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Journal articles on the topic 'DOVA'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Cursaru, Gabriela. "Stamatia Dova, Greek Heroes in and out of Hades." Mythos, no. 10 (December 1, 2016): 248–51. http://dx.doi.org/10.4000/mythos.545.

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Drewniak, Krystyna, and Mark Fielding. "VTE prophylaxis admission assessment full cycle audit and QI project." BJPsych Open 7, S1 (2021): S77. http://dx.doi.org/10.1192/bjo.2021.244.

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AimsThe aim of the project was to assess completion rates for the VTE prophylaxis assessment for patients admitted to Dova Unit, Dane Garth. Another aim of the project was to identify areas for improvement and changes which could increase compliance rates.MethodIn the first cycle of the audit 20 randomly selected patients admitted to Dova Unit, Dane Garth between June and December 2020 were identified and included in the project. Data were then collected from the online patient record system Rio and analysed using an excel spreadsheet.In the second cycle of the audit 10 randomly selected patie

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Kah, A., and D. Dörnemann. "Glutamic Acid-1-semialdehyde, a Hypothetical Intermediate in the Biosynthesis of 5-Aminolevulinic Acid." Zeitschrift für Naturforschung C 42, no. 3 (1987): 209–14. http://dx.doi.org/10.1515/znc-1987-0306.

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Whether glutamate-1-semialdehyde (G-1-SA) or 4,5 dioxovalerate (DOVA) is the intermediate between glutamate and ALA in the C-5 tetrapyrrol pathway is still a matter of controversy. Since no data characterizing G-1-SA are available it is not possible either to identify G-1-SA as intermediate or a precursor of ALA. Therefore, attempts were made to establish a chemical synthesis of this compound. Two strategies were developed: starting from protected glutamate via an open chain mechanism or from the cyclic compound pyroglutamic acid or derivatives. None of the attempts were successful. Both appr

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Garda, Zoltán, Tamara Kócs, István Bányai та ін. "Complexes of Bifunctional DO3A-N-(α-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies". Molecules 26, № 16 (2021): 4956. http://dx.doi.org/10.3390/molecules26164956.

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The thermodynamic, kinetic, and structural properties of Ln3+ complexes with the bifunctional DO3A-ACE4− ligand and its amide derivative DO3A-BACE4− (modelling the case where DO3A-ACE4− ligand binds to vector molecules) have been studied in order to confirm the usefulness of the corresponding Gd3+ complexes as relaxation labels of targeted MRI contrast agents. The stability constants of the Mg2+ and Ca2+ complexes of DO3A-ACE4− and DO3A-BACE4− complexes are lower than for DOTA4− and DO3A3−, while the Zn2+ and Cu2+ complexes have similar and higher stability than for DOTA4− and DO3A3− complexes

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Bernal, Jorge, F. Javier Sánchez, Gloria Fernández-Esparrach, Debora Gil, Cristina Rodríguez, and Fernando Vilariño. "WM-DOVA maps for accurate polyp highlighting in colonoscopy: Validation vs. saliency maps from physicians." Computerized Medical Imaging and Graphics 43 (July 2015): 99–111. http://dx.doi.org/10.1016/j.compmedimag.2015.02.007.

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Chen, Jinbo, Chengcheng Lu, Jiacheng Ni, Xiaochen Guo, Patrick Girard, and Yuanqing Cheng. "DOVA PRO: A Dynamic Overwriting Voltage Adjustment Technique for STT-MRAM L1 Cache Considering Dielectric Breakdown Effect." IEEE Transactions on Very Large Scale Integration (VLSI) Systems 29, no. 7 (2021): 1325–34. http://dx.doi.org/10.1109/tvlsi.2021.3073415.

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7

Ke, Xian-Sheng, Juan Tang, Zi-Shu Yang та Jun-Long Zhang. "β-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents". Journal of Porphyrins and Phthalocyanines 18, № 10n11 (2014): 950–59. http://dx.doi.org/10.1142/s1088424614500758.

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Synthesis of two bimodal imaging agents consist of a hydrophobic zinc(II) tetrapentafluorophenylporpholactol core and a β-substituted hydrophilic Gd ( III ) DO3A (ZnLGd539) or DOTA (ZnLGd595) like moiety has been described (DO3A = 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). Through β-conjugation approach, the absorption at deep red region increases compared to traditional conjugation methods at meso-position. More importantly, these new complexes possess largely improved ionic relaxitivites relative to the sole Gd ( III

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Lye, Suzanne. "S. Dova Greek Heroes in and out of Hades. Lanham MD: Lexington Books, 2012, Pp. 242. $70. 9780739144978." Journal of Hellenic Studies 134 (2014): 174–75. http://dx.doi.org/10.1017/s0075426914001657.

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Del Giorgio, Elena, and Thomas Just Sørensen. "HOCl Responsive Lanthanide Complexes Using Hydroquinone Caging Units." Molecules 25, no. 8 (2020): 1959. http://dx.doi.org/10.3390/molecules25081959.

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Redox biology is still looking for tools to monitor redox potential in cellular biology and, despite a large and sustained effort, reliable molecular probes have yet to emerge. In contrast, molecular probes for reactive oxygen and nitrogen have been widely explored. In this manuscript, three kinetically inert lanthanide complexes that selectively react with hypochlorous acid are prepared and characterized. The design is based on 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A) and 1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (DO2A) ligands appended with one or two redox active hy

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Štulanović, Muharem. "MEVLUD IZMEĐU LIJEPOG OBIČAJA (SUNNETUN HASENETUN) I ZABRANJENE NOVOTARIJE (BIDA'TUN SEJJIETUN)." Zbornik radova Islamskog pedagoškog fakulteta u Bihaću 8, no. 8 (2016): 79–116. http://dx.doi.org/10.52535/27441695.2016.8.79-116.

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Svake godine u tradiciji muslimana mjesec rebiul-evvel se posveti pamćenju i sjećanju na Muhammeda, a.s., prigodnim programima ili tkzv. Mevludima. Svake godine dolaskom mjeseca rebiu’l-evvela, u kojem je rođen Allahov Poslanik, a.s., nanovo se aktualizira i pravno šerijatski spor oko pitanja obilježavanja i slavljenja rođendana Muhammeda, a.s., organizovanjem proslave Mevluda, kojeg ortodoksna, puritanistička ulema drži zabranjenom, ružnom novotarijom i inovacijom u vjeri (bida'tun sejjie), koju se ljudi uzakonili, inovirali kao dan praznikovanja slijedeći običaje drugih, kao što su kršćani,

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Lattuada, Luciano, Giovanni B. Giovenzana, Fabio Travagin, and Luca Biondi. "Synthesis of Two Novel Mixed Bifunctional Chelating Agents: DO2AP(tBu)4 and DO3AP(tBu)4." Synlett 31, no. 13 (2020): 1291–94. http://dx.doi.org/10.1055/s-0040-1707893.

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A convenient synthesis of two novel macrocyclic bifunctional chelating agents (BFCAs), formally derived from the well-known ligands DO3A and DOTA by selective replacement of one carboxymethyl side arm with a phosphonomethyl residue, is reported.

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12

Meurs, Wim van. "Wer sind die Moldawier? Rumänismus versus Moldowanismus in Historiographie und Schulbüchern der Republik Mol-dova, 1991–2006 by Stefan Ihrig." Ab Imperio 2008, no. 2 (2008): 458–61. http://dx.doi.org/10.1353/imp.2008.0070.

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13

Xu, Suxia, Qingyun Huang, Chunsong Lin, et al. "Transcriptome comparison reveals candidate genes responsible for the betalain-/anthocyanidin-production in bougainvilleas." Functional Plant Biology 43, no. 3 (2016): 278. http://dx.doi.org/10.1071/fp15246.

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The occurrence of betalains and anthocyanins is mutually exclusive, which is a curious phenomenon in the plant kingdom, and the biochemical mechanisms for this restriction are unknown. In the present study, we performed transcriptome analysis of two betalain-producing species, red Bougainvillea glabra Choisy. ‘Sanderiana’ (R) and white B. glabra ‘Alba’ (W) by transcriptome sequencing. In total, we obtained 69 692 (Red) and 60 727 (White) genes with an average length of 665 and 728 bp respectively. Out of 3106 significantly differentially-expressed genes (71%), 1003 were R-specific (32%), and 1

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Park, Mina, Ho Sun Lee, Jun-Jae Choi, et al. "Diverse Patterns of Perilymphatic Space Enhancement in the Rat Inner Ear after Intratympanic Injection of Two Different Types of Gadolinium: A 9.4-Tesla Magnetic Resonance Study." Audiology and Neurotology 20, no. 2 (2015): 112–16. http://dx.doi.org/10.1159/000368666.

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Objective: To compare the quality of perilymphatic enhancement in the rat inner ear after intratympanic injection of two types of gadolinium with a 9.4-tesla micro-MRI. Materials and Methods: Gadolinium was injected into the middle ear in 6 Sprague-Dawley rats via the transtympanic route. The left ear was injected with Gd-DO3A-butrol first, and then the right ear was injected with Gd-DOTA. MR images of the inner ear were acquired 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, and 4 h after intratympanic (IT) injection using an Agilent MRI system 9.4T/160/AS. The normalized signal intensity was quantitatively a

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15

Al-Samkari, Hanny, Fei Song, Elizabeth M. Van Cott, David J. Kuter, and Rachel P. Rosovsky. "Evaluation of the Prothrombin Fragment 1.2 in Patients with COVID-19." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-134605.

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Introduction: Coronavirus disease 2019 (COVID-19) may cause a hypercoagulable state. The D-dimer is frequently elevated in COVID-19, but other markers of coagulation activation, including the prothrombin fragment 1.2 (PF1.2) are poorly described. Given the near universal D-dimer elevation in critically ill patients with COVID-19, the PF1.2 may be a more specific marker to identify thrombotic complications. Methods: We studied hospitalized adults with COVID-19 and PF1.2 measurement performed at any point during hospitalization. We evaluated the relationship between PF1.2 and synchronously measu

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Mantha, Simon, Andrew Dunbar, Kelly L. Bolton, et al. "Machine Learning for Prediction of Cancer-Associated Venous Thromboembolism." Blood 136, Supplement 1 (2020): 37. http://dx.doi.org/10.1182/blood-2020-138579.

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Background: Several clinical prediction scores have been designed to assess the risk of cancer-associated thrombosis (CAT). The most commonly used in current clinical practice is the Khorana score, however it is applicable only to patients prior to initiation of chemotherapy. We now apply machine learning with clinical, demographic, and genomics parameters to predict CAT events. Methods: The random survival forest (RSF) ensemble learning method was selected to illustrate a machine approach to CAT prediction. The cohort consisted of 14,223 individuals with a solid tumor malignancy and MSK IMPAC

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Cheloff, Abraham Z., David J. Kuter, and Hanny Al-Samkari. "Serum Complement Levels in Immune Thrombocytopenia: Characterization and Relation to Clinical Features." Blood 134, Supplement_1 (2019): 1087. http://dx.doi.org/10.1182/blood-2019-125341.

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Introduction : Complement activation contributes to platelet destruction in immune thrombocytopenia (ITP). Autoantibodies bound to platelets fix complement (Naiaoui et al. 2011) and ITP platelets have increased cell surface-bound C3 and C4 (Kurata et al. 1985). Despite this known pathophysiology there is very little published data describing serum complement levels in ITP patients and no data describing a possible relation of complement levels to disease characteristics. Therapeutics targeting the complement system are now emerging for the treatment of ITP, including an ongoing clinical trial

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Al-Samkari, Hanny, Raj S. Kasthuri, Hasan A. Albitar, et al. "An International Multicenter Study of Intravenous Bevacizumab for the Treatment of Chronic Bleeding and Anemia in Hereditary Hemorrhagic Telangiectasia: The Inhibit-Bleed Study." Blood 134, Supplement_1 (2019): 1060. http://dx.doi.org/10.1182/blood-2019-129418.

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Introduction : Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is a rare hereditary multisystem vascular disease of disordered angiogenesis. Pathologic elevations in vascular endothelial growth factor (VEGF) result in fragile, abnormal vessels in nasal and gastrointestinal (GI) mucosa causing recurrent epistaxis, chronic GI bleeding, and anemia that is often transfusion-dependent. Bevacizumab is a monoclonal IgG1 antibody that neutralizes circulating VEGF and is a potential targeted anti-angiogenic treatment in HHT, which has no FDA-approved therapy. Data for use of intr

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Mantha, Simon, Justin Jee, Gerald A. Soff, and Melissa S. Pessin. "Prediction of COVID-19 Mortality in Patients with Cancer." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-138576.

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Background: Coronavirus disease 2019 (COVID-19) is associated with an increased mortality rate in patients with cancer. Machine learning approaches have been used successfully to predict mortality in infected patients from the general population. We aimed to devise an algorithm to estimate the risk of death in the first 45 days after COVID-19 diagnosis for patients with cancer. Methods: As a first step we used the ensemble learning method random survival forests. Computations were performed with R packages randomForestSRC, ROCR and cvAUC. The cohort consisted of Memorial Sloan Kettering patien

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Bahrenberg, Thorsten, Yin Yang, Daniella Goldfarb, and Akiva Feintuch. "rDEER: A Modified DEER Sequence for Distance Measurements Using Shaped Pulses." Magnetochemistry 5, no. 1 (2019): 20. http://dx.doi.org/10.3390/magnetochemistry5010020.

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The DEER (double electron-electron resonance, also called PELDOR) experiment, which probes the dipolar interaction between two spins and thus reveals distance information, is an important tool for structural studies. In recent years, shaped pump pulses have become a valuable addition to the DEER experiment. Shaped pulses offer an increased excitation bandwidth and the possibility to precisely adjust pulse parameters, which is beneficial especially for demanding biological samples. We have noticed that on our home built W-band spectrometer, the dead-time free 4-pulse DEER sequence with chirped

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Al-Samkari, Hanny, Alexandria Cronin, Donald M. Arnold, Francesco Rodeghiero, and Rachael F. Grace. "Extensive Variability in Platelet Count, Bleeding, and Quality of Life Outcome Measures in Adult and Pediatric Immune Thrombocytopenia: An Appraisal from a Critical Review of the Literature." Blood 136, Supplement 1 (2020): 45–46. http://dx.doi.org/10.1182/blood-2020-138694.

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Introduction: Despite publication of standardized platelet count response definitions by the immune thrombocytopenia (ITP) International Working Group (IWG) in 2009, there remains considerable variability in the definition of platelet count outcomes across ITP studies. Moreover, there is no widely-accepted bleeding scale, health-related quality of life (HRQoL) inventories, or definition of remission for use in ITP patients, all critical outcome measures not addressed in the IWG Report. This heterogeneity makes comparison of response rates and outcomes between studies challenging. Therefore, to

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Nwafor, Felix I., Ugochukwu Igwe, Chidi Ogbonna, Godswill Ajuziogu, and Maria O. Nwosu. "WOOD ANATOMICAL STUDIES REVEAL TAXONOMIC RELATIONSHIPS, ENVIRONMENTAL INFLUENCE AND PULP POTENTIAL IN FOUR TAXA OF Mussaenda (RUBIACEAE) GROWN IN NIGERIA." Journal of Experimental Biology and Agricultural Sciences 9, no. 1 (2021): 102–7. http://dx.doi.org/10.18006/2021.9(1).102.107.

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Current study was carried out to assess the taxonomic, ecological significance, and paper making potential of four taxa of Mussaenda L. (Rubiaceae) viz., M. elegans, M. erythrophylla, M. philippica var. aurorae, and M. ‘Dona Aurora’ through wood anatomical studies. Each of the taxa was collected from its natural region of provenance in two different ecological zones (Derived Savanna and Tropical Rainforest) of Nigeria. Observations from different planes of sections were made and wood maceration was carried out for fibre morphology. Absent to scanty paratracheal axial parenchyma, septate fibres

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Nwafor, Felix I., Ugochukwu Igwe, Chidi Ogbonna, Godswill Ajuziogu, and Maria O. Nwosu. "WOOD ANATOMICAL STUDIES REVEAL TAXONOMIC RELATIONSHIPS, ENVIRONMENTAL INFLUENCE AND PULP POTENTIAL IN FOUR TAXA OF Mussaenda (RUBIACEAE) GROWN IN NIGERIA." Journal of Experimental Biology and Agricultural Sciences 9, no. 1 (2021): 100–107. http://dx.doi.org/10.18006/2021.9(1).100.107.

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Current study was carried out to assess the taxonomic, ecological significance, and paper making potential of four taxa of Mussaenda L. (Rubiaceae) viz., M. elegans, M. erythrophylla, M. philippica var. aurorae, and M. ‘Dona Aurora’ through wood anatomical studies. Each of the taxa was collected from its natural region of provenance in two different ecological zones (Derived Savanna and Tropical Rainforest) of Nigeria. Observations from different planes of sections were made and wood maceration was carried out for fibre morphology. Absent to scanty paratracheal axial parenchyma, septate fibres

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Newland, Adrian C., Blanca Sánchez-González, László Rejtő, et al. "Phase 2 Study of Efgartigimod, a Novel FcRn Antagonist, in Adult Patients with Primary Immune Thrombocytopenia." Blood 134, Supplement_1 (2019): 895. http://dx.doi.org/10.1182/blood-2019-128022.

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Background Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder, characterized by a low platelet count (&lt;100×109/L) in the absence of other causes. In most patients, IgG autoantibodies are detected which accelerate platelet clearance, inhibit platelet production, induce platelet apoptosis or complement-dependent lysis, and may alter platelet function, resulting in increased risk of bleeding and impaired quality of life. Efgartigimod is a human IgG1 antibody Fc-fragment, a natural ligand of the neonatal Fc receptor (FcRn), engineered for increased affinity to

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Boyko, V. A., S. V. Levchenko, D. Yu Belash, and A. V. Romanov. "IMPACT OF “LIGNOHUMATE” FERTILIZER ON PRODUCTIVITY INDICATORS AND GRAPES QUALITY IN THE CONDITIONS OF THE REPUBLIC OF CRIMEA." Russian Vine 15 (March 2021): 43–51. http://dx.doi.org/10.32904/2712-8245-2021-15-43-51.

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This article provides the results of study of mineral plant nutrition systems based on the "Lignohumate" fertilizer and assessment of their impact on productivity indicators and grapes quality. 4 and 6-fold treatment sys-tems in conditions of irrigation and without irrigation were studied. Research was carried out during 2018–2020 on grape varieties Moldova and Muscat rosoviy in the condi-tions of the Republic of Crimea. A positive influence of vegetation treatments with the "Lignohumate" fertilizer on yield of variety Moldova was discovered. It increased in irri-gation conditions by 11.6% (4-

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Henarejos-Escudero, Paula, Luis Eduardo Contreras-Llano, José Daniel Lozada-Ramírez, Luz Rayda Gómez-Pando, Francisco García-Carmona, and Fernando Gandía-Herrero. "A dopamine-based biosynthetic pathway produces decarboxylated betalains in Chenopodium quinoa." Plant Physiology 186, no. 3 (2021): 1473–86. http://dx.doi.org/10.1093/plphys/kiab158.

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Abstract Betalains are the nitrogenous pigments that replace anthocyanins in the plant order Caryophyllales. Here, we describe unconventional decarboxylated betalains in quinoa (Chenopodium quinoa) grains. Decarboxylated betalains are derived from a previously unconsidered activity of the 4,5-DOPA-extradiol-dioxygenase enzyme (DODA), which has been identified as the key enzymatic step in the established biosynthetic pathway of betalains. Here, dopamine is fully characterized as an alternative substrate of the DODA enzyme able to yield an intermediate and structural unit of plant pigments: 6-de

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Rabrenovic, Milorad, Radomir Matunovic, Violeta Rabrenovic, and Uros Zoranovic. "Hyperbaric medicine: Dilemmas regarding its possibilities." Vojnosanitetski pregled 65, no. 3 (2008): 235–38. http://dx.doi.org/10.2298/vsp0803235r.

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<zakljucak> Napredak u oblasti hiperbaricne medicine sve je ocigledniji, ali njena primena ne sme biti svojina male grupe ljudi, bilo zbog monopola, ili zbog neznanja i nezainteresovanosti drugih. Iako je koriscenje hiperbaricne oksigenacije kao i nabavka hiperbaricnih komora (visemesnih ili jednomesnih) uslovljena velikim finansijskim ulaganjima, korist od njene primene daleko je veca, a toga treba da budu svesni svi koji odlucuju o njoj. U poslednje vreme sve je manje dilema o opravdanosti primene HBOT, a sve vise se otvaraju nova polja moguce primene. Razvoj molekularne medicine stvor

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Kruse, Alexandra, Caroline Kruse, Nancy Potthast, Kelsey Milligan, and James B. Bussel. "Mental Health and Treatment in Patients with Immune Thrombocytopenia (ITP); Data from the Platelet Disorder Support Association (PDSA) Patient Registry." Blood 134, Supplement_1 (2019): 2362. http://dx.doi.org/10.1182/blood-2019-122278.

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Background and Aims Patients with Immune Thrombocytopenia (ITP) may have bleeding because of low platelet counts; many also have reduced quality of life (QoL). Course of therapy can vary by duration and severity of disease but includes steroids and thrombopoietin receptor agonists [TPO-RA]. Both symptoms of ITP and side effects from treatments impact patient QoL, commonly anxiety and fatigue. In 2017, PDSA in collaboration with the National Organization for Rare Diseases launched the ITP Registry to understand patient characteristics, their disease, disease management, and QoL. Here, we descri

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Blinder, Morey, Michael Vredenburg, Wei Tian, Brian Jamieson, and Keith R. McCrae. "Consistent Efficacy Demonstrated By Avatrombopag in Immune Thrombocytopenia (ITP) Regardless of the Number of Lines of Prior ITP Treatment." Blood 136, Supplement 1 (2020): 32–33. http://dx.doi.org/10.1182/blood-2020-136585.

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Background: Clinical management of ITP depends on both disease severity and risk of bleeding. Treatment typically is considered when platelet counts (PC) fall below 30,000/µL, with a target PC of ≥50,000/µL to mitigate the risk of bleeding. The standard-of-care after failure of 1st line therapy (corticosteroids or intravenous immunoglobulin) has been shifting from splenectomy and rituximab, toward an increased use of thrombopoietin receptor agonists (TPO-RAs), as supported by the recent American Society of Hematology guidelines (Neunert 2019). The TPO-RAs eltrombopag (ELT) and romiplostim (ROM

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Leiva, Orly, Olesya Baker, Andrew M. Brunner, et al. "Rates of Thrombotic Events in Hypereosinophilic Syndrome and the Effect of Molecular Aberrations in Thrombotic Risk." Blood 136, Supplement 1 (2020): 14. http://dx.doi.org/10.1182/blood-2020-137311.

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Background: Idiopathic hypereosinophilia and hypereosinophilic syndrome (HES) comprise a rare, heterogeneous group of hematologic disorders characterized by the overproduction of eosinophils leading to tissue eosinophilic infiltration and damage. Hypereosinophilia can be primary - due to a clonal or malignant process - or secondary to a non-clonal process. Primary eosinophilia can be accompanied by clonal markers, such as in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA/B, FGFR1 or PCM1-JAK2, genetic mutations or chromosomal abnormalities leading to a diagnosis of ch

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Song, Andrew B., David J. Kuter, and Hanny Al-Samkari. "Characterization of the Rate, Predictors, and Thrombotic Complications of Thrombocytosis in Iron Deficiency Anemia." Blood 134, Supplement_1 (2019): 959. http://dx.doi.org/10.1182/blood-2019-122359.

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Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia worldwide and is frequently untreated or undertreated (Kesselbaum et al. 2014). The association of thrombocytosis with IDA is well-recognized, with recent work elucidating its underlying physiology (Xavier-Ferrucio et al. 2018). Thrombocytosis in IDA may predispose to thrombotic complications, as described in many case reports. Given that IDA is ubiquitous, even minor increases in thrombotic risk due to thrombocytosis have dramatic public health implications. Data describing the rate, predictors, and risk of thrombot

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Sathe, Claire M., Chester Poon, Debra M. M. Sarasohn, et al. "Development and Baseline Characterization of a Thrombosis Risk Alert Tool: A Quality Assessment Project." Blood 136, Supplement 1 (2020): 18–19. http://dx.doi.org/10.1182/blood-2020-142037.

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Introduction: The Khorana Score (KS) is a validated tool to assess the risk of thrombosis in cancer patients, prior to initiation of chemotherapy. The AVERT and CASSINI studies evaluated prophylactic anticoagulation with apixaban or rivaroxaban for patients with KS of 2 or higher. Both studies demonstrated that while patients were taking prophylactic anticoagulant, the Hazard Ratio of cancer associated thrombosis was approximately 0.4. The NCCN and other societies are now recommending oral anticoagulant prophylaxis should be considered for up to 6 months, for patients with an intermediate or h

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Jain, Shivi, Matthew Wojdyla, Michael Vredenburg, Brian Jamieson, and Terry B. Gernsheimer. "Durability of Initial Platelet Count Response in Patients Treated with Avatrombopag for Immune Thrombocytopenia (ITP): Post-Hoc Results from a Phase 3 Clinical Study." Blood 136, Supplement 1 (2020): 22–23. http://dx.doi.org/10.1182/blood-2020-142764.

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Background: The clinical management of ITP has been evolving. Thrombopoietin receptor agonists (TPO-RAs) have become widely utilized as subsequent treatments, and the 2019 ASH guidelines recommend their use over rituximab to achieve a durable response. TPO-RAs eltrombopag (ELT) and romiplostim (ROMI) have been FDA approved for over a decade with a well demonstrated efficacy profile. ELT, an oral medication, must be administered two hours prior to or four hours after meals containing polyvalent cations such as calcium or magnesium to mitigate clinically relevant effects on the pharmacokinetic p

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Ambrosini, Valentina, Domenico Rubello, Cristina Nanni, Adil Al-Nahhas, and Stefano Fanti. "68Ga-DOTA-peptides versus 18F-DOPA PET for the assessment of NET patients." Nuclear Medicine Communications 29, no. 5 (2008): 415–17. http://dx.doi.org/10.1097/mnm.0b013e3282ffd70d.

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Seto, Stephanie L., Megan E. Barra, Russel J. Roberts, and Rachel P. Rosovsky. "Incidence and Outcomes of Heparin-Induced Thrombocytopenia Associated with a Heparin Shortage at a Large Academic Medical Center." Blood 136, Supplement 1 (2020): 10. http://dx.doi.org/10.1182/blood-2020-141282.

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Heparin-induced thrombocytopenia (HIT) is a life-threatening complication associated with significant morbidity and mortality in hospitalized patients. The 2019 African swine fever outbreak in China resulted in a critical national shortage of porcine-derived heparin products in the United States. As a result, our institution implemented a multitude of mitigation strategies to reduce heparin utilization by &gt;80% and optimize safe and effective alternative therapies. The aim of this study was to determine whether this change in clinical practice impacted the incidence of HIT and associated

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Voráčová, Ivona, Jakub Vaněk, Josef Pasulka, Zora Střelcová, Přemysl Lubal, and Petr Hermann. "Dissociation kinetics study of copper(II) complexes of DO3A, DOTA and its monosubstituted derivatives." Polyhedron 61 (September 2013): 99–104. http://dx.doi.org/10.1016/j.poly.2013.05.042.

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Higbie, Carolyn. "THE HERO'S KATABASIS - (S.) Dova Greek Heroes in and out of Hades. Pp. xiv + 227, ills. Lanham, MD and Plymouth: Lexington Books, 2012. Cased, £44.95, US$70. ISBN: 978-0-7391-4497-8." Classical Review 64, no. 1 (2014): 14–15. http://dx.doi.org/10.1017/s0009840x13002102.

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Bussel, James B., Alexandra Kruse, Caroline Kruse, et al. "The Burden of Disease and IMPACT of Immune Thrombocytopenia (ITP) on Patients: Results from an ITP Survey." Blood 134, Supplement_1 (2019): 1076. http://dx.doi.org/10.1182/blood-2019-131351.

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Background: Immune thrombocytopenia (ITP) is an autoimmune disorder causing reduced platelet counts <100,000/µL, with potential bleeding consequences and reduced quality of life. Treatment is generally reserved for adults with platelet counts <30,000/µL. Methods: ITP patients from the Platelet Disorder Support Association were recruited to complete a one-time cross-sectional survey online. Eligible adults from the United States self-reported that they had been diagnosed with ITP and received at least 1 treatment. Patients completed a 30-45-minute online survey about demographics, diagnos

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Suvin, Darko. "PRISTUP EPISTEMOLOGIJI, KNJIŽEVNOSTI I PJESNIKOVOJ POLITICI." Годишњак Филозофског факултета у Новом Саду 41, no. 1 (2017): 421–40. http://dx.doi.org/10.19090/gff.2016.1.421-440.

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Moja je početna pretpostavka da je shvaćanje ili doxa što smo ga naslijedili od Visokoga modernizma zakazalo tokom, i upravo zbog, postmodernističkog i postfordističkog trijumfa grabljivog kapitalizma. Time je obuhvaćena i masovna zlouporaba modernih nauka u ratovima i osiromašavanju naroda, kao i uništavanje intelektualnih pretpostavki kako praktične ljevice u doba staljinizma, koje se manifestovalo u katastrofama posle 1968. i 1989, tako i pravog slobodoljubivog liberalizma. Ta široka tema zaslužuje zasebnu obradu, premda uz oštro odbacivanje postmodernističke „slabe misli“ napuštanja

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Petrović, Jelena, Djuro Macut, and Dragana Šobić Šaranović. "VIZUALIZACIJA NEUROENDOKRINIH TUMORA METODAMA NUKLEARNE MEDICINE." Medicinski podmladak 71, no. 3 (2020): 1–7. http://dx.doi.org/10.5937/mp71-27009.

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Neuroendokrini tumori (NET) su relativno retki i heterogeni sa vrlo heterogenom kliničkom slikom. Potiču iz senzornih i sekretornih neuroendokrinih ćelija uglavnom unutar plućnog i gastrointestinalnog trakta. Sačinjavaju manje od 2% svih malignih oboljenja. Na osnovu kliničkog ponašanja, histologije i proliferacije, podeljeni su u dobro diferentovane (niski do srednji stepen) i slabo diferentovane (visoki stepen) neuroendokrine tumore. Pripadnost svakoj od ovih kategorija ima uticaj na lečenje i prognozu. Jedino lečenje je operacija. S obzirom da više od 50% pacijenata u vreme postavljanja d

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Kuter, David J., Michael Wajnrajch, Betina Hernandez, Rong Wang, Raul Chertkoff, and Ari Zimran. "Open-Label, Expanded Access Study of Taliglucerase Alfa in Patients with Gaucher Disease Requiring Enzyme Replacement Therapy." Blood 132, Supplement 1 (2018): 3755. http://dx.doi.org/10.1182/blood-2018-99-112660.

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Abstract Taliglucerase alfa, an enzyme replacement therapy (ERT) approved in several countries for the treatment of adult and pediatric patients with Type 1 Gaucher disease, is the first FDA-approved plant cell-expressed recombinant therapeutic protein for humans. PB-06-004 (NCT00962260) was a multicenter, open-label, expanded access study designed to follow the safety of taliglucerase alfa in patients with Gaucher disease who required ERT and who were previously treated with imiglucerase but had a dose reduction or discontinued due to a shortage of imiglucerase. Eligible patients (aged ≥18 ye

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Attia, Doaa, Xuefei Jia, Mailey L. Wilks, et al. "Risk of Recurrent Venous Thromboembolism and Bleeding in Patients with Cancer Associated Thrombosis." Blood 136, Supplement 1 (2020): 18. http://dx.doi.org/10.1182/blood-2020-142805.

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Background: The treatment paradigm for cancer associated thrombosis (CAT) has evolved over recent years from using low molecular weight heparin (LMWH) to direct oral anticoagulants (DOACs). Some randomized trials suggest decreased rates of recurrent venous thromboembolism (VTE) in CAT patients treated with DOACs compared to LMWH but also reported increased rates of bleeding. The Cleveland Clinic Taussig Cancer Center has been treating cancer thrombosis in a centralized CAT clinic since 2014. Here we report our rates of bleeding and recurrent VTE in cancer patients treated with anticoagulation.

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Lubis, Ramadan. "DOSA DAN DIMENSI PSIKOLOGIS YANG TERKANDUNG Di DALAMNYA." JURNAL BIOLOKUS 1, no. 1 (2018): 46. http://dx.doi.org/10.30821/biolokus.v1i1.309.

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<p class="Default">Dosa adalah segala perbuatan yang bertentangan dengan kehendak dan perintah Allah SWT. Sampai disini belum dibedakan besar kecilnya dosa. Abdullah bin Abbas berkata,“ Setiap perbuatan menentang ajaran Islam adalah dosa besar.”, kelalaian dan kekhilapan yang dilakukan manusia ini dapat dianggab sebagai dosa-dosa kecil, namun dosa-dosa kecil ini bila terus-menerus dilakukan maka akan menjadi dosa besar. Tulisan ini mencoba mengungkap serba sedikit tentang perbuatan dosa yang sering dilakukan manusia serta dilihat dimensi psikologis yang terkandung dalam perbuatan dosa te

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Nomay, Usman. "Petuah Bijak Syair Syair Lokal Ternate." PUSAKA 7, no. 1 (2019): 1–22. http://dx.doi.org/10.31969/pusaka.v7i1.238.

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Penelitian ini adalah penelitian kualitatif deskriptif, yang mengidentifikasi petuah bijak dalam masyarakat di Ternate. Dalil moro, dalil tifa, dola bololo, mantra, cum-cum, legenda, rorasa dan tamsil. Syair-syair ini berbentuk sastra atau pantun dan mengandung nilai asimilasi relasi sosial yang sangat signifikan. Bait-demi bait secara keseluruhan menggambarkan keanekaragaman pola pikir dan pola berbuat yang bermartabat. Syair-syair dalam bentuk petuah bijak ini pada esensinya menampilkan sifat humanis dan sifat religius. Secara teknis hal ini melahirkan sebuah falsafah keragaman dan kebersatu

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Barcellona, Pietro. "Elogio del discorso inutile." RUOLO TERAPEUTICO (IL), no. 114 (May 2010): 28–40. http://dx.doi.org/10.3280/rt2010-114003.

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La nostra epoca tecnico-scientifica sembra ossessionata dalla risoluzione di problemi, pratici o teorici che siano. Saggisti, opinionisti e persino filosofi non resistono al richiamo delle sirene. Il dramma č che ai consulenti predicatori che forniscono ricette e soluzioni, fa da contraltare una schiera sempre piů vasta di individui disorientati e incapaci di prendere decisioni autonome. La ricerca della veritŕ, perň, č ben diversa dalla ricerca di rimedi efficaci, perché implica la creazione di un nuovo spazio mentale, dove pensieri ed emozioni si trasformano in nuovi pensieri ed emozioni. Di

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46

Ziomber, Agata, Agnes Machnik, Anke Dahlmann, et al. "Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats." American Journal of Physiology-Renal Physiology 295, no. 6 (2008): F1752—F1763. http://dx.doi.org/10.1152/ajprenal.00531.2007.

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Na+ loading without Cl− fails to increase blood pressure in the DOCA model. We compared the changes in the total body (TB) effective Na+, K+, Cl−, and water (TBW) content as well as in intracellular (ICV) or extracellular (ECV) volume in rats receiving DOCA-NaCl, DOCA-NaHCO3, or DOCA-KHCO3. We divided 42 male rats into 5 groups. Group 1 was untreated, group 2 received 1% NaCl, and groups 3, 4, and 5 were treated with DOCA and received 1% NaCl, 1.44% NaHCO3, or 1.7% KHCO3 to drink. We measured mean arterial blood pressure (MAP) directly after 3 wk. Tissue electrolyte and water content was measu

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Ibarra, F. R., J. Aguirre, S. Nowicki, M. Barontini, E. E. Arrizurieta, and I. Armando. "Demethylation of 3-O-methyldopa in the kidney: a possible source for dopamine in urine." American Journal of Physiology-Renal Physiology 270, no. 5 (1996): F862—F868. http://dx.doi.org/10.1152/ajprenal.1996.270.5.f862.

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The possibility that demethylation of 3-O-methyldopa (OM-dopa) in the kidney could provide a source for dopamine in the urine was explored in male Wistar rats aged 60-90 days, using in vivo and in vitro approaches. The results showed that endogenous OM-dopa is filtered, reabsorbed and extensively metabolized in the kidney. Infusion of OM-dopa into anesthetized rats increased significantly urinary excretion of Na+, dopa, dopamine, and 3,4 dihydroxyphenylacetic acid. Whole kidney homogenates, slices from renal cortex, and microdissected proximal tubules produced significant amounts of both dopa

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Grossman, Ehud, Aaron Hoffman, Ines Armando, Zaid Abassi, Irwin J. Kopin, and David S. Goldstein. "Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats." Clinical Science 83, no. 1 (1992): 65–74. http://dx.doi.org/10.1042/cs0830065.

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1. To determine the sources of dopa (3,4-dihydroxyphenylalanine) in plasma, we measured regional arteriovenous differences, tissue concentrations and urinary excretion of dopa during systemic intravenous infusions of I-[3H]dopa into anaesthetized intact rats and rats pretreated with the sympathetic neurotoxin, 6-hydroxydopamine. 2. In intact rats, large arteriovenous increments in plasma dopa concentrations were noted in the femoral (47%) and adrenal (141%) beds, with a small arterial-portal venous increment (11%), whereas in the kidney there was a substantial (47%) arteriovenous decrement in

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Allen, Lee F., Kavita Aggarwal, Michael Vredenburg, Christine Barnett, Deirdre Mladsi, and Ray Kim. "Cost-Effectiveness of Avatrombopag for the Treatment of Thrombocytopenia in Patients with Chronic Liver Disease." Blood 134, Supplement_1 (2019): 3454. http://dx.doi.org/10.1182/blood-2019-131822.

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Background: Patients with chronic liver disease (CLD) often have severe thrombocytopenia (platelet counts &lt;50,000/mL) that can complicate the invasive diagnostic and therapeutic procedures these patients require as part of their clinical management, due to the increased bleeding risk. Avatrombopag is a thrombopoietin receptor agonist (TPO-RA) that is approved for the treatment of thrombocytopenia in patients with CLD as an alternative to platelet transfusions for patients undergoing a procedure. The aim of this study was to evaluate the relative cost-effectiveness of avatrombopag compar

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Kura, Aminu Umar, Samer Hasan Hussein-Al-Ali, Mohd Zobir Hussein, and Sharida Fakurazi. "Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/104246.

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We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating

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