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Journal articles on the topic 'Drug delivery systems. Polymeric drugs. Drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Kennedy, John F., and Giampiero Pagliuca. "Polymeric Drugs and Drug Delivery Systems." Carbohydrate Polymers 18, no. 4 (1992): 311–12. http://dx.doi.org/10.1016/0144-8617(92)90098-b.

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2

Davies, M. "Polymeric Drugs and Drug Delivery Systems." Biomaterials 14, no. 3 (1993): 239. http://dx.doi.org/10.1016/0142-9612(93)90033-x.

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3

Langer, Robert. "Drug Delivery Systems." MRS Bulletin 16, no. 9 (1991): 47–49. http://dx.doi.org/10.1557/s0883769400056050.

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For many years, drug delivery systems were composed of simple pills, eyedrops, ointments, or intravenous solutions. Recently, materials have begun to play a major role in improving drug delivery. Drugs are now chemically attached to polymers, entrapped in small vesicles that are injected into the bloodstream, or put in pumps or polymeric materials that are placed in the body. These new materials-based systems are beginning to change the way drugs can be administered and, in so doing, have improved human health. This article provides a brief review of the major classes of drug delivery systems;

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Thatte, Suhas, Kapil Datar, and Raphael M. Ottenbrite. "Perspectives On: Polymeric Drugs and Drug Delivery Systems." Journal of Bioactive and Compatible Polymers 20, no. 6 (2005): 585–601. http://dx.doi.org/10.1177/0883911505059549.

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Sizochenko, Natalia, and Jerzy Leszczynski. "Drug-Nanoparticle Composites." Journal of Nanotoxicology and Nanomedicine 2, no. 1 (2017): 1–10. http://dx.doi.org/10.4018/jnn.2017010101.

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Polymeric nanoparticles represent attractive targets for the controlled delivery of therapeutic drugs. Drug-nanoparticle conjugates are convenient targets to enhance solubility and membrane permeability of drugs, prolong circulation time and minimize non-specific uptake. The behavior of drugs-loaded nanoparticles is governed by various factors. Understanding of these effects is very important for design of drug-nanoparticle systems, that could be suitable for treating the particular diseases. The aim of the current study is a complementary molecular docking followed by quantitative structure-a

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Ahmad, Zaheer, Afzal Shah, Muhammad Siddiq, and Heinz-Bernhard Kraatz. "Polymeric micelles as drug delivery vehicles." RSC Adv. 4, no. 33 (2014): 17028–38. http://dx.doi.org/10.1039/c3ra47370h.

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Villarreal-Gómez, Luis Jesús, Aracely Serrano-Medina, Erick José Torres-Martínez, Graciela Lizeth Perez-González, and José Manuel Cornejo-Bravo. "Polymeric advanced delivery systems for antineoplasic drugs: doxorubicin and 5-fluorouracil." e-Polymers 18, no. 4 (2018): 359–72. http://dx.doi.org/10.1515/epoly-2017-0202.

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AbstractConventional pharmaceuticals generally display the inability to transport active ingredients directly to specific regions of the body, amongst some of their main limitations. The distribution of the drugs in the circulatory system may lead to undesired toxicity, and therefore, adverse reactions. To address this situation, a selective transport of drugs is required, that is, releasing drugs specifically to the site of action in appropriate concentrations and in the right time. To achieve this goal, it is necessary to develop delivery systems that respond to several features, such as low

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Torres-Martinez, Erick José, Graciela Lizeth Pérez-González, Aracely Serrano-Medina, et al. "Drugs Loaded into Electrospun Polymeric Nanofibers for Delivery." Journal of Pharmacy & Pharmaceutical Sciences 22 (July 16, 2019): 313–31. http://dx.doi.org/10.18433/jpps29674.

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The electrospinning technique is a useful and versatile approach for conversion of polymeric solutions into continuous fibers, ranging from a few micrometers (10–100 μm) to the scale of nanometers (10–100 nm) in diameters. This technique can be used in a vast number of polymers, in some cases after modifying them to the required properties. The high surface-to-volume ratio of the fibers can improve some processes like cell binding and proliferation, drug loading, and mass transfer processes. One of the most important and studied areas of electrospinning is in the drug delivery field, for the c

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Jain, Shikha, Vikas Jain, and S. C. Mahajan. "Lipid Based Vesicular Drug Delivery Systems." Advances in Pharmaceutics 2014 (September 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/574673.

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Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in th

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Ahlawat, Jyoti, Gabriela Henriquez, and Mahesh Narayan. "Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles." Molecules 23, no. 9 (2018): 2157. http://dx.doi.org/10.3390/molecules23092157.

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While pharmaceutical drugs have revolutionized human life, there are several features that limit their full potential. This review draws attention to some of the obstacles currently facing the use of chemotherapeutic drugs including low solubility, poor bioavailability and high drug dose. Overcoming these issues will further enhance the applicability and potential of current drugs. An emerging technology that is geared towards improving overall therapeutic efficiency resides in drug delivery systems including the use of polymeric nanoparticles which have found widespread use in cancer therapeu

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AbdElhamid, Ahmed S., Dina G. Zayed, Lamia Heikal, et al. "Recent advances in polymer shell oily-core nanocapsules for drug-delivery applications." Nanomedicine 16, no. 18 (2021): 1613–25. http://dx.doi.org/10.2217/nnm-2021-0037.

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Polymeric nanocapsules are vesicular drug-delivery systems composed of an inner oily reservoir surrounded by polymeric membranes. Nanocapsules have various advantages over other nanovesicular systems such as providing controlled drug release properties. We discuss the recent advances in polymeric shell oily-core nanocapsules, illustrating the different types of polymers used and their implementation. Nanocapsules can be utilized for many purposes, especially encapsulation of highly lipophilic drugs. They have been shown to have variable applications, especially in cancer therapy, due to the ab

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Prajakta N. Dongare, Anuja S. Motule, Mahesh R. Dubey, et al. "Recent development in novel drug delivery systems for delivery of herbal drugs: An updates." GSC Advanced Research and Reviews 8, no. 2 (2021): 008–18. http://dx.doi.org/10.30574/gscarr.2021.8.2.0158.

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In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs.

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Dumitriu, Severian, Marcel Popa, and Maria Dumitriu. "Review : Polymeric Biomaterials As Enzyme and Drug Carriers* Part III: Polymeric Drugs and Drug Delivery Systems." Journal of Bioactive and Compatible Polymers 4, no. 1 (1989): 57–73. http://dx.doi.org/10.1177/088391158900400107.

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Choubdar, Niloufar, and Sara Avizheh. "Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease." Nanoscience & Nanotechnology-Asia 10, no. 3 (2020): 228–47. http://dx.doi.org/10.2174/2210681209666190228143636.

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Alzheimer’s Disease (AD) is one of the most common forms of dementia affecting over 46 million people, according to AD International. Over the past few decades, there has been considerable interest in developing nanomedicines. Using nanocarriers, the therapeutic compound could be delivered to the site of action where it gets accumulated. This accumulation, therefore, reduces the required doses for therapy. Alternatively, using nanocarriers decreases the side effects. Nanotechnology has had a great contribution in developing Drug Delivery Systems (DDS). These DDS could function as reservoirs fo

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Chiellini, Elisabetta E., Federica Chiellini, and Roberto Solaro. "Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3040–47. http://dx.doi.org/10.1166/jnn.2006.412.

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Significant efforts are being devoted to develop nanotechnology for drug delivery, mainly because of the distinct advantages offered by nanometer-size polymeric systems. Moreover, targeted drug delivery can be obtained by polymer conjugation to biospecific ligands. The present investigation was aimed mainly at determining the targeting ability of hybrid nanoparticles based on synthetic polymer/protein hybrid matrices. These nanoparticles were designed for liver targeted release of proteic drugs with antiviral activity, such as α-interferon. Human serum albumin and the monoesters of alternating

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Ray, Priyanka. "Polymer based Drug Delivery Systems- benchtop to Bedside Transition." Journal of Drugs Addiction & Therapeutics 2, no. 2 (2021): 1–3. http://dx.doi.org/10.47363/jdat/2021(2)113.

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Research in the field of polymers and polymeric materials has garnered immense attention in the past few decades due to the versatile functional and structural capabilities of polymers which often can be manipulated for applications in the field of therapy and diagnosis for a host of diseases and disorders. Polymer therapeutics comprises polymer-drug and polymer-protein conjugates as well as supramolecular systems used as drug delivery systems. Although the pharmacological industry invests immensely in the design and discovery of novel drug molecules, small molecular drugs are often inefficien

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Pan, Jiayi, Kobra Rostamizadeh, Nina Filipczak, and Vladimir Torchilin. "Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect." Molecules 24, no. 6 (2019): 1035. http://dx.doi.org/10.3390/molecules24061035.

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Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartment

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Majumder, Nairrita, Nandita G Das, and Sudip K. Das. "Polymeric micelles for anticancer drug delivery." Therapeutic Delivery 11, no. 10 (2020): 613–35. http://dx.doi.org/10.4155/tde-2020-0008.

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Polymeric micelles have gained interest as novel drug delivery systems for the treatment and diagnosis of cancer, as they offer several advantages over conventional drug therapies. This includes drug targeting to tumor tissue, in vivo biocompatibility and biodegradability, prolonged circulation time, enhanced accumulation, retention of the drug loaded micelle in the tumor and decreased side effects. This article provides an overview on the current state of micellar formulations as nanocarriers for anticancer drugs and their effectiveness in cancer therapeutics, including their clinical status.

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Francis, M. F., Mariana Cristea, and F. M. Winnik. "Polymeric micelles for oral drug delivery: Why and how." Pure and Applied Chemistry 76, no. 7-8 (2004): 1321–35. http://dx.doi.org/10.1351/pac200476071321.

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The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects owing to increased patient compliance. Unfortunately, the oral delivery route is beset with problems such as gastrointestinal (GI) destruction of labile molecules, low levels of macromolecular absorption, etc. To reduce the impact of digestive enzymes and to ensure the absorption of bioactive agents in an unaltered form, molecules may be incorporated into microparticulate carriers. Many approaches to achieve the oral absorption of a wide variety of drugs are currently under investigation. Among the di

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Nair, Praful R. "Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems." Polymers 11, no. 4 (2019): 630. http://dx.doi.org/10.3390/polym11040630.

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The side-effects associated with chemotherapy necessitates better delivery of chemotherapeutics to the tumor. Nanoparticles can load higher amounts of drug and improve delivery to tumors, increasing the efficacy of treatment. Polymeric nanoparticles, in particular, have been used extensively for chemotherapeutic delivery. This review describes the efforts made to deliver combination chemotherapies and inhibit oncogenic pathways using polymeric drug delivery systems. Combinations of chemotherapeutics with other drugs or small interfering RNA (siRNA) combinations have been summarized. Special at

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Alves, Vinicius M., Duhyeong Hwang, Eugene Muratov, et al. "Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs." Science Advances 5, no. 6 (2019): eaav9784. http://dx.doi.org/10.1126/sciadv.aav9784.

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Many drug candidates fail therapeutic development because of poor aqueous solubility. We have conceived a computer-aided strategy to enable polymeric micelle-based delivery of poorly soluble drugs. We built models predicting both drug loading efficiency (LE) and loading capacity (LC) using novel descriptors of drug-polymer complexes. These models were employed for virtual screening of drug libraries, and eight drugs predicted to have either high LE and high LC or low LE and low LC were selected. Three putative positives, as well as three putative negative hits, were confirmed experimentally (i

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Heggannavar, Geetha B., Divya Achari, Cristiana Fernandes, Geoffrey R. Mitchell, Pedro Morouço, and Mahadevappa Y. Kariduraganavar. "Smart Polymers in Drug Delivery Applications." Applied Mechanics and Materials 890 (April 2019): 324–39. http://dx.doi.org/10.4028/www.scientific.net/amm.890.324.

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The most important components of living cells such as carbohydrates, proteins and nucleic acids are the polymeric molecules. Nature utilizes polymers both as constructive elements and as a part of the complicated cell machinery of living things. The rapid advancement in biomedical research has led to many creative applications for biocompatible polymers. With the development of newer and more potent drugs, a parallel expansion in more sophisticated drug delivery systems becomes mandatory. Smart polymeric drug-delivery systems have the ability to respond to environmental changes and consequentl

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Misiak, Paweł, Karolina H. Markiewicz, Dawid Szymczuk, and Agnieszka Z. Wilczewska. "Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review." Polymers 12, no. 11 (2020): 2620. http://dx.doi.org/10.3390/polym12112620.

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This review aims to provide an overview of polymers comprising cholesterol moiety/ies designed to be used in drug delivery. Over the last two decades, there have been many papers published in this field, which are summarized in this review. The primary focus of this article is on the methods of synthesis of polymers bearing cholesterol in the main chain or as side chains. The data related to the composition, molecular weight, and molecular weight distribution of polymers are presented. Moreover, other aspects, such as forms of carriers, types of encapsulated drugs, encapsulation efficiency and

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Ameen, Muath Sheet Mohammed, Rishabha Malviya, Omji Porwal, Esra Tariq Anwar, Sumedha Pant, and Akanksha Sharma. "Novel Strategies and Model Studies for Colon Targeted Drug Delivery." Drug Delivery Letters 11, no. 2 (2021): 156–63. http://dx.doi.org/10.2174/2210303111666210118141406.

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Targeting drugs with controlled release characteristics to the colon is gaining importance for localized action as well as to improve the systemic availability of peptides and proteins. The present manuscript aims to describe the various approaches and model study for colon targeted drug delivery. Drugs that have low absorption window are targeted into in the colonic regions using different novel technologies such as microparticulate system, prodrugs, pH and time dependent polymeric, effervescent and noneffervescent systems etc. Along with this it manuscript also describes the model study for

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Lynch, Courtney, Pierre P. D. Kondiah, Yahya E. Choonara, Lisa C. du Toit, Naseer Ally, and Viness Pillay. "Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery." Polymers 11, no. 8 (2019): 1371. http://dx.doi.org/10.3390/polym11081371.

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The effective delivery of drugs to the eye remains a challenge. The eye has a myriad of defense systems and physiological barriers that leaves ocular drug delivery systems with low bioavailability profiles. This is mainly due to poor permeability through the epithelia and rapid clearance from the eye following administration. However, recent advances in both polymeric drug delivery and biomedical nanotechnology have allowed for improvements to be made in the treatment of ocular conditions. The employment of biodegradable polymers in ocular formulations has led to improved retention time, great

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Franco, Paola, and Iolanda De Marco. "Contact Lenses as Ophthalmic Drug Delivery Systems: A Review." Polymers 13, no. 7 (2021): 1102. http://dx.doi.org/10.3390/polym13071102.

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Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of op

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Wang, Jing, Xueqing Xing, Xiaocui Fang, et al. "Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 371, no. 2000 (2013): 20120309. http://dx.doi.org/10.1098/rsta.2012.0309.

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Since polymeric micelles are promising and have potential in drug delivery systems, people have become more interested in studying the compatibility of polymeric carriers and drugs, which might help them to simplify the preparation method and increase the micellar stability. In this article, we report that cationic amphiphilic drugs can be easily encapsulated into PEGylated phospholipid (PEG–PE) micelles by self-assembly method and that they show high encapsulation efficiency, controllable drug release and better micellar stability than empty micelles. The representative drugs are doxorubicin

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Rao, Monica RP, Ashwini Sonawane, Sharwari Sapate, and Kshitija Abhang. "Exploring Recent Advances in Nanotherapeutics." Journal of Drug Delivery and Therapeutics 10, no. 5-s (2020): 273–80. http://dx.doi.org/10.22270/jddt.v10i5-s.4484.

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Nanotechnology is a rapidly expanding field, encompassing the development of materials in a size range of 5-200 nanometers (nm). The applications of nanotechnology to drug delivery opened the floodgates to create novel therapeutics and diagnostics which have changed the landscape of pharmaceutical and biotechnological industries. Advances in nanotechnology are being utilized in medicine for therapeutic drug delivery and treatment of various diseases and disorders. The biodegradable nanoparticle/nanocarriers, in which drug is dissolved and entrapped are specially designed to absorb the drug and

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Dhal, Pradeep K., Chad C. Huval, and S. Randall Holmes-Farley. "Biologically active polymeric sequestrants: Design, synthesis, and therapeutic applications." Pure and Applied Chemistry 79, no. 9 (2007): 1521–30. http://dx.doi.org/10.1351/pac200779091521.

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In recent years, functional polymers exhibiting inherently biological activities have been receiving increasing attention as polymer-based human therapeutic agents. These polymeric drugs exhibit unique pharmaceutical properties that are fundamentally different from their traditional small-molecule counterparts. However, unlike polymeric drug delivery systems, examples of polymers possessing intrinsically therapeutic properties are relatively scarce. By virtue of their high-molecular-weight characteristics, these polymeric drugs can be confined to the gastrointestinal (GI) tract, where they can

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Pooja Mallya, Gowda D V, Mahendran B, Bhavya M V, and Vikas Jain. "Recent developments in nano micelles as drug delivery system." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 176–84. http://dx.doi.org/10.26452/ijrps.v11i1.1804.

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Targeting of the drug directly to the cells, tissues, or organs with no impact on healthy cells is a challenge. In the current era, it's been made possible by therapeutic interventions. The novel drug delivery systems such as nano particulates, liposomes, aquasomes, phytosomes, dendrimers, nano sponges, nano micelles are developed. Nano micelles are developed for efficient targeting and are currently in trend as therapeutic carriers of water-insoluble drugs. Micelles are self-assembling Nano-sized colloidal particles with a hydrophobic core and hydrophilic shell. Among the micelle-forming comp

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Biswas, Swati. "Polymeric micelles as drug-delivery systems in cancer: challenges and opportunities." Nanomedicine 16, no. 18 (2021): 1541–44. http://dx.doi.org/10.2217/nnm-2021-0081.

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Tweetable abstract Micelles are nanocarriers for hydrophobic chemotherapeutic drugs. This editorial discusses the current status of preclinical micellar research and sheds light on the possibility of their clinical translation.

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Zorkina, Yana, Olga Abramova, Valeriya Ushakova, et al. "Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations." Molecules 25, no. 22 (2020): 5294. http://dx.doi.org/10.3390/molecules25225294.

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Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. One of the problem-solving methods is the usage of nanocontainer systems. In this review we summarized the data about nanoparticles drug delivery systems and their application for the treatment of neuropsychiatric disorders. Firstly, we described and characterized types of nanocarriers: inorganic

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Neha, Bhatt, Bhatt Ganesh, and Kothiyal Preeti. "Drug Delivery to The Brain Using Polymeric Nanoparticles: A Review." International Journal of Pharmaceutical and Life Sciences 2, no. 3 (2013): 107–32. http://dx.doi.org/10.3329/ijpls.v2i3.15457.

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Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50300 nm generally). The use of minute particles as drug carriers for targeted treatment has been studied over a long period of time. A selective accumulation of active substances in target tissues has been demonstrated for certain so-called nanocarrier systems that are administered bound to pharmaceutical drugs. Great expectations are placed on nanocarrier systems that can overcome natural barriers such as the blood-brain barrier (BBB) and transport the medication directly to the desired t

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Mouriño, Viviana, and Aldo R. Boccaccini. "Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds." Journal of The Royal Society Interface 7, no. 43 (2009): 209–27. http://dx.doi.org/10.1098/rsif.2009.0379.

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This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs. Typical drugs considered include gentamicin and other antibiotics generally used to combat osteomyelitis, as well as anti-inflammatory drugs and bisphosphonates, but delivery of growth factors is not covered in this review. In each case reviewed, special attention has been given to the technology used for controlling the release of the loaded drugs. The possibili

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Yahya, Ibtihag, Razan Atif, Lina Ahmed, Tahleel Salah Eldeen, Akram Omara, and Megdi Eltayeb. "Polymeric Nanoparticles as Drug Delivery Systems for Controlled Release." Advanced Science, Engineering and Medicine 12, no. 2 (2020): 263–70. http://dx.doi.org/10.1166/asem.2020.2495.

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This study focuses on providing a comparative mathematical analysis of drug release from polymeric nanoparticle with different structures to allow in silico prediction of the appropriate and optimal model that applies to the whole drug release and not limited to a part of the process. The drug release data from nanoparticles have been applied using MATLAB software to apply mathematical models such as Zero-order, First-order, Higuchi, Hixson–Crowell, Korsmeyer-Peppas models besides a proposed model called Tanh function. This study results highlight the usefulness of mathematical models, key fin

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Avramović, Nataša, Boris Mandić, Ana Savić-Radojević, and Tatjana Simić. "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy." Pharmaceutics 12, no. 4 (2020): 298. http://dx.doi.org/10.3390/pharmaceutics12040298.

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Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget c

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Mishra, Vijay, Kuldeep Bansal, Asit Verma, et al. "Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems." Pharmaceutics 10, no. 4 (2018): 191. http://dx.doi.org/10.3390/pharmaceutics10040191.

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Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication

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Tsai, Cheng-Han, Peng-Yuan Wang, I.-Chan Lin, Hu Huang, Guei-Sheung Liu, and Ching-Li Tseng. "Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application." International Journal of Molecular Sciences 19, no. 9 (2018): 2830. http://dx.doi.org/10.3390/ijms19092830.

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Ocular drug delivery has been a major challenge for clinical pharmacologists and biomaterial scientists due to intricate and unique anatomical and physiological barriers in the eye. The critical requirement varies from anterior and posterior ocular segments from a drug delivery perspective. Recently, many new drugs with special formulations have been introduced for targeted delivery with modified methods and routes of drug administration to improve drug delivery efficacy. Current developments in nanoformulations of drug carrier systems have become a promising attribute to enhance drug retentio

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Begines, Belén, Tamara Ortiz, María Pérez-Aranda, et al. "Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects." Nanomaterials 10, no. 7 (2020): 1403. http://dx.doi.org/10.3390/nano10071403.

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The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications

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Supraja, Bommala, and Saritha Mulangi. "An updated review on pharmacosomes, a vesicular drug delivery system." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 393–402. http://dx.doi.org/10.22270/jddt.v9i1-s.2234.

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Novel drug delivery system mainly consents about achieving the targeted concentration to release the drug at targeted site by using carrier system, altering the structure and microenvironment around the drug. Especially drugs which are having narrow therapeutic window are difficult to formulate, with the advantage of novel drug delivery systems like particulate, polymeric carrier, macromolecular and cellular carriers. They are used to reduce complications as well as release the drug in a determined fusion at targeted site. In vesicular drug delivery system drug binds covalently to the lipid mo

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Severino, Patrícia, Tatiana Andreani, Ana Sofia Macedo, et al. "Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery." Journal of Drug Delivery 2012 (November 24, 2012): 1–10. http://dx.doi.org/10.1155/2012/750891.

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Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix int

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Patil, Vijay, and Asha Patel. "Biodegradable Nanoparticles: A Recent Approach and Applications." Current Drug Targets 21, no. 16 (2020): 1722–32. http://dx.doi.org/10.2174/1389450121666200916091659.

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Biodegradable nanoparticles (NPs) are the novel carriers for the administration of drug molecules. Biodegradable nanoparticles have become popular recently because of their special features such as targeted delivery of drugs, improved bioavailability, and better therapeutic effectiveness to administer the drug at a constant rate. Polymeric NPs are very small-sized polymeric colloidal elements in which a drug of interest may be encapsulated or incorporated in their polymeric network or conjugated or adsorbed on the layer. Various polymers are employed in the manufacturing of nanoparticles, some

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Kumar, Abhishek, and Meenakshi Bharkatiya. "A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 14, no. 1 (2021): 5257–70. http://dx.doi.org/10.37285/ijpsn.2021.14.1.1.

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Oral route has been the most convenient and accepted route of drug delivery. Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic in pharmaceutical field to achieved improved therapeutics advantages. Gastro retentive drug delivery system is novel drug delivery systems which has an upper hand owing to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also improves bioavailability of drugs. Concept of novel drug delivery system arose to overcome the certain a

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Nelemans, Levi Collin, and Leonid Gurevich. "Drug Delivery with Polymeric Nanocarriers—Cellular Uptake Mechanisms." Materials 13, no. 2 (2020): 366. http://dx.doi.org/10.3390/ma13020366.

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Nanocarrier-based systems hold a promise to become “Dr. Ehrlich’s Magic Bullet” capable of delivering drugs, proteins and genetic materials intact to a specific location in an organism down to subcellular level. The key question, however, how a nanocarrier is internalized by cells and how its intracellular trafficking and the fate in the cell can be controlled remains yet to be answered. In this review we survey drug delivery systems based on various polymeric nanocarriers, their uptake mechanisms, as well as the experimental techniques and common pathway inhibitors applied for internalization

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Liu, Yu-Chi, Molly Tzu-Yu Lin, Anthony Herr Cheun Ng, Tina T. Wong, and Jodhbir S. Mehta. "Nanotechnology for the Treatment of Allergic Conjunctival Diseases." Pharmaceuticals 13, no. 11 (2020): 351. http://dx.doi.org/10.3390/ph13110351.

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Allergic conjunctivitis is one of the most common external eye diseases and the prevalence has been increasing. The mainstay of treatment is topical eye drops. However, low bioavailability, low ocular drug penetration, transient resident time on the ocular surface due to tear turnover, frequent topical applications and dependence on patient compliance, are the main drawbacks associated with topical administration. Nanotechnology-based medicine has emerged to circumvent these limitations, by encapsulating the drugs and preventing them from degradation and therefore providing sustained and contr

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Gambaro, Francesco Manlio, Aldo Ummarino, Fernando Torres Andón, Flavio Ronzoni, Berardo Di Matteo, and Elizaveta Kon. "Drug Delivery Systems for the Treatment of Knee Osteoarthritis: A Systematic Review of In Vivo Studies." International Journal of Molecular Sciences 22, no. 17 (2021): 9137. http://dx.doi.org/10.3390/ijms22179137.

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Many efforts have been made in the field of nanotechnology to improve the local and sustained release of drugs, which may be helpful to overcome the present limitations in the treatment of knee OA. Nano-/microparticles and/or hydrogels can be now engineered to improve the administration and intra-articular delivery of specific drugs, targeting molecular pathways and pathogenic mechanisms involved in OA progression and remission. In order to summarize the current state of this field, a systematic review of the literature was performed and 45 relevant studies were identified involving both anima

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Vilos, C., and L. A. Velasquez. "Therapeutic Strategies Based on Polymeric Microparticles." Journal of Biomedicine and Biotechnology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/672760.

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The development of the field of materials science, the ability to perform multidisciplinary scientific work, and the need for novel administration technologies that maximize therapeutic effects and minimize adverse reactions to readily available drugs have led to the development of delivery systems based on microencapsulation, which has taken one step closer to the target of personalized medicine. Drug delivery systems based on polymeric microparticles are generating a strong impact on preclinical and clinical drug development and have reached a broad development in different fields supporting

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Mandracchia, Delia, Adriana Trapani, Sara Perteghella, et al. "A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs." Pharmaceutics 10, no. 3 (2018): 97. http://dx.doi.org/10.3390/pharmaceutics10030097.

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Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) an

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Singh, Ridhima, Vikram Joshi, Nitin Mehetre, and Abhay T. Sangamwar. "Insights into co-amorphous systems in therapeutic drug delivery." Therapeutic Delivery 12, no. 3 (2021): 245–65. http://dx.doi.org/10.4155/tde-2020-0109.

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Co-amorphous (CAM) systems are promising drug-delivery systems in the arena of therapeutic drug delivery, addressing the poor aqueous solubility of drugs by enhancing solubility and thereby improving the oral bioavailability and therapeutic effect of the drug. A CAM system is a single-phase homogeneous blend of two or more low molecular weight molecules that can be drug–drug or drug–co-former, stabilized via intermolecular interactions, adding the benefit of thermodynamic stability. This review covers the fundamentals of CAM systems and recent advances in formulation development. In particular

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Folliero, Veronica, Carla Zannella, Annalisa Chianese, et al. "Application of Dendrimers for Treating Parasitic Diseases." Pharmaceutics 13, no. 3 (2021): 343. http://dx.doi.org/10.3390/pharmaceutics13030343.

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Despite advances in medical knowledge, parasitic diseases remain a significant global health burden and their pharmacological treatment is often hampered by drug toxicity. Therefore, drug delivery systems may provide useful advantages when used in combination with conventional therapeutic compounds. Dendrimers are three-dimensional polymeric structures, characterized by a central core, branches and terminal functional groups. These nanostructures are known for their defined structure, great water solubility, biocompatibility and high encapsulation ability against a wide range of molecules. Fur

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