Log in

Relevant bibliographies by topics / Drug addiction – Pathophysiology / Journal articles

To see the other types of publications on this topic, follow the link: Drug addiction – Pathophysiology.

Journal articles on the topic 'Drug addiction – Pathophysiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 28 journal articles for your research on the topic 'Drug addiction – Pathophysiology.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Shippenberg, T. S., A. Zapata, and V. I. Chefer. "Dynorphin and the pathophysiology of drug addiction." Pharmacology & Therapeutics 116, no. 2 (2007): 306–21. http://dx.doi.org/10.1016/j.pharmthera.2007.06.011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Maguire, Denise. "Drug Addiction in Pregnancy: Disease Not Moral Failure." Neonatal Network 33, no. 1 (2013): 11–18. http://dx.doi.org/10.1891/0730-0832.33.1.11.

Full text

Abstract:

Nurses have demonstrated concern for years about their interactions with pregnant women who abuse drugs. Reports of nurses’ concern with substance abuse have been reported in the literature since the 1980s. As with any chronic disease, drug addiction causes physiologic changes, and the pathology that occurs in the brain drives characteristic behaviors. Research suggests that choices that addicts make are driven by pathology rather than by failure of a moral compass. This article reviews the theoretical explanations for addictive behaviors, describes the pathophysiology of drug addiction that i

APA, Harvard, Vancouver, ISO, and other styles

3

Tefahi, B., A. Yahiouche, and F. Kacha. "Adolescence and addiction." European Psychiatry 26, S2 (2011): 115. http://dx.doi.org/10.1016/s0924-9338(11)71826-0.

Full text

Abstract:

Adolescence and addiction are two different entities. Adolescence is a period characterized by a realignment risk of psychic structures, physiological and morphological. It is constructed using a reference model via the values inherited from the parents and new behaviors including consumption of drug abuse “addiction”.We illustrate our presentation with a literature review done on the PubMed database using keywords such as “adolescent, addiction, neurobiologic,pathogenesis, treatment” to study all the parameters that explain the link between adolescence and addiction from a causal model neurob

APA, Harvard, Vancouver, ISO, and other styles

4

Ali, Md Akmat, Farida Yeasmin, and MN Nag. "Addiction and Liver Disease." Medicine Today 25, no. 2 (2014): 75–83. http://dx.doi.org/10.3329/medtoday.v25i2.17926.

Full text

Abstract:

Drug induced liver disease is a global problem. The aims of the study are to know the recreational drugs causing harmful effect on liver, epidemiology of addiction; pathophysiology and their consequences. The major findings published to date concerning different agents causing addiction and liver disease, their implications with regard to understanding disease mechanisms and their amplitude or spectrum are described. Addiction not only invites lot of sufferings to the family and the country, but also responsible for different types of liver disease including fatty liver, hepatitis and liver fa

APA, Harvard, Vancouver, ISO, and other styles

5

Rao, P. S. S., Kelly O’Connell, and Thomas Kyle Finnerty. "Potential Role of Extracellular Vesicles in the Pathophysiology of Drug Addiction." Molecular Neurobiology 55, no. 8 (2018): 6906–13. http://dx.doi.org/10.1007/s12035-018-0912-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Rodrigues, Livia C. M., Pedro H. Gobira, Antonio Carlos de Oliveira, et al. "Neuroinflammation as a possible link between cannabinoids and addiction." Acta Neuropsychiatrica 26, no. 6 (2013): 334–46. http://dx.doi.org/10.1017/neu.2014.24.

Full text

Abstract:

ObjectiveSubstance dependence disorder is a chronically relapsing condition characterised by neurobiological changes leading to loss of control in restricting a substance intake, compulsion and withdrawal syndrome. In the past few years, (endo)cannabinoids have been raised as a possible target in the aetiology of drug addiction. On the other hand, although the exact mechanisms of the genesis of addiction remain poorly understood, it is possible that neuroinflammation might also play a role in the pathophysiology of this condition. Studies demonstrated that (endo)cannabinoids act as immunomodul

APA, Harvard, Vancouver, ISO, and other styles

7

Tsai, Sheng-Tzung, Hock-Kean Liew, Hao-Ming Li, Shinn-Zong Lin, and Shin-Yuan Chen. "Harnessing Neurogenesis and Neuroplasticity with Stem Cell Treatment for Addictive Disorders." Cell Transplantation 28, no. 9-10 (2019): 1127–31. http://dx.doi.org/10.1177/0963689719859299.

Full text

Abstract:

Drug and alcohol addiction has become an emerging public health issue and is a great burden to patients, their families, and society. It is characterized by high relapse rates and significant morbidity and mortality, and most available treatments result in only modest improvement. These findings highlight the necessity for new approaches to treat addiction. Scientific reports in the past two decades suggest that addiction involves impaired neural plasticity and decreased hippocampal neurogenesis. Stem cell therapy and its derived neurotrophic factors can potentially target the underlying patho

APA, Harvard, Vancouver, ISO, and other styles

8

Ivanov, Iliyan S., Kurt P. Schuiz, Robyn C. Palmero, and Jeffrey H. Newcorn. "Neurorobiology and Evidence-Based Biological Treatments for Substance Abuse Disorders." CNS Spectrums 11, no. 11 (2006): 864–77. http://dx.doi.org/10.1017/s1092852900015017.

Full text

Abstract:

ABSTRACTBehavioral patterns of addiction include compulsive drug-seeking, persistent abuse of substances despite the often dire consequences on social functioning and physical health, and the high probability of relapse even after prolonged drug-free periods.The recent focus on the biological basis of addiction has provided evidence to support the hypothesis that behavioral manifestations for addiction are influenced by biological factors, and biological factors often produce behavioral changes that can further increase risk. The current understanding of the role of the dopaminergic, glutamate

APA, Harvard, Vancouver, ISO, and other styles

9

Clasen, Matthew M., Anthony L. Riley, and Terry L. Davidson. "Hippocampal-Dependent Inhibitory Learning and Memory Processes in the Control of Eating and Drug Taking." Current Pharmaceutical Design 26, no. 20 (2020): 2334–52. http://dx.doi.org/10.2174/1381612826666200206091447.

Full text

Abstract:

As manifestations of excessive and uncontrolled intake, obesity and drug addiction have generated much research aimed at identifying common neuroadaptations that could underlie both disorders. Much work has focused on changes in brain reward and motivational circuitry that can overexcite eating and drug-taking behaviors. We suggest that the regulation of both behaviors depends on balancing excitation produced by stimuli associated with food and drug rewards with the behavioral inhibition produced by physiological “satiety” and other stimuli that signal when those rewards are unavailable. Our m

APA, Harvard, Vancouver, ISO, and other styles

10

Buonaguro, E. F., F. Marmo, L. Avvisati, et al. "Opioidergic system and N-methyl D-aspartate receptor (NMDA-R) hypofunction: Translational implications for the pathophysiology of psychosis and drug addiction." European Psychiatry 26, S2 (2011): 1231. http://dx.doi.org/10.1016/s0924-9338(11)72936-4.

Full text

Abstract:

Enkephalin is an opioidergic neuromodulator that has been implicated in long-term behavioural sensitization after administration of drugs of abuse. Enkephalin is also a molecular marker of GABAergic neurons in the striato-pallidal pathway that is involved in sensory-motor gating and has been considered dysfunctional in the pathophysiology of psychosis.In this study we investigated in male Sprague Dawley rats putative changes in Enkephalin transcripts by in situ hybridization after acute or subchronic administration of ketamine in either high or low subanaesthetic doses (50 mg/kg and 12 mg/kg r

APA, Harvard, Vancouver, ISO, and other styles

11

Hearing, Matthew C., Jakub Jedynak, Stephanie R. Ebner, et al. "Reversal of morphine-induced cell-type–specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement." Proceedings of the National Academy of Sciences 113, no. 3 (2016): 757–62. http://dx.doi.org/10.1073/pnas.1519248113.

Full text

Abstract:

Drug-evoked plasticity at excitatory synapses on medium spiny neurons (MSNs) of the nucleus accumbens (NAc) drives behavioral adaptations in addiction. MSNs expressing dopamine D1 (D1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in drug-related behaviors, and display distinct alterations in glutamate signaling following repeated exposure to psychostimulants; however, little is known of cell-type–specific plasticity induced by opiates. Here, we find that repeated morphine potentiates excitatory transmission and increases GluA2-lacking AMPA receptor expression in D1R-MSNs, whi

APA, Harvard, Vancouver, ISO, and other styles

12

Marazziti, Donatella, Silvio Presta, Stefano Baroni, Stefano Silvestri, and Liliana Dell'Osso. "Behavioral addictions: a novel challenge for psychopharmacology." CNS Spectrums 19, no. 6 (2014): 486–95. http://dx.doi.org/10.1017/s1092852913001041.

Full text

Abstract:

Although addictive syndromes have been traditionally related to substance-use disorders, during the last few decades a novel addictive group, including the so-called “behavioral or no-drug addictions,” has been recognized and has attracted increasing attention for its relevant social impact. This group includes pathological gambling, compulsive shopping, TV/Internet/social network/videogame addictions, workaholism, sex and relationship addictions, orthorexia, and overtraining syndrome. Substance and behavioral addictions show similar phenomenological features, such as craving, dependence, tole

APA, Harvard, Vancouver, ISO, and other styles

13

Brzezicki, Maksymilian Aleksander, and Przemyslaw Temistokles Zakowicz. "Mambalgins, the Venom-origin Peptides as a Potentially Novel Group of Analgesics: Mini Review." CNS & Neurological Disorders - Drug Targets 17, no. 2 (2018): 87–97. http://dx.doi.org/10.2174/1871527317666171221110419.

Full text

Abstract:

Background: Despite a wide variety of current analgesia regimens, chronic pain is an incredibly difficult condition to treat. Its pathophysiology, initiation, development and course involve a range of different receptors and transmitters. The acid-sensing ion channels (ASICs) are being attributed to an increasingly larger significance in pain aetiology. Over the last few years, the mechanism of ASICs action, influence of their antagonists/agonists and clinical applications have been well described. However, the importance of this protein is significantly larger, not only from the perspective o

APA, Harvard, Vancouver, ISO, and other styles

14

Pettorruso, Mauro, Luisa De Risio, Giovanni Martinotti, et al. "Targeting the Glutamatergic System to Treat Pathological Gambling: Current Evidence and Future Perspectives." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/109786.

Full text

Abstract:

Pathological gambling or gambling disorder has been defined by the DSM-5 as a behavioral addiction. To date, its pathophysiology is not completely understood and there is no FDA-approved treatment for gambling disorders. Glutamate is the principal excitatory neurotransmitter in the nervous system and it has been recently involved in the pathophysiology of addictive behaviors. In this paper, we review the current literature on a class of drugs that act as modulating glutamate system in PG. A total of 19 studies have been included, according to inclusion and exclusion criteria. Clinical trial an

APA, Harvard, Vancouver, ISO, and other styles

15

Ho, Roger C. M., and Melvyn W. Zhang. "Ketamine as a rapid antidepressant: the debate and implications." BJPsych Advances 22, no. 4 (2016): 222–33. http://dx.doi.org/10.1192/apt.bp.114.014274.

Full text

Abstract:

SummaryKetamine, a synthetic derivative of phencyclidine, is a commonly misused party drug that is restricted in high-income countries because of its addictive potential. Ketamine is also used as an anaesthetic in human and veterinary medicine. In the 1990s, research using ketamine to study the pathophysiology of schizophrenia was terminated owing to ethical concerns. Recently, controversy surrounding the drug has returned, as researchers have demonstrated that intravenous ketamine infusion has a rapid antidepressant effect and have therefore proposed ketamine as a novel antidepressant. This a

APA, Harvard, Vancouver, ISO, and other styles

16

Tonstad, Serena, and Charl Els. "Varenicline: Smoking Cessation in Patients with Medical and Psychiatric Comorbidity." Clinical Medicine Insights: Therapeutics 2 (January 2010): CMT.S4012. http://dx.doi.org/10.4137/cmt.s4012.

Full text

Abstract:

Smoking remains a major public health challenge. Nicotine is the main psychoactive drug responsible for the addictive nature of tobacco, explaining why many smokers fail to quit without assistance. Pharmacotherapy for smoking cessation is deemed effective for a broad range of populations and should be routinely offered to smokers interested in making a quit attempt. Varenicline, a partial agonist at the α4β2 nicotinic receptor increases chances of quitting three-fold compared to placebo in smokers without comorbidities, and in smokers with cardiovascular disease or chronic obstructive pulmonar

APA, Harvard, Vancouver, ISO, and other styles

17

McCarty, Dana B., Jennifer R. Peat, Shannon O'Donnell, Elisabeth Graham, and William F. Malcolm. "“Choose Physical Therapy” for Neonatal Abstinence Syndrome: Clinical Management for Infants Affected by the Opioid Crisis." Physical Therapy 99, no. 6 (2019): 771–85. http://dx.doi.org/10.1093/ptj/pzz039.

Full text

Abstract:

Abstract In response to the opioid crisis, the American Physical Therapy Association has strongly advocated for physical therapy as a safe alternative to pharmacological pain management through the “#ChoosePT” campaign and the dedication of a PTJ special issue to the nonpharmacological management of pain. Physical therapists not only play an important role in the rehabilitation of the nearly 2 million adolescents and adults addicted to prescription opioids but also provide care to infants born to mothers with various drug addictions. This Perspective article explores the incidence, pathophysio

APA, Harvard, Vancouver, ISO, and other styles

18

Tremey, A., I. de Chazeron, G. Brousse, and P. M. Llorca. "Punding in Parkinson's disease: To a better understanding of a common phenomenon between Parkinson's disease and addictions." European Psychiatry 33, S1 (2016): S145. http://dx.doi.org/10.1016/j.eurpsy.2016.01.251.

Full text

Abstract:

IntroductionPunding is a stereotypical motor behaviour characterized by a repetitive, excessive and non-goal oriented activity that causes an important loss of time. Since its first description in psychostimulant addicts, data on punding has only derived from studies on Parkinsonian patients treated with dopaminergic drugs. Little is known in the literature about Parkinsonian patient's characteristics who suffer from punding.ObjectiveWe propose to study characteristics of Parkinsonian “punders” in order to investigate the pathophysiology of this phenomenon.MethodsIn this retrospective study, w

APA, Harvard, Vancouver, ISO, and other styles

19

Hámor, Peter U., and Marek Schwendt. "Metabotropic Glutamate Receptor Trafficking and its Role in Drug-Induced Neurobehavioral Plasticity." Brain Plasticity, March 26, 2021, 1–16. http://dx.doi.org/10.3233/bpl-210120.

Full text

Abstract:

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that guides developmental and experience-dependent changes in many cellular substrates and brain circuits, through the process collectively referred to as neurobehavioral plasticity. Regulation of cell surface expression and membrane trafficking of glutamate receptors represents an important mechanism that assures optimal excitatory transmission, and at the same time, also allows for fine-tuning neuronal responses to glutamate. On the other hand, there is growing evidence implicating dysregulated glutama

APA, Harvard, Vancouver, ISO, and other styles

20

"Drug Addiction in Pakistan: A step towards alleviation of sufferings." Journal of Sheikh Zayed Medical College 12, no. 1 (2021): 1–2. http://dx.doi.org/10.47883/jszmc.v12i1.3.

Full text

Abstract:

Addiction is a complex mental and behavioral disorder that changes the neurochemistry and physiology of the brain. Genetics also plays a significant role in the pathophysiology of addiction.1 Drug addiction, whether it is mono or poly drug addiction is a major problem in Pakistan, it is defined as a maladaptive form of drug or illicit use leading to clinically significant distress or impairment, while an individual may also suffer from withdrawal and tolerance. As we know that drug addiction or abuse is a common problem worldwide, including Pakistan.2 According to World Health Organization (WH

APA, Harvard, Vancouver, ISO, and other styles

21

Lei, Wei, Kezhi Liu, Guangxiang Chen, et al. "Blunted reward prediction error signals in internet gaming disorder." Psychological Medicine, November 4, 2020, 1–10. http://dx.doi.org/10.1017/s003329172000402x.

Full text

Abstract:

Abstract Background Internet gaming disorder (IGD) is a type of behavioural addictions. One of the key features of addiction is the excessive exposure to addictive objectives (e.g. drugs) reduces the sensitivity of the brain reward system to daily rewards (e.g. money). This is thought to be mediated via the signals expressed as dopaminergic reward prediction error (RPE). Emerging evidence highlights blunted RPE signals in drug addictions. However, no study has examined whether IGD also involves alterations in RPE signals that are observed in other types of addictions. Methods To fill this gap,

APA, Harvard, Vancouver, ISO, and other styles

22

Moeller, F. Gerard. "Substance Use Disorders." DeckerMed Medical Cannabis, June 25, 2018. http://dx.doi.org/10.2310/cannabis.1191.

Full text

Abstract:

There is a consistent body of evidence showing that substance abuse and dependence can worsen preexisting medical conditions, can temporarily mimic medical and psychiatric disorders, and can themselves cause medical problems, including life-threatening overdose. Substance use disorders are common in young and middle-aged persons: the lifetime prevalence of these syndromes, including alcoholism, is over 20% for men and about 15% for women. This chapter discusses dependence, abuse, substance use disorder, and substance-induced disorders involving depressants, stimulants, opioids, cannabinoids, h

APA, Harvard, Vancouver, ISO, and other styles

23

Moeller, F. Gerard. "Substance Use Disorders." DeckerMed Medical Cannabis, June 25, 2018. http://dx.doi.org/10.2310/cannabis.1191.

Full text

Abstract:

There is a consistent body of evidence showing that substance abuse and dependence can worsen preexisting medical conditions, can temporarily mimic medical and psychiatric disorders, and can themselves cause medical problems, including life-threatening overdose. Substance use disorders are common in young and middle-aged persons: the lifetime prevalence of these syndromes, including alcoholism, is over 20% for men and about 15% for women. This chapter discusses dependence, abuse, substance use disorder, and substance-induced disorders involving depressants, stimulants, opioids, cannabinoids, h

APA, Harvard, Vancouver, ISO, and other styles

24

Moeller, F. Gerard. "Substance Use Disorders." DeckerMed Medicine, June 25, 2018. http://dx.doi.org/10.2310/im.1191.

Full text

Abstract:

There is a consistent body of evidence showing that substance abuse and dependence can worsen preexisting medical conditions, can temporarily mimic medical and psychiatric disorders, and can themselves cause medical problems, including life-threatening overdose. Substance use disorders are common in young and middle-aged persons: the lifetime prevalence of these syndromes, including alcoholism, is over 20% for men and about 15% for women. This chapter discusses dependence, abuse, substance use disorder, and substance-induced disorders involving depressants, stimulants, opioids, cannabinoids, h

APA, Harvard, Vancouver, ISO, and other styles

25

Aishwarya, Richa, Chowdhury S. Abdullah, Mahboob Morshed, Naznin Sultana Remex, and Md Shenuarin Bhuiyan. "Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology." Frontiers in Physiology 12 (July 7, 2021). http://dx.doi.org/10.3389/fphys.2021.705575.

Full text

Abstract:

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in Sigmar1 have been identified as a causative gene for neuronal and neuromuscular disorder. Since the discovery over 40 years ago, Sigmar1 has been shown to contribute to numerous cellular functions, including ion channel regulation, protein quality control, endoplasmic reticulum-mitochondrial communication, lipid metabolism, mitochondrial function, autophagy activation, and involved in cellular survival. Alterat

APA, Harvard, Vancouver, ISO, and other styles

26

Sagheddu, Claudia, Larissa Helena Torres, Tania Marcourakis, and Marco Pistis. "Endocannabinoid-Like Lipid Neuromodulators in the Regulation of Dopamine Signaling: Relevance for Drug Addiction." Frontiers in Synaptic Neuroscience 12 (December 23, 2020). http://dx.doi.org/10.3389/fnsyn.2020.588660.

Full text

Abstract:

The family of lipid neuromodulators has been rapidly growing, as the use of different -omics techniques led to the discovery of a large number of naturally occurring N-acylethanolamines (NAEs) and N-acyl amino acids belonging to the complex lipid signaling system termed endocannabinoidome. These molecules exert a variety of biological activities in the central nervous system, as they modulate physiological processes in neurons and glial cells and are involved in the pathophysiology of neurological and psychiatric disorders. Their effects on dopamine cells have attracted attention, as dysfuncti

APA, Harvard, Vancouver, ISO, and other styles

27

Nahar, Lailun, Blake M. Delacroix, and Hyung W. Nam. "The Role of Parvalbumin Interneurons in Neurotransmitter Balance and Neurological Disease." Frontiers in Psychiatry 12 (June 18, 2021). http://dx.doi.org/10.3389/fpsyt.2021.679960.

Full text

Abstract:

While great progress has been made in the understanding of neurological illnesses, the pathologies, and etiologies that give rise to these diseases still remain an enigma, thus, also making treatments for them more challenging. For effective and individualized treatment, it is beneficial to identify the underlying mechanisms that govern the associated cognitive and behavioral processes that go awry in neurological disorders. Parvalbumin fast-spiking interneurons (Pv-FSI) are GABAergic cells that are only a small fraction of the brain's neuronal network, but manifest unique cellular and molecul

APA, Harvard, Vancouver, ISO, and other styles

28

Kaye, Alan D., Martin J. Carney, Mark R. Jones, Harold J. Campbell, and Burton R. Beakley. "Patient with a History of Active Substance Abuse Requesting Opioids for Chronic Pain." DeckerMed Pain Management, January 27, 2021. http://dx.doi.org/10.2310/pm.15051.

Full text

Abstract:

Health care providers face a considerable challenge when treating chronic pain patients with prescription opioid medications. Although indications exist for the use of these drugs, their addictive nature and street value render them high-risk targets for abuse, misuse, and diversion. All patients receiving opioids should, therefore, be screened for abuse potential before beginning opioid therapy, be required to sign an opioid agreement, and receive close monitoring throughout the course of their treatment. Patients who present with a history of active substance abuse are at higher risk for iat

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!