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Journal articles on the topic 'Drug content uniformity'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kurćubić, Ivana, Sandra Cvijić, Milica Lukić, Svetlana Ibrić, and Jelena Đuriš. "Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: Propranolol case study." Arhiv za farmaciju 71, no. 2 (2021): 141–59. http://dx.doi.org/10.5937/arhfarm71-30717.

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The development of solid dosage forms that are both convenient for administration and allow precise drug dosing for pediatric patients is one of the great challenges in contemporary pharmaceutical technology. The presented study has utilized propranolol hydrochloride, as one of the most frequently prescribed drugs that require manipulation of the conventional dosage forms to be administered to children. Multiparticulate oral formulations, powderand granulefilled capsules, as well as mini tablets, were prepared and characterized in terms of their mass and content uniformity and compared to conv

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2

Buyukgoz, Guluzar G., Jeremiah N. Castro, Andrew E. Atalla, John G. Pentangelo, Siddharth Tripathi, and Rajesh N. Davé. "Impact of Mixing on Content Uniformity of Thin Polymer Films Containing Drug Micro-Doses." Pharmaceutics 13, no. 6 (2021): 812. http://dx.doi.org/10.3390/pharmaceutics13060812.

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The impact of mixer type and critical process parameters (CPPs) on critical quality attributes (CQAs), including the drug content uniformity (CU) of slurry-cast polymer films loaded with micro-sized poorly water-soluble drugs were investigated. Previously untested hypothesis was that the best mixer at suitable CPPs promotes uniform drug dispersion within film precursors leading to acceptable dried-film CU at low, ~0.6 wt% drug concentrations. Taguchi design was utilized to select the best of three mixers; low-shear impeller, high-shear planetary, and high-intensity vibrational, for dried-film

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3

Eserian, Jaqueline Kalleian, and Márcia Lombardo. "EVALUATION OF QUALITY ATTRIBUTES OF PROPRANOLOL SPLIT TABLETS: FOCUS ON DOSE VARIABILITY." Infarma - Ciências Farmacêuticas 29, no. 4 (2017): 371–78. http://dx.doi.org/10.14450/2318-9312.v29.e4.a2017.pp371-378.

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Tablet splitting is a widespread practice among patients and health professionals aiming the administration of lower doses and the reduction of the cost of prescriptions. Nevertheless, potential concerns such as weight variation, stability and uneven drug content of the halves are related to this practice. The objective of this study was to evaluatethe uniformity of half-tablets regarding weight and drug content in three different commercial products containing propranolol. Also, it was assessed drug content for whole tablets. Weight variation and drug content uniformity tests were evaluated f

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4

Jakubowska, Emilia, and Natalia Ciepluch. "Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review." Pharmaceutics 13, no. 11 (2021): 1909. http://dx.doi.org/10.3390/pharmaceutics13111909.

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Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend homogeneity, or may result from further particle segregation during storage, transfer or the compression process itself. This review presents the most relevant powder segregation mechanisms in tablet manufacturing and summarizes the currently available, up-to-date research on segregation and uniformity l

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5

Carstensen, J. T., and Mandar V. Dali. "Blending Validation and Content Uniformity of Low-Content, Noncohesive Powder Blends." Drug Development and Industrial Pharmacy 22, no. 4 (1996): 285–90. http://dx.doi.org/10.3109/03639049609041991.

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Nur, Amran, Ermalyanti Fiskia, and Bambang Tjiroso. "Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP." E3S Web of Conferences 328 (2021): 01001. http://dx.doi.org/10.1051/e3sconf/202132801001.

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The high-density gastroretentive dosage forms was made a high-density theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. The polymer used sodium alginate and PVP K30, where the 1st formula ratio of sodium alginate: PVP K30 (18.75%: 5%), the 2nd formula ratio of sodium alginate: PVP K30 (18.75%: 2, 5%) and 3th formula ratio of sodium alginate: PVP K30 (12.5%: 2.5%). The third formula were evaluated with weight uniformity test, size uniformity test, hardness test, drug content test, in vitro release test, as well as the determination o

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7

Nautiyal, Ujjawal, and Devendra Singh. "Formulation and Characterization of Transdermal Patches of Losartan." Indian Journal of Pharmaceutical and Biological Research 1, no. 01 (2013): 44–54. http://dx.doi.org/10.30750/ijpbr.1.1.4.

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Administration of drugs through skin has received great attention through the last decade.Hence this study aims to formulate an anti-hypertensive drug losartan as transdermal patch using different bioadhesive polymers such as ethyl cellulose, cellulose acetate, and polyvinyl pyrrolidon,hydroxyl propylemethylcellulose with plasticizers propylene glycol(PG). Patches were prepared though solvent evaporation method, The backing membrane was a non permeable aluminium foil laminated with polyethylene and evaluated for thickness uniformity, Uniformity of weight, Scanning Electron Microscopy, Surface

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8

Pooja R, Ashok Kumar P, Manjunath K, and Darshan A. "Formulation and evaluation of doxepin hydrochloride by fast dissolving buccal film." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 327–35. http://dx.doi.org/10.30574/wjarr.2022.16.1.0946.

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may also have analgesic neighborhood effect due to its biochemical mechanism of action. This is commonly performed via drug to be administers directly into the blood flow via the Buccal mucosa through using fast dissolving movie system. The main aim of the study was to formulate and evaluate Doxepin hydrochloride by fast dissolving buccal film. The Doxepin hydrochloride buccal film were prepared by the solvent casting method by using the different polymers (HPMC E15, PVA, and HEC). The FTIR test is conducted by this test there was no in

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Pooja, R., Kumar P. Ashok, K. Manjunath, and A. Darshan. "Formulation and evaluation of doxepin hydrochloride by fast dissolving buccal film." World Journal of Advanced Research and Reviews 16, no. 1 (2022): 327–35. https://doi.org/10.5281/zenodo.7769241.

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Tricyclic antidepressants, as doxepin hydrochloride (DH), may also have analgesic neighborhood effect due to its biochemical mechanism of action. This is commonly performed via drug to be administers directly into the blood flow via the Buccal mucosa through using fast dissolving movie system. The main aim of the study was to formulate and evaluate Doxepin hydrochloride by fast dissolving buccal film. The Doxepin hydrochloride buccal film were prepared by the solvent casting method by using the different polymers (HPMC E15, PVA, and HEC). The FTIR test is conducted by this test there was no in

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10

Owusu, Frederick William Akuffo, Mariam El Boakye-Gyasi, Philomena Entsie, et al. "Formulation and Pharmaceutical Assessment of Annona muricata Oral Capsules and Suspension as Antidiarrhea Dosage Forms." Journal of Chemistry 2021 (December 14, 2021): 1–6. http://dx.doi.org/10.1155/2021/1792437.

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Annona muricata (Annonaceae) is a tropical plant widely known for its edible fruits. Recent scientific studies have confirmed the folkloric use of its seeds as an antidiarrheal agent. This study sought to formulate capsules and suspensions using the ethanolic extract from Annona muricata seeds. The dried ethanolic extract was formulated into granules and subsequently encapsulated. The suspension formulated was assessed for sedimentation rate, sedimentation volume, viscosity, dissolution, drug content, and flow rate, while pharmacopeia tests such as disintegration, dissolution, uniformity of we

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11

BEYATRICKS, JESINDHA, and ,. Dhananjaya. "Development of Fast Dissolving Oral Films Containing Vitamin B6 for Nausea and Vomiting of Pregnancy (NVP)." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 51–59. http://dx.doi.org/10.22270/jddt.v9i3.2735.

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The aim of this study was to formulate and evaluate the oral fast-dissolving film of Vitamin B6 for the effective management of motion sickness and vomiting during pregnancy. Fast-dissolving films were prepared by the solvent-casting method using different polymers, HPMC-15 and Pullulan, along with Propylene glycol as a plasticizer. The Fourier-transform infrared study for the drug-polymer interaction was carried out. Evaluation of physical parameters such as physical appearance, surface texture, uniformity of weight, uniformity of strip thickness, surface pH, folding endurance, uniformity of

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Hamdan, Lama, and Jamila Husian. "FORMULATION AND EVALUATION IN VITRO A MATRIX TYPE OF KETOTIFEN FUMARATE TRANSDERMAL PATCHES FOR ALLERGIC DISEASES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 327. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.20123.

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Objective: Transdermal patches of Ketotifen fumarate (KT) were developed for prolonged effect of the drug, and to protect the patient from allergic symptoms associated with asthma and other allergic diseases.Methods: Matrix type patches were prepared by solvent casting technique using different types of polymers: Hydroxy propyl methyl cellulose (HPMC K15M) and ethyl cellulose to formed the matrix of the patch in different ratios, emulsifying agents were added as a penetration enhancers (Span 60, Tween 60, Cremophor EL) in a ratio 0.025% w/v to the matrix, 10% v/v of glycerin was added as plast

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13

Shruti Kotian, Shruti Kotian, Suraiyya Masuldar Suraiyya Masuldar, Rohit Rane Rohit Rane, Anisha Revankar Anisha Revankar, Humera Sarje Humera Sarje, and Dr Bhagyashri Joshi Dr. Bhagyashri Joshi. "Formulation Development and Evaluation of Orodispersible films of Chlorpheniramine Maleate." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1879–91. https://doi.org/10.35629/4494-100318791891.

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This study aimed to formulate Orodispersible films (ODFs) of Chlorpheniramine maleate (CPM) and develop a dosage form with rapid onset of action and ease of administration, circumventing the need to swallow or use water. The solvent casting method was employed to prepare three optimized films (F1, F2, and F3) containing varying proportions of sodium alginate and pectin as polymers, polyethylene glycol (PEG-400) and glycerol as plasticizers, sodium starch glycolate as a super disintegrant, and sodium benzoate as a preservative. The formulated ODFs were evaluated for physical characteristics suc

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14

Farquharson, Amelia, Zachery Gladding, Gary Ritchie, et al. "Drug Content Uniformity: Quantifying Loratadine in Tablets Using a Created Raman Excipient Spectrum." Pharmaceutics 13, no. 3 (2021): 309. http://dx.doi.org/10.3390/pharmaceutics13030309.

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Raman spectroscopy has proven valuable for determining the composition of manufactured drug products, as well as identifying counterfeit drugs. Here we present a simple method to determine the active pharmaceutical ingredient (API) mass percent in a sample that does not require knowledge of the identities or relative mass percents of the inactive pharmaceutical ingredients (excipients). And further, we demonstrated the ability of the method to pass or fail a manufactured drug product batch based on a calculated acceptance value in accordance with the US Pharmacopeia method for content uniformi

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15

Bohidar, N. R., Norman R. Bohidar, and Nicholas R. Bohidar. "Detection of Discordant Content Uniformity Observations and Compendial Compliance." Drug Development and Industrial Pharmacy 20, no. 5 (1994): 815–39. http://dx.doi.org/10.3109/03639049409038333.

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16

Ukwueze, S. E., and B. K. Gbimadee. "Quality Assurance and Comparative Studies of Different Brands of Pregabalin in Nigerian Pharmacies." Pharmaceutical and Chemical Journal 8, no. 2 (2021): 23–28. https://doi.org/10.5281/zenodo.13960863.

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Pregabalin, a neuropsychotropic agent, is a drug of choice for the treatment of epilepsy and neuropathic pain. Several brands are available in the Nigerian drug market which raises the challenge of determining the products that could be interchanged with the innovator brand or with other generics.  Therefore, the current study was carried out to evaluate and compare the quality and physicochemical characteristics of five different pharmaceutical brands of Pregabalin (75 mg) capsules available in the pharmacies of some southern states in Nigeria. For the brands studied, physical examinatio

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17

Cáceres-Pérez, Amor R., Mohamed B. El Kory, Javier Suárez-González, et al. "A pharmaceutical monitoring system to assess the quality of antituberculosis drug products used in Mauritania." PLOS ONE 18, no. 3 (2023): e0282023. http://dx.doi.org/10.1371/journal.pone.0282023.

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The quality of drug products may be affected from manufacture to dispensing, particularly at high temperature and humidity as in Mauritania. This country is not included in the World Health Organization reports on poor quality products due to the lack of a qualified laboratory and monitoring system. Ensuring the quality of medicine is even more relevant in the case of diseases such as Tuberculosis, due to its high prevalence, complex treatment and continuous bacterial resistance. The aim was to develop a monitoring system to assess the quality of antituberculosis drugs products, by the substan

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18

Danao, Kishor. "FORMULATION AND EVALUATION OF CONTROLLED RELEASE METOPROLOL SUCCINATE MATRIX TABLET USING NATURAL WAXES FOR THE MANAGEMENT OF HYPERTENSION." Journal of medical pharmaceutical and allied sciences 11, no. 3 (2022): 4851–57. http://dx.doi.org/10.55522/jmpas.v11i3.2336.

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Metoprolol succinate is a cardioselective β-blocker used in the management of secondary hypertension complications. Metoprolol succinate is prescribed to suppress the hypertension condition and to minimize the cardiac-related disorder. In the present study, metoprolol succinate sustained-release tablets were successfully prepared by the wet granulation method. Carnauba and beeswax as natural resources were used as drug release modifying polymers in varying ratios of 1:0, 0:1, and 1:1 respectively. All developed tablets were passed the uniformity of weight, friability, uniformity of thickness,

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19

Sajid Raza, Waqas Ahmad Khan, Nasir Khan, et al. "Etoricoxib-Loaded Transdermal Patches with Thiolated Pyrimidin Chitosan for Enhanced Delivery." Indus Journal of Bioscience Research 3, no. 6 (2025): 118–22. https://doi.org/10.70749/ijbr.v3i6.1571.

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This study focused on the development and evaluation of etoricoxib-loaded transdermal patches for sustained drug delivery to enhance bioavailability and patient compliance. The patches were formulated using polymeric matrices to achieve controlled drug release and improved skin permeability. Various physicochemical characterizations, including surface morphology, thickness, weight uniformity, folding endurance, tensile strength, and moisture content, were conducted to ensure uniformity and mechanical stability. In vitro drug release studies demonstrated a sustained release profile over 24 hour

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20

Huang, Zhonghui, Wannan Xiong, Kuriakose Kunnath, Sayani Bhaumik, and Rajesh N. Davé. "Improving blend content uniformity via dry particle coating of micronized drug powders." European Journal of Pharmaceutical Sciences 104 (June 2017): 344–55. http://dx.doi.org/10.1016/j.ejps.2017.04.012.

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21

Avinash, Bichave* Somesh Phate Vaishnavi Naik Anushka Gaikwad Lalit Choudhary Uttam Choudhary Shrutika Patil. "Evaluation Parameters For Mouth Dissolving Films." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 197–208. https://doi.org/10.5281/zenodo.12623624.

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Mouth dissolving films (MDFs) represent a significant advancement in drug delivery systems, providing an alternative to conventional tablets and capsules. This review explores the evaluation parameters critical to ensuring the quality, efficacy, and safety of MDFs. These parameters include disintegration time, weight variation, film thickness and uniformity, tensile strength, surface pH, drug content uniformity, and in vitro drug release. The emphasis is on understanding these parameters' roles and the advanced techniques used in their assessment. Regulatory considerations and challenges in fo

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22

Cruz, J., and M. Blanco. "Content uniformity studies in tablets by NIR-CI." Journal of Pharmaceutical and Biomedical Analysis 56, no. 2 (2011): 408–12. http://dx.doi.org/10.1016/j.jpba.2011.04.018.

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23

Bhowmik, Sreebash Chandra, Marzia Alam, and Md Saiful Islam Pathan. "Preparation and Evaluation of Palonosetron Hydrochloride Oral Thin Film." Bangladesh Pharmaceutical Journal 22, no. 2 (2019): 228–34. http://dx.doi.org/10.3329/bpj.v22i2.42316.

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The purpose of the current study was to develop a fast dissolving polymeric oral thin film containing palonosetron hydrochloride having good mechanical properties, fast disintegration, dissolution and good drug content uniformity. Solvent casting method was used to prepare the films. Compatibility between drugs and excipients were studied using FTIR and HPLC. Nine different formulations of film from F1 to F9 were prepared using different concentration of polymer A at drug-polymer A ratio (1:26), (1:28), (1:30), (1:32), (1:34), (1:36), (1:38), (1:40), (1:42) and at polymer A-plasticizer B of (6

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Peddapalli, Himabindu, Anjaneyulu Rajagoni, Preethi Pagilla, et al. "Design and Development of Transdermal Patches of Antipsychotic Drug: In vitro and Ex vivo Characterization." INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 5, no. 03 (2020): 45–53. http://dx.doi.org/10.21477/ijapsr.5.3.2.

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The purpose of the present research work was to design, assess, and estimate the developed transdermal matrix-type formulation comprising levosulpiride hydrochloride with the objective of enhancing the bioavailability and compliance of the patient. Transdermal films of levosulpiride were developed using a solvent casting method by hydroxypropyl methylcellulose (HPMC) E 15, Eudragit RL 100, and Eudragit RS100. In current research work, propylene glycol and oleic acid was used as plasticizer and permeation enhancers in different fractions. Among the batches, drug content uniformity with all form

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Stagner, W. C., B. J. Cerimele, and G. H. Fricke. "Content Uniformity: Separation and quantitation of sources of dose variation." Drug Development and Industrial Pharmacy 17, no. 2 (1991): 233–44. http://dx.doi.org/10.3109/03639049109043822.

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26

Bohidar, N. R., and Norman R. Bohidar. "Exact Power Function of Compendial Test Requirements for Content Uniformity." Drug Development and Industrial Pharmacy 20, no. 9 (1994): 1589–98. http://dx.doi.org/10.3109/03639049409050199.

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27

Vaishnavi, V. Gampawar* Shubham B. Dongare Satish P. Mohitkar Mahesh A. Hadke. "Custard Apple Leaves Hypoglycemic Jellies." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 93–100. https://doi.org/10.5281/zenodo.10777603.

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Hypoglycemic jelly formulations are more suitable for diabeties patients which offer rapid dissolution and absorption of drug there by early onset of action.The aim of this presented study is to introduce sugar free jelly as hypoglycemic agents. Preformulation organoleptic, weight variation, diameter & wideness drug content uniformity, disintegration, dissolution and stability study were conducted. The uv absorption studies were shown that drug absorption and drug content uniformity with respect to ug/ml. The concentration of gelling agent influence spreability gelling capacity. Jelly with

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28

Yuliani, Sri Hartati, Bernadetta Karina Sekar Maheswari, Melynia Sintha Dewi, Michael Raharja Gani, and Dina Christin Ayuning Putri. "Quality of Extemporaneous Preparation Containing Theophylline, Salbutamol Sulphate and Methylprednisolone." Journal of Pharmaceutical Sciences and Community 20, no. 2 (2023): 114–20. http://dx.doi.org/10.24071/jpsc.005316.

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Capsule preparations containing theophylline, salbutamol sulfate, and methylprednisolone were frequently prescribed in a private hospital in Yogyakarta. Theophylline is a narrow therapeutic index drug. Extemporaneous preparation products that contain narrow therapeutic index drugs have to meet the quality requirement. This study aimed to evaluate the quality of the capsule preparations. The sample was taken from a private hospital in Yogyakarta. The samples were assessed for physical characteristics, content uniformity, and chemical stability during storage. The result found that the physical

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P. Laxmi, G. Vijayalakshmi, and V. V. Basava Rao. "Formulation and evaluation of emulgels loaded with microspheres containing Baricitinib." World Journal of Biology Pharmacy and Health Sciences 18, no. 2 (2024): 157–67. http://dx.doi.org/10.30574/wjbphs.2024.18.2.0261.

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The main objective of the present research work was to formulate and evaluate transdermal gel loaded with microspheres of Baricitinib to increase bioavailability and to reduce the dosing frequency and to improve patient compliance. Gel loaded with microspheres of Baricitinib was prepared by taking different ratios and grades of Carbopol polymers. The prepared formulations (F1–F9) were evaluated for pre-formulation studies, percentage yield, particle size, content Uniformity, drug content entrapment efficiency and in vitro dissolution studies. The optimized gel loaded with microspheres of F8 fo

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Amadi, Rene Brown, and Sarah Vugigi. "Content Uniformity and Invitro Dissolution of Amlodipine Half Tablets." Kabarak Journal of Research & Innovation 14, no. 02 (2024): 212–19. http://dx.doi.org/10.58216/kjri.v14i02.467.

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Tablet splitting technique is a practice that is carried out in hospitals and community pharmacies. The aim is to achieve dose flexibility, reduce tablet size, ease swallowing, and save cost. This technique is prone to variation in the weight of split tablets, mass loss, and content uniformity. Its effectiveness is subject to the tablet characteristics, method of splitting, and patient’s knowledge and skill. This practice increases the risk of inaccurate dosing, uneven distribution of drug substances, and potential loss of efficacy or adverse effects. This study aimed to determine the effect o

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Vranić, Edina, and Alija Uzunović. "Study of the Applicabilty of Content Uniformity and Dissolution Variation Test on Ropinirole Hydrochloride Tablets." Bosnian Journal of Basic Medical Sciences 8, no. 2 (2008): 193–200. http://dx.doi.org/10.17305/bjbms.2008.2981.

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When considering single-dose preparations, it is fundamental that the patient receives in his individual dose an amount of drug close to that claimed on the label. Since drug content and content uniformity of single-dose preparations depend on a number of processes associated with their manufacture, it is obviously unrealistic to expect every unit of product to possess exactly the same amount of the active ingredient. For that reason, pharmacopeial standards and specifications have been established to provide limits for permissible variations in the amount of active ingredient of individual si

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Enéas, Paula Cristina Rezende, Renata Barbosa de Oliveira, and Gerson Antônio Pianetti. "Oxcarbazepine: validation and application of an analytical method." Brazilian Journal of Pharmaceutical Sciences 46, no. 2 (2010): 265–72. http://dx.doi.org/10.1590/s1984-82502010000200013.

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Oxcarbazepine (OXC) is an important anticonvulsant and mood stabilizing drug. A pharmacopoeial monograph for OXC is not yet available and therefore the development and validation of a new analytical method for quantification of this drug is essential. In the present study, a UV spectrophotometric method for the determination of OXC was developed. The various parameters, such as linearity, precision, accuracy and specificity, were studied according to International Conference on Harmonization Guidelines. Batches of 150 mg OXC capsules were prepared and analyzed using the validated UV method. Th

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Yusuf, F., S. J. Madu, A. O. Abdussalam, and A. S. Ibrahim. "Assessment of the Pharmaceutical Quality of some Brands of Omeprazole Capsules Marketed in Maiduguri Metropolis, Borno, Nigeria." Journal of Basic and Social Pharmacy Research 2, no. 1 (2021): 47–57. http://dx.doi.org/10.52968/27451085.

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BACKGROUND: The proliferation of counterfeit, substandard and inferior quality drugs is a major challenge in low- middle income countries like Nigeria where drug regulation and law enforcement are constrained by limited resources. OBJECTIVES: The aim of the study was to assess the quality parameters of some brands of Omeprazole capsules marketed in Maiduguri Metropolis, Borno State, Nigeria. METHODS: The uniformity of weight, disintegration test, content uniformity and dissolution rate test were the official tests carried out using Pharmacopoeial methods. Organoleptic tests and other non-offic

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S., Jyothi Sri* Dr. K. S. Murali Krishna D. Kusuma Ch. Uma Shankar. "FORMULATION AND IN-VITRO EVALUATION OF BENAZEPRIL MOUTH DISSOLVING FILMS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 552–60. https://doi.org/10.5281/zenodo.1162756.

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Oral route is most preferred route by medical practitioners and manufacturer due to highest acceptability of patients. But oral drug delivery systems still need some advancement to be made because of their some drawbacks related to particular class of patients which includes geriatric, pediatric and dysphasic patients associated with many medical conditions as they have difficulty in swallowing or chewing solid dosage forms. The aim of this is to highlight the potential role of fast dissolving drug delivery in achieving effective drug delivery of antihypertensive drug. It gives rapid absorptio

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Patil, Sudha, Santosh Karajgi, Channamallikarjun Vastrad, et al. "Formulation and characterization of transdermal drug delivery system comprising esomeprazole." BLDE University Journal of Health Sciences 10, no. 1 (2025): 40–45. https://doi.org/10.4103/bjhs.bjhs_62_24.

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Abstract: INTRODUCTION: Esomeprazole is an antacid belonging to the category of proton-pump inhibitors. OBJECTIVE: The key objective of the present effort was to formulate and analyze the transdermal patch of esomeprazole using polymers, permeability enhancers, as well as plasticizer agents by means of solvent casting technique. MATERIALS AND METHODS: Esomeprazole transdermal patches was prepared and evaluated for appearance, weight uniformity, thickness, drug content, folding endurance, X-ray diffraction (XRD) study, differential scanning calorimetry (DSC), investigation by scanning electron

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Elele, Ezinwa, Yueyang Shen, Rajyalakshmi Boppana, Afolawemi Afolabi, Ecevit Bilgili, and Boris Khusid. "Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles." Pharmaceutics 12, no. 11 (2020): 1034. http://dx.doi.org/10.3390/pharmaceutics12111034.

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We demonstrate the ability to fabricate dosage forms of a poorly water-soluble drug by using wet stirred media milling of a drug powder to produce an aqueous suspension of nanoparticles and then print it onto a porous biocompatible film. Contrary to conventional printing technologies, a deposited material is pulled out from the nozzle. This feature enables printing highly viscous materials with a precise control over the printed volume. Drug (griseofulvin) nanosuspensions prepared by wet media milling were printed onto porous hydroxypropyl methylcellulose films prepared by freeze-drying. The d

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Nkemakolam, Nwachukwu, Ugoeze Kenneth C, and Kennedy Emeka Oluigbo. "In Vitro Assessment of Some Brands of Fluconazole Capsules Marketed in Port Harcourt, Nigeria." Asian Journal of Pharmaceutical Research and Development 8, no. 3 (2020): 29–33. http://dx.doi.org/10.22270/ajprd.v8i3.722.

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Objectives: A routine in vitro pharmacopeial quality assessment of five brands of fluconazole capsules with label claims of 50.0 mg marketed in Port Harcourt, Nigeria was carried out to ascertain their consistencies. Methods: The brands were procured from various pharmacies in Port Harcourt and coded Fluco-A, Fluco-B, Fluco-C, Fluco-D and Fluco-E. Visual assessments of the samples were carried out besides in vitro quality considerations such as identification of the active pharmaceutical ingredient (API), capsules uniformity of weight, disintegration, an assay of the total content of flu

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Akshay Kumar S, Gowda D V, Sharadha M, and Famna Roohi N K. "Formulation and evaluation of third-generation Cefpodoxime proxetil as an Oro-dispersible tablets for treating infections." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 921–32. http://dx.doi.org/10.26452/ijrps.v11i1.1916.

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The main problems to humans include the infection caused in the respiratory tract and urinary tract, namely respiratory tract infection (RTI) and urinary tract infection (UTI). Cefpodoxime Proxetil drug is available in the market that has a problem with drug release profile and flows property. To overcome this problem, the compacted powder form made into a micro-ionized form for its better flow property and drug release by using a direct compression technique. The study was based on the aim to evaluate and formulate oro-dispersible tablets as an effective approach via orally for the treatment

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Torrado-Salmeron, Carlos, Almudena Laguna, Alicia Guillén, et al. "Tailoring Rational Manufacturing of Extemporaneous Compounding Oral Dosage Formulations with a Low Dose of Minoxidil." Pharmaceutics 14, no. 3 (2022): 658. http://dx.doi.org/10.3390/pharmaceutics14030658.

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Low amounts of minoxidil in oral dosage forms are commonly prescribed as anti-alopecic pharmacological treatments. Side effects are usually related to individual susceptibility. However, poor drug content and mass uniformity can lead to a potential risk of overdosing, and higher chances to experience side effects. The impacts of four formulation variables on drug content and mass pharmaceutical quality attributes were studied with an experimental design at two levels. The first variable (A) was the particle size of the direct compression microcrystalline cellulose (MCC) used as a diluent (Avic

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Singh, Sudarshan, S. S. Shyale, and H. G. Sandip. "Improved Dissolution Properties of Ketoconazole through Application of Liquisolid Techniques." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3053–59. http://dx.doi.org/10.37285/ijpsn.2015.8.4.9.

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In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Ketoconazole. The liquisolid tablets were formulated with liquid medications, namely Propylene Glycol (PG) drug concentrations, 60% w/w, 70% w/w and 80% w/w. Avicel pH102 was used as a carrier material, Aerosil 200 as a coating material and Sodium starch glycollate as a super-disintegrant. Quality control tests, such as uniformity of tablet weight, uniformity of drug content, tablet hardness, friability test, disintegration and dissolution tests were performed t

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P., Laxmi, Vijayalakshmi G., and V. Basava Rao V. "Formulation and evaluation of emulgels loaded with microspheres containing Baricitinib." World Journal of Biology Pharmacy and Health Sciences 18, no. 2 (2024): 157–67. https://doi.org/10.5281/zenodo.13734329.

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The main objective of the present research work was to formulate and evaluate transdermal gel loaded with microspheres of Baricitinib to increase bioavailability and to reduce the dosing frequency and to improve patient compliance. Gel loaded with microspheres of Baricitinib was prepared by taking different ratios and grades of Carbopol polymers. The prepared formulations (F1–F9) were evaluated for pre-formulation studies, percentage yield, particle size, content Uniformity, drug content entrapment efficiency and <em>in vitro</em> dissolution studies. The optimized gel loaded w

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Pathak, Sudhakar, Harish Pandey, and Sunil Kumar Shah. "Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 298–309. http://dx.doi.org/10.22270/jddt.v9i4-s.3322.

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Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The purpose of this research was to develop and

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van der Zanden, Tjitske M., Saskia N. de Wildt, Yves Liem, Martin Offringa, and Matthijs de Hoog. "Developing a paediatric drug formulary for the Netherlands." Archives of Disease in Childhood 102, no. 4 (2016): 357–61. http://dx.doi.org/10.1136/archdischild-2016-311674.

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As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical experience and consensus. This has clarified the scientific grounds of drug use for children and encouraged uniformity in prescribing habits in the Netherlands. The developed framework and the current content of the Dutch Paediatric Formulary could be used as basis for similar initiatives worldwide, pref

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Thipe, Sohan Sukaldas, Amol V. Sawale, Shraddha Dilip Muneshwar, Shiwani A. Gulhane, and Sakshi S. Gahukar. "Formulation and Evaluation of Buccoadhesive Tablet of Verapamil Hydrochloride for the Treatment of Hypertension." Journal of Drug Delivery and Therapeutics 13, no. 7 (2023): 15–21. http://dx.doi.org/10.22270/jddt.v13i7.6122.

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The creation and assessment of buccoadhesive tablets of verapamil hydrochloride were the study's primary goals. Blood pushing excessively hard against the arterial wall is referred to as hypertension. Typically, hypertension is characterized by blood pressure readings over 140/90; readings over 180/120 are regarded as severe hypertension. Verapamil is used to manage angina (chest pain) and treat excessive blood pressure. Verapamil belongs to the category of drugs known as calcium channel blockers. In order to save the heart from having to pump as hard, it relaxes the blood artery. Additionally

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Lai, Jin W. "Analysis of Content Uniformity Data of Tablets with two Active Ingredients." Drug Development and Industrial Pharmacy 20, no. 3 (1994): 405–8. http://dx.doi.org/10.3109/03639049409050193.

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Banov, Daniel, Yi Liu, Kendice Ip, et al. "Analysis of the Physical Characteristics of an Anhydrous Vehicle for Compounded Pediatric Oral Liquids." Pharmaceutics 15, no. 11 (2023): 2642. http://dx.doi.org/10.3390/pharmaceutics15112642.

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The paucity of suitable drug formulations for pediatric patients generates a need for customized, compounded medications. This research study was set out to comprehensively analyze the physical properties of the new, proprietary anhydrous oral vehicle SuspendIt® Anhydrous, which was designed for compounding pediatric oral liquids. A wide range of tests was used, including sedimentation volume, viscosity, droplet size after dispersion in simulated gastric fluid, microscopic examination and content uniformity measurements to evaluate the properties of the anhydrous vehicle. The results showed th

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Dileep, Kumar Awasthi, B. Puranik Sangamesh, Saraswat Rohit, Kumar Jhajharia Mahesh, and Sharma Prashant. "Design, Formulation Development and Evaluation of Matrix Tablet Containing Labetalol HCL." International Journal of Engineering Research & Science 6, no. 8 (2020): 05–14. https://doi.org/10.5281/zenodo.4090901.

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<strong>Abstract</strong><strong>—</strong> The objective of present work was to design and develop sustained release matrix tablets of anti-hypertensive drug Labetalol hydrochloride. Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide used as a rate retarding polymer. Whereas Polyvinyl Pyrrolidone and Microcrystalline cellulose are used as granulating agent and diluent. The influence of variable concentration of polymers on the release rate of drug was investigated. The results of the present work point out that the rate of Labetalol hydrochlorid

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Centkowska, Katarzyna, Elżbieta Ławrecka, and Malgorzata Sznitowska. "Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties." Pharmaceutics 12, no. 3 (2020): 250. http://dx.doi.org/10.3390/pharmaceutics12030250.

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The production of orodispersible films (ODFs) with suspended insoluble drug substances is still a challenge, mainly due to the difficulty associated with achieving a proper homogeneity and mechanical properties of the films. Hypromellose (HPMC) and a mixture of polyvinyl alcohol (AP) and povidone (PVP) were compared in terms of their suitability for ODFs incorporating suspended micronized loratadine (LO) in a concentration range of 10%–40%. In a planetary mixer (Thinky), a uniform dispersion of LO in an aqueous viscous casting solution was obtained. The suspended LO particles caused dose-depen

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Ketan, Patil* Shyam Patil Lokesh Chaudhari Divyesh Gahivad Mohammad Awais Habib Shaikh Nazeer Ahmad. "Orally Dissolving Strips: A Novel Formulation for Quick Drug Absorption." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 947–72. https://doi.org/10.5281/zenodo.15179847.

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The present study focuses on the formulation and evaluation of orally dissolving strips (ODS) of paracetamol to enhance patient compliance and provide rapid drug release. The strips were prepared using a two-phase method with hydroxypropyl methylcellulose (HPMC) as the film-forming polymer, glycerin as a plasticizer, and amaranth as a coloring agent. The formulated ODS were subjected to various physicochemical evaluations, including thickness measurement, drug content uniformity, disintegration time, and dissolution studies, to ensure compliance with pharmacopeial standards. Thickness analysis

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K., Muniraja Lakshmi N. Deekshitha Reddy*. "A Review On Suppositories." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 668–75. https://doi.org/10.5281/zenodo.10701894.

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Suppositories are pharmaceutical dosage forms that hold a crucial place in the realm of drug delivery. Suppositories are the dosage form inserted into body cavity, mainly rectum and vagina to deliver the drug into the systemic circulation. Suppositories can be taken by patients who are unable to take medicine orally due to nausea and vomiting, and neurological disorder. Suppositories are used over other dosage form because it comes in different shapes and sizes. Suppositories are one of the very feasible modes of administration for medication. It can be prepared by using various bases like coc

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