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Journal articles on the topic 'Drug delivery. Abbreviation: Orodispersible films'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Bhavesh, Machhi* Aathira Chandran Divyanka Bodas Chandrakant Wadile Pankaj Mandpe. "Recent Advancement: 3D-Printed Orodispersible Film as Pharmaceutical Dosage Forms for Paediatric Patients." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 1324–38. https://doi.org/10.5281/zenodo.14673092.

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Traditional drug delivery systems are often unsuitable for paediatric patients due to their unique developmental stages and specific dosing requirements are distinct from those of other groups within the population. Oral delivery is recognized as the most user-friendly and popular method in therapeutic practices due to its safety, high patient compliance, ease of administration, affordable price, and flexibility. The challenge of medication adherence is increasingly recognized as a critical public health issue, with poor adherence to treatment linked to negative health consequences and higher

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2

HUSSAIN, ABRAR, and ZULCAIF AHMAD. "A REVIEW OF ORODISPERSIBLE FILMS FOR ENHANCED DRUG DELIVERY." Cellulose Chemistry and Technology 59, no. 1-2 (2025): 1–10. https://doi.org/10.35812/cellulosechemtechnol.2025.59.01.

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This review article provides a comprehensive overview of orodispersible films as a versatile drug delivery system. Orodispersible films, also known as buccal films, offer several advantages over traditional oral dosage forms, particularly for patients who have difficulty swallowing, such as children, the elderly, and those with dysphagia. These films rapidly disintegrate in the oral cavity, allowing for easy administration and improved patient compliance. The review discusses the types of buccal films, including flash release, mucoadhesive melt-away, and mucoadhesive sustained-release films, a

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3

Hoffmann, Eva Maria, Armin Breitenbach, and Jörg Breitkreutz. "Advances in orodispersible films for drug delivery." Expert Opinion on Drug Delivery 8, no. 3 (2011): 299–316. http://dx.doi.org/10.1517/17425247.2011.553217.

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Motiwale, Abhijeet, and Narendra Pratap Singh Sengar. "Design, Optimization and Characterization of Mouth Dissolving Orodispersible Films of Irbesartan and Triamterene." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–05. https://doi.org/10.25258/ijddt.15.2.53.

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Mouth Dissolving Orodispersible Films (ODFs) are thin, flexible films designed to dissolve quickly in the mouth without the need for water. They are a convenient and patient-friendly drug delivery system, especially useful for pediatric, geriatric, and pediatric patients or those who have difficulty swallowing tablets or capsules. Mouth Dissolving Orodispersible Films represent a promising drug delivery platform that combines convenience, rapid action, and improved compliance, making them increasingly popular in modern pharmaceutical formulations. In the present work Mouth Dissolving Orodisper

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Jacob, Shery, Sai H. S. Boddu, Richie Bhandare, Samiullah Shabbir Ahmad, and Anroop B. Nair. "Orodispersible Films: Current Innovations and Emerging Trends." Pharmaceutics 15, no. 12 (2023): 2753. http://dx.doi.org/10.3390/pharmaceutics15122753.

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Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery system. Recent advancements, including the detailed exploration of formulation components, such as polymers and plasticizers, are briefed. The review highlights the versatility of preparation methods, particularly the solvent-casting production process, and novel 3D printing techniques that bring inherent flexibi

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Scarpa, Mariagiovanna, Sven Stegemann, Wen-Kai Hsiao, et al. "Orodispersible films: Towards drug delivery in special populations." International Journal of Pharmaceutics 523, no. 1 (2017): 327–35. http://dx.doi.org/10.1016/j.ijpharm.2017.03.018.

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Iqbal, Sonia, Hanasul Hanan, Afshan Maqbool, and Nasra Munawar. "A review on orodispersible drug delivery system." Journal of Contemporary Pharmacy 7, no. 1 (2023): 24–31. http://dx.doi.org/10.56770/jcp2023714.

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The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary s

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Iqbal, Sonia, Hanasul Hanan, Afshan Maqbool, and Nasra Munawar. "A review on orodispersible drug delivery system." Journal of Contemporary Pharmacy 7, no. 1 (2023): 24–31. http://dx.doi.org/10.56770/jcp.2023714.

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The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary s

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9

Gupta, Suresh, Tegginamath Pramod Kumar, and Devegowda Vishakante Gowda. "Patent Perspective on Orodispersible Films." Recent Patents on Drug Delivery & Formulation 14, no. 2 (2020): 88–97. http://dx.doi.org/10.2174/1872211314666200904104022.

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: The traditional oral dosage forms (tablets, capsules, syrups, and elixirs) suffer from various disadvantages. They are pretty challenging to administer to patients with dysphagia, mucositis, and vomiting tendency. Therefore, gaining patient compliance using conventional dosage forms is highly cumbersome. One of the most transformative and innovative approaches to overcome such challenges is Orodispersible Films, a Novel Drug Delivery System. They are easy to consume, no need to chew or swallow and they do not even require water for consumption. Therefore, several drugs have been converted in

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10

Vrushali, S. Gangurde*1 Pradnya H. Kapse2 Khanderao Jadhav3 Rishikesh Bachhav4. "Mouth Dissolving Films: A novel approach in oral drug delivery." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 1223–36. https://doi.org/10.5281/zenodo.11080675.

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The most sophisticated oral solid dose forms are mouth dissolving or orodispersible films because of their versatility and ease of usage. The Mouth Dissolving film is a solid oral dosage form that, when placed in the mouth without water or chewing, dissolves and decomposes rapidly. By avoiding first pass metabolism, the drug's bioavailability is increased when taken in this dosage form. Additionally, orodispersible films may result in a lower dosage, a quicker onset of action, and no choking hazards. Solvent casting and semisolid casting methods are used to laminate API chemicals that mask fla

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Olechno, Katarzyna, Anna Basa, and Katarzyna Winnicka. "“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films." Materials 14, no. 17 (2021): 4872. http://dx.doi.org/10.3390/ma14174872.

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Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films

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Loveleen, Arora* Tanushree Chakraborty. "A REVIEW ON NEW GENERATION ORODISPERSIBLE FILMS AND ITS NOVEL APPROACHES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7451–70. https://doi.org/10.5281/zenodo.1007035.

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The oral route is the safest and marketable route for the administration of therapeutic agents for the use of human as well as the veterinary. Pharmaceutical scientists throughout the world are inspecting Orodispersible films (ODFs) as an innovative drug delivery tool. Orodispersible films are now a days are recognized as an alternative approach to conventional dosage form. These thin oral films containing API have ability to releases the drug quickly for both systemic and local action via oral or, sublingual routes. The design of an effective orodispersible film requires an encyclopedic knowl

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Ruchi Sharma, Deepika Joshi, Bhavana Singh, and Nidhi Semwal. "A review on orodispersible film a novel approach of drug delivery system." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 001–11. http://dx.doi.org/10.30574/wjbphs.2022.12.1.0130.

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The effective distribution of the drug to the body is the main objective of every drug delivery mechanism, but patient compliance must also be taken into consideration. Fasat-dissolving drug delivery technologies, such Or dispersible Films (ODFs), make it simple to administer medication to the general public as well as to certain demographic groups with swallowing issues, like youngsters and the elderly. ODFs are cutting-edge dosage forms that dissolve and disintegrate inside the mouth. Intra-oral absorption enables quick action and aids in avoiding first-pass effects, reducing the unit dose n

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Ruchi, Sharma, Joshi Deepika, Singh Bhavana, and Semwal Nidhi. "A review on orodispersible film a novel approach of drug delivery system." World Journal of Biology Pharmacy and Health Sciences 12, no. 1 (2022): 001–11. https://doi.org/10.5281/zenodo.7602023.

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The effective distribution of the drug to the body is the main objective of every drug delivery mechanism, but patient compliance must also be taken into consideration. Fasat-dissolving drug delivery technologies, such Or dispersible Films (ODFs), make it simple to administer medication to the general public as well as to certain demographic groups with swallowing issues, like youngsters and the elderly. ODFs are cutting-edge dosage forms that dissolve and disintegrate inside the mouth. Intra-oral absorption enables quick action and aids in avoiding first-pass effects, reducing the unit dose n

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15

Salawi, Ahmad. "An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review." Pharmaceuticals 15, no. 7 (2022): 844. http://dx.doi.org/10.3390/ph15070844.

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Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward novel drug delivery systems. This delivery system helps to achieve drug response by local and systemic action through different routes. This novel approach of preparing orodispersible films (ODFs) provides benefits to paediatric, geriatric, and bedridden patients. This review paper aims to provide de

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Meloni, Valentina, Laura Halstenberg, Lena Mareczek, et al. "Exploring Orodispersible Films Containing the Proteolysis Targeting Chimera ARV-110 in Hot Melt Extrusion and Solvent Casting Using Polyvinyl Alcohol." Pharmaceutics 16, no. 12 (2024): 1499. http://dx.doi.org/10.3390/pharmaceutics16121499.

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Background/Objectives: This project aims to provide valuable insights into the formulation of orodispersible films (ODFs) for the delivery of PROTAC ARV-110. The primary objective of this drug delivery formulation is to enhance the solubility of PROTAC ARV-110, which faces significant challenges due to the low solubility of this active pharmaceutical ingredient, as it belongs to a molecular class that is considered to exceed the “Rule of Five”. Methods: We employed the concept of developing a rapidly disintegrating ODF to enhance the solubility of PROTAC ARV-110, utilizing polyvinyl alcohol as

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Wadher, Kamlesh J., Charvi J. Kubde, Swati D. Malkote, Manasi S. Thakre, Chetna J. Shelote, and Milind J. Umekar. "Formulation and Characterization of Montelukast Sodium Mouth Dissolving Film Using Cress Seed Mucilage." Journal of Drug Delivery and Therapeutics 13, no. 2 (2023): 16–20. http://dx.doi.org/10.22270/jddt.v13i2.5891.

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There is a rising interest in the development of orodispersible films (ODFs) as an alternative to fast dissolving tablets which is attributed to their faster dissolution rate, higher durability, and better patient compliance. Owing to its rheological and also various functional properties, many researchers tried to discover some of the pharmaceutical applications of L. sativum in the development of various dosage forms, in addition to its therapeutic studies, such as binding, dissolving, gelling and sustained release dosage form. The fast-dissolving oral film of the Montelukast sodium by using

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18

Bácskay, Ildikó, Zoltán Ujhelyi, Pálma Fehér, and Petra Arany. "The Evolution of the 3D-Printed Drug Delivery Systems: A Review." Pharmaceutics 14, no. 7 (2022): 1312. http://dx.doi.org/10.3390/pharmaceutics14071312.

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Since the appearance of the 3D printing in the 1980s it has revolutionized many research fields including the pharmaceutical industry. The main goal is to manufacture complex, personalized products in a low-cost manufacturing process on-demand. In the last few decades, 3D printing has attracted the attention of numerous research groups for the manufacturing of different drug delivery systems. Since the 2015 approval of the first 3D-printed drug product, the number of publications has multiplied. In our review, we focused on summarizing the evolution of the produced drug delivery systems in the

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19

Wasilewska, Katarzyna, and Katarzyna Winnicka. "How to assess orodispersible film quality? A review of applied methods and their modifications." Acta Pharmaceutica 69, no. 2 (2019): 155–76. http://dx.doi.org/10.2478/acph-2019-0018.

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Abstract In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture of orodispersible films (ODFs), which is an upcoming area of interest in drug delivery. They are defined as polymer thin films that disintegrate in the oral cavity within seconds, without drinking water or chewing, and eliminate the risk of choking. Gaining special usefulness in therapies

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20

Olechno, Katarzyna, Bartosz Maciejewski, Klaudia Głowacz, et al. "Orodispersible Films with Rupatadine Fumarate Enclosed in Ethylcellulose Microparticles as Drug Delivery Platform with Taste-Masking Effect." Materials 15, no. 6 (2022): 2126. http://dx.doi.org/10.3390/ma15062126.

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Orally disintegrating (orodispersible) films provide a versatile tool for drug administration, especially in the pediatric and geriatric population, since they reduce the risk of choking and do not necessitate drinking water during application. By considering their direct contact with the taste buds, palatability is an influential aspect related to patient compliance. The microparticles based on taste-masking polymers containing drugs enclosed inside effectively mask the unpleasant taste of medicines. Ethylcellulose is a hydrophobic polymer widely used as a taste-masking material. Rupatadine f

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Vlad, Robert-Alexandru, Andrada Pintea, Cezara Pintea, et al. "Hydroxypropyl Methylcellulose—A Key Excipient in Pharmaceutical Drug Delivery Systems." Pharmaceutics 17, no. 6 (2025): 784. https://doi.org/10.3390/pharmaceutics17060784.

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Hydroxypropyl methylcellulose (Hypromellose, HPMC) is a well-known excipient used in the pharmaceutical and nutraceutical fields due to its versatile physicochemical properties. HPMC (derived from cellulose and obtained through etherification) varies in polymerization degree and viscosity, factors that both influence its functional applications. Usually, an increased polymerization degree implies a higher viscosity, depending also on the amount of polymer used. Hypromellose plays a crucial role in solid dosage forms, serving as a binder in the case of controlled-release tablets, a film-forming

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Jadach, Barbara, Martyna Misek, and Jan Ferlak. "Comparison of Hydroxypropyl Methylcellulose and Alginate Gel Films with Meloxicam as Fast Orodispersible Drug Delivery." Gels 9, no. 9 (2023): 687. http://dx.doi.org/10.3390/gels9090687.

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The aim of the study was the preparation and comparison of two types of orodispersible gel films (ODF) by the solvent casting method. Natural polymers: sodium alginate (ALG) or hydroxypropyl methylcellulose (HPMC) were used as the gel film formers, and Kollidon or microcrystalline cellulose was used as the disintegrant. Meloxicam (MLX), the drug used to treat rheumatic diseases for children and adults, was proposed as the active pharmaceutical ingredient (API). The influence of the polymer and disintegrant on the properties of ODF was investigated. The evaluation of prepared gel films was base

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Ozon, Emma Adriana, Iulian Sarbu, Violeta Popovici, et al. "Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview." Processes 11, no. 9 (2023): 2628. http://dx.doi.org/10.3390/pr11092628.

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The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation str

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Ferlak, Jan, Weronika Guzenda, and Tomasz Osmałek. "Orodispersible Films—Current State of the Art, Limitations, Advances and Future Perspectives." Pharmaceutics 15, no. 2 (2023): 361. http://dx.doi.org/10.3390/pharmaceutics15020361.

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Orodispersible Films (ODFs) are drug delivery systems manufactured with a wide range of methods on a big scale or for customized medicines and small-scale pharmacy. Both ODFs and their fabrication methods have certain limitations. Many pharmaceutical companies and academic research centers across the world cooperate in order to cope with these issues and also to find new formulations for a wide array of APIs what could make their work profitable for them and beneficial for patients as well. The number of pending patent applications and granted patents with their innovative approaches makes the

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Prajapati, Vinitbhai*1 Himanshu Sharma2 Sagar Patra3 Sahilahmad Makarani3 Mahendrakumar Dubey1. "A Contemporary Approach to The Medicate Conveyane Through Orodispersible Tablets." International Journal of Scientific Research and Technology 1, no. 12 (2024): 29–40. https://doi.org/10.5281/zenodo.14285188.

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The development of dosage forms that are easy to manufacture and administer, as well as rapid release and increased bioavailability, have led to new drug delivery systems. To achieve the desired result, drugs must be delivered to the site of action at a speed and concentration that maximizes therapeutic benefits and minimizes side effects. The most popular and efficient way of drug administration is oral. Recently, many medicinal products have been released in the market. The use of lyophilizers and oral tablets or films have expanded treatment options. Both children and adults can benefit fro

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Shubha, P., K. Namratha, C. S. Vicas, et al. "Orodispersible Films of Punicalagin from Pomegranate Peel-A Novel Drug Delivery System for Dental Caries Prevention." Materials Focus 5, no. 1 (2016): 24–30. http://dx.doi.org/10.1166/mat.2016.1288.

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Sushir, Chetan, Vaishali Kilor, and Ashika Rewatkar. "Pediatric Drug Development Process: A Review." Asian Journal of Pediatric Research 12, no. 2 (2023): 23–34. http://dx.doi.org/10.9734/ajpr/2023/v12i2238.

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This review includes New Formulation approaches to improve Pediatric compliance such as Mini tablets, 3D printing, Orodispersible films, Chewable tablets. Various strategies to improve patient adherence such as ‘nipple shield’ delivery system, dry solid formulations to be converted to liquid at the point of administration, pill swallowing cups, Medicated dosing straw. It is important to formulate pediatric medicines that are tailored to a child’s age, size, physiological condition, and treatment requirements. Legislations for pediatric formulation to ensure that products to treat pediatric pat

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Low, Ariana, Si Ling Kok, Yuetmei Khong, Sui Yung Chan, and Rajeev Gokhale. "Pharmaceutics, Drug Delivery and Pharmaceutical Technology: A New Test Unit for Disintegration End-Point Determination of Orodispersible Films." Journal of Pharmaceutical Sciences 104, no. 11 (2015): 3893–903. http://dx.doi.org/10.1002/jps.24609.

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Cho, Hui-Won, Seung-Hoon Baek, Beom-Jin Lee, and Hyo-Eon Jin. "Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing." Pharmaceutics 12, no. 8 (2020): 692. http://dx.doi.org/10.3390/pharmaceutics12080692.

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Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process. Three-dimensional (3D) printing based on hot-melt pneumatic extrusion (HMPE) is a simplified method for producing ASDs. Unlike general 3D printing, printlet extrusion is possible without the preparation of drug-loaded filaments. By heating powder blends, direct fused deposition modeling (FDM) printing through a nozzle is possible, and this step produces ASDs of drugs. In this study, w

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Gupta, Maram, Devegowda Gowda, Tegginamath Kumar, and Jessica Rosenholm. "A Comprehensive Review of Patented Technologies to Fabricate Orodispersible Films: Proof of Patent Analysis (2000–2020)." Pharmaceutics 14, no. 4 (2022): 820. http://dx.doi.org/10.3390/pharmaceutics14040820.

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Orodispersible films (ODFs)are ultra-thin, stamp-sized, rapidly disintegrating, and attractive oral drug delivery dosage forms best suited for the pediatric and geriatric patient populations. They can be fabricated by different techniques, but the most popular, simple, and industrially applicable technique is the solvent casting method (SCM). In addition, they can also be fabricated by extrusion, printing, electrospinning, and by a combination of these technologies (e.g., SCM + printing). The present review is aimed to provide a comprehensive overview of patented technologies of the last two d

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Panraksa, Pattaraporn, Sheng Qi, Suruk Udomsom, et al. "Characterization of Hydrophilic Polymers as a Syringe Extrusion 3D Printing Material for Orodispersible Film." Polymers 13, no. 20 (2021): 3454. http://dx.doi.org/10.3390/polym13203454.

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The application of hydrophilic polymers in designing and three-dimensional (3D) printing of pharmaceutical products in various dosage forms has recently been paid much attention. Use of hydrophilic polymers and syringe extrusion 3D printing technology in the fabrication of orodispersible films (ODFs) might hold great potential in rapid drug delivery, personalized medicine, and manufacturing time savings. In this study, the feasibility of 3D-printed ODFs fabrication through a syringe extrusion 3D printing technique and using five different hydrophilic polymers (e.g., hydroxypropyl methylcellulo

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Uhljar, Luca Éva, Areen Alshweiat, Gábor Katona, et al. "Comparison of Nozzle-Based and Nozzle-Free Electrospinning for Preparation of Fast-Dissolving Nanofibers Loaded with Ciprofloxacin." Pharmaceutics 14, no. 8 (2022): 1559. http://dx.doi.org/10.3390/pharmaceutics14081559.

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The study aimed to prepare ciprofloxacin-loaded polyvinylpyrrolidone electrospun nanofibers for oral drug delivery, using a conventional nozzle-based and a lab-built nozzle-free electrospinning equipment. To produce nanofibers, electrospinning is the process most often used. However, from the industry’s point of view, conventional electrospinning does not have sufficiently high productivity. By omitting the nozzle, productivity can be increased, and so the development of nozzle-free processes is worthwhile. In this study, a solution of ciprofloxacin and polyvinylpyrrolidone was electrospun und

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Racaniello, G. F., D. Mathiron, S. Rigaud та ін. "Development of midazolam/γ-cyclodextrin orodispersible films using direct powder extrusion 3D printing: A novel approach to inclusion complex and drug delivery systems formulation". Carbohydrate Polymers 368 (листопад 2025): 124134. https://doi.org/10.1016/j.carbpol.2025.124134.

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Paipa-Jabre-Cantu, Samir I., Marisela Rodriguez-Salvador, and Pedro F. Castillo-Valdez. "Revealing Three-Dimensional Printing Technology Advances for Oral Drug Delivery: Application to Central-Nervous-System-Related Diseases." Pharmaceutics 17, no. 4 (2025): 445. https://doi.org/10.3390/pharmaceutics17040445.

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Background/Objectives. Central nervous system (CNS)-related diseases such as Alzheimer’s and Parkinson’s, Attention Deficit Hyperactive Disorder (ADHD), stroke, epilepsy, and migraines are leading causes of morbidity and disability worldwide. New solutions for drug delivery are increasingly needed. In this context, three-dimensional (3D) printing technology has introduced innovative alternatives to produce more efficient medicines with diverse features, patterns, and consistencies, particularly oral medications. Even though research in this area is growing rapidly, no study has thoroughly anal

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-, Vaishnavi Karbhari Mokate, Kalyanee Vijay Gavande -, Amol Navnath Khedkar -, and Mahesh Bhagwan Kolpe -. "Encyclopedic Overview on Orodispersible Films." International Journal For Multidisciplinary Research 5, no. 6 (2023). http://dx.doi.org/10.36948/ijfmr.2023.v05i06.8625.

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Fast-dissolving drug delivery systems have gained attention and acceptance recently as innovative drug delivery methods that seek to improve patient compliance while improving the safety and effectiveness of a therapeutic molecule by preparing it for administration in a traditional oral dosage form. Some businesses unveiled more durable fast-dissolving medication delivery systems. The tongue is either the floor or the top of the film. This film instantly dissolves when applied to the tongue, releasing the medication, which then dissolves in saliva. The saliva travels down into the stomach, whe

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Kamboj, Sweta, Rohit Dutt, and Rohit Kamboj. "Orodispersible thin films: A Hodiernal Perspective in Drug Delivery System." Research Journal of Pharmacy and Technology, January 25, 2022, 447–57. http://dx.doi.org/10.52711/0974-360x.2022.00074.

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Undoubtedly that the ongoing epoch of pharmaceutical research has been focusing on the productive technological evolution of the drug delivery system so that the effectiveness appropriate to drug and patient’s sustainability can be strengthened. As determination and generation of present day chemical agents or substances are complex, expensive, and time-consuming procedure, so neoteric trends are reposition towards the drafting and advancing the inventive drug delivery systems for existing drugs. Among various pharmaceutical forms, orodispersible thin films have gained more interest from drug

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N., Sumiya* K. Vanaja A. Deevan Paul Chitra Prasanthi K. Thyagaraju A. Murali Krishna. "MODELING OF DRUG DELIVERY THROUGH THIN LAYER POLYMERIC FILMS IN DOSAGE FORM TECHNOLOGIES: RECENT DEVELOPMENTS AND FUTURE CHALLENGES." October 31, 2018. https://doi.org/10.5281/zenodo.2530519.

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Orodispersible films have been identified as an alternative approach to conventional dosage forms. The films are considered to be convenient to swallow, self-administrable, and fast dissolving dosage form, out of that it has a versatile platform for drug delivery. This delivery system has been used for both systemic and local action through several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The sublingual and buccal delivery of a drug through thin film has the potential to improve the onset of action, lower the dosing, and enhance the efficacy and safety profile o

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Singh Rawat, Balwant, Ashutosh Badola, Satyendra Kumar Rajput, et al. "A Review on Orodispersible Film-based Novel Drug Delivery System." Research Journal of Pharmacy and Technology, July 24, 2024, 3480–88. http://dx.doi.org/10.52711/0974-360x.2024.00544.

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Orally-dissolving films, sometimes called orodispersible films (ODF), are a type of oral solid dosage form that dissolves quickly in the mouth without chewing or drinking liquids. These innovative pharmaceutical formulations have attracted a great deal of attention due to their exceptional ability to improve patient compliance and convenience, especially in children, the elderly, and patients with dysphagia, who may have trouble swallowing conventional solid dosage forms. The main goal of orodispersible films is to provide a rapid and effective drug delivery through the oral mucosa. This metho

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Loveleen, Arora* Tanushree Chakraborty. "A REVIEW ON NEW GENERATION ORODISPERSIBLE FILMS AND ITS NOVEL APPROACHES." January 31, 2017. https://doi.org/10.5281/zenodo.2381845.

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The oral route is the safest and marketable route for the administration of therapeutic agents for the use of human as well as the veterinary. Pharmaceutical scientists throughout the world are inspecting Orodispersible films (ODFs) as an innovative drug delivery tool. Orodispersible films are now a days are recognized as an alternative approach to conventional dosage form. These thin oral films containing API have ability to releases the drug quickly for both systemic and local action via oral or, sublingual routes. The design of an effective orodispersible film requires an encyclopedic knowl

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I S, Anjana, Sujith Varma K, Aparna George, and Anupriya A B. "Orodispersible Film, A new concept in Drug Delivery Technology." Research Journal of Pharmacy and Technology, May 15, 2024, 2391–97. http://dx.doi.org/10.52711/0974-360x.2024.00374.

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In recent years there has been a trend towards creating innovative and patient friendly drug delivery systems which are tailored to each consumer for ensuring drug safety, stability and acceptability. The creation of orodispersible films (ODFs) offers increased comfort and flexibility making it one of the most innovative and promising strategy in drug safety. The film dissolve in oral cavity in few seconds when mixed with saliva. The ODFs can taken with ease and does not require water for administration. ODFs are gaining popularity due to its advantages over other orally administered dosage fo

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P., Hyma B. Revathi* K. Pranitha. "FORMULATION AND EVALUATION OF ORODISPERSIBLE FILMS OF ACECLOFENAC." September 30, 2021. https://doi.org/10.5281/zenodo.5541193.

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The present work was aimed to formulate Oro Dispersible Films (ODF) of Aceclofenac with improved solubility and patient compliance. ODFs or fast dissolving films are the new dosage formulation which are becoming most preferred drug delivery systems. ODFs have advantages over other formulations like improved solubility of poorly soluble drugs, enhanced patient compliance, instant release of drug, avoiding hepatic first pass effect, etc. Aceclofenac is one of the poorly water-soluble drug which is used as NSAID having analgesic and anti-inflammatory actions. Hence Aceclofenac was used in the pre

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Chacko, Indhu Annie, Gayathri Ramachandran, and M. S. Sudheesh. "Unmet technological demands in orodispersible films for age-appropriate paediatric drug delivery." Drug Delivery and Translational Research, November 13, 2023. http://dx.doi.org/10.1007/s13346-023-01451-3.

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Singh, Navdeep, Sweta Sweta, and Shammy Jindal. "A Concise Overview on Orodispersible Film along with their Formulation and Characterization Technique’s." Research Journal of Pharmaceutical Dosage Forms and Technology, February 22, 2024, 98–106. http://dx.doi.org/10.52711/0975-4377.2024.00016.

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Orally fast-dissolving medicine delivery techniques are increasingly common at present. Due to the desire for these delivery systems, oro-dispersible film (ODF) was recently introduced for the delivery of medicines via the oral route. Most of drugs are delivering through oral route in the form of tablets, capsules and liquids, because they are simple to make and have a greater level of patient compliance. But these conventional dosage forms have many problems including big size of dosage form, and fear of chocking. Oral rapid disintegrating/oro-dispersible drug delivery systems were created to

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Morath, B., S. Sauer, M. Zaradzki, and A. H. Wagner. "TEMPORARY REMOVAL: Orodispersible films – Recent developments and new applications in drug delivery and therapy." Biochemical Pharmacology, April 2022, 115036. http://dx.doi.org/10.1016/j.bcp.2022.115036.

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Hussain, Abrar, Zulcaif Ahmad, Asif Mahmood, et al. "Nystatin, Aspirin and Lidocaine Containing Orodispersible Films for Pronounced Drug Delivery: Development and Characterization." BioNanoScience, July 3, 2024. http://dx.doi.org/10.1007/s12668-024-01511-z.

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Polonini, Hudson, Bruna Marianni, Emanuel da Silva Rovai, Maria Aparecida Neves Jardini, Camilla Magnoni Moretto Nunes, and Carlos Rocha Oliveira. "Evaluation of In Vitro Toxicity of OrPhyllo™, a New Vehicle to Produce Orodispersible Films." International Journal of Toxicology, May 6, 2025. https://doi.org/10.1177/10915818251340384.

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Orodispersible films (ODFs) are advanced drug delivery systems that consist of thin, mechanically robust polymeric films designed to dissolve or disintegrate quickly in the oral cavity, facilitating local and systemic drug administration. Orphyllo™ is a novel ODF vehicle developed to enhance the stability and delivery efficiency of active pharmaceutical ingredients. This study aimed to assess the safety profile of Orphyllo™ through a comprehensive evaluation of its cytotoxicity and genotoxicity on human oral mucosa cell lines. The cytotoxicity was evaluated using (3-(4,5-Dimethylthiazol-2-yl)-

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BADEKAR, RUCHITA, VISHAL BODKE, BHARAT W. TEKADE, and SWAPNIL D. PHALAK. "AN OVERVIEW ON ORAL THIN FILMS–METHODOLOGY, CHARACTERIZATION AND CURRENT APPROACH." International Journal of Pharmacy and Pharmaceutical Sciences, April 1, 2024, 1–10. http://dx.doi.org/10.22159/ijpps.2024v16i4.50386.

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The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of th

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Dziemidowicz, Karolina, Jiao Jin, Sejal R. Ranmal, et al. "Characterisation and sensory evaluation of placebo OrPhyllo ^TM orodispersible films as a versatile paediatric drug delivery platform." Drug Development and Industrial Pharmacy, June 19, 2025, 1–15. https://doi.org/10.1080/03639045.2025.2521664.

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Muramoto, Shin. "Towards Pharmaceutical Particle Imaging in Ultrathick Organic Films: 3D Visualization and Image Distortions Using Gas Cluster Bombardment Secondary Ion Mass Spectrometry." Surface and Interface Analysis, December 10, 2024. https://doi.org/10.1002/sia.7373.

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ABSTRACTPolystyrene spheres ranging in diameter from 2, 5, 10, to 20 μm were embedded in five different types of thick organic films (> 50 μm) to serve as model systems to evaluate the use of time‐of‐flight secondary ion mass spectrometry for the localization and particle sizing of pharmaceuticals in orodispersible drug delivery films. It was found that certain films, such as gelatin and ethyl cellulose, are prone to developing micron‐scale topography which can affect the linearity of the sputter yield, which can ultimately affect the maximum analyzable depth. Surprisingly, the sputter yiel

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Breithaupt, Mareile H., Evelyn Krohmer, Lenka Taylor, et al. "Oral bioavailability of microdoses and therapeutic doses of midazolam as a 2-dimensionally printed orodispersible film in healthy volunteers." European Journal of Clinical Pharmacology, October 18, 2022. http://dx.doi.org/10.1007/s00228-022-03406-y.

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Abstract Purpose The use of two-dimensional (2D) printing technologies of drugs on orodispersible films (ODF) can promote dose individualization and facilitate drug delivery in vulnerable patients, including children. We investigated midazolam pharmacokinetics after the administration of 2D-printed ODF. Methods Midazolam doses of 0.03 and 3 mg were printed on an ODF using a 2D drug printer. We investigated the bioavailability of the two midazolam doses with ODF swallowed immediately (ODF-IS) or delayed after 2 min (ODF-DS) by comparing their pharmacokinetics with intravenous and oral midazolam

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