Academic literature on the topic 'Doyle Collection'

In the paper we study a family of modal nonmonotonic logics closely related to the family of modal nonmonotonic logics proposed by McDermott and Doyle. For a modal logic S and a fixed collection of formulas X we introduce the notion of an ( S, X)-expansion. We restrict to modal logics which have a complete Kripke semantics. We study the properties of ( S, X)-expansions and show that in many respects they are analogous to the properties of S-expansions in nonmonotonic modal logics of McDermott and Doyle.

AbstractThe original description of the large and characteristic belemnite species Arctoteuthis bluethgeni Doyle was based on fragmentary material from a relatively uncertain stratigraphic interval in Kong Karls Land, Svalbard. Recent collection of a belemnite assemblage in the Lower Cretaceous Rurikfjellet Formation on Spitsbergen include numerous complete specimens, allowing a detailed description of the species. With the exception of a specimen reported from Arctic Canada, its distribution is restricted to Svalbard. Its stratigraphic range appears to be restricted to the upper Valanginian – lower Hauterivian from ages obtained from palynostratigraphy. A. bluethgeni is therefore considered to be a useful Lower Cretaceous guide fossil in the Boreal High Arctic.

Arthur Conan Doyle famously popularised science in his series of detective stories by placing its three constitutive elements (scientific knowledge, the collection of evidence, and art of making inferences), in his protagonist Sherlock Holmes. The legacy is present in contemporary crime fiction, but the competencies have been distributed among a group of individuals involved in the investigation. This distribution has affected and changed the position of the detective vis-à-vis scientific expertise. Science, chiefly in the form of different branches of forensics, is as indispensable as the detective, and authors have been working out different ways of making the two work together. As an example of this cooperation, the paper examines Mark Billingham’s 2015 novel Time of Death.

Recent efforts have been made to increase our understanding of the dynamics of ice-sheet hydrology. Notably, much work has focused on the southwest sector of the Greenland ice sheet (GrIS), with intense data collection on diurnal to interannual timescales (e.g. Bartholomew and others, 2012; Cowton and others, 2013; Doyle and others, 2013). Observations show a close correlation between surface meltwater production and the seasonal ice-sheet acceleration, and it is a well-accepted hypothesis that an increase in the former drives the latter via meltwater transfer through the subglacial drainage system (e.g. Zwally and others, 2002). However, due to the remote nature and complexity of the subglacial domain, a satisfactory description at the process level has remained elusive. Better understanding of the coupling of meltwater forcing on ice velocity through the subglacial component is therefore necessary to improve the physical integrity of ice-sheet models.

This statement is an opening point for the discussion on the effects of the dominance of English as a language of science on other languages and speech communities. The global search for a common auxiliary language that allows unprecedented possibilities for international cooperation, and the resulting prevalence and dominance of English in science, vary in kind and degree, as well as in effects, across language communities and countries. The volume under review is an outstanding one with respect to both thematic diversity and depth of analysis in most of its essays. Since Fishman et al. 1977 edited the first collection of essays on the spread of English, numerous valuable books on the status of English as a global language have been published (Flaitz 1988, Doyle 1989, Kachru 1992, Pennycook 1994, Hartmann 1996, Fishman et al. 1996, Crystal 1997, Ryan & Zuber-Skerritt 1999), but there is no doubt that Ulrich Ammon has edited an extremely innovative and insightful volume.

The DNA extraction is one of the first steps and plays animportant role in study on genome of any species on earth. Depending on the purpose and object of study, DNA can be extracted from various tissues.For plants, DNA is usually extracted from the leaves, seeds and young buds, in which these tissues are the best DNA source and can be extracted easily. However, the collection of sample from mature trees, which are generally tall, isdifficult and need more facilities. Consequently, it leads to be limited for the study scope.The proposed solutionis to use a wood tissue instead ofthe leaves, seeds and young due to they are easily collected. The problem is very difficult to extract high quality DNA from the wood tissue (Verbylaite et al., 2010). However, if the extraction of DNA from wood tissue would besuccessful, it would open up many research directions and could turn techniques that seemed unfeasible before into the effective solution. Extracting and analyzing DNA from dried wood and processed wood could be developed to explore the possibility of identifying the species and theirorigin. This could be greatly useful for determining the legality of wood log and wood products, and for deterring trade in illegal wood products (Tsumura et al.,2011). Currently, there are some commercialized kits, enabling DNA extraction from wood more easily,e.g. DNeasy Plant Mini Kit (Qiagen), Nucleospin Plant II (Macherey-Nagel), Genomic DNA Purification Kit (Fermentas) and innuPREP Plant DNA Kit (Analytik Jena). However, the commercial Kitsare expensive. Meanwhile, there are some cheaper methods, applying for DNA extraction from wood successfully, such as SDS method (Edwards et al.,1991; Goodwin and Lee, 1993), protein precipitation protocol (Dellaporta et al., 1983; Fang et al., 1992), especially CTAB method, obtaining with a high DNA concentration (Doyle J and Doyle H., 1987). The DNA extracted by CTAB protocol is less pure; however, they are still suitable to use in molecular biology. The objective of this work was to optimize the conditions of CTAB protocol for DNA extraction from wood. The two parameters centrifugation time and volume ratio of isopropanol to solutions containing DNA that affect the yield and quality DNA were explored using the response surface methodology (RSM). The central composite design (CCD) was used to obtain the experimental design matrix. This approach has limited number of actual experiments performed where as allowing probing into possible interaction between these parameters studied and their effect on quantity and quality DNA.

This paper reflects on the key issues of literary translation approaches suggested by Mykola Dmytrenko, an outstanding Ukrainian prose translator. Despite the vast research made by Ukrainian and foreign scholars regarding the translation (A. Bennet, S. Bassnet, M. Strykha) little is known about the contribution made by Ukrainian translators to the promotion of the Ukrainian literature on the international arena. Mykola Dmytrenko’s original arguments coming from value-based interview questions reveal the nature of translating process in terms of cultural transfer with a special emphasis on the literary standards and the distinctive nature of translation paradigm. As many translation theorists and researchers claim, there has been an accepted recognition of the fact that the use of the strategies and techniques of contemporary linguistics shift away to cultural studies. This article attempts to outline the scope of translation as a process by syndicating various extralinguistic phenomena as they occur in Mykola Dmytrenko’s translation project. Firstly, his translation programme embraces the issues of self with their close relation to the problems of cultural identity and the ones connected with tracing the target text within its new sociocultural context. Secondly, Mykola Dmytrenko’s translations provide his exceptional position in developing general principles through which he adequately clarifies the algorithm of choosing literary texts for translation and sheds light on the author selection as well as the ways literary translation networks function in a number of respects. Furthermore, the translator aims his works to be viewed in a broader context of building up the relations with the author of the original on the equal basis so that the target reader would feel he deals with the original text, not with the translation. With this purpose, Mykola Dmytrenko claims that he not only aspires to getting Ukrainian readers acquainted with the masterpieces of world literature, but also aims to develop the ability of cultivating their deductive skills as well as sharpening observation and forming the power of imagination. These explicate the reasons for the translator’s selection of literary texts by A. C. Doyle («A Scandal in Bohemia», «The Red-headed League», «A Case of Identity», «Boscombe Valley Mystery», «Thе Five Orange Pips», etc.). All these have been illustrated by the examples from A. Conan Doyle’s collection of detective stories «The Adventures of Sherlock Holmes» («The Reigate Puzzle»). So, the translator’s pragmatic view comes to be both from an inborn talent and a professional skill to produce the target text of the highest quality.

Every civilization has knowledge about health. From the beginning until now the most vulnerable groups in terms of health are toddlers and pregnant women. In the Wakatobi community, the health of children or toddlers is also an important aspect that is a priority of the local government to improve the quality of children's lives. In an effort to improve the quality of life for toddlers, the Wakatobi community has a culture as a traditional stunting that has been growing and developing in the community. This study used an ethnographic approach, so the data collection of data analysis uses ethnographic principles. This approach was expected to reveal how the Wakatobi community views health and quality of life for toddlers. The results of this study indicated that the Wakatobi community has had a traditional earrings concept called the Hedole Dole. Through the Hedole Dole ritual, toddlers have special treatment from a sando or traditional birth attendant. After experiencing the Dole Dole ritual, Wakatobi children possessed strong endurance. They will have strong endurance to fight various weather changes. Wakatobi believes and believes that this tradition has improved the quality of life and endurance of their toddlers. They also assume that healthy children are children who have a healthy body and mind. Wakatobi people think that through the ritual tradition of Dole Dole food can have a strong immune system. The process of their idols will be given various types of herbs and treatments that make their bodies stronger and resistant to various diseases.

Abstract Background ST258 K. pneumoniae and ST131 E. coli clones are considered vectors for the global spread of multidrug resistance. We evaluated the activity of β-lactams in combination with QPX7728, a novel β-lactamase inhibitor active against all β-lactamase classes, against a collection of 210 isolates belonging to these clones collected from a worldwide surveillance study. Methods A total of 118 ST258 K. pneumoniae and 92 ST131 E. coli (single loci variant also included) were susceptibility tested by reference broth microdilution against various β-lactams ± QPX7728 and comparator agents. All isolates were screened for β-lactamases using whole genome sequencing analysis. Results All β-lactam agents had limited activity against 118 ST258 K. pneumoniae (1.7–7.6% susceptible). Among these, 104 carried carbapenemase-encoding genes: 66 KPC variants, 20 NDM and 17 OXA-48-like. One isolate carried 2 carbapenemases. The addition of QPX7728 at 4 mg/L or 8 mg/L lowered the MICs for cefepime (MIC50/90, 0.25/1 mg/L and MIC50/90, 0.12/0.5 mg/L), ceftolozane (MIC50/90, 0.5/ > 32 mg/L and MIC50/90, 0.25/16 mg/L), ertapenem (MIC50/90, 0.12/2 mg/L and MIC50/90, 0.06/0.5 mg/L), and meropenem (MIC50/90, 0.06/0.5 mg/L and MIC50/90, 0.03/0.12 mg/L; Table). QPX7728 at 4 mg/L reduced the ceftibuten (MIC50/90, 0.25/8 mg/L) or tebipenem (MIC50/90, 0.12/2 mg/L) MICs for ST258 isolates. E. coli ST131 carried mainly CTX-M variant (85 isolates), but 6 isolates harbored carbapenemases. Carbapenems were the only β-lactams displaying > 80.0% activity against ST131 E. coli, followed by piperacillin-tazobactam (79.3% susceptible). Only 5.4%and 41.3% ST131 isolates were susceptible to cefepime and ceftibuten, respectively. MIC50/MIC90 values for these agents with QPX7728 were ≤ 0.015/≤ 0.015 mg/L for cefepime and ≤ 0.015/0.06 mg/L for ceftolozane with the inhibitor at 8 mg/L and ≤ 0.015/0.03 mg/L for ceftibuten with the inhibitor at 4 mg/L. Conclusion QPX7728 lowered the MICs for all agents tested to clinically achievable levels when tested against isolates multidrug resistant belonging to important clones responsible to the dissemination of KPC, CTX variants, and metallo-β-lactamases. The development of this broad β-lactamase inhibitor should be pursued. Table 1 Disclosures Mariana Castanheira, PhD, 1928 Diagnostics (Research Grant or Support)A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Amplyx Pharmaceuticals (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)GlaxoSmithKline (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support)Pfizer (Research Grant or Support)Qpex Biopharma (Research Grant or Support) Jill Lindley, Allergan (Research Grant or Support)Qpex Biopharma (Research Grant or Support) Timothy B. Doyle, Allergan (Research Grant or Support)Allergan (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Pfizer (Research Grant or Support)Qpex Biopharma (Research Grant or Support) Olga Lomovskaya, PhD, Qpex Biopharma (Employee)

Podocarpic acid (a diterpenoid resin acid extracted from the Podocarpacea specie of plants) has shown cytotoxicity against carcinoma of the nasopharynx. Since this discovery has been made, research has been performed in order to alter the structure of the resin acid so as to increase the anticancer activity. The carboxylic acid and phenol functional groups, which are present in podocarpic acid, make it possible to synthesize new derivatives selectively at the C-15, C-13, and C-7 positions as well as by substitution of the phenol hydroxyl group. Thus numerous derivatives can be prepared, in high yield, for the purpose of investigating their potential, as new drug leads for the treatment of cancer. In this study, Doyle's catalyst (Dirhodium tetrakis caprolactamate) was used to form a novel derivative in high yield (85%) which contained a 3-membered aziridine ring at the C-6 and C-7 position. The main thrust of this research involved the formation a series of novel derivatives of the aziridine compound by utilizing phenol and m-chlorophenol as nucleophiles to open the aziridine ring. These novel compounds will now be sent to the National Institute of Health (NIH) for bioassay against 60 human cancer cell lines.
M.S.
Department of Chemistry
Sciences
Industrial Chemistry MS