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1

De Palma, Angelo. "Downstream Process Bottlenecks." Genetic Engineering & Biotechnology News 33, no. 13 (July 2013): 1, 36. http://dx.doi.org/10.1089/gen.33.13.17.

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2

Langer, Eric S. "Alleviating Downstream Process Bottlenecks." Genetic Engineering & Biotechnology News 31, no. 13 (July 2011): 1–49. http://dx.doi.org/10.1089/gen.31.13.18.

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3

Friedl, Anton. "Downstream process options for the ABE fermentation." FEMS Microbiology Letters 363, no. 9 (March 27, 2016): fnw073. http://dx.doi.org/10.1093/femsle/fnw073.

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4

Strube, Jochen, Florian Grote, Jan Pablo Josch, and Reinhard Ditz. "Process Development and Design of Downstream Processes." Chemie Ingenieur Technik 83, no. 7 (June 9, 2011): 1044–65. http://dx.doi.org/10.1002/cite.201100017.

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5

Yee, C. L., K. H. Tan, and K. W. Platts. "Managing ‘downstream’ supply network: A process and tool." International Journal of Production Economics 104, no. 2 (December 2006): 722–35. http://dx.doi.org/10.1016/j.ijpe.2004.10.008.

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6

Hämäläinen, Jari J., Ilpo Järvimäki, Robert Weiss, Jan Dahl, and Stefan Ekbom. "Predictive Planning and Control of a Downstream Process." IFAC Proceedings Volumes 33, no. 10 (June 2000): 575–80. http://dx.doi.org/10.1016/s1474-6670(17)38602-0.

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7

Darnon, E., E. Morin, M. P. Belleville, and G. M. Rios. "Ultrafiltration within downstream processing: some process design considerations." Chemical Engineering and Processing: Process Intensification 42, no. 4 (April 2003): 299–309. http://dx.doi.org/10.1016/s0255-2701(02)00053-3.

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8

AKIYAMA, Juichiro, Le Dinh HONG, and Masaru Meura. "ANALYSIS OF SCOUR PROCESS DOWNSTREAM OF A SLUICE." PROCEEDINGS OF HYDRAULIC ENGINEERING 35 (1991): 489–94. http://dx.doi.org/10.2208/prohe.35.489.

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9

Magalhães, Antonio Irineudo, Júlio Cesar de Carvalho, Jesus David Coral Medina, and Carlos Ricardo Soccol. "Downstream process development in biotechnological itaconic acid manufacturing." Applied Microbiology and Biotechnology 101, no. 1 (November 15, 2016): 1–12. http://dx.doi.org/10.1007/s00253-016-7972-z.

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10

Martínez, Ernesto Acosta, João Batista de Almeida e Silva, Marco Giulietti, and Ana Irene Nápoles Solenzal. "Downstream process for xylitol produced from fermented hydrolysate." Enzyme and Microbial Technology 40, no. 5 (April 2007): 1193–98. http://dx.doi.org/10.1016/j.enzmictec.2006.09.003.

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11

Merten, O. "Bioreactors downstream processing process & reactor modelling bioprocesses." Biochimie 71, no. 9-10 (September 1989): 1109–11. http://dx.doi.org/10.1016/0300-9084(89)90122-3.

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12

Meitz, Andrea, Patrick Sagmeister, Timo Langemann, and Christoph Herwig. "An Integrated Downstream Process Development Strategy along QbD Principles." Bioengineering 1, no. 4 (October 24, 2014): 213–30. http://dx.doi.org/10.3390/bioengineering1040213.

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13

Winkelnkemper, T., and G. Schembecker. "Purification fingerprints for experimentally based systematic downstream process development." Separation and Purification Technology 71, no. 3 (March 10, 2010): 356–66. http://dx.doi.org/10.1016/j.seppur.2009.12.024.

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14

Boswell, John. "Deliberating Downstream: Countering Democratic Distortions in the Policy Process." Perspectives on Politics 14, no. 3 (August 31, 2016): 724–37. http://dx.doi.org/10.1017/s1537592716001146.

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Key theorists and scholars of democracy have focused on understanding and enhancing the institutions and practices that shape decision-making. Indeed, the most influential contemporary normative account—the deliberative version—though increasingly adapted to the complex realities of contemporary politics, retains a tight focus on the conditions of legitimate will formation. This remains the core underpinning of the normative impetus for innovation and reform in contemporary democratic politics. Yet missing from even the adapted deliberative account is detailed consideration of what happens after will formation. I turn here to the policy and administration literature to show how the inescapably attritional and opaque policy process can magnify asymmetries that theorists and scholars of contemporary democracy, chief among them deliberative democrats, ought to be much better attuned to. I argue that in failing to consider these problems adequately, contemporary democratic thinkers, scholars, and reformers risk lending legitimacy to institutions and practices that might sustain the very biases they are mobilized against. As such, I identify institutional innovations and governing practices that can embed aspects of democratic deliberation “downstream” in the policy process in order to counter distortions and rebalance asymmetries. I conclude by calling for theorists, researchers, and reformers to explore the value of these institutions and practices, and to expand the repertoire of governing mechanisms available to counter the distortions that occur through the policy process.
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15

Calluaud, D., L. David, and A. Texier. "Vortex shedding process investigation downstream a surface-mounted block." Journal of Visualization 8, no. 2 (June 2005): 99–108. http://dx.doi.org/10.1007/bf03181652.

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16

Horkoff, Jennifer, Tong Li, Feng-Lin Li, Mattia Salnitri, Evellin Cardoso, Paolo Giorgini, and John Mylopoulos. "Using Goal Models Downstream." International Journal of Information System Modeling and Design 6, no. 2 (April 2015): 1–42. http://dx.doi.org/10.4018/ijismd.2015040101.

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Goal models have proven useful for capturing, understanding, and communicating requirements during early stages of software development. However, the utility of goal models is greatly enhanced when they can be exploited during downstream stages of the requirements analysis process (e.g. requirements elaboration, validation, planning), and can be used as part of the entire system life cycle (e.g., architectural and behavioral process design, coding, testing, monitoring, adaptation, and evolution). In order to better understand the progress that has been made in integrating goal models with downstream system development, the authors ask: what approaches exist that map/integrate/transform goal models to later stage software artifacts? To answer this question, they conduct a systematic survey, producing a roadmap of work summarizing 243 publications. Results include a categorization of the “why?” and “how?” for each approach. Furthermore, they select the 50 most prominent publications, based on citation numbers, in order to perform an in-depth literature review. Findings show that there is a wide variety of proposals with a variety of proposed goal models and targets, covering multiple paradigms, motivated by a variety of purposes. The authors conclude that although much work has been done in this area, the work is fragmented, following multiple separate strands of goal-orientation, and is often still in early stages of maturity.
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17

Herrmann, T., D. Roth, and H. Binz. "FRAMEWORK OF AN AMBIDEXTROUS PROCESS OF IDEA MANAGEMENT SUPPORTING THE DOWNSTREAM PRODUCT DEVELOPMENT PROCESS." Proceedings of the Design Society: DESIGN Conference 1 (May 2020): 587–96. http://dx.doi.org/10.1017/dsd.2020.10.

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AbstractOne challenge within idea management of the front end of the design process is the handling of radical ideas, meaning ideas with a high degree of novelty. Companies are approaching radical and incremental ideas frequently with the same methods, although many reasoned claims exists for treating ideas differently according to the degree of novelty. The paper aims to address the fact that ambidexterity does not play any specific role in the front end. Therefore, a framework of an extended idea process model based on the idea of ambidexterity is shown and initial test results are presented.
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18

Liu, Jiahong, L. T. Fan, Paul Seib, Ferenc Friedler, and Botond Bertok. "Holistic Approach to Process Retrofitting: Application to Downstream Process for Biochemical Production of Organics." Industrial & Engineering Chemistry Research 45, no. 12 (June 2006): 4200–4207. http://dx.doi.org/10.1021/ie051014m.

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19

Gronemeyer, Petra, Reinhard Ditz, and Jochen Strube. "Trends in Upstream and Downstream Process Development for Antibody Manufacturing." Bioengineering 1, no. 4 (October 1, 2014): 188–212. http://dx.doi.org/10.3390/bioengineering1040188.

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20

Misra, N. N., Carl Sullivan, and P. J. Cullen. "Process Analytical Technology (PAT) and Multivariate Methods for Downstream Processes." Current Biochemical Engineering 2, no. 1 (April 13, 2015): 4–16. http://dx.doi.org/10.2174/2213385203666150219231836.

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21

Jungbauer, Alois. "High resolution analytics for process characterization to improve downstream processing." New Biotechnology 29 (September 2012): S10—S11. http://dx.doi.org/10.1016/j.nbt.2012.08.020.

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22

Rathore, Anurag S., and Gautam Kapoor. "Application of process analytical technology for downstream purification of biotherapeutics." Journal of Chemical Technology & Biotechnology 90, no. 2 (June 30, 2014): 228–36. http://dx.doi.org/10.1002/jctb.4447.

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23

Beresford, R. "Downstream ion drift in an electron cyclotron resonance plasma process." Journal of Applied Physics 79, no. 3 (February 1996): 1292–97. http://dx.doi.org/10.1063/1.361024.

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24

Fujimura, Shuzo. "Sodium contamination free ashing process using O2+H2O plasma downstream." Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures 12, no. 4 (July 1994): 2409. http://dx.doi.org/10.1116/1.587773.

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25

Ríos, Sergio D., Carmen M. Torres, Carles Torras, Joan Salvadó, Josep M. Mateo-Sanz, and Laureano Jiménez. "Microalgae-based biodiesel: Economic analysis of downstream process realistic scenarios." Bioresource Technology 136 (May 2013): 617–25. http://dx.doi.org/10.1016/j.biortech.2013.03.046.

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26

Seo, Yeong Hwan, Mina Sung, Bohwa Kim, You-Kwan Oh, Dong Yeon Kim, and Jong-In Han. "Ferric chloride based downstream process for microalgae based biodiesel production." Bioresource Technology 181 (April 2015): 143–47. http://dx.doi.org/10.1016/j.biortech.2015.01.004.

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27

Kuang, Cuiping, Huidi Liang, Jie Gu, Tsungchow Su, Xute Zhao, Hongling Song, Yue Ma, and Zhichao Dong. "Morphological process of a restored estuary downstream of a tidal barrier." Ocean & Coastal Management 138 (March 2017): 111–23. http://dx.doi.org/10.1016/j.ocecoaman.2017.01.012.

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28

Granjo, José F. O., Dinis S. Nunes, Belmiro P. M. Duarte, and Nuno M. C. Oliveira. "A comparison of process alternatives for energy-efficient bioethanol downstream processing." Separation and Purification Technology 238 (May 2020): 116414. http://dx.doi.org/10.1016/j.seppur.2019.116414.

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29

Martin, L., L. Wittmann, and S. Berensmeier. "Downstream process development for a small molecule from saline microbial fermentation." Chemie Ingenieur Technik 92, no. 9 (August 28, 2020): 1239. http://dx.doi.org/10.1002/cite.202055376.

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30

Ostermann, M., P. Totchum-Simo, G. Schembecker, K. Wohlgemuth, and C. Bramsiepe. "Energy Efficiency Analysis towards Early Decision-Making in Downstream Process Development." Chemie Ingenieur Technik 88, no. 9 (August 29, 2016): 1223. http://dx.doi.org/10.1002/cite.201650450.

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31

KANDA, Keiichi, Yoshio MURAMOTO, and Yuichiro FUJITA. "Numerical Simulation of Scour Process in Downstream of Bed Protection Works." PROCEEDINGS OF HYDRAULIC ENGINEERING 37 (1993): 657–62. http://dx.doi.org/10.2208/prohe.37.657.

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32

Mislin, Alexandra A., and Rachel Campagna. "Temporal influences and downstream consequences of actions during the bargaining process." Academy of Management Proceedings 2014, no. 1 (January 2014): 14445. http://dx.doi.org/10.5465/ambpp.2014.14445abstract.

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33

Anand, Pinki, Rajendra Kumar Saxena, and Ruchi G. Marwah. "A novel downstream process for 1,3-propanediol from glycerol-based fermentation." Applied Microbiology and Biotechnology 90, no. 4 (March 1, 2011): 1267–76. http://dx.doi.org/10.1007/s00253-011-3161-2.

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34

Benito-Román, Ó., E. Alonso, L. Palacio, P. Prádanos, and M. J. Cocero. "Purification and isolation of β-glucans from barley: Downstream process intensification." Chemical Engineering and Processing: Process Intensification 84 (October 2014): 90–97. http://dx.doi.org/10.1016/j.cep.2013.12.006.

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35

Rangelow, I. W. "Nano-resolution tri-level process by downstream- microwave rf-biased etching." Microelectronic Engineering 17, no. 1-4 (March 1992): 349–52. http://dx.doi.org/10.1016/0167-9317(92)90072-y.

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36

Welsh, John P., Michael A. Rauscher, Haiying Bao, Sandra Meissner, InKwan Han, Thomas O. Linden, and Jennifer M. Pollard. "Domain antibody downstream process optimization: High-throughput strategy and analytical methods." Engineering in Life Sciences 16, no. 2 (August 6, 2015): 133–42. http://dx.doi.org/10.1002/elsc.201400255.

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37

Choeriyah, Sahara Syarifatul, and Eko Budi Setiawan. "Supply Chain Management Implementation on Snacks Production Process." International Journal of New Media Technology 5, no. 2 (March 19, 2019): 62–70. http://dx.doi.org/10.31937/ijnmt.v5i2.840.

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PQR’s company is a company that located in Citeureup Tasikmalaya. The company is engaged in the production of snacks such as mie lidi. The production strategy that used by this company is a make to stock. The company organizes activities from upstream to downstream. Activities that occur in the upstream is to procure raw materials to suppliers by purchasing department. However, some problem was found when the purchasing department has difficulty determining the amount of raw material for the procurement process. This is due to uncertain demand from distributors. While the activities in downstream is sending the product to distributor by shipping department. Some problem that occurs in the downstream were shipping department has difficulty to make schedule product shipments because there was a delay in the product delivery process. All problem occurs because there is no system that can manage supply chain information. So, the implementation of supply chain management by using the forecasting method of single moving average and calculation of sale limits of raw material and product inventory using safety stock method, it was expected to provide a solution to this problem.
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38

Zhang, Xu, Chao Liang, and Wei Yu Li. "Automatic Process Intermediate Model Generation in Process Planning." Advanced Materials Research 834-836 (October 2013): 1436–43. http://dx.doi.org/10.4028/www.scientific.net/amr.834-836.1436.

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In process planning of machined part, three-dimensional process intermediate models are necessary for process design, documentation, and downstream applications including clamping design, NC programing, and process analysis. An automatic process intermediate model generation method is proposed in this paper for machined part represented in B-Rep solid model. Machining features are recognized and classified according to process type. Process plan is expressed in terms of machining features and feature surface modification operations in solid model. Local modification operations are applied to part model to move, replace or remove feature surface resembling machining process. Process intermediate models are generated automatically in a batch manner by applying geometry and topology modification operations directly on B-Rep model for each machining operation. The proposed algorithm is implemented in a CAPP tool developed in solid modeler ACIS.
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39

Wang, Zhi Liang, Yong Jie Wang, and Jin Ming Luo. "A Comprehensive Indicator Representing Process: Water Environment Sustainability Index for Downstream Marsh." Applied Mechanics and Materials 316-317 (April 2013): 741–47. http://dx.doi.org/10.4028/www.scientific.net/amm.316-317.741.

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Several issues impact environment sustainability, its evaluation index usually contains so high number of indicators and parameters that it is constrained in data-scarce regions where lack of consistent time series data especially. So, the assessment would just be carried on present situation, rarely on process. A water environment sustainability index for downstream marsh representing process was developed and proposed in this paper. Applied to Zhalong Wetland, the WESI scores the highest (3.47) at 1988 to the lowest (1.92) at 2005 that could be divided into 3 periods: 1980’s (good level), 1990’s (bad level) and 2000’s (rising up slowly under human manipulation). To maintain it at a good level, it is necessary to drain water from Nenjiang River year by year.
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40

Urthaler, Jochen, Wolfgang Buchinger, and Roman Necina. "Improved downstream process for the production of plasmid DNA for gene therapy." Acta Biochimica Polonica 52, no. 3 (September 30, 2005): 703–11. http://dx.doi.org/10.18388/abp.2005_3434.

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Gene therapy and genetic vaccines promise to revolutionize the treatment of inherited and acquired diseases. Since viral vectors are generally associated with numerous disadvantages when applied to humans, the administration of naked DNA, or DNA packed into lipo- or polyplexes emerge as viable alternatives. To satisfy the increasing demand for pharmaceutical grade plasmids we developed a novel economic downstream process which overcomes the bottlenecks of common lab-scale techniques and meets all regulatory requirements. After cell lysis by an in-house developed gentle, automated continuous system the sequence of hydrophobic interaction, anion exchange and size exclusion chromatography guarantees the separation of impurities as well as undesired plasmid isoforms. After the consecutive chromatography steps, adjustment of concentration and final filtration are carried out. The final process was proven to be generally applicable and can be used from early clinical phases to market-supply. It is scaleable and free of animal-derived substances, detergents (except lysis) and organic solvents. The process delivers high-purity plasmid DNA of homogeneities up to 98% supercoiled form at a high yield in any desired final buffer.
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41

Patraşcu, Iulian, Costin Sorin Bîldea, and Anton A. Kiss. "Eco-efficient Downstream Processing of Biobutanol by Enhanced Process Intensification and Integration." ACS Sustainable Chemistry & Engineering 6, no. 4 (February 28, 2018): 5452–61. http://dx.doi.org/10.1021/acssuschemeng.8b00320.

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42

Spencer, J. R. "CIVIL LIABILITY FOR ABUSE OF THE CRIMINAL PROCESS: DOWNSTREAM OF THREE RIVERS." Cambridge Law Journal 62, no. 3 (November 3, 2003): 543–45. http://dx.doi.org/10.1017/s0008197303276406.

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43

Messina, S., G. L. Vita, M. G. De Pasquale, A. Cama, A. Licata, S. Romeo, A. Ciranni, et al. "T.P.40 Implication of SIRT1 and its downstream pathways in dystrophic process." Neuromuscular Disorders 22, no. 9-10 (October 2012): 864–65. http://dx.doi.org/10.1016/j.nmd.2012.06.205.

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44

Fazeli, A., S. A. Shojaossadati, M. R. Fazeli, and H. Ilka. "Optimization of fed-batch refolding in downstream process of recombinant interferon β1b." New Biotechnology 25 (September 2009): S177. http://dx.doi.org/10.1016/j.nbt.2009.06.714.

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45

Griffiths, P., N. J. Titchener-Hooker, and Y. H. Zhou. "Using Feasible Regions to Investigate the Operability of Integrated Downstream Process Designs." IFAC Proceedings Volumes 34, no. 5 (June 2001): 287–92. http://dx.doi.org/10.1016/s1474-6670(17)34234-9.

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46

Glover, Clive, Daniel Smith, and Damian Marshall. "Room for improvement: tackling suboptimal downstream process unit operations for viral vectors." Cell and Gene Therapy Insights 5, S2 (March 18, 2019): 165–76. http://dx.doi.org/10.18609/cgti.2019.024.

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47

Bichi, A. B., W. R. Smith, and J. G. Wissink. "Solidification and downstream meniscus prediction in the planar-flow spin casting process." Chemical Engineering Science 63, no. 3 (February 2008): 685–95. http://dx.doi.org/10.1016/j.ces.2007.10.003.

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48

Bataillé, Laetitia, Isabelle Delon, Jean Philippe Da Ponte, Nicholas H. Brown, and Krzysztof Jagla. "Downstream of Identity Genes: Muscle-Type-Specific Regulation of the Fusion Process." Developmental Cell 19, no. 2 (August 2010): 317–28. http://dx.doi.org/10.1016/j.devcel.2010.07.008.

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49

In, Man-Jin, Dong Chung Kim, and Hee Jeong Chae. "Downstream process for the production of yeast extract using brewer's yeast cells." Biotechnology and Bioprocess Engineering 10, no. 1 (February 2005): 85–90. http://dx.doi.org/10.1007/bf02931188.

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50

Rüdt, Matthias, Till Briskot, and Jürgen Hubbuch. "Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology." Journal of Chromatography A 1490 (March 2017): 2–9. http://dx.doi.org/10.1016/j.chroma.2016.11.010.

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