM) dans différents sous-groupes de patients, selon le temps et la classe médicamenteuse. 2) La méta-analyse de l’effet du TAH sur le risque d’AVC, d’IDM et de mortalité après 80 ans, situation de prescription fréquente. 3) La mise en place, conduite et coordination de l’essai clinique IDEAL, randomisé en plan croisé et double insu dont l’objectif est d’étudier l’influence des caractéristiques individuelles sur la réponse pressionnelle à 2 classes de TAH. Les 2 premiers travaux ont été réalisés sur la base INDANA, méta-analyse sur données individuelles des essais évaluant le TAH contre placebo. Ils suggèrent sans être définitivement convaincants que la réduction du bénéfice au cours du temps sur le risque d’infarctus est plus nette chez la femme et sous bêtabloquants. Chez les patients très âgés le TAH reste efficace pour réduire le RCV, mais notre analyse de l’absence de réduction de la mortalité nous conduit à recommander d’éviter toute intensification du TAH à cet âge. L’essai IDEAL a inclus 124 patients chez lesquels la régression à la moyenne et l’évolution sous placebo expliquent une baisse de pression de même ordre que le TAHAntihypertensive treatment (AHT) reduces cardiovascular risk (CVR). Its efficacy is well established from numerous clinical trials and meta-analysis conducted in several populations. The AHT effect follows on average a multiplicative model. This model is different from one drug class to another, and is not constant during follow-up.In order to progress towards a personalized prescription of AHT, we followed 3 objectives: 1) The statistical modelling of AHT effect on stroke (ST) and myocardial infarction (MI) in different sub-groups of patients,depending on time of follow-up and first line drug class. 2) The meta-analysis of AHT effect on the risk of stroke,MI and total mortality in patients ages 80 years and older in whom AHT is frequently prescribed. 3) The set-up,conduct and coordination of the IDEAL study, a cross-over randomized double blind clinical trial in order to assess the influence of individual characteristics on blood pressure (BP) response to two AHT drug classes. The first two analyses were performed on the INDANA database, an individual patient data meta-analysis from trials that evaluated the effect of AHT against placebo. These analyses suggest that the decreased benefit of AHT over timeon MI prevention was mostly apparent in women and with first line beta-blocker. Treatment remained efficient invery old patients in reducing CVR, but the lack of mortality reduction led us not to recommend AHT intensificationin this age group. The IDEAL study included 124 patients for which the regression to the mean and the evolution under placebo phenomena explained a BP reduction similar to the one under AHT
Books on the topic "Dosos over 80 years"
1
Geoffrey, Jellicoe. The studies of a landscape designer over 80 years. Woodbridge: Garden Art Press, 1993.
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Monro, Kate. Losing it: How we popped our cherry over the last 80 years. London: Icon, 2013.
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Jellicoe, Geoffrey Alan. Geof frey Jellicoe: The studies of a landscape designer over 80 years. Woodbridge, Suffolk: Garden Art Press, 1993.
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Anderton, George. A brotherhood in song: A history of the Haydock Male Voice Choir over the 80 years 1923-2003. [Haydock?]: H.M.V.C. Publications, 2003.
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Chant, Edna B. Edna's scrapbook: Over 80 years of exciting happenings in the united counties of Leeds and Grenville and immediate area. Gananoque, Ont: Thousand Islands, 1988.
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Johnson, Colleen Leahy. Life beyond 85 years. Amherst, N.Y: Prometheus Books, 2003.
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Officer, Great Britain Department of Health Chief Medical. Adult immunisation update: (i) introduction of a pneumococcal immunisation programme for those aged 80 years and over : (ii) influenza immunisation programme 2003/2004. London: Department of Health, 2003.
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M, Barer Barbara, ed. Life beyond 85 years: The aura of survivorship. New York: Springer Pub. Co., 1997.
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Monro, Kate. Losing It: How We Popped Our Cherry over the Last 80 Years. Icon Books, Limited, 2013.
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Mishra, Priyanka, and Rajender Singh. "Seminal Decline in Semen Quality in Humans Over the Last 80 years." In Male Infertility: Understanding, Causes and Treatment, 89–108. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4017-7_7.
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AlTurki, Ahmed, Riccardo Proietti, and Francesco Borgia. "Quality of Life of Patients Over 80 Years Old with Implantable Cardioverter-Defibrillators." In Psychological, Emotional, Social and Cognitive Aspects of Implantable Cardiac Devices, 209–17. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55721-2_12.
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Legrand, Michel, Martine de Angelis, Hélène Cachier, and Annie Gaudichet. "Boreal Biomass Burning Over the Last 80 Years Recorded in a Summit-Greenland Ice Core." In Ice Core Studies of Global Biogeochemical Cycles, 347–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-51172-1_18.
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Birn, G., and M. Stallmach. "Is High Dose Nimodipine Therapy Necessary Following Subarachnoid Hemorrhage? A Retrospective Study of 80 Patients with Aneurysmal Subarachnoid Hemorrhage over the Past 2 Years." In Stabilizing Craniocervical Operations Calcium Antagonists in SAH Current Legal Issues, 185–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75283-4_31.
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Beaudry-Godin, Mélissa, Robert Bourbeau, and Bertrand Desjardins. "Extreme Longevity in Quebec: Factors and Characteristics." In Demographic Research Monographs, 169–90. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49970-9_12.
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AbstractThe recent decrease in adult and late-life mortality led to a very rapid increase in the number of centenarians within low mortality countries. This chapter examines the increase in the number of centenarians in Quebec (Canada) across birth cohorts (1871–1901), and outlines some of the underlying demographic mechanisms involved. We study the demographic situation of centenarians from Quebec (Canada) using all aggregated data available since 1871 (census data, vital statistics, and population estimations). Census data and population estimates are taken from Statistics Canada, while vital statistics come from the Canadian Human Mortality Database (CHMD, 2014 www.bdlc.umontreal.ca) and the Institut de la statistique du Québec.With demographic indicators such as the centenarian ratio, the survival probabilities and the maximal age at death, we try to demonstrate the remarkable progress realised in old age mortality. We also analyze the determinants of the increase in the number of centenarians in Quebec: increase in the size of birth cohorts, increase in the probabilities of surviving from birth to age 80 and from age 80 to 100 for specific cohorts, change in the number of persons aged 100 and over relative to the number of persons reaching exact age 100 and net change due to migration and other factors (errors). This decomposition shows that, among the factors identified, the improvement in late-life mortality (from age 80 to 100) is the main determinant of the increase of the number of centenarians.This study stresses the importance of monitoring the number as well as the quality of life of this emerging population of centenarians. It also helps us gain greater perspective on what should be expected in the coming years among low mortality countries such as Canada.
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Wong, Man Sing, Xiaolin Zhu, Sawaid Abbas, Coco Yin Tung Kwok, and Meilian Wang. "Optical Remote Sensing." In Urban Informatics, 315–44. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8983-6_20.
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AbstractApplications of Earth-observational remote sensing are rapidly increasing over urban areas. The latest regime shift from conventional urban development to smart-city development has triggered a rise in smart innovative technologies to complement spatial and temporal information in new urban design models. Remote sensing-based Earth-observations provide critical information to close the gaps between real and virtual models of urban developments. Remote sensing, itself, has rapidly evolved since the launch of the first Earth-observation satellite, Landsat, in 1972. Technological advancements over the years have gradually improved the ground resolution of satellite images, from 80 m in the 1970s to 0.3 m in the 2020s. Apart from the ground resolution, improvements have been made in many other aspects of satellite remote sensing. Also, the method and techniques of information extraction have advanced. However, to understand the latest developments and scope of information extraction, it is important to understand background information and major techniques of image processing. This chapter briefly describes the history of optical remote sensing, the basic operation of satellite image processing, advanced methods of object extraction for modern urban designs, various applications of remote sensing in urban or peri-urban settings, and future satellite missions and directions of urban remote sensing.
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"Aortic Valve Replacement in Patients Aged Over 80 Years." In Degenerative Aortic Valve Disease, its Mechanism on Progression, its Effect on the Left Ventricle and the Postoperative Results, edited by Wilhelm Peter Mistiaen, 224–38. BENTHAM SCIENCE PUBLISHERS, 2013. http://dx.doi.org/10.2174/9781608052875113010012.
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Kreissig, Ingrid, and Harvey Lincoff. "Primary Retinal Detachment: Review of Techniques for Repair Applied Over the Past 80 Years—A Personal Odyssey." In Principles and Practice of Vitreoretinal Surgery, 216. Jaypee Brothers Medical Publishers (P) Ltd., 2014. http://dx.doi.org/10.5005/jp/books/12210_27.
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Tam, Derrick Y., Reena Karkhanis, and Stephen E. Fremes. "Coronary artery bypass grafting in octogenarians." In State of the Art Surgical Coronary Revascularization, edited by Naresh Trehan and Yasir Abu-Omar, 411–14. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198758785.003.0070.
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The prevalence of coronary artery disease in the elderly is high and has been shown to be greater than 80% in patients over the age of 80 years. Coronary artery bypass grafting remains the treatment of choice in selected patients with advanced coronary disease in the absence of surgical contraindications. While much of the data presented in this chapter is not from the current decade, there are some recent studies that have examined trends and outcomes in the contemporary era.
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Sista, Ramachandra R. "Critical Care of Heart-Lung and Lung Transplant Recipients." In Mayo Clinic Critical and Neurocritical Care Board Review, edited by Eelco F. M. Wijdicks, James Y. Findlay, William D. Freeman, and Ayan Sen, 446–52. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190862923.003.0071.
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Lung transplant is a complex procedure that has been a successful therapy for various end-stage lung diseases since the 1980s. Combined heart-lung transplant, however, is performed much less frequently than in the past. Survival rates after lung transplant have been stable over the past several years (90% survival at 3 months, 80% at 1 year, 60% at 3 years, and 45% at 5 years). The types of transplant procedures available and the general indications for lung transplant are listed in this chapter.
Conference papers on the topic "Dosos over 80 years"
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Rocha, AC, MI Sá, S. Raposo, R. Sousa, P. Correia, P. Aldinhas, E. Branco, C. Coelho, V. Baltar, and L. Sá. "EP226 The advancing age: breast cancer over 80 years." In ESGO Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-esgo.288.
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Gray, John Malcolm. "DEVELOPMENT OF X-80 HTP LINEPIPE STEEL OVER 40 YEARS." In 69° Congresso Anual da ABM - Internacional. São Paulo: Editora Blucher, 2014. http://dx.doi.org/10.5151/1516-392x-24347.
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Moriyama, Akari, Ken-ichi Takahashi, Susumu Noguchi, Shohei Kaneda, Kazuhiko Nakagawa, Yuichi Higami, Yoichiro Yutaka, et al. "Prognostic Factors Of Pneumonia In The Elderly Aged Over 80 Years." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4842.
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Mensah, Shirley Tsotsoo. "MORPHOLOGICAL CHANGES ON EASTERN ILLINOIS UNIVERSITY CAMPUS OVER THE PAST 80 YEARS." In GSA Annual Meeting in Indianapolis, Indiana, USA - 2018. Geological Society of America, 2018. http://dx.doi.org/10.1130/abs/2018am-323866.
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Schuermans, Daniel, Aziz Debain, Ivan Bautmans, Shane Hanon, and Eef Vanderhelst. "Is spirometry easy to perform, even when you are over 80 years old?" In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa3906.
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Couturier, H., A. Cuvelier, M. Patout, J. Dupuis, and Z. Gharsallaoui. "Home Noninvasive Ventilation Setup in Patients Over 80 Years Old: Outcome and Compliance." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6208.
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Takaku, Takio, Takefumi Saito, Kenji Nemoto, Shuji Oisihi, and Kenji Hayashihara. "Comparison of adverse effects in tuberculosis patients over 80 years of age with and without pyrazinamide treatment." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa3045.
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Norris, Patrick J., and John Cunningham. "Gas Turbine Application Over Thirty Years in a Middle East Oil Production Facility." In ASME 1988 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1988. http://dx.doi.org/10.1115/88-gt-249.
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Kuwait Oil Company (KOC) has installed and operated gas turbines since 1957. There are currently 79 Gas Turbines ranging in size from 700 to 33,000 H.P. of various types, from industrial to aero-derivative. Gas turbines provide more than half a million in horsepower, which is more than 80% of the power, for machinery and power generation at KOC. This paper covers the introduction and the rappid growth of gas turbine power at KOC. Operational sites at KOC are subject to severe heat, dust and humidity. The experience in the operation and maintenance in the early years of the gas turbines at KOC are described. Gas turbines have played a major role in the success of the Company.
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Nakamura, R., H. Matsuzaki, M. Sakamoto, K. Suda, S. Hayama, and T. Sangai. "Abstract P1-07-15: The outcomes for super elderly patients over 80 years old after breast cancer surgery." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p1-07-15.
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Accordini, Simone, Pierpaolo Marchetti, Alessandro Marcon, Giancarlo Pesce, Lucia Calciano, Christer Janson, Deborah Jarvis, et al. "Trends of asthma incidence over 80 years in Europe: preliminary results from the Ageing Lungs in European Cohorts (ALEC) study." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.2601.
Full textReports on the topic "Dosos over 80 years"
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Margenau, Eric, and Lenza Paul. A 23-year summary of a Monitoring Avian Productivity and Survivorship (MAPS) bird banding site in New River Gorge National River, West Virginia. National Park Service, August 2021. http://dx.doi.org/10.36967/nrr-2287051.
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Long-term bird banding data were collected from 1996–2019 (except in 2008) to assess the New River riparian zone avian community in one location in New River Gorge National River (NERI). The NERI banding station has banded over 4,500 individuals over 10,700 net hours in the twenty-three years it has been in operation and has captured 80 different species. Total captures, capture rate, and total species have been declining annually over the study period. Species associated with early-successional/shrubland habitat also declined over the study period, which is consistent with regional trends during the same time frame. Species richness of habitat guilds did not change over the study period within specific major habitat types. Capture metrics of Louisiana Waterthrush, an obligate riparian species, did increase over the study period. Continued banding will further provide information to assist in local management and contribute to regional data.
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Hicks, Julie, Laurin Yates, and Jackie Pettway. Mat Sinking Unit supply study : Mississippi River revetment. Engineer Research and Development Center (U.S.), September 2021. http://dx.doi.org/10.21079/11681/41867.
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The Mississippi Valley Division (MVD) has maintained the Mississippi River banks for over 80 years. The Mat Sinking Unit (MSU), built in 1946, was considered state-of-the-art at the time. This system is still in operation today and has placed over 1,000 miles of Articulated Concrete Mats along the Mississippi River from Head of Passes, LA, to Cairo, IL. A new MSU has been designed and is expected to be fully mission capable and operational by the 2023 season, which is expected to increase the productivity from 2,000 squares/day up to 8,000 squares/day with double shifts and optimal conditions. This MSU supply study identifies and optimizes the supply chain logistics for increased production rates from the mat fields to the MSU. The production rates investigated for this effort are 2,000 squares/day, 4,000 squares/day, and 6,000 squares/day. RiskyProject® software, which utilizes a Monte Carlo method to determine a range of durations, manpower, and supplies based on logical sequencing is used for this study. The study identifies several potential supply and demand issues with the increased daily production rates. Distance to casting fields, number of barges, and square availability are the major issues to supply increased placement rates identified by this study.