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Relevant bibliographies by topics / Drug delivery systems. Polymeric drugs. Drugs / Dissertations / Theses

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Dissertations / Theses on the topic 'Drug delivery systems. Polymeric drugs. Drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Zhang, Feng. "Hot-melt extrusion as a novel technology to prepare sustained-release dosage forms /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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2

Lindell, Katarina. "An investigation of thermogelling aqueous systems of ethyl (hydroxyethyl) cellulose and ionic surfactants." Lund : Lund University, Dept. of Food Technology, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38100698.html.

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3

Mawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.

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Introduction: Embolic agents are used to block blood flow of hypervascular tumours, ultimately resulting in target tissue necrosis. However, this therapy is limited by the formation of new blood vessels within the tumour, a process known as angiogenesis. Targeting angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an embolic agent for delivery of macromolecular drugs

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4

Mahaguna, Vorapann. "Investigation of cellulose ether polymers in controlled drug delivery." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037524.

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5

Basu, Sarkar Arindam Kochak Gregory Michael. "Carbohydrate nanoparticles a novel drug delivery platform for the systemic route /." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Dissertations/BASU_SARKAR_26.pdf.

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6

Soane, Robert J. "Bioadhesive polymers as intranasal drug delivery systems for peptide and protein drugs." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298078.

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7

Teng, Yue. "Solubilization and release studies of small molecules in polymeric micelles /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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8

Ramirez, Carmen Hernandez. "Enhancement of the rate of solution of relatively insoluble drugs from solid-solid systems prepared by supercritical fluid technology." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1179928429.

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9

Özgarip, Yarkın Bayraktar Oğuz. "Application of Silk Fibroin In Controlled-Release of Theophylline/." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/kimyamuh/T000433.pdf.

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10

Kao, Chen-Yu. "Local and sustained delivery of hydrophobic drugs to the spinal cord with polyketal microparticles." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37304.

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Amyotrophic lateral sclerosis (ALS) is a devastating disease. Currently, there is no cure for this disease, and effective treatment strategies are greatly needed. Calpain activation plays a major role in the motor neuron degeneration that causes ALS. Therefore, therapeutic strategies can inhibit calpain activity in the central nervous system (CNS) have great clinical potential. The calpain inhibitors AK295 and MDL-28170 have been demonstrated to be neuroprotective in animal models of neurological injury, and should have great potential to treat ALS; however delivery problems have hindered t

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11

Shkodra, Blerina [Verfasser], Ulrich Sigmar [Gutachter] Schubert, and Oliver [Gutachter] Werz. "Design and development of polymeric nanoparticles as delivery systems for anti-inflammatory drugs / Blerina Shkodra ; Gutachter: Ulrich Sigmar Schubert, Oliver Werz." Jena : Friedrich-Schiller-Universität Jena, 2021. http://d-nb.info/123814201X/34.

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12

Eduardo, Da Silva Acarilia. "Nanotechnological delivery systems for the oral administration of active molecules : Polymeric microparticles and microemulsions applied to anti-inflammatory and anti-infectious drugs." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00856598.

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This thesis was devoted to the development of innovative oral delivery systems for two different molecules. In the first part, microparticles (MPs) based on xylan and Eudragit® S-100 were produced and used to encapsulate 5-aminosalicylic acid for colon delivery. Xylan was extracted from corn cobs and characterized in terms of its physicochemical, rheological and toxicological properties. The polymeric MPs were prepared by interfacial cross-linking polymerization and spray-drying and characterized for their morphology, mean size and distribution, thermal stability, crystallinity, entrapment eff

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13

Silva, Acarilia Eduardo da. "Nanotechnological delivery systems for the oral administration of active molecules: Polymeric microparticles and microemulsions applied to anti-inflammatory and anti-infectious drugs." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13309.

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Made available in DSpace on 2014-12-17T14:13:48Z (GMT). No. of bitstreams: 1 AcariliaES_TESE.pdf: 9221805 bytes, checksum: 71876e327362584aeb9dcac7d3652c4d (MD5) Previous issue date: 2013-04-05<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>This thesis was devoted to the development of innovative oral delivery systems for two different molecules. In the first part, microparticles (MPs) based on xylan and Eudragit? S- 100 were produced and used to encapsulate 5-aminosalicylic acid for colon delivery. Xylan was extracted from corn cobs and characterized in terms of its phy

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14

Ketkar, Amol Sharad. "Polymeric drug delivery systems /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487859879937796.

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15

Chakrapani, Aravind. "Processing and characterization of polymer microparticles for controlled drug delivery systems." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164827297.

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16

Ogden, Dorothy. "Modifiable Hyperbranched Polyester Drug Delivery Systems." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520.

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17

Park, Jung-Hwan. "Polymeric microneedles for transdermal drug delivery." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131324/unrestricted/park%5Fjung-hwan%5F200405%5Fphd.pdf.

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18

Bailly, Nathalie. "N-vinylpyrrolidone-vinyl acetate block copolymers as drug delivery vehicles." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20133.

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Thesis (PhD)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The primary aim of this study was to investigate the feasibility of the amphiphilic block copolymer poly((vinylpyrrolidone)-b-poly(vinyl acetate)) (PVP-b-PVAc) as a vehicle for hydrophobic anti-cancer drugs. PVP-b-PVAc block copolymers of constant hydrophilic PVP block length and varying hydrophobic PVAc block lengths were synthesized via xanthate-mediated controlled radical polymerization (CRP). The methodology consisted of growing the PVAc chain from a xanthate end-functional PVP. In an aqueous environment the amphiphili

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19

Zaid, Alkilani Ahlam. "Polymeric microneedle systems for transdermal drug delivery." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603301.

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Delivery across skin offers many advantages compared to oral or parenteral routes e.g. non-invasive, avoiding first-past metabolism, improved bioavailability and reduction of systemic side effects. Microneedle (MN) are minimally-invasive devices that painlessly by-pass the skin's stratum corneum, which is the principal barrier to topically-applied drugs. Polymeric MN delivery systems were designed and evaluated to transdermally deliver two model drugs, the small water soluble drug ibuprofen sodium and the large protein ovalbumin (OVA). A range of hydrogel forming materials for MN production wa

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20

Yang, Stephen Chen. "Polyketals a new drug delivery platform for treating acute liver failure /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31785.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Murthy, Niren; Committee Member: Bellamkonda, Ravi; Committee Member: Davis, Michael; Committee Member: May, Sheldon; Committee Member: Milam, Valeria. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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21

Chang, Kai. "Structural modification of poly(n-isopropylacrylamide) for drug delivery applications." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/48947.

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Polymeric biomaterials have become ubiquitous in modern medical devices. ‘Smart’ materials, materials that respond to external stimuli, have been of particular interest for biomedical applications such as drug delivery. Poly(n-isopropylacrylamide) (pNIPAAm) is the best studied thermally responsive, biocompatible, ‘smart’ polymer and has been integrated into many potential drug delivery devices; however, the architectural design of the polymer in these devices is often overlooked. My research focus was the exploration of pNIPAAm architecture for biological applications. Two new biomaterials w

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22

Zhu, Chongyu. "Polymeric drug delivery systems for biological antimicrobial agents." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/91996/.

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The objective of this work was to develop suitable delivery systems for biological agents that have antimicrobial activities using biocompatible polymers, aiming to reduce their toxicity when administered. Two biological agents, colistin as an antibacterial agent and nystatin (Nys) as an antifungal agent, are the focus of this thesis as they are potent treatments for current pathogen infections, especially to the multidrug-resistant (MDR) bacteria/fungi, but have potential toxicity to human. Polymeric drug delivery systems, including prodrug, hydrogel and micelle formulations, have been develo

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23

Sutton, Damon Michael. "PH SENSITIVE RNA AND DRUG DELIVERY SYSTEMS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1179847644.

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24

Glässl, Bianca. "On the importance of drug-polymer interactions in controlled drug delivery systems." Lille 2, 2009. http://www.theses.fr/2009LIL2S026.

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L’objectif de cette thèse était de mieux comprendre le mécanisme d’interaction entre le tartrate de métoprolol et des films de polymethacrylate quaternaire (Eudragit RL et Eudragit RS). Pour des raisons de comparaison, des films contenant soit la base libre du métoprolol soit l’acide tartrique libre ont été préparés. Tout d’abord, les systèmes contenant une quantité variable d’un de ces composés (l’acide libre, la base libre ou le sel) ont été caractérisés à l’état sec par microscopie à lumière polarisée, diffraction des rayons X, analyse enthalpique différentielle et analyse des propriétés mé

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25

Donnelly, L. "Synthesis and characterisation of novel polymeric drug delivery systems." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398150.

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26

Benzine, Youcef. "Enzymatically triggered polymeric drug delivery systems for colon targeting." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S036.

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De nos jours, les maladies inflammatoires chroniques de l'intestin (MICI) comme la rectocolite hémorragique et la maladie de Crohn touchent près de 200 000 personnes en France. Elles se caractérisent par l'inflammation de la paroi de différentes régions du tractus gastro-intestinal (TGI). Les deux sont des maladies chroniques qui impliquent une inflammation de la muqueuse colique. La principale différence entre la maladie de Crohn et la rectocolite hémorragique réside dans la localisation et la nature de l’inflammation. La maladie de Crohn peut toucher n’importe quelle partie du tractus gastro

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27

Kola-Mustapha, Adeola Tawakalitu. "Novel biomimetic polymeric nanoconjugates as drug delivery carriers for poorly soluble drugs." Thesis, De Montfort University, 2013. http://hdl.handle.net/2086/10243.

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Active Pharmaceutical Ingredients with poor solubility have presented significant difficulties in drug product design and development including slow and ineffective absorption leading to inadequate and variable bioavailability. Therefore it has become increasingly desirable to overcome the low aqueous solubility of drug candidates and develop more novel and innovative formulation approaches to increase the dissolution rate of the poorly soluble drugs. This work focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to impr

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28

Grandelli, Heather Eilenfield. "Formation of Cyclodextrin-Drug Inclusion Compounds and Polymeric Drug Delivery Systems using Supercritical Carbon Dioxide." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23891.

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New methods for the preparation of porous biomedical scaffolds have been explored for applications in tissue engineering and drug delivery. Scaffolds with controlled pore morphologies have been generated which incorporate cyclodextrin-drug inclusion complexes as the drug delivery component. Supercritical CO2 was explored as the main processing fluid in the complex formation and in the foaming of the polymer scaffold. The co-solvents, ethanol, ethyl acetate and acetone, were explored in each stage, as needed, to improve the solvent power of CO2. The first goal was to promote cyclodextri

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29

Nguyen, Duong Thuy. "Self-assembly Polymeric Nanoparticles Composed of Polymers Crosslinked with Transition Metals for Use in Drug Delivery." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822738/.

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A major drawback of chemotherapy is the lack of selectively leading to damage in healthy tissue, which results in severe acute side effects to cancer patients. The use of nanoparticles as a drug delivery system has emerged as novel strategy to overcome the barriers of immunogenic response, controlled release of therapeutic, and targeting the toxicity only to cancerous cells. In this study, polymeric nanoparticles composed of transition metals and particles derived from natural biopolymers have been generated via self-assembly. For example, nanoparticles composed of cobalt crosslinked with a

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30

Li, Ying Jean Y. C. "Free volume properties of drug delivery polymers studied by positron annihilation spectroscopy." Diss., UMK access, 2004.

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Thesis (Ph. D.)--Dept. of Chemistry and School of Computing and Engineering. University of Missouri--Kansas City, 2004.<br>"A dissertation in chemistry and software architecture." Advisor: Yan-Ching Jean. Typescript. Vita. Description based on contents viewed Feb. 27, 2006; title from "catalog record" of the print edition. Includes bibliographical references (leaves 205-218). Online version of the print edition.

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31

Rosenbaum, Erik. "Optical characterization of potential drugs and drug delivery systems." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40177.

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This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. These methods include optical absorption and fluorescence as well as time-resolved fluorescence. Upon covalently linking compounds with high quantum yields of fluorescence to specific parts of the pilicide, the biological impact was found to increase for some of the derivatives. Furthermore, by expanding the aromatic part of

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32

Mackenzie, R. C. "Computational modelling of polymer-based drug delivery systems." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28852/.

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Polymer-based drug delivery systems have fantastic potential in chemotherapy as they can reduce drug side effects, help in patient compliance and provide targeting. Nanoprecipitation is used to encapsulate small drug molecules into polymer nanoparticles to form a drug delivery system. A major obstacle in polymer-based drug delivery systems reaching the clinic is their inability to load sufficient drug molecules. Little is known about the processes involved in the encapsulation of drug molecules into these delivery systems. An insight into the processes that govern the formation of these partic

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33

Bragger, Janine Lesley. "The design of drug delivery systems for the colon." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307587.

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34

Deadman, Claire Michelle. "Biopharmaceutical studies of slow release, subcutaneous polymeric drug delivery systems." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433154.

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35

Mishra, Kaushik. "Folate Receptor-Targeted Polymeric Micellar Nanocarriers as Drug Delivery Systems." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1629218263972419.

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36

Baki, Mert. "Bone Marrow Targeted Liposomal Drug Delivery Systems." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613251/index.pdf.

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Homing is the process that stem cells move to their own stem cell niches under the influence of chemokines like stromal-derived factor-1&alpha<br>(SDF-1&alpha<br>) upon bone marrow transplantation (BMT). There is a need for increasing homing efficiency after BMT since only 10-15% of the transplanted cells can home to their own niches and a limited amount of donor marrow can be transplanted. In this study, we aimed to develop and characterize bone marrow targeted liposomal SDF-1&alpha<br>delivery system prepared by extrusion method. Alendronate conjugation was chosen to target the liposomes to

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37

Swami, Salesh N., University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." THESIS_CSTE_SFH_Swami_S.xml, 2004. http://handle.uws.edu.au:8081/1959.7/698.

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Hydrogels are three dimensional networks of hydrophilic homopolymers or copolymers generally covalently or ionically crosslinked. They interact with aqueous media by swelling to some equilibrium value by retaining the aqueous media in their structures. This study concerns the investigation of the swelling and the controlled drug release behaviour of hydrogels synthesized via the photopolymerisation process. The study of hydrogels in this project was oriented towards their biomedical applications as controlled drug delivery devices. It is a known fact that the complete conversion of monomers to

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38

Cadotte, Alex Joseph. "Polymeric drug delivery of antiepileptic drugs to neuronal networks cultured on multielectrode arrays." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006042.

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39

Schultze, Jennifer [Verfasser]. "Polymer-Based Systems for Drug Delivery Studies / Jennifer Schultze." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1186179627/34.

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40

Elahrash, K. S. "Some physical studies with polymer based drug delivery systems." Thesis, University of Brighton, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354875.

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41

Eisenbrey, John Wheatley Margaret A. "Ultrasound sensitive polymeric drug carriers for treatment of solid tumors /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3218.

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42

Murthy, Niren. "The design and synthesis of endosomal disruptive polymers /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/8113.

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43

Romão, Joana Isabel Sobral. "Development of cyclodextrin-hydrogel polymeric systems in scCO2 for drug delivery." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6134.

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Thesis for the Degree of Master of Science in Bioorganic Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia<br>This work describes the studies on the development of new cyclodextrin-hydrogel systems in supercritical carbon dioxide (scCO2) with potential application in drug delivery. Three β-cyclodextrin (CDs) derivatives were synthesized: 6-monoacryloyl-β-CD, 2-monoacryloyl-β-CD and 6-monoacryloly-heptakis-(2,3-di-O-benzyl)-β-CD. Their structures were assigned by nuclear magnetic resonance (NMR), infrared (IR) and mass spectrometry (MS) using the technique of matrix-assisted lase

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44

Dollendorf, Christian [Verfasser], and Helmut [Akademischer Betreuer] Ritter. "Polymere Drug-Delivery Systeme / Christian Dollendorf. Betreuer: Helmut Ritter." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1036727505/34.

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Dollendorf, Christian Verfasser], and Helmut [Akademischer Betreuer] [Ritter. "Polymere Drug-Delivery Systeme / Christian Dollendorf. Betreuer: Helmut Ritter." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://nbn-resolving.de/urn:nbn:de:hbz:061-20130703-134552-6.

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46

Komurcu, Ramazan. "Tryptamine terminated 1st generation polyamide dendrimer synthesis and drug release /." Akron, OH : University of Akron, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1196653318.

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Thesis (M.S.)--University of Akron, Dept. of Chemical Engineering, 2007.<br>"December, 2007." Title from electronic thesis title page (viewed 02/25/2008) Advisor, Stephanie T. Lopina; Faculty readers, Bi-min Newby, Helen Qammar; Department Chair, Lu-Kwang Ju; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.

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47

Liu, Weipeng. "Biopolymer-based ocular drug delivery systems." Diss., Connect to online resource - MSU authorized users, 2008.

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48

Zeng, Yi. "Stable Polymer Micelle Systems as Anti-cancer Drug Delivery Carriers." Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd841.pdf.

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49

Heffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.

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Thesis (Ph.D.)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.

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50

Javaheri, Hoda. "Wet granulated liquisolid drug delivery systems with hydrophobic and hydrophilic drugs." Thesis, University of Sunderland, 2017. http://sure.sunderland.ac.uk/8549/.

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The formulation of hydrophobic drugs into appropriate dosage forms is challenging due to the problems associated with those drugs such as low solubility and poor dissolution. Using a liquisolid system is a promising method to improve the dissolution of hydrophobic drugs and in sustaining the release of hydrophilic drugs, in which solid drugs are dispersed in non-volatile liquid vehicles. The aim of this research was to use the liquisolid technique to enhance the dissolution rate of glibenclamide, a model hydrophobic drug, and to sustain the release of metformin-HCl, as a model hydrophilic drug

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