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Journal articles on the topic 'Double-blinded placebo controlled food challenge'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ballmer-Weber, Barbara K., Brunello Wüthrich, Andrea Wangorsch, Kay Fötisch, Friedrich Altmann, and Stefan Vieths. "Carrot allergy: Double-blinded, placebo-controlled food challenge and identification of allergens." Journal of Allergy and Clinical Immunology 108, no. 2 (2001): 301–7. http://dx.doi.org/10.1067/mai.2001.116430.

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2

KLEIN, G. "Double-blind, placebo-controlled food challenge." Journal of Allergy and Clinical Immunology 85, no. 1 (1990): 139. http://dx.doi.org/10.1016/0091-6749(90)90238-y.

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3

Fiocchi, Alessandro, Gian Paolo Mirri, Isabella Santini, Luca Bernardo, Fabrizio Ottoboni, and Enrica Riva. "Exercise-induced anaphylaxis after food contaminant ingestion in double-blinded, placebo-controlled, food-exercise challenge." Journal of Allergy and Clinical Immunology 100, no. 3 (1997): 424–25. http://dx.doi.org/10.1016/s0091-6749(97)70258-6.

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4

ONORATO, J., N. MERLAND, C. TERRAL, F. MICHEL, and J. BOUSQUET. "Placebo-controlled double-blind food challenge in asthma." Journal of Allergy and Clinical Immunology 78, no. 6 (1986): 1139–46. http://dx.doi.org/10.1016/0091-6749(86)90263-0.

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5

Skamstrup Hansen, K., H. Vestergaard, P. Stahl Skov, et al. "Double-blind, placebo-controlled food challenge with apple." Allergy 56, no. 2 (2001): 109–17. http://dx.doi.org/10.1034/j.1398-9995.2001.056002109.x.

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6

Andrews, Timothy. "A Comparison of Double-Blind, Placebo-Controlled Food Challenge and Open Food Challenge." Pediatrics 154, Supplement 4 (2024): S23—S24. https://doi.org/10.1542/peds.2024-069114ib.

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7

IV, Charles F. Schuler, Malika Gupta, and Georgiana M. Sanders. "Immunoglobulin E‐mediated food allergy diagnosis and differential diagnosis." Journal of Food Allergy 2, no. 1 (2020): 26–30. http://dx.doi.org/10.2500/jfa.2020.2.200019.

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Food allergies consist of aberrant immunologic, typically immunoglobulin E mediated, reactions that involve food proteins. A clinical history with regard to the suspected food, temporal associations, the duration of symptoms, characteristic symptom complex, and reproducibility in some cases is the key to making an accurate diagnosis. The differential diagnosis includes, for example, other immunologic adverse food reactions, nonimmunologic adverse food reactions, and reactions that involve nonfood items. Skin and blood immunoglobulin E testing for the suspected food antigen can aid the diagnosi

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8

Ahrens, B., B. Niggemann, U. Wahn, and K. Beyer. "Positive reactions to placebo in children undergoing double-blind, placebo-controlled food challenge." Clinical & Experimental Allergy 44, no. 4 (2014): 572–78. http://dx.doi.org/10.1111/cea.12284.

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9

Huijbers, Geertje B., Ann A. M. Colen, Jeannette J. Niestijl Jansen, Alwine F. M. Kardinaal, Berber J. Vlieg-Boerstra, and Ben P. M. Martens. "Masking foods for food challenge: Practical aspects of masking foods for a double-blind, placebo-controlled food challenge." Journal of the American Dietetic Association 94, no. 6 (1994): 645–49. http://dx.doi.org/10.1016/0002-8223(94)90163-5.

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10

Hansen, Tine K., Lars K. Poulsen, Per Stahl Skov, et al. "A randomized, double-blinded, placebo-controlled oral challenge study to evaluate the allergenicity of commercial, food-grade fish gelatin." Food and Chemical Toxicology 42, no. 12 (2004): 2037–44. http://dx.doi.org/10.1016/j.fct.2004.08.008.

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11

Čelakovská, Jarmila, Květuše Ettlerová, Karel Ettler, Jaroslava Vaněčková, and Josef Bukač. "Evaluation of Cow’s Milk Allergy in a Large Group of Adolescent and Adult Patients with Atopic Dermatitis." Acta Medica (Hradec Kralove, Czech Republic) 55, no. 3 (2012): 125–29. http://dx.doi.org/10.14712/18059694.2015.49.

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Few studies concerning the occurrence of cow’s milk allergy with the use of double-blind, placebo controlled food challenge test in adolescents and adult patients suffering from atopic dermatitis exist. Aim: To evaluate the occurrence of cow’s milk allergy in adolescents and adults suffering from atopic dermatitis. Method: Altogether 179 persons suffering from atopic dermatitis were included in the study: 51 men and 128 women entered the study with the average age of 26.2 (s.d. 9.5 years). Complete dermatological and allergological examinations were performed. Results: The positive results in

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12

Ortolani, Claudio, Barbara K. Ballmer-Weber, Kirsten Skamstrup Hansen, et al. "Hazelnut allergy: A double-blind, placebo-controlled food challenge multicenter study." Journal of Allergy and Clinical Immunology 105, no. 3 (2000): 577–81. http://dx.doi.org/10.1067/mai.2000.103052.

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13

Alemán, A., Santiago Quirce, J. Carnés, et al. "Kiwi fruit allergy: A double-blind, placebo-controlled, food challenge study." Journal of Allergy and Clinical Immunology 109, no. 1 (2002): S218—S219. http://dx.doi.org/10.1016/s0091-6749(02)81792-4.

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14

Burks, A. Wesley, Lynn Christie, Karen A. Althage, Julie M. Kesler, and Gregory S. Allgood. "Randomized, Double-Blind, Placebo-Controlled, Food Allergy Challenge to Olestra Snacks." Regulatory Toxicology and Pharmacology 34, no. 2 (2001): 178–81. http://dx.doi.org/10.1006/rtph.2001.1488.

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15

Vlieg-Boerstra, B. J., S. van der Heide, J. Kukler, et al. "Analysis of Placebo Reactions in Double-Blind, Placebo-Controlled Food Challenge Tests in Children." Journal of Allergy and Clinical Immunology 117, no. 2 (2006): S51. http://dx.doi.org/10.1016/j.jaci.2005.12.208.

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16

Catlett, John B. "A Critical Look at the Double-Blind Placebo-Controlled Food Challenge Test." Allergy and Asthma Proceedings 18, no. 6 (1997): 369. http://dx.doi.org/10.2500/108854197778558043.

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17

Lüttkopf, Dirk, Barbara K. Ballmer-Weber, Brunello Wüthrich, and Stefan Vieths. "Celery allergens in patients with positive double-blind placebo-controlled food challenge." Journal of Allergy and Clinical Immunology 106, no. 2 (2000): 390–99. http://dx.doi.org/10.1067/mai.2000.108711.

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18

Hansen, K. Skamstrup, B. K. Ballmer-Weber, D. Luttkopf, et al. "Roasted hazelnuts - allergenic activity evaluated by double-blind, placebo-controlled food challenge." Allergy 58, no. 2 (2003): 132–38. http://dx.doi.org/10.1034/j.1398-9995.2003.23959.x.

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19

Bingol, Aysen, Dilara Kocacik Uygun, Serkan Filiz, and Olcay Yegin. "Banana Allergy In Children Evaluated Using Double Blind Placebo Controlled Food Challenge." Journal of Allergy and Clinical Immunology 133, no. 2 (2014): AB210. http://dx.doi.org/10.1016/j.jaci.2013.12.752.

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20

Vlieg-Boerstra, Berber J., Charles M. A. Bijleveld, Sicco van der Heide, et al. "Development and validation of challenge materials for double-blind, placebo-controlled food challenges in children☆." Journal of Allergy and Clinical Immunology 113, no. 2 (2004): 341–46. http://dx.doi.org/10.1016/j.jaci.2003.10.039.

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21

Čelakovská, Jarmila, Květuše Ettlerová, Karel Ettler, Jaroslava Vaněčková, and Josef Bukač. "The Effect of Wheat Allergy on the Course of Atopic Eczema in Patients over 14 Years of Age." Acta Medica (Hradec Kralove, Czech Republic) 54, no. 4 (2011): 157–62. http://dx.doi.org/10.14712/18059694.2016.41.

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Few studies concerning the importance of wheat allergy affecting the course of atopic eczema in adolescents and adult patients exist. Aim: The evaluation if wheat allergy can deteriorate the course of atopic eczema. Follow-up of patients with confirmed food allergy to wheat. Method: Altogether 179 persons suffering from atopic eczema were included in the study: 51 men and 128 women entered the study with an average age of 26.2 (s.d. 9.5 years) Dermatological and allergological examinations were performed, including skin prick tests, atopy patch tests, and specific serum IgE for wheat, open exp

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22

Wang, De Yun, Bruce R. Gordon, Yiong Huak Chan, and Kian Hian Yeoh. "Potential non–immunoglobulin E–mediated food allergies: Comparison of open challenge and double-blind placebo-controlled food challenge." Otolaryngology–Head and Neck Surgery 137, no. 5 (2007): 803–9. http://dx.doi.org/10.1016/j.otohns.2007.06.714.

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23

Lester, Mitchell R. "Cross-reactivity in Fish Allergy: A Double-blind, Placebo-Controlled Food Challenge Trial." Pediatrics 142, Supplement 4 (2018): S237.1—S237. http://dx.doi.org/10.1542/peds.2018-2420uu.

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24

Ke, Danbing, Bruce Mazer, Duncan Lejtenyi, et al. "Double-blind, Placebo-controlled Food Challenge Is Essential In Primary Hazelnut Allergy Diagnosis." Journal of Allergy and Clinical Immunology 145, no. 2 (2020): AB230. http://dx.doi.org/10.1016/j.jaci.2019.12.200.

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25

Allan Bock, S., Hugh A. Sampson, Fred M. Atkins, et al. "Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: A manual." Journal of Allergy and Clinical Immunology 82, no. 6 (1988): 986–97. http://dx.doi.org/10.1016/0091-6749(88)90135-2.

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26

Sørensen, Martin, Annette Kuehn, E. N. Clare Mills, et al. "Cross-reactivity in fish allergy: A double-blind, placebo-controlled food-challenge trial." Journal of Allergy and Clinical Immunology 140, no. 4 (2017): 1170–72. http://dx.doi.org/10.1016/j.jaci.2017.03.043.

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27

BINDSLEVJENSEN, C. "153 Double-blind, placebo-controlled food challenge (DBPCFC) in the diagnosis of food allergy and food intolerance." Journal of Allergy and Clinical Immunology 87, no. 1 (1991): 177. http://dx.doi.org/10.1016/0091-6749(91)91436-w.

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28

Gabrielli, Sofianne, Bruce Mazer, Danbing Ke, et al. "Factors associated with tolerating double-blind placebo-controlled food challenge in school-aged children." Journal of Allergy and Clinical Immunology 147, no. 2 (2021): AB87. http://dx.doi.org/10.1016/j.jaci.2020.12.332.

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29

Merras-Salmio, Laura, Anna S. Pelkonen, Kaija-Leena Kolho, Mikael Kuitunen та Mika J. Mäkelä. "Cowʼs Milk–Associated Gastrointestinal Symptoms Evaluated Using the Double-Blind, Placebo-Controlled Food Challenge". Journal of Pediatric Gastroenterology and Nutrition 57, № 3 (2013): 281–86. http://dx.doi.org/10.1097/mpg.0b013e3182993fe0.

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30

Vandekerckhove, Marjolein, Bart Van Droogenbroeck, Marc De Loose, et al. "A Novel Double-Blind, Placebo-Controlled Food Challenge Matrix for Milk and Raw Egg." International Archives of Allergy and Immunology 179, no. 1 (2019): 1–9. http://dx.doi.org/10.1159/000494622.

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31

van der Valk, Johanna P. M., Roy Gerth van Wijk, Anthony E. J. Dubois, et al. "Multicentre Double-Blind Placebo-Controlled Food Challenge Study in Children Sensitised to Cashew Nut." PLOS ONE 11, no. 3 (2016): e0151055. http://dx.doi.org/10.1371/journal.pone.0151055.

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32

Chinchilli, Vernon M., Laura Fisher, and Timothy J. Craig. "Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge." Journal of Allergy and Clinical Immunology 115, no. 3 (2005): 592–97. http://dx.doi.org/10.1016/j.jaci.2005.01.008.

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33

Pelikan, Zdenek. "Late Type of Bronchial Response to Milk Ingestion Challenge: A Comparison of Open and Double-Blind Challenge." Journal of Allergy 2012 (November 3, 2012): 1–11. http://dx.doi.org/10.1155/2012/515267.

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Background. In some asthmatics the food allergy, for example, to milk, can participate in their bronchial complaints. The role of food allergy should be confirmed definitively by food ingestion challenge performed by an open challenge with natural foods (OFICH) or by a double-blind placebo-controlled food challenge (DBPCFC). Objectives. To investigate the diagnostic value of these techniques for confirmation of a suspected milk allergy in bronchial asthma patients. Methods. In 54 asthmatics with a positive history and/or positive skin tests for milk the 54 OFICH, and DBPCFC, were performed in

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34

Flokstra - de Blok, B. M. J., G. N. van der Meulen, J. N. G. Oude Elberink, et al. "Quality-of-Life of Food Allergic Adults Improves after Double-Blind Placebo-Controlled Food Challenge: Preliminary results." Journal of Allergy and Clinical Immunology 123, no. 2 (2009): S143. http://dx.doi.org/10.1016/j.jaci.2008.12.532.

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35

NIGGEMANN, SIELAFF, BEYER, BINDER, and WAHN. "Outcome of double-blind, placebo-controlled food challenge tests in 107 children with atopic dermatitis." Clinical & Experimental Allergy 29, no. 1 (1999): 91–96. http://dx.doi.org/10.1046/j.1365-2222.1999.00454.x.

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36

Ballmer-Weber, Barbara K., Thomas Holzhauser, Joseph Scibilia, et al. "Clinical characteristics of soybean allergy in Europe: A double-blind, placebo-controlled food challenge study." Journal of Allergy and Clinical Immunology 119, no. 6 (2007): 1489–96. http://dx.doi.org/10.1016/j.jaci.2007.01.049.

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37

Vatn, M. H., L. A. Grimstad, L. Thorsen, et al. "Adverse Reaction to Food: Assessment by Double-Blind Placebo-Controlled Food Challenge and Clinical, Psychosomatic and Immunologic Analysis." Digestion 56, no. 5 (1995): 421–28. http://dx.doi.org/10.1159/000201270.

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38

Smith, Steven R., John E. Blundell, Colleen Burns, et al. "Pramlintide treatment reduces 24-h caloric intake and meal sizes and improves control of eating in obese subjects: a 6-wk translational research study." American Journal of Physiology-Endocrinology and Metabolism 293, no. 2 (2007): E620—E627. http://dx.doi.org/10.1152/ajpendo.00217.2007.

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Evidence from rodent studies indicates that the β-cell-derived neurohormone amylin exerts multiple effects on eating behavior, including reductions in meal size, intake of highly palatable foods, and stress-induced sucrose consumption. To assess the effect of amylin agonism on human eating behavior we conducted a randomized, blinded, placebo-controlled, multicenter study investigating the effects of the amylin analog pramlintide on body weight, 24-h caloric intake, portion sizes, “fast food” intake, and perceived control of eating in 88 obese subjects. After a 2-day placebo lead-in, subjects s

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39

Vlieg-Boerstra, B. J., C. M. Bijleveld, S. van der Heide, et al. "Development and validation of materials for double-blind placebo-controlled food challenge (DBPCFC) tests in children." Journal of Allergy and Clinical Immunology 111, no. 2 (2003): S352. http://dx.doi.org/10.1016/s0091-6749(03)81296-4.

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40

Sanchez-Garcia, S., C. Gamez, E. Lopez, et al. "Allergy To Shrimp: A Double Blind, Placebo-controlled, Food Challenge Study And Allergens Implicated In Spain." Journal of Allergy and Clinical Immunology 123, no. 2 (2009): S23. http://dx.doi.org/10.1016/j.jaci.2008.12.102.

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41

Barone, Michele, Eugenio Gemello, Maria Teresa Viggiani, et al. "Evaluation of Non-Celiac Gluten Sensitivity in Patients with Previous Diagnosis of Irritable Bowel Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial." Nutrients 12, no. 3 (2020): 705. http://dx.doi.org/10.3390/nu12030705.

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Background. To date, there is no reliable marker for the diagnosis of non-celiac gluten sensitivity (NCGS), which benefits from a gluten-free diet (GFD). This condition is characterized by functional gastrointestinal symptoms similar to those occurring in the course of irritable bowel syndrome (IBS). However, IBS has a higher prevalence, and often benefits from the administration of a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet. The overlap of symptoms between these two pathologies has led to an overestimation of self-made diagnosis NCGS. Aims. To

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42

Tang, Helen, Lauren Bohannon, Meagan Lew, et al. "Randomised, double-blind, placebo-controlled trial of Probiotics To Eliminate COVID-19 Transmission in Exposed Household Contacts (PROTECT-EHC): a clinical trial protocol." BMJ Open 11, no. 5 (2021): e047069. http://dx.doi.org/10.1136/bmjopen-2020-047069.

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IntroductionThe COVID-19 pandemic has proven to be an unprecedented challenge to worldwide health, and strategies to mitigate the spread and severity of COVID-19 infection are urgently needed. Emerging evidence suggests that the composition of the gut microbiome and modification of microbial ecology via probiotics can affect susceptibility to a wide range of infections, including respiratory tract infections. In this study, we aim to evaluate the effects of the probiotic Lactobacillus rhamnosus GG (LGG) versus placebo on COVID-19 infection status and the gut microbiome in subjects with a house

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43

Assa’ad, Amal H. "Oral food challenges." Journal of Food Allergy 2, no. 1 (2020): 31–34. http://dx.doi.org/10.2500/jfa.2020.2.200008.

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Oral food challenge (OFC) is a procedure that is conducted most commonly by allergist/immunologists in their office or in food allergy centers to confirm a food allergy or to confirm tolerance to the food. The procedure as conducted in clinical practice is mostly open food challenge and, in research, a double-blind, placebo controlled food challenge. OFC has associated risks that can be minimized by having the challenges conducted by trained personnel who are prepared to treat allergic reactions and who have rescue medications available. However, OFCs have tremendous benefits to the patients a

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44

Carr, Warner, Brian P. Vickery, Rezi Zawadzki, Noelle M. Griffin, Daniel C. Adelman, and Edwin Kim. "Estimating the Probability of Tolerating Each Challenge Dose of Peanut Protein at Exit Double-Blind, Placebo-Controlled Food Challenge: Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial (PALISADE) of AR101." Journal of Allergy and Clinical Immunology 143, no. 2 (2019): AB262. http://dx.doi.org/10.1016/j.jaci.2018.12.801.

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45

Accomando, S., F. Serraino, R. Antona, et al. "855 Double Blind Placebo Controlled Food Challenge Useful to Disconfirm Over Estimated Diagnosis of Cmpa in Children." Pediatric Research 68 (November 2010): 429. http://dx.doi.org/10.1203/00006450-201011001-00855.

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46

Pastorello, Elide A., Stefan Vieths, Valerio Pravettoni, et al. "Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results." Journal of Allergy and Clinical Immunology 109, no. 3 (2002): 563–70. http://dx.doi.org/10.1067/mai.2002.121946.

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47

Accomando, S., F. Serraino, R. Antona, et al. "PA83 DOUBLE BLIND PLACEBO CONTROLLED FOOD CHALLENGE USEFUL TO DISCONFIRM OVER ESTIMATED DIAGNOSIS OF CMPA IN CHILDREN." Digestive and Liver Disease 42 (October 2010): S376. http://dx.doi.org/10.1016/s1590-8658(10)60677-9.

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48

Morisset, M., D. A. Moneret-Vautrin, F. Maadi, et al. "Prospective study of mustard allergy: first study with double-blind placebo-controlled food challenge trials (24 cases)." Allergy 58, no. 4 (2003): 295–99. http://dx.doi.org/10.1034/j.1398-9995.2003.00074.x.

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49

Stefan, Matthew, Matthew Sharp, Raad Gheith, et al. "L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial." Nutrients 13, no. 10 (2021): 3432. http://dx.doi.org/10.3390/nu13103432.

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L-carnitine tartrate has been shown to improve relatively short-term recovery among athletes. However, there is a lack of research on the longer-term effects in the general population. Objective: The primary objectives of this randomized double-blind, placebo-controlled trial were to evaluate the effects of daily L-carnitine tartrate supplementation for 5 weeks on recovery and fatigue. Method: In this study, eighty participants, 21- to 65-years-old, were recruited. Participants were split into two groups of forty participants each, a placebo, and a L-carnitine Tartrate group. Seventy-three par

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50

Čelakovská, Jarmila, Jaroslava Vaněčková, Květuše Ettlerová, Karel Ettler, and Josef Bukač. "The Role of Atopy Patch Test in Diagnosis of Food Allergy in Atopic Eczema/Dermatitis Syndrom in Patients over 14 Years of Age." Acta Medica (Hradec Kralove, Czech Republic) 53, no. 2 (2010): 101–8. http://dx.doi.org/10.14712/18059694.2016.67.

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Few studies concerning the importance of food allergy in adolescents and adult patients with atopic eczema exist. The atopy patch tests with food have mostly been studied in infants and children since food allergy plays a role especially in this age group. Aim: The evaluation of the contribution of atopy patch tests in the diagnostic work-up of food allergy (to wheat, cow milk, peanuts, soya and eggs) in the patients with atopic eczema older than 14 years of age. Method: 120 patients were examined in the study in the diagnostic work-up of food allergy – 86 women and 34 men, the mean age 26.5 (

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