Relevant bibliographies by topics / Drug-Drug Cocrystal

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Academic literature on the topic 'Drug-Drug Cocrystal'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Drug-Drug Cocrystal"

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Ul Islam, Noor, Ezzat Khan, Muhammad Naveed Umar, et al. "Enhancing Dissolution Rate and Antibacterial Efficiency of Azithromycin through Drug-Drug Cocrystals with Paracetamol." Antibiotics 10, no. 8 (2021): 939. http://dx.doi.org/10.3390/antibiotics10080939.

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Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile. Nowadays pharmaceutical industries are focused on preparing drug-drug cocrystals of APIs that are often prescribed in combination therapies by physicians. Physicians normally prescribe antibiotic with an analgesic/antipyretic drug to combat several ailments in a better and more efficient way. In this work, azithromycin (AZT) and paracetamol (PCM) cocrystals were prepared in 1:1 molar ratio using slow solvent evaporation method.
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Tamang, Rejoys, Ammon Tamang, and Sayani Bhattacharyya. "Formulation and evaluation of orodispersible tablet of dolutegravir -methionine cocrystal." Fabad Journal of Pharmaceutical Sciences 50, no. 1 (2025): 1–14. https://doi.org/10.55262/fabadeczacilik.1516443.

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Dolutegravir, a newly approved anti-HIV medication is insoluble in the normal gastric pH range and that results in slow onset of action. The research proposes cocrystallization process to increase the solubility of the drug and hence dissolution. The cocrystals of dolutegravir were formulated using methionine as coformers by solvent evaporation method. The cocrystals were evaluated for solubility, in vitro drug release, and solid-state characterization, study. The orodispersible tablets of dolutegravir cocrystal were successfully prepared by direct compression method. The solid-state character
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Bhalekar, Mangesh, and Sumedh Bandu Pradhan. "Scientific Coformer Screening, Preparation and Evaluation of Fenofibrate Tartaric Acid Cocrystal." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 406–10. http://dx.doi.org/10.22270/jddt.v9i4.3199.

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Objective: This present study aims to screen pharmaceutical cocrystal of Fenofibrate and coformers. Further the preparation and evaluation of fenofibrate-coformer cocrystal and In-Vitro drug release and Ex-Vivo Permeation study was done. Material and Methods: The coformers for Fenofibrate were screened using molecular docking. The cocrystals produced were characterized using Differential Scanning Calorimetry (DSC), X-ray diffraction (XRPD) study and Infrared spectroscopy. Results: Cocrystal of Fenofibrate with tartaric acid was successfully prepared. The cocrystals displayed enhanced dissoluti
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P. Ahirrao, Sapana, Mayur P. Sonawane, Deepak S. Bhambere, et al. "Cocrystal Formulation: A Novel Approach to Enhance Solubility and Dissolution of Etodolac." Biosciences Biotechnology Research Asia 19, no. 1 (2022): 111–19. http://dx.doi.org/10.13005/bbra/2971.

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Etodolac (ETD) is a non-steroidal anti-inflammatory drug (NSAID) given in rheumatoid arthritis treatment. As it comes under BCS class II drug hence it exhibits low water solubility. Also, its dissolution rate-limited oral absorption results in delayed onset of action. The Novel approach in the solubility enhancement field; crystal engineering was preferred to prepare pharmaceutical cocrystals of etodolac with GRAS (generally recognized as safe) molecules. Pharmaceutical cocrystals of etodolac were prepared with p-hydroxybenzoic acid and glutaric acid with the drug: coformer ratio 1:1 and 1:2.
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Gohel, Sunil Kumar, Vasanthi Palanisamy, Palash Sanphui, Muthuramalingam Prakash, Girij Pal Singh, and Vladimir Chernyshev. "Isostructural cocrystals of metaxalone with improved dissolution characteristics." RSC Advances 11, no. 49 (2021): 30689–700. http://dx.doi.org/10.1039/d1ra05959a.

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Metaxalone forms isostructural cocrystals with nicotinamide and salicylamide that offer a solubility advantage compared to the native drug. A drug–drug homosynthon is retained in all the cocrystal structures.
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Kara, Divya Dhatri, and Mahalaxmi Rathnanand. "Cocrystals and Drug–Drug Cocrystals of Anticancer Drugs: A Perception towards Screening Techniques, Preparation, and Enhancement of Drug Properties." Crystals 12, no. 10 (2022): 1337. http://dx.doi.org/10.3390/cryst12101337.

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The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral absorption of anticancer drugs with low aqueous solubility and drug impermeability is currently an effective area of research. Many scientists have looked into pharmaceutical cocrystals as a way to improve the physicochemical properties of several anticancer drugs. Benefits of pharmaceutical cocrystals over other solid forms may include improv
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Ullah, Majeed, Hanif Ullah, Ghulam Murtaza, Qaisar Mahmood, and Izhar Hussain. "Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/870656.

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The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at varying drug to polymer ratios (1 : 1 to 1 : 0.25) in matrix tablets. The polymorphic phase disproportionation during in-depth dissolution studies of CBZ-SUC cocrystals and its crystalline properties were scrutinized by X-ray powder diffractrometry and Raman spectroscopy. The percent drug release from H
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Dhibar, Manami, Santanu Chakraborty, Souvik Basak, et al. "Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment." Pharmaceuticals 16, no. 2 (2023): 284. http://dx.doi.org/10.3390/ph16020284.

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In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan. The chemistry behind cocrystallization and the optimization of drug-coformer molar ratio were explored by the molecular docking approach, and theoretical were implemented practically to solve the solubility as well as bioavailability related issues of telmisartan. A new multicomponent solid form, i.e., cocrystal, was fabricated using different m
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Machado Cruz, Ricardo, Tereza Boleslavská, Josef Beránek, et al. "Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal." Pharmaceutics 12, no. 8 (2020): 741. http://dx.doi.org/10.3390/pharmaceutics12080741.

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The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field. In this work, the cocrystal approach was explored for a very poorly water soluble antifungal active, itraconazole (ITR), which was, for the first time, successfully converted into this multicomponent solid using an aromatic coformer, terephthalic acid (TER). The new cocrystal was characterized in terms of its solid-state and structural properties, and a panel of pharmaceutical tests including wettability and dissolution
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Machado, Cruz Ricardo, Tereza Boleslavská, Josef Beránek, et al. "Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal." Pharmaceutics 12 (August 6, 2020): 741. https://doi.org/10.3390/pharmaceutics12080741.

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Abstract: The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field. In this work, the cocrystal approach was explored for a very poorly water soluble antifungal active, itraconazole (ITR), which was, for the first time, successfully converted into this multicomponent solid using an aromatic coformer, terephthalic acid (TER). The new cocrystal was characterized in terms of its solid-state and structural properties, and a panel of pharmaceutical tests including wettability and d
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Dissertations / Theses on the topic "Drug-Drug Cocrystal"

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Mukherjee, Sreya. "Applications of Molecular Modelling and Structure Based Drug Design in Drug Discovery." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6331.

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Calcium ions have important roles in cellular processes including intracellular signaling, protein folding, enzyme activation and initiation of programmed cell death. Cells maintain low levels of calcium in their cytosol in order to regulate these processes. When activation of calcium-dependent processes is needed, cells can release calcium stored in the endoplasmic reticulum (ER) into the cytosol to initiate the processes. This can also initiate formation of plasma membrane channels that allow entry of additional calcium from the extracellular milieu. The change in calcium levels is referred
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Palanisamy, V., P. Sanphui, G. Bolla, Aditya Narayan, Colin C. Seaton, and Venu R. Vangala. "Intriguing High Z'' Cocrystals of Emtricitabine." Crystal Growth & Design, 2020. http://hdl.handle.net/10454/17968.

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Yes<br>Emtricitabine (ECB) afforded dimorphic cocrystals (Forms I, II) of benzoic acid (BA), whereas with p-hydroxybenzoic acid (PHBA), p-aminobenzoic acid (PABA) are resulted in as high Z'' cocrystals. Intriguingly, the Z'' of cocrystals are trends from two to fourteen based on the manipulation of functional groups on the para position of BA (where H atom is replaced with that of OH or NH2 group). ECB‒PABA cocrystal consists of six molecules each and two water molecules in the asymmetric unit (Z''=14) with 2D planar sheets represents the rare pharmaceutical cocrystal. The findings suggest tha
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Serrano, D. R., P. O'Connell, Krzysztof J. Paluch, D. Walsh, and A. M. Healy. "Cocrystal habit engineering to improve drug dissolution and alter derived powder properties." 2015. http://hdl.handle.net/10454/13683.

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Yes<br>Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim of this work was to engineer SDM:4-ASA cocrystals with different habits in order to investigate the effect on dissolution, and the derived powder properties of flow and compaction. Methods: Cocrystals were prepared in a 1:1 molar ratio by solvent evaporation using ethanol (habit I) or acetone (habit II), solvent evaporation followed by grinding (habit III) and spray-dr
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Khan, E., A. Shukla, Niten B. Jadav, et al. "Study of molecular structure, chemical reactivity and H-bonding interactions in the cocrystal of nitrofurantoin with urea." 2017. http://hdl.handle.net/10454/13220.

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Yes<br>The cocrystal of nitrofurantoin with urea (C8H6N4O5)·(CH4N2O), a non-ionic supramolecular complex, has been studied. Nitrofurantoin (NF) is a widely used antibacterial drug for the oral treatment of infections of the urinary tract. Characterization of the cocrystal of nitrofurantoin with urea (NF–urea) was performed spectroscopically by employing FT-IR, FT- and dispersive-Raman, and CP-MAS solid-state 13C NMR techniques, along with quantum chemical calculations. With the purpose of having a better understanding of H-bonding (inter- and intra-molecular), two different models (monomer and
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Chow, P. S., G. Lau, W. K. Ng, and Venu R. Vangala. "Stability of Pharmaceutical Cocrystal During Milling: A Case Study of 1:1 Caffeine-Glutaric Acid." 2017. http://hdl.handle.net/10454/12360.

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yes<br>Despite the rising interest in pharmaceutical cocrystals in the past decade, there is a lack of research in the solid processing of cocrystals downstream to crystallization. Mechanical stress induced by unit operations such as milling could affect the integrity of the material. The purpose of this study is to investigate the effect of milling on pharmaceutical cocrystal and compare the performance of ball mill and jet mill, using caffeine-glutaric acid (1:1) cocrystal as the model compound. Our results show that ball milling induced polymorphic transformation from the stable Form II
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Aher, Suyog, Ravindra S. Dhumal, K. R. Mahadik, J. Ketolainen, and Anant R. Paradkar. "Effect of cocrystallization techniques on compressional properties of caffeine/oxalic acid 2:1 cocrystal." 2013. http://hdl.handle.net/10454/10107.

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No<br>Caffeine/oxalic acid 2:1 cocrystal exhibited superior stability to humidity over caffeine, but compressional behavior is not studied yet. To compare compressional properties of caffeine/oxalic acid 2:1 cocrystal obtained by different cocrystallization techniques. Cocrystal was obtained by solvent precipitation and ultrasound assisted solution cocrystallization (USSC) and characterized by X-ray powder diffraction and scanning electron microscopy. Compaction study was carried out at different compaction forces. Compact crushing strength, thickness and elastic recovery were determined. Comp
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Kelly, Adrian L., Timothy D. Gough, Ravindra S. Dhumal, S. A. Halsey, and Anant R. Paradkar. "Monitoring ibuprofen-nicotinamide cocrystal formation during solvent free continuous cocrystallization (SFCC) using near infrared spectroscopy as a PAT tool." 2012. http://hdl.handle.net/10454/6044.

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No<br>The purpose of this work was to explore NIR spectroscopy as a PAT tool to monitor the formation of ibuprofen and nicotinamide cocrystals during extrusion based solvent free continuous cocrystallization (SFCC). Drug and co-former were gravimetrically fed into a heated co-rotating twin screw extruder to form cocrystals. Real-time process monitoring was performed using a high temperature NIR probe in the extruder die to assess cocrystal content and subsequently compared to off-line powder X-ray diffraction measurements. The effect of processing variables, such as temperature and mixing inte
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Shukla, A., E. Khan, M. H. D. Bashir Alsirawan, R. Mandal, P. Tandon, and Venu R. Vangala. "Spectroscopic (FT-IR, FT-Raman, and 13C SS-NMR) and quantum chemical investigations to provide structural insights into nitrofurantoin–4-hydroxybenzoic acid cocrystals." 2019. http://hdl.handle.net/10454/17019.

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Yes<br>Cocrystallization is an attractive approach to improving the physicochemical properties of active pharmaceutical ingredients (APIs), which have great potential in drug development. Accordingly, there is a growing need to understand the physicochemical changes that occur upon co-crystallisation. This work focuses on the combined use of spectroscopy and density functional theory (DFT) calculations to understand the molecular structure, hydrogen bond interactions and physicochemical properties of a pharmaceutical cocrystal. Solid-state NMR (ssNMR) spectroscopy can provide detailed molecula
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Books on the topic "Drug-Drug Cocrystal"

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Cocrystal Applications in Drug Delivery. MDPI, 2021. http://dx.doi.org/10.3390/books978-3-03943-984-3.

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Book chapters on the topic "Drug-Drug Cocrystal"

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Newman, Ann, Cen Chen, and Carlos Sanrame. "Salt and Cocrystal Screening." In Early Drug Development. Wiley-VCH Verlag GmbH & Co. KGaA, 2018. http://dx.doi.org/10.1002/9783527801756.ch10.

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Brittain, Harry G. "Cocrystal Systems of Pharmaceutical Interest: 2009." In Profiles of Drug Substances, Excipients and Related Methodology. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-387667-6.00010-5.

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Brittain, Harry G. "Cocrystal Systems of Pharmaceutical Interest: 2012–2014." In Profiles of Drug Substances, Excipients and Related Methodology. Elsevier, 2019. http://dx.doi.org/10.1016/bs.podrm.2018.11.004.

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Brittain, Harry G. "Cocrystal Systems of Pharmaceutical Interest: 2007–2008." In Profiles of Drug Substances, Excipients and Related Methodology. Elsevier, 2010. http://dx.doi.org/10.1016/s1871-5125(10)35009-6.

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Chavan, Rahul B., and Nalini R. Shastri. "Overview of Multicomponent Solid Forms." In Alternative Pain Management. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1680-5.ch004.

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Multi-drug therapy involves the simultaneous or sequential administration of two or more drugs with similar or different mechanisms of action and is efficient in combating various ailments such as cancer, diabetes, and rheumatoid arthritis. It has emerged advantageous due to larger therapeutic benefits, an increase in patient compliance, lower administrative costs, and reduced number of prescriptions. In the recent past, the clinical success of the Novartis product Entresto (sacubitril, disodium valsartan and water) and Esteve product E-58425 (tramadol and celecoxib) has boosted the developmen
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Sunitha, Ramineni, Praveen Sivadasu, and Raghavendra Kumar Gund. "Gabapentin Novel Co-Crystals: an Attempt to Enhance Physicochemical Parameters." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00400.

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Co-crystals are used to overcome the limitations of poor solubility and poor oral bioavailability of pharmaceuticals. The multiple components of co-crystals are interacting non-covalently with solvent where API properties are improved. The current research mainly focuses on formulating and evaluating Gabapentin (GBP) cocrystals with various coformers like L-Ascorbic acid and Acetyl salicylic acid. The current study of Novel co-crystals is prepared by using the co-grinding method in different stoichiometric ratios of 1:1 and 1:3. FTIR, PXRD, SEM, flow characteristics, inherent solubility, and i
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Conference papers on the topic "Drug-Drug Cocrystal"

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Zhang, Ziming, Yong Du, and Zhi Hong. "Terahertz Investigation of Drug-Drug Cocrystal Involving 4-aminosalicylic Acid and Pyrazinamide." In 2020 45th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2020. http://dx.doi.org/10.1109/irmmw-thz46771.2020.9370937.

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Wan, Mei, Ziming Zhang, Yong Du, and Zhi Hong. "Terahertz Investigation of Ternary Drug-bridge-drug Cocrystal Formed between Pyrazinamide, Fumaric Acid and Isoniazid." In 2021 46th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2021. http://dx.doi.org/10.1109/irmmw-thz50926.2021.9567331.

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Wan, Mei, Jiyuan Fang, Jiale Zhang, Zhi Hong, and Yong Du. "Terahertz Spectroscopy and Crystal Structure Analysis of Non-Steroidal Anti-Inflammatory Drug Ethenzamide Cocrystals." In 2022 47th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2022. http://dx.doi.org/10.1109/irmmw-thz50927.2022.9895745.

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