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Journal articles on the topic 'Double antibiotic paste'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Sousa, Maurício Gonçalves da Costa, Patrícia Diniz Xavier, Ana Paula de Castro Cantuária, Ingrid Aquino Amorim, Jeeser Alves Almeida, Octavio Luiz Franco, and Taia Maria Berto Rezende. "Antimicrobial and immunomodulatory in vitro profile of double antibiotic paste." International Endodontic Journal 54, no. 10 (July 9, 2021): 1850–60. http://dx.doi.org/10.1111/iej.13576.

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2

Deepak, Anupama. "Comparison of Effects of Triple Antibiotic Paste , Double Antibiotic Paste and Proton Pump Inhibitor on E. faecalis- An Invitro Study." Bioscience Biotechnology Research Communications 13, no. 7 (August 25, 2020): 207–12. http://dx.doi.org/10.21786/bbrc/13.7/35.

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3

Ojha Tiwari, Urvashi, Afsana Begum, Jyoti Jain, Sandhya Yadav, and Nurez Anwar. "COMPARATIVE EVALUATION OF ANTIMICROBIAL EFFICACY OF TRIPLE ANTIBIOTIC PASTE AND MODIFIED DOUBLE ANTIBIOTIC PASTE USING DIFFERENT VEHICLES AGAINST CANDIDA ALBICANS." International Journal of Advanced Research 8, no. 1 (January 31, 2020): 528–33. http://dx.doi.org/10.21474/ijar01/10325.

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Jeon, Sang-Yun, Nan-Young Lee, and Sang-Ho Lee. "Pulp Revascularization of Infected Immature Permanent Teeth Using Platelet-Rich Fibrin and Double Antibiotic Paste : Case Report." JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY 40, no. 3 (August 30, 2013): 216–22. http://dx.doi.org/10.5933/jkapd.2013.40.3.216.

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Khoshkhounejad, Mehrfam, Mahsa Sobhi Afshar, Fereshteh Jabalameli, Mohammad Emaneini, and Mohammadreza Sharifian. "Cytotoxicity Evaluation of Minimum Antibacterial Values of Different Medicaments Used in Endodontic Regenerative Procedures." European Journal of Dentistry 13, no. 04 (October 2019): 514–20. http://dx.doi.org/10.1055/s-0039-3401369.

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Abstract Objectives This study aimed to evaluate the cytotoxicity of minimum antibacterial values of medicaments used in endodontic regeneration on stem cells. Materials and Methods “Minimum inhibitory concentration,” “minimum bactericidal concentration,” and “minimum biofilm inhibitory concentration” of triple and double antibiotic paste, a modified triple antibiotic paste (minocycline replaced by clindamycin), Augmentin, and calcium hydroxide were determined using Enterococcus faecalis (ATCC 29212) by microtiter plate method. Direct cytotoxic effects of drugs were evaluated by lactate dehydrogenase and water-soluble tetrazolium salt-1 assays using stem cells of apical papilla obtained from immature third molars via enzymatic digestion. Statistical Analysis Data were analyzed using IBM SPSS Statistics 24, one-way analysis of variance and post hoc comparisons. The statistical power was set at p < 0.05. Results All medicaments caused similar cytotoxicity and cell proliferation at “minimum inhibitory concentration” (p > 0.05) except Augmentin which was significantly more toxic than others (p < 0.05). At “minimum bactericidal concentration,” calcium hydroxide was more toxic than other drugs (p < 0.001), but its adverse effect on cell proliferation was the same as Augmentin (p > 0.05). Triple and double antibiotic paste revealed similar favorable effects in terms of toxicity and proliferation rate at most of the tested concentrations (p > 0.05). At “minimum biofilm inhibitory concentration” both the modified paste and Augmentin caused less proliferation rate than triple and double antibiotic paste (p < 0.001and p < 0.05, respectively) and Augmentin induced more cytotoxicity (p < 0.05). Conclusions Considering the antimicrobial potency, triple antibiotic paste seems to be the safest drug for the stem cells of apical papilla, while Augmentin may have some adverse effects.

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Sarıyılmaz, Evren, and Cangül Keskin. "Evaluation of Double and Triple Antibiotic Paste Removal Efficiency of Various Irrigation Protocols." Meandros Medical and Dental Journal 20, no. 2 (August 26, 2019): 129–36. http://dx.doi.org/10.4274/meandros.galenos.2018.63496.

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Zancan, Rafaela Fernandes, Bruno Cavalini Cavenago, Denise Ferracioli Oda, Clovis Monteiro Bramante, Flaviana Bombarda de Andrade, and Marco Antonio Hungaro Duarte. "Antimicrobial Activity and Physicochemical Properties of Antibiotic Pastes Used In Regenerative Endodontics." Brazilian Dental Journal 30, no. 6 (November 2019): 536–41. http://dx.doi.org/10.1590/0103-6440201902613.

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Abstract: The purpose of this study was to evaluate the pH, solubility and antimicrobial action of Calcium Hydroxide Paste (CH), Double Antibiotic Paste (metronidazole+ciprofloxacin-DAP), calcium hydroxide added to DAP (CH/DAP) and Triple Antibiotic Paste (metronidazole + ciprofloxacin+minocycline-TAP). pH (n=10) were measured by pHmeter. Root canals of acrylic teeth (n=10) were filled with the above-mentioned intracanal-dressings, immersed in ultrapure water, and solubility was measured by the difference between the initial and final volume (7,15 and 30 days) by using micro-computed tomography. Enterococcus faecalis biofilm was induced on bovine dentin disc surfaces (n=20), and treated with the pastes for 7 days. Percentage bacterial viability was verified by confocal microscope, with LIVE/DEAD dye. CH and CH/DAP presented the highest pH values. Regarding solubility, after 7 days, antibiotic groups presented significant volume loss. CH and CH/DAP showed no statistical difference compared with the Control in antimicrobial action against E. faecalis biofilm. However, TAP and DAP presented a significant percentage reduction in bacterial population. Due to high solubility of the pastes, renewing antibiotic dressings every 7 days, or using the medications for this period in regeneration protocols is recommended. DAP is indicated for killing E. faecalis in biofilm because it has antimicrobial action similar to TAP. Adding Calcium Hydroxide to DAP significantly decreased its antimicrobial action. In spite of its the low solubility and high pH values, the CH paste showed a low level of antimicrobial action against E. faecalis in biofilm.

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Yassen, Ghaeth H., Sarah S. Al-Angari, and Jeffrey A. Platt. "The use of traditional and novel techniques to determine the hardness and indentation properties of immature radicular dentin treated with antibiotic medicaments followed by ethylenediaminetetraacetic acid." European Journal of Dentistry 08, no. 04 (October 2014): 521–27. http://dx.doi.org/10.4103/1305-7456.143636.

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ABSTRACT Objective: The objective was to investigate the effect of intracanal antibiotic medicaments followed by ethylenediaminetetraacetic acid (EDTA) on the indentation properties and hardness of radicular dentin using a BioDent reference point indenter and a traditional microhardness technique, respectively. Materials and Methods: Specimens with intact root canal dentin surfaces and polished radicular dentin specimens were obtained from immature human premolars. Each type of specimen was randomly assigned (n = 10 per group) and treated with either double antibiotic paste (DAP) for 4-week followed by EDTA for 5 min, triple antibiotic paste (TAP) for 4-week followed by EDTA for 5 min, EDTA for 5 min or Hank's balanced salt solution (control). The BioDent reference point indentor and Vickers microhardness tester were used to measure the indentation properties of root canal surfaces and the hardness of polished dentin specimens, respectively. One-way ANOVA followed by Fisher's protected least significant differences were used for statistical analyses. Results: Both types of radicular dentin treated with antibiotic pastes and/or EDTA had a significant increase in the majority of indentation properties and a significant reduction in hardness compared to the untreated dentin. Furthermore, treatment of dentin with antibiotic pastes and EDTA caused significant increases in indentation properties and a significant reduction in hardness compared to EDTA-treated dentin. However, the RPI technique was not able to significantly differentiate between DAP + EDTA and TAP + EDTA-treated dentin. Conclusion: Dentin treated with antibiotic medicaments followed by EDTA had a significant increase the indentation properties and significantly reduction in hardness of radicular dentin.

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Madhukumar, Meenu, Praveena Geetha, KRadhakrishnan Nair, and Manu Unnikrishnan. "The effects of double antibiotic paste and amoxicillin-clavulanate paste used in endodontic regeneration on microhardness of radicular dentine: An In vitro study." Journal of Pharmacy And Bioallied Sciences 13, no. 5 (2021): 510. http://dx.doi.org/10.4103/jpbs.jpbs_531_20.

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GÖKTÜRK, Hakan, İsmail ÖZKOÇAK, Fevzi BÜYÜKGEBİZ, and Osman DEMİR. "The Effect of Different Irrigation Techniques on the Removal of Double Antibiotic Paste from the Root Canal." Turkiye Klinikleri Journal of Dental Sciences 23, no. 3 (2017): 166–73. http://dx.doi.org/10.5336/dentalsci.2017-55852.

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11

Jenks, Daniel B., Ygal Ehrlich, Kenneth Spolnik, Richard L. Gregory, and Ghaeth H. Yassen. "Residual antibiofilm effects of various concentrations of double antibiotic paste used during regenerative endodontics after different application times." Archives of Oral Biology 70 (October 2016): 88–93. http://dx.doi.org/10.1016/j.archoralbio.2016.06.006.

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GOKTURK, Hakan, Ismail OZKOCAK, Fevzi BUYUKGEBİZ, and Osman DEMİR. "An in vitro evaluation of various irrigation techniques for the removal of double antibiotic paste from root canal surfaces." Journal of Applied Oral Science 24, no. 6 (December 2016): 568–74. http://dx.doi.org/10.1590/1678-775720160286.

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Santos, Luciane Geanini Pena dos, Luiz Alexandre Chisini, Camila Guerner Springmann, Beatriz Dulcineia Mendes de Souza, Fernanda Geraldo Pappen, Flávio Fernando Demarco, Mara Cristina Santos Felippe, and Wilson Tadeu Felippe. "Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review." Brazilian Dental Journal 29, no. 5 (September 2018): 409–18. http://dx.doi.org/10.1590/0103-6440201802132.

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Abstract This systematic review aimed to evaluate whether alternative materials to conventional triple antibiotic paste (TAP - metronidazole, ciprofloxacin, and minocycline) and grey mineral trioxide aggregate (GMTA) could avoid tooth discoloration in teeth submitted to Regenerative Endodontic Procedure (REP). It was also investigated if dental bleaching is able to reverse the color of darkened teeth due to REP. The search was conducted in four databases (Medline via PubMed, Scopus, ISI Web of Science and BVS - Virtual health library), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The retrieved papers were uploaded in the software EndNoteTM and two reviewers independently selected the studies and extracted the data. Only studies in humans (case reports, case series, clinical trials) were included in the review. From 1,122 potentially eligible studies, 83 were selected for full-text analysis, and 38 were included in the review. The included studies were mainly case reports (76.3 %). The studies described a total of 189 teeth submitted to REP. From these, about 54% of teeth presented some degree of discoloration. Most teeth presenting color alteration were treated with TAP, especially when combined with GMTA. Only three studies performed dental bleaching to restore the color of teeth and neither bleaching technique was able to restore the original color of the crowns. The use of alternative materials to TAP and GMTA, such as double antibiotic paste or Ca(OH)2 pastes and white mineral trioxide aggregate or BiodentineTM, reduces the occurrence of tooth discoloration.

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Samrudhi Khatod, Anuja Ikhar, Pradnya Nikhade, Manoj Chandak, Kaustubh Khatod, Akshay Jaiswal, Madhulika Chandak, Chanchal Rathi, and Nidhi Motwani. "Comparative Evaluation of Different Irrigation Techniques with Conventional Irrigation Technique for the Removal of Double Antibiotic Paste from Root Canal-An in vitro study." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (September 28, 2020): 5578–83. http://dx.doi.org/10.26452/ijrps.v11i4.3194.

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Complete removal of infection, rendering root canal free of an organism is the prime aim of endodontic treatment. It cannot be achieved alone by biomechanical preparation due to the complexity of root canal treatment. Therefore the use of intracanal medicament is a must. The antibiotic paste is frequently used intracanal medicament, usually in regenerative cases. Hence the aim of the is to compare different irrigation technique for removal of double antibiotic paste from root canal through a stereomicroscope. 36 single-rooted were standardized to root length of 12mm then instrumented by Protaper rotary file up to size F4. Irrigation was done using sodium hypochlorite in between instrument change. The root canal was dried using paper point and filled by DAP and then randomly allocated to 3 groups(n=12) according to irrigation system used: conventional syringe irrigation (CSI), Passive ultrasonic irrigation(PUI), EndoVac (EV). Roots were then longitudinally sectioned using the diamond disk and studied under a stereomicroscope using a scoring scale. Data were evaluated using one way ANOVA and Tukey test. Among all experimental group CSI was least efficient. PUI and EV showed greater efficiency but no significant difference between PUI and EV, but a significant difference between CSI and PUI, EV (p< 0.05). Use of irrigation activation system results in efficient removal of DAP compared to CSI.

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Maniglia-Ferreira, Claudio, Eduardo Diogo Gurgel Filho, Fabio de Almeida Gomes, Sthefanny Amaral Reis, and Fernanda Geraldo Pappen. "12-Year Follow-Up of Regenerative Endodontic Treatment of Immature Permanent Upper Incisors with Acute Abscess." Brazilian Dental Journal 31, no. 6 (November 2020): 680–84. http://dx.doi.org/10.1590/0103-6440202003663.

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Abstract This case report discusses the endodontic treatment of a 7-year-old girl who suffered trauma (intrusion) to the immature upper central incisors secondary to a fall from a bicycle. Thirty days after the accident the patient was brought by her mother for clinical and radiographic assessment with a chief complaint of swelling and tenderness to percussion and palpation. Acute apical abscess associated with immature teeth were diagnosed. A decision was made to perform regenerative endodontic treatment. Access cavities were made and the root canals were disinfected by irrigation with 2.5% sodium hypochlorite. Final irrigation was performed with 17% EDTA. Due to pain and presence of secretions, 2% chlorhexidine gel was applied as an intracanal medicament. Seven days later, at the second visit, the root canals were once again disinfected and the canals of the right and left permanent upper central incisors were filled with double antibiotic paste (metronidazole/ciprofloxacin) and calcium hydroxide paste, respectively. Zinc oxide was mixed in both pastes. At the third visit, after 21 more days, the pastes were removed and the periapical areas were stimulated with a #80 K-file to encourage clot formation within the pulp cavities. A mineral trioxide aggregate (MTA) paste cervical plug was placed and the teeth were restored with glass ionomer cement. Radiographs and CBCT scans demonstrated complete root formations. The patient has been followed for 12 years, with evidence of clinical success throughout.

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Abouelenien, Sarah Samir, Salsaby Mohamed Ibrahim, Olfat Gamil Shaker, and Geraldine Mohamed Ahmed. "Evaluation of postoperative pain in infected root canals after using double antibiotic paste versus calcium hydroxide as intra-canal medication: A randomized controlled trial." F1000Research 7 (November 8, 2018): 1768. http://dx.doi.org/10.12688/f1000research.16820.1.

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Background: Postoperative pain is defined as pain of any degree after initiation of endodontic treatment either intra-appointment or post-obturation and is considered an undesirable occurrence for both patient and dentist. It was suggested that bacterial injury is probably the major cause of pain. Intra-canal medicaments are widely used to kill any bacteria surviving after instrumentation and irrigation. The aim of this study was to assess the ability of double antibiotic paste versus calcium hydroxide used as intra-canal medication in reducing postoperative pain. Methods: 36 patients with single rooted necrotic premolars with apical periodontitis were randomly assigned into two groups according to the intra-canal medication used: calcium hydroxide group (CH) and double antibiotic paste group (DAP). Preoperative pain was recorded using numerical rating scale. After isolation, access cavity was performed followed by chemico-mechanical preparation using rotary Race files with 2.5% sodium hypochlorite irrigation. Subsequently, intra-canal medication was placed and postoperative pain was recorded at 6, 12, 24 and 48 hours postoperatively. Results: There was no statistically significant difference between both groups. Both groups resulted in an increase in median pain value from preoperative to 6 hours postoperative, followed by gradual decrease from 6 hours to 12, 24, 48 hours postoperatively with statistically significant difference. When comparing both groups, DAP group showed lower postoperative pain values than CH group at 12 and 24 hours, but this was not statistically significant. Conclusion: The use of intra-canal medication in necrotic teeth with apical periodontitis was efficient in reducing postoperative pain regardless of type of intra-canal medication used. Trial registration: PACTR201605001482394 (Date: 22nd February 2016).

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Shah, Ruchi RaniPurvesh, TapatiManohar Sinhal, NimishaChinmay Shah, PratikSubhas Jais, and KrupaliDhirubhai Hadwani. "Comparative evaluation of 2% chlorhexidine gel and triple antibiotic paste with calcium hydroxide paste on incidence of interappointment flare-up in diabetic patients: A randomized double-blinded clinical study." Endodontology 29, no. 2 (2017): 136. http://dx.doi.org/10.4103/endo.endo_20_17.

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Khaled Hassan Abd El Bary, Mohamed, Jealan Mohamed El Shafei, and Nehal Nabil Roshdy. "Comparison of the Effect of Calcium Hydroxide Nanoparticles Paste versus Double Antibiotic Paste Used in Regenerative Endodontic Procedure on the Chemical Structure of Radicular Dentin (An In Vitro study)." Acta Scientific Dental Scienecs 3, no. 8 (July 31, 2019): 120–28. http://dx.doi.org/10.31080/asds.2019.03.0608.

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Sarraf, Pegah, Atoosa Assadi, Nazanin Kiomarsi, Fatemeh Mohammadian, Arsalan Assadi, and Ahmad Reza Shamshiri. "Effect of Intracanal Medicaments on Pull-Out Bond Strength of Fiber Post Cemented with a Self-Adhesive System." European Journal of Dentistry 13, no. 03 (July 2019): 420–25. http://dx.doi.org/10.1055/s-0039-1694313.

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Abstract Objectives This study aimed to assess the effect of four intracanal medicaments on pull-out bond strength of fiber posts. Materials and Methods A total of 65 single-rooted, single-canal teeth were selected and decoronated. Root canals were prepared and after rinsing were randomly divided into five groups (n = 13). G1: calcium hydroxide (CH), G2: CH plus chlorhexidine (CH+CHX), G3: triple antibiotic paste (TAP), G4: double antibiotic paste (DAP) were applied in the canals in the four groups. The control group (G5) received no medicament. After 4 weeks, the medicaments were rinsed off and the canals were filled with gutta-percha. Post space was then prepared in root canals for the placement of glass fiber posts and self-adhesive cement (Panavia F2). After cementation, they were subjected to pull-out bond strength test. Statistical Analysis Data were statistically analyzed using one-way analysis of variance and Tukey test.Results The pull-out bond strength values were significantly different in the groups (p < 0.001). The highest values of bond strength were seen in G2, G1, and G3 (359.97 ± 81.26, 333.79 ± 98.96, 309.27 ± 78.07), respectively. There was no significant difference between G4 and G5 (p = 0.75). Conclusion The results showed that CH, CH+CHX, and TAP enhanced the pull-out bond strength of fiber post to root canal wall as compared to the control group.

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Kim, Ki Wan, Ghaeth H. Yassen, Ygal Ehrlich, Kenneth Spolnik, Jeffrey A. Platt, and L. Jack Windsor. "The effects of radicular dentine treated with double antibiotic paste and ethylenediaminetetraacetic acid on the attachment and proliferation of dental pulp stem cells." Dental Traumatology 31, no. 5 (June 2, 2015): 374–79. http://dx.doi.org/10.1111/edt.12181.

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Omaia, Mohamed, Maged Negm, Yousra Nashaat, Nehal Nabil, and Amal Othman. "The effect of triple antibiotic paste as an intracanal medication with an anti-inflammatory drug on post-operative pain of asymptomatic uniradicular necrotic teeth: a double blind randomized clinical trial." F1000Research 8 (September 25, 2019): 1687. http://dx.doi.org/10.12688/f1000research.19699.1.

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Background: Flare-ups may occur after root canal treatment which consist of acute exacerbation of asymptomatic pulpal and/or periradicular pathologic condition. The causative factors of interappointment pain include mechanical, chemical or microbial irritation to the pulp or periradicular tissues. The potential role of microorganisms in interappointment pain is why the success of endodontic treatment depends on complete eradication of microorganisms capable of causing an intraradicular or extraradicular infection. This can be achieved by mechanical cleaning and shaping, in conjunction with irrigation and antibacterial agents. The aim of this study was to assess the ability of triple antibiotic paste with the anti-inflammatory drug diclofenac potassium versus calcium hydroxide used as an intra-canal medication in reducing post-operative pain. Methods: 84 patients with asymptomatic uniradicular necrotic teeth were randomly assigned into two groups according to the intra-canal medication used: calcium hydroxide group (CH) and triple antibiotic paste with diclofenac potassium group (TAPC). In the first treatment session, intracoronal cavity preparation was performed after rubber dam isolation followed by chemo-mechanical preparation using rotary Protaper Universal files with saline irrigation followed by intra-canal medication placement then postoperative pain was assessed at 24, 48 and 72 hours postoperatively using Visual Analogue Scale (VAS). In the second treatment session, intracanal medications were removed by irrigation using saline followed by obturation. Results: Both intracanal medicaments resulted in a statistically significant decrease in mean pain value from 24 to 48 and 72 hours postoperatively. While when comparing both groups, TAPC intracanal medication showed less post-operative pain compared to that of the CH group at 24, 48 and 72 hours with a statistically significant difference at 48 hours only. Conclusion: Both intracanal medicaments were efficient in reducing post-operative pain in asymptomatic uniradicular necrotic teeth. Trial registration: Clinicaltrial.gov NCT02907489, 20/09/2016.

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Omaia, Mohamed, Maged Negm, Yousra Nashaat, Nehal Nabil, and Amal Othman. "The effect of triple antibiotic paste as an intracanal medication with an anti-inflammatory drug on post-operative pain of asymptomatic uniradicular necrotic teeth: a double blind randomized clinical trial." F1000Research 8 (June 23, 2021): 1687. http://dx.doi.org/10.12688/f1000research.19699.2.

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Background: Flare-ups may occur after root canal treatment which consist of acute exacerbation of asymptomatic pulpal and/or periradicular pathologic condition. The causative factors of interappointment pain include mechanical, chemical or microbial irritation to the pulp or periradicular tissues. The potential role of microorganisms in interappointment pain is why the success of endodontic treatment depends on complete eradication of microorganisms capable of causing an intraradicular or extraradicular infection. This can be achieved by mechanical cleaning and shaping, in conjunction with irrigation and antibacterial agents. The aim of this study was to assess the ability of triple antibiotic paste with the anti-inflammatory drug diclofenac potassium versus calcium hydroxide used as an intra-canal medication in reducing post-operative pain. Methods: 84 patients with asymptomatic uniradicular necrotic teeth were randomly assigned into two groups according to the intra-canal medication used: calcium hydroxide group (CH) and triple antibiotic paste with diclofenac potassium group (TAPC). In the first treatment session, intracoronal cavity preparation was performed after rubber dam isolation followed by chemo-mechanical preparation using rotary Protaper Universal files with saline irrigation followed by intra-canal medication placement then postoperative pain was assessed at 24, 48 and 72 hours postoperatively using Visual Analogue Scale (VAS). In the second treatment session, intracanal medications were removed by irrigation using saline followed by obturation. Results: Both intracanal medicaments resulted in a statistically significant decrease in mean pain value from 24 to 48 and 72 hours postoperatively. While when comparing both groups, TAPC intracanal medication showed less post-operative pain compared to that of the CH group at 24, 48 and 72 hours with a statistically significant difference at 48 hours only. Conclusion: Both intracanal medicaments were efficient in reducing post-operative pain in asymptomatic uniradicular necrotic teeth. Trial registration: Clinicaltrial.gov NCT02907489, 20/09/2016.

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Yaman Seirawan, Mohammad, Kinda layous, Mohammad Kinan Seirawan, and Mazen Doumani. "Removal of double antibiotic paste and calcium hydroxide from simulated models of regenerative endodontic procedures using several protocols of irrigation: in-vitro comparison study." Journal of Stomatology 74, no. 1 (2021): 1–8. http://dx.doi.org/10.5114/jos.2021.104690.

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Bantawa, Shikha, Navin Agrawal, Mannu Vikram, Vimmi Singh, Ashok Ayer, Arbind Rai, and Sushmita Shrestha. "Management of Traumatic Inflammatory External Root Resorption." Journal of College of Medical Sciences-Nepal 15, no. 1 (March 14, 2019): 71–74. http://dx.doi.org/10.3126/jcmsn.v15i1.22238.

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Inflammatory external root resorption is one of the major complications after traumatic dental injury. It is characterized by the loss of mineralized dental tissue which may, ultimately, result in loss of the tooth. However, with appropriate treatment, prognosis for these teeth may be greatly improved, by preventing or arresting resorption. This is a case report of an 18-year-old male patient presented with root canal treated maxillary central incisors associated with pain; with history of trauma. Radiographic examination revealed periradicular lesion and associated pathologic resorption of the apical region of the root with respect to 11 and calcification of the root canal with inadequate obturation with respect to 21. After removal of the root canal filling, 11 was disinfected with intracanal double antibiotic paste. After 2 weeks, antibiotic dressing was removed, and apical third was sealed with mineral trioxide aggregate (MTA). Canal was obturated with custom-fit gutta-percha and accessory cones with AH plus sealer and restoration was done with composite resin. Retreatment was also done with respect to 21 and obturated with custom-fit gutta-percha. Both teeth were restored with E-max crown. No clinical symptoms were apparent, significant osseous healing of the periradicular region was observed with arrest of external root resorption with respect to 11 and no periapical changes were apparent with respect to 21 on subsequent follow-up.

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Nashaat, yousra. "Evaluation of the Antibacterial efficacy of newly formulated Nano Triple Antibiotic paste with Nano Anti-inflammatory drug as a root canal medicament. (A double blind randomized clinical trial)." Egyptian Dental Journal 66, no. 4 (October 1, 2020): 2815–24. http://dx.doi.org/10.21608/edj.2020.41856.1245.

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Said Abd El Hamid Taie, Hasnaa, Nehal Nabil Roshdy, and Saied Mohamed Abd El Aziz. "Assessment of the Effect of Calcium Hydroxide and Double Antibiotic Paste as Root Canal Medications on the Bond Strength of AH Plus Root Canal Sealer: An in Vitro Study." Acta Scientific Dental Scienecs 3, no. 12 (November 27, 2019): 144–50. http://dx.doi.org/10.31080/asds.2019.03.0716.

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El-Baz, Alaa, and Geraldine Ahmed. "COMPARISON OF THE EFFECT OF CALCIUM HYDROXIDE AND THE MODIFIED TRIPLE ANTIBIOTIC PASTE AS INTRACANAL MEDICATION ON THE ELIMINATION OF ENTEROCOCCUS FAECALIS IN RETREATMENT CASES A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL." Egyptian Dental Journal 63, no. 4 (October 1, 2017): 3995–4004. http://dx.doi.org/10.21608/edj.2017.76466.

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El-Baz, Alaa, and Geraldine Ahmed. "COMPARISON OF THE EFFECT OF CALCIUM HYDROXIDE AND THE MODIFIED TRIPLE ANTIBIOTIC PASTE AS INTRACANAL MEDICATION ON THE ELIMINATION OF ENTEROCOCCUS FAECALIS IN RETREATMENT CASES. A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL." Egyptian Dental Journal 63, no. 4 (October 1, 2017): 3683–92. http://dx.doi.org/10.21608/edj.2017.92784.

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El-Din, Shaimaa Nasr, Magdy M. Ali, and Reham Hassan. "Comparison of Apically Extruded Debris Associated with Different Irrigation Techniques after Removal of Intracanal Medicaments." Open Access Macedonian Journal of Medical Sciences 9, no. D (August 20, 2021): 120–25. http://dx.doi.org/10.3889/oamjms.2021.6094.

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This study aimed to compare the effect of XP-endo Finisher file (XPF), passive ultrasonic irrigation (PUI) and conventional irrigation technique using side-vented needle (SVN) on the amount of apically extruded debris after the removal of calcium hydroxide Ca(OH)2 and double antibiotic paste (DAP). Materials and Methods: Sixty extracted human mandibular premolars were used. After decronation, all canals were prepared up to the ProTaper Next X4 file (Dentsply Maillefer, Ballaigues, Switzerland). After dryness, teeth were randomly assigned into 2 groups (n=30) according to the Type of intracanal medication used; Ca(OH)2 and DAP then incubated at 37 °C and 100% humidity. After one week, Samples in each group were randomly assigned to 3 subgroups (n=10) according to the method used for medicament removal: XPF, PUI and SVN. Debris extruded during the removal procedure were collected into pre-weighed Eppendorf tubes then left to dry in an incubator at 37°C for 15 days. The amount of extruded debris was assessed with an analytical balance and calculated by subtracting the initial weight from the final weight of the tube. Data were statistically analyzed using Kruskal-Wallis and Mann-Whitney U test. Results: there was no statistically significant difference regarding the amount of apically extruded debris after using the three irrigation techniques in removal of both Ca(OH)2 and DAP (P-value = 0.141, Effect size = 0.160) and (P-value = 0.237, Effect size = 0.073) respectively. Conclusions: Neither XPF nor PUI increase the risk of intracanal medicament extrusion beyond the apex.

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Verma, Rohan, Benjamin I. Fischer, Richard L. Gregory, and Ghaeth H. Yassen. "The Radiopacity and Antimicrobial Properties of Different Radiopaque Double Antibiotic Pastes Used in Regenerative Endodontics." Journal of Endodontics 44, no. 9 (September 2018): 1376–80. http://dx.doi.org/10.1016/j.joen.2018.06.010.

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Sabrah, Alaa H. A., Ghaeth H. Yassen, Kenneth J. Spolnik, Anderson T. Hara, Jeffrey A. Platt, and Richard L. Gregory. "Evaluation of Residual Antibacterial Effect of Human Radicular Dentin Treated with Triple and Double Antibiotic Pastes." Journal of Endodontics 41, no. 7 (July 2015): 1081–84. http://dx.doi.org/10.1016/j.joen.2015.03.001.

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Poorni, Saravanan, Manali Ramakrishnan Srinivasan, Dasrathan Duraivel, Lodd Mahendra, and S. Premkumari. "Treatment outcome with a revascularization protocol using double and triple antibiotic pastes in immature necrotic teeth – A double blinded randomized control clinical trial." Journal of Pierre Fauchard Academy (India Section) 31, no. 1 (March 2017): 1–8. http://dx.doi.org/10.1016/j.jpfa.2016.12.002.

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Sabrah, Alaa H. A., Ghaeth H. Yassen, Wai-Ching Liu, W. Scott Goebel, Richard L. Gregory, and Jeffrey A. Platt. "The effect of diluted triple and double antibiotic pastes on dental pulp stem cells and established Enterococcus faecalis biofilm." Clinical Oral Investigations 19, no. 8 (February 19, 2015): 2059–66. http://dx.doi.org/10.1007/s00784-015-1423-6.

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Arslan, Hakan, Merve Akcay, Ismail Davut Capar, Hüseyin Ertas, Evren Ok, and Banu Uysal. "Efficacy of Needle Irrigation, EndoActivator, and Photon-initiated Photoacoustic Streaming Technique on Removal of Double and Triple Antibiotic Pastes." Journal of Endodontics 40, no. 9 (September 2014): 1439–42. http://dx.doi.org/10.1016/j.joen.2014.02.013.

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Wu, Jennifer L., Patrick W. McIntyre, Jung Min Hong, Ghaeth H. Yassen, and Angela Bruzzaniti. "Effects of radiopaque double antibiotic pastes on the proliferation, alkaline phosphatase activity and mineral deposition of dental pulp stem cells." Archives of Oral Biology 117 (September 2020): 104764. http://dx.doi.org/10.1016/j.archoralbio.2020.104764.

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Yaghmoor, Rayan B., Jeffrey A. Platt, Kenneth J. Spolnik, Tien Min Gabriel Chu, and Ghaeth H. Yassen. "Effect of Hydrogel-Based Antibiotic Intracanal Medicaments on Push-Out Bond Strength." European Journal of Dentistry 14, no. 04 (July 29, 2020): 575–83. http://dx.doi.org/10.1055/s-0040-1713956.

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Abstract Objective This study aimed to evaluate the effects of typical clinical concentration (1,000 mg/mL), low concentration (1 mg/mL) triple antibiotic pastes (TAP), and double antibiotic pastes (DAP) on the bond strength between various root cements and radicular dentin. Materials and Methods Intact single-rooted human teeth (n = 144) were horizontally decoronated and canals instrumented. The roots were treated for 4 weeks with Ca(OH)2, 1,000 mg/mL of TAP or DAP, and 1 mg/mL of TAP or DAP. Untreated roots served as a control. After treatment, the medicaments were irrigated and each group was divided into three subgroups receiving MTA, Biodentine, or Endosequence putty cement. After 2 weeks, coronal and middle root cylinders were obtained from each root. Push-out bond strength test and failure analysis were performed for all root cylinders. Statistical Analysis Three-way ANOVA, pairwise comparisons and logistic regression were used for statistical analyses. A significance level of 5% was used. Results For MTA applied in the coronal part of the roots, 1 mg/mL DAP and TAP and Ca(OH)2 demonstrated significantly higher bond strength compared with the typical clinical concentration and the control groups. For Biodentine applied coronally in the roots, 1 mg/mL of DAP resulted in significantly higher bond strength than all other groups. For Endosequence putty cement applied coronally in the roots, 1 mg/mL of DAP offered significantly higher bond strength than all groups except for Ca(OH)2. Conclusion The use of 1 mg/mL DAP resulted in significantly higher push-out bond strength compared with the typical clinical concentration of TAP and DAP regardless of the type of the root cement used.

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Akcay, Merve, Hakan Arslan, Hüseyin Sinan Topcuoglu, and Oznur Tuncay. "Effect of Calcium Hydroxide and Double and Triple Antibiotic Pastes on the Bond Strength of Epoxy Resin–based Sealer to Root Canal Dentin." Journal of Endodontics 40, no. 10 (October 2014): 1663–67. http://dx.doi.org/10.1016/j.joen.2014.05.006.

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Gokturk, Hakan, Emre Bayram, Huda Melike Bayram, Tugrul Aslan, and Yakup Ustun. "Effect of double antibiotic and calcium hydroxide pastes on dislodgement resistance of an epoxy resin-based and two calcium silicate-based root canal sealers." Clinical Oral Investigations 21, no. 4 (June 10, 2016): 1277–82. http://dx.doi.org/10.1007/s00784-016-1877-1.

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Gonçalves, Gabriela Sumie Yaguinuma, Tayna Natsumi Takakura, Anderson Catelan, Rosalinda Tanuri Zaninotto Venturim, Carolina dos Santos Santinoni, and Christine Men Martins. "Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (April 20, 2020): 535–40. http://dx.doi.org/10.21270/archi.v9i6.4814.

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Introdução: Lesões endoperiodontais são lesões originadas de produtos inflamatórios encontrados tanto em periodonto quanto em polpa. Tais lesões podem se originar devido a uma infecção pulpar ou periodontal. Visando o prognóstico favorável, é imprescindível o conhecimento da etiologia, realização do correto diagnóstico e elaboração do plano de tratamento que envolve o tratamento endodôntico precedido do tratamento periodontal. Objetivo: O propósito do presente trabalho foi de relatar um caso clínico de lesão endoperiodontal e o tratamento realizado. Relato de caso clínico: Paciente gênero feminino, 51 anos, compareceu à clínica com uma fístula na região do dente 46, procedeu-se com exame radiográfico, rastreamento de fístula, testes endodônticos e avaliação periodontal. Foi diagnosticada lesão endoperiodontal. Executou-se, então, o tratamento endodôntico em sessões múltiplas, utilizando hidróxido de cálcio como medicação intracanal e o tratamento periodontal concomitante; finalizou-se endodontia obturando-se os canais radiculares. Conclusão: Observou-se, no controle, que a associação de tratamentos foi eficaz e houve melhora significativa do quadro, constatando-se silêncio clínico e sucesso do tratamento. Realizar o tratamento conservador a despeito da exodontia foi a melhor escolha para a paciente. Descritores: Endodontia; Periodontia; Polpa Dentária; Periodonto. Referências Sunitha VR, Emmadi P, Namasivayam A, Thyegarajan R, Rajaraman V. The periodontal - endodontic continuum A review. J Conserv Dent. 2008;11(2):54-62. Betancourt P, Elgueta R, Fuentes R. Treatment of endo-periodontal lesion using leukocyte-platelet-rich fibrin - a case report. Colomb Med. 2017;48(4):204-7. Lopes HP, Siqueira JF. Endodontia: Biologia e Técnica. Rio de Janeiro: Medsi-Guanabara Koogan; 2015. Lindhe J, Karring T, Lang NP. Tratado de periodontia clínica e implantologia oral. Rio de Janeiro: Guanabara Koogan; 2010. Anand V, Govila V, Gulati M. Endo-perio lesion part II (the treatment) - a review. 2012;3(1):10-6. Rotstein I, Simon JH. Diagnosis, prognosis and decision-making in the treatment of combined periodontal-endodontic lesions. J Periodontol. 2004;34:165-203. Parolia A, Gait TC, Porto ICCM, Mala K. Endo-perio lesion: a dilemma from 19th until 21st century. J Interdisp Dent. 2013;3(1):2-11. Kim E, Song JS, Jung IY, Lee SJ, Kim S. Prospective clinical study evaluating endodontic microsurgery outcomes for cases with lesions of endodontic origin compared with cases with lesions of combined periodontal-endodontic origin. J Endod. 2008;34(5):546-51. Heasman PA. An endodontic conundrum: the association between pulpal infection and periodontal disease. Br Dent J. 2014;216(6):275-9. Schmidt JC, Walter C, Amato M, Weiger R. Treatment of periodontal-endodontic lesions--a systematic review. J Clin Periodontol. 2014; 41(8):779-90. Jivoinovici R, Suciu I, Dimitriu B, Perlea P, Bartok R, Malita M, Ionescu C. Endo-periodontal lesion--endodontic approach. J Med Life. 2014;7(4):542-44. Estrela C. Endodontia laboratorial e clínica, Série Abeno: Odontologia Essencial - Parte Clínica. São Paulo: Artes Médicas; 2013. Vera J, Siqueira JF Jr, Ricucci D, Loghin S, Fernández N, Flores B et al. One-versus two-visit endodontic treatment of teeth with apical periodontitis: a histobacteriologic study. J Endod. 2012;38(8):1040-52. Mohammadi Z, Dummer PMH. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Inter Endod J. 2011;44(8):697-730. Batista VES, Olian DA, Mori GG. Diffusion of hydroxyl ions from calcium hydroxide and aloe vera pastes. Braz Dent J. 2014;25(3):212-16. Pereira TC, da Silva Munhoz Vasconcelos LR, Graeff MSZ, Ribeiro MCM, Duarte MAH, de Andrade FB. Intratubular decontamination ability and physicochemical properties of calcium hydroxidepastes. Clin Oral Investig. 2019;23(3):1253-62. Andolfatto C, da Silva GF, Cornélio AL, Guerreiro-Tanomaru JM, Tanomaru-Filho M, Faria G, Bonetti-Filho I, Cerri PS. Biocompatibility of intracanal medications based on calcium hydroxide. ISRN Dent. 2012;2012:904963. Duque TM, Prado M, Herrera DR, Gomes BPFA. Periodontal and endodontic infectious/inflammatory profile in primary periodontal lesions with secondary endodontic involvement after a calcium hydroxide-based intracanal medication. Clin Oral Investig. 2019;23(1):53-63. Kim D, Kim E. Antimicrobial effect of calcium hydroxide as an intracanal medicament in root canal treatment: a literature review - Part I. In vitro studies. Restor Dent Endod. 2014; 39(4):241-52. Adl A, Motamedifar M, Shams MS, Mirzaie A. Clinical investigation of the effect of calcium hydroxide intracanal dressing on bacterial lipopolysaccharide reduction from infected root canals. Aust Endod J. 2015;41(1):12-6. Hilton TJ, Ferracane JL, Mancl L; Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NWP). Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial. J Dent Res. 2013;92(7 Suppl):16S-22S. Labban N, Yassen GH, Windsor LJ, Platt JA. The direct cytotoxic effects of medicaments used in endodontic regeneration on human dental pulp cells. Dent Traumatol. 2014;30(6):429-34. McIntyre PW, Wu JL, Kolte R, Zhang R, Gregory RL, Bruzzaniti A, Yassen GH. The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system. Clin Oral Investig. 2019;23(3):1051-59. Bergenholtz, G., Hasselgren, G. Endodontics and periodontics. In: Lindhe, K., Karring, T., Lang, N. Clinical periodontology and implant dentistry. Copenhagen:Munksgaard; 2015. Harrington GW, Steiner DR, Ammons WF. The periodontal-endodontic controversy. Periodontol 2000. 2002;30:123-30. Fernandes LA, Martins TM, Almeida JM, Nagata MJ, Theodoro LH, Garcia VG, Bosco AF. Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats. J Appl Oral Sci. 2010;18(6):635-40. Storrer CM, Bordin GM, Pereira TT. How to diagnose and treat periodontal endodontic lesions? 2012;9(4):427-33. Verma PK, Srivastava R, Gupta KK, Srivastava A. Combined endodontic periodontal lesions: A clinical dilema. J Interdiscip Dent. 2011;1(2):119-24. Oh SL, Fouad AF, Park SH. Treatment strategy for guided tissue regeneration in combined endodontic-periodontal lesions: case report and review. J Endod. 2009;35(10):1331-36. Malli R, Lele P, Vishakha. Guided tissue regeneration in communicating periodontal and endodontic lesions - a hope for the hopeless. J Indian Soc Periodontol. 2011;15(4):410-13. Ghezzi C, Virzì M, Schupbach P, Broccaioli A, Simion M. Treatment of combined endodontic-periodontic lesions using guided tissue regeneration: clinical case and histology. Int J Periodontics Restorative Dent. 2012;32(4):433-9. Sun J, Liu Q. [Bio-Oss collagen bone grafting in the treatment of endodontic-periodontic lesion]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29(9):1905-6. Sharma R, Hegde V, Siddharth M, Hegde R, Manchanda G, Agarwal P. Endodontic-periodontal microsurgery for combined endodontic-periodontal lesions: An overview. J Conserv Dent. 2014;17(6):510-16. Li Y, Wang X, Xu J, Zhou X, Xie K. [The clinical study on the use of diode laser irradiation in the treatment of periodontal-endodontic combined lesions]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2012;30(2):161-64, 168. Narang S, Narang A, Gupta R. A sequential approach in treatment of perio-endo lesion. J Indian Soc Periodontol. 2011;15(2):177-80. Pereira AL, Orzechowski PR, Filho SB, Cortelli JR. Subepithelial connective tissue graft: an alternative application for treating endoperiodontal lesions. Gen Dent. 2013;61(2):50-3. Yoneda M, Motooka N, Naito T, Maeda K, Hirofuji T. Resolution of furcation bone loss after non-surgical root canal treatment: application of a peptidase-detection kit for treatment of type I endoperiodontal lesion. J Oral Sci. 2005; 47(3):143-47. Shenoy N, Shenoy A. Endo-perio lesions: diagnosis and clinical considerations. Indian J Dent Res. 2010;21(4):579-85. Gerritsen AE, Allen PF, Witter DJ, Bronkhorst EM, Creugers NH. Tooth loss and oral health-related quality of life: a systematic review and meta-analysis. Health Qual Life Outcomes. 2010;8:126.

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Gupta, Ravi, Radhika Kewalramani, and Dishant Patel. "Spectrophotometric assessment of Tooth discoloration induced by various Antibiotic pastes." Research Journal of Pharmacy and Technology, April 29, 2021, 1979–81. http://dx.doi.org/10.52711/0974-360x.2021.00350.

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Title: Spectrophotometric assessment of tooth discoloration induced by various Antibiotic pastes. Aim: To evaluate tooth discoloration induced by various Antibiotic pastes using spectrophotometer. Materials and Methods: Sixty extracted upper front tooth were selected for the study. Access opening was done and root canal of each tooth was instrumented with hand files. The tooth were then randomly divided into 3 groups: Group A (Triple antibiotic paste: Ciprofloxacin+ Metronidazole+Minocycline), Group B (Modified Triple antibiotic paste: Ciprofloxacin+ Metronidazole+ Clindamycin) and Group C (Double antibiotic paste: Ciprofloxacin+ Metronidazole). In all the groups, medicaments were only applied inside the root canals of the teeth and access cavity was sealed with cotton pellet and temporary restoration. Spectrophotometric readings were obtained from buccal surface of the teeth immediately after placing the medicaments (Baseline data) and at 1 week and after 2 months. Based on spectrophotometric readings at different time interval, ∆E was then calculated. Data were analyzed using 2-way (ANOVA) tests. Results: The maximum color change (ΔE) was observed at 2 months with Triple antibiotic paste (p < 0.0001) followed by Modified Triple antibiotic paste. No significant color change was noted with Double antibiotic paste. Conclusion: Antibiotic paste should be used judiciously inside the root canals of teeth to eliminate chronic root canal infection due to risk of tooth discoloration. Double antibiotic paste is a more promising option.

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Naidu, Sudhakar, Mahendravarma Nadimpalli, Gowtam Dev Dondapati, Thangi Sowjanya, Srivalli Podili, and Mattapudi Basavaiah Babu. "Comparative Antimicrobiotic Efficacy Test of Triple Antibiotic Paste, Double Antibiotic Paste with Fungicide and Calcium Hydroxide with Chitosan as Vehicle against Enterococcus faecalis: An In vitro Study." Journal of Pharmaceutical Research International, January 27, 2021, 13–22. http://dx.doi.org/10.9734/jpri/2020/v32i4431076.

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Introduction: This present research aimed to assess the in vitro antimicrobial efficacy of triple antibiotic paste and calcium hydroxide with two different vehicles against Enterococcus faecalis (E. faecalis). Materials and Methodology: An agar well diffusion assay was used to determine the experimental medicaments' efficacy against E. faecalis. Medicaments were divided into six groups, which includes Triple antibiotic powder (TAP) with saline or chitosan, Double antibiotic powder with fungicide (DAP 1) with saline or Chitosan, and calcium hydroxide with saline or Chitosan. These medicines were tested in an agar well diffusion test for three days, i.e., 1,4,7 days. The diameters of growth inhibition zones were recorded and compared for each group were tested in an agar well diffusion test for three days, i.e., 1,4,7 days. The diameters of growth inhibition zones were recorded and compared for each group. These medicaments were evaluated for three days an agar well diffusion test, i.e., on 1,4,7 days. The inhibition zones diameters for each group were recorded and compared — the differences between groups analyzed by Kruskal-Wallis and Mann-Whitney U tests. Results: The largest inhibition zones were observed for the triple antibiotic powder with chitosan and the smallest for Ca(OH)2 with saline. As days progress, they produced lesser antibacterial effects in all groups. Conclusion: Triple antibiotic paste and Chitosan were more effective in eliminating microorganisms than calcium hydroxide and DAP 1.

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Devaraj, Sharmila, Nithya Jagannathan, and Prasanna Neelakantan. "Antibiofilm efficacy of photoactivated curcumin, triple and double antibiotic paste, 2% chlorhexidine and calcium hydroxide against Enterococcus fecalis in vitro." Scientific Reports 6, no. 1 (April 21, 2016). http://dx.doi.org/10.1038/srep24797.

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"ASSESSMENT OF EFFICACY OF PHOTOACTIVATED DISINFECTION VERSUS DOUBLE ANTIBIOTIC PASTE DISINFECTION IN REGENERATION OF IMMATURE INFECTED TEETH. A COMPARATIVE VIVO STUDY." Ain Shams Dental Journal 18, no. 2 (June 1, 2020): 103–10. http://dx.doi.org/10.21608/asdj.2020.164460.

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"Reduction of Pain and Bacterial Presence by using Double and Triple Antibiotic Pastes in Symptomatic Apical Periodontitis." Journal of Liaquat University of Medical & Health Sciences 18, no. 02 (June 30, 2019): 129–35. http://dx.doi.org/10.22442/jlumhs.191820615.

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