Dissertations / Theses: 'Dotlak'

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Havel, Jiří. "Hodnocení porezity u tlakově litých odlitků z Al slitin." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230266.

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The aim of this diploma thesis is to analyse the porosity of die - cast cast that were made of the alloy AISi9u3 in iron-foundry Skoda Car Mlada Boleslav. The analysis and the sample comparisons are based on my own measurements and are also connected with previous diploma thesis which deals with that issue and was drawn up at Technical University in Brno. All measurements were statistically tested.

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Lefner, Jiří. "Hodnocení mechanických a strukturních vlastností nového bloku." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2009. http://www.nusl.cz/ntk/nusl-228721.

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The purpose of this dilploma thesis is to evaluate mechanical and structural properties of two types casts of Al-alloy (components of the engine block) which were made by different technologies. Die casting with local squeeze casting and without local squeeze casting. First of them is used in lot manufacture of the current engine block. The aim of the foundry is to change the technology and start to produce new block by the die casting without local squeeze casting. The samples were taken from the both parts (lower and upper part) of the current and the new engine block which are made in foundry of Skoda Auto a.c. in Mladá Boleslav. Sets of mechanical and structural properties were selected, evaluated and tested by statistical programs. It was used fifty casts of the engine blocks for the experiment.

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Khamzin, Yersin. "Technologie vstřikování zkušebních těles z termoplastů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444217.

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The diploma thesis focuses on the optimization of technological parameters of plastic injection molding and the study of the influence of technological parameters on the quality of molded test specimens’ type 1A. The quality of molded parts for 3 types of polypropylene (PP) with different melt flow rate (Mosten GB 002, Mosten GB 218, Mosten MA 230) and 1 type of polystyrene (PS) (Krasten PS GP 154) was evaluated in terms of dimensional stability and weight. The contribution of software for modeling the plastic injection molding process was evaluated in this work. SOLIDWORKS Plastics software was used to optimize technological parameters. The construction of the bodies, mold and cooling system was constructed, and test bodies were produced on the basis of parameters obtained from the simulation of the injection molding process. Their quality parameters were compared with a 3D model and for each of the studied materials the optimal technological parameters were selected in terms of quality and the degree of influence of individual injection parameters on the quality of moldings was evaluated. The accordance of the results of the theoretical simulation with the real experiment was proved and a computational module independent of the optimized quality parameters, generally suitable for optimizing the quality parameters of the injected parts, was developed.

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Lewis, W. Charles. "Selected ministry factors that may contribute to the interracial status of Dothan Community Church a case study /." Online full text .pdf document, available to Fuller patrons only, 2000. http://www.tren.com.

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Svenblad, Hampus, and Josefin Bengtsson. "Ideation through visualization : – The use of Storyboard as a preparing tool." Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-24270.

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Problem Ideation in group is used by many, often as a tool for creating new and innovative ways to solve problems and creating change. Groups may have difficulties to move from the phase of inspiration to the phase of ideation, if information and ideas aren’t defined in the team. The authors claim that this process can be helped by providing practical tools that are adapted and tested for the purpose. The reason is to foster concretization of volatile thoughts in form of inspiration and information. Purpose The study aims to investigate how Storyboard as a tool can be used to concretize thoughts and inspiration in a group before ideation. Method In order to collect empirical data the authors along with four other facilitators, conducted 24 DO TANK:s for the innovation contest Smart Lunch. The empirical data where then analyzed using theories related to the topic. To obtain further empirical information the authors conducted a open dialogue with the other facilitators. Conclusions The study shows that it’s possible to use Storyboard as a tool for specifying and collect a group’s thoughts before ideation. Furthermore the authors consider that the use of Storyboard enables a more efficient ideation as the groups becomes more focused when they’ve defined their thoughts. Problemformulering Idégenerering i grupp används idag av många, ofta som ett verktyg för att kunna skapa nya och innovativa sätt för att lösa problem och skapa förändring. Det finns svårigheter för grupper att gå från det som författarna kallar inspirationsfasen vidare till idégenereringsfasen, då information och tankar fortfarande inte är fastställda. Författarna menar att denna process går att underlätta genom att tillföra konkreta verktyg anpassade och testade för idéutvecklingsprocessernas olika faser. Anledningen är att främja konkretisering av flyktiga och svårtolkade tankar i form av inspiration och information. Syfte Studiens syfte är att undersöka hur verktyget Storyboard, tidigare använt inom filmindustrin kan användas som konkretiseringsverktyg inför en idégenerering i en gruppkonstellation? Metod För att samla in empirisk data har författarna, tillsammans med fyra andra facilitatorer, genomfört 24 st. DO TANK:s för innovationstävlingen Smart Lunch. Detta empiriska material har sedan analyserats med hjälp av teorier kopplade till ämnet. För att få ytterligare empirisk information har författarna utfört en öppen dialogintervju med facilitatorerna. Slutsatser Studien visar att det med fördel går att använda verktyget Storyboard för att konkretisera och samla en grupps tankar inför en idégenrering. Vidare anser författarna att detta möjliggör en effektivisering av idégenrereringsprocessen då denna blir mer fokuserad när gruppen är enig.

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Cockerham, Catherine L. "Burial practice at Tell Dothan was Tomb 1 a "byt mrzḥ"? /." Theological Research Exchange Network (TREN), 1995. http://www.tren.com.

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Bengtsson, Linda. "Spin-coatade dispersioner på glasytor : en studie av aggregationen mellan latex och DoTAB med AFM." Thesis, Karlstads universitet, Fakulteten för teknik- och naturvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-14568.

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Zhou, Chan Dante. "Reputación del streamer peruano de Dota 2: la perspectiva del jugador de Dota 2 peruano." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/654794.

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La industria gamer ha llevado a la posibilidad de subsistir económicamente del streaming. Dado que los streamers generan ingresos en relación con su audiencia, mientras mayor sea esta y esté más conectada con ella mayor probabilidad habrá de que genere mayores ingresos. Por ende, surge un nuevo modelo de negocio que requiere de una gestión reputacional para construir esta audiencia. Para ello, se necesita un primer análisis del contexto peruano desde la percepción que mantienen los jugadores de Dota 2 peruanos frente a los streamers peruanos de Dota 2. Por ello, este trabajo utiliza el paradigma naturalista/interpretativo que estudia al público en su contexto natural, es decir los gamers y el Dota 2. El diseño para este sería fenomenológico pues se busca entender la percepción (reputación) del streamer peruano desde el punto de vista de los jugadores de Dota 2 en general. Finalmente, se usa un enfoque cualitativo para obtener las opiniones de los usuarios que juegan Dota 2 sobre los streamers peruanos, con el uso de entrevistas semiestructuradas para alinearlas en los 3 aspectos para medir reputación: sólida dimensión axiológica, comportamiento comprometido y calidad de servicio. The gaming industry has led to the possibility of economically subsisting on streaming. Since streamers generate income in relation to their audience, the larger their audience and the more connected they are, the greater probability of generating more income will exist. Therefore, a new business model emerges that requires reputational management to build this audience. To do this, a first analysis of the Peruvian context is needed from the perception that Peruvian Dota 2 players maintain compared to Peruvian Dota 2 streamers. That’s why, this work uses the naturalistic paradigm /interpretive that studies the public in its natural context, that is, the gamers in their gameplay and the design for this would be phenomenological because it seeks to understand the perception (reputation) of the Peruvian streamer from the point of view of Dota 2 players in general. Finally, a qualitative approach is used to obtain the opinions of the users who play Dota 2 on the Peruvian streamers, with the use of semi-structured interviews to align them in the 3 aspects to measure reputation: solid axiological dimension, committed behavior and quality of service. Trabajo de investigación

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VARGAS, GARCIA ERNESTO 502720, and GARCIA ERNESTO VARGAS. "Dotar a la acción penal privada de un procedimiento que haga eficaz la impartición de justicia penal." Tesis de doctorado, Universidad Autónoma del Estado de México, 2016. http://hdl.handle.net/20.500.11799/58242.

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En el capítulo primero se desarrolló con apego al método histórico, el cual permitió conocer el trato que se le dio a la víctima u ofendido en el procedimiento penal, en el siglo V (procedimiento no jurisdiccional). La investigación utiliza el método analítico, con el cual se examina el papel de la víctima sancionando al infractor con la autorización de su comunidad, la cual legitimaba su actuar, debido a que la víctima era considerada parte central en el sistema de justicia penal, esta forma de impartir justicia es el antecedente de la acción penal privada, tema en estudio, por esta razón, se retrotrae la investigación a la etapa histórica, lo que justifica que la justicia en manos de la víctima no es una novedad, es el origen del derecho penal.

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Terp, Megan Cavanaugh. "Improved Nanoparticle Preparation and Delivery Technology for DOTAP and Oligonucleotide Based Lipoplexes." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338301430.

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Graves, S., H. Valdovinos, W. Cai, T. Barnhart, and R. Nickles. "Pursuit of purity: Measurement of chelation binding affinities for NOTA, DOTA, and desferal with applications to effective specific activity." Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-166419.

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Introduction The effective specific activity of a radioisotope is an indirect and highly useful way to describe a radioactive sample’s purity. A high effective specific activity combines the concept of an isotopically pure product with suitability via selectivity of a particular chelating body. The primary goals of this work are twofold: 1) To determine which metallic impurities have the largest impact on the effective specific activity for a given chelator, and 2) to form a model based on the binding affinities of each metal for to calculate a ‘theoretical effective specific activ-ity’ from broad band trace metal analysis. If successful, this information can be used to guide the production of high specific activity products through the systematic elimination of high-impact metallic impurities. Material and Methods Phosphor plate thin layer chromatography (TLC) was used to measure the effective specific activ-ity of 64Cu by NOTA and DOTA, and 89Zr by des-feral (DF). Typical measured effective specific activities are 2–5 Ci/μmol for 64Cu and 1–2 Ci/μmol for 89Zr. Samples were created containing increasing cod competitive burdens (X) of CuCl2, ZnCl2, FeCl2, NiCl2, CrCl3, CoCl2, MnCl2, and YCl3. Standard concentrations were measured by microwave plasma atomic emission spectrometry. 50 pmol of NOTA, DOTA, or DF were added following the activity aliquots of 64Cu or 89Zr. Labeling efficien-cies (64Cu-NOTA, 64Cu-DOTA, 89Zr-DF) were measured using TLC’s, and were fit by linear regression to the form f(X) = b/(1 − AX), where A is the chelation affinity (inverse of dissociation constant) and X is the molar ratio of the metallic impurity to the amount of chelator. Results and Conclusion Affinity of Zr for DF was assumed to be unity, while the affinities of Cu for NOTA and DOTA were explicitly measured and were found to be 0.93 ± 0.13 and 5.2 ± 3.2 respectively. It was found that Cu had the highest affinity for NOTA by a factor of 266, and that Zr had the highest affinity for DF by a factor of 40. • In order of decreasing affinity to NOTA: Cu, Zn, Fe, Co, Cr, Y, and Ni • In order of decreasing affinity to DOTA: Cu, Y, Zn, Co, Ni, Cr, and Fe • In order of decreasing affinity to DF: Zr, Y, Cu, Zn, Ni, Fe, Co, Cr These results suggest that aside from the carrier element it is most important to remove zinc from 64Cu products prior to chelation with NOTA and yttrium from 64Cu and 89Zr products prior to chelation with DOTA and DF, respectively. Therefore, it is logical to believe that 89Zr effective specific activities could be greatly improved by secondary separations with the goal of re-moving additional yttrium target material. Chelation affinities of NOTA, DOTA, and DF for several common metals have successfully been investigated. These values will guide our future attempts to provide high effective specific activity 64¬Cu and 89Zr. Furthermore, a preliminary model has been formed to calculate effective specific activity from the quantitative broad band analysis of trace metals. Future work will include chelator affinity measurements for other likely contaminants, such as scandium, titanium, zirconium, molybdenum, niobium, gold, gallium, and germanium. Details will be presented.

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Schroer, Christine. "In vitro-Untersuchungen zum Einsatz von DOTAP in der Gentherapie der Cystischen Fibrose /." [S.l. : s.n.], 1999. http://www.gbv.de/dms/bs/toc/303409436.pdf.

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Clinton, Jonathan. "Using Membership Categorisation Analysis to Study Identity Creation in the Digital game Dota2." Thesis, Södertörns högskola, Institutionen för kultur och lärande, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-28704.

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One aspect of the internet that has been discussed in relation to identity creation is whether we can transcend our physical selves when we enter an online environment, thus potentially creating the internet as a space where we could leave our bodies when performing our identity. The purpose of this master thesis is to investigate the accomplishment of membership categorization within the domain of online gaming and through it identity in an online gaming environment. This thesis argues that the discourse within Dota2 constructs the identity of the unsuccessful gamer as an outsider or deviant in terms of nationality, sexuality, and mental capability. Games of Dota2 have been observed and the interaction via the in game chat system has been transcribed and analyzed using Membership Categorization Analysis. The study found that membership was not commonly assigned but when it was, it was associated with the incumbent being on one’s own team and performing lower than expected. Also, in the cases where categories were assigned to players, these were assigned to unsuccessful players (This interactive feature is supported previous research by Eklund (2011) and Linderoth & Olsson (2010) in that they created the game as male centric western European space. The expectations of a successful player were not accomplished in order to inform the identity creation process of successful gamers. The results suggest that identity in Dota2 is structured around a players displayed skill and that the identity created is often based on stereotypes associated with certain nationalities, genders and mental capabilities. The use of MCA offered a holistic approach to how identities were created in online gaming that allowed the researcher to approach the subject without any preconceptions as to what would be found. The study also showed that the use of MCA may be useful when it comes to identity creation within virtual worlds.

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Silva, Ana Claudia Machado. "Cinética e dosimetria do [177Lu-DOTA0, Tyr3]octreotato em pacientes com tumores carcinoides." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-29102014-130657/.

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Tumores carcinoides (neoplasias bem diferenciadas) são tumores neuroendócrinos que podem surgir em diferentes locais anatômicos. Na população a prevalência dos tumores carcinoides é de aproximadamente 10 casos para um milhão de habitantes e sua incidência é maior na quinta e sexta década de vida. Este trabalho propõe um modelo cinético baseado na teoria da análise compartimental em humanos com tumores carcinoides que se submeterão ao tratamento com o radiofármaco [177Lu-DOTA0,Tyr3]Octreotato. Imagens cintilográficas dinâmicas planares, obtidas imediatamente à injeção de 370 MBq (10 mCi) do radiofármaco, foram obtidas com o tomógrafo SPECT (Single Photon Emission Computed Tomography). Por meio da seleção de regiões de interesse (ROI) os resultados foram digitalizados e aplicados ao modelo cinético aqui proposto. A primeira fase do estudo (atividade de 370 MBq) teve como objetivo conhecer os parâmetros cinéticos e subsequentemente, o paciente foi submetido ao protocolo de tratamento radioterápico, a critério médico, aos quatro ciclos de 7,4 GBq (200 mCi) do radiofármaco. Desta forma, foi possível estimar previamente as constantes cinéticas ki,j da biodistribuição do 177Lu-DOTATATO no corpo, sendo ki,j a fração de transferência do i-ésimo compartimento (tecido ou órgão) para o j-ésimo compartimento a partir das ROI demarcadoras dos órgãos de maior captação, a saber: fígado, rins, região vascularizada e tumores carcinoides. A partir das constantes cinéticas ki,j a estimativa de dose absorvida em 26 órgãos foi estimada pelo método MIRD. Os resultados dosimétricos foram compatíveis com outras metodologias descritas na literatura. Para um paciente adulto de 73,6 kg, em termos médios seus rins (sem os protetores renais) recebem a maior intensidade de dose (2,39 mGy/MBq) seguido do fígado (0,70 mGy/MBq). Observou-se que tumores com aproximadamente 100g recebem dose da ordem de 0,52 mGy/MBq independentemente da posição a que se encontram no corpo. Este achado se deve à predominância do dano devido às partículas beta quando comparado à radiação gama que possui pouco rendimento de emissão no processo de decaimento do 177Lu. Portanto, os parâmetros cinéticos que promovem a captação do 177Lu nas células são os principais responsáveis pela composição da dose no tumor e demais órgãos. Carcinoid tumors (well differentiated neoplasms) are neuroendocrine tumors that may arise in different anatomical locations. The population prevalence of carcinoid tumors is approximately 10 cases per one million inhabitants. Its incidence is higher in the fifth and sixth decade of life. This paper proposes a kinetic model in humans with carcinoid tumors who will underwent treatment with the radiopharmaceutical [177Lu-DOTA0,Tyr3 ]OCTREOTATE based on the theory of compartmental analysis. Dynamic planar scintigraphic images acquired immediately upon injection of 370 MBq (10 mCi) of the radiopharmaceutical were obtained with the SPECT (Single Photon Emission Computed Tomography) tomography. Samples from regions of interest (ROI) were used for the kinetic study applying the kinetic proposed model. The first phase of the study (activity 370 MBq) was aimed to evaluate the kinetic parameters. Subsequently, the patient underwent the [177Lu-DOTA0,Tyr3 ]OCTREOTATE radiotherapy protocol, under the physician\'s prescription (up to four cycles of 7.4 GBq (200 mCi)). Thus, it was possible to previously estimate the kinetic constants ki,j relative to biodistribution of [177Lu-DOTA0,Tyr3 ]OCTREOTATE in the body. The ki,j is the transfer fraction from the ith compartment (a tissue or an organ) to the jth compartment. Only few organs showed significant ROI radioactivity count level, among them: the liver, kidney, blood and carcinoid tumors. The MIRD method and the kinetic constants ki,j were used to estimate the absorbed dose in 26 body organs. The absorbed dose D(mGy/MBq) was comparable to other methods described in the literature. For an adult patient of 73.6 kg, on average, the kidneys (without amino acid protectors) showed the highest dose (2.39 mGy/MBq) followed by liver (0.70 mGy / MBq) and tumor (0.52 mGy/MBq) with a tissue size of approximately 100 g. It was observed that tumors receive the same absorbed dose D(mGy/MBq) regardless their position in the body. This finding is due to the predominance of the tissue radiation damage of beta particles compared to gamma radiation that has little yield emission in the 177Lu decay scheme. Therefore, the kinetic parameters ki,j that promote the uptake of 177Lu in cells are primarily responsible for the absorbed D dose in the tumor and other organs.

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Ollier, Sylvie. "Régime dotal et pratiques communautaires d'après les notaires de Draguignan (1655 à 1715)." Nice, 1997. http://www.theses.fr/1997NICE0041.

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Le droit matrimonial provençal sera dominé pendant tout l'ancien régime par des règles de droit romain. Le régime dotal sera ainsi appliqué avec une certaine rigueur dans toute la Provence et plus particulièrement dans le var. Toutefois, les contrats de mariages contenus dans les registres notariés de Draguignan entre 1655 et 1715, tendraient a démontrer un certain affaiblissement du caractère séparatiste du régime dotal. Les époux étant avant tout soucieux d'assurer les droits du conjoint survivant dans une Provence en crise. De plus, le régime dotal est le plus souvent absorbe dans une communauté familiale. La vie en communauté était encore très fréquenté en Provence au XVIIe siècle. Elle suppose la vie en commun sous le même toit de plusieurs couples. Elle constitue avant tout un système d'assistance des plus faibles et permet de maintenir l'intégrité du patrimoine foncier.

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Johansson, Filip, and Jesper Wikström. "Result Prediction by Mining Replays in Dota 2." Thesis, Blekinge Tekniska Högskola, Institutionen för datalogi och datorsystemteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2288.

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Context: Real-time games like Dota 2 lack the extensive mathematical modeling of turn-based games that can be used to make objective statements about how to best play them. Understanding a real-time computer game through the same kind of modeling as a turn-based game is practically impossible. Objectives: In this thesis an attempt was made to create a model using machine learning that can predict the winning team of a Dota 2 game given partial data collected as the game progressed. A couple of different classifiers were tested, out of these Random Forest was chosen to be studied more in depth. Methods: A method was devised for retrieving Dota 2 replays and parsing them into a format that can be used to train classifier models. An experiment was conducted comparing the accuracy of several machine learning algorithms with the Random Forest algorithm on predicting the outcome of Dota 2 games. A further experiment comparing the average accuracy of 25 Random Forest models using different settings for the number of trees and attributes was conducted. Results: Random Forest had the highest accuracy of the different algorithms with the best parameter setting having an average of 88.83% accuracy, with a 82.23% accuracy at the five minute point. Conclusions: Given the results, it was concluded that partial game-state data can be used to accurately predict the results of an ongoing game of Dota 2 in real-time with the application of machine learning techniques.

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Pessoa, Victor Felipe Barbosa. "Videogames e comunicação: dinâmicas de comunicação no Dota 2." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/6218.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-09-16T11:24:00Z No. of bitstreams: 2 Dissertação - Victor Felipe Barbosa Pessoa - 2016.pdf: 4794886 bytes, checksum: d1dc624e04b07c27cd9d7bf53df90955 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-09-16T11:24:33Z (GMT) No. of bitstreams: 2 Dissertação - Victor Felipe Barbosa Pessoa - 2016.pdf: 4794886 bytes, checksum: d1dc624e04b07c27cd9d7bf53df90955 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2016-09-16T11:24:33Z (GMT). No. of bitstreams: 2 Dissertação - Victor Felipe Barbosa Pessoa - 2016.pdf: 4794886 bytes, checksum: d1dc624e04b07c27cd9d7bf53df90955 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-08-09 This research places itself as a study of video game media, through the game Dota 2, working on the rapprochement between game studies and communication studies. This work starts from the ideia that the study of media consolidates itself in the study of the transformations, new speed and deployment that the media imply to the life of the individuals, stipulating new ways of interaction and communication. Here we aim to explore which characteristics of video game media contributes and assists on the construction of communication dynamics through the community of the game. The work is divided in three moments, on the first we gather some concepts and ideas already discussed about communication, media, video games and communities; next we go to the description of the object of analysis, the game Dota 2, dissecting it in order to expose all its workable resources and characteristics; lastly, we go to the analysis of those elements utilizing the biases, concepts and methods gathered, with the intention that the discussion provides information about the paths and actions that the media has that stipulates the such dynamics. Este trabalho se coloca como um estudo da mídia do videogame, através do game Dota 2, trabalhando na aproximação dos estudos sobre jogos e games com os estudos em comunicação. O trabalho parte da ideia de que o estudo das mídias se consolida no estudo das transformações, velocidades e desdobramentos que as mídias implicam à vida dos indivíduos, estipulando novas formas de interação e comunicação. Aqui, procura-se explorar quais características da mídia do videogame contribuem e auxiliam na construção de dinâmicas comunicacionais junto à comunidade do game. O trabalho é dividido em três momentos, onde primeiro se levantam os conceitos e ideias discutidos sobre comunicação, mídia, videogame e comunidade; em seguida parte-se para uma descrição do objeto de análise, o game Dota 2, dissecando-o com o intuito de expor todos seus recursos e características trabalháveis; por fim, parte-se para a análise de tais elementos se utilizando dos vieses, conceitos e metodologias levantados, com o intuito de que as discussões apresentadas forneçam informações sobre os caminhos e ações que a mídia possui para estipular tais dinâmicas.

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Brennecke, Benjamin Jakob [Verfasser]. "Enzyme-Responsive DOTA-Based Optical Probes / Benjamin Jakob Brennecke." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1237685869/34.

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Lindqvist, Kalle, and Dennis Nilsson. "Developing a 5v5 Framework for DotA 2 Bot Competition." Thesis, Malmö universitet, Fakulteten för teknik och samhälle (TS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20773.

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Multiplayer online battle arena (MOBA) games have properties that make them suitable for research in artificial and computational intelligence. MOBA games are generally played team vs team meaning planning and organizing the team is one of the most important aspects. This makes it suitable for research in artificial intelligence agent cooperation. This paper presents a literature review performed in the area of artificial and computational intelligence regarding MOBA games. The findings are that there is little or no research made in the area. The research found concerning MOBA games is in the context of player behaviour and toxic behaviour in the MOBA game league of legends. What is found is encouragement on developing frameworks supporting 5v5 matches in MOBA games which this paper also presents, a 5v5 framework for bot-matchmaking in DotA 2 making it possible for users to develop bots to be run versus the in-game AI.

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Andersson, Martin. "Phase Phenomena in Polymer Networks : Empirical Studies on the Influence of Hydrophobicity, Charge Density and Crosslinks on Macroion-Induced Phase Transitions in Polyelectrolyte Gels." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-145381.

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The thesis concerns polyelectrolyte gels in contact with oppositely charged proteins and surfactant micelles, and includes of four papers (I-IV). In paper I confocal Raman spectroscopy was introduced as a method to trace micelles and investigate the structure of gel-surfactant complexes, in phase separated gel spheres. In paper II, the binding of surfactants to microspheres (~50-100 µm) was investigated by means of a micromanipulator-assisted microscopy method. The two surfactants were found to display qualitative difference respect to degree of swelling, surfactant distribution in the gels, and the difference is discussed in terms of absence/presence of hydrophobic attraction to the polyelectrolyte gel network. Kinetics of volume change in gels were analyzed. Aggregation numbers of micelles in polystyrenesulfonate (PSS) solutions, obtained from fluorescence quenching measurements, are presented. In paper III, phase behaviour, protein assembly and diffusion, was studied in PSS gel microspheres. Interpretation of results was aided by measurements of osmotic swelling of individual gel networks, and by combining the results with studies of protein diffusion in macroscopic (cm-sized) gel spheres. Complexes formed were further analyzed with small angle x-ray spectroscopy. In paper IV phase behaviour of mixed ionic/nonionic surfactant micelles is investigated in cm-sized gel spheres. The coexistence of three phases, the formation of dense shells in the bulk of the gels and other phenomena are described for the first time, and the results are presented along with discussion on the charge-density of spherical micelles and of network induced hysteresis effects in gels. The composition and microstructure of phases are investigated by confocal Raman spectroscopy and small-angle x-ray scattering respectively. The results are interpreted with aid of highly detailed theoretical model calculations.

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21

Audras, Matthieu. "Caractérisation structurale de complexes d'actinides (III) et (IV) par le ligand DOTA." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20096/document.

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Les anions polyaminocarboxylates ont été identifiés comme des composés d'intérêt pour les opérations de séparation des actinides, dans la migration des actinides dans l'environnement et dans la radiotoxicologie humaine. La caractérisation structurale de complexes formés entre les actinides et les ligands polyaminocarboxylates est essentielle pour une meilleure compréhension des interactions actinides – ligands. Parmi les anions polyaminocarboxylates, le macrocycle DOTA (acide 1,4,7,10-tétraazacyclododécane-tétraacétique) est décrit comme un agent complexant très fort des lanthanides(III), mais a été très peu étudié avec des actinides. L'objectif de ce travail de thèse est de décrire les complexes formés entre les actinides (III) et (IV) et le ligand DOTA et de les comparer avec les complexes de lanthanides(III). Pour cela, une approche a été mise en place afin de caractériser les complexes par des techniques analytiques complémentaires (spectrophotométrie, spectrométrie de masse à ionisation par électrospray, RMN, EXAFS, électrochimie) mais également par des calculs de chimie théorique pour aider à l'interprétation des données expérimentales.La formation d'un complexe de stœchiométrie 1:1 est observée avec les actinides(III) (américium et plutonium) comme dans le cas des lanthanides(III) : il y a formation rapide d'espèces intermédiaires qui évoluent lentement vers la formation d'un complexe limite. Au sein de ce complexe, le cation se trouve à l'intérieur de la cavité formée par le macrocycle DOTA, comme dans le cas des lanthanides(III). Quatre atomes d'azote et atomes d'oxygène des fonctions carboxylates sont impliqués dans la sphère de coordination du cation. Néanmoins, des différences sont observées sur les longueurs de liaisons formées entre le cation et les atomes d'azote (les liaison sont légèrement plus courtes dans le cas des complexes d'actinides) ainsi que sur la cinétique de complexation qui est légèrement plus rapide pour les actinides(III) que pour les lanthanides(III) de rayon ionique équivalent. Le même comportement en solution est observé lors de la complexation des actinides(IV) (uranium, neptunium et plutonium) à l'exception du thorium : il y a formation lente d'un complexe de stœchiométrie 1:1 (actinides(IV):ligand) dans lequel le cation se trouve à l'intérieur de la cavité formée par le ligand, bien que la cinétique de complexation des actinides (IV) soit plus lente que celle des actinides(III). L'étude des complexes thorium(IV)-DOTA montre la présence de complexes de stœchiométrie 1:1 et 1:2 en solution, pour lesquels seules les fonctions carboxylate du ligand seraient impliquées dans la complexation.Enfin, une première estimation de la constante de stabilité des complexes plutonium(IV)-DOTA, effectuée par des mesures électrochimiques, indique que les complexes d'actinides(IV) sont environ 10 ordres de grandeurs plus stables que les complexes d'actinides(III), comme ce qui a pu être observé avec d'autres polyaminocarboxylates The polyaminocarboxylate anions have been identified as compounds of interest in the operations of actinide separation, in actinide migration in the environment and in human radiotoxicology. The structural characterization of complexes formed between actinides and polyaminocarboxylates ligands is essential for a better understanding of actinide-ligands interactions. Among the polyaminocarboxylate anions, the DOTA ligand (1,4,7,10-tetraazacyclododecane tetraacetic acid) is described as a very strong complexing agent of the lanthanides(III), but has been little studied with actinides. The objective of this thesis is to describe the complexes formed between the actinides (III) and (IV) and the DOTA ligand, and compare them with the lanthanide complexes. For this, an approach has been introduced to characterize the complex by complementary analytical techniques (spectrophotometry, electrospray ionization mass spectrometry, NMR, EXAFS, electrochemistry), but also by calculations of theoretical chemistry to help the interpretation of the experimental data. The formation of a 1:1 complex is observed with the actinides(III) (plutonium and americium) as in the case of lanthanides(III): rapid formation of intermediate species which evolves slowly towards the formation of a limit complex. Within this complex, the cation is located inside the cavity formed by the ligand. Four nitrogen atoms and oxygen atoms from the carboxylate functions are involved in the coordination sphere of the cation. However, differences were observed in the bond lengths formed between the cation and the nitrogen atoms (the bonds are somewhat shorter in the case of actinide complexes) as well as the complexation kinetics, which is slightly faster for the actinides(III) than for lanthanide(III) ions of equivalent radius. The same behavior was observed in solution upon complexation of actinides(IV) (uranium, plutonium and neptunium): slow formation of a 1:1 complex (actinide(IV):ligand) in wherein the cation is located inside the cavity formed by the macrocycle DOTA, although the kinetics of actinide(IV) complexation is slower than for the actinides(III) complexation. Nevertheless, the study of thorium(IV)-DOTA complexes shows differences since 1:1 and 1:2 complexes in solution are detected, and where only the carboxylate functions are involved in the coordination sphere of the cation. Finally, an initial estimate of the stability constant of the plutonium(IV)-DOTA complexes by electrochemical measurements indicates that complexes of actinide(IV) are approximately 10 orders of magnitude more stable than the complex of actinides(III), as previously observed with other polyaminocarboxylate anions

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22

Exler, Michal. "Lokalizace stanic v Internetu pomocí systému King." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2011. http://www.nusl.cz/ntk/nusl-218842.

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This thesis is focus on problematics of nodes localization in Internet. There are describe methods for prediction latency by using artificial coordinates systems and by using direct measurement. This thesis is primarily focus on method names King, which is estimates latency between arbitrary end hosts by using recursive DNS queries in system for translate domain name.

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23

Barboříková, Hana. "Směsné lipidy a jejich interakce s biopolymery." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316157.

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This thesis focuses on the study of interactions between hyaluronan and lipid DOTAP and its mixtures with DPPC in water. First, the aggregation behavior of the lipid itself and its mixtures was measured, afterwards the influence of hyaluronan in different concentration was studied. Further the fluorescence anisotropy of fluorescence probe DPH in these mixtures and influence of cholesterol was measured. These properties were investigated by fluorescence spectoscopy using pyrene and DPH as fluorescence probes. The measurements revealed that the addition of hyaluronan has observable influence on the aggregation behavior of the lipid DOTAP and its mixtures with DPPC and that cholesterol influences liposomes fluidity.

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24

Kriemen, Ella [Verfasser]. "Synthese modularer DOTA-Derivate für die zielgerichtete Tumordiagnostik / Ella Kriemen." München : Verlag Dr. Hut, 2015. http://d-nb.info/1079768211/34.

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25

Hanna, Jill. "Applications of DOTA-Lanthanide "Click" complexes to sensing and imaging." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/8743.

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While copper is an essential micronutrient in all living organisms, copper misregulation in humans is associated with neurodegenerative disorders such as Menkes and Wilson’s diseases, amyotrophic lateral sclerosis and Alzheimer’s disease. Furthermore, copper is a widely-produced pollutant and thus the detection of Cu(II) and Cu(I) has received much attention in recent years. Copper can be detected in a number of ways including; quenching of fluorescence upon the binding of paramagnetic Cu(II) (a "turn-off" response); augmentation of fluorescence upon Cu(II) binding due to PET modulation (a "turn-on" response); and selective Cu(II)- or Cu(I)-catalysed reactions where the luminescence of the product is distinctly different to that of the starting material. A review of Cu(I) and Cu(II) sensors is described herein. The Hulme group has previously developed a sensor for ligand-bound copper(I) utilising the copper(I)-catalysed [GS-−Cu(I)] variant of the Huisgen 1,3-dipolar cycloaddition reaction. Cu(I)-catalysed alkyne-azide cycloaddition (CuAAC or “click”) was carried out between an alkynyl Eu(III)-DOTA complex and a dansyl azide yielding a 1,4-triazole with a modest turn-on response (10-fold increase in luminescence). The project described herein aimed to achieve a more significant increase in lanthanide luminescence intensity through alteration of the donor moeity, lanthanide ion, and linker length between donor and acceptor moiety. The synthesis of several lanthanide-DOTA complexes, azido fluorophores and the formation of novel Cu(I)-sensors via CuAAC is described herein. All Cu(I) sensors were excited at their individual λex and their lanthanide luminescence intensity was measured using a timedelayed phosphorimeter. The DOTA structural motif has the ability to complex a plethora of potentially useful radionuclides including; yttrium, indium, gallium, lutetium and gadolinium. In general, DOTA-complexes doped with gadolinium are utilised for the identification of tumour sites while yttrium or indium complexes are used for tumour treatment. Biotin-DOTA conjugates have previously been used for pretargeted cancer imaging and radiotherapy. Biotinidase degradation of the amide bond in some biotin constructs has been reported, rendering them unable to bind to the pre-targeted antibody-(strept)avidin site. A novel biotinyl azide lacking this vulnerable amide bond is reported, with potential for bioconjugation to a variety of biomolecules via “click” chemistry. The synthesis of two novel biotinylated Gd-DOTA complexes, with prospective application as pretargeted MRI contrast agents, are also described.

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Illy, Marie-Claire. "Etude du comportement paramagnétique des actinides en solution avec des ligands polyaminocarboxylates cycliques." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTS140/document.

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« Etude du comportement paramagnétique des actinides en solution avec des ligands polyaminocarboxylates cycliques »Le comportement paramagnétique des cations actinide (éléments 5f) peut être étudié via la spectroscopie RMN liquide en suivant deux axes de recherche complémentaires : les susceptibilités magnétiques et les déplacements chimiques.Dans un premier temps, lorsque les interactions entre le cation actinide et le ligand sont négligeables, la susceptibilité magnétique molaire est accessible par la méthode d’Evans. Cette méthode est applicable pour des échantillons en solution autour de la température ambiante. Elle a été confrontée à la mesure SQUID sur échantillon solide à très basses températures pour le complexe [NpO2(DPC)2Li2]. Les deux méthodes ont donné des susceptibilités magnétiques molaires du même ordre de grandeur même si ce composé n’est pas optimal pour la comparaison.La méthode d’Evans a été utilisée pour compléter les données expérimentales de la littérature. La mesure de la susceptibilité magnétique du cation PuVO2+ (5f3) en milieu non complexant a été mesurée au laboratoire. Les calculs de susceptibilités magnétiques molaires réalisés par la méthode SO-CASPT2 pour les cations actinide aux degrés d’oxydation (+IV), (+V) et (+VI) (AnIV = UIV, NpIV, PuIV et AnV/VI = NpV/VI, PuV/VI) en milieux non complexant puis complexants chlorure et nitrate ont été comparés avec les valeurs expérimentales. Les cations actinide ont montré une sensibilité à la nature et géométrie de leur première sphère de coordination. Il a été mis en évidence que le cation NpVI (5f1) possède un état fondamental sensiblement affecté par la modification de la symétrie du complexe. A partir des niveaux électroniques calculés, des premiers calculs de spectres d’absorption de ces mêmes complexes ont pu être réalisés. L’absorbance principale calculée est en bon accord avec les spectres d’absorption expérimentaux malgré un décalage systématique des spectres calculés vers le rouge, assimilable à un effet néphélauxétique.Dans un deuxième temps, l’utilisation de la Théorie de Bleaney a permis l’étude des déplacements chimiques et plus précisément, du terme de contact des complexes de symétrie C4 d’actinide au degré d’oxydation (+IV) avec le ligand DOTA (AnIV = ThIV, UIV, NpIV, PuIV). Cette contribution de contact a été accessible par la RMN de l’oxygène 17 (17O), atome directement lié au centre paramagnétique. Le DOTA a été enrichi en 17O avant la synthèse du complexe en phase organique DMSO/CHCl3. Ces complexes ont été caractérisés par spectrophotométrie UV-Visible-NIR et spectroscopie RMN 1H et 13C. Une difficulté de synthèse a été rencontrée pour le complexe de ThIV-D17OTA, composante diamagnétique nécessaire à l’extraction des termes de contact purement paramagnétiques. D’autres voies de synthèses ont été explorées.Mots Clés : Actinides, RMN, Paramagnétisme, Susceptibilité magnétique, Déplacement chimique, DOTA.2018 – Commissariat à l’Energie Atomique et aux Energies Alternatives – Laboratoire d’interactions Ligand-Actinide – France “Study of actinide’s paramagnetic behavior in solution with cyclic polyaminocarboxylate ligands”The actinide cation’s (5f elements) paramagnetic behavior may be studied by liquid NMR spectroscopy. Two complementary lines of research have been pursued: molar magnetic susceptibility and chemical shift.Firstly, magnetic susceptibility is easy to determine by the Evans’ method when there is no interaction between actinide cations and ligands. This method, with samples in solution at room temperature, has been compared to SQUID measurements using solid samples at very low temperatures for the [NpO2(DPC)2Li2] complex. Both methods produce molar magnetic susceptibilities with the same order of magnitude even if this compound is not the best one to the comparison.The Evans’ method has been used to complete experimental data from literature. The molar magnetic susceptibility measurement in a non-complexing medium for the PuVO2+ (5f3) cation has been measured in the laboratory. Molar magnetic susceptibility calculations were carried out using the SO-CASPT2 method for (+IV), (+V) and (+VI) actinide cations (AnIV= UIV, NpIV, PuIV and AnV/VI: NpV/VI, PuV/VI) in a non-complexing medium, then in chloride and nitrate complexing media. They have been compared with experimental values. The molar magnetic susceptibilities of actinide cations have been shown to be sensitive to the nature and geometry of their first coordination sphere. It has been revealed that the fundamental state of NpVI (5f1) cation is affected by changing the symmetry of the complex. From calculated electronic states, first absorption spectra calculations of these complexes have been carried out. A good matching between major calculated and experimental absorbances has been obtained. A red-shift was applied to the calculated absorption spectra to fit better with the experimental ones. This shift may be related to a nephelauxetic effect.Secondly, the use of Bleaney’s Theory has allowed the study of chemical shifts. And precisely, this work has been focused on the contact contribution for C4 symmetry AnIV complexed with DOTA ligand (AnIV= ThIV, UIV, NpIV, PuIV). This contact contribution is observable via NMR of oxygen-17 (17O) because oxygen atoms are directly linked to the paramagnetic cation. Therefore, the DOTA ligand was enriched in 17O before the actinide complex synthesis in a DMSO/CHCl3 organic phase. These complexes have been characterized by UV-Visible-NIR spectrophotometry and 1H, 13C NMR spectroscopy. But, some synthesis difficulties have been encountered to the diamagnetic ThIV-D17OTA (5f0) complex. This diamagnetic component is required to extract pure paramagnetic contact contribution. In that case, other ways of synthesis have been investigated.Keywords: Actinides, NMR, Paramagnetism, Magnetic susceptibility, Chemical shift, DOTA ligand.2018 – Commissariat à l’Energie Atomique et aux Energies Alternatives – Laboratoire d’interactions Ligand-Actinide – France

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Pinède, Laurent. "Le traitement de la maladie thromboembolique veineuse des membres inférieurs : durée optimale de prescription des anticoagulants oraux : essai contrôlé multicentrique DOTAVK." Lyon 1, 2000. http://www.theses.fr/2000LYO1T010.

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28

Kerdjoudj, Rabha. "Scandium complexes : physico-chemical study and evaluation of stability in vitro and in vivo for nuclear medicine application." Thesis, Nantes, Ecole des Mines, 2014. http://www.theses.fr/2014EMNA0191/document.

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Parmi les différents isotopes du Scandium qui peuvent être utilisés en médecine nucléaire, on peut citer le ⁴⁷Sc et le ⁴⁴Sc. Le premier se désintègre en émettant un électron associé à un gamma de 159 keV et peut donc être utilisé soit pour faire de la radiothérapie, soit de l’imagerie TEMP. Le ⁴⁴Sc (3.97 h) se désintègre dans 94.27 % des cas en émettant un positron, accompagné d’un photon γ d’énergie égale à 1.157 MeV. Cet isotope est alors un candidat idéal pour des applications en imagerie TEP. Actuellement, le Cyclotron de haute énergie et haute intensité Arronax produit le ⁴⁴Sc et coproduit son état isomérique le ⁴⁴mSc (2.44 j). Le ⁴⁴mSc a des propriétés (Eᵧ=270 keV, 98.8 %) qui permet d’envisager son utilisation comme potentiel générateur in vivo. Les travaux précédents ont permis de montrer que le ligand DOTA est le plus adapté et le plus stable pour le Sc. Ce travail de thèse a pour but de mettre en évidence la faisabilité du générateur in vivo ⁴⁴m/⁴⁴Sc. Dans un premier temps une procédure a été optimisée et validée pour la production du ⁴⁴m/⁴⁴Sc avec une haute activité spécifique et pureté chimique. Le radiomarquage sur des peptides contenant du DOTA a été ensuite développé et optimisé. Des études théoriques et expérimentales ont été réalisées dans le but de démontrer la faisabilité du ⁴⁴m/⁴⁴Sc comme potentiel générateur in vivo. En fin des études de stabilité in vitro sur des complexes radiomarqués du ⁴⁴m/⁴⁴Sc suivi d’études de biodistribution et d’imagerie TEP ont été réalisées Among the different isotopes of Scandium that can be used in nuclear medicine may be mentioned the ⁴⁷Sc and ⁴⁴Sc. The first decays by emitting an electron associated with a 159 keV gamma can thus be used either for radiotherapy or TEMP imaging. The ⁴⁴Sc (3.97 h) decays in 94.27% in case by emitting a positron, with a γ photon energy equal to 1.157 MeV. This isotope is then an ideal candidate for applications in PET imaging. Currently, the Cyclotron of high energy and high intensity ARRONAX produce ⁴⁴Sc and co-produces the isomeric state the ⁴⁴mSc(2.44 d). The ⁴⁴mSc has properties (Eᵧ = 270 keV, 98.8%), which allows to consider its use as a potential in vivo generator. Previous work had demonstrated that the DOTA ligand is most suitable and stable for Sc. This thesis aims; make in evidence the feasibility of the in vivo ⁴⁴m/⁴⁴Sc generator. Initially a procedure was optimized and validated for the production of ⁴⁴m/⁴⁴Sc with a high specific activity and chemical purity. Radiolabeling of DOTA conjugated peptides was then developed and optimized. Theoretical and experimental studies have been performed in order to demonstrate the feasibility of ⁴⁴m/⁴⁴Sc as a potential in vivo generator. Finally, in vitro stability studies on radiolabeled ⁴⁴m / ⁴⁴Sc complexes were performed, followed by biodistribution studies and PET imaging

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29

Fiegel, Vincent. "Radiolyse alpha des acides polyaminocarboxyliques en solution aqueuse : cas du ligand DOTA." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTS024.

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La stabilité radiolytique du ligand DOTA (acide 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetique), choisi comme ligand modèle de la famille des acides polyaminocarboxyliques, a été étudié par irradiation externe au moyen de faisceau d’hélions ou par rayonnement gamma ainsi que par irradiation interne par introduction de radioéléments directement dans la solution. Les rendements radiolytiques de formation de certaines espèces dans le milieu (H2, CO2, H2O2, HNO2…) ont été déterminés et les produits de dégradation du ligand ont été identifiés en faisant varier la concentration de ligand DOTA, d’ions nitrate ainsi qu’en introduisant des cations métalliques dans la solution.Il a été montré qu’en solution le ligand DOTA est principalement dégradé par effet indirect du rayonnement dû aux espèces formées par radiolyse de l’eau (e_aq- , H• et HO•). DOTA peut réagir avec les radicaux H• et HO• conduisant à la formation de différents radicaux organiques suite à l’abstraction d’un atome d’hydrogène. Ces radicaux peuvent évoluer par rupture de liaison C-C ou N-C en libérant une molécule de dioxyde de carbone (CO2) ou un bras carboxylate (CH2COOH) ou encore par recombinaison avec un radical HO•. En présence d’acide nitrique, les ions nitrate vont piéger une partie des espèces réactives du milieu (e_aq- , H• et HO•) et protéger le ligand de sa dégradation. Lorsque le ligand est engagé dans une complexe avec un cation métallique, l’addition de radicaux HO• sur le complexe est favorisée alors que la dégradation du ligand par décarboxylation est défavorisée. Enfin, l’introduction de radioéléments dans une solution de DOTA a montré l’existence de phénomène de radiolyse direct important dans le milieu en plus des effets indirects The radiolytic stability of the DOTA ligand (1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid), chosen as a reference ligand of the polyaminocarboxylic acid family, has been studied by ex-situ irradiation with helium ion beams or gamma irradiation and by in-situ irradiation by direct introduction of radionuclides in the solution. Formation yields of some species (H2, CO2, H2O2, HNO2…) have been determined and the degradation products of DOTA identified by varying the concentrations of DOTA ligand and nitric acid, as well as by introducing metallic cations in solution.It has been shown that the DOTA ligand is mainly degraded in solution by the indirect effect of ionizing radiation, due to the species formed by water radiolysis (e_aq- , H• and HO•). DOTA can react with H• and HO• radicals leading to the formation of DOTA radicals after hydrogen abstraction. These radicals can further evolve by C-C or N-C bond cleavage, leading to the loss of carbon dioxide moieties (CO2) or a carboxylate arm (CH2COOH) and by recombination with a HO^• radical. In the presence of nitric acid, nitrate ions tend to protect the ligand from degradation by scavenging the reactive species in solution (e_aq-, H• and HO•). When the ligand is involved in a metallic complex, the addition of HO• radicals is promoted whereas the decarboxylation is limited. The introduction of radionuclides in the DOTA solution showed that the ligand undergoes significant direct radiolysis in addition to the indirect effects

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30

Bush, John Peyton. "The Stimulation of Dendritic Cells by Cationic Lipids." UKnowledge, 2019. https://uknowledge.uky.edu/medsci_etds/10.

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The discovery that cationic lipids can independently stimulate the immune system has generated interest in their potential as vaccine adjuvants. Here, we show that the cationic lipid R-DOTAP can independently stimulate type 1 interferon production in dendritic cells in both primary culture and immortalized cell culture. Levels of type 1 interferon production are cell line-dependent and limited in vitro by lipid-induced cell death. We show that cationic lipids can independently activate TLR-7 and TLR-9, suggesting a mechanism for type 1 interferon induction. This TLR-stimulatory activity is not restricted to R-DOTAP and can be extended to other similar cationic lipids in a lipid-specific and TLR-specific manner.

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Andersson, John, and Oskar Alin. "Analyzing Factors Contributing to the Success of a Team in Dota 2." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230202.

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Competitive gaming or E-Sport is more popular than ever, this has resulted inan increase in the number of players and tournament prize pools. In traditionalsports demographic factors have been shown to have high predictive power whenit comes to determining a country's success in the Olympic Games. Similarresults have been found when it comes to E-sport which is why it is interestingto investigate whether there are any dierences between regions in Dota 2 aswell. The goal is to analyze factors that contribute to the success of a Dota 2team by building a multiple-regression model. All data is collected from opensources and contains 55 active Dota 2 teams that have been playing between2011 - 2018. The factors in the nal model is the sum of the individual playersestimated skill, the skill dierence between the highest and lowest rated playerson the team, the number of games the team has played and organization region.The result gives an insight in what a person or organization would want to lookat when researching a team as well as a model that can be used to predict howgood a team will perform. Professionell gaming även kallat E-Sport (Elektronisk Sport) är mer populärt än någonsin. Detta har resulterat i allt fler spelare och högre prispotter i tävlingsevenemang. För traditionell sport har demografiska faktorer visat sig vara viktiga när det kommer till att förutsäga ett lands framgång i de Olymp- iska spelen. Liknande resultat har även observerats när det kommer till E-Sport vilket är varför det är intressant att undersöka huruvida det är någon skillnad mellan regioner för Dota 2. Målet är att analysera de faktorer som bidrar till framgång för ett Dota 2 lag genom en multipel linjär regressionsmodell. All data är insamlad från publika databaser och innehåller 55 aktiva Dota 2 lag som har spelat mellan 2011 2018. Faktorerna i den slutgiltiga modellen är summan av spelarnas uppskattade individuella skicklighet, skillnaden i rating mellan den högst och lägst rankade spelaren i laget, antalet matcher som laget spelat och vilken region laget kommer från. Resultatet ger en uppfattning om vilka faktorer som är relevanta för en person eller organisation som skulle vilja studera ett lag samt en modell som kan användas för att förutsäga hur pass bra ett lag kan prestera.

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Viro, Sebastian. "Using statistics and game knowledge to create better bots in Dota 2." Thesis, Malmö universitet, Fakulteten för teknik och samhälle (TS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-43442.

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Multiplayer online battle arena (MOBA) games and games in general offer developers opportunities to design and test AI to further push research within the area. MOBA is a genre that has seen an increase in popularity during recent years alongside a rapidly growing esports scene. The game's main purpose is ultimately to be enjoyed and played by human players, who often come up with and are encouraged to create their own strategies in order to beat the game or win out over their opponents. This thesis will explore how mimicking human behavior in AI and using statistics from human players can be beneficial to AI design. The AI will be developed in a framework similar to that used by the Conference of Games for their Dota 2 5v5 AI competition. Three different strategies will be created, each of which will mimic some aspect of human behaviour, and then tested against the built-in AI in Dota 2. All the developed AI’s managed to win with varying results. The results showed some support for the notion that human gameplay and statistics can be beneficial to AI design. There are, however, difficulties with the complexity of the game that is Dota 2.

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Akanji, Akinkunmi Ganiyu. "Estudo de conjugação do anticorpo anti-CD20 para marcação com radionuclídeos metálicos ou lantanídeos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-06092017-084114/.

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Linfomas são cânceres que se iniciam a partir da transformação maligna de um linfócito no sistema linfático. Os linfomas são divididos em duas categorias principais: os linfomas de Hodgkin e todos os outros linfomas, denominados linfomas não-Hodgkin (LNH). Os pacientes com LNH são comumente tratados com radioterapia apenas ou combinada com quimioterapia utilizando-se de anticorpo monoclonal anti-CD20, principalmente o rituximab (MabThera&reg). O uso de anticorpos monoclonais (Acm) conjugados à quelantes bifuncionais radiomarcados com radionuclídeos metálicos ou lantanídeos é uma realidade de tratamento para portadores de LNH pelo princípio de radioimunoterapia (RIT). Este estudo concentrou-se nas condições de conjugação do anticorpo monoclonal rituximab (MabThera&reg) com grupamentos quelantes bifuncionais DOTA e DTPA. Na marcação dos Acm conjugados com lutécio-177, foram estudadas as condições de pré-purificação do Acm, condições de conjugação, determinação de número de quelantes acoplados à molécula do anticorpo, purificação do anticorpo conjugado, radiomarcação do anticorpo conjugado, com lutécio-177, purificação do anticorpo marcado, a ligação específica in vitro dos compostos marcados às células Raji, e distribuição biológica em camundongos BALB/c sadios. As três metodologias empregadas na pré-purificação do anticorpo (diálise, cromatografia de exclusão molecular com coluna Sephadex G-50 e ultrafiltração) demonstram-se eficientes e proporcionaram recuperação da amostra superior a 90%. A metodologia de ultrafiltração foi considerada a mais simples e prática, podendo ser aplicada a procedimentos rotineiros de produção de radiofármacos. Além disso, proporcionou a recuperação final de amostra de 97% em microlitros. Nas conjugações do anticorpo com os quelantes DOTA e DTPA em razões molares diferentes do Acm:quelante, observou-se número de grupamentos quelantes acoplados à molécula do Acm proporcional à razão molar estudada. Quando foi avaliada a influência de condições diferentes de conjugação no número de quelantes acoplados à molécula do Acm, não foram observadas diferenças significativas, com resultados de pureza radioquímica (PR) inferior a 80% em todas as condições estudadas. Na comparação de métodos de purificação do Acm conjugado, a abordagem inédita apresentada neste estudo, na qual a cromatografia de exclusão molecular foi combinada com a ultrafiltração resultou em maior eficiência na purificação e preservação da estrutura do anticorpo. Nos estudos de radiomarcação do anticorpo conjugado com DOTA e DTPA, os imunoconjugados de DTPA apresentaram, de forma geral, maior eficiência de marcação com resultados reprodutíveis quando comparados com os imunoconjugados de DOTA, considerando-se as diferentes razões molares utilizadas. As metodologias cromatográficas empregadas no controle de pureza radioquímica do composto radiomarcado proporcionaram a discriminação das diferentes espécies radioquímicas no meio de marcação. A metodologia de purificação do composto conjugado e radiomarcado utilizada proporcionou a obtenção de compostos com alta pureza radioquímica, 97,4±1,3% (DOTA 1:50) e 98,7±0,2% (DTPA 1:50). Nos estudos de ligação específica às células tumorais Raji, o anticorpo conjugado com quelante DTPA nas razões molares de 1:50 e 1:20 apresentaram perfil semelhante de ligação, com aumento da porcentagem de ligação específica proporcional à concentração celular, enquanto que o imunoconjugado na razão molar de 1:10 apresentou alta porcentagem de ligação não específica. Os resultados obtidos nos estudos de biodistribuição in vivo do anticorpo conjugado e radiomarcado nem sempre se mostraram compatíveis com a biodistribuição de anticorpos radiomarcados íntegros. No caso do quelante DOTA, o imunoconjugado obtido a partir da razão molar 1:20, apresentou melhores características de biodistribuição. No caso do quelante DTPA, a razão molar utilizada pareceu refletir diretamente no clareamento sanguíneo do anticorpo e todas as razões molares utilizadas apresentaram instabilidade in vivo. Lymphomas are malignancies or cancers that start from the malign transformation of a lymphocyte in the lymphatic system. Lymphomas are divided in two major categories: Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Patient with NHL are generally treated with radiotherapy alone or combined with immunotherapy using monoclonal antibody rituximab (MabThera&reg). Currently, monoclonal antibodies (Mab) conjugated with bifunctional chelate agents and radiolabeled with metallic or lanthanides radionuclides are a treatment reality for patients with NHL by the principle of radioimmunotherapy (RIT). This study focused on the conditions of conjugation of Acm rituximab (MabThera&reg) with bifunctional chelating agents DOTA and DTPA and labeling with 177-luthetium. Various parameters were studied: method of Acm purification, conditions of Acm conjugation and the determination of the number of chelate coupled to the Acm, the purification of the conjugated Mab, labeling conditions with lutetium-177, purification of the radiolabeled immunoconjugate, radiochemical purity (RP), in vitro specific binding determination to Raji cells (Human Burkitt) and biological distribution performed in normal BALB/c mouse. The three methodologies employed in pre-purification of Acm (dialysis, size exclusion chromatograph and ultrafiltration) demonstrated to be efficient; they provided sample recovery exceeding 90%. However, the methodology of ultrafiltration resulted in greater sample recovery and in microliters. The number of chelate attached to the Mab molecule was proportional to the molar ratio studied. When the influence of different conditions of conjugation in the number of chelate bounded to the Mab was studied, no notable differences were observed. The RP < 80% was observed in all the methods applied. Purification of the conjugated antibody by different methods showed that the innovative combination of Sephadex and ultrafiltration methods resulted in higher efficiency of purification. The optimized conditions for purification of the conjugated antibody preserved the protein integrity. Radiolabelling studies of DOTA and DTPA immunoconjugated showed that DTPA derivatives presented, in general, radiochemical yield superior than DOTA conjugated Mab, considering the different molar ratios studied. The chromatographic methods employed in the RP determination were efficient to separate the different radiochemical species presented in the reaction medium. The methodology used in the purification of the labeled Mab resulted in labeled compounds with high radiochemical purity, 97.4±1.3% (DOTA 1:50) and 98.7±0.2% (DTPA 1:50). Considering specific cell binding assays (Raji cells), the Mab conjugated to DTPA at 1:50 and 1:20 molar ratios presented similar results, and the percent of cell binding were proportional to the cell concentration, whereas the cell binding for 1:10 molar ratio showed high percent of nonspecific cell binding. The results of in vivo biodistribution studies of labeled Mab not always were compatible with the biodistribution of intact radiolabelled antibody. The DOTA immunoconjugated produced at 1:20 molar ratio, showed better performance in biodistribution studies. In the case of DTPA immunoconjugated, the blood clearance seems to be influenced by the molar ratio applied and the immunoconjugated produced with DTPA chelate at different molar ratio resulted in high in vivo instability compounds.

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34

Kannengießer, Stefanie [Verfasser], and Thomas [Akademischer Betreuer] Fanghänel. "Optimization of the Synthesis of Ac-225-labelled DOTA-Radioimmunoconjugates for Targeted Alpha Therapy, based on Investigations on the Complexation of Trivalent Actinides by DOTA / Stefanie Kannengießer ; Betreuer: Thomas Fanghänel." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177148838/34.

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35

Paakkonen, Johan. "Surfactants in anionic latex films." Thesis, Karlstads Universitet, Avdelningen för kemi och biomedicinsk vetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-6389.

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Domingo, Rommel J. "Pre-targeted radioimmunotherapy with streptavidin-CC49 monoclonal antibody and §9§0Y-DOTA-biotin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29337.pdf.

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ALDEGHERI, ELIANE B. "Avaliacao in vivo e in vitro do dota-lanreotideo radiomarcado com galio-67." reponame:Repositório Institucional do IPEN, 2005. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11372.

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Made available in DSpace on 2014-10-09T12:51:13Z (GMT). No. of bitstreams: 0 Made available in DSpace on 2014-10-09T14:09:36Z (GMT). No. of bitstreams: 1 11255.pdf: 3481749 bytes, checksum: 00aea80e8fd8e4ad3fbe875c87600b5c (MD5) Tese (Doutoramento) IPEN/T Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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38

Widin, Viktor, and Julien Adler. "On using Artificial Neural Network models to predict game outcomes in Dota 2." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-209270.

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Dota 2 is an online strategy game, played in a five versus five format. Its multitude of selectable characters, each with a unique set of abilities and spells, causes every new match to be different from the last and picking the right characters can ultimately decide whether a team wins or loses a game. This report investigates if Artificial Neural Networks can be used to predict game outcomes, based solely on the character selection made in each game. Additionally, the report will explore if altering the base parameters of the utilized ANN models can improve predictive performance. The models considered in the thesis will thus vary in number of hidden neurons and hidden layers in the neural network. The results show that the various models have an average prediction accuracy ranging between 53-59%. We find that using a low number of neurons with many layers improves prediction accuracy. Although the results from this study seem to indicate a correlation between character picks and game outcomes, we recommend a more extensive analysis be conducted in order to reproduce these results and thus ensure external validity. Dota 2 är ett strategispel som spelas online i ett fem mot fem format. Spelets stora mängd av valbara karaktärer, var och en med en unik uppsättning av egenskaper, leder till att varje match är olik den senaste och att välja rätt karaktär kan i slutändan avgöra om ett lag vinner eller förlorar en match. Denna rapport undersöker om Artificiella Neurala Nätverk kan användas för att förutspå matchresultat, baserat helt på vilka karaktärer som väljs i varje match. Vidare kommer rapporten utforska om ändringar i parametrarna för de ANN modeller som används kan förbättra prediktiv förmåga. Modellerna som hanteras i denna avhandling varierar därför i antalet gömda noder och lager i det neurala nätverket. Resultaten visar att de olika modellerna i genomsnitt förutspår matcher med 53-59% säkerhet. Genom att använda få neuroner med många lager förbättras modellernas prediktiva förmåga. Fastän resultaten från denna rapport tycks antyda en korrelation mellan vilka karaktärer som väljs och matchresultat, rekommenderar vi att en mer omfattande analys utförs i syfte att upprepa dessa resultat och således garantera extern validitet.

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39

Ilya, Musabirov. "Deconstructing Fame : An Analysis of eSports Brand Value. The Case of Dota 2." Thesis, Uppsala universitet, Medier och kommunikation, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-296411.

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40

Poret, Benjamin. "Développement d'analogues urotensinergiques radiomarqués pour l'imagerie de tumeurs solides." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR028/document.

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La surexpression de récepteurs couplés aux protéines G (RCPG) dans certains cancers est mise à profit en médecine nucléaire pour développer des radioligands capables de diagnostiquer la présence de tumeurs. A titre d’exemple, des analogues de la somatostatine marqués à l’indium-111 (111In-OctreoScan) sont utilisés pour le diagnostic de tumeurs neuroendocrines. L’urotensine II (UII), qui présente des homologies structurales avec la somatostatine, est considérée comme le neuropeptide vasoactif le plus puissant découvert à ce jour. L’UII interagit avec un unique RCPG de très haute affinité appelé UT, classiquement couplé à la voie Gαq/PLC/IP3/Ca2+. L’UII exerce notamment des activités pro-mitotiques et chémoattractantes et une expression élevée de l'UT a été rapportée dans plusieurs types de tumeurs solides humaines provenant des poumons, de l'intestin, de la prostate ou du sein. Ces données suggèrent que l'UT pourrait être une cible prometteuse pour concevoir des analogues urotensinergiques radiomarqués à finalités diagnostiques voire thérapeutiques. Deux analogues urotensinergiques capables de lier des isotopes radioactifs (le DOTA-UII et le DOTA-urantide) ont été synthétisés et radiomarqués avec succès avec l’111In. L'incubation de l’111In-DOTA-UII dans du plasma humain a révélé que seulement 30% du radioligand étaient dégradés après 3 heures d’incubation. L'administration de concentrations croissantes de DOTA-UII et de DOTA-urantide sur des cellules HEK-293 exprimant l'UT induit une augmentation dose-dépendante de la concentration cytosolique de calcium, avec une puissance et une efficacité similaires à celles obtenues avec l'UII (EC50: 1,26 10-8 M et 2,09 10-8 M, UII et DOTA-UII, respectivement) et urantide (EC50: 1,82 10-8 M et 1,52 10-8 M, urantide et DOTA-urantide, respectivement). Alors que la fixation sur l’UT du DOTA-UII ou l’UII entraîne l'internalisation du complexe ligand-récepteur (ELISA et immunocytochimie) dans les cellules HEK-293 exprimant l'UT, l’urantide et le DOTA-urantide restent inactifs. L'injection intraveineuse de l’111In-DOTA-UII chez des souris C57BL/6 a révélé un léger signal principalement restreint dans les reins, indiquant une clairance rapide du peptide. Des résultats similaires ont été obtenus avec des souris dont le gène codant l’UT a été invalidé (mUTS2R-/-) ou des souris exprimant constitutivement la forme humaine de l’UT (mUTS2R-/- hUTS2R+/+). Enfin, l’111In-DOTA-UII a été injecté chez des souris Nudes porteuses de xénogreffes hétérotopiques de cellules humaines A549 (adénocarcinome pulmonaire) ou DLD-1 (adénocarcinome colorectal), exprimant fonctionnellement l’UT, comme nous l’avons préalablement vérifié par analyses western blot, par immunohistochimie et par des tests de migration/prolifération cellulaire. Dans les deux cas, l'imagerie TEMP/TDM n'a toutefois pas révélé de signal exploitable dans les tumeurs, suggérant que la clairance du radioligand est trop importante pour permettre l'accumulation du radiotraceur et la détection des tumeurs. L’ensemble de nos résultats démontre que la conjugaison de DOTA dans les analogues urotensinergiques n'altère pas l'activation de l'UT. Cependant, d'autres investigations sont nécessaires pour diminuer la clairance rénale et améliorer l'imagerie tumorale et ainsi permettre, à terme, de concevoir des radioligands urotensinergiques à finalités diagnostiques voire théranostiques Overexpression of G protein-coupled receptors (GPCRs) in tumor is widely used to develop GPCR-targeting radioligands for solid tumor imaging. For example, somatostatin analogue labeled with 111Indium (111In-OctreoScan) is used for the diagnosis of neuroendocrine tumors. The vasoactive neuropeptide urotensin II (UII), which shares structural analogies with somatostatin, interacts with a single high affinity GPCR named UT. High expression of UT has been reported in several types of human solid tumors from lung, gut, prostate or breast, suggesting that UT is a valuable target to design radiolabeled UII analogues for cancer diagnosis. Two urotensinergic analogues (DOTA-UII and DOTA-urantide) both containing the DOTA chelating group capable of complexing radioactive metal isotopes have been synthetized and radiolabeled with 111Indium. Incubation of 111In-DOTA-UII in human plasma revealed that only 30% of the radioligand was degraded after a 3h incubation period. Administration of graded concentrations of both DOTA-UII and DOTA-urantide in the vicinity of HEK293 cells expressing UT induced a dose-dependent increase in cytosolic calcium concentration, with similar potency and efficacy to that obtained with UII and urantide. These results demonstrated that conjugation of DOTA in urotensinergic analogues did not affect UT activation. DOTA-UII was also able to promote UT internalization in HEK293 cells expressing UT, while DOTA-urantide was ineffective. Intravenous injection of 111In-DOTA-UII in C57BL/6 mice revealed a slight signal mostly restricted in kidney, and similar results were obtained with knock-out mice or constitutively expressing human UT mice. Finally, 111In-DOTA-UII was injected into nude mice bearing heterotopic xenografts of human A549 cells (lung adenocarcinoma) or DLD-1 cells (colorectal adenocarcinoma) both expressing functional UT. In both cases, SPECT-CT imaging showed the absence of tumor uptake and significant renal and bladder uptakes, suggesting fast tracer clearance from the organism. However, further investigations will be necessary to decrease renal clearance and to improve tumor imaging

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41

Hajjaj, Bouchra. "Conception, synthèse et évaluation biologique d’antagonistes de la bombésine pour la visualisation de cancers par imagerie médicale." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON13517.

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La surexpression des récepteurs GRP au niveau de différents types de cancers communs offre la possibilité d'utiliser des analogues radiomarqués de la bombésine pour leur diagnostic et leur traitement. Ce travail de thèse est consacré à la conception, la synthèse et l'évaluation biologique de nouveaux radiopharmaceutiques, contenant un antagoniste des récepteurs GRP, un bras espaceur et le chélatant cyclique DOTA. Nous avons tout d'abord déterminé la longueur du bras espaceur permettant une optimisation des propriétés biologiques. Puis en se basant sur les résultats de cette étude nous avons réalisé la synthèse et l'évaluation biologique de radio-ligands constitués d'antagonistes originaux des récepteurs GRP. Ces antagonistes ont été conçus en se basant sur le composé JMV 594, un antagoniste puissant de la bombésine synthétisé dans notre laboratoire. En plus de modifications réalisées sur ce peptide, des dimères ont également été synthétisés de façon à obtenir des antagonistes plus stables et plus affins pour les récepteurs GRP The abundant expression of the GRP receptor in many frequently occurring cancers that inflict humans provides the opportunity to use radiolabeled bombesin analogs for their diagnosis and treatment. This postgraduate work is dedicated to the design, synthesis and biological evaluation of new radiopharmaceuticals. These are made up of a GRP receptor antagonist, a spacer and the cyclic metal chelating agent DOTA. We first determined the spacer length which has optimal biological properties. Moving forward from this study, different radio-ligands containing new bombesin antagonists have been synthesized and biologically evaluated. Those antagonists are based on compound JMV 594, a powerful bombesin antagonist synthesized in our laboratory. Besides modifications of this peptide also dimers have been made to obtain more stable bombesin antagonist with more affinity to the GRP receptor

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42

Garske-Román, Ulrike. "177Lu-DOTA-octreotate Radionuclide Therapy of Neuroendocrine Tumours : Dosimetry-Based Therapy Planning and Outcome." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183417.

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Peptide receptor radionuclide therapy for the internal radiation of neuroendocrine tumours expressing somatostatin receptors has made great advances and offers promising results. 177Lu-DOTA-octreotate is one of the most widely used radiopeptides, but kidneys and bone marrow are organs at risk. Methods of measuring radiation doses to at-risk organs and tumours (dosimetry) on an individual patient basis have been regarded as impracticable and a maximum of 4 treatment cycles has widely been accepted as the treatment standard instead. The first aim of this thesis was to establish a clinically feasible protocol to calculate absorbed doses to bone marrow and the kidneys during therapy with 177Lu-DOTA-octreotate. A new dosimetry protocol for the bone marrow was described. Dosimetry for solid organs had previously been described based on 3-dimensional imaging by the research group. In the current thesis it was demonstrated that in most patients only minor changes of the effective half-life occurred in the kidneys. By performing complete dosimetry during the first cycle and comparing it with the uptake in later cycles, it was shown that the absorbed dose can be cal-culated based on the activity concentration at 24 hours after therapy. The study concluded that 50% of all patients could receive more than the standard 4 treatment cycles with 7.4 GBq 177Lu-DOTA-octreotate without passing the limit of 23 Gray to the kidneys or 2 Gray to the bone marrow, whereas 20% would tolerate fewer than 4 cycles. The second aim was to describe treatment outcomes of dosimetry-guided therapy with 177Lu-DOTA-octreotate. Patients with metastasized colorectal neuroendocrine tumours and bronchial carcinoids were shown to have longer survival with this method than previously reported. Morphological tumour response could be correlated to time to progression. Furthermore, in a case of low-differentiated neuroendocrine cancer it was shown that large tumours with high proliferation can also be treated with this method and that tumour-to-risk organ ratios can improve in later cycles, resulting in a more effective treatment. Dosimetry-guided, fractionated radionuclide therapy with 177Lu-DOTA-octreotate is a valuable treatment option for patients with advanced neuroendocrine tumours expressing somatostatin receptors.

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Uhlmann, Robin [Verfasser]. "Die Peptid-Radio-Rezeptor-Therapie neuroendokriner Tumoren mit Yttrium-90-DOTA-NOC / Robin Uhlmann." Ulm : Universität Ulm, 2017. http://d-nb.info/1137264802/34.

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Vanezi, Maria [Verfasser]. "Fernmetastasierte neuroendokrine Tumoren des Pankreas: Ansprechen auf Radiopeptidtherapie mit 177Lu-DOTA-Octreotat / Maria Vanezi." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1218301716/34.

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45

Bulygin, Denis. "How do people evaluate virtual goods in social media? The case of Dota 2." Thesis, Uppsala universitet, Människa-datorinteraktion, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-389395.

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Virtual purchases are the main source of revenue for developers of F2P games being a market with expected 17.4 billions of dollars volume in 2019. Despite the broad scope of research of virtual purchases, it is still unclear how the player evaluate non-functional goods. Based on analysis of discussions of virtual decorative items this work what experiences nonfunctional items grants players with and how those experiences discussions reflect in the item’s price. With the use of Structural Topic Modeling framework this work demonstrates the dimensions of players’ experience in their association with price change on the case of Reddit.com subreddit /r/Dota2. Analysis reveals three main categories of discussions: dimensions of hedonic value, dimensions of social value, expectations mismatch. This work contributes to studies of virtual purchases by decomposing each category into experience dimensions and by revealing the relationship between extracted experience dimensions and items price.

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Webber, Benjamin Charles. "Investigation of the Structure and Dynamics of Regioisomeric Eu³⁺ and Gd³⁺ Chelates of NB-DOTMA: Implications for MRI Contrast Agent Design." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1498.

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The detection of disease and abnormal pathology by magnetic resonance imaging (MRI) has been aided significantly by the use of gadolinium (Gd3+)-based contrast agents (CAs) over the past three decades. MRI and MRI CAs play a critical role in diagnosing tumors and diseases of the central nervous system. The agents used clinically have been shown to safely increase MRI contrast despite the toxicity of Gd3+, owing to the high kinetic and thermodynamic stability of these chelates. However, current CAs enhance contrast at a small fraction of what is theoretically possible. This leads to the necessity of introducing high CA doses in practice in order to afford sufficient contrast. Lanthanide (Ln3+) chelates based on 1,4,7,10–tetraazacyclododecane–1,4,7,10–tetraacetate (DOTA) have been shown to be particularly stable and effective. Chelates of DOTA exist in two interconverting coordination geometries which have varying water exchange rates. Researchers have envisioned a way to increase the per-dose efficacy both by control of the Gd3+–inner–sphere water exchange rate and via binding specificity (i.e. to tumors). The efficacy gains using these approaches have thus far been modest. A thorough structural characterization of europium (Eu3+) chelates of a DOTA-derivative which cannot undergo conformational exchange was carried out. These studies show that a single enantiomer of the ligand (S)–2–(4-nitrobenzyl)–1,4,7,10–tetraazacyclododecane–1,4,7,10–tetra(α–methyl)acetate (NB–DOTMA) can yield chelates which are both diastereoisomeric (previously reported) and regioisomeric (not previously speculated). Molecular mechanics simulations generated from the characterization data indicate that the nitrobenzyl (NB) substituent is oriented in different directions for the two possible regioisomers. The NB group can be chemically converted to confer macromolecular binding capability, and the orientation of the NB substituent may have a significant impact on the binding and/or relaxation behavior of a prototypical CA. The nuclear magnetic resonance (NMR) spectra of Eu–NB–DOTMA at various temperatures were compared. Unexpectedly, the chelates showed time-averaged structures which differ with a change in water exchange rate — the faster the rate, the greater the deviation from the expected structure. Consideration of the structures of Ln3+ chelates without accounting for their dynamic behavior does not yield an accurate value for the time-averaged hydration state. These observations suggest the "optimal" water exchange rate calculated using Solomon-Bloembergen-Morgan (SBM) theory may not lead to the highest-efficacy CAs. Binding and relaxometric studies of macromolecule-targeting derivatives of Gd–NB–DOTMA both by the author and in another lab showed that the coordination isomer with the slower water exchange rate should lead to more effective contrast, in direct opposition to the prevailing view of water exchange in the MRI community. Preliminary data do not indicate that regioisomeric chelates have significantly different relaxivity or macromolecular binding behavior. The ratios between regioisomeric Ln–NB–DOTMA chelates formed were shown to be dependent on the concentration and pH of the chelation reaction, but conditions were not found which led to the production of a single regioisomer. Attempts to carry out an efficient synthesis of a Ln3+ chelate with no potential for regioisomerism were unsuccessful.

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Ixcol, Mus Carmelita Faustina. "El significado de los llamados “linchamientos” en Guatemala y las prácticas que los dotan de sentido. Un estudio desde las comunidades mayas." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/129091.

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La investigación trata del significado de los llamados “linchamientos” en Guatemala y analiza las prácticas que los dotan de sentido. Se trata de un estudio realizado desde las mismas comunidades mayas a fin de identificar construcciones de sentido asociadas a un entramado sociocultural que concibe e interpreta los llamados “linchamientos” desde un marco de inteligibilidad diferente al habitualmente establecido y que puede presumirse conectado con formas propias de resolución de conflictos. La pretensión de la tesis es romper con la comprensión de los llamados “linchamientos” como una mera expresión y respuesta irracional de una masa y examinarlos como un proceso social complejo. La indagación se llevó a cabo mediante metodología cualitativa, utilizando entrevistas como técnica de recogida de información. Para la realización del análisis se aplicó una combinación de análisis de contenido temático y análisis del discurso. Los resultados permiten identificar dos visiones en la comprensión de los llamados “linchamientos”: una visión oficial o gubernamental y otra que corresponde a las comunidades mayas. La primera permite identificar una cultura dominante que dicta los parámetros bajo los que se tiene que actuar y la segunda resiste defendiendo una cosmovisión propia en confrontación con la dominante. El discurso, las prácticas y las interpretaciones de los llamados “linchamientos” están configurados bajo la visión dominante o hegemónica que los utiliza para denostar y criminalizar las prácticas culturales indígenas y mayas. Sin embargo, en la cultura Maya no se maneja ni la noción de linchamiento (inexistente en el idioma) ni la comprensión occidental del mismo, sino que se recurren a visiones culturales fundamentadas en la interconexión, tales como poronik y k´otoj ch´i´aj. This research deals with the meaning of lynching in Guatemala and analyzes the practices that give meaning to them. This is a study realized from the perspective of the Mayan communities in order to identify constructions of meaning associated with a sociocultural background. It conceives and interprets the lynching from a different perspective than the one usually accepted and the phenomenon may be considered as a type of conflict resolution. The aim of this thesis is to take distance from a common understanding of a lynching as a simple way of expression and irrational response of the mass and, therefore, examine the phenomenon as a complex social process. The investigation was carried out by means of qualitative methodology, using interviews as a data collection technique. To perform the analysis we applied a combination of content analysis and discourse analysis. The results point out to two ways of understanding lynching. First, there is an official or governmental vision and, second, there is another vision that corresponds to the Mayan communities. The former is characterized by the influence of the dominant culture that dictates the parameters for everyone’s actions –ought to be, and the latter is about resistance of the people by defending their own worldview in confrontation with the ruling elite. The discourse, practices and interpretations of the lynching are configured under the dominant or hegemonic vision, from the state, which usually tends to vilify and criminalize indigenous and Mayans cultural practices. However, in the Mayan culture the notion of lynching (a nonexistent word in their language) is not applied nor understood in the Western way of thinking, but it is related to cultural understandings grounded in networking such as poronik and k´otoj ch´i´aj.

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48

Álvarez, Acuña Carlos, and Acuña Carlos Álvarez. "“ANÁLISIS Y PERSPECTIVAS AL DOTAR DE AUTONOMÍA AL SISTEMA DE AGUAS DE LA CIUDAD DE MÉXICO EN MATERIA FINANCIERA Y DE GESTIÓN”." Tesis de Licenciatura, Facultad de Ciencias Políticas y Sociales, 2014. http://hdl.handle.net/20.500.11799/13694.

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La problemática del agua potable ha sido un tema crucial que debe ser atendido por las autoridades en conjunto con la sociedad, puesto que se ven afectados los intereses sociales, políticos y ambientales. El otorgarle autonomía plena al órgano encargado de administrar el sistema hidráulico de la Ciudad de México, permitirá un manejo eficaz de los recursos que le son encomendados. Aunado a ello, si se respalda la descentralización mediante la Gestión Integral de los Recursos Hídricos (GIRH) coadyuvará a la efectividad en su gestión técnica y financiera. En el Distrito Federal, el sistema de agua potable, drenaje, alcantarillado y disposición de aguas residuales está a cargo del órgano desconcentrado denominado, Sistema de Aguas de la Ciudad de México (SACM), el cual, se encuentra sectorizado a la Secretaría de Medio Ambiente del Distrito Federal, además de estar sujeto a la Tesorería para el cobro de tarifas y de la Secretaría de Obras Públicas para la construcción de obra hidráulica. Estas tarifas por el cobro del suministro de agua potable, son autorizadas por la Asamblea Legislativa del Distrito Federal (ALDF) a propuesta del Jefe de Gobierno. El SACM, encargado de la distribución de agua potable, cuenta con un sistema hídrico de 50 años de antigüedad, fugas de enorme magnitud y tuberías dañadas, lo cual, da como resultado un desperdicio de agua potable que representa 40% de ésta. En la Ciudad de México, se han provocado daños al medio ambiente, puesto que al no haber agua ya en los mantos acuíferos de esa ciudad, ha sido necesario extraerla fuera de su territorio, afectando fuertemente a los ecosistemas. La infraestructura hidráulica existente dentro de la Ciudad de México se encuentra deteriorada, sin embargo, el presupuesto asignado al SACM, esta etiquetado, impidiéndole invertir en las necesidades prioritarias de la sociedad.

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49

Moreau, Juliette. "Propriétés thermodynamiques, données structurales et mécanismes de formation des complexes de l'acide 1,4,7,10-tétraazacyclododécane - 1,4,7,10-tétraacétique et de son dérivé tétracarboxyethyl avec Eu3+, Gd3+ et Tb3+." Reims, 2003. http://www.theses.fr/2003REIMS017.

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La stabilité thermodynamique des complexes formés en solution entre les ions lanthanides (Eu3+, Gd3+ et Tb3+) et deux ligants tétraazacyclododécane polycarboxylique (DOTA et tétracarboxyéthylDOTA) a été étudiée par protométrie. Ces études ont confirmé la grande stabilité de ces composés et ont montré que leur cinétique de formation était très lente. Les composés thermodynamiquement stables résultent de la lente réorganisation en plusieurs étapes d'espèces intermédiaires. Le nombre moyen de molécules d'eau coordinées au lanthanide dans les différents complexes formés et déterminé par luminescence et EXAFS. Cette dernière méthode a permis de préciser la nature des atomes donneurs entourant le métal et les longueurs des liaisons correspondantes. Les résultats obtenus permettent de proposer pour chaque ligant, un mécanisme réactionnel conduisant, en trois étapes, de l'ion lanthanide hydraté aux complexes stables The thermodynamic stability of lanthanide ions (Eu3+, Gd3+ et Tb3+) complexes with two tetraazacyclododecane polycarboxylic ligands (DOTA and tetracarboxyethylDOTA) was studied by potentimetry. This study confirmed the important stability of this compounds and showed that the kinetic of thier formation was very slow. Several reorganisation steps involving intermediates species are necesseray to obtain the thermodynamic stable compounds. In order to characterize these complexes, luminescence and EXAFS spectroscopy studies were carried out, leading to the determination of the mean number of water molecules coordinated to the lanthanide cations. This last method, applied to complexesallowed us to precise the nature of the donor atoms that surround the metal and the corresponding binding lengths. This results have allowed us to propose a reactional mechanism for each ligand, starting from the hydrated lanthanide ion and leading in three steps to the final stable complexes

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Dotta, Alexandre Godoy. "Política pública da educação superior no Brasil : a efetividade da avaliação institucional no ambito do sinaes / Alexandre Godoy Dotta ; orientadora, Ana Maria Eyng." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2009. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=1514.

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Dissertação (mestrado) - Pontifícia Universidade Católica do Paraná, Curitiba, 2009 Inclui bibliografias A dissertação tem como tema a política de avaliação da educação superior proposta pelo Sistema Nacional de Avaliação da Educação Superior (SINAES), com ênfase na atuação da Comissão Própria de Avaliação (CPA). O estudo é de grande importância, pois a CPA The subject of this dissertation is the higher education assessment policy proposed by the 'Sistema Nacional de Avaliação da Educação Superior -SINAES' (National System for the Assessment of Higher Education) focusing the performance of the 'Comissão Próp

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Dissertations / Theses on the topic 'Dotlak'

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