Log in

Relevant bibliographies by topics / Drivers of resistance / Journal articles

To see the other types of publications on this topic, follow the link: Drivers of resistance.

Journal articles on the topic 'Drivers of resistance'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Drivers of resistance.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Zhanel, George G. "Antibacterial Drivers of Resistance." Treatments in Respiratory Medicine 4, Supplement 1 (2005): 13???18. http://dx.doi.org/10.2165/00151829-200504001-00005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Harbarth, S. "Global drivers of antibiotic resistance." International Journal of Infectious Diseases 21 (April 2014): 63. http://dx.doi.org/10.1016/j.ijid.2014.03.552.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Schuster, Amy, Jenna Van Fossen, Danielle Sperry, and Shelia Cotten. "Fear, Resistance, or Anticipation? Older Truck Drivers’ Reactions to the Adoption of Automated Vehicles." Innovation in Aging 5, Supplement_1 (2021): 969. http://dx.doi.org/10.1093/geroni/igab046.3491.

Full text

Abstract:

Abstract The forecasted adoption of autonomous vehicles (AVs) will lead to major changes to the job of truck driving. These changes may be particularly challenging for drivers, as the population of truck drivers skews much older than that of other occupations. In this study we sought to understand truck drivers’ attitudes towards AVs and the longevity of their job. We conducted focus groups with truck drivers, their supervisors, and upper-level managers of trucking companies. We relate supervisors’ and managers’ experiences working with drivers through the rollout of new technologies to furthe

APA, Harvard, Vancouver, ISO, and other styles

4

Knebel, Franciele H., Louise J. Barber, Alice Newey, et al. "Circulating Tumour DNA Sequencing Identifies a Genetic Resistance-Gap in Colorectal Cancers with Acquired Resistance to EGFR-Antibodies and Chemotherapy." Cancers 12, no. 12 (2020): 3736. http://dx.doi.org/10.3390/cancers12123736.

Full text

Abstract:

Epidermal growth factor receptor antibodies (EGFR-Abs) confer a survival benefit in patients with RAS wild-type metastatic colorectal cancer (mCRC), but resistance invariably occurs. Previous data showed that only a minority of cancer cells harboured known genetic resistance drivers when clinical resistance to single-agent EGFR-Abs had evolved, supporting the activity of non-genetic resistance mechanisms. Here, we used error-corrected ctDNA-sequencing (ctDNA-Seq) of 40 cancer genes to identify drivers of resistance and whether a genetic resistance-gap (a lack of detectable genetic resistance m

APA, Harvard, Vancouver, ISO, and other styles

5

de Wit, Matthijs, Mirella Kleijnen, Birgit Lissenberg-Witte, et al. "Understanding Drivers of Resistance Toward Implementation of Web-Based Self-Management Tools in Routine Cancer Care Among Oncology Nurses: Cross-Sectional Survey Study." Journal of Medical Internet Research 21, no. 12 (2019): e14985. http://dx.doi.org/10.2196/14985.

Full text

Abstract:

Background Supporting patients to engage in (Web-based) self-management tools is increasingly gaining importance, but the engagement of health care professionals is lagging behind. This can partly be explained by resistance among health care professionals. Objective The aim of this study was to investigate drivers of resistance among oncology nurses toward Web-based self-management tools in cancer care. Methods Drawing from previous research, combining clinical and marketing perspectives, and several variables and instruments, we developed the Resistance to Innovation model (RTI-model). The RT

APA, Harvard, Vancouver, ISO, and other styles

6

Vasudevan, Krishnan, and Ngai Keung Chan. "Gamification and work games: Examining consent and resistance among Uber drivers." New Media & Society 24, no. 4 (2022): 866–86. http://dx.doi.org/10.1177/14614448221079028.

Full text

Abstract:

In 2018, Uber released an overhauled mobile application for its independent contractor workforce, who had become increasingly dissatisfied by the lack of autonomy, transparency, and flexibility while working on the platform. Based on the gamification of work, the application linked individualized rewards with Uber’s need to maintain a frictionless marketplace. However, as recent studies of gig economy have revealed, workers resist gamified algorithmic management by developing work games. Our findings, based upon analysis of driver accounts of using Uber’s application, presents a typology of pl

APA, Harvard, Vancouver, ISO, and other styles

7

Najafi, Masoud, Keywan Mortezaee, and Jamal Majidpoor. "Cancer stem cell (CSC) resistance drivers." Life Sciences 234 (October 2019): 116781. http://dx.doi.org/10.1016/j.lfs.2019.116781.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Egberi, Kelvin Agbarha, and Lucky Edafetano Oboreh. "Do Global Competitiveness, Cultural Resistance and Capital Financing Drive Value Creation?" International Journal of Professional Business Review 8, no. 4 (2023): e0516. http://dx.doi.org/10.26668/businessreview/2023.v8i4.516.

Full text

Abstract:

Purpose: While value creation has long been a target for most economies of the world, only recently have certain macroeconomic and socio-economic practicalities been discovered to play key roles in propelling value creation. Amazingly, this is a topical theme characterized by a rareness of both theoretical and empirical researches. Thus, the aim of this paper is to assess whether microeconomic and socio-economic practicalities (what has been termed as global competitiveness, capital financing and cultural resistance) drive value creation. Theoretical Framework: The theoretical framework is hin

APA, Harvard, Vancouver, ISO, and other styles

9

Freiberger, Sandra N., Patrick Turko, Martin Hüllner, et al. "Who’s Driving? Switch of Drivers in Immunotherapy-Treated Progressing Sinonasal Melanoma." Cancers 13, no. 11 (2021): 2725. http://dx.doi.org/10.3390/cancers13112725.

Full text

Abstract:

Mucosal melanoma can be driven by various driver mutations in genes such as NRAS, KIT, or KRAS. However, some cases present with only weak drivers, or lacking known oncogenic drivers, suggesting immunotherapy over targeted therapy. While resistance mechanisms to immunotherapy in cutaneous melanoma have been uncovered, including alterations in JAK1/2, B2M, or STK11, a switch of oncogenic drivers under immunotherapy has not yet been observed. We report three cases of metastatic sinonasal melanoma that switched oncogenic drivers from KRAS, KIT, or no driver to NRAS during or after immunotherapy,

APA, Harvard, Vancouver, ISO, and other styles

10

Arubayi, Daniel. "Documenting the Everyday Hidden Resistance of Ride-Hailing Platform Drivers to Algorithmic Management in Lagos, Nigeria." South Atlantic Quarterly 120, no. 4 (2021): 823–38. http://dx.doi.org/10.1215/00382876-9443378.

Full text

Abstract:

Ride-hailing platforms such as Uber, an integral component in the global platform economy, are not only facilitating fluidity and so-called autonomy of labor; they are also creating an unfair working environment for workers. This phenomenon indicates the strength of a highly temporal and mobile capital, pitted against workers not just in Lagos but around the world. This article adopts James Scott’s notion of everyday resistance in exposing some of the hidden practices of platform drivers in Lagos. It finds that sabotaging and falsely complying through manipulating algorithms and gaming spaces

APA, Harvard, Vancouver, ISO, and other styles

11

Irfan, Mohammad, Alhomidi Almotiri, and Zeyad Abdullah AlZeyadi. "Antimicrobial Resistance and Its Drivers—A Review." Antibiotics 11, no. 10 (2022): 1362. http://dx.doi.org/10.3390/antibiotics11101362.

Full text

Abstract:

Antimicrobial resistance (AMR) is a critical issue in health care in terms of mortality, quality of services, and financial damage. In the battle against AMR, it is crucial to recognize the impacts of all four domains, namely, mankind, livestock, agriculture, and the ecosystem. Many sociocultural and financial practices that are widespread in the world have made resistance management extremely complicated. Several pathways, including hospital effluent, agricultural waste, and wastewater treatment facilities, have been identified as potential routes for the spread of resistant bacteria and thei

APA, Harvard, Vancouver, ISO, and other styles

12

Mani, Zied, and Inès Chouk. "Drivers of consumers’ resistance to smart products." Journal of Marketing Management 33, no. 1-2 (2016): 76–97. http://dx.doi.org/10.1080/0267257x.2016.1245212.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Kelsey, Rebecca. "Genomic drivers of resistance to AR therapies." Nature Reviews Urology 15, no. 4 (2018): 202. http://dx.doi.org/10.1038/nrurol.2018.18.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Becker, Jeremias Martin, Renato Russo, Naeem Shahid, and Matthias Liess. "Drivers of pesticide resistance in freshwater amphipods." Science of The Total Environment 735 (September 2020): 139264. http://dx.doi.org/10.1016/j.scitotenv.2020.139264.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Johnson, Andrew M. F., and Jerrold M. Olefsky. "The Origins and Drivers of Insulin Resistance." Cell 152, no. 4 (2013): 673–84. http://dx.doi.org/10.1016/j.cell.2013.01.041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Theuretzbacher, U. "Ecology and environmental drivers of antimicrobial resistance." International Journal of Infectious Diseases 53 (December 2016): 31. http://dx.doi.org/10.1016/j.ijid.2016.11.084.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Rubanov, Andrey, Pietro Berico, and Eva Hernando. "Epigenetic Mechanisms Underlying Melanoma Resistance to Immune and Targeted Therapies." Cancers 14, no. 23 (2022): 5858. http://dx.doi.org/10.3390/cancers14235858.

Full text

Abstract:

Melanoma is an aggressive skin cancer reliant on early detection for high likelihood of successful treatment. Solar UV exposure transforms melanocytes into highly mutated tumor cells that metastasize to the liver, lungs, and brain. Even upon resection of the primary tumor, almost thirty percent of patients succumb to melanoma within twenty years. Identification of key melanoma genetic drivers led to the development of pharmacological BRAFV600E and MEK inhibitors, significantly improving metastatic patient outcomes over traditional cytotoxic chemotherapy or pioneering IFN-α and IL-2 immune ther

APA, Harvard, Vancouver, ISO, and other styles

18

Mu, Ping, Xiaoling Li, Yunguan Wang, Tao Wang, and Su Deng. "Abstract 93: An endogenous molecular brake preventing APOBEC-driven tumor mutational burden, heterogeneity and therapy resistance." Cancer Research 83, no. 7_Supplement (2023): 93. http://dx.doi.org/10.1158/1538-7445.am2023-93.

Full text

Abstract:

Abstract Tumor mutational burden and heterogeneity fuel resistance to many targeted therapies, which inevitably limits the clinical outcome of patients. The cytosine deaminase APOBEC proteins are major drivers of mutagenesis in human cancer, with over 70% of tumors exhibiting a mutational signature that is impacted by APOBEC activity. Nevertheless, the mechanisms through which tumor cells hijack the powerful APOBEC mutagenesis machinery to promote heterogeneity and therapy resistance remain largely unknown. Through a multi-disciplinary approach integrating bulk and single cell RNA-Seq (scRNA-S

APA, Harvard, Vancouver, ISO, and other styles

19

Mu, Ping, Xiaoling Li, and Yunguan Wang. "Abstract PR001: An endogenous molecular brake preventing APOBEC-driven tumor mutational burden, heterogeneity and AR therapy resistance." Cancer Research 83, no. 11_Supplement (2023): PR001. http://dx.doi.org/10.1158/1538-7445.prca2023-pr001.

Full text

Abstract:

Abstract Tumor mutational burden and heterogeneity fuel resistance to many targeted therapies, which inevitably limits the clinical outcome of patients. The cytosine deaminase APOBEC proteins are major drivers of mutagenesis in human cancer, with over 70% of tumors exhibiting a mutational signature that is impacted by APOBEC activity. Nevertheless, the mechanisms through which tumor cells hijack the powerful APOBEC mutagenesis machinery to promote heterogeneity and therapy resistance remain largely unknown. Through a multi-disciplinary approach integrating bulk and single cell RNA-Seq (scRNA-S

APA, Harvard, Vancouver, ISO, and other styles

20

DAS, B. K., A. K. BERA, and D. K. MEENA. "Antimicrobial resistance (AMR): Differential drivers across the ecosystem." Indian Journal of Animal Health 59, no. 1 (2020): 17. http://dx.doi.org/10.36062/ijah.59.1.2020.17-21.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Durrance-Bagale, Anna, Anne-Sophie Jung, Gasto Frumence, et al. "Framing the Drivers of Antimicrobial Resistance in Tanzania." Antibiotics 10, no. 8 (2021): 991. http://dx.doi.org/10.3390/antibiotics10080991.

Full text

Abstract:

Despite global awareness of the key factors surrounding antimicrobial resistance (AMR), designing and implementing policies to address the critical issues around the drivers of AMR remains complex to put into practice. We identified prevalent narratives and framing used by epistemological communities involved in the response to AMR in Tanzania, interrogated how this framing may inform policymaking, and identified interventions that could be tailored to the groups believed responsible for AMR. We interviewed 114 key informants from three districts and analysed transcripts line by line. Our resu

APA, Harvard, Vancouver, ISO, and other styles

22

&NA;. "Drivers of antibacterial resistance key to better control." Inpharma Weekly &NA;, no. 1483 (2005): 2. http://dx.doi.org/10.2165/00128413-200514830-00002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Swift, Benjamin M. C., Malcolm Bennett, Katie Waller, et al. "Anthropogenic environmental drivers of antimicrobial resistance in wildlife." Science of The Total Environment 649 (February 2019): 12–20. http://dx.doi.org/10.1016/j.scitotenv.2018.08.180.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Holmes, Alison H., Luke S. P. Moore, Arnfinn Sundsfjord, et al. "Understanding the mechanisms and drivers of antimicrobial resistance." Lancet 387, no. 10014 (2016): 176–87. http://dx.doi.org/10.1016/s0140-6736(15)00473-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Vikesland, Peter, Emily Garner, Suraj Gupta, Seju Kang, Ayella Maile-Moskowitz, and Ni Zhu. "Differential Drivers of Antimicrobial Resistance across the World." Accounts of Chemical Research 52, no. 4 (2019): 916–24. http://dx.doi.org/10.1021/acs.accounts.8b00643.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Lee, Hyo-Keun. "The Relationship between Innovative Technology and Driver’s Resistance and Acceptance Intention for Sustainable Use of Automobile Self-Driving System." Sustainability 14, no. 16 (2022): 10129. http://dx.doi.org/10.3390/su141610129.

Full text

Abstract:

The purpose of this study was to empirically analyze the relationship between the characteristics of innovative technology, innovation resistance, and acceptance intention of automobile autonomous driving systems by applying the technology acceptance model (TAM), a representative innovative technology in the era of the 4th Industrial Revolution. A survey was conducted on drivers living in Seoul, Korea, and the following main results were derived based on the survey data for 567 people. First, the perceived usefulness and perceived ease of use of the autonomous driving system were found to have

APA, Harvard, Vancouver, ISO, and other styles

27

Ellis, David A., George Avraam, Astrid Hoermann, et al. "Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae." PLOS Genetics 18, no. 6 (2022): e1010244. http://dx.doi.org/10.1371/journal.pgen.1010244.

Full text

Abstract:

Gene drives for mosquito population modification are novel tools for malaria control. Strategies to safely test antimalarial effectors in the field are required. Here, we modified the Anopheles gambiae zpg locus to host a CRISPR/Cas9 integral gene drive allele (zpgD) and characterized its behaviour and resistance profile. We found that zpgD dominantly sterilizes females but can induce efficient drive at other loci when it itself encounters resistance. We combined zpgD with multiple previously characterized non-autonomous payload drives and found that, as zpgD self-eliminates, it leads to conve

APA, Harvard, Vancouver, ISO, and other styles

28

Cousins, Melanie, E. Jane Parmley, Amy L. Greer, et al. "Is scientific evidence enough? Using expert opinion to fill gaps in data in antimicrobial resistance research." PLOS ONE 18, no. 8 (2023): e0290464. http://dx.doi.org/10.1371/journal.pone.0290464.

Full text

Abstract:

Background Antimicrobial Resistance (AMR) is a global problem with large health and economic consequences. Current gaps in quantitative data are a major limitation for creating models intended to simulate the drivers of AMR. As an intermediate step, expert knowledge and opinion could be utilized to fill gaps in knowledge for areas of the system where quantitative data does not yet exist or are hard to quantify. Therefore, the objective of this study was to identify quantifiable data about the current state of the factors that drive AMR and the strengths and directions of relationships between

APA, Harvard, Vancouver, ISO, and other styles

29

Pappas, Kyrie Jean, Wouter Karthaus, Justin Laclair, Marco Russo, and Charles Sawyers. "Abstract 391: Identifying molecular drivers of olaparib resistance through genome-wide sgRNA screening in prostate organoids." Cancer Research 82, no. 12_Supplement (2022): 391. http://dx.doi.org/10.1158/1538-7445.am2022-391.

Full text

Abstract:

Abstract Cancers harboring bi-allelic loss of the breast cancer genes (BRCA1 and BRCA2) are sensitive to poly(ADP-ribose) polymerase inhibitors (PARPi), which are clinically approved in breast, ovarian, and more recently prostate cancer. Genetic alteration of BRCA2 is frequent in metastatic castration-resistant prostate cancer (mCRPC), and confers sensitivity to the PARPi olaparib; however, resistance is anticipated. mCRPC has a unique genetic landscape, and is likely to present different mechanisms of resistance compared to breast and ovarian cancer because loss of BRCA2 in prostate cancer oc

APA, Harvard, Vancouver, ISO, and other styles

30

Lehmann, Rebecca, Joshua Zhu, Chelsea Mayoh, Maria Tsoli, Benjamin Rayner, and David Ziegler. "DDDR-30. IDENTIFICATION OF DRIVERS OF RESISTANCE IN BRAFV600E PEDIATRIC HIGH-GRADE GLIOMA AND NOVEL THERAPEUTIC TARGETS." Neuro-Oncology 25, Supplement_5 (2023): v112. http://dx.doi.org/10.1093/neuonc/noad179.0423.

Full text

Abstract:

Abstract The BRAFV600E mutation has recently been discovered as a driver mutation in a subset of pediatric high-grade gliomas (pHGG), with tumors driven by this mutation responding to targeted BRAF and MEK inhibitors. Unfortunately, resistance inevitability develops, resulting in disease progression. There is currently limited understanding of the mechanisms underlying drug resistance in BRAFV600E pHGG, and no effective counter-therapies exist. This study aimed to identify driver pathways of resistance in BRAFV600E pHGG and subsequently novel therapeutic targets. BRAF inhibitor-resistant, MEK

APA, Harvard, Vancouver, ISO, and other styles

31

Graham, Madeline E., Brenda A. Wilson, Davendra Ramkumar, Holly Rosencranz, and Japhia Ramkumar. "Unseen Drivers of Antimicrobial Resistance: The Role of Industrial Agriculture and Climate Change in This Global Health Crisis." Challenges 16, no. 2 (2025): 22. https://doi.org/10.3390/challe16020022.

Full text

Abstract:

Antimicrobial resistance (AMR) is an urgent global health threat with many anthropogenic drivers outside of healthcare. The impacts of modern agriculture on human health are manifold, from the food systems and dietary patterns they support to the less apparent effects of environmental stresses and biodiversity loss in ecosystems. Intensive practices, such as chemical fertilizers, pesticides, and herbicides, induce abiotic stresses that deplete biodiversity and drive AMR in soil and aquatic microbiomes. The overuse of antibiotics in livestock production is another major driver of AMR. Changes i

APA, Harvard, Vancouver, ISO, and other styles

32

Vasconcellos, Diego Klee de, Marco Antonio Bottino, Renato Sussumu Nishioka, Luiz Felipe Valandro, and Elza Maria Valadares da Costa. "The influence of different screw tightening forces on the vertical misfit of implant-supported frameworks." Journal of Applied Oral Science 13, no. 2 (2005): 120–25. http://dx.doi.org/10.1590/s1678-77572005000200005.

Full text

Abstract:

OBJECTIVES: The present in vitro study was designed to compare the differences in the vertical misfit of implant-supported frameworks using three different forces for tightening the bridge locking screws: fastening by hand until first resistance, and using torque drivers with 10 and 20Ncm. METHODS: The investigation was conducted based on the results given by 9 six-unit nickel-chromium (2 abutments/ 4 pontics) screw-retained implant-supported frameworks. The structures were exposed to simulated porcelain firings. The marginal misfit measurements were made using a traveling measuring microscope

APA, Harvard, Vancouver, ISO, and other styles

33

Gomes, Ana. "AGE-INDUCED SYSTEMIC REPROGRAMMING DRIVES DRUG RESISTANCE IN LUNG CANCER." Innovation in Aging 7, Supplement_1 (2023): 139–40. http://dx.doi.org/10.1093/geroni/igad104.0457.

Full text

Abstract:

Abstract Lung cancer accounts for the largest number of cancer-associated deaths in the United States. While great strides have been made due to the introduction of immunotherapies and targeted therapies against oncogenic drivers, chemotherapies remain the standard of care for the majority of lung cancer patients. However, many patients do not respond to these treatments or relapse following an initial response. We postulate that part of the problem is the lack of consideration in preclinical research and clinical trials of the main driver of lung tumorigenesis, the aging process. Here, we sho

APA, Harvard, Vancouver, ISO, and other styles

34

Qian, Chen, Qian Yang, Mirja Rotinen, et al. "Abstract 4302: ONECUT2 activates diverse resistance drivers of androgen receptor-independent heterogeneity in prostate cancer." Cancer Research 84, no. 6_Supplement (2024): 4302. http://dx.doi.org/10.1158/1538-7445.am2024-4302.

Full text

Abstract:

Abstract Androgen receptor- (AR-) indifference is a mechanism of resistance to hormonal therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates resistance through multiple drivers associated with adenocarcinoma, stem-like and neuroendocrine (NE) variants. Direct OC2 targets include the glucocorticoid receptor (GR) and the NE splicing factor SRRM4, which are key drivers of lineage plasticity. Thus, OC2, despite its previously described NEPC driver function, can indirectly activate a portion of the AR cistrome through epigenetic activation of GR. Mechanisms by which OC2

APA, Harvard, Vancouver, ISO, and other styles

35

Pashmineh, S., and D. Killat. "High-voltage circuits for power management on 65 nm CMOS." Advances in Radio Science 13 (November 3, 2015): 109–20. http://dx.doi.org/10.5194/ars-13-109-2015.

Full text

Abstract:

Abstract. This paper presents two high-voltage circuits used in power management, a switching driver for buck converter with optimized on-resistance and a low dropout (LDO) voltage regulator with 2-stacked pMOS pass devices. The circuit design is based on stacked MOSFETs, thus the circuits are technology independent. High-voltage drivers with stacked devices suffer from slow switching characteristics. In this paper, a new concept to adjust gate voltages of stacked transistors is introduced for reduction of on-resistance. According to the theory, a circuit is proposed that drives 2 stacked tran

APA, Harvard, Vancouver, ISO, and other styles

36

Zabala, Guillermo A., Khonsavath Bellingham, Vayouly Vidhamaly, et al. "Substandard and falsified antibiotics: neglected drivers of antimicrobial resistance?" BMJ Global Health 7, no. 8 (2022): e008587. http://dx.doi.org/10.1136/bmjgh-2022-008587.

Full text

Abstract:

ObjectivesAntimicrobial resistance (AMR) is a significant global health threat with substandard and falsified (SF) antibiotics being neglected contributing factors. With their relationships poorly understood, more research is needed in order to determine how interventions to reduce SF antibiotics should be ranked as priorities in national AMR action plans. We assessed the evidence available on the global prevalence of SF antibiotics, examined the quality of the evidence and discussed public health impact.Materials/MethodsWe searched PubMed, Embase, Google and Google Scholar for publications on

APA, Harvard, Vancouver, ISO, and other styles

37

Laxminarayan, Ramanan, and Ranjit Roy Chaudhury. "Antibiotic Resistance in India: Drivers and Opportunities for Action." PLOS Medicine 13, no. 3 (2016): e1001974. http://dx.doi.org/10.1371/journal.pmed.1001974.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Pomoni, Maria. "Exploring Smart Tires as a Tool to Assist Safe Driving and Monitor Tire–Road Friction." Vehicles 4, no. 3 (2022): 744–65. http://dx.doi.org/10.3390/vehicles4030042.

Full text

Abstract:

Road surface friction, or in other words, a pavement’s skid resistance, is an essential attribute of highway safety, acting as a liaison between the infrastructure condition and the driver’s response to it through proper vehicle maneuvering. The present study reviews aspects related to the tire–road friction, including affecting factors, monitoring systems and related practices, and demonstrates the efficacy of using smart tires, or tires embedded with sensors, for the purpose of evaluating roadway friction levels in real-time while traveling. Such an approach is expected to assist drivers in

APA, Harvard, Vancouver, ISO, and other styles

39

Izumi, Hiroki, Shingo Matsumoto, Kazumi Nishino, et al. "A nation-wide genomic screening project for further development of targeted therapies in treatment-refractory non–small-cell lung cancer (LC-SCRUM-TRY)." Journal of Clinical Oncology 41, no. 16_suppl (2023): 9097. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.9097.

Full text

Abstract:

9097 Background: Targeted therapies based on oncogenic drivers demonstrate dramatic and durable response in patients with non-small cell lung cancer (NSCLC). However, acquired resistance inevitably develop by diverse genomic resistance mechanisms. Genotype-matched targeted therapies to overcome treatment-resistance have not been established, except osimertinib against EGFR T790M mutation. Methods: We established a nation-wide genomic screening project in treatment-resistant NSCLC (LC-SCRUM-TRY; UMIN000041957) in September 2020 to identify the genetic resistant alterations, and to promote clini

APA, Harvard, Vancouver, ISO, and other styles

40

Murdock, Courtney C., Lillian L. Moller-Jacobs, and Matthew B. Thomas. "Complex environmental drivers of immunity and resistance in malaria mosquitoes." Proceedings of the Royal Society B: Biological Sciences 280, no. 1770 (2013): 20132030. http://dx.doi.org/10.1098/rspb.2013.2030.

Full text

Abstract:

Considerable research effort has been directed at understanding the genetic and molecular basis of mosquito innate immune mechanisms. Whether environmental factors interact with these mechanisms to shape overall resistance remains largely unexplored. Here, we examine how changes in mean ambient temperature, diurnal temperature fluctuation and time of day of infection affected the immunity and resistance of Anopheles stephensi to infection with Escherichia coli . We used quantitative PCR to estimate the gene expression of three immune genes in response to challenge with heat-killed E. coli . We

APA, Harvard, Vancouver, ISO, and other styles

41

Li, Mei-Mei, Yi-Ti He, Jie-Kai Liang, Xin-Yuan Guan, Ning-Fang Ma, and Ming Liu. "Cancer stem cell-mediated therapeutic resistance in hepatocellular carcinoma." Hepatoma Research 8 (2022): 36. http://dx.doi.org/10.20517/2394-5079.2022.43.

Full text

Abstract:

Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resistance is largely attributed to tumor heterogeneity. Growing evidence indicates that cancer stem cells (CSCs) are the major source of tumor heterogeneity. Hence, uncovering the resistance mechanisms associated with CSC properties is essential for developing effective therapeutics. CSCs resemble embryonic stem cells. Embryonic development-related genes and signaling pathways are usually abnormally active and function as oncofetal drivers in HCC. Multiple strategies have been applied to identify o

APA, Harvard, Vancouver, ISO, and other styles

42

Orlova, N. V., A. Ya Starokozheva, and A. V. Timoshchenko. "Role of stress in development of cardiovascular pathology in extreme professions." Medical alphabet 2, no. 27 (2019): 42–44. http://dx.doi.org/10.33667/2078-5631-2019-2-27(402)-42-44.

Full text

Abstract:

Psychoemotional stress is a risk factor for cardiovascular diseases, including arterial hypertension and coronary heart disease. Neurohumoral mechanisms are involved in the development of hypertensive reactions to stress. The severity of stress reactions depends on the stress resistance of people. The study of stress resistance is carried out in industrial sectors associated with the impact of professional psycho-emotional stress. Studies in locomotive drivers reveal a high level of cardiovascular disease. Stress helps to reduce vitamin D. Vitamin D deficiency helps reduce stress resistance. S

APA, Harvard, Vancouver, ISO, and other styles

43

Shah, Rishi M., Can M. Ersahin, Jeffrey D. Mandell, Vincent L. Cannataro, and Jeffrey P. Townsend. "Abstract C015: Selective and pairwise epistatic effects of somatic mutations in KRAS wild-type pancreatic cancer." Cancer Research 84, no. 17_Supplement_2 (2024): C015. http://dx.doi.org/10.1158/1538-7445.pancreatic24-c015.

Full text

Abstract:

Abstract About 8 to 10% of all pancreatic adenocarcinomas (PAAD) do not possess canonical mutations in KRAS. A sizable proportion of these KRAS wild-type (WT) pancreatic cancers harbor mutations in alternative MAPK-pathway driver genes. These alternative MAPK-pathway genes represent a set of therapeutic targets that might be exploited to treat individuals in this PAAD subset. Previous studies have prioritized the mutational- target landscape of KRAS WT PAAD by ranking genes determined by significance thresholds to be drivers by the prevalence of their somatic mutations in tumors. These prevale

APA, Harvard, Vancouver, ISO, and other styles

44

Geesin, Beverly, and Simon Mollan. "Taxis for neoliberalism! Surveillance and resistance in post-industrial Philadelphia." Competition & Change 24, no. 2 (2019): 114–32. http://dx.doi.org/10.1177/1024529419833623.

Full text

Abstract:

As a consequence of neoliberalism, employment has become increasingly precarious and informal, sitting outside of traditional organizational contexts. There is a need to better understand how these structures emerge and, importantly, how workers can also adapt to challenge these shifts. This article is a study of a labour dispute between Philadelphia taxicab drivers and the governmental regulatory body. The dispute was centred around the implementation of surveillance technologies to regulate and control the industry and the drivers’ working practices which they considered to be de-professiona

APA, Harvard, Vancouver, ISO, and other styles

45

Muhammad, Rashda Bintang. "PERLINDUNGAN HUKUM TAKSI ONLINE DI IBUKOTA JAKARTA BERDASARKAN PERATURAN MENTERI PERHUBUNGAN REPUBLIK INDONESIA." Jurnal Pendidikan Sosiologi dan Humaniora 13, no. 2 (2022): 302. http://dx.doi.org/10.26418/j-psh.v13i2.55341.

Full text

Abstract:

Absence of requirement consideration and lacking implementation of guidelines with respect to online cabbies' privileges are the central matters of online cab drivers. This is the inspiration for the creator to investigate the arrangements of the Regulation of the Minister of Transport of the Republic of Indonesia No. 118 of 2018 on the execution of extraordinary vehicle for enlist. In view of the consequences of the creator's meeting, it tends to be seen that there are as yet many advantages that web-based cabbies have not gotten, for example, having a region that doesn't reach out past Jakar

APA, Harvard, Vancouver, ISO, and other styles

46

Jang, Hyun Ji, and Jong-Whi Park. "Microenvironmental Drivers of Glioma Progression." International Journal of Molecular Sciences 26, no. 5 (2025): 2108. https://doi.org/10.3390/ijms26052108.

Full text

Abstract:

Gliomas, particularly glioblastoma (GBM), are among the most challenging brain tumors due to their complex and dynamic tumor microenvironment (TME). The TME plays a pivotal role in tumor progression, immune evasion, and resistance to therapy through intricate interactions among glioma cells, immune components, neurons, astrocytes, the extracellular matrix, and the blood-brain barrier. Targeting the TME has demonstrated potential, with immunotherapies such as checkpoint inhibitors and neoadjuvant therapies enhancing immune responses. Nonetheless, overcoming the immunosuppressive landscape and m

APA, Harvard, Vancouver, ISO, and other styles

47

Boynton, Adam, Leslie Lupien, Rushil Kumbhani, et al. "MEDB-85. Transcriptional complexes as resistance drivers to BET inhibition." Neuro-Oncology 24, Supplement_1 (2022): i126. http://dx.doi.org/10.1093/neuonc/noac079.459.

Full text

Abstract:

Abstract BET-bromodomain inhibition (BETi) is a promising therapeutic strategy to target MYC-driven cancers, including Group 3 medulloblastoma, a deadly childhood brain tumor. We have shown that BET inhibitors exhibit preclinical efficacy against MYC¬-amplified medulloblastoma, providing motivation to evaluate this drug class in early phase clinical trials. However, our work has also found that MYC-amplified medulloblastoma cells can acquire resistance to BETi, suggesting that curative responses for this disease will require combination therapy. To guide the development of such combination the

APA, Harvard, Vancouver, ISO, and other styles

48

Chatterjee, Anuja, Maryam Modarai, Nichola R. Naylor, et al. "Quantifying drivers of antibiotic resistance in humans: a systematic review." Lancet Infectious Diseases 18, no. 12 (2018): e368-e378. http://dx.doi.org/10.1016/s1473-3099(18)30296-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Yadav, Saurabh, Jasneet Khalsa, Ishwarya Murali, et al. "Potential Drivers of Acquired Resistance to Idelalisib in CLL Patients." Blood 140, Supplement 1 (2022): 12373–74. http://dx.doi.org/10.1182/blood-2022-166648.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Morina, Joseph C., and Rima B. Franklin. "Drivers of Antibiotic Resistance Gene Abundance in an Urban River." Antibiotics 12, no. 8 (2023): 1270. http://dx.doi.org/10.3390/antibiotics12081270.

Full text

Abstract:

In this study, we sought to profile the abundances and drivers of antibiotic resistance genes in an urban river impacted by combined sewage overflow (CSO) events. Water samples were collected weekly during the summer for two years; then, quantitative PCR was applied to determine the abundance of resistance genes associated with tetracycline, quinolones, and β-lactam antibiotics. In addition to sampling a CSO-impacted site near the city center, we also sampled a less urban site ~12 km upstream with no proximal sewage inputs. The tetracycline genes tetO and tetW were rarely found upstream, but w

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!