Relevant bibliographies by topics / DOTA/NOTA

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'DOTA/NOTA'

Author: Grafiati
Published: 7 July 2024
Last updated: 31 July 2025

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Journal articles on the topic "DOTA/NOTA"

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Haeger, Arlette, Cristian Soza-Ried, Vasko Kramer, et al. "Al[18F]F-NOTA-Octreotide Is Comparable to [68Ga]Ga-DOTA-TATE for PET/CT Imaging of Neuroendocrine Tumours in the Latin-American Population." Cancers 15, no. 2 (2023): 439. http://dx.doi.org/10.3390/cancers15020439.

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PET imaging of neuroendocrine tumours (NET) is well established for staging and therapy follow-up. The short half-life, increasing costs, and regulatory issues significantly limit the availability of approved imaging agents, such as [68Ga]Ga-DOTA-TATE. Al[18F]F-NOTA-Octreotide provides a similar biodistribution and tumour uptake, can be produced on a large scale and may improve access to precision imaging. Here we prospectively compared the clinical utility of [68Ga]Ga-DOTA-TATE and Al[18F]F-NOTA-Octreotide in the Latin-American population. Our results showed that in patients with stage IV NET
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Dam, Johan Hygum, Niels Langkjær, Christina Baun, Birgitte Brinkmann Olsen, Aaraby Yoheswaran Nielsen, and Helge Thisgaard. "Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC." Molecules 27, no. 20 (2022): 6818. http://dx.doi.org/10.3390/molecules27206818.

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Background: The somatostatin receptors 1–5 are overexpressed on neuroendocrine neoplasms and, as such, represent a favorable target for molecular imaging. This study investigates the potential of [18F]AlF-NOTA-[1-Nal3]-Octreotide and compares it in vivo to DOTA- and NOTA-[1-Nal3]-Octreotide radiolabeled with gallium-68. Methods: DOTA- and NOTA-NOC were radiolabeled with gallium-68 and NOTA-NOC with [18F]AlF. Biodistributions of the three radioligands were evaluated in AR42J xenografted mice at 1 h p.i and for [18F]AlF at 3 h p.i. Preclinical PET/CT was applied to confirm the general uptake pat
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Lee, Inki, Min Hwan Kim, Kyongkyu Lee, et al. "Comparison of the Effects of DOTA and NOTA Chelators on 64Cu-Cudotadipep and 64Cu-Cunotadipep for Prostate Cancer." Diagnostics 13, no. 16 (2023): 2649. http://dx.doi.org/10.3390/diagnostics13162649.

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Background: This study compared the effects of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) as 64Cu-chelating agents in newly developed prostate-specific membrane antigen (PSMA) target compounds, 64Cu-cudotadipep and 64Cu-cunotadipep, on pharmacokinetics. Methods: The in vitro stability of the chelators was evaluated using human and mouse serum. In vitro PSMA-binding affinity and cell uptake were compared using human 22Rv1 cells. To evaluate specific PSMA-expressing tumor-targeting efficiency, micro-positron emission to
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Kis, Adrienn, Judit P. Szabó, Noémi Dénes, et al. "In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography." BioMed Research International 2020 (August 7, 2020): 1–10. http://dx.doi.org/10.1155/2020/4952372.

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Introduction. Hypoxia-induced ανβ3 integrin and aminopeptidase N (APN/CD13) receptor expression play an important role in tumor neoangiogenesis. APN/CD13-specific 68Ga-NOTA-c(NGR), ανβ3 integrin-specific 68Ga-NODAGA-[c(RGD)]2, and hypoxia-specific 68Ga-DOTA-nitroimidazole enable the in vivo detection of the neoangiogenic process and the hypoxic regions in the tumor mass using positron emission tomography (PET) imaging. The aim of this study was to evaluate whether 68Ga-NOTA-c(NGR) and 68Ga-DOTA-nitroimidazole allow the in vivo noninvasive detection of the temporal changes of APN/CD13 expressio
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Drahoš, Bohuslav, Vojtěch Kubíček, Célia S. Bonnet, Petr Hermann, Ivan Lukeš, and Éva Tóth. "Dissociation kinetics of Mn2+ complexes of NOTA and DOTA." Dalton Transactions 40, no. 9 (2011): 1945. http://dx.doi.org/10.1039/c0dt01328e.

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Poulie, Christian B. M., Jesper T. Jørgensen, Vladimir Shalgunov, et al. "Evaluation of [64Cu]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts—Comparison to [111In]In-DOTA-PEG11-BisPy-Tz." Molecules 26, no. 3 (2021): 544. http://dx.doi.org/10.3390/molecules26030544.

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Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [64Cu]Cu-NOTA-PEG7-H-Tz using a setup we previously used for [111In]In-DOTA-PEG11-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison
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7

Jussing, Emma, Stefan Milton, Erik Samén, et al. "Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers." Biomolecules 11, no. 8 (2021): 1118. http://dx.doi.org/10.3390/biom11081118.

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By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different chelators, which negatively affects the radiolabeling yields. In this work, we significantly lowered the level of iron (Fe) impurities by adding ascorbate in the purification, and the resulting 68GaCl3could be utilized for high-yield radiolabeling of clinically relevant DOTA-based tracers. 68GaCl3 was cyclotron-produced and purified with ascorbate added in the was
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Milton, Stefan, Emma Jussing, Klas Bratteby, et al. "First time evaluation of 45Ti for radiolabeling of NOTA and DOTA chelators." Nuclear Medicine and Biology 126-127 (November 2023): 108721. http://dx.doi.org/10.1016/j.nucmedbio.2023.108721.

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9

Ranyuk, Elena, Réjean Lebel, Yves Bérubé-Lauzière, et al. "68Ga/DOTA- and 64Cu/NOTA-Phthalocyanine Conjugates as Fluorescent/PET Bimodal Imaging Probes." Bioconjugate Chemistry 24, no. 9 (2013): 1624–33. http://dx.doi.org/10.1021/bc400257u.

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10

Alex Brown, M., Thomas Brossard, and David A. Rotsch. "Examination of lutetium(III)-DOTA and copper(II)-NOTA solution structures using EXAFS." Inorganica Chimica Acta 482 (October 2018): 118–21. http://dx.doi.org/10.1016/j.ica.2018.05.031.

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Dissertations / Theses on the topic "DOTA/NOTA"

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Graves, S., H. Valdovinos, W. Cai, T. Barnhart, and R. Nickles. "Pursuit of purity: Measurement of chelation binding affinities for NOTA, DOTA, and desferal with applications to effective specific activity." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166419.

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Introduction The effective specific activity of a radioisotope is an indirect and highly useful way to describe a radioactive sample’s purity. A high effective specific activity combines the concept of an isotopically pure product with suitability via selectivity of a particular chelating body. The primary goals of this work are twofold: 1) To determine which metallic impurities have the largest impact on the effective specific activity for a given chelator, and 2) to form a model based on the binding affinities of each metal for to calculate a ‘theoretical effective specific activ-ity’ from b
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Gaillard, Michel. "Nouveaux marqueurs électroactifs pour le développement de biocapteurs environnementaux." Electronic Thesis or Diss., Perpignan, 2023. https://theses-public.univ-perp.fr/2023PERP0054.pdf.

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De nos jours, l'évolution du climat, les rejets anthropiques et l’augmentation de la population mondiale concourent à un accroissement du nombre de bactéries préoccupantes, des rejets médicamenteux et des toxines dans l’environnement. L’ochratoxine A, l’estradiol, et certaines bactéries font partie des contaminants polluant la nature et menaçant la santé des êtres vivants. Dans une optique de détection de ces éléments potentiellement dangereux, nous avons travaillé sur le développement d’un marquage original d'oligonucléotides. Ce marquage est basé sur l’utilisation de complexes métalliques él
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Blom, Elisabeth. "Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108629.

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This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. A few applications were explored using molecular design perspectives. A nucleophilic 18F-labelling strategy using perfluoro-containing leaving groups was explored. We observed that [18F]fluoride was interacting with the perfluoro alkyl chains of the substrate,
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Book chapters on the topic "DOTA/NOTA"

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Dijkgraaf, Ingrid, Stijn M. Agten, Matthias Bauwens, and Tilman M. Hackeng. "Strategies for Site-Specific Radiolabeling of Peptides and Proteins." In Radiopharmaceuticals [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99422.

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Although anatomical imaging modalities (X-ray, computed tomography (CT), magnetic resonance imaging (MRI)) still have a higher spatial resolution (0.1–1 mm) than molecular imaging modalities (single-photon emission computed tomography (SPECT), positron emission tomography (PET), optical imaging (OI)), the advantage of molecular imaging is that it can detect molecular and cellular changes at the onset of a disease before it leads to morphological tissue changes, which can be detected by anatomical imaging. During the last decades, noninvasive diagnostic imaging has encountered a rapid growth du
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Conference papers on the topic "DOTA/NOTA"

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Kjaer, A., M. Persson, D. Skovgaard, et al. "Abstract P5-01-04: uPAR PET imaging in breast cancer: First-in-humans studies using 64Cu-DOTA-AE105 and 68Ga-NOTA-AE105." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p5-01-04.

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