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Dissertations / Theses on the topic 'Drug delivery systems'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Apps, MIchael Garry. "Platinum anticancer drugs and drug delivery systems." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14409.

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In this thesis two different ways to improve platinum-based chemotherapy were investigated. The first was through the use of a new slow release clay-based drug delivery vehicle and the second through the design and synthesis of novel dinuclear platinum complexes. For the clay-based drug delivery research, the platinum anticancer complex [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)] chloride, PHENSS, was loaded into montmorillonite (MMT) clay. The PHENSS was found to be incompletely burst released from the MMT. The MMT also had a negative effect on the in vitro cytotoxicity of P
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2

Ketkar, Amol Sharad. "Polymeric drug delivery systems /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487859879937796.

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3

Zaher, Amir. "Remotely controlled drug delivery systems." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57611.

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Implantable drug delivery is becoming an increasingly important field of research, providing great potential for a wide range of flexible and low cost solutions for localized treatment of chronically debilitating diseases. This dissertation presents work that encompasses several approaches for the remote triggering, powering, and control of micro drug delivery devices and systems, designed with remote-controllability, minimal power requirements, biocompatibility, and the potential for minimally invasive implantation in mind. The control mechanisms used rely on microtechnology, nanotechnology,
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4

Squire, Marie A. "Protein-based drug delivery systems." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6518.

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The targeted delivery of drugs is one of the most actively pursued goals in anti-HIV and anti-cancer chemotherapy. This project takes a proof-of-concept approach to the development of protein-based drug delivery systems - delivery systems that would package, target, and deliver cytotoxins to diseased cells. Primarily, this project explores the use of the potent anti-HN protein, cyanovirin-N (CV-N), to actively target and deliver cytotoxic natural products to HN-infected cells. This project also investigates the use of human serum albumin (HSA), a 66 kDa protein, as a macromolecular carrier to
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5

Muldoon, B. M. "Mucoadhesive systems for drug delivery." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268336.

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6

Allen, Rosamund Elizabeth. "Liposomes as drug delivery systems." Thesis, University of Essex, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352982.

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7

Liu, Weipeng. "Biopolymer-based ocular drug delivery systems." Diss., Connect to online resource - MSU authorized users, 2008.

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8

Rosenbaum, Erik. "Optical characterization of potential drugs and drug delivery systems." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40177.

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This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. These methods include optical absorption and fluorescence as well as time-resolved fluorescence. Upon covalently linking compounds with high quantum yields of fluorescence to specific parts of the pilicide, the biological impact was found to increase for some of the derivatives. Furthermore, by expanding the aromatic part of
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9

Zhao, Tianjing. "Self-nanoemulsifying drug delivery systems (SNEDDS) for the oral delivery of lipophilic drugs." Doctoral thesis, Università degli studi di Trento, 2015. https://hdl.handle.net/11572/369035.

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The increasing number of lipophilic drug candidates in development in the pharmaceutical industry calls for advanced drug delivery systems with increased bioavailability less day-to-day and food-intake-dependent. Many of these drug candidates possess poor water solubility, so that their dissolution rate in the gastrointestinal tract (GIT) limits their absorption following oral administration. In the past few decades, various lipid-based formulations have been investigated to enhance the bioavailability of such challenging drug candidates and to increase their clinical efficacy when administere
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10

Zhao, Tianjing. "Self-nanoemulsifying drug delivery systems (SNEDDS) for the oral delivery of lipophilic drugs." Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1608/1/Doctoral_thesis-Self-nanoemulsifying_drug_delivery_systems_(SNEDDS)_for_the_oral_delivery_of_lipophilic_drugs-Tianjing_ZHAO.pdf.

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The increasing number of lipophilic drug candidates in development in the pharmaceutical industry calls for advanced drug delivery systems with increased bioavailability less day-to-day and food-intake-dependent. Many of these drug candidates possess poor water solubility, so that their dissolution rate in the gastrointestinal tract (GIT) limits their absorption following oral administration. In the past few decades, various lipid-based formulations have been investigated to enhance the bioavailability of such challenging drug candidates and to increase their clinical efficacy when administer
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11

Qin, Jian. "Environment-Sensitive Multifunctional Drug Delivery Systems." Doctoral thesis, KTH, Funktionella material, FNM, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12053.

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Drug delivery systems (DDS) with multiple functionalities such as environment-sensitive drug release mechanisms and visualization agents have motivated the biomedical community as well as materials chemists for more than a decade. This dissertation is concerned with the development of nanoparticles for multifunctional DDS  to tackle several crucial challenges in these complex systems, including polymeric nanospheres which respond to temperature change, superparamagnetic iron oxide nanoparticles/polymeric composite for magnetic resonance imaging contrast agents and drug carriers, immunoresponse
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12

Qin, Jian. "Nanoparticles for multifunctional drug delivery systems." Licentiate thesis, Stockholm : Kemi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4369.

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13

Campbell, K. C. "Novel systems for transdermal drug delivery." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368758.

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14

Lee, Antony James. "Mathematical modelling of drug delivery systems." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309563.

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15

Udo-Chijioke, Onyinyechi. "Aquasomes : multilayered nanoparticular drug delivery systems." Thesis, Aston University, 2016. http://publications.aston.ac.uk/33399/.

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Nanoparticulate delivery systems have been widely used in recent decades, available in a wide variety of structures, for targeted drug delivery. They provide controlled and prolonged release for drugs, peptides and biopharmaceuticals. Ceramic nanoparticles are one of the various nanocarriers, which have been employed in local targeted delivery, most commonly in the area of orthopaedic drug delivery to enhance treatment therapies. This thesis therefore focused on the development of aquasomes, a ceramic nanoparticulate carrier system, for the delivery of proteins, growth factors and antibiotics
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16

Weaver, Richard. "Polyammonium conjugates as drug delivery systems." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/33980.

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This thesis describes the novel synthesis of eight polyamine-nitrogen mustard conjugates and two polyamine-nitroxide conjugates. The structure-activity relationship of these compounds with DNA has been investigated. The approach started with the regioselective BOC protection of commercially available norspermidine, spermidine and spermine plus the total synthesis of protected polyamines e.g. homospermidine and spermine. The nitrogen mustards chlorambucil and melphalan were conjugated to the polyamines at primary and secondary nitrogens via a variable length amide linkage to give a structural r
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17

Ogden, Dorothy. "Modifiable Hyperbranched Polyester Drug Delivery Systems." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520.

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18

Fei, Dan. "Biodegradable polyanhydrides as drug delivery systems." Thesis, Aston University, 2003. http://publications.aston.ac.uk/10949/.

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Polyanhydrides are useful biodegradable vehicles for controlled drug delivery. In aqueous media the breaking of the anhydride bonds resulting in gradually polymer fragments collapse and release drugs in a controlled manner. In this study, two new biodegradable polyanhydrides copolymers were synthesised using a melt-polycondensation method. The first is poly (bis (p-carboxyphenoxy)-2-butene-co-sebacic acid) (CP2B: SA), which has double bonds along the polymer backbone. The second is crosslinked poly (glutamic acid-sebacic acid-co-sebacic acid) (GluSA: SA), where the conjugated unit of glutamic
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19

Chia, Leonard Sze Onn. "Investigating controlled release pulmonary drug delivery systems." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273209.

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The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved by reducing the number of times drugs need to be administered. In this study, two controlled pulmonary drug delivery systems for drugs of different solubilities were investigated and they were characterised for their viability as effective controlled release pulmonary drug delivery systems, particula
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20

Mawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.

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Introduction: Embolic agents are used to block blood flow of hypervascular tumours, ultimately resulting in target tissue necrosis. However, this therapy is limited by the formation of new blood vessels within the tumour, a process known as angiogenesis. Targeting angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an embolic agent for delivery of macromolecular drugs
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21

Mahaguna, Vorapann. "Investigation of cellulose ether polymers in controlled drug delivery." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037524.

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22

Jørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.

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23

Yang, Xiaojuan. "Development of Nanoparticle Systems for Therapeutic Drug Delivery." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1248972068.

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24

Zderic, Vesna. "Ultrasound-enhanced ocular drug delivery /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8085.

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25

Baki, Mert. "Bone Marrow Targeted Liposomal Drug Delivery Systems." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613251/index.pdf.

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Homing is the process that stem cells move to their own stem cell niches under the influence of chemokines like stromal-derived factor-1&alpha<br>(SDF-1&alpha<br>) upon bone marrow transplantation (BMT). There is a need for increasing homing efficiency after BMT since only 10-15% of the transplanted cells can home to their own niches and a limited amount of donor marrow can be transplanted. In this study, we aimed to develop and characterize bone marrow targeted liposomal SDF-1&alpha<br>delivery system prepared by extrusion method. Alendronate conjugation was chosen to target the liposomes to
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26

Zaid, Alkilani Ahlam. "Polymeric microneedle systems for transdermal drug delivery." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603301.

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Delivery across skin offers many advantages compared to oral or parenteral routes e.g. non-invasive, avoiding first-past metabolism, improved bioavailability and reduction of systemic side effects. Microneedle (MN) are minimally-invasive devices that painlessly by-pass the skin's stratum corneum, which is the principal barrier to topically-applied drugs. Polymeric MN delivery systems were designed and evaluated to transdermally deliver two model drugs, the small water soluble drug ibuprofen sodium and the large protein ovalbumin (OVA). A range of hydrogel forming materials for MN production wa
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27

Lawlor, Michelle S. "Rheological characterisation of bioadhesive drug delivery systems." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326370.

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28

Berwick, James Miles. "Surface-engineered biomimetic systems for drug delivery." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416292.

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29

Zhang, Huizhen. "Liposome drug delivery systems for anticancer agents." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/711.

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Development of liposome formulation of an amphiphilic anticancer peptide using the ANTS/DPX leakage assay. The effects of lipid composition on the liposomes' resistance to an amphiphilic cyclic peptide c[KS.S.S.KWL W] were studied by the ANTS/DPX leakage assay. One or more unsaturated acyl chains in the phospholipids, small phospholipid headgroup size, the presence of cholesterol, and the presence of PEG-lipid were demonstrated as critical parameters to stabilize the liposome membrane. A liposome formulation of the peptide comprising POPE/POPC/cholesterol/C16 mPEG 2000 ceramide (20.8:31.2:40:8
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30

McMillan, Hannah Louise. "Sustained release biodegradable ocular drug delivery systems." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678216.

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Delivery of drugs to the posterior segment of the eye is notoriously difficult and unfortunately many chronic conditions of the posterior segment often lead to sight-loss if not treated effectively. Current methods of delivery such as topical drops result in poor bioavailability at the back of the eye, while the blood brain retina imposes restrictions on the entry on drugs into the eye delivered by the systemic system. The gold-standard method for delivery of therapeutic concentrations of drugs is intravitreal delivery, which involves an injection into the vitreous cavity. Although this provid
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31

He, Xingyu. "Long-term Light-activated Drug Delivery Systems." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613752062550859.

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32

Huang, Tien-Lu. "Oscillating Aqueous Gels as Drug Delivery Systems." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366066532.

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33

Sutton, Damon Michael. "PH SENSITIVE RNA AND DRUG DELIVERY SYSTEMS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1179847644.

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34

Yung, Bryant Chinung. "NANOPARTICLE DRUG DELIVERY SYSTEMS FOR CANCER THERAPY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417614665.

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35

Senderoff, Richard I. "Development of fibrin-based drug delivery systems /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267728699.

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36

Giglio, Valentina. "Biofunctionalized systems for drug discovery and delivery." Doctoral thesis, Università di Catania, 2016. http://hdl.handle.net/10761/3893.

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During this doctoral research work new potential drug delivery vehicles for targeted treatment of cancers were developed. For this purpose, both soft and hard materials were subject of study. Firstly, the synthesis, the characterization and the biological evaluation of monomeric â-cyclodextrins functionalized with folic acid (FA) were the focus of this research. In particular, four new conjugates (CyD-FAs), both 3- and 6-functionalized â-CyDs (â-CyD3 and â-CyD6) linked to the á- or ã-carboxylic group of the FA were synthesized, isolated and fully characterized. Furthermore, the ability of thes
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37

Al-Kassas, Raida. "Design of particulate delivery systems." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239000.

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38

Park, Jung-Hwan. "Polymeric microneedles for transdermal drug delivery." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131324/unrestricted/park%5Fjung-hwan%5F200405%5Fphd.pdf.

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39

Javaheri, Hoda. "Wet granulated liquisolid drug delivery systems with hydrophobic and hydrophilic drugs." Thesis, University of Sunderland, 2017. http://sure.sunderland.ac.uk/8549/.

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The formulation of hydrophobic drugs into appropriate dosage forms is challenging due to the problems associated with those drugs such as low solubility and poor dissolution. Using a liquisolid system is a promising method to improve the dissolution of hydrophobic drugs and in sustaining the release of hydrophilic drugs, in which solid drugs are dispersed in non-volatile liquid vehicles. The aim of this research was to use the liquisolid technique to enhance the dissolution rate of glibenclamide, a model hydrophobic drug, and to sustain the release of metformin-HCl, as a model hydrophilic drug
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40

MIELE, DALILA. "NANOPARTICLES AND NANOFIBERS AS DRUG DELIVERY SYSTEMS OF POORLY SOLUBLE DRUGS." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1321848.

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La via sistemica rappresenta la scelta più comune per la somministrazione di attivi e per lottenimento delleffetto terapeutico. Ad essa sono associate una serie di limitazioni tra cui la distribuzione aspecifica del farmaco responsabile della scarsa efficacia terapeutica e degli effetti collaterali che si tramutano in effetti tossici su siti differenti dal bersaglio terapeutico. Per questo motivo, vie di somministrazione a rilascio locale hanno di recente attratto la ricerca scientifica nel formulare sistemi in grado di veicolare lagente terapeutico su cellule o tessuti specifici; tale operazi
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41

Lungare, Shital. "Development of novel delivery systems for nose-to-brain drug delivery." Thesis, Aston University, 2017. http://publications.aston.ac.uk/37491/.

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The blood brain barrier (BBB) poses a significant hurdle to brain drug delivery. However, the location of the olfactory mucosa, within the nasal cavity, is a viable target site for direct nose-to-brain (N2B) delivery, thereby bypassing the BBB. To exploit this target site innovative nasal formulations are required for targeting and increasing residency within the olfactory mucosa. We developed and characterised three formulation systems for N2B delivery, (i) thermoresponsive mucoadhesion nasal gels sprays; (ii) mesoporous silica nanoparticles and (iii) nasal pMDI devices. We developed an optim
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42

Forbes, Zachary Graham Barbee Kenneth A. "Magnetizable implants for targeted drug delivery /." Philadelphia, Pa. : Drexel University, 2005. http://dspace.library.drexel.edu/handle/1860/472.

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43

Zhang, Qilei. "NMR and MRI studies of controlled release drug delivery systems." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610886.

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44

Triplett, Michael David. "Enabling solid lipid nanoparticle drug delivery technology by investigating improved production techniques." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1101830018.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 172 p.; also includes graphics (some col.). Includes bibliographical references (p. 161-172).
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45

Kansara, Viral Mitra Ashim K. "Ocular delivery of peptide ganciclovir prodrugs following subconjunctival injection evaluation of episcleral drug delivery approach /." Diss., UMK access, 2007.

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Thesis (Ph. D.)--School of Pharmacy. University of Missouri--Kansas City, 2007.<br>"A dissertation in pharmaceutical sciences and pharmacology." Advisor: Ashim K. Mitra. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed May 23, 2008. Includes bibliographical references (leaves 210-225). Online version of the print edition.
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46

Lanz, Landázuri Alberto. "Modification of microbial polyacids for drug delivery systems." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/134511.

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Polymers are becoming preferred materials in biomedical applications because of their vast diversity of properties, functionalities and applications. Properties as mechanical strength, stability against degradation, biocompatibility and biodegradability, among others, have been attractive for different medical applications. One of the most interesting applications of these materials is drug delivery systems. Biodegradable polymers and copolymers are the preferred materials for the manufacture of a variety of devices for temporal applications in medicine and pharmacology; these biodegradable p
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47

Atakan, Aylin. "Mesoporous material systems for catalysis and drug delivery." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2018. http://hdl.handle.net/10803/668659.

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This study evolved to its last form primarily around the development of a hybrid material is the core of the work. This hybrid material is then further explored for two different applications which are catalysis and drug delivery. A nanoassembly was established around a mesoporous silica support. SBA-15 was picked as this support among the other mesoporous silica dueto its well-defined pore structure and accessible pore volume. The silica framework was doped with Zr-atoms and the pores partly infiltrated with Cu nanoparticles resulting in a hybrid material with tunable properties. SBA-15 was
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48

Zong, Jingyi. "The development of anti-cancer drug delivery systems." Thesis, Durham University, 2016. http://etheses.dur.ac.uk/11927/.

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Cancer is undoubtedly one of the main threats to global human health and as a result, despite significant advances in the field, new and improved cancer treatments are still in great need. Although chemotherapy (in combination with other therapies) is widely used to suppress the growth of tumours, many of the current anti-cancer drugs suffer from poor selectivity and consequently severe toxicity. In order to conquer these limitations, targeted drug delivery systems have been designed and studied with the primary aim of improving the accuracy of transporting anti-cancer drugs into cancer cells
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49

Murty, Aruna Mummini. "Evaluation of potential multi-particulate drug delivery systems /." View online ; access limited to URI, 2006. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3225324.

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50

Sample, Ian Robert. "Soft acrylic resins as potential drug delivery systems." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246772.

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