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Journal articles on the topic 'Drosophila melanogaster dopamine transporter'

Author: Grafiati

Published: 6 September 2023

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1

Pugh, Ciara Frances, Brian Thomas DeVree, Solveig Gaarde Schmidt, and Claus Juul Loland. "Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster." Cells 11, no. 23 (2022): 3811. http://dx.doi.org/10.3390/cells11233811.

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The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission. Our current structural understanding of DAT is derived from the resolutions of DAT from Drosophila melanogaster (dDAT). Despite extensive structural studies of purified dDAT in complex with a variety of antidepressants, psychostimulants and its endogenous substrate, dopamine, the molecular pharmacology of purified, full length dDAT is yet to be elucidated. In this study

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2

Góral, Izabella, Kamil Łątka, and Marek Bajda. "Structure Modeling of the Norepinephrine Transporter." Biomolecules 10, no. 1 (2020): 102. http://dx.doi.org/10.3390/biom10010102.

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The norepinephrine transporter (NET) is one of the monoamine transporters. Its X-ray crystal structure has not been obtained yet. Inhibitors of human NET (hNET) play a major role in the treatment of many central and peripheral nervous system diseases. In this study, we focused on the spatial structure of a NET constructed by homology modeling on Drosophila melanogaster dopamine transporter templates. We further examined molecular construction of primary binding pocket (S1) together with secondary binding site (S2) and extracellular loop 4 (EL4). The next stage involved docking of transporter i

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3

Filošević Vujnović, Ana, Katarina Jović, Emanuel Pištan, and Rozi Andretić Waldowski. "Influence of Dopamine on Fluorescent Advanced Glycation End Products Formation Using Drosophila melanogaster." Biomolecules 11, no. 3 (2021): 453. http://dx.doi.org/10.3390/biom11030453.

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Non-enzymatic glycation and covalent modification of proteins leads to Advanced Glycation End products (AGEs). AGEs are biomarkers of aging and neurodegenerative disease, and can be induced by impaired neuronal signaling. The objective of this study was to investigate if manipulation of dopamine (DA) in vitro using the model protein, bovine serum albumin (BSA), and in vivo using the model organism Drosophila melanogaster, influences fluorescent AGEs (fAGEs) formation as an indicator of dopamine-induced oxidation events. DA inhibited fAGEs-BSA synthesis in vitro, suggesting an anti-oxidative ef

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4

Shin, Mimi, and B. Jill Venton. "(Digital Presentation) In Vivo Electrochemical Measurement of Dopamine in Adult Drosophila Mushroom Body." ECS Meeting Abstracts MA2022-01, no. 53 (2022): 2197. http://dx.doi.org/10.1149/ma2022-01532197mtgabs.

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Dopamine is a neuromodulator that is secreted to the synapse to relay chemical signals to target neurons. Abnormal levels of dopamine release leads to various neurodegenerative diseases. Therefore, measuring dopamine is essential to understand how dopamine is regulated under normal and pathological conditions. Drosophila melanogaster, the fruit fly, is an ideal model system for studying fundamental neurological processes and diseases because of the availability of sophisticated genetic tools and well conserved neurological processes between mammals and flies. Majority of neuroscience studies i

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Myers, Jennifer L., Maria Porter, Nicholas Narwold, Krishna Bhat, Brigitte Dauwalder, and Gregg Roman. "Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis." International Journal of Molecular Sciences 22, no. 23 (2021): 12967. http://dx.doi.org/10.3390/ijms222312967.

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Drosophila’s white gene encodes an ATP-binding cassette G-subfamily (ABCG) half-transporter. White is closely related to mammalian ABCG family members that function in cholesterol efflux. Mutants of white have several behavioral phenotypes that are independent of visual defects. This study characterizes a novel defect of white mutants in the acquisition of olfactory memory using the aversive olfactory conditioning paradigm. The w1118 mutants learned slower than wildtype controls, yet with additional training, they reached wildtype levels of performance. The w1118 learning phenotype is also fou

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6

Hamilton, P. J., N. G. Campbell, S. Sharma, et al. "Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene." Molecular Psychiatry 18, no. 12 (2013): 1235. http://dx.doi.org/10.1038/mp.2013.157.

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7

Makos, Monique A., Kyung-An Han, Michael L. Heien, and Andrew G. Ewing. "Using in Vivo Electrochemistry To Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter." ACS Chemical Neuroscience 1, no. 1 (2009): 74–83. http://dx.doi.org/10.1021/cn900017w.

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8

Neckameyer, Wendi S., Stacey Woodrome, Bridgette Holt, and Adam Mayer. "Dopamine and senescence in Drosophila melanogaster☆." Neurobiology of Aging 21, no. 1 (2000): 145–52. http://dx.doi.org/10.1016/s0197-4580(99)00109-8.

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9

Giang, Thomas, Steffen Rauchfuss, Maite Ogueta, and Henrike Scholz. "The Serotonin Transporter Expression in Drosophila melanogaster." Journal of Neurogenetics 25, no. 1-2 (2011): 17–26. http://dx.doi.org/10.3109/01677063.2011.553002.

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10

Southon, A., A. Farlow, M. Norgate, R. Burke, and J. Camakaris. "Malvolio is a copper transporter in Drosophila melanogaster." Journal of Experimental Biology 211, no. 5 (2008): 709–16. http://dx.doi.org/10.1242/jeb.014159.

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11

Vickrey, Trisha L., Ning Xiao, and B. Jill Venton. "Kinetics of the Dopamine Transporter in Drosophila Larva." ACS Chemical Neuroscience 4, no. 5 (2013): 832–37. http://dx.doi.org/10.1021/cn400019q.

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12

Andretic, R., and J. Hirsh. "Circadian modulation of dopamine receptor responsiveness in Drosophila melanogaster." Proceedings of the National Academy of Sciences 97, no. 4 (2000): 1873–78. http://dx.doi.org/10.1073/pnas.97.4.1873.

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13

Pham, Tuan L. A., Tran Duy Binh, Guanchen Liu, et al. "Role of Serotonin Transporter in Eye Development of Drosophila melanogaster." International Journal of Molecular Sciences 21, no. 11 (2020): 4086. http://dx.doi.org/10.3390/ijms21114086.

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Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in Drosophila melanogaster. We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. Furthermore, the knockdown of SerT in the eye disc suppressed the activation of Akt, and the introduction of PI3K effectively rescued this phenotype. These results sugge

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14

Ueno, Taro, Shoen Kume, and Kazuhiko Kume. "Dopamine controls temperature preferences and energy homeostasis in Drosophila melanogaster." Neuroscience Research 68 (January 2010): e399. http://dx.doi.org/10.1016/j.neures.2010.07.1772.

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15

Martínez-Ramírez, Amparo C., Juan Ferré, and Francisco J. Silva. "Catecholamines in drosophila melanogaster: DOPA and dopamine accumulation during development." Insect Biochemistry and Molecular Biology 22, no. 5 (1992): 491–94. http://dx.doi.org/10.1016/0965-1748(92)90145-5.

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16

Ueno, Taro, Jun Tomita, Shoen Kume, and Kazuhiko Kume. "Dopamine Modulates Metabolic Rate and Temperature Sensitivity in Drosophila melanogaster." PLoS ONE 7, no. 2 (2012): e31513. http://dx.doi.org/10.1371/journal.pone.0031513.

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17

Fernandez, Robert W., Adesanya A. Akinleye, Marat Nurilov, et al. "Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant." Biology Letters 13, no. 8 (2017): 20170369. http://dx.doi.org/10.1098/rsbl.2017.0369.

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Appropriate response to others is necessary for social interactions. Yet little is known about how neurotransmitters regulate attractive and repulsive social cues. Using genetic and pharmacological manipulations in Drosophila melanogaster , we show that dopamine is contributing the response to others in a social group, specifically, social spacing, but not the avoidance of odours released by stressed flies (dSO). Interestingly, this dopamine-mediated behaviour is prominent only in the day-time, and its effect varies depending on tissue, sex and type of manipulation. Furthermore, alteration of

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18

Chatterjee, Nabanita, Janet Rollina, and Christopher Bazinet. "Testes specific neurotransmitter transporter essential for male fertility in Drosophila melanogaster." Developmental Biology 344, no. 1 (2010): 513. http://dx.doi.org/10.1016/j.ydbio.2010.05.361.

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19

MacIver, B., A. McCahill, S. Pathirana, K. Leaper, and M. Bownes. "A putative sodium-dependent inorganic phosphate co-transporter from Drosophila melanogaster." Development Genes and Evolution 210, no. 4 (2000): 207–11. http://dx.doi.org/10.1007/s004270050305.

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20

Pyakurel, Poojan, Mimi Shin, and B. Jill Venton. "Nicotinic acetylcholine receptor (nAChR) mediated dopamine release in larval Drosophila melanogaster." Neurochemistry International 114 (March 2018): 33–41. http://dx.doi.org/10.1016/j.neuint.2017.12.012.

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21

SOUTHON, Adam, Richard BURKE, Melanie NORGATE, Philip BATTERHAM, and James CAMAKARIS. "Copper homoeostasis in Drosophila melanogaster S2 cells." Biochemical Journal 383, no. 2 (2004): 303–9. http://dx.doi.org/10.1042/bj20040745.

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Copper homoeostasis was investigated in the Drosophila melanogaster S2 cell line to develop an insect model for the study of copper regulation. Real-time PCR studies have demonstrated expression in S2 cells of putative orthologues of human Cu regulatory genes involved in the uptake, transport, sequestration and efflux of Cu. Drosophila orthologues of the mammalian Cu chaperones, ATOX1 (a human orthologue of yeast ATX1), CCS (copper chaperone for superoxide dismutase), COX17 (a human orthologue of yeast COX17), and SCO1 and SCO2, did not significantly respond transcriptionally to increased Cu l

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22

Pörzgen, Peter, Sang Ki Park, Jay Hirsh, Mark S. Sonders, and Susan G. Amara. "The Antidepressant-Sensitive Dopamine Transporter inDrosophila melanogaster: A Primordial Carrier for Catecholamines." Molecular Pharmacology 59, no. 1 (2001): 83–95. http://dx.doi.org/10.1124/mol.59.1.83.

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23

Santoso, Clarissa S., Tracy L. Meehan, Jeanne S. Peterson, Tiara M. Cedano, Christopher V. Turlo, and Kimberly McCall. "The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary." G3: Genes|Genomes|Genetics 8, no. 3 (2018): 833–43. http://dx.doi.org/10.1534/g3.117.300427.

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24

Jang, Cholsoon, Gina Lee, and Jongkyeong Chung. "LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster." Journal of Cell Biology 183, no. 1 (2008): 11–17. http://dx.doi.org/10.1083/jcb.200807052.

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Silnoon (Sln) is a monocarboxylate transporter (MCT) that mediates active transport of metabolic monocarboxylates such as butyrate and lactate. Here, we identify Sln as a novel LKB1-interacting protein using Drosophila melanogaster genetic modifier screening. Sln expression does not affect cell cycle progression or cell size but specifically enhances LKB1-dependent apoptosis and tissue size reduction. Conversely, down-regulation of Sln suppresses LKB1-dependent apoptosis, implicating Sln as a downstream mediator of LKB1. The kinase activity of LKB1 induces apical trafficking of Sln in polarize

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25

Neckameyer, Wendi S. "Dopamine and Mushroom Bodies in Drosophila: Experience-Dependent and -Independent Aspects of Sexual Behavior." Learning & Memory 5, no. 1 (1998): 157–65. http://dx.doi.org/10.1101/lm.5.1.157.

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Depletion of dopamine in Drosophila melanogaster adult males, accomplished through systemic introduction of the tyrosine hydroxylase inhibitor 3-iodo-tyrosine, severely impaired the ability of these flies to modify their courtship responses to immature males. Mature males, when first exposed to immature males, will perform courtship rituals; the intensity and duration of this behavior rapidly diminshes with time. Dopamine is also required for normal female sexual receptivity; dopamine-depleted females show increased latency to copulation. One kilobase of 5′ upstream information from theDrosoph

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26

Needham, Andrew J., Monica Kibart, Howard Crossley, Philip W. Ingham, and Simon J. Foster. "Drosophila melanogaster as a model host for Staphylococcus aureus infection." Microbiology 150, no. 7 (2004): 2347–55. http://dx.doi.org/10.1099/mic.0.27116-0.

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Staphylococcus aureus is an important pathogen of humans, causing a range of superficial and potentially life-threatening diseases. Infection of the fruit fly Drosophila melanogaster with S. aureus results in systemic infection followed by death. Screening of defined S. aureus mutants for components important in pathogenesis identified perR and pheP, with fly death up to threefold slower after infection with the respective mutants compared to the wild-type. Infection of D. melanogaster with reporter gene fusion strains demonstrated the in vivo expression levels of the accessory gene regulator,

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27

van der Voet, M., B. Harich, B. Franke, and A. Schenck. "ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila." Molecular Psychiatry 21, no. 4 (2015): 565–73. http://dx.doi.org/10.1038/mp.2015.55.

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28

CARRILLO, ROLAND, and GREG GIBSON. "Unusual genetic architecture of natural variation affecting drug resistance in Drosophila melanogaster." Genetical Research 80, no. 3 (2002): 205–13. http://dx.doi.org/10.1017/s0016672302005888.

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Naturally occurring genetic variation was quantified for survival time of adult Drosophila melanogaster exposed to chronic ingestion of the drugs nicotine, caffeine, dopamine, tyramine and octopamine. Responses to nicotine, tyramine and octopamine were genetically correlated in both sexes, whereas caffeine response correlated with starvation resistance. However, there is also genetic variation that is specific for each of the drugs. Females tended to be more resistant than males to nicotine and caffeine but sex-by-genotype interactions were also seen for these drugs and for the response to dop

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29

Akiba, Masumi, Kentaro Sugimoto, Risa Aoki, et al. "Dopamine modulates the optomotor response to unreliable visual stimuli in Drosophila melanogaster." European Journal of Neuroscience 51, no. 3 (2020): 822–39. http://dx.doi.org/10.1111/ejn.14648.

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30

Wicker-Thomas, Claude, and Mickael Hamann. "Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster." Journal of Insect Physiology 54, no. 10-11 (2008): 1423–31. http://dx.doi.org/10.1016/j.jinsphys.2008.08.005.

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31

Marican, Charlotte, Line Duportets, Serge Birman, and Jean Marc Jallon. "Female-specific regulation of cuticular hydrocarbon biosynthesis by dopamine in Drosophila melanogaster." Insect Biochemistry and Molecular Biology 34, no. 8 (2004): 823–30. http://dx.doi.org/10.1016/j.ibmb.2004.05.002.

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32

Lühn, Kerstin, Anna Laskowska, Jan Pielage, et al. "Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster." Experimental Cell Research 301, no. 2 (2004): 242–50. http://dx.doi.org/10.1016/j.yexcr.2004.08.043.

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33

Vozza, Angelo, Francesco De Leonardis, Eleonora Paradies, et al. "Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1858, no. 2 (2017): 137–46. http://dx.doi.org/10.1016/j.bbabio.2016.11.006.

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34

Dhanraj, Vijayraja, Tamilarasan Manivasagam, and Jeyaprakash Karuppaiah. "MYRICETIN ISOLATED FROM TURBINARIA ORNATA AMELIORATES ROTENONE INDUCED PARKINSONISM IN DROSOPHILA MELANOGASTER." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 39. http://dx.doi.org/10.22159/ijpps.2017v9i11.19931.

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Objective: Parkinson’s disease (PD) is a neurodegenerative disorder which affects the elderly population. Free radicals overproduction, oxidative stress, apoptosis, inflammation and abnormalities in mitochondria are critical mediators of the neuronal degeneration. In the present study neuroprotective activity of myricetin, a flavonoid isolated from brown seaweed Turbinaria ornata have been investigated in rotenone induced experimental PD models of Drosophila melanogaster.Methods: Male fruit flies (Drosophila melanogaster) were fed with an effective dose of 0.1% myricetin three hours before to

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35

KUME, Kazuhiko. "A Drosophila dopamine transporter mutant, fumin (fmn), is defective in arousal regulation." Sleep and Biological Rhythms 4, no. 3 (2006): 263–73. http://dx.doi.org/10.1111/j.1479-8425.2006.00225.x.

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36

INOUE, Katsuhisa, You-Jun FEI, Wei HUANG, Lina ZHUANG, Zhong CHEN, and Vadivel GANAPATHY. "Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates." Biochemical Journal 367, no. 2 (2002): 313–19. http://dx.doi.org/10.1042/bj20021132.

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Indy is a gene in Drosophila melanogaster which, when made dysfunctional, leads to an extension of the average adult life span of the organism. The present study was undertaken to clone the Indy gene-product and to establish its functional identity. We isolated a full-length Indy cDNA from a D. melanogaster cDNA library. The cDNA codes for a protein of 572 amino acids [(Drosophila Indy (drIndy)]. In its amino acid sequence, drIndy exhibits comparable similarity to the two known Na+-coupled dicarboxylate transporters in mammals; namely, NaDC1 (35% identity) and NaDC3 (34% identity). We elucidat

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37

Knapp, Elizabeth M., Andrea Kaiser, Rebecca C. Arnold, et al. "Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors." PLOS Genetics 18, no. 11 (2022): e1010289. http://dx.doi.org/10.1371/journal.pgen.1010289.

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The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. The mechanisms by which inhibition of SERT activity influences behavior are poorly understood. To address this question in the model organism Drosophila melanogaster, we developed new loss of function mutations in Drosophila SERT (dSERT). Previous studies in both flies and mammals have implicated serotonin as an important neuromodulator of sleep, and our newly generated dSERT mutants show an increase in total sleep and altered sleep architecture that is mi

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38

Baier, Andrea, Britta Wittek, and Björn Brembs. "Drosophilaas a new model organism for the neurobiology of aggression?" Journal of Experimental Biology 205, no. 9 (2002): 1233–40. http://dx.doi.org/10.1242/jeb.205.9.1233.

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SUMMARYWe report here the effects of several neurobiological determinants on aggressive behaviour in the fruitfly Drosophila melanogaster. This study combines behavioural, transgenic, genetic and pharmacological techniques that are well established in the fruitfly, in the novel context of the neurobiology of aggression. We find that octopamine, dopamine and a region in the Drosophila brain called the mushroom bodies, all profoundly influence the expression of aggressive behaviour. Serotonin had no effect. We conclude that Drosophila, with its advanced set of molecular tools and its behavioural

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39

Braco, Jason T., Jonathan M. Nelson, Cecil J. Saunders, and Erik C. Johnson. "Modulation of Metabolic Hormone Signaling via a Circadian Hormone and Biogenic Amine in Drosophila melanogaster." International Journal of Molecular Sciences 23, no. 8 (2022): 4266. http://dx.doi.org/10.3390/ijms23084266.

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In insects, adipokinetic hormone is the primary hormone responsible for the mobilization of stored energy. While a growing body of evidence has solidified the role of adipokinetic hormone (AKH) in modulating the physiological and behavioral responses to metabolic stress, little is known about the upstream endocrine circuit that directly regulates AKH release. We evaluated the AKH-producing cell (APC) transcriptome to identify potential regulatory elements controlling APC activity and found that a number of receptors showed consistent expression levels, including all known dopamine receptors an

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40

Van Swinderen, Bruno, and Rozi Andretic. "Dopamine in Drosophila : setting arousal thresholds in a miniature brain." Proceedings of the Royal Society B: Biological Sciences 278, no. 1707 (2011): 906–13. http://dx.doi.org/10.1098/rspb.2010.2564.

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In mammals, the neurotransmitter dopamine (DA) modulates a variety of behaviours, although DA function is mostly associated with motor control and reward. In insects such as the fruitfly, Drosophila melanogaster , DA also modulates a wide array of behaviours, ranging from sleep and locomotion to courtship and learning. How can a single molecule play so many different roles? Adaptive changes within the DA system, anatomical specificity of action and effects on a variety of behaviours highlight the remarkable versatility of this neurotransmitter. Recent genetic and pharmacological manipulations

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White, Daniel, Raquel P. de Sousa Abreu, Andrew Blake, et al. "Deficits in the vesicular acetylcholine transporter alter lifespan and behavior in adult Drosophila melanogaster." Neurochemistry International 137 (July 2020): 104744. http://dx.doi.org/10.1016/j.neuint.2020.104744.

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42

Roman, Gregg, Victoria Meller, Kwok Hang Wu, and Ronald L. Davis. "The opt1 gene ofDrosophila melanogaster encodes a proton-dependent dipeptide transporter." American Journal of Physiology-Cell Physiology 275, no. 3 (1998): C857—C869. http://dx.doi.org/10.1152/ajpcell.1998.275.3.c857.

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We have cloned and characterized the opt1 gene of Drosophila melanogaster. This gene encodes a protein with significant similarity to the PTR family of oligopeptide transporters. The OPT1 protein is localized to the apical epithelial membrane domains of the midgut, rectum, and female reproductive tract. The opt1 message is maternally loaded into developing oocytes, and OPT1 is found in the α-yolk spheres of the developing embryo. It is also found throughout the neuropil of the central nervous system, with elevated expression within the α- and β-lobes of the mushroom bodies. Transport activity

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43

Penmatsa, Aravind, Kevin H. Wang, and Eric Gouaux. "X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine." Nature Structural & Molecular Biology 22, no. 6 (2015): 506–8. http://dx.doi.org/10.1038/nsmb.3029.

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44

Jakšić, Ana Marija, Julia Karner, Viola Nolte, et al. "Neuronal Function and Dopamine Signaling Evolve at High Temperature in Drosophila." Molecular Biology and Evolution 37, no. 9 (2020): 2630–40. http://dx.doi.org/10.1093/molbev/msaa116.

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Abstract Neuronal activity is temperature sensitive and affects behavioral traits important for individual fitness, such as locomotion and courtship. Yet, we do not know enough about the evolutionary response of neuronal phenotypes in new temperature environments. Here, we use long-term experimental evolution of Drosophila simulans populations exposed to novel temperature regimes. Here, we demonstrate a direct relationship between thermal selective pressure and the evolution of neuronally expressed molecular and behavioral phenotypes. Several essential neuronal genes evolve lower expression at

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45

Budnik, Vivian, and Kalpana White. "Genetic dissection of dopamine and serotonin synthesis in the nervous system of Drosophila melanogaster." Journal of Neurogenetics 4, no. 1 (1987): 309–14. http://dx.doi.org/10.3109/01677068709102351.

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46

Rauschenbach, I. Yu, E. K. Karpova, A. A. Alekseev, N. V. Adonyeva, L. V. Shumnaya, and N. E. Gruntenko. "Interplay of insulin and dopamine signaling pathways in the control of Drosophila melanogaster fitness." Doklady Biochemistry and Biophysics 461, no. 1 (2015): 135–38. http://dx.doi.org/10.1134/s1607672915020179.

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47

Izoré, Thierry, Julien Tailhades, Mathias Henning Hansen, Joe A. Kaczmarski, Colin J. Jackson, and Max J. Cryle. "Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain." Proceedings of the National Academy of Sciences 116, no. 8 (2019): 2913–18. http://dx.doi.org/10.1073/pnas.1811194116.

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The protein Ebony from Drosophila melanogaster plays a central role in the regulation of histamine and dopamine in various tissues through condensation of these amines with β-alanine. Ebony is a rare example of a nonribosomal peptide synthetase (NRPS) from a higher eukaryote and contains a C-terminal sequence that does not correspond to any previously characterized NRPS domain. We have structurally characterized this C-terminal domain and have discovered that it adopts the aryl-alkylamine-N-acetyl transferase (AANAT) fold, which is unprecedented in NRPS biology. Through analysis of ligand-boun

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48

Demchyshyn, L. L., Z. B. Pristupa, K. S. Sugamori, et al. "Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster." Proceedings of the National Academy of Sciences 91, no. 11 (1994): 5158–62. http://dx.doi.org/10.1073/pnas.91.11.5158.

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49

Zhang, Jiajun, Lucie Lentz, Jens Goldammer, Jessica Iliescu, Jun Tanimura, and Thomas Dieter Riemensperger. "Asymmetric Presynaptic Depletion of Dopamine Neurons in a Drosophila Model of Parkinson’s Disease." International Journal of Molecular Sciences 24, no. 10 (2023): 8585. http://dx.doi.org/10.3390/ijms24108585.

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Abstract:

Parkinson’s disease (PD) often displays a strong unilateral predominance in arising symptoms. PD is correlated with dopamine neuron (DAN) degeneration in the substantia nigra pars compacta (SNPC), and in many patients, DANs appear to be affected more severely on one hemisphere than the other. The reason for this asymmetric onset is far from being understood. Drosophila melanogaster has proven its merit to model molecular and cellular aspects of the development of PD. However, the cellular hallmark of the asymmetric degeneration of DANs in PD has not yet been described in Drosophila. We ectopic

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Szöllősi, Daniel. "The disease-causing mutation G108Q destabilizes the Drosophila dopamine transporter in molecular dynamic simulations." Intrinsic Activity 4, Suppl. 2 (2016): A18.26. http://dx.doi.org/10.25006/ia.4.s2-a18.26.

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