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1

Lisboa, Johnny. "Etude structurale et fonctionnelle de DprA et de ses partenaires au cours de la transformation génétique naturelle." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114853.

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La transformation génétique naturelle est un mode de transfert horizontal de gènes chez les bactéries, qui contribue au maintien et à l'évolution de leurs génomes. C’est un mécanisme clé pour l’adaptation des bactéries, qui pourrait être responsable de la transmission des résistances aux antibiotiques observée en clinique chez certaines espèces pathogènes (S. pneumoniae, H. pylori,…). La transformation naturelle s’effectue par l’internalisation d’ADN exogène à travers la membrane, puis par sa prise en charge jusqu’à son intégration dans le chromosome bactérien par recombinaison homologue. Le p
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2

Diits, Mimmie. "Design pattern recommender(DPR) : En utvärdering av ett DPR system." Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11556.

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Recommender system blir allt vanligare och att kombinera recommender system med användningen av design patterns kan vara ett steg i rätt riktning för att komma närmre tekniker och program som skulle kunna öka kvaliteten hos programvaran i programvaruutveckling genom att öka utbyggbarheten och underhållbarheten hos programvaran. Syftet med arbetet i den här rapporten är att utvärdera ett design pattern recommender program. Programmet kommer att utvärderas med hjälp av intervjuer av utvecklare och fallstudier hos tre företag. Frågorna i intervjun kommer att bygga på kriterier som används för utv
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3

Nam, Chanhyun. "Beijing and the 1961 PRC-DPRK security treaty." Thesis, Monterey, California. Naval Postgraduate School, 2010. http://hdl.handle.net/10945/5096.

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Approved for public release; distribution is unlimited<br>This thesis addresses the continuation of PRC-North Korean alliance even though significant changes have emerged in international security environment. Numerous studies have focused on the decreased strategic value of North Korea with respect to Chinese national interests, but Pyongyang still serves as stepping stone for China to expand its leverage. China's national objectives of maintaining its leverage in Northeast Asia indicates that Beijing will maintain the 1961 alliance to assure its security interests. By examining the forma
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4

Garbagnati, Chiara <1996&gt. "Implications of the Nuclear Issue in the DPRK." Master's Degree Thesis, Università Ca' Foscari Venezia, 2021. http://hdl.handle.net/10579/19200.

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La questione nucleare rappresenta il principale elemento critico nella storia recente della Repubblica Popolare Democratica di Corea. È noto quanto la problematica occupi centralità nella discussione attuale circa i rischi di instabilità che pone a livello geopolitico, date le due crisi nucleari che hanno riguardato il paese. Nella tesi, viene affrontata l’ideologia, il Juche, e si forniscono cenni storici inerenti la sua creazione. Segue una discussione della questione nucleare, che intende fornire un’analisi del modus operandi della RpdC e di come la questione si è venuta evolvendo a livello
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5

Licata, Nausicaa Valentina. "Identification of new pathways modulating C9orf72-derived DPRs expression." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276572.

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The hexanucleotide repeat expansion GGGGCCn (also known as G4C2n) localizes in the first intron of the C9ORF72 gene and is the most common genetic cause of ALS and FTD (C9ALS/FTD). The pathomechanisms proposed for C9ALS/FTD suggest that from sense (G4C2)n- and anti-sense (C4G2)n-containing transcripts originate two different mechanisms of toxicity: i) by the alteration of RNA processing due to binding and sequestration of RNA-binding proteins, thereby leading to impairment of RNA metabolism; and ii) by their unconventional Repeat-associated non AUG (RAN) translation into five different dipepti
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Licata, Nausicaa Valentina. "Identification of new pathways modulating C9orf72-derived DPRs expression." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/276572.

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The hexanucleotide repeat expansion GGGGCCn (also known as G4C2n) localizes in the first intron of the C9ORF72 gene and is the most common genetic cause of ALS and FTD (C9ALS/FTD). The pathomechanisms proposed for C9ALS/FTD suggest that from sense (G4C2)n- and anti-sense (C4G2)n-containing transcripts originate two different mechanisms of toxicity: i) by the alteration of RNA processing due to binding and sequestration of RNA-binding proteins, thereby leading to impairment of RNA metabolism; and ii) by their unconventional Repeat-associated non AUG (RAN) translation into five different dipepti
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7

Slavík, Roman. "Produkt DPD Intercontinental v podmínkách expresních služeb." Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-16484.

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The submitted diploma thesis deals with the courier, express and parcel market and the product DPD Intercontinental. The courier, express and parcel market is analyzed in terms of today's state of the market as well as trends of the market changes. Product DPD Intercontinental is examined from many points of views, particularly related to competitive situation on the market. As a result is presented SWOT analysis and on its basis is determined goal for the product in question. The goal should be fulfilled by realization of suggested measures.
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8

Richardson, Christopher William. "Childhood Policies and Practices in the DPRK: A Challenge to Korean Unification." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/15000.

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This thesis investigates the childhood policies and practices of the Democratic People’s Republic of Korea (DPRK), exploring the ideological construction of the North Korean child through arts, education, discipline and play, elements of what might be termed a broader collectivisation of childhood. North Korean childhood is perceived not as a protected pre-political phase in individual human growth, but a foundational stage in the construction of revolutionary consciousness, fostering national cohesion, ideological purity, and reverence for Kim Il Sung, Kim Jong Il, and Kim Jong Un. Guided by
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9

Clement, Theo. "China’s economic engagement strategies towards a reforming DPR Korea." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE2051/document.

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Depuis le début des années 2000, la Chine et la RPDC (« Corée du Nord) ont tenté de mettre en œuvre des programmes de coopération économique et d’intégration transfrontalière. Ces programmes de coopération ont été facilité par des politiques réformatrices en Corée du Nord, la famine des années 1990 ayant fait prendre conscience à Pyongyang qu’un certain degré de réforme économique était nécessaire pour reprendre le contrôle et relancer une économie désorganisée et appauvrie. En conséquence, les échanges et les investissements entre la Chine et la RPDC ont connu une hausse spectaculaire. Ceci é
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10

Tanaka, Daisuke, Asahi Hishida, Keitaro Matsuo, et al. "Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese." Nagoya University School of Medicine, 2005. http://hdl.handle.net/2237/5412.

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11

Park, Hee-Eun. "Food Security in the DPRK Since the Great Famine of the Mid-1990s." Thesis, The George Washington University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10159055.

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<p> Since the Great Famine of the mid-1990s, the the Democratic People&rsquo;s Republic of Korea (DPRK) has experienced significant socioeconomic and political changes. Most importantly, the ways in which North Koreans produce, distribute, and consume food, which shed light on food security, has changed in a great deal. Scholars have sought to understand whether and how food security has improved and why the regime stayed in power despite predictions of its likely demise. The paper examines trends among indicators of food security&mdash;food availability and nutritional status in the DPRK&mdas
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12

Ephrussi, Seth I. "Life in the shadow: an examination of the minor foreign relations of the DPRK." Thesis, Monterey, California: Naval Postgraduate School, 2014. http://hdl.handle.net/10945/41372.

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Approved for public release; distribution is unlimited.<br>This thesis explores the diplomatic relations of North Korea, officially known as the Democratic People's Republic of Korea (DPRK), with an emphasis on its minor diplomatic relations. Minor, for purposes of this thesis, refers to those states other than the Big Four Plus One (i.e., China, Japan, South Korea, Russia, and the United States). This thesis covers the evolution of these relations, assesses trends, and predicts the direction in which these relations may be headed. While many refer to North Korea as a hermit kingdom, its diplo
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13

Bolton, Derek. "Identity maintenance & foreign policy decision-making : the quest for ontological security in the DPRK." Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760979.

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This thesis analyzes how the need for ontological security (OS), the ‘security of being’,impacts the foreign policy decision-making of states. Traditional security studies focus primarily on physical threats to the state. By contrast, an OS framework argues individuals feel secure when they are able to maintain communal narrative. This narrative in turn becomes the lens through which policymakers, and thus states, analyze events, while also becoming a potential source of conflict if challenged. Therefore, while physical security is still important, one is better positioned to account for perce
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14

Horta, Agnus Azevedo 1967. "Implementação de simulador de fluidodinâmica em meso-escala com o método DPD." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/265879.

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Orientador: Luiz Otávio Saraiva Ferreira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Mecânica<br>Made available in DSpace on 2018-08-26T05:32:16Z (GMT). No. of bitstreams: 1 Horta_AgnusAzevedo_M.pdf: 4762311 bytes, checksum: 1bcc55cdb06dfc294f352fc1ac27c0ad (MD5) Previous issue date: 2014<br>Resumo: Este trabalho tem como objetivo principal a implementação do motor de simulação de um framework de simulação com partículas, o motor de simulação utilizará o método DPD (Dissipative Particle Dynamics), baseando-se no paradigma de programação orientada a
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15

Delhorme, Jean-Baptiste. "Etude des mécanismes de chimiorésistance dans les cancers digestifs : impact de CDX2 et des transporteurs ABC." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ119.

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La chimiorésistance est un enjeu majeur dans la prise en charge des patients atteints de cancers digestifs et peut se manifester par l’efflux de molécules cytotoxiques via la surexpression des transporteurs ABC. Le facteur de transcription CDX2 est un régulateur important de l’identité intestinale et agit comme gène suppresseur de tumeur dans le côlon. Il pourrait être impliqué dans des phénomènes de chimiorésistance des cancers colorectaux (CCR) car le transporteur MDR1/ABCB1 correspond à un de ses gènes cibles. Nous avons confirmé le rôle de CDX2 dans la chimiorésistance des CCR. Nous avons
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16

Mildenberg, Mary E. "The North Korea Problem: US policy toward North Korea from 2001-2013." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/cmc_theses/748.

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Few countries have presented a policy problem for the United States with the consistency and longevity that North Korea has. The opacity of the regime that runs the Democratic People’s Republic of Korea has served as a barrier to deciphering the policy perspective that Kim Jong-un, and his father before him, have pursued. This thesis analyzes the policy decisions of the US towards North Korea in an attempt to decipher which policies were pursued and what there effects have been. Modern US policy in regards to North Korea started with the signing of the Agreed Framework in 1994. US policy was l
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17

Borsuk, Sibele. "Construção de marcador auxotrófico em Mycobacterium bovis BCG, de uma cepa knockout para DPPD e estudo proteômico da tuberculina." Universidade Federal de Pelotas, 2008. http://repositorio.ufpel.edu.br/handle/ri/1257.

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Made available in DSpace on 2014-08-20T13:32:52Z (GMT). No. of bitstreams: 1 tese_sibele_borsuk.pdf: 16306468 bytes, checksum: 4743a54f442368d81ff802d8290c7cfc (MD5) Previous issue date: 2008-02-28<br>Mycobacterium bovis BCG has the potential to be an effective live vector for multivalent vaccines. However, there are two problems regarding the utilization of recombinant BCG as vaccine. The first one is that most mycobacterial cloning vectors rely on antibiotic resistance gene as selectable marker, which is used for genetic transformation. The second one is the limited use of BCG in an
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18

Hussain, Hanaa Mohammad. "Dynamically and partially reconfigurable hardware architectures for high performance microarray bioinformatics data analysis." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7645.

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The field of Bioinformatics and Computational Biology (BCB) is a multidisciplinary field that has emerged due to the computational demands of current state-of-the-art biotechnology. BCB deals with the storage, organization, retrieval, and analysis of biological datasets, which have grown in size and complexity in recent years especially after the completion of the human genome project. The advent of Microarray technology in the 1990s has resulted in the new concept of high throughput experiment, which is a biotechnology that measures the gene expression profiles of thousands of genes simultane
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Nandi, Om Prakash. "Behavioral Modeling of Power Amplifier with Memory Effect and Linearization Using Digital Pre Distortion." Thesis, Högskolan i Gävle, Elektronik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22830.

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This thesis work studied the behavioral modeling, estimation of parameters, model performance and linearization of power amplifier (PA) using Digital Pre Distortion (DPD) technique. PAs are one of the fundamental block in communication systems and also one of the main sources of nonlinearities in the system, as these devices are frequently subjected to signals characterized by considerable bandwidths and non-constant envelopes due to use of modern modulation technique. Moreover, PAs have high efficiency level at its nonlinear region. So, to operate the PA at its high efficiency region, lineari
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Cohn, Brian E. "Development of a Dynamic Event Tree Branching Methodology to Integrate Safety and Physical Security Analyses." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1607428620063068.

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Celma, Louisa. "Mécanismes moléculaires de la transformation génétique naturelle chez la bactérie pathogène Helicobacter pylori." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS089.

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Helicobacter pylori est une bactérie à Gram-négatif qui colonise la muqueuse de l’estomac humain. Elle se distingue des autres bactéries par un nombre de gènes très limité et de nombreuses particularités physiologiques et biochimiques. Elle provoque des infections associées à différentes maladies gastro-duodénales (ulcères et cancers). Depuis quelques années, une recrudescence de multi-résistances aux antibiotiques est observée. La transformation naturelle est l’un des processus clés qui les propage. Il s’agit d’un mécanisme de transfert horizontal de gènes qui permet aux bactéries de s’adapte
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Sá, Joana Savva Bordalo e. "Epigenetic and genetic alterations of DPYD are not predictive of severe toxicity to 5-Fluorouracil-based chemotherapy in gastrointestinal cancer." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/45073.

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Sá, Joana Savva Bordalo e. "Epigenetic and genetic alterations of DPYD are not predictive of severe toxicity to 5-Fluorouracil-based chemotherapy in gastrointestinal cancer." Dissertação, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/45073.

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24

Nunna, Keerthana. "Production Deduction, What’s Your Function?: Analyzing the Effectiveness of the Domestic Production Activities Deduction." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/cmc_theses/1137.

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The domestic production activities deduction (DPAD) was created to incentivize U.S. firms to produce within the U.S. and thereby increase domestic investing. I test whether the DPAD is a large enough incentive for firms to invest in the U.S. I used a simulation, and I found that without the DPAD incentive the firms never chose to produce within the U.S. With the DPAD incentive, only firms with relatively low costs of labor will produce domestically. These firms are rare and will not have a large impact on domestic investment and these firms increasing their production in the U.S. will not have
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Rodgers, Thomas Lawrence. "Multiple-scale approach to understanding formulated product production." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/multiplescale-approach-to-understanding-formulated-product-production(a0de5c77-1bb7-4d7b-af3a-8ccb44a80f42).html.

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Consumer- and pharmaceutical-based products are a major component of the chemical industry. In the personal care industry, formulations often consist of a mixture of surfactants and fatty alcohols. The addition of surfactants aids the stability of the formulation. The formulated product microstructure depends upon the preparation conditions as well as the ingredients. Controlling which microstructures form during the production of a formulated product is important as different microstructures can have wildly different physical properties, making some far more favourable than others. This thesi
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Slimane, Manel. "Développement d’une approche multi-échelle pour l'étude de la solubilité des flavonoïdes et leur assemblage avec les polymères." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0347.

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Depuis quelques décennies, les flavonoïdes sont de plus en plus utilisés dans différents domaines d’applications alimentaires et non alimentaires. Cet engouement est dû principalement à leurs activités antioxydantes. Cependant, la solubilisation, la dispersion et la stabilisation de ces molécules sont variables et constituent un frein à leur utilisation. L’objectif de ce travail est de pallier cet inconvénient en visant à comprendre les interactions entre ces composés et leur milieu en absence et en présence de polymères, par une double approche expérimentale et par modélisation et mésomodélis
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Wessinger, Veronika Elisabeth [Verfasser], Alfons [Akademischer Betreuer] [Gutachter] Meindl, and Marion B. [Gutachter] Kiechle. "Analyse von DPYD-Polymorphismen zur Abklärung 5-FU-bedingter Nebenwirkungen / Veronika Elisabeth Wessinger ; Gutachter: Marion B. Kiechle, Alfons Meindl ; Betreuer: Alfons Meindl." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1139843788/34.

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Yao, Miao. "Exploiting Spatial Degrees-of-Freedom for Energy-Efficient Next Generation Cellular Systems." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/77402.

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This research addresses green communication issues, including energy efficiency, peak-to-average power ratio (PAPR) reduction and power amplifier (PA) linearization. Green communication is expected to be a primary goal in next generation cellular systems because it promises to reduce operating costs. The first key issue is energy efficiency of distributed antenna systems (DASs). The power consumption of high power amplifiers (HPAs) used in wireless communication systems is determined by the transmit power and drain efficiency. For unequal power allocation of orthogonal frequency division mu
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Bell, Tyler J. "Development and Implementation of Dispersion Phase Diagrams (DPDs) for Four Different Hydrophobically Modified Ethoxylated Urethane (HEUR) Based Acrylic Paint Systems." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1210.

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Latex polymers serve as binders in a wide range of architectural paints and coatings. A latex is an aqueous colloidal dispersion of polymer particles that when dried above the polymer’s film formation temperature coalesces into a dry polymer film (Dragnevski, Routh, Murray, & Donald, 2010). The other main components of paint include associative thickeners, surfactants, pigments and fillers with the thickener being the primary area of focus for this study. The relatively simple system of latex, associative thickener and surfactant has been studied extensively. These studies have shown the mecha
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Galarza, Andrés Fernando Andrade. "Avaliação genotípica e fenotípica da enzima diidropirimidina desidrogenase (DPD) e risco de toxicidade com o uso de fluoropirimidinas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/143351.

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Base teórica: As fluoropirimidinas possuem significativa variabilidade na resposta terapêutica e na ocorrência de toxicidade, o que tem sido relacionado à deficiência na depuração metabólica mediada pela enzima diidropirimidina desidrogenase (DPD). Mutações nos genes codificadores da enzima, bem como fatores ambientais podem levar à baixa ou nula expressão enzimática, provocando efeitos adversos graves devido ao acúmulo destes fármacos. Até o presente, nenhum teste reconhecidamente valido para a identificação de indivíduos em risco de toxicidade severa está estabelecido na prática oncológica.
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Yang, Chenguang. "Déficit en dihydropyrimidine déshydrogénase (DPD) et fluoropyrimidines : impact sur la pharmacocinétique et toxicité du 5-FU et xéloda." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20704.

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Bien que synthétisé il y a plus d’un demi-siècle, le 5-FU reste la fluoropyrimidine la plus largement utilisée dans le traitement de diverses tumeurs solides de l’adulte. On sait également que sa toxicité impacte gravement non seulement sur la qualité de vie des patients (douleur, allongement de la durée d’hospitalisation), mais qu’elle perturbe également la poursuite du schéma thérapeutique optimal. Un facteur majeur prédisposant les patients au développement de toxicités sévères sous 5-FU est la déficience en DPD et le ratio plasmatique U/UH2 physiologique semble être le meilleur outil dispo
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Picoco, Claudia. "Integrated Framework for Representing Recoveries Using the Dynamic Event Tree Approach." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu155550242815033.

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Antonsson, Henrik. "Lyfthjälpmedel : för hantering av tyngder, vid kalibrering av momentgivare och digitala momentnycklar." Thesis, University West, Department of Technology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-751.

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Yang, Jun. "A Smoothed Dissipative Particle Dynamics Methodology For Wall-Bounded Domains." Digital WPI, 2013. https://digitalcommons.wpi.edu/etd-dissertations/225.

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This work presents the mathematical and computational aspects of a smooth dissipative particle dynamics with dynamic virtual particle allocation method (SDPD-DV) for modeling and simulation of mesoscopic fluids in wall-bounded domains. The SDPD-DV method is realized with fluid particles, boundary particles and dynamically allocated virtual particles near solid boundaries. The physical domain in SDPD-DV contains external and internal solid boundaries, periodic inlets and outlets, and the fluid region. The solid boundaries of the domain are represented with boundary particles which have an a
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Thorndike, David Andrew. "A Multicore Computing Platform for Benchmarking Dynamic Partial Reconfiguration Based Designs." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1338933284.

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Ratnasamy, Varun. "Automatic Linearization and Feedforward Cancellation of Modulated Harmonics for Broadband Power Amplifiers." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1448974356.

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Jarray, Ahmed. "Mesoscopic modeling, experimental and thermodynamic approach for the prediction of agglomerates structures in granulation processes." Phd thesis, Toulouse, INPT, 2015. http://oatao.univ-toulouse.fr/15112/1/jarray.pdf.

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Wet granulation process requires the addition of a coating agent or binder, typically composed of surfactants, water, plasticizers and fillers. In dry granulation however, the coating agent is added to the system in the form of fine solid particles. Our goals are to investigate the particles behaviour and agglomeration mechanism in dry and aqueous systems at the micro and meso scales, and also, to develop predictive methodologies and theoretical tools of investigation allowing to choose the adequate binder and to formulate the right coating solution. In this study we chose materials widely use
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Scheidhauer, R. "A historiography of cultural heritage interpretation and policy in Kaesŏng, DPR Korea and their possible impact on inter-Korean rapprochement." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1336212/.

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Korea’s dividing ideologies of the past century, and the dominant efforts to legitimise the respective political agendas of the two States, have had an impact on the interpretation of, and the choice of focus within, cultural heritage and history. Cultural heritage policies are part of this particular historical narrative, reflected in heritage interpretations and activities. Whereas the socio-political studies of unification focus on a territorial unification, an approach coming from cultural heritage has the potential advantage of being able to focus on congruence through common roots, views
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Ovšonka, Pavol. "NUCLEAR WEAPONS AS A TOOL OF NORTH KOREAN FOREING POLICY." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-113618.

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In 1990's, the North Korean leaders opened the military nuclear program in order to avoid the collapsing trend which affected many totalitarian regimes at that time. Thanks to the specific geographical position, Inter-Korean dispute became a very important issue of foreign policy of many great powers such as United States of America, People's Republic of China, Japan, or Russian Federation. This nuclear program is generally considered as a tool of threatening in order to maintain the regime and secure the food and energy assistance. In this thesis, the North Korean threatening policy is applie
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Mokkapati, Srinivas Praveen. "Simulation of particle agglomeration using dissipative particle dynamics." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1149.

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41

Muñoz, García Carmen. "Polimorfismos en el gen dihidropirimidina dehidrogenasa (DPYD) y citidina deaminasa (CDA) como factores pronóstico en pacientes con cáncer gástrico resecados tratados con quimioterapia adyuvante con fluoropirimidinas." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/691.

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ESTUDIO: Se sabe que DPYD interviene en procesos catabólicos ó de degradación del 5-fluorouracilo, así como el enzima CDA participa en procesos anabólicos, al proveer de sustrato a la timidilato sintetasa para la síntesis de DNA, y por analogía, en la síntesis de RNA. Por lo tanto, la incorporación de la molécula de 5-FU por semejanza a la molécula de uracilo en procesos anabólicos significa el freno en la síntesis de DNA y de RNA tumoral, al "engañar" el fármaco a los enzimas de estas vías.<br/><br/>OBJETIVOS: 1. Analizar polimorfismos en los genes dihidropirimidina dehidrogenasa (DPYD) y cit
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Lee, Ergene. "The 1993 North Korean Nuclear Crisis: A Foreign Policy Analysis." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/33477.

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In this paper I apply the Rational Actor model to the 1993-1994 North Korean Nuclear Crisis. I begin with two hypotheses: 1) North Korea attempted nuclear armament because of its perception of threat from South Korea and the United States; 2) North Korea attempted nuclear armament because it wanted to use its nuclear program as leverage to obtain economic assistance from the United States. I conduct a diplomatic historical analysis based on the Rational Actor model to determine which was North Koreaâ s primary objective, and conclude that the primary objective of North Korea was obtaining eco
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Varpahovskis, Eriks. "SOCIALIST LEGACY: WEST GERMAN PERCEPTION OF EAST GERMANS AND SOUTH KOREAN PERCEPTION OF NORTH KOREANS." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23894.

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Opposition of socialist East and capitalist West in XX century led to division of nations andcreation of new states. Due to historical process Korea and Germany were divided intoDemocratic People’s Republic of Korea and Republic of Korea, and German DemocraticRepublic and Federal Republic of Germany, respectively. Development of states requiredconstruction of new ethnic identities/ethnicities. In this research through the prism of Cornell andHartmann’s constructivist approach and stereotype theory secondary and primary data isanalyzed.. On the basis of analysis of secondary data this research
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Mengozzi, Mattia. "Direct Learning Power Amplifier Digital Predistortion using Multi-Objective Optimization." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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All’interno di una stazione radio base l’amplificatore di potenza a radiofrequenza (RF PA) è di gran lunga l’elemento più importante dal punto di vista energetico, dato che il suo compito è quello di fornire al segnale la potenza necessaria per essere trasmesso. Di conseguenza sono state sviluppate numerose tecniche per aumentare l’efficienza e la linearità dei PA. Ad esempio, le architetture di Envelope Tracking (ET) migliorano l’efficienza complessiva del sistema modulando la tensione di alimentazione in banda base (LF), mentre la digital predistortion (DPD) ne incrementa la linearità distor
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Trinh, Jessica. "ADS och Matlab för optimering av pre-distortion av effektförstärkare." Thesis, Linköpings universitet, Institutionen för systemteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119222.

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This master’s thesis deals with integrating simulations using Agilents Electronic Design Automation tool ADS with customized Matlab scripts, for solving complex analog and digital radio architectures. In particular, it addresses predistortion, realized in the digital domain, of power amplifiers, modeled in the analog domain. The former is implemented in Matlab while the latter is implemented in ADS. Two versions of integrating the two systems have been tested: 1) Iterative approach on sample basis and 2) Scheduled batch solution by matrix inversion. The concept has been tested on two different
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Palato, Samuel. "La simulation mésoscopique par dynamique dissipative." Mémoire, Université de Sherbrooke, 2013. http://savoirs.usherbrooke.ca/handle/11143/66.

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La simulation des matériaux demande une compréhension de leur comportement à de nombreuses échelles de temps et d’espace. Ces différentes échelles requièrent des méthodes de simulations différentes, qui se basent sur des approximations différentes et donnent accès à différentes propriétés. La simulation multiéchelle est une approche qui regroupe l’utilisation de ces différentes méthodes, ainsi que des relations qui les unissent. Des développements plus récents ont permis la mise au point de méthodes mésoscopiques, comblant le trou entre les simulations atomistiques (< 10 nm) et les milieux
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Cohn, Brian E. "Reduced Order Modeling of Dynamic Systems for Decreasing Computational Burden in Uncertainty Quantification." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531425355869627.

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Merckel, Fabien. "Détection et évaluation "in chimico" des allergènes de contact : intérêt des microémulsions pour la mesure de la réactivité peptidique et l'activation enzymatique des pro-haptènes." Strasbourg, 2011. http://www.theses.fr/2011STRA6255.

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Actuellement, la détection des sensibilisants cutanés est basée sur l’utilisation d’animaux. Cependant, la pression sociale pour l’abandon des tests « in vivo » est de plus en plus forte. Partant du postulat que le potentiel de sensibilisation d’une molécule peut être corrélé à sa réactivité chimique envers les protéines, le Direct Peptide Reactivity Assay (DPRA), un test « in chemico » basé sur la réactivité peptidique, a été développé. Néanmoins, à l’heure actuelle, le DPRA présente plusieurs limitations. Il est peu compatible avec des molécules très lipophiles à cause de problèmes de solubi
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Sensiate, Lucimara Aparecida. "Análise comparativa da expressão dos genes Dapper (Dpr) durante a ontogênese dos membros de camundongo (Mus musculus C57BL/6) e galinha (Gallus gallus)." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317675.

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Orientador: Lúcia Elvira Alvares<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-18T00:32:50Z (GMT). No. of bitstreams: 1 Sensiate_LucimaraAparecida_M.pdf: 8827752 bytes, checksum: 66afd653eb6cf0a2ff14cc79c158cfc1 (MD5) Previous issue date: 2011<br>Resumo: Dentre as moléculas envolvidas na sinalização molecular durante o desenvolvimento, têm papel de destaque aquelas envolvidas nas vias de sinalização Wnt e TGF-ß. Trabalhos demonstram que as proteínas Dapper (Dpr) são capazes de modular tais vias de sinalização. A fa
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Kim, Ji Woo. "A GENERALIZED ARCHITECTURE FOR THE FREQUENCY-SELECTIVE DIGITAL PREDISTORTION LINEARIZATION TECHNIQUE." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1339690468.

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