Relevant bibliographies by topics / Drug content uniformity

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Drug content uniformity'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Drug content uniformity"

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Kurćubić, Ivana, Sandra Cvijić, Milica Lukić, Svetlana Ibrić, and Jelena Đuriš. "Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: Propranolol case study." Arhiv za farmaciju 71, no. 2 (2021): 141–59. http://dx.doi.org/10.5937/arhfarm71-30717.

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The development of solid dosage forms that are both convenient for administration and allow precise drug dosing for pediatric patients is one of the great challenges in contemporary pharmaceutical technology. The presented study has utilized propranolol hydrochloride, as one of the most frequently prescribed drugs that require manipulation of the conventional dosage forms to be administered to children. Multiparticulate oral formulations, powderand granulefilled capsules, as well as mini tablets, were prepared and characterized in terms of their mass and content uniformity and compared to conv
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Buyukgoz, Guluzar G., Jeremiah N. Castro, Andrew E. Atalla, John G. Pentangelo, Siddharth Tripathi, and Rajesh N. Davé. "Impact of Mixing on Content Uniformity of Thin Polymer Films Containing Drug Micro-Doses." Pharmaceutics 13, no. 6 (2021): 812. http://dx.doi.org/10.3390/pharmaceutics13060812.

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The impact of mixer type and critical process parameters (CPPs) on critical quality attributes (CQAs), including the drug content uniformity (CU) of slurry-cast polymer films loaded with micro-sized poorly water-soluble drugs were investigated. Previously untested hypothesis was that the best mixer at suitable CPPs promotes uniform drug dispersion within film precursors leading to acceptable dried-film CU at low, ~0.6 wt% drug concentrations. Taguchi design was utilized to select the best of three mixers; low-shear impeller, high-shear planetary, and high-intensity vibrational, for dried-film
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Eserian, Jaqueline Kalleian, and Márcia Lombardo. "EVALUATION OF QUALITY ATTRIBUTES OF PROPRANOLOL SPLIT TABLETS: FOCUS ON DOSE VARIABILITY." Infarma - Ciências Farmacêuticas 29, no. 4 (2017): 371–78. http://dx.doi.org/10.14450/2318-9312.v29.e4.a2017.pp371-378.

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Tablet splitting is a widespread practice among patients and health professionals aiming the administration of lower doses and the reduction of the cost of prescriptions. Nevertheless, potential concerns such as weight variation, stability and uneven drug content of the halves are related to this practice. The objective of this study was to evaluatethe uniformity of half-tablets regarding weight and drug content in three different commercial products containing propranolol. Also, it was assessed drug content for whole tablets. Weight variation and drug content uniformity tests were evaluated f
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Jakubowska, Emilia, and Natalia Ciepluch. "Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review." Pharmaceutics 13, no. 11 (2021): 1909. http://dx.doi.org/10.3390/pharmaceutics13111909.

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Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend homogeneity, or may result from further particle segregation during storage, transfer or the compression process itself. This review presents the most relevant powder segregation mechanisms in tablet manufacturing and summarizes the currently available, up-to-date research on segregation and uniformity l
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Carstensen, J. T., and Mandar V. Dali. "Blending Validation and Content Uniformity of Low-Content, Noncohesive Powder Blends." Drug Development and Industrial Pharmacy 22, no. 4 (1996): 285–90. http://dx.doi.org/10.3109/03639049609041991.

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Nur, Amran, Ermalyanti Fiskia, and Bambang Tjiroso. "Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP." E3S Web of Conferences 328 (2021): 01001. http://dx.doi.org/10.1051/e3sconf/202132801001.

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The high-density gastroretentive dosage forms was made a high-density theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. The polymer used sodium alginate and PVP K30, where the 1st formula ratio of sodium alginate: PVP K30 (18.75%: 5%), the 2nd formula ratio of sodium alginate: PVP K30 (18.75%: 2, 5%) and 3th formula ratio of sodium alginate: PVP K30 (12.5%: 2.5%). The third formula were evaluated with weight uniformity test, size uniformity test, hardness test, drug content test, in vitro release test, as well as the determination o
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Nautiyal, Ujjawal, and Devendra Singh. "Formulation and Characterization of Transdermal Patches of Losartan." Indian Journal of Pharmaceutical and Biological Research 1, no. 01 (2013): 44–54. http://dx.doi.org/10.30750/ijpbr.1.1.4.

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Administration of drugs through skin has received great attention through the last decade.Hence this study aims to formulate an anti-hypertensive drug losartan as transdermal patch using different bioadhesive polymers such as ethyl cellulose, cellulose acetate, and polyvinyl pyrrolidon,hydroxyl propylemethylcellulose with plasticizers propylene glycol(PG). Patches were prepared though solvent evaporation method, The backing membrane was a non permeable aluminium foil laminated with polyethylene and evaluated for thickness uniformity, Uniformity of weight, Scanning Electron Microscopy, Surface
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Pooja R, Ashok Kumar P, Manjunath K, and Darshan A. "Formulation and evaluation of doxepin hydrochloride by fast dissolving buccal film." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 327–35. http://dx.doi.org/10.30574/wjarr.2022.16.1.0946.

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may also have analgesic neighborhood effect due to its biochemical mechanism of action. This is commonly performed via drug to be administers directly into the blood flow via the Buccal mucosa through using fast dissolving movie system. The main aim of the study was to formulate and evaluate Doxepin hydrochloride by fast dissolving buccal film. The Doxepin hydrochloride buccal film were prepared by the solvent casting method by using the different polymers (HPMC E15, PVA, and HEC). The FTIR test is conducted by this test there was no in
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Pooja, R., Kumar P. Ashok, K. Manjunath, and A. Darshan. "Formulation and evaluation of doxepin hydrochloride by fast dissolving buccal film." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 327–35. https://doi.org/10.5281/zenodo.7769241.

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may also have analgesic neighborhood effect due to its biochemical mechanism of action. This is commonly performed via drug to be administers directly into the blood flow via the Buccal mucosa through using fast dissolving movie system. The main aim of the study was to formulate and evaluate Doxepin hydrochloride by fast dissolving buccal film. The Doxepin hydrochloride buccal film were prepared by the solvent casting method by using the different polymers (HPMC E15, PVA, and HEC). The FTIR test is conducted by this test there was no in
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Owusu, Frederick William Akuffo, Mariam El Boakye-Gyasi, Philomena Entsie, et al. "Formulation and Pharmaceutical Assessment of Annona muricata Oral Capsules and Suspension as Antidiarrhea Dosage Forms." Journal of Chemistry 2021 (December 14, 2021): 1–6. http://dx.doi.org/10.1155/2021/1792437.

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Annona muricata (Annonaceae) is a tropical plant widely known for its edible fruits. Recent scientific studies have confirmed the folkloric use of its seeds as an antidiarrheal agent. This study sought to formulate capsules and suspensions using the ethanolic extract from Annona muricata seeds. The dried ethanolic extract was formulated into granules and subsequently encapsulated. The suspension formulated was assessed for sedimentation rate, sedimentation volume, viscosity, dissolution, drug content, and flow rate, while pharmacopeia tests such as disintegration, dissolution, uniformity of we
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Dissertations / Theses on the topic "Drug content uniformity"

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Hill, Shaynan, and Andrew Varker. "Drug Content and Weight Uniformity for Six Commonly Split Medications." The University of Arizona, 2008. http://hdl.handle.net/10150/624306.

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Class of 2008 Abstract<br>Objectives: To determine the active drug content and weight uniformity for half tablets of commonly split medications as a means to outline the safety and efficacy of tablet splitting. Methods: This analytical study was performed using the following six medications: warfarin, simvastatin, metoprolol succinate, metoprolol tartrate, citalopram, and lisinopril. Whole tablets (n=15) and half tablets (n= 30) were analyzed for drug content using high pressure liquid chromatography as compared to established standard curves. Weight uniformity was assessed using half tablet
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Lunney, Phillip. "Improvement of Release Criteria for Immediate Release Solid Oral Dosage Forms." 2012. http://digital.library.duq.edu/u?/etd,154147.

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Herewith are presented the results of an investigation the statistical power of USP compendial release tests and recommended alternatives. &lt;br&gt;The U.S. drug supply chain, formerly protected by a closed distribution network, is now threatened by the legal and illegal importation of drug products. Whereas quality can never be inspected into final products, compendial release standards may represent the only valid assessment that products of dubious origin would receive. Reliable tests for content uniformity and dissolution are required to protect the safety of the supply chain. A study wa
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Book chapters on the topic "Drug content uniformity"

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Johnson, Kevin C. "Particle Size of Drug Substance and Product Content Uniformity-Theoretical Considerations." In Formulation and Analytical Development for Low-Dose Oral Drug Products. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470386361.ch3.

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Bossi, Paolo, and Luigi Lorini. "Optimal Supportive Measures during Primary Treatment." In Critical Issues in Head and Neck Oncology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_15.

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AbstractSupportive care during curative treatment of head and neck cancer patients has different scopes: reducing the burden of acute toxicities and limiting the risk of developing late adverse effects; increasing the quality of life of the patients; allowing to perform optimal curative therapy, maintaining treatment dose intensity; preventing higher grade toxicities so to reduce also the costs associated with hospitalization, examinations, visits and use of drugs. At the same time, it is necessary to give uniformity in the supportive care protocols, as these preventive and therapeutic measure
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Zahorulko, Andrii, Aleksey Zagorulko, Sofiia Minenko, and Iryna Bozhydai. "Scientific and practical justification of innovative approaches to production of multicomponent semi-finished products for food products in the conditions of food security of the country." In FOOD PRODUCTION: INNOVATIVE TECHNOLOGICAL SOLUTIONS. TECHNOLOGY CENTER PC, 2024. https://doi.org/10.15587/978-617-7319-99-2.ch3.

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The production of functional products in the form of independent and multicomponent compositions based on vegetable semi-finished products of a high degree of readiness for further use during the manufacture of various food products is proposed. The proposed adaptive mechanism makes it possible to simulate the competitiveness of the agro-industrial sector in the conditions of taking into account the flow parameters of traditional micro- and macro-environments for the optimal adaptation of innovative approaches when implementing resource-saving hardware and technological solutions. A resource-s
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Saha, Gourab. "Capsules." In A Text Book of Pharmaceutics for I Year Diploma in Pharmacy. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/ghtjh139.

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Capsules are versatile solid dosage forms that offer unique advantages in drug delivery and patient acceptance. This section covers both hard and soft gelatin capsules, exploring their composition, manufacturing processes, and applications. The properties of gelatin and alternative shell materials, including vegetable-based and hydroxypropyl methylcellulose (HPMC) capsules, are discussed in relation to their impact on drug stability and release. Capsule filling processes for powders, granules, pellets, and liquids are examined, including manual, semi-automatic, and fully automatic filling meth
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Shanmugasundaram, Sangeetha. "Mixing." In A Text Book of Pharmaceutics for I Year Diploma in Pharmacy. THINKPLUS PHARMA PUBLICATIONS, 2024. http://dx.doi.org/10.69613/x4nmzs87.

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Mixing is a fundamental unit operation in pharmaceutical manufacturing, essential for achieving homogeneity in various formulations. This process involves the combination of two or more components to produce a uniform mixture, crucial for ensuring consistent drug content and performance. Different types of mixing are employed based on the physical state of materials, including solid-solid, solid-liquid, and liquid-liquid mixing. The selection of appropriate mixing equipment, such as ribbon blenders, planetary mixers, or high-shear mixers, depends on the nature of the materials and desired outc
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Saltzman, W. Mark. "Diffusion and Drug Dispersion." In Drug Delivery. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780195085891.003.0008.

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Most biological processes occur in an environment that is predominantly water: a typical cell contains 70-85% water and the extracellular space of most tissues is 99%. Even the brain, with its complex arrangement of cells and myelinated processes, is ≈ 80% water. Drug molecules can be introduced into the body in a variety of ways; the effectiveness of drug therapy depends on the rate and extent to which drug molecules can move through tissue structures to reach their site of action. Since water serves as the primary milieu for life processes, it is essential to understand the factors that dete
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Makandar, Shahussen, Nataraj J R, Shivaraj B W, and Sham Aan. "SYNTHESIS AND CHARACTERIZATION OF HYDROPHOBIC SURFACE USING METAL OXIDES THIN FILMS." In Futuristic Trends in Mechanical Engineering Volume 3 Book 5. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bdme5p1ch4.

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Hydrophobic surfaces play vital role in the solving the technological problems such as marine fouling, anticorrosion and drag reduction. For the synthesis of Nanoparticles such as Zinc Oxide (ZnO), Copper Oxide (CuO) and Ferrous Oxide (Fe2O3) Solution Combustion Method was used. Spin coating method was used to prepare hydrophobic surfaces. ZnO, CuO and Fe2O3 was mixed separately with Polystyrene (PS) and THF solution then magnetically stirred to get uniform dispersion of particles and heated to form gel. This gel was further spin coated on to the glass substrate to form ZnO/PS, CuO/PS and Fe2O
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DeLong, D. H. Sterman P. A. "Gene therapy for malignant pleural mesothelioma." In Malignant Pleural Mesothelioma. Oxford University PressOxford, 2006. http://dx.doi.org/10.1093/oso/9780198529309.003.0019.

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Abstract Malignant pleural mesothelioma (MPM) is minimally responsive to most chemotherapy and radiotherapy regimens, and is almost uniformly fatal. Radiation therapy is primarily useful for palliation of localized chest wall invasion or after debulking surgery. Furthermore, radical surgical resection of all involved pleural surfaces, ipsilateral lung, pericardium, and diaphragm has not been demonstrated to prolong survival, although non-randomized large phase II studies have yielded encouraging results in highly selected groups of patients as part of multimodality treatment involving surgery,
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Conference papers on the topic "Drug content uniformity"

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Patel, Abhishek D., and Amit Thakkar. "Drug Uniformity and Content Detection for Pharmaceutical Formulations: The Deep Learning Approach." In FIRE 2023: Forum for Information Retrieval Evaluation. ACM, 2023. http://dx.doi.org/10.1145/3632754.3632768.

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Shady, Sally F., and Stephen McCarthy. "Effects of Vinyl Acetate Content and Extrusion Temperatures on Ethylene Vinyl Acetate (EVA) Tetracycline HCL Fibers Used for Periodontal Applications." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66216.

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Periodontal disease is a prevalent disease that effects all types of ages. Mild cases of periodontal disease include infection and gingivitis. Severe cases of periodontal disease include loss of teeth, and the increased likelihood of systemic diseases such as: cancer, osteoporosis and pneumonia. Current treatments of periodontal disease include systemic approaches such as oral tablets of antibiotics or localized treatments such as the periodontal chip. Oral antibiotics require high dosages to effectively treat the infection therefore causing unwanted side effects. Other treatments include surg
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Akseki, Ilgaz, Christopher F. Libordi, and Cetin Cetinkaya. "Non-Contact Acoustic Techniques for Drug Tablet Monitoring." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-13940.

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Quality assurance monitoring and material characterization is of great importance in the pharmaceutical industry. If the tablet coating and/or core are defective, the desired dose delivery and bioavailability can be compromised. Tablet coatings serve a wide variety of purposes such as regulating controlled release of active ingredients in the body, contributing to the bioavailability of a particular drug or combination of drugs, during certain times and locations within the body, protecting the stomach from high concentrations of active ingredients, extending the shelf life by protecting the i
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Khmelovskyi, Vasyl, Yulii Revenko, Victor Rebenko, and Svitlana Potapova. "Features of grinding and mixing feed components in hammer mill." In 24th International Scientific Conference Engineering for Rural Development. Latvia University of Life Sciences and Technologies, Faculty of Engineering and Information Technologies, 2025. https://doi.org/10.22616/erdev.2025.24.tf161.

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The efficiency of the process of grinding and mixing feed in hammer mills depends on various controllable factors, including the speed of the hammers, the size of the sieve holes, the density of hammers on the drum, the mass fraction of the control component, and the shape of the hammer. With the same parameters of the hammer mill and grain moisture content of different crops, products with different indicators of grinding uniformity were obtained during processing. The average particle size of the grinding products differed by 10-17%, and the uniformity of their fractional composition by 5-13
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Nishizawa, E. E., and D. J. Williams. "PERIVASCULAR CAROTID ARTERY INJURY LEAD TO ATHEROSCLEROSIS IN HYPERCHOLESTEROLEMIC RABBITS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643085.

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We have previously shown that endothelial injury results when clotted blood is placed perivascularly around a rabbit carotid artery. This injury was manifested by loss of endothelial cells and adherence of leukocytes and platelets. When similar injury was induced in hypercholesterolemic rabbits, medial lesions as well as intimal proliferation was observed. We have extended these studies and have found that these lesions contain high concentrations of cholesterol (200-300 mg/gm protein compared to 40-80 mg/gm protein in controls) suggesting lipid infiltration. The uniformity of lipid accumulati
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Cable, Travis A., and Luis San Andrés. "On the Design, Manufacture and Premature Failure of a Metal Mesh Thrust Bearing: How Concepts That Work on Paper, Actually Do Not." In ASME Turbo Expo 2018: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/gt2018-75340.

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Oil-free micro turbomachinery (OFT) implements compliant foil bearings because of their minute drag and ability to operate in extreme (high or low) temperature. Prominent to date, bump-type foil bearings integrate an underspring thin metal structure that provides resilience and material damping; and while the rotor is airborne, acts in series with the stiffness and damping of the gas film. The design and manufacturing of foil bearings remains costly as it demands of extensive engineering and actual experience. Alternative foil bearing configurations, less costly and easier to manufacture, are
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