Relevant bibliographies by topics / DPA-714

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Academic literature on the topic 'DPA-714'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "DPA-714"

1

Lin, Qianqian, Youliang Wang, Wenlong Zhao, and Shaobo Yao. "Visualization of Thromboinflammation by 18F-DPA-714 PET in a Stroke Patient." Clinical Nuclear Medicine 48, no. 10 (2023): e477-e479. http://dx.doi.org/10.1097/rlu.0000000000004803.

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Abstract A 44-year-old man who presented with progressive right limb weakness was diagnosed with ischemic stroke. He was referred for 18F-DPA-714 PET/CT for evaluation of the disease. 18F-DPA-714 PET/CT showed increased uptake of the intracranial thrombus. This DPA-714–avid thrombus highly suggested the involvement of immune cells in the extension of the clot resulting in neurological deterioration. This present case suggested that 18F-DPA-714 PET might be a promising tracer in visualizing thromboinflammation in vivo.
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Boutin, Hervé, Christian Prenant, Renaud Maroy, et al. "[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats." PLoS ONE 8, no. 2 (2013): e56441. https://doi.org/10.1371/journal.pone.0056441.

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<strong>Purpose: </strong>Neuroinflammation is involved in several brain disorders and can be monitored through expression of the&nbsp;translocator protein 18 kDa (TSPO) on activated microglia. In recent years, several new PET radioligands for TSPO have been&nbsp;evaluated in disease models. [18F]DPA-714 is a TSPO radiotracer with great promise; however results vary between different&nbsp;experimental models of neuroinflammation. To further examine the potential of [18F]DPA-714, it was compared directly to&nbsp;[11C]PK11195 in experimental cerebral ischaemia in rats. <strong>Methods:</strong>
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Vicidomini, Caterina, Mariarosaria Panico, Adelaide Greco, et al. "In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET." Nucl Med Biol. 42, no. 3 (2014): 309–16. https://doi.org/10.1016/j.nucmedbio.2014.11.009.

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INTRODUCTION:&nbsp;The translocator protein 18kDa (TSPO), a biochemical marker of neuroinflammation, is highly expressed in the brain activated microglia and it is also expressed by peripheral inflammatory cells and normal peripheral tissues. Thus, development of radioligands for the TSPO may contribute to further understanding the in vivo TSPO function in central and peripheral inflammatory processes and other pathologies. Here, we report the biodistribution, the specific binding and the radiometabolites of [(18)F]DPA-714, a promising fluorinated PET radiotracer, in normal mice using a microP
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Zheng, Jinzi, Alexandra Winkeler, Marie-Anne Peyronneau, Frédéric Dollé, and Raphael Boisgard. "Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation." Molecular Imaging and Biology 18, no. 1 (2015): 127–34. https://doi.org/10.1007/s11307-015-0877-x.

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PURPOSE: Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [18F]DPA-714 for positron emission tomography (PET) imaging of cancer and inflammation. PROCEDURES: [18F]DPA-714 PET imaging was performed in 8 mouse and rat models of breast and brain cancer and 4 mouse and rat models of muscular and bowel inflammation. RESULTS: [18F]DPA-714 showed different uptake levels in healthy organs and malignant tissues of mice and rats. Although high and displaceab
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Zinnhardt, Bastian, Michael Müther, Wolfgang Roll, et al. "TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma." Neuro-Oncology 22, no. 7 (2020): 1030–43. http://dx.doi.org/10.1093/neuonc/noaa023.

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Abstract Background Tumor-associated microglia and macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) are potent immunosuppressors in the glioma tumor microenvironment (TME). Their infiltration is associated with tumor grade, progression, and therapy resistance. Specific tools for image-guided analysis of spatiotemporal changes in the immunosuppressive myeloid tumor compartments are missing. We aimed (i) to evaluate the role of fluorodeoxyglucose (18F)DPA-714* (translocator protein [TSPO]) PET-MRI in the assessment of the immunosuppressive TME in glioma patients, and (ii) to cross
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Golla, Sandeep SV, Ronald Boellaard, Vesa Oikonen, et al. "Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients." Journal of Cerebral Blood Flow & Metabolism 35, no. 5 (2015): 766–72. http://dx.doi.org/10.1038/jcbfm.2014.261.

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Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([18F] DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model for quantification of [18F]DPA-714 binding in healthy subjects and Alzheimer's disease (AD) patients, and to provide a preliminary assessment whether there is a disease-related signal. Ten AD patients and six healthy subjects underwent a dynamic positron emission tomography (PET) study along with arte
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Ory, Dieter, Andrey Postnov, Michel Koole, et al. "Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [(18)F]DPA-714 PET." Eur J Nucl Med Mol Imaging 43, no. 1 (2015): 163–72. https://doi.org/10.1007/s00259-015-3172-9.

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PURPOSE: [(18)F]DPA-714 is a radiotracer with high affinity for TSPO. We have characterized the kinetics of [(18)F]DPA-714 in rat brain and evaluated its ability to quantify TSPO expression with PET using a neuroinflammation model induced by unilateral intracerebral injection of lipopolysaccharide (LPS). METHODS: Dynamic small-animal PET scans with [(18)F]DPA-714 were performed in Wistar rats on a FOCUS-220 system for up to 3&nbsp;h. Both plasma and perfused brain homogenates were analysed using HPLC to quantify radiometabolites. Full kinetic modelling of [(18)F]DPA-714 brain uptake was perfor
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Golla, Sandeep SV, Ronald Boellaard, Vesa Oikonen, et al. "Quantification of [18F]DPA-714 binding in the human brain: initial studies in healthy controls and Alzheimer's disease patients." Journal of Cerebral Blood Flow and Metabolism 35, no. 5 (2015): 766–72. https://doi.org/10.1038/jcbfm.2014.261.

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Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-&alpha;]pyrimidine-3-yl)acetamide ([18F]DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model for quantification of [18F]DPA-714 binding in healthy subjects and Alzheimer&#39;s disease (AD) patients, and to provide a preliminary assessment whether there is a disease-related signal. Ten AD patients and six healthy subjects underwent a dynamic positron emission tomography (PET) study along
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Keller, Thomas, Anna Krzyczmonik, Sarita Forsback, et al. "Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats." Molecular Imaging & Biology 19, no. 5 (2017): 736–45. https://doi.org/10.1007/s11307-016-1040-z.

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PURPOSE: Many neurological conditions result in the overexpression of the translocator protein 18&nbsp;kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are a particularly attractive class of TSPO-specific ligands, prompting the development of several positron emission tomography (PET) radiotracers. This includes F-DPA, a recently reported fluorinated ligand (K <sub>i</sub>&thinsp;=&amp;thinsp;1.7&nbsp;nM), wherein the fluorine atom is directly linked to the phenyl moiety without the presence of an alky
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Werry, Eryn L., Victoria A. King, Melissa L. Barron, Samuel D. Banister, Renee Sokias, and Michael Kassiou. "Derivatives of the pyrazolo[1,5-a]pyrimidine acetamide DPA-713 as translocator protein (TSPO) ligands and pro-apoptotic agents in human glioblastoma." European Journal of Pharmaceutical Sciences 96 (September 19, 2016): 186–92. https://doi.org/10.1016/j.ejps.2016.09.026.

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The 18kDa translocator protein (TSPO) is a target for novel glioblastoma therapies due to its upregulation in this cancer and relatively low levels of expression in the healthy cortex. The pyrazolo[1,5-a]pyrimidine acetamides, exemplified by DPA-713 and DPA-714, are a class of high affinity TSPO ligands with selectivity over the central benzodiazepine receptor. In this study we have explored the potential anti-glioblastoma activity of a library of DPA-713 and DPA-714 analogues, and investigated the effect of amending the alkyl ether chain on TSPO affinity and functional potential. All ligands
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Dissertations / Theses on the topic "DPA-714"

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Awde, Ali Reda. "Evaluation de la protéine translocatrice TSPO comme cible pour l’imagerie moléculaire et la thérapie du glioblastome dans un modèle expérimental chez le rat." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P647.

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Avec 3000 nouveaux cas par an en France, le glioblastome multiforme (GBM) est la tumeur primitive du cerveau la plus fréquente. C’est aussi la plus agressive, l’espérance de vie moyenne des patients au moment du diagnostic ne dépassant guère 15 mois. Depuis l’étude de Stupp et collaborateurs en 2005, l’association radiothérapie – temozolomide est le traitement de référence en première ligne des glioblastomes nouvellement diagnostiqués. La protéine de la translocation (translocator protein, TSPO), connu aussi sous le nom de récepteur périphérique des benzodiazépines ou PBR, joue un rôle dans la
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Nguyen, Duc Loc. "Apport de l’imagerie TEP TSPO dans un modèle d’épilepsie mésio-temporale chez la souris." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS393/document.

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Le modèle induit par injectionunilatérale intrahippocampique d’acide kaïniquechez la souris présente de grandes analogiesavec l’épilepsie mésio-temporale (EMT) chezl’homme caractérisée par la périoded’épileptogénèse et par une sclérosehippocampique (SH) typique.De récents travaux ex vivo ont révélé l’existencede processus neuroinflammatoires au niveau dela SH chez des patients épileptiques et dans desmodèles animaux. La protéine translocatrice de18kDa (TSPO), la plus étudiée actuellement aumoyen de différents traceurs, est considéréecomme une cible de référence pour visualiser etquantifier la
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Bernards, Nicholas. "PET molecular imaging of peripheral and central inflammatory processes targeting the TSPO 18 kDa." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112211/document.

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L’objectif de la thèse: À ce jour, il est admis que la TSPO joue un rôle important dans le processus inflammatoire, et qu’il est possible de suivre sa présence à l’aide d’une variété de radiotraceurs adaptés. Les impacts de l’inflammation touchent un grand nombre de personnes à travers le monde pour diverses raisons ; c’est pourquoi, quoique le [ ¹ ⁸F]DPA-714 est très prometteur, il est nécessaire d’aller plus loin pour explorer ses capacités et ses applications possibles. L’inflammation a une forte incidence sur différentes maladies, par conséquent, à impact social élevé (comme la maladie inf
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Hamelin, Lorraine. "Analyse de la morphologie des sillons corticaux et de l'activation microgliale dans la maladie d'Alzheimer : étude couplée en IRM, TEP-PiB et TEP-DPA Sulcal morphology as a new imaging marker for the diagnosis of early onset Alzheimer’s disease Early and protective microgial activation in Alzheimer's diease: a prospective study using 18F-DPA-714 PET imaging Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer’s disease." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2327&f=13526.

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La maladie d’Alzheimer (MA) est la première cause de démence dégénérative. Elle est ‏définie par l’accumulation anormale des protéines Tau et myloïdes, constituant des plaques‏ amyloïdes. Alors que l’atteinte neuro-pathologique de la MA est stéréotypée chez les malades, son ‏expression clinique et son pronostic sont hétérogènes. Les facteurs modulant l’expression de la ‏maladie sont actuellement peu connus.‏ Dans ce travail, nous avons analysé deux facteurs modulateurs de l’expression de la ‏maladie : l’âge et l’activation microgliale que nous avons étudié au sein d’une population de sujets‏ a
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Coda, Anna Rita Daniela. "In vivo imaging of TSPO in mouse model of neuroinflammation using small-animal PET with [18F]DPA-714." Tesi di dottorato, 2017. http://www.fedoa.unina.it/11450/1/coda_anna%20rita%20daniela_29.pdf.

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Introduction: Neuroinflammation (NI) may play an important role in stroke, neuroinflammatory and neurodegenerative diseases, involving microglia, astrocytes and peripheral immune cells. The translocator protein 18 kDa (TSPO) is an interesting marker of in vivo neuroinflammation because it is highly expressed by activated microglia under pathological conditions. In vivo PET imaging may provide new insight on the dynamic, topography and extent of NI since the earliest stage. Aim: To validate biodistribution and specific binding of [18F]DPA-714, a promising fluorinated radiotracer that targets th
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Conference papers on the topic "DPA-714"

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Roll, W., C. Strippel, B. Zinnhardt, et al. "[18F]DPA-714 PET-MR-Bildgebung in seropositiven und seronegativen limbischen Encephalitiden." In NuklearMedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1683551.

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Backhaus, P., W. Roll, C. Beuker, et al. "Imaging TSPO expression with F-18-DPA-714 PET/MRI in Patients with Suspected PACNS." In NuklearMedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1683516.

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