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Journal articles on the topic 'Dp103'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Singh, Shikha Satendra. "Characterization of a novel regulator of AKT/mTOR signaling in gastric cancer." Journal of Clinical Oncology 34, no. 4_suppl (2016): 68. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.68.

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68 Background: Gastric cancer (GC) is a leading cause of cancer-related death with poor prognosis and “one-size fits all approach”. Dysregulation of PI3K/Akt/mTOR pathway is a common event in GC with PIK3CAmutations reported to correlate with poor prognosis. With prognosis far from satisfactory, we aimed to identify novel surrogate biomarkers. We hypothesize the role of DP103, a DEAD-box RNA helicase, as a novel surrogate biomarker for GC by regulating the PI3K/Akt/mTOR pathway. Additionally, we shed light on high DP103 GC cells responding to Akt/mTOR dual inhibitor treatment, indicating its p

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Mouillet, Jean-François, Xiaomei Yan, Qinglin Ou, et al. "DEAD-Box Protein-103 (DP103, Ddx20) Is Essential for Early Embryonic Development and Modulates Ovarian Morphology and Function." Endocrinology 149, no. 5 (2008): 2168–75. http://dx.doi.org/10.1210/en.2007-1237.

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The DEAD-box helicase DP103 (Ddx20, Gemin3) is a multifunctional protein that interacts with Epstein-Barr virus nuclear proteins (EBNA2/EBNA3) and is a part of the spliceosomal small nuclear ribonucleoproteins complex. DP103 also aggregates with the micro-RNA machinery complex. We have previously shown that DP103 interacts with the nuclear receptor steroidogenic factor-1 (SF-1, NR5A1), a key regulator of reproductive development, and represses its transcriptional activity. To further explore the physiological function of DP103, we disrupted the corresponding gene in mice. Homozygous Dp103-null

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Voss, Marc D., Annette Hille, Stephanie Barth, et al. "Functional Cooperation of Epstein-Barr Virus Nuclear Antigen 2 and the Survival Motor Neuron Protein in Transactivation of the Viral LMP1 Promoter." Journal of Virology 75, no. 23 (2001): 11781–90. http://dx.doi.org/10.1128/jvi.75.23.11781-11790.2001.

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ABSTRACT Epstein-Barr virus nuclear antigen 2 (EBNA2) is essential for viral transformation of B cells and transactivates cellular and viral target genes by binding RBPJκ tethered to cognate promoter elements. EBNA2 interacts with the DEAD-box protein DP103 (DDX20/Gemin3), which in turn is complexed to the survival motor neuron (SMN) protein. SMN is implicated in RNA processing, but a role in transcriptional regulation has also been suggested. Here, we show that DP103 and SMN are complexed in B cells and that SMN coactivates the viral LMP promoter in the presence of EBNA2 in reporter gene assa

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Yan, Xiaomei, Jean-François Mouillet, Qinglin Ou, and Yoel Sadovsky. "A Novel Domain within the DEAD-Box Protein DP103 Is Essential for Transcriptional Repression and Helicase Activity." Molecular and Cellular Biology 23, no. 1 (2003): 414–23. http://dx.doi.org/10.1128/mcb.23.1.414-423.2003.

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ABSTRACT Members of the DEAD-box family of helicases, distinguished by a core characteristic sequence of Asp-Glu-Ala-Asp, are expressed in a wide range of prokaryotes and eukaryotes and exhibit diverse cellular functions, including DNA transcription, recombination and repair, RNA processing, translation, and posttranslational regulation. Although ubiquitous, the function of most DEAD-box proteins is unknown. We and others have recently cloned DP103, which harbors conserved DEAD-box, helicase, and ATPase domains in its N terminus. DP103 (also termed Gemin3 and DDX20) interacts with SF-1, SMN, E

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Heba, G. Abd El-Aziz, S. El-Shaer Shereen, M. Abd El-Latif Doaa, Gomaa M., and M. Kamel Mahmoud. "Dp103 in Egyptian Patients with Breast Cancer: Prognosis to Lymph Node Metastasis." Journal of Cancer and Tumor International 5, no. 4 (2017): 1–10. https://doi.org/10.9734/JCTI/2017/35052.

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<strong>Background:</strong> Dp103 is a multifunctional protein which binds and unwinds RNA secondary structures, therefore plays a vital role in RNA metabolism from birth to death. <strong>Aims: </strong>The present study aimed to evaluate both serum levels and tissue expressions of Dp103 and explored their possible roles in lymph node metastasis within breast cancer Egyptian patients. <strong>Methodology:</strong> Sixty patients were enrolled in this study; they were subdivided into two groups. First group included forty females newly diagnosed as primary breast cancer their age ranged from

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6

Ou, Qinglin, Jean-François Mouillet, Xiaomei Yan, Christoph Dorn, Peter A. Crawford, and Yoel Sadovsky. "The DEAD Box Protein DP103 Is a Regulator of Steroidogenic Factor-1." Molecular Endocrinology 15, no. 1 (2001): 69–79. http://dx.doi.org/10.1210/mend.15.1.0580.

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Abstract The nuclear receptor steroidogenic factor-1 (SF-1) is essential for development of the gonads, adrenal gland, and the ventromedial hypothalamic nucleus. It also regulates the expression of pivotal steroidogenic enzymes and other important proteins in the reproductive system. We sought to elucidate the mechanisms that govern the transcriptional activity of SF-1. We demonstrate here that a previously uncharacterized domain, located C-terminal to the DNA binding domain of SF-1, exhibits transcriptional repression function. Point mutations in this domain markedly potentiate the transcript

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Lee, Martin B., Lioudmila A. Lebedeva, Miyuki Suzawa, Subhagya A. Wadekar, Marion Desclozeaux, and Holly A. Ingraham. "The DEAD-Box Protein DP103 (Ddx20 or Gemin-3) Represses Orphan Nuclear Receptor Activity via SUMO Modification." Molecular and Cellular Biology 25, no. 5 (2005): 1879–90. http://dx.doi.org/10.1128/mcb.25.5.1879-1890.2005.

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ABSTRACT Structural analysis of nuclear receptor subfamily V orphan nuclear receptors suggests that ligand-independent mechanisms must regulate this subclass of receptors. Here, we report that steroidogenic factor 1 (SF-1) and liver receptor homolog 1 are repressed via posttranslational SUMO modification at conserved lysines within the hinge domain. Indeed, mutating these lysines or adding the SUMO isopeptidase SENP1 dramatically increased both native and Gal4-chimera receptor activities. The mechanism by which SUMO conjugation attenuates SF-1 activity was found to be largely histone deacetyla

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Lee, Kangseok, Margareta D. Pisarska, Jeong-Jae Ko, et al. "Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis." Biochemical and Biophysical Research Communications 336, no. 3 (2005): 876–81. http://dx.doi.org/10.1016/j.bbrc.2005.08.184.

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9

Shin, Eun Myoung, Motomi Osato, Alan Prem Kumar, and Vinay Tergaonkar. "RNA helicase DP103 and TAK1: a new connection in cancer." Molecular & Cellular Oncology 2, no. 3 (2015): e985911. http://dx.doi.org/10.4161/23723556.2014.985911.

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Shin, Eun Myoung, Hui Sin Hay, Moon Hee Lee, et al. "DEAD-box helicase DP103 defines metastatic potential of human breast cancers." Journal of Clinical Investigation 124, no. 9 (2014): 3807–24. http://dx.doi.org/10.1172/jci73451.

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11

Curmi, Frank, and Ruben J. Cauchi. "The multiple lives of DEAD-box RNA helicase DP103/DDX20/Gemin3." Biochemical Society Transactions 46, no. 2 (2018): 329–41. http://dx.doi.org/10.1042/bst20180016.

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Gemin3, also known as DDX20 or DP103, is a DEAD-box RNA helicase which is involved in more than one cellular process. Though RNA unwinding has been determined in vitro, it is surprisingly not required for all of its activities in cellular metabolism. Gemin3 is an essential gene, present in Amoeba and Metazoa. The highly conserved N-terminus hosts the helicase core, formed of the helicase- and DEAD-domains, which, based on crystal structure determination, have key roles in RNA binding. The C-terminus of Gemin3 is highly divergent between species and serves as the interaction site for several ac

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El-Aziz, Heba, Shereen El-Shaer, Doaa Abd El-Latif, M. Gomaa, and Mahmoud Kamel. "Dp103 in Egyptian Patients with Breast Cancer: Prognosis to Lymph Node Metastasis." Journal of Cancer and Tumor International 5, no. 4 (2017): 1–10. http://dx.doi.org/10.9734/jcti/2017/35052.

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13

Gillian, Anne Lynn, and John Svaren. "The Ddx20/DP103 Dead Box Protein Represses Transcriptional Activation by Egr2/Krox-20." Journal of Biological Chemistry 279, no. 10 (2003): 9056–63. http://dx.doi.org/10.1074/jbc.m309308200.

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Fuller-Pace, F. V., A. M. F. Jacobs, and S. M. Nicol. "Modulation of transcriptional activity of the DEAD-box family of RNA helicases, p68 (Ddx5) and DP103 (Ddx20), by SUMO modification." Biochemical Society Transactions 35, no. 6 (2007): 1427–29. http://dx.doi.org/10.1042/bst0351427.

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SUMO (small ubiquitin-related modifier) modification is known to have diverse effects on the activity of transcriptional regulators, often through alterations in their localization or interactions with other factors, and in most of the cases is associated with transcriptional repression. The DEAD-box family of RNA helicases includes a large number of proteins that are involved in various cellular processes. Several members are now known to be multifunctional and their activities are thought to be governed by interactions with other partners, which may be regulated by post-translational modific

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15

Campbell, L. "Direct interaction of Smn with dp103, a putative RNA helicase: a role for Smn in transcription regulation?" Human Molecular Genetics 9, no. 7 (2000): 1093–100. http://dx.doi.org/10.1093/hmg/9.7.1093.

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16

Ahmad, Siti Hamizah, Noor Dina Md Amin, Noorwirdawati Ali, et al. "The Effects of Domestic Plastic Waste on Concrete Properties: Sustainable Replacement of Aggregates." Journal of Advanced Research in Applied Mechanics 132, no. 1 (2025): 185–94. https://doi.org/10.37934/aram.132.1.185194.

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Plastic waste poses a major environmental challenge in Southeast Asia, with Malaysia as the largest contributor. Recycling offers a solution by incorporating plastic waste as a substitute material in concrete production. This approach addresses environmental concerns while promoting sustainable construction practices. This study investigates the optimal ratios of cement, water, plastic replacement, and aggregate in concrete compositions. Furthermore, it examines the influence of domestically sourced waste plastic on concrete properties. A comparative analysis is conducted between concretes wit

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17

Grundhoff, Adam T., Elisabeth Kremmer, Özlem Türeci, et al. "Characterization of DP103, a Novel DEAD Box Protein That Binds to the Epstein-Barr Virus Nuclear Proteins EBNA2 and EBNA3C." Journal of Biological Chemistry 274, no. 27 (1999): 19136–44. http://dx.doi.org/10.1074/jbc.274.27.19136.

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18

Su, Shao Bo, Ji-liang Gao, Wang-hua Gong, et al. "T21/DP107, A Synthetic Leucine Zipper-Like Domain of the HIV-1 Envelope gp41, Attracts and Activates Human Phagocytes by Using G-Protein-Coupled Formyl Peptide Receptors." Journal of Immunology 162, no. 10 (1999): 5924–30. http://dx.doi.org/10.4049/jimmunol.162.10.5924.

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Abstract A leucine zipper-like domain, T21/DP107, located in the amino terminus of the ectodomain of gp41, is crucial to the formation of fusogenic configuration of the HIV-1 envelope protein gp41. We report that the synthetic T21/DP107 segment is a potent stimulant of migration and calcium mobilization in human monocytes and neutrophils. The activity of T21/DP107 on phagocytes was pertussis toxin-sensitive, suggesting this peptide uses Gi-coupled seven-transmembrane receptor(s). Since the bacterial chemotactic peptide fMLP partially desensitized the calcium-mobilizing activity of T21/DP107 in

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Garcia, J. V., M. P. Stoppelli, K. L. Thompson, S. J. Decker, and M. R. Rosner. "Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors." Journal of Cell Biology 105, no. 1 (1987): 449–56. http://dx.doi.org/10.1083/jcb.105.1.449.

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The identification of a novel protein from Drosophila melanogaster that binds both mammalian epidermal growth factor (EGF) and insulin has been reported (Thompson, K. L., S. J. Decker, and M. R. Rosner, 1985, Proc. Natl. Acad. Sci. USA., 82:8443-8447). This 100-kD protein (designated dp100) is also recognized by an antiserum against the human EGF receptor. To further characterize the properties of this protein, we have determined the binding spectrum, glycosylation state, and cellular distribution of dp100. Our results indicate that dp100 binds to other insulin-like and EGF-like growth factors

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Lin, Rui, Cheng Liu, and Thomas S. Edgington. "Discovery and Characterization of a Novel Large Non-Coding RNA Transcript, the Mouse Alpha Gene." Blood 104, no. 11 (2004): 4279. http://dx.doi.org/10.1182/blood.v104.11.4279.4279.

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Abstract Recently, a new class of RNAs has been identified that, like mRNAs, are usually transcribed by RNA polymerase II, but lack significant translated open reading frames. They are non-coding RNAs (ncRNAs) that exert roles directly as RNAs, and function as genetic regulators, or riboregulators. In the present study, we discovered a novel very large ncRNA. From differential gene profiling of CD31 positive tumor microvascular endothelial cells from a murine colon carcinoma, we amplified an ~380 bp nucleotide sequence, DP100. This RNA was present in tumor cells as well as tumor vascular endot

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Garcia, J. V., M. P. Stoppelli, S. J. Decker, and M. R. Rosner. "An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity." Journal of Cell Biology 108, no. 1 (1989): 177–82. http://dx.doi.org/10.1083/jcb.108.1.177.

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We have recently described the purification and characterization of an insulin-degrading enzyme (IDE) from Drosophila melanogaster that can cleave porcine insulin, is highly conserved through evolution and is developmentally regulated. We now report that the IDE is, in fact, an insulin EGF-binding protein (dp100) that we had isolated previously from Drosophila using an antihuman EGF receptor antiserum. This conclusion is based upon the following evidence. (a) dp100, identified by its ability to cross-link to labeled insulin, EGF, and transforming growth factor-alpha (TGF-alpha), and to be immu

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22

Connolly, Aveen, Marianna Philippidou, Patrick Gordon, Chris Wincup, Fiona Worsnop, and Daniel Creamer. "DP10 Scalp disease in dermatomyositis." British Journal of Dermatology 191, Supplement_1 (2024): i111. http://dx.doi.org/10.1093/bjd/ljae090.232.

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Abstract The clinical presentation of dermatomyositis (DM) is heterogeneous, with patients expressing varying degrees of muscle and skin inflammation. Scalp inflammation is often disregarded in the clinical assessment and is seldom the subject of clinical studies. However, DM at this site contributes significantly to the symptom burden, a feature heightened by the scalp’s comparative lack of response to standard immunosuppressant therapy. As well as a sparsity of studies detailing clinical features in scalp DM, the literature on scalp histopathology is also limited. In an attempt to define the

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Metzing, Maximilian, Pietro Crivello, Thuja Meurer, et al. "HLA-DM Mediates Permissiveness of HLA-DPB1 T Cell Epitope Mismatches in Unrelated HCT." Blood 134, Supplement_1 (2019): 3211. http://dx.doi.org/10.1182/blood-2019-129921.

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Introduction: In 8/8 matched unrelated donor (UD) hematopoietic cell transplantation (HCT), permissive HLA-DPB1 (DP) mismatches within the same functional T Cell Epitope (TCE) group are associated with better outcomes compared to non-permissive mismatches across different TCE groups (Fleischhauer, Blood 2017). This clinical advantage has been shown to be associated with limited in vitro T cell alloreactivity (Meurer, Front Immunol 2019), which in turn is dependent on polymorphic peptide contact amino acids in the DP molecule (Crivello, Biol Blood Marrow Transplant 2015). The HLA class II immun

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Minter, Ross, and Katheleen J. Gardiner. "Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome." Genes 12, no. 11 (2021): 1697. http://dx.doi.org/10.3390/genes12111697.

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Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability. The Dp10(1)Yey (Dp10) is a mouse model of DS that is trisomic for orthologs of 25% of the Hsa21 protein-coding genes, the entirety of the Hsa21 syntenic region on mouse chromosome 10. Trisomic genes include several involved in brain development and function, two that modify and regulate the activities of sex hormones, and two that produce sex-specific phenotypes as null mutants. These last four are the only Hsa21 genes with known sexually dimorphic properties. Relatively lit

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Cai, Chunjiang, Ying Ren, Jianhua Cao, Shengya Fang, Leying Zhang, and Ling Yang. "Expression of IkappaB Family in the Ovine Liver during Early Pregnancy." Animals 13, no. 6 (2023): 1057. http://dx.doi.org/10.3390/ani13061057.

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During normal pregnancy, there is a dynamic regulation of the maternal immune system, including the liver, to accommodate the presence of the allogeneic foetus in the uterus. However, it was unclear that the expression of the IkappaB (IκB) family was regulated in the ovine maternal liver during early pregnancy. In this study, sheep livers were collected at day 16 of the oestrous cycle (NP16), and days 13, 16 and 25 of gestation (DP13, DP16 and DP25), and RT-qPCR, Western blot and immunohistochemistry analysis were used to analyse the expression of the IκB family, including B cell leukemia-3 (B

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Ahmed, Md Mahiuddin, Aaron Block, Nicolas Busquet, and Katheleen J. Gardiner. "Context Fear Conditioning in Down Syndrome Mouse Models: Effects of Trisomic Gene Content, Age, Sex and Genetic Background." Genes 12, no. 10 (2021): 1528. http://dx.doi.org/10.3390/genes12101528.

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Down syndrome (DS), trisomy of the long arm of human chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability (ID). Currently, there are no effective pharmacotherapies. The success of clinical trials to improve cognition depends in part on the design of preclinical evaluations in mouse models. To broaden understanding of the common limitations of experiments in learning and memory, we report performance in context fear conditioning (CFC) in three mouse models of DS, the Dp(16)1Yey, Dp(17)1Yey and Dp(10)1Yey (abbreviated Dp16, Dp17 and Dp10), separately trisomic for th

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Hattori, T., H. Komoda, S. Pahwa, et al. "Decline of anti-DP107 antibody associated with clinical progression." AIDS 12, no. 12 (1998): 1557–59. http://dx.doi.org/10.1097/00002030-199812000-00023.

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Guo, Xu, Guanghao Li, Xiangpeng Ding, et al. "Response of Leaf Senescence, Photosynthetic Characteristics, and Yield of Summer Maize to Controlled-Release Urea-Based Application Depth." Agronomy 12, no. 3 (2022): 687. http://dx.doi.org/10.3390/agronomy12030687.

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To explore the response of summer maize leaf senescence, photosynthetic characteristics, and yield to the depth of one-time base application of controlled-release urea, which provides a theoretical basis for the light and simplified production of summer maize. Seven treatments were set up with Zhengdan 958 as the material under field conditions, including no nitrogen fertilizer (CK), surface spreading (DP0), furrow application depth of 5 cm (DP5), 10 cm (DP10), 15 cm (DP15), 20 cm (DP20), 25 cm (DP25). The results showed that under the same nitrogen application rate, there are significant diff

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Margot, Jean-Luc. "Minor Planet Binaries." Highlights of Astronomy 13 (2005): 760. http://dx.doi.org/10.1017/s1539299600017056.

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The first detailed characterization of a near-Earth binary (2000 DP107) provided significant insights into the formation mechanism, orbital evolution, and physical properties of the system. Near-Earth Asteroid (NEA) binaries are tidally evolved with synchronously rotating secondaries, providing constraints on asteroid mechanical properties (tidal Q and rigidity). It is expected that radar observations will permit measurements of orbital precession, with corresponding implications for the distribution of mass within asteroids.

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Rosner, Marsha R., Karol L. Thompson, J. Victor Garcia, and M. Patrizia Stoppelli. "4774321 DP100 EGF and insulin-binding protein from drosophila cells." Progress in Growth Factor Research 1, no. 4 (1989): 283. http://dx.doi.org/10.1016/0955-2235(89)90026-4.

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Bingham, Max. "Timely News and Notes for Primary Care Providers from the American Diabetes Association." Clinical Diabetes 40, no. 3 (2022): 259–63. http://dx.doi.org/10.2337/cd22-dp03.

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Bingham, Max. "Timely News and Notes for Primary Care Providers from the American Diabetes Association." Clinical Diabetes 38, no. 3 (2020): iv—viii. http://dx.doi.org/10.2337/cd20-dp03.

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Bingham, Max. "Timely News and Notes for Primary Care Providers from the American Diabetes Association." Clinical Diabetes 39, no. 3 (2021): 244–48. http://dx.doi.org/10.2337/cd21-dp03.

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Bingham, Max. "Timely News and Notes for Primary Care Providers from the American Diabetes Association." Clinical Diabetes 41, no. 3 (2023): 332–36. http://dx.doi.org/10.2337/cd23-dp03.

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Al Ouahabi, Abdelaziz, Mitsuharu Kotera, Laurence Charles, and Jean-François Lutz. "Synthesis of Monodisperse Sequence-Coded Polymers with Chain Lengths above DP100." ACS Macro Letters 4, no. 10 (2015): 1077–80. http://dx.doi.org/10.1021/acsmacrolett.5b00606.

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Yang, B., J. Zhu, J. Gao, H. T. Zhang, and X. Z. Zheng. "Observations of 2000 DP107 in NAOC: rotation period and reflectance spectrum." Planetary and Space Science 51, no. 6 (2003): 411–14. http://dx.doi.org/10.1016/s0032-0633(03)00024-2.

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Harvey, CJ, MJ O'Doherty, CJ Page, SH Thomas, TO Nunan, and DF Treacher. "Comparison of jet and ultrasonic nebulizer pulmonary aerosol deposition during mechanical ventilation." European Respiratory Journal 10, no. 4 (1997): 905–9. http://dx.doi.org/10.1183/09031936.97.10040905.

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Increased delivery of aerosol to a model lung (attached to a mechanical ventilator) has been demonstrated with an ultrasonic nebulizer as compared to a jet nebulizer. This study examined whether the increased aerosol deposition with an ultrasonic nebulizer could also be demonstrated in vivo. Seven patients (6 male and 1 female) were studied during mechanical ventilalion (Siemens Servo 900C, Middlesex, UK) after open heart surgery. Two studies were performed in each patient. In the first study, aerosol was delivered via a Siemens Servo 945 nebulizer system (high setting) driving a System 22 Aco

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Naidu, S. P., J. L. Margot, P. A. Taylor, et al. "RADAR IMAGING AND CHARACTERIZATION OF THE BINARY NEAR-EARTH ASTEROID (185851) 2000 DP107." Astronomical Journal 150, no. 2 (2015): 54. http://dx.doi.org/10.1088/0004-6256/150/2/54.

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Duclos-Cianci, Guillaume, and David Poulin. "Fault-tolerant renormalization group decoder for abelian topological codes." Quantum Information and Computation 14, no. 9&10 (2014): 721–40. http://dx.doi.org/10.26421/qic14.9-10-1.

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We present a three-dimensional generalization of a renormalization group decoding algorithm for topological codes with Abelian anyonic excitations that we introduced for two dimensions in \cite{DP09a,DP10a}. We also provide a complete detailed description of the structure of the algorithm, which should be sufficient for anyone interested in implementing it. This 3D implementation extends our previous 2D algorithm by incorporating a failure probability of the syndrome measurements, i.e., it enables fault-tolerant decoding. We report a fault-tolerant storage threshold of $\sim1.9(4)\%$ for Kitae

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Stephenson, Ethan W., Joel M. DeRouchey, J. Escobar, et al. "Effects of a novel protease enzyme (CIBENZA DP100) on finishing pig growth performance and carcass characteristics." Kansas Agricultural Experiment Station Research Reports, no. 10 (January 1, 2014): 69–76. http://dx.doi.org/10.4148/2378-5977.6912.

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Guckian, Jonathan, Bipin Mathew, Will Merchant, Andrew Muinonen-Martin, Angana Mitra, and Hayley Smith. "DP13 First case of distant metastases from a BAP1-inactivated melanocytoma with melanoma transformation." British Journal of Dermatology 191, Supplement_1 (2024): i112—i113. http://dx.doi.org/10.1093/bjd/ljae090.235.

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Abstract A 43-year-old man presented with a long-standing back lesion causing irritation and bleeding. A presumed pedunculated seborrhoeic keratosis was shave excised by his general practitioner; however, histology revealed a BRCA1-associated protein (BAP1)-inactivated melanocytoma (BIM) with melanoma transformation. Histologically, BIMs are identified by the presence of a dermally located expansile clone of epithelioid melanocytes, sometimes associated with a pre-existent conventional naevus. Clones have abundant amphophilic cytoplasm and nuclear polymorphism with distinct cell membranes. BAP

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Chen, Tong, Wei-Ping Gai, and Catherine A. Abbott. "P1-374: Altered expression of the potassium channel-associated protein DP10 in Alzheimer's disease." Alzheimer's & Dementia 6 (July 2010): S281. http://dx.doi.org/10.1016/j.jalz.2010.05.928.

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Clarke, Emily L., Derek Magee, Julia Newton-Bishop, et al. "DP03 Melanoma detection in whole-slide images using a convolutional neural network for objective prognostic biomarker generation." British Journal of Dermatology 191, Supplement_1 (2024): i108. http://dx.doi.org/10.1093/bjd/ljae090.225.

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Abstract The current melanoma staging system is predictive of 74% of the variance in survival, with prognostic biomarkers subject to high levels of interobserver and intraobserver variation. Melanoma morphology appears to be of greater significance than in other solid tumours, with Breslow thickness remaining the strongest prognostic indicator. The application of convolutional neural networks (CNNs) to whole-slide images (WSIs) may reveal new insights into tumour morphology and therefore patient prognosis. This work outlines the development and evaluation of a CNN for invasive cutaneous melano

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Hook, Darla D., and Catherine Gebhart. "P037 Pre-transplant HLA DP10 donor specific antibody of unknown significance in heart transplant a case study." Human Immunology 79 (October 2018): 87. http://dx.doi.org/10.1016/j.humimm.2018.07.095.

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Gaschet, J., MA Trevino, M. Cherel, et al. "HLA-target antigens and T-cell receptor diversity of activated T cells invading the skin during acute graft-versus-host disease." Blood 87, no. 6 (1996): 2345–53. http://dx.doi.org/10.1182/blood.v87.6.2345.bloodjournal8762345.

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To study the repertoire and specificity of T lymphocytes infiltrating skin lesions during graft-versus-host disease (GVHD), we performed an exhaustive molecular and functional analysis of 146 T-cell clones derived from the skin of three patients undergoing an acute GVHD after allogeneic bone marrow transplantation (BMT) from HLA-mismatched related donors. Analysis of T-cell receptor (TCR) rearrangement and TCR chain junctional sequences demonstrated the presence of 11 distinct clones among the 64 derived from patient UPN1, six among the 58 derived from patient UPN2, and seven among the 24 deri

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Gandra, Jefferson R., Rafael M. Mattos, Thais M. D. M. Soares, et al. "Rehydrated Corn Grain Silage and Exogenous Protease: Effects on Dairy Cow Performance, Metabolism, and Starch Digestibility." Dairy 6, no. 1 (2024): 1. https://doi.org/10.3390/dairy6010001.

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Twenty-four Girolando cows (107 ± 56 days in milk, milk yield 22.0 ± 10.25 kg/d, and 529 ± 103 kg body weight) were used in a completely randomized design. The cows were divided according to the following experimental diets: 1—CON (basal diet with ground dry corn) 2—RCS (diet with total replacement of ground corn by rehydrated corn grain silage) 3—RCSP (diet with total replacement of ground corn by rehydrated corn grain silage + 500 g ton−1 of CINBENZA DP100®, NOVUS International, Inc (Chesterfield, Missouri, U.S.A.). enzymatic extract of Bacillus licheniformis, protease activity 600 IU g−1).

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Patel, Shrusti S., Ella N. Hoogenboezem, Fang Yu, et al. "Abstract 2706: Therapeutic silencing of Rictor using siRNA nanoparticles to selectively block mTORC2 signaling in triple negative breast cancer." Cancer Research 83, no. 7_Supplement (2023): 2706. http://dx.doi.org/10.1158/1538-7445.am2023-2706.

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Abstract Triple negative breast cancers (TNBCs) are aggressive malignancies with a high rate of recurrence even after neoadjuvant chemotherapy (NAC) and resection. Nearly 50% of NAC-treated TNBC patients harboring residual disease display mutations in the phosphatidyl inositol-3 kinase/mechanistic target of rapamycin (PI3K/mTOR) pathway, correlating PI3K/mTOR with chemoresistance. The protein kinase mTOR functions within two distinct protein complexes—mTORC1 and mTORC2. Inhibition of mTORC1 is ineffective in TNBCs. However, less is known regarding mTORC2 as a TNBC drug target, though mTORC2 is

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Gunawan, I. Wayan Nico Fajar, Putu Devi Jayanti, Anak Agung Gde Oka Dharmayudha, Wayan Sukernayasa, and I. Ketut Puja. "Ultrasonography Examination of the Kidney in Bali Cattle." World's Veterinary Journal 14, no. 2 (2024): 228–33. http://dx.doi.org/10.54203/scil.2024.wvj28.

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Ultrasonography is an important technology for examining renal measurements, including length and width. The kidneys can be easily examined, and various structures in the kidneys are distinguishable with ultrasound. This research aimed to determine the normal ultrasonographic appearance of the kidneys in healthy adult Bali cattle, providing a reference for future descriptions of Bali cattle kidneys. In this research, 8 Bali cattle, aged 2-3 years with the healthy status of the urinary system were examined. The tool used was an animal ultrasound device, named Mindray DP10 Veterinary Ultrasound,

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Vasileiadou, Athina, Ioannis Sampsonidis, Georgios Theodoridis, Anastasia Zotou, Ioannis Karapanagiotis, and Stavros Kalogiannis. "Identification of Degradation Products and Components in Shellfish Purple by Ultrahigh Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry." Heritage 7, no. 4 (2024): 1935–46. http://dx.doi.org/10.3390/heritage7040092.

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Ultrahigh performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) was used to analyze a colorant and silk, which were prepared and dyed using shellfish (Hexaplex trunculus L.) purple. Solutions of colorant and silk extracts were analyzed immediately after preparation (fresh samples) and after storing them in the dark for thirty days (aged sample I). Moreover, a silk sample was subjected to artificially accelerated ageing under UV radiation (aged sample II). The application of the UHPLC-MS/MS method leads to the detection of (i) the major coloring components of shell

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Berthalon, Steve, Jérémy Frugier, Nathalie Azema, Claire Negrell, and Ghislain David. "Concentrated O/W Emulsion Stability of Non-Ionic Chitosan Oligomer Surfactants Modified by Epoxidized Fatty Chains at pH7: Influence of Emulsification Conditions." Polysaccharides 5, no. 2 (2024): 67–84. http://dx.doi.org/10.3390/polysaccharides5020005.

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In this study, chitosan-based surfactants were synthesized by epoxy–amine chemistry to stabilize concentrated O/W emulsions at pH7. Chitosan was first depolymerized by nitrous deamination to obtain chitooligosaccharides (COS) with degrees of polymerization of 10 (DP10) and 20 (DP20). Then, three different epoxidized fatty chains, i.e., octyl/decyl glycidyl ether (C9), hexadecyl glycidyl ether (C16) and epoxidized cardanol (card), were grafted onto the amine groups of chitosan to form six amphiphilic structures. NMR measurements revealed grafting efficiencies ranging from 1 to 30% while HLB val

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