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Journal articles on the topic 'DOTA/NOTA'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Haeger, Arlette, Cristian Soza-Ried, Vasko Kramer, et al. "Al[18F]F-NOTA-Octreotide Is Comparable to [68Ga]Ga-DOTA-TATE for PET/CT Imaging of Neuroendocrine Tumours in the Latin-American Population." Cancers 15, no. 2 (2023): 439. http://dx.doi.org/10.3390/cancers15020439.

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PET imaging of neuroendocrine tumours (NET) is well established for staging and therapy follow-up. The short half-life, increasing costs, and regulatory issues significantly limit the availability of approved imaging agents, such as [68Ga]Ga-DOTA-TATE. Al[18F]F-NOTA-Octreotide provides a similar biodistribution and tumour uptake, can be produced on a large scale and may improve access to precision imaging. Here we prospectively compared the clinical utility of [68Ga]Ga-DOTA-TATE and Al[18F]F-NOTA-Octreotide in the Latin-American population. Our results showed that in patients with stage IV NET

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2

Dam, Johan Hygum, Niels Langkjær, Christina Baun, Birgitte Brinkmann Olsen, Aaraby Yoheswaran Nielsen, and Helge Thisgaard. "Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC." Molecules 27, no. 20 (2022): 6818. http://dx.doi.org/10.3390/molecules27206818.

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Background: The somatostatin receptors 1–5 are overexpressed on neuroendocrine neoplasms and, as such, represent a favorable target for molecular imaging. This study investigates the potential of [18F]AlF-NOTA-[1-Nal3]-Octreotide and compares it in vivo to DOTA- and NOTA-[1-Nal3]-Octreotide radiolabeled with gallium-68. Methods: DOTA- and NOTA-NOC were radiolabeled with gallium-68 and NOTA-NOC with [18F]AlF. Biodistributions of the three radioligands were evaluated in AR42J xenografted mice at 1 h p.i and for [18F]AlF at 3 h p.i. Preclinical PET/CT was applied to confirm the general uptake pat

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3

Lee, Inki, Min Hwan Kim, Kyongkyu Lee, et al. "Comparison of the Effects of DOTA and NOTA Chelators on 64Cu-Cudotadipep and 64Cu-Cunotadipep for Prostate Cancer." Diagnostics 13, no. 16 (2023): 2649. http://dx.doi.org/10.3390/diagnostics13162649.

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Background: This study compared the effects of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) as 64Cu-chelating agents in newly developed prostate-specific membrane antigen (PSMA) target compounds, 64Cu-cudotadipep and 64Cu-cunotadipep, on pharmacokinetics. Methods: The in vitro stability of the chelators was evaluated using human and mouse serum. In vitro PSMA-binding affinity and cell uptake were compared using human 22Rv1 cells. To evaluate specific PSMA-expressing tumor-targeting efficiency, micro-positron emission to

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4

Kis, Adrienn, Judit P. Szabó, Noémi Dénes, et al. "In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography." BioMed Research International 2020 (August 7, 2020): 1–10. http://dx.doi.org/10.1155/2020/4952372.

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Introduction. Hypoxia-induced ανβ3 integrin and aminopeptidase N (APN/CD13) receptor expression play an important role in tumor neoangiogenesis. APN/CD13-specific 68Ga-NOTA-c(NGR), ανβ3 integrin-specific 68Ga-NODAGA-[c(RGD)]2, and hypoxia-specific 68Ga-DOTA-nitroimidazole enable the in vivo detection of the neoangiogenic process and the hypoxic regions in the tumor mass using positron emission tomography (PET) imaging. The aim of this study was to evaluate whether 68Ga-NOTA-c(NGR) and 68Ga-DOTA-nitroimidazole allow the in vivo noninvasive detection of the temporal changes of APN/CD13 expressio

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5

Drahoš, Bohuslav, Vojtěch Kubíček, Célia S. Bonnet, Petr Hermann, Ivan Lukeš, and Éva Tóth. "Dissociation kinetics of Mn2+ complexes of NOTA and DOTA." Dalton Transactions 40, no. 9 (2011): 1945. http://dx.doi.org/10.1039/c0dt01328e.

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6

Poulie, Christian B. M., Jesper T. Jørgensen, Vladimir Shalgunov, et al. "Evaluation of [64Cu]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts—Comparison to [111In]In-DOTA-PEG11-BisPy-Tz." Molecules 26, no. 3 (2021): 544. http://dx.doi.org/10.3390/molecules26030544.

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Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [64Cu]Cu-NOTA-PEG7-H-Tz using a setup we previously used for [111In]In-DOTA-PEG11-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison

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7

Jussing, Emma, Stefan Milton, Erik Samén, et al. "Clinically Applicable Cyclotron-Produced Gallium-68 Gives High-Yield Radiolabeling of DOTA-Based Tracers." Biomolecules 11, no. 8 (2021): 1118. http://dx.doi.org/10.3390/biom11081118.

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By using solid targets in medical cyclotrons, it is possible to produce large amounts of 68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals compete with Ga3+ in the complexation with different chelators, which negatively affects the radiolabeling yields. In this work, we significantly lowered the level of iron (Fe) impurities by adding ascorbate in the purification, and the resulting 68GaCl3could be utilized for high-yield radiolabeling of clinically relevant DOTA-based tracers. 68GaCl3 was cyclotron-produced and purified with ascorbate added in the was

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8

Milton, Stefan, Emma Jussing, Klas Bratteby, et al. "First time evaluation of 45Ti for radiolabeling of NOTA and DOTA chelators." Nuclear Medicine and Biology 126-127 (November 2023): 108721. http://dx.doi.org/10.1016/j.nucmedbio.2023.108721.

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9

Ranyuk, Elena, Réjean Lebel, Yves Bérubé-Lauzière, et al. "68Ga/DOTA- and 64Cu/NOTA-Phthalocyanine Conjugates as Fluorescent/PET Bimodal Imaging Probes." Bioconjugate Chemistry 24, no. 9 (2013): 1624–33. http://dx.doi.org/10.1021/bc400257u.

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10

Alex Brown, M., Thomas Brossard, and David A. Rotsch. "Examination of lutetium(III)-DOTA and copper(II)-NOTA solution structures using EXAFS." Inorganica Chimica Acta 482 (October 2018): 118–21. http://dx.doi.org/10.1016/j.ica.2018.05.031.

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11

Hrynchak, Ivanna, Diana Cocioabă, Alexandra I. Fonseca, et al. "Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach." Molecules 28, no. 12 (2023): 4670. http://dx.doi.org/10.3390/molecules28124670.

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Antibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of copper-64 using solid targets has been established for many years, its use is limited due to the complexity of solid target systems, which are available in only a few cyclotrons worldwide. In contrast, liquid targets, available in virtually in all cyclotrons, constitute a practical and reliable alternative. In this study, we discuss the production, purification, and radiolabeling of antibodies and nanobodies using copper-64 obtained

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12

Rinne, Sara S., Charles Dahlsson Leitao, Zahra Saleh-nihad, et al. "Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules." International Journal of Molecular Sciences 21, no. 6 (2020): 1972. http://dx.doi.org/10.3390/ijms21061972.

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HER3-binding affibody molecules are a promising format for visualization of HER3 expression. Cobalt-55, a positron-emitting isotope, with a half-life of 17.5 h, allows for next-day imaging. We investigated the influence of the charge of the radiocobalt–chelator complex on the biodistribution of anti-HER3 affibody molecule (HE)3-ZHER3 and compared the best radiocobalt-labeled variant with a recently optimized gallium-labeled variant. Affibody conjugates (HE)3-ZHER3-X (X = NOTA, NODAGA, DOTA, DOTAGA) were labeled with [57Co]Co (surrogate for 55Co). Affinity measurements, binding specificity and

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13

Luyten, Kaat, Tom Van Loy, Christopher Cawthorne, et al. "D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy." Pharmaceutics 13, no. 10 (2021): 1619. http://dx.doi.org/10.3390/pharmaceutics13101619.

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Positron emission tomography (PET) imaging of the C-X-C chemokine receptor 4 (CXCR4) with [68Ga]PentixaFor has intrinsic diagnostic value and is used to select patients for personalized CXCR4-targeted radionuclide therapy with its therapeutic radiopharmaceutical companion [177Lu]PentixaTher. However, a CXCR4-targeting radiopharmaceutical labeled with fluorine-18 is still of high value due to its favorable characteristics over gallium-68. Furthermore, clinical results with [177Lu]PentixaTher are promising, but there is still room for improvement regarding pharmacokinetics and dosimetry profile.

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14

Gaillard, Michel, Hussein Kanso, Franck Denat, Carole Calas-Blanchard, Nicolas Inguimbert, and Thierry Noguer. "Fe(III)-DOTA/Fe(III)-NOTA Complexes: Attractive Alternative Markers for Future Electrochemical Biosensors." Journal of The Electrochemical Society 167, no. 11 (2020): 117502. http://dx.doi.org/10.1149/1945-7111/ab9e80.

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15

Kiviniemi, Anu, Joonas Mäkelä, Jussi Mäkilä, et al. "Solid-Supported NOTA and DOTA Chelators Useful for the Synthesis of 3′-Radiometalated Oligonucleotides." Bioconjugate Chemistry 23, no. 9 (2012): 1981–88. http://dx.doi.org/10.1021/bc300253t.

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16

Desbois, Nicolas, Sandrine Pacquelet, Adrien Dubois, Clément Michelin, and Claude P. Gros. "Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition." Beilstein Journal of Organic Chemistry 11 (November 17, 2015): 2202–8. http://dx.doi.org/10.3762/bjoc.11.239.

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The Cu(I)-catalysed Huisgen cycloaddition, known as “click” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one “cold” metal (Cu, Ga, In) for future radionuclear imaging applications.

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17

Crespo, Óscar Vara, Jorge Turmo Arnal, and Ángel Rodríguez García-Brazales. "Las raíces intelectuales de la economía evolutiva." Revista de Historia Económica / Journal of Iberian and Latin American Economic History 23, no. 1 (2005): 177–86. http://dx.doi.org/10.1017/s021261090001185x.

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La economía evolutiva ha experimentado en los últimos años un notable auge en el ámbito científico europeo, desarrollando una amplia panoplia de modelos y teorías destinadas a estudiar diversos aspectos de los procesos económicos. Aunque la economía evolutiva se caracteriza como tal por utilizar los modelos poblacionales de la biología evolutiva, adopta elementos cruciales de las obras de Schumpeter y Simon, lo que dota a su trabajo de una gran originalidad y profundidad analítica. La presente nota tiene por objeto examinar la estructura y alcance de esta escuela de pensamiento a través de sus

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18

Amor-Coarasa, Alejandro, Monika Gruca, Sophie Hurez, Seza A. Gulec, Anthony McGoron, and John W. Babich. "Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators." Journal of Radioanalytical and Nuclear Chemistry 317, no. 3 (2018): 1485–90. http://dx.doi.org/10.1007/s10967-018-6011-1.

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19

Blom, Elisabeth, Irina Velikyan, Azita Monazzam, et al. "Synthesis and characterization of scVEGF-PEG-[68Ga]NOTA and scVEGF-PEG-[68Ga]DOTA PET tracers." Journal of Labelled Compounds and Radiopharmaceuticals 54, no. 11 (2011): 685–92. http://dx.doi.org/10.1002/jlcr.1909.

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20

Anderegg, Giorgio, Francoise Arnaud-Neu, Rita Delgado, Judith Felcman, and Konstantin Popov. "Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications* (IUPAC Technical Report)." Pure and Applied Chemistry 77, no. 8 (2005): 1445–95. http://dx.doi.org/10.1351/pac200577081445.

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Available experimental data on stability constants of proton (hydron) and metal complexes for seven complexones of particular biomedical and environmental interest: iminodiacetic acid [2,2'-azanediyldiacetic acid, IDA], (methylimino)diacetic acid [2,2'-(methylazanediyl)diacetic acid, MIDA]; 2,2',2'',2'''-{[(carboxymethyl)azanediyl]bis[(ethane-1,2-diyl)nitrilo]}tetraacetic acid (DTPA), 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid (TTHA); 2,2',2''-(1,4,7-triazonane-1,4,7-triyl)triacetic acid (NOTA); 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraac

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21

Kumar, Krishan, Michael Magerstädt, and Otto A. Gansow. "Lead(II) and bismuth(III) complexes of the polyazacycloalkane-N-acetic acids nota, dota, and teta." J. Chem. Soc., Chem. Commun., no. 3 (1989): 145–46. http://dx.doi.org/10.1039/c39890000145.

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22

Ray Banerjee, Sangeeta, Zhengping Chen, Mrudula Pullambhatla, et al. "Preclinical Comparative Study of 68Ga-Labeled DOTA, NOTA, and HBED-CC Chelated Radiotracers for Targeting PSMA." Bioconjugate Chemistry 27, no. 6 (2016): 1447–55. http://dx.doi.org/10.1021/acs.bioconjchem.5b00679.

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23

Hoareau, Raphaël, and Peter J. H. Scott. "Synthesis of perfluorinated analogs of DOTA and NOTA: bifunctional chelating groups with potential applications in hybrid molecular imaging." Tetrahedron Letters 54, no. 42 (2013): 5755–57. http://dx.doi.org/10.1016/j.tetlet.2013.08.035.

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24

Riondato, M., S. Pastorino, V. Duce, E. Giovannini, and A. Ciarmiello. "Comparative radium-223 labeling with NOTA and DOTA-somatostatin derivatives for a potential use in targeted cancer therapy." Nuclear Medicine and Biology 72-73 (July 2019): S50—S51. http://dx.doi.org/10.1016/s0969-8051(19)30328-2.

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25

Zhang, Yin, Hao Hong, Jonathan W. Engle, et al. "Positron Emission Tomography Imaging of CD105 Expression with a 64Cu-Labeled Monoclonal Antibody: NOTA Is Superior to DOTA." PLoS ONE 6, no. 12 (2011): e28005. http://dx.doi.org/10.1371/journal.pone.0028005.

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26

Botoso, Altamir. "A FOCALIZAÇÃO, O GÓTICO E O FANTÁSTICO EM A OUTRA VOLTA DO PARAFUSO, DE HENRY JAMES." Revista Guará - Revista de Linguagem e Literatura 10, no. 2 (2021): 88. http://dx.doi.org/10.18224/gua.v10i2.8840.

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O propósito deste artigo é realizar uma análise do romance A outra volta do parafuso, do escritor norte-americano naturalizado britânico, Henry James, evidenciando alguns elementos de sua construção tais como a focalização e a presença de componentes oriundos do gótico e do fantástico, os quais permeiam o relato em primeira pessoa de uma preceptora, que vê ou imagina que existam fantasmas na mansão onde vai trabalhar. Como suporte teórico, são utilizados os estudos críticos de Bromwich (2011), Leite (2006), Lima (2017), Matos (2018), Parreira (2007), Piglia (2019), Santos (2011), Sylvestre (20

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27

Notni, Johannes, Karolin Pohle, and Hans-Jürgen Wester. "Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides: practical consequences for the future of gallium-68-PET." EJNMMI Research 2, no. 1 (2012): 28. http://dx.doi.org/10.1186/2191-219x-2-28.

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28

Lee, Jun-Young, Pyeong-Seok Choi, Seung-Dae Yang, and Jeong-Hoon Park. "TiO2 Decorated Low-Molecular Chitosan a Microsized Adsorbent for a 68Ge/68Ga Generator System." Molecules 26, no. 11 (2021): 3185. http://dx.doi.org/10.3390/molecules26113185.

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We report column material for a 68Ge/68Ga generator with acid resistance and excellent adsorption and desorption capacity of 68Ge and 68Ga, respectively. Despite being a core element of the 68Ge/68Ga generator system, research on this has been insufficient. Therefore, we synthesized a low molecular chitosan-based TiO2 (LC-TiO2) adsorbent via a physical trapping method as a durable 68Ge/68Ga generator column material. The adsorption/desorption studies exhibited a higher separation factor of 68Ge/68Ga in the concentration range of HCl examined (0.01 M to 1.0 M). The prepared LC-TiO2 adsorbent sh

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29

Hassan, Hishar, Nur Faqihah Omar Samri, Wan Hamirul Bahrin Wan Kamal, and Muhamad Faiz Othman. "In Vivo biodistribution analysis of [68Ga]Ga-NOTA-pamidronic acid and [68Ga]Ga-DOTA-pamidronic Acid: Insights into bone-targeting radiopharmaceuticals." Journal of Radiation Research and Applied Sciences 18, no. 2 (2025): 101533. https://doi.org/10.1016/j.jrras.2025.101533.

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30

Roosenburg, S., P. Laverman, L. Joosten, et al. "PET and SPECT Imaging of a Radiolabeled Minigastrin Analogue Conjugated with DOTA, NOTA, and NODAGA and Labeled with 64Cu, 68Ga, and 111In." Molecular Pharmaceutics 11, no. 11 (2014): 3930–37. http://dx.doi.org/10.1021/mp500283k.

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31

Miranda, Ana Claudia Camargo, Caiubi Rodrigues de Paula Santos, Leonardo Lima Fuscaldi, et al. "68GA-NOTA-UBI AND 68GA-DOTA-UBI AS RADIOPHARMACEUTICALS FOR THE DIAGNOSIS OF INFECTIOUS PROCESSES: PRECLINICAL STUDIES AND TRANSLATION TO CLINICAL APPLICATION." Hematology, Transfusion and Cell Therapy 46 (April 2024): S2—S3. http://dx.doi.org/10.1016/j.htct.2024.04.052.

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32

Xie, Qing, Teli Liu, Jing Ding, et al. "Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE." European Journal of Nuclear Medicine and Molecular Imaging 48, no. 10 (2021): 3129–40. http://dx.doi.org/10.1007/s00259-021-05249-8.

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33

Wienhoff, B. E., A. F. Prasanphanich, S. R. Lane та ін. "Synthesis and Selective Radiolabeling Strategies for Production of [90Y-DOTA-βala-K-64Cu-NOTA-BBN(7–14) NH2] Conjugate; A Dual Negatron/Positron Emitting Radioligand". Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 43, № 2 (2012): 178–84. http://dx.doi.org/10.1080/15533174.2012.731120.

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34

Malmberg, Jennie, Anna Perols, Zohreh Varasteh, et al. "Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts." European Journal of Nuclear Medicine and Molecular Imaging 39, no. 3 (2011): 481–92. http://dx.doi.org/10.1007/s00259-011-1992-9.

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35

Navarro, Anne-Sophie, Thomas Le Bihan, Patricia Le Saëc, et al. "TE1PA as Innovating Chelator for 64Cu Immuno-TEP Imaging: A Comparative in Vivo Study with DOTA/NOTA by Conjugation on 9E7.4 mAb in a Syngeneic Multiple Myeloma Model." Bioconjugate Chemistry 30, no. 9 (2019): 2393–403. http://dx.doi.org/10.1021/acs.bioconjchem.9b00510.

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36

Cho, Yeonje, Armin Mirzapour-Kouhdasht, Hyosuk Yun, Jeong Hoon Park, Hye Jung Min, and Chul Won Lee. "Development of Cobalt-Binding Peptide Chelate from Human Serum Albumin: Cobalt-Binding Properties and Stability." International Journal of Molecular Sciences 23, no. 2 (2022): 719. http://dx.doi.org/10.3390/ijms23020719.

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Radioactive isotopes are used as drugs or contrast agents in the medical field after being conjugated with chelates such as DOTA, NOTA, DTPA, TETA, CyDTA, TRITA, and DPDP. The N-terminal sequence of human serum albumin (HSA) is known as a metal binding site, such as for Co2+, Cu2+, and Ni2+. For this study, we designed and synthesized wAlb12 peptide from the N-terminal region of HSA, which can bind to cobalt, to develop a peptide-based chelate. The wAlb12 with a random coil structure tightly binds to the Co(II) ion. Moreover, the binding property of wAlb12 toward Co(II) was confirmed using var

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37

Pattison, David A., and Rodney J. Hicks. "Molecular imaging in the investigation of hypoglycaemic syndromes and their management." Endocrine-Related Cancer 24, no. 6 (2017): R203—R221. http://dx.doi.org/10.1530/erc-17-0005.

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There has been recent progress in molecular imaging using a variety of cellular targets for the investigation of adult non-diabetic hypoglycaemic syndromes and its integration into patient management. These targets include peptide receptors (somatostatin receptors (SSTRs) and glucagon-like peptide-1 receptor (GLP-1R)) the amine precursor uptake and decarboxylation system utilising the diphydroxyphenylaline (DOPA) analogue 6-[18F]-l-fluoro-l-3,4-dihydroxyphenylalanine (18F-FDOPA), and glycolytic metabolism with 2-[18F]fluoro-2-deoxy-d-glucose (FDG). Accurate preoperative localisation and stagin

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38

Guleria, Mohini, Tapas Das, Jeyachitra Amirdhanayagam, Haladhar D. Sarma, and Ashutosh Dash. "Comparative Evaluation of Using NOTA and DOTA Derivatives as Bifunctional Chelating Agents in the Preparation of 68Ga-Labeled Porphyrin: Impact on Pharmacokinetics and Tumor Uptake in a Mouse Model." Cancer Biotherapy and Radiopharmaceuticals 33, no. 1 (2018): 8–16. http://dx.doi.org/10.1089/cbr.2017.2337.

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39

Ansari, Mohammad H., Mashood Ahmada, and Karel A. Dicke. "Synthesis of 2-(p-aminobenzyl) derivatives of 1,4,7-triazacyclononane-N,N′,N″-triacetic acid (NOTA) and 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″′-tetraacetic acid (DOTA): macrocyclic bifunctional chelating agents useful for antibodies labeling." Bioorganic & Medicinal Chemistry Letters 3, no. 6 (1993): 1067–70. http://dx.doi.org/10.1016/s0960-894x(00)80288-7.

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40

Cox, Jonathan P. L., Andrew S. Craig, Ian M. Helps, et al. "Synthesis of C- and N-functionalised derivatives of 1,4,7-triazacyclononane-1,4,7-triyltriacetic acid (NOTA), 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetrayltetra-acetic acid (DOTA), and diethylenenetriaminepenta-acetic acid (DTPA): bifunctional complexing agents for the derivatisation of antibodies." Journal of the Chemical Society, Perkin Transactions 1, no. 9 (1990): 2567. http://dx.doi.org/10.1039/p19900002567.

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41

IBRAHIM, FAISAL MAULANA, HOLIS ABDUL HOLIK, GHIFARI FARHAN HASIBUAN, and ACHMAD HUSSEIN SUNDAWA KARTAMIHARDJA. "MOLECULAR DOCKING AND ADMET PREDICTION OF 5-BENZYLOXYTRYPTOPHAN AS A POTENTIAL RADIOPHARMACEUTICAL KIT FOR MOLECULAR IMAGING OF CANCER." International Journal of Applied Pharmaceutics, December 11, 2021, 171–75. http://dx.doi.org/10.22159/ijap.2021.v13s4.43853.

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Objective: This in silico study aims to determine the inhibition effect of 5-BOTP with various bifunctional chelating agents (BFCA); NOTA, DOTA, TETA, CTPA, H2CB-DO2A, H2CBTE2A against the antiporter site of the LAT1. Methods: The research method consisted of the binding mode of 5-BOTP and its derivatives with LAT1, the docking score, the analysis of preADMET, and the overview of Ro5 compatibility. Results: The results showed that 5-BOTP-NOTA and 5-BOTP-DOTA had interactions with the gating residue (Phe252, Trp257, Asn258, and Tyr259) on the antiporter site of LAT1. 5-BOTP-NOTA and

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Pati, Bibekananda, Anuj Kumar, Arnab Chowdhury, et al. "An upgraded solid‐phase assembly of chelators (DOTA and NOTA) enabled bacterial uptake studies of radiolabeled peptide." ChemBioChem, December 10, 2024. https://doi.org/10.1002/cbic.202400996.

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Among popular radio metal chelators, DOTA and NOTA have been remarkably considered in radionuclide therapy and imaging studies due to several advantages in pharmacology. Here, we developed a practical and general method for assembling DOTA and NOTA in the solid phase peptide (pseudo‐dilute conditions) with a wide range of solvents using easily accessible and economical feedstocks, which mitigated unprecedented challenges faced by previously reported methods. This upgraded approach enabled an efficient installation of these two chelators on various bioactive peptide sequences. Finally, we asses

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Xie, Qing, Wenyuan Zhou, Xiangxi Meng, et al. "Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2." Neuroendocrinology, November 4, 2023. http://dx.doi.org/10.1159/000535037.

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Introduction: Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes, and to analyze the correlation between the image and pathology parameters. Method: Tumor bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the same mouse with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11 and [18F]AlF-NOTA-JR11 at 20, 60 and 120 min. The image parameters were obtained, including the maximum standard uptake value (SUVmax), mean

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Vorobyeva, Anzhelika, Moeen-ud Din, Alexey Schulga, et al. "Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression." EJNMMI Radiopharmacy and Chemistry 10, no. 1 (2025). https://doi.org/10.1186/s41181-025-00347-6.

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Abstract Background Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is overexpressed in several types of malignancies. Designed ankyrin repeat protein (DARPin) Ec1 is a 19 kDa engineered scaffold protein that binds with high affinity to EpCAM. Radiolabelled Ec1 might be used as a companion diagnostic for the selection of patients for personalized therapy. This study aimed to investigate the influence of different radiometal-chelator complexes on the biodistribution and imaging contrast of 68Ga-labelled Ec1. To investigate this, two macrocyclic chelators, 1,4,7-

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Fonseca, A. I., J. Sereno, S. Almeida, et al. "Unveiling the potential of copper-61 vs. gallium-68 for SSTR PET imaging." European Journal of Nuclear Medicine and Molecular Imaging, February 6, 2025. https://doi.org/10.1007/s00259-025-07116-2.

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Abstract Purpose In recent years, copper-61 has attracted considerable attention from both physicists and radiochemists due to its favorable physical decay properties for PET imaging and its ease of production at any cyclotron center producing [18F]FDG. The aim of this study was to evaluate the potential of 61Cu-based radiopharmaceuticals for PET imaging of NETs, as an alternative to the commonly used gallium-68. Methods Copper-61 was produced by irradiation of natural zinc liquid targets, followed by post-processing. In vitro evaluation of 61Cu- and 68Ga-labeled SST analogues was performed in

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Yang, Hua, Feng Gao, Brooke McNeil та ін. "Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide". EJNMMI Radiopharmacy and Chemistry 6, № 1 (2021). http://dx.doi.org/10.1186/s41181-020-00119-4.

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Abstract Background 64Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potential of this isotope, challenged by the presence of endogenous copper chelators. Pyridyl type chelators show good coordination ability with copper, prompting the present study of a series of chelates DOTA-xPy (x = 1–4) that sequentially substitute carboxyl moieties with pyridyl moieties on a DOTA backbone. Results We found that the presence of pyridyl groups significant

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HOLIK, HOLIS ABDUL, FAISAL MAULANA IBRAHIM, ABIB LATIFU FATAH, ARIFUDIN ACHMAD, and ACHMAD HUSSEIN SUNDAWA KARTAMIHARDJA. "IN SILICO STUDIES OF (S)-2-AMINO-4-(3,5-DICHLOROPHENYL) BUTANOIC ACID AGAINST LAT1 AS A RADIOTHERANOSTIC AGENT OF CANCER." International Journal of Applied Pharmaceutics, December 11, 2021, 239–43. http://dx.doi.org/10.22159/ijap.2021.v13s4.43868.

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Objective: This study aims to obtain a good activity of radiotheranostic kit for cancer which is built by combining (S)-2-amino-4-(3,5-dichlorophenyl) butanoic acid (ADPB) with various bifunctional chelators. Methods: This study was conducted through in silico method that consists of molecular docking simulation using AutoDock 4 as well as ADMET prediction using vNN-ADMET and Pre-ADMET. Six bifunctional chelators (i.e. CTPA, DOTA, H2CB-TE2A, H2CB-DO2A, NOTA, and TETA) were conjugated with ADPB as a carrier molecule and further analyzed through molecular docking and ADMET prediction.&#x0D

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Liu, Huanhuan, Xiaojun Zhang, Jingfeng Zhang, et al. "Comparison of 64Cu-DOTA-PSMA-3Q and 64Cu-NOTA-PSMA-3Q utilizing NOTA and DOTA as bifunctional chelators in prostate cancer: preclinical assessment and preliminary clinical PET/CT imaging." European Journal of Nuclear Medicine and Molecular Imaging, February 15, 2025. https://doi.org/10.1007/s00259-025-07131-3.

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Leupe, Hannes, Elin Pauwels, Timon Vandamme, et al. "Clinical impact of using [¹⁸F]AlF‐NOTA‐octreotide PET/CT instead of [⁶⁸Ga]Ga‐DOTA‐SSA PET/CT: Secondary endpoint analysis of a multicenter, prospective trial." Journal of Neuroendocrinology, June 4, 2024. http://dx.doi.org/10.1111/jne.13420.

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Abstract[18F]AlF‐NOTA‐octreotide ([18F]AlF‐OC) is a promising alternative for [68Ga]Ga‐DOTA‐somatostatin analogs (SSAs) in positron emission tomography (PET) imaging of the somatostatin receptor (SSTR). Our aim is to assess changes in TNM staging and differences in patient management between [18F]AlF‐OC PET/CT and [68Ga]Ga‐DOTA‐SSA PET/CT in the work‐up of neuroendocrine tumor (NET) patients. Patients who underwent both [18F]AlF‐OC and [68Ga]Ga‐DOTA‐TATE or [68Ga]Ga‐DOTA‐NOC PET/CT in our multicenter study (Pauwels et al., J Nucl Med.2023;63:632–638) with a NET were included for analysis. TNM

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Mitran, Bogdan, Helge Thisgaard, Sara Rinne, et al. "Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26." Scientific Reports 9, no. 1 (2019). http://dx.doi.org/10.1038/s41598-019-52914-y.

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AbstractGastrin-releasing peptide receptors (GRPRs) are promising targets in oligometastatic prostate cancer. We have recently used 55Co (T1/2 = 17.5 h) as a label for next day PET imaging of GRPR expression obtaining high imaging contrast. The radionuclide-chelator combination can significantly influence the biodistribution of radiopeptides. Therefore, in this study, we hypothesized that the properties of 55Co-labeled PEG2-RM26 can be improved by identifying the optimal macrocyclic chelator. All analogues (X-PEG2-RM26, X = NOTA,NODAGA,DOTA,DOTAGA) were successfully labeled with radiocobalt wi

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