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Journal articles on the topic 'DPA-713'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ordonez, Alvaro A., Supriya Pokkali, Vincent P. DeMarco, et al. "Radioiodinated DPA-713 Imaging Correlates with Bactericidal Activity of Tuberculosis Treatments in Mice." Antimicrobial Agents and Chemotherapy 59, no. 1 (2014): 642–49. http://dx.doi.org/10.1128/aac.04180-14.

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ABSTRACTCurrent tools for monitoring response to tuberculosis treatments have several limitations. Noninvasive biomarkers could accelerate tuberculosis drug development and clinical studies, but to date little progress has been made in developing new imaging technologies for this application. In this study, we developed pulmonary single-photon emission computed tomography (SPECT) using radioiodinated DPA-713 to serially monitor the activity of tuberculosis treatments in live mice, which develop necrotic granulomas and cavitary lesions. C3HeB/FeJ mice were aerosol infected withMycobacterium tub

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2

Kobayashi, Masato, Teresa Jiang, Sanjay Telu, et al. "11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-(R)-PK11195." Journal of Cerebral Blood Flow & Metabolism 38, no. 3 (2017): 393–403. http://dx.doi.org/10.1177/0271678x17699223.

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Positron emission tomography (PET) radioligands for translocator protein 18 kDa (TSPO) are widely used to measure neuroinflammation, but controversy exists whether second-generation radioligands are superior to the prototypical agent 11C-( R)-PK11195 in human imaging. This study sought to quantitatively measure the “signal to background” ratio (assessed as binding potential ( BPND)) of 11C-( R)-PK11195 compared to one of the most promising second-generation radioligands, 11C-DPA-713. Healthy subjects had dynamic PET scans and arterial blood measurements of radioligand after injection of either

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Cerutti, Erika, Annelaure Damont, Frédéric Dollé, Simona Baroni, and Silvio Aime. "Synthesis and characterization of an MRI Gd-based probe designed to target the translocator protein." Magnetic Resonance in Chemistry 51, no. 2 (2013): 116–22. https://doi.org/10.1002/mrc.3919.

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DPA-713 is the lead compound of a recently reported pyrazolo[1,5-a]pyrimidineacetamide series, targeting the translocator protein (TSPO 18 kDa), and as such, this structure, as well as closely related derivatives, have been already successfully used as positron emission tomography radioligands. On the basis of the pharmacological core of this ligands series, a new magnetic resonance imaging probe, coded DPA-C(6)-(Gd)DOTAMA was designed and successfully synthesized in six steps and 13% overall yield from DPA-713. The Gd-DOTA monoamide cage (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraac

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Werry, Eryn L., Victoria A. King, Melissa L. Barron, Samuel D. Banister, Renee Sokias, and Michael Kassiou. "Derivatives of the pyrazolo[1,5-a]pyrimidine acetamide DPA-713 as translocator protein (TSPO) ligands and pro-apoptotic agents in human glioblastoma." European Journal of Pharmaceutical Sciences 96 (September 19, 2016): 186–92. https://doi.org/10.1016/j.ejps.2016.09.026.

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The 18kDa translocator protein (TSPO) is a target for novel glioblastoma therapies due to its upregulation in this cancer and relatively low levels of expression in the healthy cortex. The pyrazolo[1,5-a]pyrimidine acetamides, exemplified by DPA-713 and DPA-714, are a class of high affinity TSPO ligands with selectivity over the central benzodiazepine receptor. In this study we have explored the potential anti-glioblastoma activity of a library of DPA-713 and DPA-714 analogues, and investigated the effect of amending the alkyl ether chain on TSPO affinity and functional potential. All ligands

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Yaqub, Maqsood, Nicki J. F. Verweij, Simone Pieplenbosch, Ronald Boellaard, Adriaan A. Lammertsma, and Conny J. van der Laken. "Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [11C]DPA-713 Positron Emission Tomography." International Journal of Molecular Sciences 21, no. 9 (2020): 3137. http://dx.doi.org/10.3390/ijms21093137.

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Treatment for rheumatoid arthritis (RA) should be started as early as possible to prevent destruction of bone and cartilage in affected joints. A new diagnostic tool for both early diagnosis and therapy monitoring would be valuable to reduce permanent joint damage. Positron emission tomography (PET) imaging of macrophages is a previously demonstrated non-invasive means to visualize (sub)clinical arthritis in RA patients. We developed a kinetic model to quantify uptake of the macrophage tracer [11C]DPA-713 (N,N-diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethylpyrazolo [1,5-a]pyrimidin-3-yl]acetamide)

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Rubin, Leah H., Yong Du, Shannon Eileen Sweeney, et al. "Imaging Brain Injury in Former National Football League Players." JAMA Network Open 6, no. 10 (2023): e2340580. http://dx.doi.org/10.1001/jamanetworkopen.2023.40580.

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ImportancePilot studies that involved early imaging of the 18 kDa translocator protein (TSPO) using positron emission tomography (PET) indicated high levels of TSPO in the brains of active or former National Football League (NFL) players. If validated further in larger studies, those findings may have implications for athletes involved in collision sport.ObjectiveTo test for higher TSPO that marks brain injury and repair in a relatively large, unique cohort of former NFL players compared with former elite, noncollision sport athletes.Design, Setting, and ParticipantsThis cross-sectional study

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7

Banister, Samuel D., Corinne Beinat, Shane M. Wilkinson, et al. "Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO)." Eur J Med Chem. 93 (February 7, 2015): 392–400. https://doi.org/10.1016/j.ejmech.2015.02.004.

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Sixteen new phenyl alkyl ether derivatives (12, 14-28) of the 5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylacetamide (DPA) class were synthesized and evaluated in a competition binding assay against [3H]PK11195 using 18 kDa translocator protein (TSPO) derived from rat kidney mitochondrial fractions. All analogues showed superior binding affinities for TSPO compared to DPA-713 (5) and DPA-714 (6). Picomolar affinities were observed for this class of TSPO ligands in this assay for the first time, with phenethyl ether 28 showing the greatest affinity (Ki = 0.13 nM). Additiona

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8

Wilson, Thomas C., Greg McSweeney, Sean Preshlock, et al. "Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of (hetero)aryl boron reagents." Chemical Communications 52, no. 90 (2016): 13277–80. http://dx.doi.org/10.1039/c6cc07417k.

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The Cu-mediated [<sup>123</sup>I]iodination of aryl boronic pinacol esters and acids exhibits broad scope and is successfully applied to the labelling of four radiotracers, [<sup>123</sup>I]DPA-713, [<sup>123</sup>I]IMPY, [<sup>123</sup>I]MIBG and [<sup>123</sup>I]IPEB.

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Foss, Catherine A., Jamie S. Harper, Haofan Wang, Martin G. Pomper, and Sanjay K. Jain. "Noninvasive Molecular Imaging of Tuberculosis-Associated Inflammation With Radioiodinated DPA-713." Journal of Infectious Diseases 208, no. 12 (2013): 2067–74. http://dx.doi.org/10.1093/infdis/jit331.

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Damont, Annelaure, Sébastien Garcia-Argote, David-Alexandre Buisson, Bernard Rousseau, and Frédéric Dollé. "Efficient tritiation of the translocator protein (18kDa) selective ligand DPA-714." J Labelled Comp Radiopharm. 58, no. 1 (2015): 1–6. https://doi.org/10.1002/jlcr.3252.

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DPA-714 (N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide) is a recently discovered fluorinated ligand of the translocator protein 18 kDa (TSPO). Labelled with the short-lived positron emitter fluorine-18, this structure is today the radioligand of reference for in vivo imaging of microglia activation and neuroinflammatory processes with positron emission tomography. In the present work, an isotopically tritium-labelled version was developed ([3H]DPA-714), in order to access high resolution in vitro and ex vivo microscopic auto

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Endres, C. J., M. G. Pomper, M. James, et al. "Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans." Journal of Nuclear Medicine 50, no. 8 (2009): 1276–82. http://dx.doi.org/10.2967/jnumed.109.062265.

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Endres, C. J., J. M. Coughlin, K. L. Gage, C. C. Watkins, M. Kassiou, and M. G. Pomper. "Radiation Dosimetry and Biodistribution of the TSPO Ligand 11C-DPA-713 in Humans." Journal of Nuclear Medicine 53, no. 2 (2012): 330–35. http://dx.doi.org/10.2967/jnumed.111.094565.

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13

Yasuno, Fumihiko, Yasuyuki Kimura, Aya Ogata, et al. "Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713." Nuclear Medicine and Biology 108-109 (May 2022): 76–84. http://dx.doi.org/10.1016/j.nucmedbio.2022.02.005.

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14

Sanchez-Bautista, Julian, Catherine A. Foss, Alvaro A. Ordonez, Mariah H. Klunk, and Sanjay K. Jain. "Imaging Pulmonary Foreign Body Reaction Using [125I]iodo-DPA-713 SPECT/CT in Mice." Molecular Imaging and Biology 21, no. 2 (2018): 228–31. http://dx.doi.org/10.1007/s11307-018-1249-0.

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15

Wang, Yuchuan, Jennifer M. Coughlin, Shuangchao Ma, et al. "Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography." Lupus 26, no. 2 (2016): 170–78. http://dx.doi.org/10.1177/0961203316657432.

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Objective Inflammation secondary to autoantibody-mediated effects occurring in multiple organs is a hallmark of systemic lupus erythematosus (SLE). The inflammatory response to SLE-mediated damage in brain parenchyma has been postulated in both normal and cognitively impaired individuals. Our goal is to use molecular imaging to investigate the distribution within the brain of the mitochondrial translocator protein (TSPO) that is upregulated during glial cell activation, and is considered as a marker of brain injury and repair. Methods We sought to characterize TSPO distribution in the brain of

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Chauveau, F., N. Van Camp, F. Dolle, et al. "Comparative Evaluation of the Translocator Protein Radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a Rat Model of Acute Neuroinflammation." Journal of Nuclear Medicine 50, no. 3 (2009): 468–76. http://dx.doi.org/10.2967/jnumed.108.058669.

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Foss, Catherine A., Donika Plyku, Alvaro A. Ordonez, et al. "Biodistribution and Radiation Dosimetry of 124I-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation." Journal of Nuclear Medicine 59, no. 11 (2018): 1751–56. http://dx.doi.org/10.2967/jnumed.117.207431.

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Rosenberg, Paul B., Constantine G. Lyketsos, Chris Endres, Dima Hammoud, and Martin Pomper. "P4-172: Pet imaging of translocator protein (TSPO) in elderly controls using [11C]DPA-713." Alzheimer's & Dementia 5, no. 4S_Part_16 (2009): P482. http://dx.doi.org/10.1016/j.jalz.2009.04.739.

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19

Thominiaux, C., F. Dollé, M. L. James, et al. "Improved synthesis of the peripheral benzodiazepine receptor ligand [11C]DPA-713 using [11C]methyl triflate." Applied Radiation and Isotopes 64, no. 5 (2006): 570–73. http://dx.doi.org/10.1016/j.apradiso.2005.12.003.

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20

J, K. Nag, Chattopadhyay P., K. Misra T., and Sinha C. "Dioxouranium complexes of 2,2' -dihydroxyazobenzene : Binding of mono- and bidentate Lewis bases." Journal of Indian Chemical Society Vol. 77, Jun 2000 (2000): 270–72. https://doi.org/10.5281/zenodo.5868766.

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Department of Chemistry, Burdwan University, Burdwan-713 104, India <em>Manuscript received 7 July 1999. revised 4 January 2000. accepted 26 February 2000</em> Uranyl complexes of 2,2'-dihydroxyazobcnzenc (H<sub>2</sub>L) and its adducts with monodentate (B) and bidentate (B-B) Lewis bases of the type [UO<sub>2</sub>L.B.H<sub>2</sub>O] (B= py, \(\gamma\)-pic, imz, dmf, dmso, tppo) and<strong> </strong>[UO<sub>2</sub>L(B-B)] (B-B = bpy, ophen, dpa) are described. The complexes arc pentagonal hipyramidal. The live coordination positions on the equator arc occupied by the combination of ligan

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Boutin, H., F. Chauveau, C. Thominiaux, et al. "11C-DPA-713: A Novel Peripheral Benzodiazepine Receptor PET Ligand for In Vivo Imaging of Neuroinflammation." Journal of Nuclear Medicine 48, no. 4 (2007): 573–81. http://dx.doi.org/10.2967/jnumed.106.036764.

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22

Foss, Catherine A., Liansheng Liu, Ronnie C. Mease, Haofan Wang, Pankaj Pasricha, and Martin G. Pomper. "Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with125I-Iodo-DPA-713 SPECT/CT." Journal of Nuclear Medicine 58, no. 10 (2017): 1685–90. http://dx.doi.org/10.2967/jnumed.117.189571.

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Coughlin, Jennifer M., Yuchuan Wang, Shuangchao Ma, et al. "Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV." Journal of NeuroVirology 20, no. 3 (2014): 219–32. http://dx.doi.org/10.1007/s13365-014-0239-5.

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Kameno, *Yosuke, Masamichi Yokokura, Toshiki Iwabuchi, et al. "TESTING NEUROINFLAMMATORY HYPOTHESIS OF MAJOR DEPRESSIVE DISORDER: A DOUBLE TRACER PET STUDY." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i135—i136. https://doi.org/10.1093/ijnp/pyae059.235.

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Abstract Background Although the pathophysiology of major depressive disorder (MDD) still remains unclear, one of the promising hypotheses is the neuroinflammation hypothesis. [1] In this hypothesis, activated microglia secrete pro-inflammatory cytokines such as TNF-α and IL-1β in the brain of patients with MDD. These cytokines lead to activate serotonin transporter (5-HTT) and indoleamine 2,3-dioxygenase (IDO), decreasing the concentration of serotonin in the synaptic cleft, resulting in depressive state. However, to the best of our knowledge, no previous study tested the association between

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Binsbergen, W., J. De Jongh, S. Pieplenbosch, et al. "POS0153 MACROPHAGE [11C]-DPA-713 PET-CT IMAGING TO PREDICT EARLY ANTI-TNF TREATMENT OUTCOME IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 298.1–298. http://dx.doi.org/10.1136/annrheumdis-2023-eular.420.

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BackgroundTreatment of rheumatoid arthritis (RA) using anti-tumor necrosis factor (TNF) biologics has greatly benefited patients since their introduction, with an expected treatment response rate of up to 50-70% [1]. This however, leaves 30-50% of patients taking ineffective medication whilst being exposed to the potential side-effects of anti-TNF. Current patient care requires clinical evaluation of 3 to 6 months before effectiveness can reliably be assessed. Quantitative macrophage positron emission tomography (PET) has shown potential to predict clinical response at an early stage of treatm

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Damont, Annelaure, Dirk Roeda, and Frédéric Dollé. "The potential of carbon-11 and fluorine-18 chemistry: Illustration through the development of PET-radioligands targeting the TSPO 18 kDa." J Labelled Comp Radiopharm. 56, no. 3-4 (2013): 96–104. https://doi.org/10.1002/jlcr.2992.

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The TSPO (translocator protein), also known as the peripheral benzodiazepine receptor, is upregulated in the brain of subjects suffering from neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's disease. Moreover, this overexpression has been proved to be linked to microglia activation making thus the TSPO a marker of choice of neuroinflammatory processes and therefore a potential target for the development of radioligands for positron emission tomography imaging. The discovery of selective TSPO ligands and their labelling with the short-lived positron-emit

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Rosenberg, Paul, Christopher Endres, Constantine Lyketsos, Jennifer Coughlin, Michael Kassiou, and Martin Pomper. "P4-070: Quantifying translocator protein (TSPO) in Alzheimer's disease and cognitively healthy older persons with 11C-DPA-713 PET imaging." Alzheimer's & Dementia 7 (July 2011): S725. http://dx.doi.org/10.1016/j.jalz.2011.05.2091.

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Werry, Eryn L., Victoria A. King, Melissa L. Barron, Samuel D. Banister, Renee Sokias, and Michael Kassiou. "Derivatives of the pyrazolo[1,5- a ]pyrimidine acetamide DPA-713 as translocator protein (TSPO) ligands and pro-apoptotic agents in human glioblastoma." European Journal of Pharmaceutical Sciences 96 (January 2017): 186–92. http://dx.doi.org/10.1016/j.ejps.2016.09.026.

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Coughlin, J. M., Y. Wang, E. B. Ambinder, et al. "In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C]DPA-713 PET and analysis of CSF and plasma." Translational Psychiatry 6, no. 4 (2016): e777-e777. http://dx.doi.org/10.1038/tp.2016.40.

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Cerutti, Erika, Alessandra Viale, Annelaure Damont, Frédéric Dollé, and Silvio Aime. "Synthesis and testing of a p-H2 hyperpolarized 13 C probe based on the pyrazolo[1,5-a ]pyrimidineacetamide DPA-713, an MRI vector to target the peripheral benzodiazepine receptors." Magnetic Resonance in Chemistry 49, no. 12 (2011): 795–800. http://dx.doi.org/10.1002/mrc.2839.

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Chaney, Aisling, Haley C. Cropper, Emily M. Johnson, et al. "11C-DPA-713 Versus 18F-GE-180: A Preclinical Comparison of Translocator Protein 18 kDa PET Tracers to Visualize Acute and Chronic Neuroinflammation in a Mouse Model of Ischemic Stroke." Journal of Nuclear Medicine 60, no. 1 (2018): 122–28. http://dx.doi.org/10.2967/jnumed.118.209155.

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Ruiz-Bedoya, Camilo A., Filipa Mota, Elizabeth Tucker, et al. "191. High-Dose Rifampin-containing Regimens for the Treatment of TB Meningitis." Open Forum Infectious Diseases 8, Supplement_1 (2021): S115—S116. http://dx.doi.org/10.1093/ofid/ofab466.191.

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Abstract Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day) is safe in adults and substantially improves the bactericidal activity of standard TB regimen. However, there is conflicting data regarding its benefit in TB meningitis where outcomes may also be associated with intracerebral inflammatory responses. Methods A novel mouse and a validated rabbit model of TB meningitis utilizing intracranial Mycobacterium tuberculosis infections were used for these studies (Fig. 1). Animals received high-do

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Foss, Catherine A., Flonné Wildes, Delia Mezzanzanica, et al. "Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer." EJNMMI Research 14, no. 1 (2024). http://dx.doi.org/10.1186/s13550-024-01157-8.

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Abstract Background Tumor-Associated Macrophages (TAMs) play a critical role in the pathogenesis and progression of ovarian cancer, a lethal gynecologic malignancy. [124I]iodo-DPA-713 is a PET radiotracer that is selectively trapped within reactive macrophages. We have employed this radioligand here as well as a fluorescent analog to image TAMs associated with primary tumors, secondary pulmonary metastases and gastrointestinal tract-associated macrophages, associated with ascites accumulation in a syngeneic mouse model of metastatic ovarian cancer. Intact female C57BL/6 mice were engrafted wit

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Rubin, Leah H., Pauline M. Maki, Yong Du, et al. "Imaging the translocator protein 18 kDa within cognitive control and declarative memory circuits in virally-suppressed people with HIV." AIDS, October 11, 2024. http://dx.doi.org/10.1097/qad.0000000000004034.

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Objectives: Virally-suppressed people with HIV (VS-PWH) show heterogeneity in patterns of cognitive dysfunction. To better understand the relationship between the neuroimmune response and cognition, we used positron emission tomography (PET) to image the translocator protein 18 kDa (TSPO). The study examined HIV-serostatus differences in TSPO as well as associations between regional TSPO and select cognitive processes defined using the Research Domain Criteria (RDoC) framework. Design: Cross-sectional investigation in VS-PWH (n = 25) versus HIV-uninfected individuals (n = 18) of cognitive cont

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Akerele, Mercy I., Sara A. Zein, Sneha Pandya, et al. "Population-based input function for TSPO quantification and kinetic modeling with [11C]-DPA-713." EJNMMI Physics 8, no. 1 (2021). http://dx.doi.org/10.1186/s40658-021-00381-8.

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Abstract Introduction Quantitative positron emission tomography (PET) studies of neurodegenerative diseases typically require the measurement of arterial input functions (AIF), an invasive and risky procedure. This study aims to assess the reproducibility of [11C]DPA-713 PET kinetic analysis using population-based input function (PBIF). The final goal is to possibly eliminate the need for AIF. Materials and methods Eighteen subjects including six healthy volunteers (HV) and twelve Parkinson disease (PD) subjects from two [11C]-DPA-713 PET studies were included. Each subject underwent 90 min of

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Ruiz-Bedoya, Camilo A., Filipa Mota, Alvaro A. Ordonez, et al. "124I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection." Molecular Imaging and Biology, August 23, 2021. http://dx.doi.org/10.1007/s11307-021-01638-5.

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Doorduin, Janine, Hans C. Klein, Rudi A. Dierckx, Michelle James, Michael Kassiou, and Erik F. J. de Vries. "[11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis." Molecular Imaging and Biology 11, no. 6 (2009). http://dx.doi.org/10.1007/s11307-009-0211-6.

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Chaney, Aisling M., Emily M. Johnson, Haley C. Cropper, and Michelle L. James. "PET Imaging of Neuroinflammation Using [¹¹C]DPA-713 in a Mouse Model of Ischemic Stroke." Journal of Visualized Experiments, no. 136 (June 14, 2018). http://dx.doi.org/10.3791/57243.

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Coughlin, Jennifer M., Ting Yang, Alison W. Rebman, et al. "Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET." Journal of Neuroinflammation 15, no. 1 (2018). http://dx.doi.org/10.1186/s12974-018-1381-4.

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Lee, Youjin, Thanh D. Nguyen, Yong Du, et al. "Validating the Utility of Supervised Clustering Algorithm for Precise [¹¹C]DPA-713 PET Brain Image Quantification." Journal of Nuclear Medicine, April 3, 2025, jnumed.124.268519. https://doi.org/10.2967/jnumed.124.268519.

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Mahmud, Farina J., Yong Du, Elizabeth Greif, et al. "Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection." Journal of Neuroinflammation 17, no. 1 (2020). http://dx.doi.org/10.1186/s12974-020-01949-4.

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Abstract Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the neuropathologic hallmarks of neurodegenerative disease, but understanding of the molecular mechanisms remains in several contexts poorly understood. Methods Micro-positron emission tomography (PET) neuroimaging using radioligands to detect increased expression of the translocator protein (TSPO) receptor in the brain is a non-invasive tool used to track neuroinflammation

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Fujita, Masahiro, Masato Kobayashi, Masamichi Ikawa, et al. "Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios." EJNMMI Research 7, no. 1 (2017). http://dx.doi.org/10.1186/s13550-017-0334-8.

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Perez, Daniel Andres Martinez, Jennifer L. McGlothan та Tomás R. Guilarte. "Age‐ and Sex‐ dependent changes in Translocator Protein 18 kDa (TSPO) expression, cellular sources, and association with amyloid‐β plaques in the 5XFAD murine model of Alzheimer’s Disease". Alzheimer's & Dementia 19, S13 (2023). http://dx.doi.org/10.1002/alz.078088.

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AbstractBackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder that affects cognition, memory, and social abilities with devastating effects on individuals and families. The hallmark AD pathology is the formation of amyloid‐β‐(Aβ)‐plaques and Tau neurofibrillary tangles leading to neurodegeneration. Neuroinflammation, and microglia activation, also play an important role in the initiation and progression of AD, a process that begins earlier than cognitive decline. TSPO is a well‐validated and widely used biomarker of neuroinflammation that is expressed in glial cells, and it is mar

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Palenik, Chris S., and Rodney C. Ewing. "Microanalysis of Radiation Damage Across a Zoned Zircon Crystal." MRS Proceedings 713 (2002). http://dx.doi.org/10.1557/proc-713-jj8.8.

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ABSTRACTAn oscillatory-zoned single crystal of zircon (ZrSiO4) from Sri Lanka (560 Ma) provides a unique opportunity to study radiation effects over the dose range of 2.1 - 10.6·1015 á-decay events/mg (0.1 - 0.5 dpa). Each zone has a different radiation dose due to variations in the U (0.09 - 0.53 wt %) and Th (0 - 0.11 wt %) content, but all zones share the same thermal history. The zones span a nearly complete range of microstructures from crystalline to aperiodic. Measurements of birefringence show an inverse-linear correlation with dose over the range of doses observed. Micro-Raman spectro

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Lian, J., L. M. Wang, J. Chen, R. C. Ewing, and K. V. G. Kutty. "Heavy Ion Irradiation of Zirconate Pyrochlores." MRS Proceedings 713 (2002). http://dx.doi.org/10.1557/proc-713-jj11.35.

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Abstract:

ABSTRACTZirconate pyrochlores, A2Zr2O7, are important potential nuclear waste forms for Puimmobilization. The binary Gd2(Ti2-xZrx)O7 has been shown to have increasing resistance to ionirradiation damage with the increasing Zr content, and Gd2Zr2O7 is radiation resistant to a 1 MeV Kr+ ion irradiation at 25 K to a dose of 5 dpa. In this study, a 1.5 MeV Xe+ irradiation was completed for zirconate pyrochlores A2Zr2O7 (A=La, Nd, Sm, Gd). The radiation resistance decreases with an increase of the ionic radius of A-site cation. La2Zr2O7 is the first zirconate pyrochlore to be amorphized by ion beam

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