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Journal articles on the topic 'Drug delivery systems'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sharma, Abhimanyu Rai, Binu Raina, Prabhjot Singh Bajwa, Pankaj Sharma, Anurag Bhargava, and Shailesh Sharma. "Chronotherapeutic drug delivery systems." Asian Pacific Journal of Health Sciences 5, no. 2 (2018): 189–95. http://dx.doi.org/10.21276/apjhs.2018.5.2.36.

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2

Langer, Robert. "Drug Delivery Systems." MRS Bulletin 16, no. 9 (1991): 47–49. http://dx.doi.org/10.1557/s0883769400056050.

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For many years, drug delivery systems were composed of simple pills, eyedrops, ointments, or intravenous solutions. Recently, materials have begun to play a major role in improving drug delivery. Drugs are now chemically attached to polymers, entrapped in small vesicles that are injected into the bloodstream, or put in pumps or polymeric materials that are placed in the body. These new materials-based systems are beginning to change the way drugs can be administered and, in so doing, have improved human health. This article provides a brief review of the major classes of drug delivery systems;

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3

K Purushotham and K Anie Vijetha. "A review on transdermal drug delivery system." GSC Biological and Pharmaceutical Sciences 22, no. 2 (2023): 245–55. http://dx.doi.org/10.30574/gscbps.2023.22.2.0053.

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In order to produce systemic effects, transdermal drug delivery systems (TDDS), commonly referred to as "patches," are dosage forms that are intended to spread a therapeutically active amount of medicine across the skin of a patient. Drugs that are applied topically are delivered using transdermal drug delivery devices. These are pharmaceutical preparations of varying sizes, containing one or more active ingredients, intended to be applied to the unbroken skin in order to deliver the active ingredient after passing through the skin barriers, and these avoid first pass metabolism. Today about 7

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4

K, Purushotham, and Anie Vijetha K. "A review on transdermal drug delivery system." GSC Biological and Pharmaceutical Sciences 22, no. 2 (2023): 245–55. https://doi.org/10.5281/zenodo.7919611.

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In order to produce systemic effects, transdermal drug delivery systems (TDDS), commonly referred to as "patches," are dosage forms that are intended to spread a therapeutically active amount of medicine across the skin of a patient. Drugs that are applied topically are delivered using transdermal drug delivery devices. These are pharmaceutical preparations of varying sizes, containing one or more active ingredients, intended to be applied to the unbroken skin in order to deliver the active ingredient after passing through the skin barriers, and these avoid first pass metabolism. Tod

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5

Berillo, Dmitriy, Adilkhan Yeskendir, Zharylkasyn Zharkinbekov, Kamila Raziyeva, and Arman Saparov. "Peptide-Based Drug Delivery Systems." Medicina 57, no. 11 (2021): 1209. http://dx.doi.org/10.3390/medicina57111209.

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Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective t

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6

V., T. Iswariya. "Bioelectronic systems in controlled drug delivery systems- A novel dosage form." International Journal of Biosciences (IJB) 24, no. 4 (2024): 149–59. https://doi.org/10.12692/ijb/24.4.149-159.

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Electronic drug delivery systems (EDDS) are an interesting advancement in drug delivery technology. They are portable, interactive, wirelessly networked, and enable patient-administered medication, which lowers overall healthcare costs. Controlled DDS maintains drug plasma levels constantly by releasing the definite dose of the drug at each time point for a predetermined duration. This helps in reducing the dose and dosing frequency and improves patient compliance. Lesser drug exposure to the biological environment reduces drug toxicity and adverse effects. Among controlled release. Transderma

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7

Mali, Audumbar Digambar, Ritesh Bathe, and Manojkumar Patil. "An updated review on transdermal drug delivery systems." International Journal of Advances in Scientific Research 1, no. 6 (2015): 244. http://dx.doi.org/10.7439/ijasr.v1i6.2243.

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Transdermal drug delivery systems (TDDS), also known as patches, are dosage forms designed to deliver a therapeutically effective amount of drug across a patients skin. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of

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8

Chavhan, Sarin A., Sushilkumar A. Shinde, Sandip B. Sapkal, and Vinayak N. Shrikhande. "Herbal excipients in Novel Drug Delivery Systems." International Journal of Research and Development in Pharmacy & Life Sciences 6, no. 3 (2017): 2597–605. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(3).2597-2605.

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9

Ranade, Vasant V. "Drug Delivery Systems 5A. Oral Drug Delivery." Journal of Clinical Pharmacology 31, no. 1 (1991): 2–16. http://dx.doi.org/10.1002/j.1552-4604.1991.tb01881.x.

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10

Ranade, Vasant V. "Drug Delivery Systems. 6. Transdermal Drug Delivery." Journal of Clinical Pharmacology 31, no. 5 (1991): 401–18. http://dx.doi.org/10.1002/j.1552-4604.1991.tb01895.x.

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11

Ranade, Vasant V. "Drug Delivery Systems 5B. Oral Drug Delivery." Journal of Clinical Pharmacology 31, no. 2 (1991): 98–115. http://dx.doi.org/10.1002/j.1552-4604.1991.tb03693.x.

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12

Gubba, Laxmi, Sagarika Laxmi Gujjuri, Sathwika Reddy Gullapalli, Veeru Gugulothu, and Bhaskar Jimidi. "A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEMS." World Journal of Pharmaceutical Science and Research 4, no. 3 (2025): 103–13. https://doi.org/10.5281/zenodo.15561434.

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Transdermal drug delivery is the most commonly used for topical delivery of a drug. It is a painless method of delivering drugs to the targeted organ. It is a best way to enhance the bioavailability of the drug at the site. Transdermal drug delivery aims for systemic effects by controlling the release of drug into the blood stream. This paper gives a brief information of transdermal drug delivery and explains how the drug enters into the systemic circulation. Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution. E

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13

Polack, Alan, and Michael Roberts. "Drug delivery systems." Medical Journal of Australia 144, no. 6 (1986): 311–14. http://dx.doi.org/10.5694/j.1326-5377.1986.tb128383.x.

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14

Davis, S. S. "Drug delivery systems." Interdisciplinary Science Reviews 25, no. 3 (2000): 175–83. http://dx.doi.org/10.1179/030801800679206.

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15

Roberts, M. S. "Drug‐delivery systems." Medical Journal of Australia 150, no. 9 (1989): 522. http://dx.doi.org/10.5694/j.1326-5377.1989.tb136612.x.

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16

Erdine, Serdar, and Jose De Andres. "Drug Delivery Systems." Pain Practice 6, no. 1 (2006): 51–57. http://dx.doi.org/10.1111/j.1533-2500.2006.00059.x.

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17

Robinson, Dennis H., and John W. Mauger. "Drug delivery systems." American Journal of Health-System Pharmacy 48, no. 10_suppl (1991): S14—S23. http://dx.doi.org/10.1093/ajhp/48.10_suppl_1.s14.

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18

Somberg, J. "Drug Delivery Systems." American Journal of Therapeutics 11, no. 2 (2004): 154. http://dx.doi.org/10.1097/00045391-200403000-00011.

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19

NIKANDER, KURT. "Drug Delivery Systems." Journal of Aerosol Medicine 7, s1 (1994): S—19—S—24. http://dx.doi.org/10.1089/jam.1994.7.suppl_1.s-19.

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20

Pazdernik, Thomas L. "DRUG DELIVERY SYSTEMS." Shock 30, no. 3 (2008): 339. http://dx.doi.org/10.1097/01.shk.0000286298.94327.b3.

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21

Branno-Peppas, Lisa. "Drug delivery systems." Biomaterials 18, no. 5 (1997): 449. http://dx.doi.org/10.1016/s0142-9612(97)85703-1.

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22

Mathiowitz, Edith. "Drug Delivery Systems." Toxicologic Pathology 36, no. 1 (2008): 16–20. http://dx.doi.org/10.1177/0192623307311411.

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23

Pandey, Parijat, Manisha Saini, and Neeta . "Mucoadhesive drug delivery system: an overview." Pharmaceutical and Biological Evaluations 4, no. 4 (2017): 183. http://dx.doi.org/10.26510/2394-0859.pbe.2017.29.

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The major objective of any dosage form is to deliver an optimum therapeutic amount of active agent to the proper site in the body to attain constant & maintenance of the desired drug concentration. Mucoadhesive drug delivery systems are effective delivery systems with various advantages as compared to other oral controlled release dosage forms in terms of drug delivery at specific sites with prolonged retention time of drugs at target sites. The main advantage of these systems includes avoiding first pass metabolism of the drugs and hence availability of high drug concentration at target s

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24

Ma, Zhiyuan, Baicheng Li, Jie Peng, and Dan Gao. "Recent Development of Drug Delivery Systems through Microfluidics: From Synthesis to Evaluation." Pharmaceutics 14, no. 2 (2022): 434. http://dx.doi.org/10.3390/pharmaceutics14020434.

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Conventional drug administration usually faces the problems of degradation and rapid excretion when crossing many biological barriers, leading to only a small amount of drugs arriving at pathological sites. Therapeutic drugs delivered by drug delivery systems to the target sites in a controlled manner greatly enhance drug efficacy, bioavailability, and pharmacokinetics with minimal side effects. Due to the distinct advantages of microfluidic techniques, microfluidic setups provide a powerful tool for controlled synthesis of drug delivery systems, precisely controlled drug release, and real-tim

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25

Narinder, Singh* Pooja Devi Muskan Sharma Naval Singh. "Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 434–46. https://doi.org/10.5281/zenodo.15334655.

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The advancement of pharmaceutical sciences has led to the development of various novel drug delivery systems (NDDS) that improve the efficacy, safety, and patient compliance of therapeutic agents. Traditional drug administration methods often encounter challenges such as poor bioavailability, non-specific distribution, and the need for frequent dosing. To overcome these limitations, several innovative approaches have been explored. Transdermal drug delivery systems (TDDS) allow for sustained drug release through the skin, bypassing first-pass metabolism. Vesicular drug delivery systems (VDDS),

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26

Gauri, R. Dhamale1 Harshali L. Shelke2 Priti B. Shinde3 Rohini R. Khedkar4 Preeti P. Rohokale5 Dr. Jeevan R. Rajguru6. "Gastroretentive Drug Delivery Systems." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1825–40. https://doi.org/10.5281/zenodo.12818744.

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The aim of this review on gastroretentive drug delivery systems is to gather and present recent literature, particularly highlighting the various gastroretentive methods that have recently emerged as prominent techniques in the realm of site-specific, orally administered, controlled release drug delivery. Floating drug delivery systems represent advanced technology that allows these systems to float on gastric fluids, potentially enhancing the bioavailability and intestinal absorption of encapsulated drugs. The effectiveness of these systems depends on both physio

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27

Batur, Eslim, Samet Özdemir, Meltem Ezgi Durgun, and Yıldız Özsoy. "Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery." Pharmaceuticals 17, no. 4 (2024): 511. http://dx.doi.org/10.3390/ph17040511.

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Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for oc

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28

Rao, Tadikonda Rama, Billa Sravani, and Ratnapuram Aarthi. "Nanocarriers in Drug Delivery Systems: An Overview." Journal of Advanced Scientific Research 16, no. 03 (2025): 8–14. https://doi.org/10.55218/jasr.2025160302.

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Nanocarriers have emerged as a transformative technology in drug delivery systems (DDS), offering significant advancements over traditional methods. This review delves into the various types of nanocarriers, including liposomes, polymeric nanoparticles, micelles, dendrimers, and solid lipid nanoparticles, highlighting their unique properties and advantages in targeted drug delivery. Liposomes have demonstrated extraordinary effectiveness in clinical applications due to their biocompatibility. Conversely, polymeric nanoparticles offer improved stability and regulated drug release, which makes t

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29

Sudhakar, Dr Uma, K. Ruth Gethsie, H. Priyanka, and SS Fathima Zinneerah. "Local drug delivery drugs and systems." International Journal of Applied Dental Sciences 6, no. 4 (2020): 70–73. http://dx.doi.org/10.22271/oral.2020.v6.i4b.1047.

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30

Davies, M. "Polymeric Drugs and Drug Delivery Systems." Biomaterials 14, no. 3 (1993): 239. http://dx.doi.org/10.1016/0142-9612(93)90033-x.

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31

Martini, Alessandro, and Cristina Ciocca. "Drug delivery systems for cancer drugs." Expert Opinion on Therapeutic Patents 13, no. 12 (2003): 1801–7. http://dx.doi.org/10.1517/13543776.13.12.1801.

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32

Kennedy, John F., and Giampiero Pagliuca. "Polymeric Drugs and Drug Delivery Systems." Carbohydrate Polymers 18, no. 4 (1992): 311–12. http://dx.doi.org/10.1016/0144-8617(92)90098-b.

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33

Ejike Innocent Nwankwo, Ebube Victor Emeihe, Mojeed Dayo Ajegbile, Janet Aderonke Olaboye, and Chukwudi Cosmos Maha. "Innovative drug delivery methods for combating antimicrobial resistance." International Medical Science Research Journal 4, no. 8 (2024): 834–58. http://dx.doi.org/10.51594/imsrj.v4i8.1454.

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Antimicrobial resistance (AMR) poses a significant threat to global health, complicating the treatment of infectious diseases and leading to increased morbidity and mortality. Innovative drug delivery methods are emerging as critical strategies to combat AMR by enhancing the efficacy of existing antibiotics and facilitating the development of new therapeutic approaches. This paper explores the role of novel drug delivery systems in addressing AMR challenges. One of the primary approaches is the development of targeted drug delivery systems that improve the precision of antibiotic therapy. Nano

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34

Ranade, Vasant V. "Drug Delivery Systems 4. Implants in Drug Delivery." Journal of Clinical Pharmacology 30, no. 10 (1990): 871–89. http://dx.doi.org/10.1002/j.1552-4604.1990.tb03566.x.

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35

Shrestha, Hina, Rajni Bala, and Sandeep Arora. "Lipid-Based Drug Delivery Systems." Journal of Pharmaceutics 2014 (May 19, 2014): 1–10. http://dx.doi.org/10.1155/2014/801820.

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The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations

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36

Wang, Ye, Yongsheng Wei, Hui Liao, et al. "Plant Exosome-like Nanoparticles as Biological Shuttles for Transdermal Drug Delivery." Bioengineering 10, no. 1 (2023): 104. http://dx.doi.org/10.3390/bioengineering10010104.

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Exosomes act as emerging transdermal drug delivery vehicles with high deformability and excellent permeability, which can be used to deliver various small-molecule drugs and macromolecular drugs and increase the transdermal and dermal retention of drugs, improving the local efficacy and drug delivery compliance. At present, there are many studies on the use of plant exosome-like nanoparticles (PELNVs) as drug carriers. In this review, the source, extraction, isolation, and chemical composition of plant exosomes are reviewed, and the research progress on PELNVs as drug delivery systems in trans

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37

He, Wentian. "Enhancing Drug Delivery Systems: Pegylated Drug delivery and Nanoparticle Aided Drug Delivery." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 505–6. http://dx.doi.org/10.22270/jddt.v9i3.2667.

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38

Nadigoti, Jagadeesh, and Shayeda. "Floating Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 595–604. http://dx.doi.org/10.37285/ijpsn.2009.2.3.2.

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Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. Multiple unit FDDS avoid “all-or-nothing” gastric emptying nature

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39

Parmar, Ramesh D., Rajesh K. Parikh, G. Vidyasagar, Dhaval V. Patel, Chirag J. Patel, and Biraju D. Patel. "Pulsatile Drug Delivery Systems: An Overview." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 605–14. http://dx.doi.org/10.37285/ijpsn.2009.2.3.3.

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Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single- an

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40

Jaswinder, Singh *. "LIPID NANOPARTICULATE DRUG DELIVERY SYSTEMS." Journal of Pharma Research 8, no. 8 (2019): 557–63. https://doi.org/10.5281/zenodo.3374087.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>olloidal particles of size range between 10 and 1000 nm are known as nanoparticles. Over the last few years, lipid based drug delivery systems such as solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) and lipid drug conjugate (LDC) have become the most promising drug delivery systems. Each preparation of the lipid based nanoparticles has advantages and disadvantages with respect to specific characteristics. The SLN is an excellent drug delivery system and has extensive prospects in the pharmaceutical field. N

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41

Demchuk, Zoriana, Mariya Savka, Andriy Voronov, Olga Budishevska, Volodymyr Donchak, and Stanislav Voronov. "Amphiphilic Polymers Containing Cholesterol for Drug Delivery Systems." Chemistry & Chemical Technology 10, no. 4s (2016): 561–70. http://dx.doi.org/10.23939/chcht10.04si.561.

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The interaction of binary copolymers poly(maleic anhydride-co-poly(ethylene glycol) methyl ether methacrylate) with cholesterol results in formation of cholesterol containing polymers, which contain from 4.6 to 46.0 mol % monocholesteryl maleic links. Their structure was confirmed using functional analysis and IR spectroscopy. Acidic and anhydride links of these copolymers form polymeric salts if react with alkali. These salts are surfactants which in aqueous medium form a hierarchy micelles and micellar aggregates depending on the copolymer concentration. Using conductometry it was found that

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42

Ng, Jaryl Chen Koon, Daniel Wee Yee Toong, Valerie Ow, et al. "Progress in drug-delivery systems in cardiovascular applications: stents, balloons and nanoencapsulation." Nanomedicine 17, no. 5 (2022): 325–47. http://dx.doi.org/10.2217/nnm-2021-0288.

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Drug-delivery systems in cardiovascular applications regularly include the use of drug-eluting stents and drug-coated balloons to ensure sufficient drug transfer and efficacy in the treatment of cardiovascular diseases. In addition to the delivery of antiproliferative drugs, the use of growth factors, genetic materials, hormones and signaling molecules has led to the development of different nanoencapsulation techniques for targeted drug delivery. The review will cover drug delivery and coating mechanisms in current drug-eluting stents and drug-coated balloons, novel innovations in drug-elutin

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43

Karmakar, Shaswata, Shashikiran Shanmugasundaram, and Baishakhi Modak. "Oleogel-based drug delivery for the treatment of periodontitis: current strategies and future perspectives." F1000Research 12 (September 27, 2023): 1228. http://dx.doi.org/10.12688/f1000research.140173.1.

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Periodontitis is the chronic inflammation of tooth-supporting tissues that leads to loss of tooth support if untreated. Conventional therapy for periodontitis (mechanical removal of microbial biofilm and oral hygiene enforcement) is augmented by anti-microbial and anti-inflammatory drugs. These drugs are frequently delivered locally into the periodontal pocket for maximum efficiency and minimum adverse effects. The potential of oleogels for periodontal drug delivery has been discussed and further, the future scope of oleogel-based drug delivery systems in dentistry. An oleogel-based local drug

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44

Samuel, Humphrey, Gideon Okibe, Manasseh Ilumunter, Undie David, Esther Omeche, and Fatima Mahmud. "Applications of Nanotechnology in Drug Delivery Systems." Baghdad Journal of Biochemistry and Applied Biological Sciences 5, no. 3 (2024): 162–80. https://doi.org/10.47419/bjbabs.v5i3.295.

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Nanotechnology offers a revolutionary approach to drug delivery systems, with nanoparticles playing a central role. These particles, typically sized between 1 and 100 nanometers, possess unique properties that enhance medication effectiveness and reduce side effects. This article explores the key applications of nanotechnology in drug delivery. The ability to deliver drugs directly to target sites is a significant advantage. Nanoparticles can be engineered to navigate biological barriers and reach specific cells or tissues, minimizing damage to healthy areas. This targeted approach is particul

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45

Vaishnavi S. Mukhmale, Sakshi Y. Patrikar, Nandkishor B. Deshmukh, and Swati P. Deshmukh. "Implantable drug delivery systems: An overviews." GSC Advanced Research and Reviews 22, no. 1 (2025): 123–32. https://doi.org/10.30574/gscarr.2025.22.1.0002.

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Implant are sterile solid mass that contains medicine, prepared by different ways like extrusion, moulding or contraction. The conventional routes of medicine administration has limited control over medicine release and maintaining constant tube remedial medicine attention for longer ages of time. To avoid these problems associated with application of traditional lozenge forms, there was essential need for development of new lozenge forms which would discharge medicines at controlled rate for original exertion. This led to enhancement of Novel Drug Delivery Systems (NDDS) that offers optimisat

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46

Nguyen, Thi-Thao-Linh, and Van-An Duong. "Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery." Pharmaceuticals 18, no. 5 (2025): 615. https://doi.org/10.3390/ph18050615.

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In recent decades, nose-to-brain drug delivery has shown effectiveness in treating many central nervous system diseases. Intranasally administered drugs can be delivered to the brain through the olfactory and trigeminal pathways that bypass the blood–brain barrier. However, nose-to-brain drug delivery is challenging due to the inadequate nasal mucosa absorption of drugs and the short retention time of the intranasal formulations. These problems can be minimized through the use of nano-drug delivery systems, such as micelles, polymeric nanoparticles, nanoemulsions, liposomes, solid lipid nanopa

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47

Rohini U, Sante, Ajay Fugate, Priyanka D. Yelkote, et al. "A Review on Transdermal Drug Delivery System." Asian Journal of Pharmaceutical Research and Development 12, no. 2 (2024): 77–86. http://dx.doi.org/10.22270/ajprd.v12i2.1365.

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Transdermal patches are designed to deliver drugs across the skin membrane without causing pain. This method of drug delivery, known as transdermal delivery, was first used in 1981 when Ciba-Geigy smarketed Transdermal V (now marketed as Transderm Scop) to prevent nausea and vomiting associated with motion sickness. Transdermal patches are pharmaceutical preparations of varying sizes, containing one or more active ingredients, which are applied to unbroken skin to deliver the active ingredient after passing through the skin barriers, thus avoiding first-pass metabolism. Today, about 74% of dru

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48

RK, Gunda. "Transdermal Drug Delivery System: An Emphasis on Transdermal Patches." Pharmaceutical Drug Regulatory Affairs Journal 6, no. 1 (2023): 1–5. http://dx.doi.org/10.23880/pdraj-16000147.

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Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, i.v., i.m., etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir

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49

Chawra, Himmat Singh, Y. S. Tanwar, Ritu M. Gilhotra, and S. K. Singh. "Gastroretentive drug delivery systems a potential approach for antihypertensive drugs: An updated review." Asian Pacific Journal of Health Sciences 5, no. 2 (2018): 217–23. http://dx.doi.org/10.21276/apjhs.2018.5.2.40.

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50

Kundan Rajendra Mahajan, Ashish Prakash Gorle, and Vijay Sanjay Khalane. "Overview on pulsatile drug delivery system." International Journal of Science and Research Archive 5, no. 2 (2022): 110–18. http://dx.doi.org/10.30574/ijsra.2022.5.2.0067.

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Abstract:

Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal

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