Journal articles on the topic 'Dr JHL'

Research about lactation and breastfeeding has exploded since the Journal of Human Lactation ( JHL) began publishing in 1985. To discuss the 3-decade-long role of the Journal in promoting, supporting, and disseminating lactation research, editors convened a multidisciplinary group of lactation researchers and providers which comprised three senior researchers and one clinical practitioner, all of whom have a long history of lactation advocacy. Their discussion took place on July 1, 2019. Dr Aimee Eden is a medical anthropologist who leads the qualitative research efforts in a small research department. Her dissertation research focused on the maternal and child healthcare workforce, and the professionalization of breastfeeding support. She served on the Board of Directors of the International Board of Lactation Examiners (2010–2016) and currently serves on the board of the Monetary Investment for Lactation Consultant Certification. Dr Karleen Gribble has been conducting research for 15 years about infant and young child feeding in emergencies, long-term breastfeeding, milk sharing, early childhood trauma, adoption, and fostering. She is an Australian Breastfeeding Association community educator and breastfeeding counselor and a member of the Infant and Young Child Feeding in Emergencies Core Group. Elien Rouw is a practicing physician in Germany specialized in healthy infant care, with a long-standing specialization in breastfeeding medicine. She serves on the Board of Directors of the Academy of Breastfeeding Medicine, is a member of the German National Breastfeeding Committee and their delegate to the World Alliance for Breastfeeding Action. Dr Jackie Wolf is an historian of medicine, whose research focuses on the history of childbirth and breastfeeding practices in the United States and how those practices have shaped women’s and children’s health, as well as public health, over time. Her latest book, published by Johns Hopkins University Press and funded by a 3 year grant from the National Institutes of Health, is Cesarean Section: An American History of Risk, Technology, and Consequence. Dr Sara Gill moderated the discussion. She was a member of the Board of Directors of the International Lactation Consultant Association for 5 years, and has been an Associate Editor of the Journal of Human Lactation for the past 4 years. Her research has focused on breastfeeding among vulnerable populations. (Participants’ comments are noted as AE = Aimee Eden; SG = Sara Gill; KG = Karleen Gribble; ER = Elien Rouw; JW = Jacqueline Wolf).

Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of diabetes, and the most leading cause of visual loss around the world. The lack of effective and approved treatment in DR is a major challenge for diabetic patients. Nowadays, natural compounds have got attention of the researchers for management of DR. Many evidences suggest that puerarin as a natural polyphenol exerts advantageous effects against DR. In the present review, we summarized the protective effects of puerarin against DR, and discussed the underlying mechanisms of these effects. Puerarin attenuates retinal neovascularization and neurodegeneration in diabetes mellitus, and the underlying mechanisms are related to antioxidant, anti-inflammatory, and antiapoptotic properties of the compound. In conclusion, puerarin might be a potential adjuvant agent for the prevention and treatment of DR. However, comprehensive studies are necessary to show its effectiveness and safety, particularly in human.

The Canadian Society of Clinician Investigators (CSCI) and Clinical Investigator Trainee Association of Canada/Association des cliniciens-chercheurs en formation du Canada (CITAC/ACCFC) annual general meeting (AGM) was held in Toronto during November 21-24, 2015 for the first time in conjunction with the University of Toronto Clinician-Investigator Program Research Day. The overall theme for this year’s meeting was the role of mentorship in career development, with presentations from Dr. Chaim Bell (University of Toronto), Dr. Shurjeel Choudhri (Bayer Healthcare), Dr. Ken Croitoru (University of Toronto), Dr. Astrid Guttman (University of Toronto), Dr. Prabhat Jha (University of Toronto) and Dr. Sheila Singh (McMaster University). The keynote speakers of the 2014 AGM included Dr. Qutayba Hamid, who was presented with the Distinguished Scientist Award, Dr. Ravi Retnakaran, who was presented with the Joe Doupe Award, and Dr. Lorne Babiuk, who was the CSCI-RCPSC Henry Friesen Award winner. The highlight of the conference was, once again, the outstanding scientific presentations from the numerous clinician investigator (CI) trainees from across the country who presented at the Young Investigators’ Forum. Their research topics spanned the diverse fields of science and medicine, ranging from basic science to cutting-edge translational research, and their work has been summarized in this review. Over 120 abstracts were presented at this year’s meeting. This work was presented during two poster sessions, with the six most outstanding submitted abstracts presented in the form of oral presentations during the President’s Forum.

An accomplished academic, collector, and long-time Red Cross volunteer, Professor Dr Rainer Schlösser is head of the Red Cross Museum of the Red Cross Chapter Fläming-Spreewald in Luckenwalde. He has directed the museum since 2000. Since 2006, he has also served as official spokesperson of the Association of the Red Cross Museums in Germany, a group connecting thirteen Red Cross museums across Germany. I met Rainer Schlösser in his office at the Red Cross Museum in Luckenwalde. After an extended and insightful tour through the museum we sat down to discuss his ideas and his work at the museum.1

Abstract According to mineralogical literature, some of the finest opalized wood in the world was discovered in Idaho c.1895, originating in a unique deposit along Clover Creek in Lincoln County (now Gooding County). The American mineral dealer Dr A. E. Foote acquired and processed the bulk of the discovery into specimens that were advertised between 1896 and 1904. Over a period of four years, we have identified sixteen natural history museums in Europe, North America, and Australia in possession of Clover Creek opalized oak today. Many museum acquisitions and the fossil’s taxonomic affinity, Quercinium pliocaenicum, resulted from collective networking between mineral dealers, private collectors and scientists – evidence of a common interest among a diversity of people – contributing the best specimens for museums of natural history.

Prenatal testing has been moving towards non-invasive methods to determine fetal risk for genetic disorders. Numerous studies have focused the attention on common trisomies; although the detection rate (DR) for trisomy 21 is high (over 95%), the accuracy regarding the DR for trisomies 13 and 18 has come under scrutiny. The testing has been applied to sex chromosome aneuploidies, but many studies have shown that it is not as effective as it is for common trisomies. Although non-invasive prenatal test (NIPT) has become a standard screening procedure for all pregnant women, invasive sampling procedures remain important in confirming NIPT-positive findings. In the present study, we report discordant results of Turner syndrome (TS) mosaicism between NIPT and karyotyping. A 35-year-old pregnant woman underwent NIPT, and a probable risk for Xp deletion was indicated. Subsequently, amniocentesis was performed. The karyotype was identified as mos 45,X [28]/46,X,i(X)(q1.0)[5]. In the second case, a 33-year-old woman underwent amniocentesis after a positive NIPT that indicated a probable risk for monosomy X. The result was mos 45,X [8]/46,XY[8]. Since NIPT is a screening test, the possibility of false-positive or false-negative results should always be considered. We underline the importance of pre/post detailed counseling. Furthermore, women with abnormal NIPT results should undergo immediate amniocentesis that remains the only tool for a correct diagnosis of sex chromosome aneuploidies.

Pengelolaan kualitas udara dan pengendalian pencemaran udara harus dilakukan untuk menjaga kelestarian dan keberlangsungan kehidupan. Pengelolaan dan pengendalian pencemaran udara dapat dilaksanakan dengan melakukan pemantauan kualitas udara. Hasil dari pemantauan kualitas udara ambien selanjutnya digunakan untuk perhitungan IKU. Indeks Kualitas Udara/IKU merupakan salah satu instrumen yang dapat digunakan untuk melakukan penilaian kualitas udara secara sederhana dengan menggunakan beberapa parameter terpilih. Indeks Standar Pencemar Udara/ISPU, Parameter yang digunakan untuk menentukan ISPU yaitu Sulfur Dioksida (SO2), Nitrogen Dioksida (NO2), Oksidan (O3), Total Partikel (TSP), Karbon Monoksida (CO), Amoniak (NH3), Hidrogen Sulfida (H2S), Weather Station (Suhu Udara, Tekanan Udara, Kelembaban Udara), Arah dan Kecepatan Angin, GPS (Koordinat Lokasi), Tingkat Kebisingan, dan PM10. Sedangkan untuk perhitungan Indeks Kualitas Udara menggunakan 2 parameter utama yaitu Nitrogen Oksida (NOx) dan Sulfur Oksida (SOx). Pengambilan sampel udara di Kota Tegal menggunakan alat High Volume Air Sampler (HVAS) dengan lama pengambilan selama 24 jam. Lokasi yang digunakan untuk pengambilan contoh kualitas udara ambien terletak di Jl. Dr. Cipto Mangunkusumo untuk pemantauan transportasi. Sedangkan untuk pemantauan kualitas udara dengan metode passive sampler memerlukan waktu selama 14 hari. Lokasi yang dipilih mewakili transportasi, kawasan permukiman, kawasan industri, kawasan perkantoran dan kawasan perdagangan. Pengambilan sampel kualitas udara ambien selama 24 jam digunakan untuk menghitung Nilai Indeks Standar Pencemar Udara (ISPU). Nilai ISPU pada lokasi pemantauan di Jl. Dr. Cipto Mangunkusumo (Terminal Kota Tegal) masing masing yaitu : SO2 sebesar 21,25, CO sebesar 10, NO2 sebesar 48, O3 sebesar 22,92 dan PM10 sebesar 40. Seluruh parameter termasuk dalam rentang 0 – 50 dengan kategori baik.

In JHS cx (1990) 174-7 Dr John Chadwick expresses scepticism about certain lines of argument followed in my article ‘The Rise of the Greek Epic’ (JHS cviii [1988\ 151-72). He will not expect me to be heartened by his remarks. But I am. If this (I reflect) is the worst that the linguistic establishment can throw at me, there cannot be too much wrong with my approach.His paper consists largely of a rehearsal of elementary facts and principles familiar to me and to everyone in the field. We differ, evidently, in our assessments of the bearing of these facts and principles on my reconstruction of the main phases of the epic tradition. I will try to explain succinctly why his representations leave me so unabashed.

The epithelial barrier of the upper respiratory tract plays a crucial role in host defense. In this study, to elucidate whether there is antigen monitoring by dendritic cells (DCs) beyond the epithelial tight-junction barrier in allergic rhinitis, we investigated the expression and function of tight junctions and characterized DCs in the epithelium of nasal mucosa from patients with allergic rhinitis. In reverse transcription-polymerase chain reaction, mRNAs of tight-junction proteins occludin, JAM-1, ZO-1, and claudin-1, −4, −7, −8, −12, −13, and −14 were detected in the nasal mucosa. Occludin, JAM-1, and ZO-1 were colocalized in the uppermost layer in the pseudostratified epithelium of the nasal mucosa, whereas claudin-1, −4, and −7 were found throughout the epithelium. In freeze-fracture replicas of the nasal mucosa, continuous tight-junction strands formed well-developed networks. Epithelial barrier function measured by a dye tracer was well maintained in occludin-positive tight junctions in the epithelium of the nasal mucosa. HLA-DR- and CD11c-positive DCs expressed claudin-1 and penetrated beyond occludin in the epithelium of the nasal mucosa with, but not without, allergic rhinitis. These results indicate that DCs may easily access antigens beyond epithelial tight junctions in the human nasal mucosa of allergic rhinitis.

The new genus Douglasdeweya C. Yen, J.L. Yang & B.R. Baum is based on results from cytogenetical and morphological findings — PPStSt genome — and is segregated from the genus Pseudoroegneria — StSt and StStStSt genome. Several characters, such as the erect spike with very finely spinulose pubescence along the two main angles of the rachis, and glumes and lemmas with a very strong midrib forming a keel-like structure distinguish Douglasdeweya from Pseudoroegneria, which has a rather lax spike, a rachis that is glabrous along the two main angles, and glumes and lemmas without a keel-like structure. The genus is named in memory of Dr. Douglas R. Dewey, an outstanding scientist who worked on the biosystematics of the perennial Triticeae. Two species are described, one of which is new, Douglasdeweya wangyii C. Yen, J.L. Yang & B. R. Baum and the other a new combination Douglasdeweya deweyi (K.B. Jensen, S.L. Hatch, & J.K. Wipff) C. Yen, J.L. Yang, & B.R. Baum. A key to the two species is provided, together with details on their taxonomy, nomenclature, distribution, and cytology.Key words: PPStSt genome, narrow endemic.

The quality of working relationships among medical team members is influenced by communication, which has a significant impact on patient safety. Our study took place at the Dr. Nicolae Robanescu National Neurorehabilitation Center for Children, Bucharest, between October and December 2019 and included 44 participants that were grouped into three categories: physicians, physical therapists, and nurses (32 women and 12 men), aged between 23 and 53, all of whom were employed in the same unit. A total of 5 questions were used to select data on communication difficulties. The chi-square test used for statistical analysis revealed no significant differences between the professional categories participating in the research (p>0.05). We suggest increasing the group size in a future study to increase the statistical significance.

Reproducible visualization of neurons and glia in human brain is essential for quantitative studies of the cellular changes in neurological disease. However, immunohistochemistry in human brain specimens is often compromised because of prolonged fixation. To select cell lineage–specific antibodies for quantitative studies of neurons and the major types of glia, we used 29 different antibodies, different epitope retrieval methods, and different detection systems to stain tissue arrays of formalin-fixed human brain. The screening pointed at CD45/leukocyte common antigen (LCA), CD68(KP1), 2′, 3′ cyclic nucleotide phosphatase (CNPase), glial fibrillary acidic protein (GFAP), HLA-DR, Ki67, neuronal nuclei (NeuN), p25α-antigen, and S100β as candidates for future cell counting purposes, because these markers visualized specific neuronal and glial cell bodies. However, significant negative correlation between staining result and formalin fixation was observed by blinded scoring of staining for CD45/LCA, CNPase, GFAP, and NeuN in brain specimens fixed by immersion and stored up to 10 years in 4% formalin solution at room temperature, independent of donor sex and postmortem interval. In contrast, improved preservation of NeuN and CNPase staining, and full preservation of GFAP and CD45/LCA staining in tissue fixed by perfusion and stored for up to 3 years in 0.1% paraformaldehyde solution at 4C, indicated that immunohistochemistry can be performed in well-preserved biobank material.

The mangrove zoning and landscape express the correlation between mangrove vegetation (density, biodiversity and species distribution) with environment factors like as water inundation, seatide, and soil properties. The research was conducted in Segara Anakan Lagoon to analysis community structure and mangrove landscape based on species distribution, biodiversity, environment factors, and mangrove zoning. The results showed that (a) Segara Anakan Lagoon had 4 mangrove zone's were dominated by Sonneratia alba, Rhizophora mucronata, Avicennia marina, Rhizophora apiculata, Rhizophora styllosa, and Nypa frutican; (b) the structure of ecosystem was showed by trend of mangrove ecosystem with equation y = 35.34x2 923.85x + 12817 with x = time (year) and y = mangrove area (ha), mangrove density between 1333367 ind ha-1 (West Segara Anakan) and 899–567 ind ha-1 (East Segara Anakan), dominated species were Nypa frutican, Rhizophora stylosa, Rhizophora apiculata, and Aegiceras corniculatum and mangrove biodiversity between 2,572,65 (moderate); (c) structure of environment factor showed single and semi double-type tides, water debit between 0.360.73 m s-1; water depth between 0.20–23.7 m and water inundation between 480cm; soil texture was clay and loam, soil nitrate of 1.5 mg 100 g-1, soil phosphate of 1.5 mg 100 g-1, C organic of 1.31%, soil pH of 6–7, and soil salinity of 6.5–10 ppt.

ABSTRAKSI: Tujuan penelitian ini untuk mengetahui kesulitan belajar Matematika dan perbedaan peningkatan kemampuan berpikir logis siswa, yang diberi perlakuan pembelajaran LIT (Local Instruction Theory) dengan pendekatan PMR (Pendidikan Matematika Realistik) dengan siswa yang hanya diberi pendekatan PMR saja. Metode penelitian berupa “design research”, dengan subjek penelitian berjumlah 184 siswa SMP (Sekolah Menengah Pertama), yang berasal dari peringkat sekolah yang berbeda. Hasil penelitian menunjukan bahwa kesulitan belajar yang dialami siswa SMP adalah karena sulit dalam memahami variabel, koefisien, dan konstanta; sulit membaca maksud soal, sulit menyusun strategi dalam menyelesaikan soal; sulit dalam proses perhitungan; dan masih salah dalam penulisan persamaan. Peningkatan kemampuan berpikir logis siswa yang pembelajarannya menggunakan LIT dalam PMR ternyata lebih tinggi daripada siswa yang pembelajarannya menggunakan PMR saja. Perlu kajian lanjutan untuk melihat pengaruh penggunaan LIT dalam PMR terhadap kemampuan Matematis lainnya dan pada berbagai level sekolah.KATA KUNCI: Local Instruction Theory; Kesulitan Belajar; Pendidikan Matematika Realistik; Siswa SMP; Berpikir Logis. ABSTRACT: “The Local Instruction Theory in Realistic Mathematics Education for Improving the Ability of Logical Thinking”. The objective of this study was to determine the Mathematical learning difficulties and differences increase students' ability to think logically whose treated by learning approach LIT (Local Instruction Theory) with RME (Realistic Mathematics Education) and students treated by PMR learning approach only. The research method in the form of design research, with research subjects totaling 184 of JHS (Junior High School) students, derived from different school rankings. The research findings show that the difficulties of learning experienced by JHS students were caused by difficult to understand the variables, coefficients, and constants; difficult to read, to interpret the intent problems, to strategize in solving problems; difficult in the process of calculation; and still wrong in writing the equation. The increasing of logical thinking ability of students in learning to use LIT with RME is higher than students whose learning by using RME only. A further study is required to see the effect of using LIT with RME towards other Mathematical skills and at various school levels.KEY WORD: Local Instruction Theory; Difficulty Learning; Realistic Mathematics Education; Junior High School Students; Logical Thinking. About the Authors: Tatang Supriatna adalah Mahasiswa SPs UPI (Sekolah Pasca Sarjana, Universitas Pendidikan Indonesia), Jalan Dr. Setiabudhi No.229 Bandung 40154, Jawa Barat, Indonesia. Prof. Dr. Darhim dan Prof. Dr. Turmudi adalah Dosen SPs UPI di Bandung. Untuk kepentingan akademik, penulis bisa dihubungi dengan alamat emel: aenwae@yahoo.co.id, darhim55@yahoo.com, dan turmudi@upi.eduHow to cite this article? Supriatna, Tatang, Darhim Turmudi. (2017). “Local Intruction Theory dalam Pendidikan Matematika Realistik untuk Menumbuhkan Kemampuan Berpikir Logis” in MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan, Vol.2(2), September, pp.173-184. Bandung, Indonesia: UPI [Indonesia University of Education] Press, ISSN 2527-3868 (print) and 2503-457X (online). Chronicle of the article: Accepted (April 26, 2017); Revised (June 30, 2017); and Published (September 30, 2017).

Hutan mangrove Langge yang terdapat di Kecamatan Anggrek Kabupaten Gorontalo Utara memiliki keunikan dari pola zonasi dan keanekaragaman jenis. Hal ini yang menjadikan hutan mangrove di kawasan tersebut sebagai objek wisata tracking mangrove yang dikenal dengan nama “mangrove in love. Hutan mangrove memiliki berbagai fungsi ekologis yang sangat kompleks yakni sebagai daerah pemijahan (spawing ground), tempat asuhan (nursery ground), dan tempat mencari makan (feeding ground) biota laut yang beraneka jenis dan memiliki fungsi ekonomis diantaranya buah mangrove dapat diolah menjadi berbagai produk kue dan sumber pangan alternatif pengganti beras. Penelitian ini bertujuan untuk : 1) untuk mengetahui komposisi jenis mangrove asosiasi; 2) untuk mengetahui struktur komunitas dari hutan mangrove Langge; dan 3) nilai Indeks Keanekaragaman. Adapun metode yang digunakan dalam penelitian ini adalah metode jalur berpetak (kombinasi plot dan transek). Jumlah spesies yang ditemukan akan dilihat untuk menjadi dasar penentuan komposisi jenis. Untuk pengkuran struktur komunitas mangrove dengan melakukan perhitungan terhadap Kerapatan Relatif (KR) dan Frekuensi Relatif (FR). Selanjutnya data yang didapatkan ditabulasikan untuk memperoleh nilai Indeks Nilai Penting (INP). Perhitungan keanekaragaman jenis menggunakan rumus (Sannon-wienner). Hasil penelitian menemukan 12 spesies tumbuhan mangrove asosiasi yakni Acanthus spinosus, Chromolaena odorata, Crassocephalum sp, Calotropis gigantean, Ipomea pes-caprae, Ricinus communis Excoecaria agallocha, Scaevola taccada, Spinifex littoreus, Terminalia catappa, Derris trifoliate dan Nypa fruticans. Struktur komunitas menunjukkan Chromolaena odorata memiliki nilai INP sebesar 33,2%, Kerapatan Relatif sebesar 24,91%, dan Frekuensi Relatif sebesar 8,33%. Spesies dengan nilai INP terendah dimiliki oleh Nypa fruticans yaitu sebesar 9,14%, Kerapatan Relatif sebesar 0,81%, dan Frekuensi Relatif sebesar 8,33%. Nilai Indeks Keanekaragaman (H’) mangrove asosiasi sebesar 2,175 dan termasuk dalam kriteria tingkat keanekaragaman sedang. Data yang diperoleh ini dapat digunakan dalam pengelolaan hutan mangrove di Gorontalo Utara serta dapat menjadi database dalam usaha konservasi mangrove guna mengurangi efek pemanasan global.Langge mangrove forest located in the District of North Gorontalo District Orchid has a uniqueness of zoning patterns and keanekragaman types. This is what makes the mangrove forests in the region as a tourist attraction tracking mangrove known as the "mangrove in love. Mangrove forests have a variety of ecological functions is very complex which is a spawning area (spawing ground), point of care (nursery grounds), and foraging (feeding ground) various types of marine life and has the economic function of which pieces of mangrove can be processed into various products cake and alternative food sources instead of rice. This study aims to: 1) to determine the association of mangrove species composition; 2) to determine the community structure of mangrove forests Langge; and 3) the value of diversity index. The method used in this study is a terraced path method (combination of plots and transects). The composition of the types of views based on the number of species found. For sizing mangrove community structure by calculating the Relative Density (KR) and Relative Frequency (FR). Then the data obtained are tabulated to get the value of Importance Value Index (IVI). Calculation of species diversity using the formula (Sannon-wienner). The study found an association of twelve species of mangrove plants and the relative dominance (DR), then the data obtained are tabulated to get the value of Importance Value Index (IVI). Calculation of species diversity using the formula (Sannon-wienner). The study found an association of eight species of mangrove plants and the relative dominance (DR), then the data obtained are tabulated to get the value of Importance Value Index (IVI). Calculation of species diversity using the formula (Sannon-wienner). The study found an association of twelve species of mangrove plantsnamely Acanthus spinosus, Chromolaena odorata, Crassocephalum sp, Calotropis gigantean, Ipomea pes-caprae, Ricinus communis Excoecaria agallocha, Scaevola taccada, Spinifex littoreus, Terminalia catappa, Derris trifoliate dan Nypa fruticans. Community structure showed Chromolaena odorata has a value of IVI of 33,2%, amounting to 24,91% Relative Density and Relative Frequency of 8,33%. The species with the lowest IVI owned by Nypa fruticans that is equal to 9,14%, 0,81% Relative Density and Relative Frequency of 8,33%. Values Diversity Index (H ') at 2.175 and mangrove associates included in the criteria for a medium level of diversity. The data obtained can be used in the management of mangrove forests in North Gorontalo and can be a database of mangrove conservation efforts to reduce the effects of global warming.

Abstract Background: Given the consistent antitumor activity and favorable toxicity profile in heavily pretreated patients, BDM represents a suitable platform for combination with target-based agents in the setting of recurrent HL. The anti-CD30 antibody-monomethyl auristatin E (MMAE) conjugate brentuximab vedotin (BV) appears a most valuable candidate by coupling an impressive clinical activity with the lack of serious overlapping toxicities with BDM. While the combination of BDM and BV is being evaluated in Phase II studies, no information is available as to possible mechanisms through which BDM may regulate the antitumor efficacy of BV towards HL cells. Methods: We evaluated the effects of acute and extended exposure to BDM on CD30 expression and sensitivity to the cytotoxic activity BV in the HL cell line L1236. Cells were cultured in the presence of BDM at its IC50 for different time points of acute exposure. Through continuous exposure to increasing concentrations (25.0, 50.0, 75.0, 100 micromol/L) of BDM, we then performed a serial in vitro selection for BDM-resistant (R) L1236 cell clones and determined their CD30 expression by flow cytometry, qRT-PCR, and Western analysis. Results: Acute exposure to BDM (48 to 72 hrs) of L1236 cells led to a sizeable upregulation of CD30 as shown by flow cytometry. This effect was unsustained since CD30 intensity returned to baseline levels upon culturing in BDM-free medium for one week. Expression of other surface antigens, i.e. HLA-DR, was unaffected by BDM while acute exposure to doxorubicin and other cytotoxic drugs did not modify the CD30 expression. We established four L1236-derived cell clones (R25, R50, R75 and R100) able to proliferate across the different concentrations of BDM with growth/viability curves superimposable to native cells. Clonal identity among clones and with parental cells was confirmed by sequencing of V3-21 (FR2/FR3) and JH3-JH4 Ig DNA regions. All R-clones displayed an up to 900% increase in CD30 median fluorescence intensity, relative to native L1236 cells (Figure 1A). The sustained CD30 upregulation was confirmed by qRT-PCR and Western blotting since R-clones expressed up to 10-fold higher levels of CD30-specific mRNA and CD30-specific 120 kDa components as compared to parental cells. To rule out a general upregulation of surface molecules as a result of the chronic exposure to BDM we evaluated the expression of other surface antigens. As opposed to CD30, HLA-DR and PDL-1 relative transcript levels and cell surface expression were significantly reduced in R-cells. Intriguingly, BDM-induced CD30 upregulation was specific to L1236 cells since extended exposure to BDM did not modify expression levels of CD30 in other lymphoma cell types (SUDHL1, JEKO). BDM-induced CD30 overexpression significantly enhanced the sensitivity of HL cells to the cytotoxic effects of BV. MTS assay showed the IC50 of R100 cells to BV shifted to 0.21 ± 0.06 mcg/mL (48 hrs) and 0.19 ± 0.05 mcg/mL (72 hrs) vs. 3.16 ± 0.75 mcg/mL (48 hrs) and 3.87 ± 0.68 mcg/mL (72 hrs) of parental cells, a 15- and 20-fold increase, respectively (p<0.001; Figure 1B). Finally, qRT-PCR studies disclosed that R-clones did not show any upregulation of the drug exporter MDR1 gene, involved in MMAE extrusion and BV resistance in HL cells, as compared to parental L1236 cells. Conclusions: Whileacute exposure to BDM induced a transient upregulation of CD30, extended exposure to the agent resulted in the selection of L1236 subclones with a stable overexpression of surface CD30 and reduced levels of HLA-DR and PDL-1. Upregulation of CD30 was associated with a significantly enhanced sensitivity to cytotoxic effects of BV. Translated into a clinical context these findings suggest that HL patients progressing upon BDM treatment may turn exquisitely sensitive to BV and prompt the exploration of a sequential treatment with BDM and BV in late and earlier disease phases. Results also provide a mechanistic insight as to the efficacy of the BDM-BV combination in HL, highlighting non-overlapping resistance pathways between BDM and MMAE. BDM-induced selection of CD30hi, HLA-DRlow/PDL-1low tumor cell clones might be relevant to the design of novel treatment strategies for HL based on the combination of BDM with BV and anti-PD1/PDL-1 antibodies. Figure 1. Expression of CD30 and HLA-DR in parental (L1236) and BDM-resistant (R) HL cells Figure 1. Expression of CD30 and HLA-DR in parental (L1236) and BDM-resistant (R) HL cells Figure 2. Sensitivity to BV of parental (L1236) and BDM-resistant (R100) HL cells Figure 2. Sensitivity to BV of parental (L1236) and BDM-resistant (R100) HL cells Disclosures Pinto: Takeda: Research Funding; Takeda, Celgene, Roche, TEVA: Honoraria.

Proyek pembangunan Gedung Parkir RSUD Dr. Soedono Madiun melakukan pengujian CPT dan SPT sekaligus untuk mendapatkan daya dukung pondasi. Oleh karena itu dua metode perhitungan daya dukung berdasarkan data CPT dan data SPT perlu dilakukan untuk dapat mengetahui perbandingan dari keduanya. Proses pengumpulan data di dalam penelitian ini dimulai dengan pengamatan data dari pengujian tanahyang terdiri dari SPT dan CPT. Pengolahan data dilakukan dengan mencari titik CPT dan SPT yang berdekatan lokasi pengujiannya, kemudian dari data CPT dicari nilai konus, JHP (Jumlah hambatan pelekat), dan rasio gesek. Sedangkan dari data SPT dicari nilai N (jumlah pukulan). Kemudian dari data tersebut dilakukan analisa daya dukung pondasinya. Hasil estimasi perkiraan jenis tanah dari data CPT secara garis besar sama dengan diskripsi visual jenis tanah dari data SPT. Hasil SPT dan CPT memberikan informasi kriteria yang sama. Hasil perhitungan daya berdasarkan data SPT dan CPT memberikan hasil yang relatif sesuai. Hasil perhitungan kapasitas daya dukung kelompok tiang pancang berdasarkan data SPT dan CPT memberikan jumlah tiang pancang yang sesuai.

Abstract The aim of this research was to evaluate the clumped model for estimating latent heat flux (LE) and actual evapotranspiration (ETa) over a non-water-stressed olive orchard. Additionally, submodels to compute the net radiation Rn, soil heat flux G, and canopy resistance were also included. For this objective, a database was used from an experimental unit inside a commercial superintensive drip-irrigated olive orchard located in the Pencahue Valley, Maule Region, Chile (35°23′S, 71°44′W; 96 m above sea level) during the 2009/10 and 2010/11 growing seasons. The evaluation was carried out using measurements of LE obtained from an eddy covariance (EC) system. In addition, estimated values of Rn, G, and were compared with ground-truth measurements from a four-way net radiometer, soil heat flux plates with soil thermocouples, and a portable porometer, respectively. Results indicated that the clumped model underestimated LE and ETa with errors of 11.0% and 3.0%, respectively. Values of the root-mean-square error (RMSE), mean bias error (MBE), and index of agreement dr for LE were 35 W m−2, −1.0 W m−2, and 0.96, while those for ETa were 0.48 mm day−1, 0.04 mm day−1, and 0.64, respectively. The submodels computed Rn and G with errors less than 6% and RMSE values less than 65 W m−2, while the Jarvis-type model predicted with RMSE = 41 s m−1 and MBE = 7.0 s m−1. Finally, a sensitivity analysis indicated that the ETa estimated by the clumped model was significantly affected by variations of ±30% in the values of the LAI and the minimum stomatal resistance rstmin.

In a recent article in this journal (JHS cvii [1987] 51–57) Garth Fowden has argued that the obelisk from Karnak erected by Constantius II in Rome in 357 had been promised to that city by his father Constantine, as Ammianus Marcellinus states, and was not originally intended, as was claimed in the (lost) inscription on its base, for Constantine's new foundation at Constantinople. The interesting suggestion is made that Constantine might have been in touch with Athenian religious experts over the matter, and the project is seen as an earnest of ‘his desire to conciliate the pagan Establishment of Old Rome’. The point of this piece is to enlarge on the possible significance of the obelisk to contemporary Christians that is hinted at by Dr Fowden.Constantine paid three visits to Rome as emperor, in 312, after winning the Battle of the Milvian Bridge, in 315 during the celebration of his Decennalia, and in 326 for his Vicennalia; on at least one of these occasions, he gave offence to non-Christian Romans by declining to perform the customary procession to the Capitol to offer sacrifice.

There is a total of 1,46,00,000 cubic kilometers of water present on the earth. Out of this, 97 percent is in the oceans, which is not useful for us due to being saline, and 1.6 percent is under the water and 0.001 percent is in the form of vapor and clouds and other glaciers and mountain peaks are in the form of ice. Even in this minimum quantity of available water, the question mark of quality is being raised at some places and the life of every living being found on earth depends on water. Hence its availability is absolutely necessary. The free or free gift of nature, which we consider water, is not free but a valuable gift. So we should understand that every drop of water is precious. If we do not use and conserve and manage water judiciously, then our very existence will be threatened. Thus, in view of the increasing water pollution and the lack of water quality, many types of campaigns and programs have been run by the government from time to time, out of which Heli-Born Survey technology, 'Jal Shakti Abhiyan: Catch the Rain' campaign on World Water Day 2022, Bhujal Badhao Payjal Bachao’ (Enhance Ground Water, Protect Drinking Water) Limca Book of Records in February 2020 is the main campaigns to improve the quality of groundwater. The Union Minister, Dr. Jitendra Singh launched the state of the art Heli-Born Survey Technology on October 5, 2021. This project has been developed with the objective of mapping potential groundwater sources and its management to provide safe drinking water to the people in water scarce arid regions of India. This project will make a positive contribution to CSIR's water technologies “Har Ghar Hal Se Jal” scheme from water source discovery to water purification as well as “doubling farmers’ income targets”.

Placing Thomas Edison at the beginning of a history on electric power transmission hardly needs justification. Thomas Edison's abundant supply of pictures of himself as an inventive genius – and America's pressing demand for a myth of an ingenious inventor – combined to bestow a “Eureka” moment upon Edison's pioneering Pearl Street (New York) Station electric lighting network. But the history of the laborious computations that took place at Menlo Park and the division-of-computing labor of which Edison took advantage suggests a different view of inventive genius. The story of the computational pyramid formed by the labors of Francis R. Upton, Charles L. Clarke, and Samuel D. Mott (1879–1880) can be reconstructed from the existing literature. In his reminiscences from Menlo Park, Edison's employee, Francis Jehl, detailed how Edison thought of constructing a miniaturized network to be used as a computer of the actual network. Knowing that constructing, maintaining, and using the miniature network required a considerable amount of skilled labor, Edison decided to hire an employee for it, Dr Herman Claudius. Edison enthusiastically welcomed Claudius to perform a type of computing work “requiring nerve and super abundance of patience and knowledge”. Jehl remembered that the labor of constructing a miniature network of conductors, “all in proportion, to show Mr Edison what he would have to install in New York City in connection with the Pearl Street Station” was “gigantic”. Following the pattern of the Pearl Street Station electric lighting network, several similar networks were built in the early 1880s. In response, Edison's labor pyramid was enlarged by giving Claudius an assistant, Hermann Lemp, who performed the monotonous task of constructing the new miniature networks, which Edison needed for computation. Inconvenient as it might be for those who assume that technological change is the product of inventive genius, electrification was, from the beginning, laboriously computed; it was not, like Athena, a deity that leapt from a godly head.

Studying an interaction between more than one variable, both in influence and action is never an easy task, but establishing a key functional observation and question is even extremely difficult to an academician. The current literature therefore tries to re-establish an empirical debate between bi-polar ends, taking the influence of human destructive-constructive ends on both variables ecosystem (E1) and economic needs (E2). Kilimanjaro has been taken to represent a case in Tanzania reflecting African 4 – zones on economic agriculture, as it represents among sectors of economy, 47 percent of GDP and employs 85 percent of Tanzanian population. The current literature refers to Global perspective as Global warming covers not only Africa but the whole world reforms platforms. Institutional suggestions therefore cover solutions in terms of theoretical and empirical reflections for both. Where economic parameters and statistical dimensions cover the most dynamic era of plans, actions and the way forward (1990s -2000s). The evils of poverty has been linked to the impacts of unbalanced Dr. Msaki’s ratio (GE1/GE2=ɼ˚), where question A and B articulate further platforms for future researched. The literature concludes by re-establishing an implementation cycle of root I and II focused on balancing criterion of ɼ˚- establishment in terms of culture, strategies, focus and policies. JEL Classifications Code: E6

The topic of the research presented is to study the awareness and aptitude of students and students towards the environment.The survey method was used for awareness, the 11th and 12th students of higher secondary school in Indore were selected by elective method. In Nyadarsh ​​400 students and 400 girls were taken from class 11th and 12th government and non-government schools. In this, Dr. for environmental awareness measurement. Made by Praveen Kumar Jha. A scale prepared by Mrs. Hasin Taj, Bangalore is used. There has been a decrease in students towards environmental awareness and aptitude. Therefore, the students should be awakened in their subconsciousness towards the environment. प्रस्तुत शोध का विषय छात्रों एवं छात्राओं की पर्यावरण के प्रति जागरूकता एवं अभिवृत्ति का अध्ययन करना है । जागरूकता जानने हेतु सर्वेक्षण विधि का प्रयोग किया इन्दौर शहर के उच्चतर माध्यमिक विद्यालय के 11 वीं एवं 12वीं के विद्यार्थियों का चयन यदृच्छिक विधि द्वारा किया गया । न्यादर्ष में 400 छात्र एवं 400 छात्राएँ कक्षा 11वीं एवं 12वीं शासकीय एवं अषासकीय विद्यालयों से लिये गये । इसमें पर्यावरण जागरूकता मापन के लिए डाॅ. प्रवीण कुमार झा द्वारा निर्मित ।ूंतमदमेे ।इपसपजल डमंेनतम एवं पर्यावरण अभिवृत्ति मापन के लिये डाॅ. श्रीमती हसीन ताज, बैंगलोर द्वारा तैयार की गई मापनी का प्रयोग किया गया है । पर्यावरण जागरूकता एवं अभिवृत्ति के प्रति विद्यार्थियों में कमी पाई गई है । अतएव विद्यार्थियों में पर्यावरण के प्रति अवचेतना को जागृत किया जायें ।

Journal of Agricultural Studies (JAS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JAS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 9, Number 1Ahmed Mohamed Elbeltagi, Mansoura University, EgyptAi-Ping Wu, Hunan Agricultural University, ChinaAlessandra M. Lima Naoe, Federal University of Tocantins, BrazilAlexandra-Nadia Cirdei, Technical University of Civil Engineering of Bucharest, RomaniaAlexandru Ioan Apahidean, UASVM, RomaniaAna Daniela Lopes, Universidade Paranaense, BrazilAnca-Luiza Stanila, ICPA, RomaniaAngel Ramon Sanchez Delgado, Universidade federal Rural do Rio de Janeiro, BrazilArnaud Z. Dragicevic, IRSTEA, FranceBenard Kiplangat Rop, University of Nairobi, KenyaCleber Duarte, University of Guararapes, BrazilDarwin Pangaribuan, University of Lampung, IndonesiaEben von Well, Agricultural Research Council, South AfricaEric Krawczyk, University of Michigan, USAEric Owusu Danquah, CSIR-Crops Research Institute, GhanaFábio Cassola, UNICAMP, BrazilFernando Coelho Eugenio, Federal University of Santa Maria, BrazilGuitong Li, China Agricultural University, ChinaHabu Saleh Hamisu, National Horticultural Research Institute, NigeriaHedayatollah K. Soureshjani, Ferdowsi University of Mashhad, IranJanerson Jose Coelho, Universidade Federal Rural de Pernambuco, BrazilJoão Manoel da Silva, Universidade Federal de Alagoas, BrazilJorge A. López, University Tiradentes, BrazilMahyar Gerami, Sana Institute of Higher Education, IranMaría Elena Estrada Martínez, Universidad Metropolitana, EcuadorMaría Francisca Perera, ITANOA, EEAOC-CONICET, ArgentinaMariana Esteves, Luiz de Queiroz College of Agriculture University of Sao Paulo, BrazilMd. Sadique Rahman, Sher-e-Bangla Agricultural University, BangladeshNeha Jha, Massey University New Zealand, New ZealandNkemkanma Vivian Agi, Rivers State University Port Harcourt, NigeriaOlga Mykhailenko, National University of Pharmacy, UkraineOscar Mitsuo Yamashita, Universidade do Estado de Mato Grosso, BrazilRaul Pașcalău, BUASVM, RomaniaSaiful Irwan Zubairi, Universiti Kebangsaan Malaysia (UKM), MalaysiaSamir Neggaz, Université Oran, AlgeriaSarir Ahmad, Abdul Wali Khan University, PakistanShakirudeen Abimbola Lawal, University of Cape Town, South AfricaShubha Kumari, ICAR-RCER, IndiaSomaia Alkhair, Alzaeim Alazhari University, SudanSybelle Mesquita Silva, Universidade Federal de Alagoas, BrazilToncho Gospodinov Penev, Trakia University, BulgariaUtkarsh R. Moon, Mahatma Gandhi College of Science, IndiaWossenie Shibabaw Mebratie, Bahir Dar University, EthiopiaZakaria Fouad Abdallah, National Research Centre, EgyptZhao Chen, Clemson University, USA Richard WilliamsEditorial AssistantJournal of Agricultural Studies--------------------------------------Macrothink Institute5348 Vegas Dr.#825Las Vegas, Nevada 89108United StatesPhone: 1-702-953-1852 ext.521Fax: 1-702-420-2900Email 1: jas@macrothink.orgEmail 2: jas@macrothink.comURL: http://jas.macrothink.org

Abstract DuoBody®-CD3xCD20 (GEN3013) is a bispecific antibody (bsAb), recognizing the T-cell antigen CD3 and the B-cell antigen CD20, that triggers potent T-cell-mediated lysis of CD20-expressing cells. DuoBody-CD3xCD20 is a full-length bispecific IgG1 generated by controlled Fab-arm exchange (cFAE) [1, 2] and contains an effector function-silenced Fc region. In vitro, DuoBody-CD3xCD20 induced potent activation, proliferation and cytotoxic activity of both CD4+ and CD8+ T cells in the presence of CD20-expressing cells, as measured by flow cytometry and bromodeoxyuridine (BrdU) incorporation assays. DuoBody-CD3xCD20 induced T-cell-mediated cytotoxicity towards a diverse panel of cell lines derived from various B-cell malignancies and endogenous B cells, with EC50 values in the low picomolar range (EC50: 0.2-5.0 pM). The CD20-specific antibody 7D8 [3-5] forms the basis for the CD20-specific Fab arm of DuoBody-CD3xCD20. To study the contribution of this specific Fab arm to the observed potency of DuoBody-CD3xCD20, we compared the target binding characteristics and the capacity to induce T-cell-mediated cytotoxicity of a CD3 bsAb based on 7D8, with CD3 bsAbs using B-cell targeting arms derived from alternative CD20 antibodies or from antibodies against other well-known B-cell membrane molecules CD22, CD24, CD37, CD70, CD79b, CD138 and HLA-DR. In addition, target expression levels of the B-cell targets were assessed in a panel of B-cell lines. Using a classic chromium release assay, the 7D8-based CD3 bsAb displayed cytotoxic activity superior to all other B-cell-targeting CD3 bsAbs tested, including alternative CD20-targeting CD3 bsAbs. This unique cytotoxic activity could not be explained by expression levels of the target antigen, nor by the binding affinity or epitope of the B-cell specific Fab arm. This illustrates the complexity of factors that determine the potency of CD3 bsAbs. The anti-tumor activity of DuoBody-CD3xCD20 was confirmed in vivo in humanized mouse models using three different B-cell lymphoma xenograft models, in prophylactic and therapeutic settings. Non-clinical safety studies with DuoBody-CD3xCD20 in cynomolgus monkeys demonstrated profound and long-lasting B-cell depletion (at least 70 days, at dose levels > 0.1 mg/kg) from both peripheral blood and lymphoid organs. B-cell depletion was reversible, with time to B-cell recovery correlating with the treatment dose. Notably, at the same dose level, B-cell depletion was comparable between subcutaneous and intravenous administration. Pharmacokinetic (PK) analysis demonstrated comparable bioavailability for the two administration routes, although peak plasma levels were lower and delayed after subcutaneous administration. Moreover, lower plasma cytokine levels were observed after subcutaneous administration. Based on these data, Genmab has initiated a First-in-Human clinical trial to evaluate the safety and preliminary efficacy of DuoBody-CD3xCD20 by subcutaneous administration in patients with B-cell malignancies. The study is currently enrolling (EudraCT No: 2017-001748-36). References Labrijn, A.F., et al., Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange. Proc Natl Acad Sci U S A, 2013. 110(13): p. 5145-50. Labrijn, A.F., et al., Controlled Fab-arm exchange for the generation of stable bispecific IgG1. Nat Protoc, 2014. 9(10): p. 2450-63. Teeling, J.L., et al., Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood, 2004. 104(6): p. 1793-800. Teeling, J.L., et al., The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20. Journal of Immunology, 2006. 177(1): p. 362-71. van Meerten, T., et al., HuMab-7D8, a monoclonal antibody directed against the membrane-proximal small loop epitope of CD20 can effectively eliminate CD20 low expressing tumor cells that resist rituximab-mediated lysis. Haematologica, 2010. 95(12): p. 2063-71. Disclosures Hiemstra: Genmab: Employment, Other: Warrants. Engelberts:Genmab: Employment, Other: Warrants. de Jong:Genmab: Employment, Other: Warrants. Schuurhuis:Genmab: Employment, Other: Warrants. Salcedo:Genmab: Employment, Other: Warrants. Verploegen:Genmab: Employment, Equity Ownership. van der Zee:Genmab: Employment, Other: Warrants. Gerritsen:Genmab: Employment, Other: Warrants. Losic:Genmab: Employment, Other: Warrants. Horbach:Genmab: Employment, Other: Warrants. Oliveri:Genmab: Employment, Other: Warrants. Lammerts van Bueren:Genmab: Employment, Other: Warrants. Autzen Usher:Genmab: Employment, Other: Warrants. Schuurman:Genmab: Employment, Other: Warrants. Parren:Genmab: Equity Ownership; Lava Therapeutics: Employment. Breij:Genmab: Employment, Equity Ownership.

Abstract STUDY QUESTION Does female weekly alcohol intake and binge drinking impact the chance of a successful fertility treatment? SUMMARY ANSWER Low-to-moderate weekly alcohol drinking and binge drinking were not associated with the chance of achieving a clinical pregnancy or a live birth among women and couples undergoing medically assisted reproduction (MAR) treatments. WHAT IS KNOWN ALREADY Alcohol consumption is common among women of reproductive age, even though health authorities advise women trying to conceive to abstain from drinking. A growing number of couples struggle with infertility, but it is unknown whether low-to-moderate levels of alcohol consumption and alcohol binge drinking impair success in fertility treatment. STUDY DESIGN, SIZE, DURATION Cohort study with prospectively collected exposure information including 1708 women and potential partners undergoing fertility treatment at the public fertility clinic, Aarhus University Hospital, 1 January 2010 to 31 August 2015. In total, data on 1511 intrauterine insemination (IUI) cycles, 2870 in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles and 1355 frozen embryo transfer cycles. PARTTICIPANTS/MATERIALS, SETTING, METHODS Exposure to weekly average alcohol intake was assessed from questionnaires completed by participants before the start of treatment. Outcome measures are the achievement of a clinical pregnancy and live birth in consecutive treatment cycles in the Danish national health registries, enabling complete follow-up. A modified Poisson regression with robust standard errors was used to evaluate associations between a weekly average alcohol intake and MAR outcomes, adjusting for female age, body mass index, cigarette smoking, coffee consumption, chronic diseases, level of education, and cycle number. When evaluating the association between binge drinking in the month prior to baseline and MAR outcomes the analyses were further adjusted for average weekly alcohol consumption. MAIN RESULTS AND THE ROLE OF CHANCE Low-to-moderate average weekly alcohol intake was not statistically significantly associated with the chance of achieving a clinical pregnancy or a live birth following IUI or IVF/ICSI treatment cycles. Compared to women abstaining from alcohol, the adjusted relative risks for achieving a live birth among those reporting 1–2, 3–7, and &gt;7 drinks per week were 1.00 (95% CI 0.66; 1.53), 1.20 (0.76; 1.91), and 1.48 (0.56; 3.93), respectively, among women initiating IUI treatments. Among those initiating IVF/ICSI treatments, the chance for achieving a live birth among those reporting 1–2, 3–7, and &gt;7 drinks per week were 1.00 (0.83; 1.21), 0.95 (0.75; 1.20), and 0.89 (0.53; 1.51), respectively. The chance of achieving a live birth in the first IUI or IVF/ICSI treatment cycle was unrelated to the number of binge drinking episodes in the month preceding baseline. LIMITATIONS, REASONS FOR CAUTION The risk of non-differential exposure misclassification, confounding, or chance cannot be ruled out. In addition, due to the low number of women reporting an intake of &gt;7 drinks/week, the potential effect of high alcohol consumption should be interpreted with caution. WIDER IMPLICATIONS OF THE FINDINGS Although it remains unsettled if and how alcohol affects female reproduction, our results indicate that is not necessary to abstain from alcohol when striving for a successful outcome following fertility treatment. STUDY FUNDING/COMPETING INTEREST(S) J.L. is supported by a fully financed Ph.D. scholarship from Aarhus University and has received funds from the A.P. Møller foundation. The funding sources had no involvement in the conduct of the article. Dr Kesmodel reports personal fees from MSD and Ferring Pharmaceuticals outside the submitted work. All other authors have no conflicts of interest to declare and all have completed the ICMJE disclosure form. TRIAL REGISTRATION NUMBER Not relevant.

AbstractProf. Dr. Dimitar T. Hrisoho was born on June 11, 1924 in Bitola, R. Macedonia. He died in Struga on September 22, 1986, and was buried in Skopje.He completed primary and secondary education in Bitola. He graduated from the Medical Faculty in Belgrade in 1951 as one of the best students of his generation (average grade of 9.75). In 1953 he was employed at the Internal Clinic of the Medical Faculty in Skopje, where in 1955 he passed the specialist exam in internal medicine. He successfully defended his habilitation “Polyarthritis chronica evolutiva” and his doctoral dissertation “Clinical features of Vitina nephropathy”. The doctoral dissertation indicates that Vitina nephropathy is a new site of the Balkan Endemic Nephropathy entity and that more genetic testing of patients were needed. Based on numerous clinical and scientific researches published in over 200 papers, he was elected a Full Professor of internal medicine at the Medical Faculty of the Ss. Cyril and Methodius University in Skopje in 1971. In 1970, he formed the nephrology section of the Macedonian Medical Association (MMA), which grew into the nephrology Association of MMA. Through the Association, the education of the medical staff from the field of nephrology was performed. He also set up a bio-cybernetics association.He achieved his vision and desire to transfer and apply the achievements of modern nephrology in the diagnosis and treatment of kidney patients in Macedonia at the Clinic of Nephrology of the Medical Faculty in Skopje, which was the first specialized institution established for examination and treatment of kidney patients in the former Yugoslavia and the Balkans. The Clinic educated nephrological staff and examined and treated kidney patients with new methods and drugs that positively affected the development of nephrology as a subspecialty of the internal medicine. D. Hrisoho was actively involved in the introduction of new methods for examination of kidney patients, as well as in the treatment of patients with acute and chronic renal insufficiency with dialysis since 1965. He also participated in the first two kidney transplantations from living donors performed in 1977. He wrote a chapter on “kidney examination”, printed in the book of Prof. A. J. Ignjatovski “Fundamentals of Internal Propedeutics” Part III, published by “Prosvetno delo”, 1963, in Skopje. This is the first text to investigate a patient with kidney disease published in a textbook in R. Macedonia. In 1984 he published the textbook “Clinical Nephrology” printed by the University of the Ss. Cyril and Methodius University in Skopje.Prof. D. Hrisoho organized the First Scientific Meeting of Yugoslav Nephrologists with international participation, from 26 to 28 September 1977, in Struga, R. Macedonia. The meeting was attended by prominent nephrologists from the former Yugoslavia, the Balkans, Europe and the United States, among them: J.S. Cameron from UK, J.L. Funck-Brentano from France, M. Burg and P. Ivanovich from the USA, R. Kluthe from Germany and A. Puchlev from Bulgaria. The scientific meeting was the largest nephrology event until then organized in the former Yugoslavia. The meeting provided an exchange of experiences with world-renowned nephrologists. D. Hrisoho presented the paper Artificial intelligence in nephrology. The author tried to apply bio-cybernetics in nephrology. Prof. D. Hrisoho was Vice Dean of the Medical Faculty in Skopje in the period 1963-1965 and Vice Rector of the University of the Ss. Cyril and Methodius University in Skopje in the period 1974-1975. Prof. Hrisoho was also active in socio-political organizations. For his medical, educational and scientific activities he received several awards and recognitions in the country and abroad. Thus, the work of Prof. D. Hrisoho was permanently embedded in the nephrology of R. Macedonia.

Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. 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Abstract This study sets out several phonological features in Caijia that are notable from a diachronic point of view. The Caijia language is an endangered language spoken in northwestern Guìzhōu, China. It was first formally documented in the early 1980s and is generally viewed as a Sinitic language. Some aspects of Caijia phonology are noteworthy from the perspective of historical phonology. There exist features which cannot be accounted for in terms of Middle Chinese (MC), such as the retention of the contrast between Old Chinese (OC) T-type and L-type onsets in words with d- or dr- in Middle Chinese. Moreover, Caijia also demonstrates features which are observed or preserved in Middle Chinese, but absent in mainstream modern Sinitic varieties, including the retention of bilabial stops in words with initials Fēi/Fū/Fèng. This study will also explore the implications certain phonological features have for the classification of Caijia in the Sinitic clade and examine the relationship between Caijia and Bai.

Sareum enters co-development agreement in China for Aurora+FLT3 program. Helsinn Group opens representative office in China. Biotech China to be held in Nanjing Clinic's Center for individualized medicine. Shanghai Ajinomoto Amino Acid Co., Ltd. expands amino acid production capacity. Agilent Technologies Thought Leader Award supports Dr. Junying Yuan, Chinese Academy of Sciences. to-BBB and Sihuan enter into collaboration agreement. JHL Biotech selects GE's FlexFactory™ bio manufacturing platform for Taiwan facility. Senhwa Biosciences raises $17M in Series B. New bat virus in China can infect people. Chi-Med and Sinopharm form China drug distribution and marketing joint venture. MicuRx expands global clinical trial program for oral antibiotic MRX-I. TaiGen Biotechnology receives Qualified Infectious Disease Product and Fast Track designations from the U.S. FDA.

Our policy is to annotate all English-language books on economics and related subjects that are sent to us. A very small number of foreign-language books are called to our attention and annotated by our consulting editors or others. Our staff does not monitor and order books published; therefore, if an annotation of a book does not appear six months after the publication date, please write to us or the publisher concerning the book. An Index of Authors of New Books appearing in the Annotated Listings will appear at the end of the General Index in the December issue. The annotations appearing in this section were written by Ms. Ann Norman. The articles appearing in the Subject Index in e-JEL, JEL on CD, and EconLit were classified under the direction of Professor Asatoshi Maeshiro, Editorial Consultant, assisted by Ms. Helen Lafferty, Dr. Charles McCann, Dr. Manhar Vyas, Ms. Jane Caldwell Wallace, Dr. Jerry Wells, and Ms. Katherine Wolfe.

Our policy is to annotate all English-language books on economics and related subjects that are sent to us. A very small number of foreign-language books are called to our attention and annotated by our consulting editors or others. Our staff does not monitor and order books published; therefore, if an annotation of a book does not appear six months after the publication date, please write to us or the publisher concerning the book. An Index of Authors of New Books appearing in the Annotated Listings will appear at the end of the General Index in the December issue. The annotations appearing in this section were written by Ms. Ann Norman. The articles appearing in the Subject Index in e-JEL, JEL on CD, and EconLit were classified under the direction of Professor Asatoshi Maeshiro, Editorial Consultant, assisted by Ms. Helen Lafferty, Dr. Charles McCann, Dr. Manhar Vyas, Ms. Jane Caldwell Wallace, Dr. Jerry Wells, and Ms. Katherine Wolfe.

Our policy is to annotate all English-language books on economics and related subjects that are sent to us. A very small number of foreign-language books are called to our attention and annotated by our consulting editors or others. Our staff does not monitor and order books published; therefore, if an annotation of a book does not appear six months after the publication date, please write to us or the publisher concerning the book. An Index of Authors of New Books appearing in the Annotated Listings will appear at the end of the General Index in the December issue. The annotations appearing in this section were written by Ms. Ann Norman. The articles appearing in the Subject Index in e-JEL, JEL on cd, and EconLit were classified under the direction of Professor Asatoshi Maeshiro, Editorial Consultant, assisted by Ms. Helen Lafferty, Dr. Charles McCann, Dr. Manhar Vyas, Ms. Jane Caldwell Wallace, Dr. Jerry Wells, and Ms. Katherine Wolfe.

This article answers Dr. Humphrey contention on the similarities between monetarist and Austrian approaches to the neutrality of money. Monetarists at most only concentrate on short term non neutrality while Austrians base their analysis in short, medium and long term non neutrality. For the more, monetarists lack a true theory of capital that could let then understand thet even with flexible markets money would not be neutral in the short term. Key words: Economic cycles, neutrality of money, short and long term effects of money, capital theory. JEL Classification: B53, B49, D01, K13. Resumen: El presente artículo contesta la tesis del Dr. Humphrey según la cual las diferencias entre austriacos y monetaristas son ficticias pues algunos de éstos también reconocieron los efectos distorsionadores del crecimiento monetario sobre los precios relativos. El artículo demuestra que la teoría austriaca considera que el dinero no es neutral ni a corto, ni a medio ni a largo plazo y ello contrasta con el enfoque monetarista que solo reconoce la no neutralidad a corto plazo y por razones equivocadas al carecer de una verdadera teoría del capital. Palabras clave: Ciclo económico, neutralidad del dinero, corto plazo, largo plazo, teoría del capital. Clasificación JEL: B53, B49, D01, K13.

Street in urban areas has an important function to support human activity and social interaction. That matter can be achieved by a good streetscape planning based on regulations and standards for streetscape design. The aim of streetscape planning is to give safety and amenities for street user in urban area. This research took place in Dr. Muwardi street Denpasar. Dr. Muwardi street’s located inside Denpasar City civic center well known as Niti Mandala area. Lack of streetscape planning makes street activities unorganized. A number of street vendors that attract visitor with personal transportation caused a street dysfunction. This study aims to design a good streetscape, and optimize the potential and solve the problems in Dr. Muwardi street. The research used a descriptive qualitative methode through inventory, analysis, synthesis, concept making, planning, and pre-design phase. The result shown that the street design was devided into trading space, pedestrian space, and traffic space. Trading spaces organized by rearrange the street vendor trading zone. Pedestrian space designed by adding sidewalk and street amenities, meanwhile traffic area designed by adjusting streetscape standart into the site. To enchance local characteristic and aesthetic value to the streetscape, additional street landscape trees from Gumi Banten plant list is applied.