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Journal articles on the topic 'Drosophila Hematopoiesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Lanot, René, Daniel Zachary, François Holder, and Marie Meister. "Postembryonic Hematopoiesis in Drosophila." Developmental Biology 230, no. 2 (2001): 243–57. http://dx.doi.org/10.1006/dbio.2000.0123.

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2

Lan, Wenwen, Sumin Liu, Long Zhao, and Ying Su. "Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View." International Journal of Molecular Sciences 21, no. 15 (2020): 5246. http://dx.doi.org/10.3390/ijms21155246.

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The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoie

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3

Remillieux-Leschelle, Nathalie, Pedro Santamaria, and Neel B. Randsholt. "Regulation of Larval Hematopoiesis in Drosophila melanogaster: A Role for the multi sex combs Gene." Genetics 162, no. 3 (2002): 1259–74. http://dx.doi.org/10.1093/genetics/162.3.1259.

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Abstract Drosophila larval hematopoietic organs produce circulating hemocytes that ensure the cellular host defense by recognizing and neutralizing non-self or noxious objects through phagocytosis or encapsulation and melanization. Hematopoietic lineage specification as well as blood cell proliferation and differentiation are tightly controlled. Mutations in genes that regulate lymph gland cell proliferation and hemocyte numbers in the body cavity cause hematopoietic organ overgrowth and hemocyte overproliferation. Occasionally, mutant hemocytes invade self-tissues, behaving like neoplastic ma

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4

Evans, Cory J., and Utpal Banerjee. "Transcriptional regulation of hematopoiesis in Drosophila." Blood Cells, Molecules, and Diseases 30, no. 2 (2003): 223–28. http://dx.doi.org/10.1016/s1079-9796(03)00028-7.

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5

Varga, Gergely I. B., Gábor Csordás, Gyöngyi Cinege, et al. "Headcase is a Repressor of Lamellocyte Fate in Drosophila melanogaster." Genes 10, no. 3 (2019): 173. http://dx.doi.org/10.3390/genes10030173.

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Due to the evolutionary conservation of the regulation of hematopoiesis, Drosophila provides an excellent model organism to study blood cell differentiation and hematopoietic stem cell (HSC) maintenance. The larvae of Drosophila melanogaster respond to immune induction with the production of special effector blood cells, the lamellocytes, which encapsulate and subsequently kill the invader. Lamellocytes differentiate as a result of a concerted action of all three hematopoietic compartments of the larva: the lymph gland, the circulating hemocytes, and the sessile tissue. Within the lymph gland,

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6

Owusus-Ansah, Edward, Tina Mukherjee, William Kim, and Utpal Banerjee. "Maintaining Stem Cell Fate During Drosophila Hematopoiesis." Free Radical Biology and Medicine 49 (January 2010): S7. http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.675.

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7

Lin, Xionghui, and Irene Söderhäll. "Crustacean hematopoiesis and the astakine cytokines." Blood 117, no. 24 (2011): 6417–24. http://dx.doi.org/10.1182/blood-2010-11-320614.

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Abstract Major contributions to research in hematopoiesis in invertebrate animals have come from studies in the fruit fly, Drosophila melanogaster, and the freshwater crayfish, Pacifastacus leniusculus. These animals lack oxygen-carrying erythrocytes and blood cells of the lymphoid lineage, which participate in adaptive immune defense, thus making them suitable model animals to study the regulation of blood cells of the innate immune system. This review presents an overview of crustacean blood cell formation, the role of these cells in innate immunity, and how their synthesis is regulated by t

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8

Lebestky, T. "A Serrate-expressing signaling center controls Drosophila hematopoiesis." Genes & Development 17, no. 3 (2003): 348–53. http://dx.doi.org/10.1101/gad.1052803.

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9

Ramond, Elodie, Bianca Petrignani, Jan Paul Dudzic, et al. "The adipokine NimrodB5 regulates peripheral hematopoiesis in Drosophila." FEBS Journal 287, no. 16 (2020): 3399–426. http://dx.doi.org/10.1111/febs.15237.

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10

Milton, Claire C., Felix A. Grusche, Joffrey L. Degoutin, et al. "The Hippo Pathway Regulates Hematopoiesis in Drosophila melanogaster." Current Biology 24, no. 22 (2014): 2673–80. http://dx.doi.org/10.1016/j.cub.2014.10.031.

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11

Milner, LA, R. Kopan, DI Martin, and ID Bernstein. "A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors." Blood 83, no. 8 (1994): 2057–62. http://dx.doi.org/10.1182/blood.v83.8.2057.2057.

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Abstract Members of the Notch gene family have been shown to mediate cell-fate decisions by multipotent precursors in a number of different systems. To determine whether members of this family might play a similar role in hematopoiesis, we asked if homologues of the Notch gene are expressed in human hematopoietic precursors. Using degenerate oligonucleotides corresponding to conserved amino acid sequences in known Notch homologues as primers for the polymerase chain reaction (PCR), we demonstrated that at least one Notch homologue is expressed in human bone marrow CD34+ cells, a population enr

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12

Milner, LA, R. Kopan, DI Martin, and ID Bernstein. "A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors." Blood 83, no. 8 (1994): 2057–62. http://dx.doi.org/10.1182/blood.v83.8.2057.bloodjournal8382057.

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Members of the Notch gene family have been shown to mediate cell-fate decisions by multipotent precursors in a number of different systems. To determine whether members of this family might play a similar role in hematopoiesis, we asked if homologues of the Notch gene are expressed in human hematopoietic precursors. Using degenerate oligonucleotides corresponding to conserved amino acid sequences in known Notch homologues as primers for the polymerase chain reaction (PCR), we demonstrated that at least one Notch homologue is expressed in human bone marrow CD34+ cells, a population enriched for

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13

Duvic, Bernard, Jules A. Hoffmann, Marie Meister, and Julien Royet. "Notch Signaling Controls Lineage Specification during Drosophila Larval Hematopoiesis." Current Biology 12, no. 22 (2002): 1923–27. http://dx.doi.org/10.1016/s0960-9822(02)01297-6.

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14

Evans, Cory J., Ting Liu, and Utpal Banerjee. "Drosophila hematopoiesis: Markers and methods for molecular genetic analysis." Methods 68, no. 1 (2014): 242–51. http://dx.doi.org/10.1016/j.ymeth.2014.02.038.

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15

Rehorn, K. P., H. Thelen, A. M. Michelson, and R. Reuter. "A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila." Development 122, no. 12 (1996): 4023–31. http://dx.doi.org/10.1242/dev.122.12.4023.

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In vertebrates, transcriptional regulators of the GATA family appear to have a conserved function in differentiation and organ development. GATA-1, −2 and −3 are required for different aspects of hematopoiesis, while GATA-4, −5 and −6 are expressed in various organs of endodermal origin, such as intestine and liver, and are implicated in endodermal differentiation. Here we report that the Drosophila gene serpent (srp) encodes the previously described GATA factor ABF. The multiple functions of srp in Drosophila suggest that it is an ortholog of the entire vertebrate Gata family. srp is required

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16

Jung, S. H. "The Drosophila lymph gland as a developmental model of hematopoiesis." Development 132, no. 11 (2005): 2521–33. http://dx.doi.org/10.1242/dev.01837.

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17

Khadilkar, Rohan J., and Guy Tanentzapf. "Septate junction components control Drosophila hematopoiesis through the Hippo pathway." Development 146, no. 7 (2019): dev166819. http://dx.doi.org/10.1242/dev.166819.

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18

Ramond, Elodie, Marie Meister, and Bruno Lemaitre. "From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle." Developmental Cell 33, no. 4 (2015): 367–68. http://dx.doi.org/10.1016/j.devcel.2015.05.002.

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19

Corsetti, Maria Teresa, and Franco Calabi. "Lineage- and Stage-Specific Expression of Runt Box Polypeptides in Primitive and Definitive Hematopoiesis." Blood 89, no. 7 (1997): 2359–68. http://dx.doi.org/10.1182/blood.v89.7.2359.

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Abstract Translocations involving the human CBFA2 locus have been associated with leukemia. This gene, originally named AML1, is a human homologue of the Drosophila gene runt that controls early events in fly embryogenesis. To clarify the role of mammalian runt products in normal and leukemic hematopoiesis, we have studied their pattern of expression in mouse hematopoietic tissues in the adult and during ontogeny using an anti-runt box antiserum. In the adult bone marrow, we found expression of runt polypeptides in differentiating myeloid cells and in B lymphocytes. Within the erythroid lineag

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20

Yu, Shichao, Fangzhou Luo, and Li Hua Jin. "The Drosophila lymph gland is an ideal model for studying hematopoiesis." Developmental & Comparative Immunology 83 (June 2018): 60–69. http://dx.doi.org/10.1016/j.dci.2017.11.017.

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21

Qiu, P., P. C. Pan, and S. Govind. "A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis." Development 125, no. 10 (1998): 1909–20. http://dx.doi.org/10.1242/dev.125.10.1909.

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In the Drosophila larva, blood cells or hemocytes are formed in the lymph gland. The major blood cell type, called plasmatocyte, is small, non-adhesive and phagocytic. Plasmatocytes differentiate into adhesive lamellocytes to form multilayered capsules around foreign substances or, in mutant melanotic tumor strains, around self tissue. Mutations in cactus or Toll, or constitutive expression of dorsal can induce lamellocyte differentiation and cause the formation of melanotic capsules. As maternally encoded proteins, Toll, Cactus and Dorsal, along with Tube and Pelle, participate in a common si

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22

Tokusumi, T., Y. Tokusumi, D. W. Hopkins, D. A. Shoue, L. Corona, and R. A. Schulz. "Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis." Development 138, no. 18 (2011): 3879–84. http://dx.doi.org/10.1242/dev.069336.

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23

Georgantas, Robert W., Richard Hildreth, Jonathan Alder, Carlo M. Croce, George A. Calin, and Curt I. Civin. "MicroRNA Expression and Regulation of Hematopoiesis in CD34+ Cells: A Bioinformatic Circuit Diagram of the Hematopoietic Differentiation Control." Blood 108, no. 11 (2006): 1334. http://dx.doi.org/10.1182/blood.v108.11.1334.1334.

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Abstract MicroRNAs (miRs) are a recently realized class of epigenetic elements which block translation of mRNA to protein. MicroRNAs have been shown to control cellular metabolism, apoptosis, differentiation and development in numerous organisms including drosophila, rat, mouse, and humans. Recently, miRs have been implicated in the control of hematopoiesis. Importantly, both aberrant expression and deletion of miRs are have been associated with the development of various cancers. In a previous study, we determined the gene expression profiles of HSC-enriched, HPC-enriched, and total CD34+ cel

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24

Shravage, B. V., J. H. Hill, C. M. Powers, L. Wu, and E. H. Baehrecke. "Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila." Journal of Cell Science 126, no. 6 (2013): e1-e1. http://dx.doi.org/10.1242/jcs.133165.

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25

Shravage, B. V., J. H. Hill, C. M. Powers, L. Wu, and E. H. Baehrecke. "Atg6 is required for multiple vesicle trafficking pathways and hematopoiesis in Drosophila." Development 140, no. 6 (2013): 1321–29. http://dx.doi.org/10.1242/dev.089490.

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26

Ferguson, Gabriel B., and Julian A. Martinez-Agosto. "Yorkie and Scalloped Signaling Regulates Notch-Dependent Lineage Specification during Drosophila Hematopoiesis." Current Biology 24, no. 22 (2014): 2665–72. http://dx.doi.org/10.1016/j.cub.2014.09.081.

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27

Ghosh, Saikat, Sudip Mandal, and Lolitika Mandal. "Detecting proliferation of adult hemocytes in Drosophila by BrdU incorporation and PH3 expression in response to bacterial infection." Wellcome Open Research 3 (August 15, 2018): 47. http://dx.doi.org/10.12688/wellcomeopenres.14560.2.

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Drosophila and mammalian hematopoiesis share several similarities that range from primitive and definitive phases of hematopoiesis to the battery of transcription factors and signaling molecules that execute this process. The similarities in blood cell development across these divergent taxa along with the rich genetic tools available in fruitfly makes it a popular invertebrate model to study blood cell development both during normal and aberrant scenarios. The larval system is the most extensively studied till date. Several studies have shown that these hemocytes just like mammalian counterpa

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28

Gao, Hongjuan, Xiaorong Wu, and Nancy Fossett. "Upregulation of the Drosophila Friend of GATA Gene u-shaped by JAK/STAT Signaling Maintains Lymph Gland Prohemocyte Potency." Molecular and Cellular Biology 29, no. 22 (2009): 6086–96. http://dx.doi.org/10.1128/mcb.00244-09.

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ABSTRACT Studies using Drosophila melanogaster have contributed significantly to our understanding of the interaction between stem cells and their protective microenvironments or stem cell niches. During lymph gland hematopoiesis, the Drosophila posterior signaling center functions as a stem cell niche to maintain prohemocyte multipotency through Hedgehog and JAK/STAT signaling. In this study, we provide evidence that the Friend of GATA protein U-shaped is an important regulator of lymph gland prohemocyte potency and differentiation. U-shaped expression was determined to be upregulated in thir

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29

Ghosh, Saikat, Sudip Mandal, and Lolitika Mandal. "Detecting proliferation of adult hemocytes in Drosophila by BrdU incorporation." Wellcome Open Research 3 (April 24, 2018): 47. http://dx.doi.org/10.12688/wellcomeopenres.14560.1.

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Drosophila and mammalian hematopoiesis share several similarities that ranges from phases to the battery of transcription factors and signaling molecules that execute this process. These resounding similarities along with the rich genetic tools available in fruitfly makes it a popular invertebrate model to study blood cell development both during normal and aberrant conditions. The larval system is the most extensively studied to date. Several studies have shown that these hemocytes just like mammalian counterpart proliferate and get routinely regenerated upon infection. However, employing the

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30

Waltzer, L. "Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis." EMBO Journal 22, no. 24 (2003): 6516–25. http://dx.doi.org/10.1093/emboj/cdg622.

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31

Vincent, A., and M. Crozatier. "Neither Too Much Nor Too Little: Reactive Oxygen Species Levels Regulate Drosophila Hematopoiesis." Journal of Molecular Cell Biology 2, no. 2 (2009): 74–75. http://dx.doi.org/10.1093/jmcb/mjp042.

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32

Han, Z. "Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis." Development 133, no. 6 (2006): 1175–82. http://dx.doi.org/10.1242/dev.02285.

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33

Evans, Cory J., John M. Olson, Bama Charan Mondal, et al. "A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience." G3 Genes|Genomes|Genetics 11, no. 1 (2021): 1–23. http://dx.doi.org/10.1093/g3journal/jkaa028.

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Abstract Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify genes important for hematopoiesis in Drosophila. This screen disrupted the function of approximately 3500 genes and identified 137 candidate genes for which loss of function leads to observable changes in the hematopoietic development. Targeting RNAi to maturing, progenitor, and regulatory cell types identified key subsets that either limit or pro

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34

Gobert, Vanessa, Dani Osman, Stéphanie Bras, et al. "A Genome-Wide RNA Interference Screen Identifies a Differential Role of the Mediator CDK8 Module Subunits for GATA/ RUNX-Activated Transcription in Drosophila." Molecular and Cellular Biology 30, no. 11 (2010): 2837–48. http://dx.doi.org/10.1128/mcb.01625-09.

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ABSTRACT Transcription factors of the RUNX and GATA families play key roles in the control of cell fate choice and differentiation, notably in the hematopoietic system. During Drosophila hematopoiesis, the RUNX factor Lozenge and the GATA factor Serpent cooperate to induce crystal cell differentiation. We used Serpent/Lozenge-activated transcription as a paradigm to identify modulators of GATA/RUNX activity by a genome-wide RNA interference screen in cultured Drosophila blood cells. Among the 129 factors identified, several belong to the Mediator complex. Mediator is organized in three modules

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35

Hess, Jay L., Benjamin D. Yu, Bin Li, Rob Hanson, and Stanley J. Korsmeyer. "Defects in Yolk Sac Hematopoiesis in Mll-Null Embryos." Blood 90, no. 5 (1997): 1799–806. http://dx.doi.org/10.1182/blood.v90.5.1799.

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Abstract Translocations involving the mixed lineage leukemia gene (MLL ), the human homolog of the Drosophila gene trithorax, are one of the most common genetic alterations in human acute leukemias. Each translocation involving MLL results in loss of one functional copy of MLL and the generation of a chimeric fusion protein with potential dominant negative or neomorphic activity. Mll is a positive regulator of Hox genes, which have been implicated in both axial skeleton patterning and hematopoietic development. Previous studies indicated that Hox gene expression is altered in Mll heterozygous

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36

Kramer, Joseph J., Svetlana Minakhina, Neil Campbell, et al. "Alternative Splicing of PDCD2 Regulates Hematopoietic Stem Cell Specification, and Drives Multilineage Leukemia Development." Blood 114, no. 22 (2009): 258. http://dx.doi.org/10.1182/blood.v114.22.258.258.

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Abstract Abstract 258 PDCD2 (Programmed cell death domain 2) is a highly conserved zinc finger MYND domain-containing nuclear protein expressed in a variety of tissues. Our group has demonstrated that in Drosophila, PDCD2 mutants display massive lymph gland hyperplasia phenotype suggestive of hematopoietic hyperproliferation concomitant with a block in differentiation. The human PDCD2 gene is located on chromosome 6q27 and encodes two alternative transcripts with multiple splice variants. We analyzed primary human leukemias and multiple tumor cell lines and detected a PDCD2 splice variant whos

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37

Milchanowski, Allison B., Amy L. Henkenius, Maya Narayanan, Volker Hartenstein, and Utpal Banerjee. "Identification and Characterization of Genes Involved in Embryonic Crystal Cell Formation During Drosophila Hematopoiesis." Genetics 168, no. 1 (2004): 325–39. http://dx.doi.org/10.1534/genetics.104.028639.

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38

Trébuchet, Guillaume, Pierre B. Cattenoz, János Zsámboki, et al. "The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate." Journal of Neuroscience 39, no. 2 (2018): 238–55. http://dx.doi.org/10.1523/jneurosci.1059-18.2018.

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39

Kulkarni, Vani, Rohan J. Khadilkar, Srivathsa M. S., and Maneesha S. Inamdar. "Asrij Maintains the Stem Cell Niche and Controls Differentiation during Drosophila Lymph Gland Hematopoiesis." PLoS ONE 6, no. 11 (2011): e27667. http://dx.doi.org/10.1371/journal.pone.0027667.

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40

Heuser, Michael, Damian B. Yap, Malina Leung, et al. "Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation." Blood 113, no. 7 (2009): 1432–43. http://dx.doi.org/10.1182/blood-2008-06-162263.

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Abstract MLL5 is a divergent member of the Drosophila Trithorax-related (SET) domain and plant homeodomain (PHD) domain-containing chromatin regulators that are involved in the regulation of transcriptional “memory” during differentiation. Human MLL5 is located on chromosome 7q22, which frequently is deleted in myeloid leukemias, suggesting a possible role in hemopoiesis. To address this question, we generated a loss-of-function allele (Mll5tm1Apa) in the murine Mll5 locus. Unlike other Mll genes, Mll5tm1Apa homozygous mice are viable but display defects in immunity and hematopoiesis. First, M

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41

Yagi, Hideshi, Kenji Deguchi, Atsufumi Aono, Yoshihiko Tani, Tadamitsu Kishimoto, and Toshihisa Komori. "Growth Disturbance in Fetal Liver Hematopoiesis of Mll-Mutant Mice." Blood 92, no. 1 (1998): 108–17. http://dx.doi.org/10.1182/blood.v92.1.108.413k11_108_117.

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The MLL (ALL-1, HRX) gene is frequently involved in chromosomal translocations in acute leukemia and has homology with Drosophila trithorax, which controls homeobox gene expression and embryogenesis. To elucidate the function of Mll, we generated mice with a mutated Mll locus. Mice with a homozygous mutation were embryonic lethal and died at embryonic day 11.5 to 14.5, showing edematous bodies and petechiae. Histological examination revealed that hematopoietic cells were decreased in the liver of homozygous embryos, although they were composed of erythroid, myeloid, monocytic, and megakaryocyt

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42

Ramroop, Johnny R., Mary Ellen Heavner, Zubaidul H. Razzak, and Shubha Govind. "A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host’s blood cells." PLOS Pathogens 17, no. 5 (2021): e1009615. http://dx.doi.org/10.1371/journal.ppat.1009615.

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The wasps Leptopilina heterotoma parasitize and ingest their Drosophila hosts. They produce extracellular vesicles (EVs) in the venom that are packed with proteins, some of which perform immune suppressive functions. EV interactions with blood cells of host larvae are linked to hematopoietic depletion, immune suppression, and parasite success. But how EVs disperse within the host, enter and kill hematopoietic cells is not well understood. Using an antibody marker for L. heterotoma EVs, we show that these parasite-derived structures are readily distributed within the hosts’ hemolymphatic system

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43

Ohta, Hideaki, Akihisa Sawada, Ji Yoo Kim, et al. "Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells." Journal of Experimental Medicine 195, no. 6 (2002): 759–70. http://dx.doi.org/10.1084/jem.20011911.

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The rae28 gene (rae28), also designated as mph1, is a mammalian ortholog of the Drosophila polyhomeotic gene, a member of Polycomb group genes (PcG). rae28 constitutes PcG complex 1 for maintaining transcriptional states which have been once initiated, presumably through modulation of the chromatin structure. Hematopoietic activity was impaired in the fetal liver of rae28-deficient animals (rae28−/−), as demonstrated by progressive reduction of hematopoietic progenitors of multilineages and poor expansion of colony forming units in spleen (CFU-S12) during embryonic development. An in vitro lon

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44

Perna, Fabiana, Nadia Gurvich, Ruben Hoya-Arias, et al. "Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q− polycythemia vera." Blood 116, no. 15 (2010): 2812–21. http://dx.doi.org/10.1182/blood-2010-02-270611.

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Abstract L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia. L3MBTL1 is expressed within hematopoietic CD34+ cells; thus, it may contribute to the pathogenesis of these disorders. To define its role in hematopoiesis, we knocked down L3MBTL1 expression in primary hematopoietic stem/progenitor (ie, CD34+) cells isolated from human cord blood (using short hairpin RNAs) an

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45

Bruno, Edward, Stephen K. Horrigan, David Van Den Berg та ін. "The Smad5 Gene Is Involved in the Intracellular Signaling Pathways That Mediate the Inhibitory Effects of Transforming Growth Factor-β on Human Hematopoiesis". Blood 91, № 6 (1998): 1917–23. http://dx.doi.org/10.1182/blood.v91.6.1917.

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Abstract Signals from transforming growth factor-β (TGF-β), a bifunctional regulator of the proliferation of hematopoietic progenitor cells, have been recently shown to be transduced by five novel human genes related to a Drosophila gene termed MAD (mothers against the decapentaplegic gene). We showed by reverse transcriptase polymerase chain reaction that the RNA from one homologue gene, Smad5, was present in the immortalized myeloid leukemia cell lines, KG1 and HL60, in bone marrow mononuclear and polymorphonuclear cells, as well as in purified CD34+ bone marrow cells. Therefore, we studied

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46

Bruno, Edward, Stephen K. Horrigan, David Van Den Berg та ін. "The Smad5 Gene Is Involved in the Intracellular Signaling Pathways That Mediate the Inhibitory Effects of Transforming Growth Factor-β on Human Hematopoiesis". Blood 91, № 6 (1998): 1917–23. http://dx.doi.org/10.1182/blood.v91.6.1917.1917_1917_1923.

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Signals from transforming growth factor-β (TGF-β), a bifunctional regulator of the proliferation of hematopoietic progenitor cells, have been recently shown to be transduced by five novel human genes related to a Drosophila gene termed MAD (mothers against the decapentaplegic gene). We showed by reverse transcriptase polymerase chain reaction that the RNA from one homologue gene, Smad5, was present in the immortalized myeloid leukemia cell lines, KG1 and HL60, in bone marrow mononuclear and polymorphonuclear cells, as well as in purified CD34+ bone marrow cells. Therefore, we studied the role

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47

Fisher, Cynthia L., Nicolas Pineault, Christy Brookes, et al. "Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia." Blood 115, no. 1 (2010): 38–46. http://dx.doi.org/10.1182/blood-2009-07-230698.

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Abstract The Additional sex combs like 1 (Asxl1) gene is 1 of 3 mammalian homologs of the Additional sex combs (Asx) gene of Drosophila. Asx is unusual because it is required to maintain both activation and silencing of Hox genes in flies and mice. Asxl proteins are characterized by an amino terminal homology domain, by interaction domains for nuclear receptors, and by a C-terminal plant homeodomain protein-protein interaction domain. A recent study of patients with myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) revealed a high incidence of truncation mutations that

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Han, Z. "Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis." Development 132, no. 15 (2005): 3525–36. http://dx.doi.org/10.1242/dev.01899.

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Sinha, Saloni, Arindam Ray, Lakshman Abhilash, et al. "Proteomics of Asrij Perturbation in Drosophila Lymph Glands for Identification of New Regulators of Hematopoiesis." Molecular & Cellular Proteomics 18, no. 6 (2019): 1171–82. http://dx.doi.org/10.1074/mcp.ra119.001299.

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Grigorian, Melina, Lolitika Mandal, and Volker Hartenstein. "Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland." Development Genes and Evolution 221, no. 3 (2011): 121–31. http://dx.doi.org/10.1007/s00427-011-0364-6.

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