Academic literature on the topic 'Drug elution'

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Journal articles on the topic "Drug elution"

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Tzafriri, Abraham Rami, and Elazer Reuven Edelman. "Endovascular Drug Delivery and Drug Elution Systems." Interventional Cardiology Clinics 5, no. 3 (2016): 307–20. http://dx.doi.org/10.1016/j.iccl.2016.02.007.

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Glickman, Marc. "Drug eluting grafts for hemodialysis access." Journal of Vascular Access 18, no. 1_suppl (2017): S53—S55. http://dx.doi.org/10.5301/jva.5000671.

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The development of new methods for drug elution of graft material, biofiber films and resurfacing of prosthetic graft surfaces offers new opportunities for improvement of graft function in arteriovenous (AV) access. Three areas of research include developing grafts that reduce the development of neointimal hyperplasia, reducing infection and reducing thrombogenicity. The only drug eluting graft presently being used, is the heparin coated expanded polytetrafluoroethylene (ePTFE) graft, which has been shown to decrease the incidence of early thrombosis. New drug eluting grafts include those with
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Jiang, Zhihua, John Kamerud, Minlei Zhang, et al. "Strategies to develop highly drug-tolerant cell-based neutralizing antibody assay: neutralizing antidrug antibodies extraction and drug depletion." Bioanalysis 12, no. 18 (2020): 1279–93. http://dx.doi.org/10.4155/bio-2020-0091.

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Aim: Drug interference poses great analytical challenges for cell-based neutralizing antidrug antibodies (NAb) assay. The work aimed to improve assay drug tolerance through biotin-drug extraction with acid dissociation method optimization and developing new approach. Results: The NAb extraction with biotin-drug extraction with acid dissociation approach has been optimized by reducing biotinylated drug leaching and improving NAb elution efficiency, resulting in drug tolerance of up to 160 μg/ml. To circumvent the low acid elution efficiency of NAb from drug, a novel drug depletion approach was
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Peretsmanas, E. O., A. A. Аrtyukhov, M. I. Shtilman, I. V. Esin, V. S. Zubikov, and I. A. Gerasimov. "Study of elution characteristics of anti-tuberculosis drugs mixed with bone cement." Tuberculosis and Lung Diseases 99, no. 4 (2021): 30–35. http://dx.doi.org/10.21292/2075-1230-2021-99-4-30-35.

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The objective: to assess the elution characteristics of anti-tuberculosis drugs (isoniazid, cycloserine, rifampicin, amikacin, kanamycin, ethambutol) placed into bone cement samples and put in a liquid medium to determine the possibility of using such systems as a drug reservoir.Subjects and methods. For in vitro studies, pure substances of the drugs were used. The spectrophotometry was used to study the elution kinetics of the drugs. Absorption spectra of the drugs in the visible and ultraviolet regions were analyzed to reveal the absorption maxima, and the resistance of the chemical structur
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Shand, James A., Vivek Kodoth, and Ian BA Menown. "Novel stent and drug elution technologies." Interventional Cardiology 3, no. 4 (2011): 473–81. http://dx.doi.org/10.2217/ica.11.48.

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Zivelonghi, Carlo, Giulia Geremia, Michele Pighi, and Flavio Ribichini. "The Role of Stent Design and Polymers in Safety Outcomes – A Review." European Cardiology Review 8, no. 1 (2012): 63. http://dx.doi.org/10.15420/ecr.2012.8.1.63.

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Each component of a drug-eluting stent (DES) contributes to the safety of the device. Continuous efforts are being dedicated to the search of the optimal compromise between facility of use, safety and long-term efficacy. Shorter balloons reduce the vascular trauma beyond the stent struts; the metallic composition of the stent platform and the platform itself interact with the vascular wall in a long-lasting equilibrium between radial force, vessel patency and reparative cellular regrowth. The modality of drug elution is largely regulated by the chosen drug carrier, rather than by the chemical
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Tanaka, Takuro, Koichiro Ikeda, Shuichi Yamamoto, and Noriko Yoshimoto. "Elution Profiles of Antibody-Drug Conjugates in Preparative Chromatography." MATEC Web of Conferences 333 (2021): 14001. http://dx.doi.org/10.1051/matecconf/202133314001.

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Monoclonal antibody drug conjugate (ADCs) have received much attention as pharmaceutical agents for treating serious diseases such as cancer. However, it is difficult to separate them on the basis of the drug to antibody ratio, DAR. Hydrophobic chromatography (HIC) is commonly used for the analysis of the drug to antibody ratio, DAR. The retention of ADCs on HIC can be controlled by the hydrophobic nature of ADCs, depending on the mobile phase conditions. They are sometimes performed at the restricted conditions where the solubility is too low. Ion exchange chromatography (IEC) using electrost
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Tanaka, Takuro, Koichiro Ikeda, Shuichi Yamamoto, and Noriko Yoshimoto. "Elution Profiles of Antibody-Drug Conjugates in Preparative Chromatography." MATEC Web of Conferences 333 (2021): 14001. http://dx.doi.org/10.1051/matecconf/202133314001.

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Monoclonal antibody drug conjugate (ADCs) have received much attention as pharmaceutical agents for treating serious diseases such as cancer. However, it is difficult to separate them on the basis of the drug to antibody ratio, DAR. Hydrophobic chromatography (HIC) is commonly used for the analysis of the drug to antibody ratio, DAR. The retention of ADCs on HIC can be controlled by the hydrophobic nature of ADCs, depending on the mobile phase conditions. They are sometimes performed at the restricted conditions where the solubility is too low. Ion exchange chromatography (IEC) using electrost
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Kalachev, L. V. "Modelling Simple Experimental Platform for In Vitro Study of Drug Elution from Drug Eluting Stents (DES)." Journal of Physics: Conference Series 727 (June 2016): 012005. http://dx.doi.org/10.1088/1742-6596/727/1/012005.

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Hagan, Alice, Marcus Caine, Cara Press, et al. "Predicting pharmacokinetic behaviour of drug release from drug-eluting embolization beads using in vitro elution methods." European Journal of Pharmaceutical Sciences 136 (August 2019): 104943. http://dx.doi.org/10.1016/j.ejps.2019.05.021.

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Dissertations / Theses on the topic "Drug elution"

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Baker, Steven Gerald. "In vitro elution of analgesic medications from an absorbable gelatin sponge." Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/8790.

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Master of Science<br>Department of Clinical Sciences<br>Walter C. Renberg<br>Objective: To compare the in vitro elution characteristics of six common analgesic medications from a commercially available absorbable gelatin sponge. Study Design: Experimental study. Methods: Gelatin sponges were loaded with various analgesic medications, including two opioids, preservative-free morphine and fentanyl, two local anesthestics, bupivacaine and lidocaine, and two α2-adrenergic agonists, dexmedetomidine and xylazine. The loaded sponges were placed in dishes containing phosphate-buffered saline (P
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Zhao, Yibei. "Phospholipid Transport in Silicon Hydrogel Contact Lenses." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/3083.

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Dry eye syndrome has been associated with the lack of phospholipids in the tear film, leading to disruption of the tear film and subsequent irritation. Characterization of the transport and release of phospholipids from a silicone hydrogel contact lens is required to assess the possible use of these lenses for phospholipid delivery to increase patient comfort. This thesis examines the use of silicone hydrogel contact lenses as phospholipid delivery devices. Contact lenses of silicone hydrogel composition were loaded with varying amounts of radiolabeled 1,2-dimyristoyl-sn-glycero-3-phosphocholi
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Safranski, David Lee. "Poly(beta-amino esters) for cardiovascular applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42825.

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Abdominal aortic aneurysms are a leading cause of death in the U.S. where 14,000 people die from aneurysm rupture and 178,000 are diagnosed each year. A novel alternative treatment for abdominal aortic aneurysms has been proposed, where a biodegradable polymer scaffold is photopolymerized in situ around the exterior of the aneurysm. This scaffold will mechanically constrain the aneurysm from further expansion, and will deliver a drug, doxycycline, to treat the underlying biological cause of the disease. In order for device development, a suitable polymer must be designed with appropriate mecha
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Bozsak, Franz. "Optimization of Drug-Eluting Stents." Palaiseau, Ecole polytechnique, 2013. https://pastel.hal.science/pastel-00858100.

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L'utilisation de stents actifs (DES) a révolutionné le traitement de l'athérosclérose. Le relargage contrôlé de médicaments anti-prolifératifs dans la paroi artérielle (PA) a permis de réduire fortement le taux de resténose intra-stent. Mais le risque de thromboses intra-stents tardives demeure un enjeu majeur des DES en partie lié au retard de cicatrisation de la PA endommagée lors de l'implantation. Cette thèse présente une méthode d'optimisation du design des DES afin d'inhiber la resténose sans affecter la cicatrisation. Pour quantifier la performance des différents designs, un modèle numé
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Suhardi, Vincentius Jeremy. "Drug eluting prosthetic joints through drug cluster morphology control." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111323.

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Thesis: Ph. D. in Medical Engineering and Medical Physics, Harvard-MIT Program in Health Sciences and Technology, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 299-330).<br>More than one million joint replacements are performed in the USA annually. However, around 10 % of patients require revision surgery within 10 years with prosthetic joint infections (PJI) as a common reason. PJI has a recurrence rate of 16 %, a mortality rate of 2.5 %, and end-stage treatments involving arthrodesis and amputation. Most drug eluting polymers that were in develo
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Ahrenstedt, Lage. "Drug Eluting Hydrogels : Design, Synthesis and Evaluation." Doctoral thesis, University of Cape Town, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-36503.

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Hydrogels have successfully proved themselves useful for drug delivery applications and several delivery routes have been developed over the years. The particular interest in this work was to design, synthesise and evaluate in situ forming drug eluting hydrogels, which have the potential to ameliorate the healing of cardiovascular diseases. With this aim the anti-inflammatory and immunosuppressant drugs rapamycin (Ra) and dexamethasone (Dex) were made water soluble by conjugation with polyethylene glycol (PEG). Ra was attached pendant from the terminal of PEGs while Dex was incorporated into d
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Van, den Bergh Willem Johannes Wian. "Drug eluting electrospun scaffolds for tissue regeneration." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29581.

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The desired healing response to electrospun scaffolds in tissue engineering is often limited by poor ingrowth due to insufficient porosity, thrombogenicity, lack of vascularisation and/or excessive inflammation. This study aimed at increasing structural porosity and incorporating/delivering anti-thrombotic/angiogenic (heparin) and anti-inflammatory (dexamethasone) agents. Porosity enhancement techniques were explored using two different approaches i) electrospinning of biostable polymer (Pellethane® , Pel) with concomitant electrospraying of soluble microparticles, which were subsequently remo
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Dolla, William Jacob Spenner Becker Bryan R. "Drug diffusion and structural design criteria for conventional and auxetic drug-eluting stents." Diss., UMK access, 2006.

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Thesis (Ph. D.)--School of Computing and Engineering and Dept. of Chemistry. University of Missouri--Kansas City, 2006.<br>"A dissertation in engineering and chemistry." Advisor: Bryan R. Becker. Typescript. Vita. Description based on contents viewed Jan. 26, 2007; title from "catalog record" of the print edition. Includes bibliographical references (leaves 127-130). Online version of the print edition.
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Ashrafi, Koorosh. "Novel bioresponsive drug eluting microspheres to enhance chemoembolisation therapy." Thesis, University of Brighton, 2014. https://research.brighton.ac.uk/en/studentTheses/d72e0cce-8b99-4659-9b8d-c0e5a48da701.

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Drug eluting beads (DEB) are employed in the treatment of solid hypervascularised malignant tumours by a method called trans-arterial chemoembolisation (TACE). When the microcirculation to a tumour is blocked, oxygen levels decrease to critically low levels causing the tumour to become hypoxic. Hypoxic tumours are known to be chemoresistant and send out growth factor signals leading to angiogenesis and metastasis of tumour cells to other parts of the body. Commercially available DEB are unable to respond to the conditions of hypoxia and will continue to release drug at a constant rate via ioni
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Frahnow, Andreas [Verfasser]. "Lebensqualitätsentwicklung nach Implantation von drug eluting stents im Vergleich zu bare metal stents : eine Analyse des Deutschen Drug Eluting Stent-Registers (DES.DE) / Andreas Frahnow." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042147/34.

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Books on the topic "Drug elution"

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Krul, Kenneth G. Drug-eluting stents: Markets and technologies. Edited by Heffner Steven and Kalorama Information LLC. Kalorama Information, 2003.

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J, White Christopher, ed. Drug-eluting stents. Taylor & Francis, 2005.

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W, Serruys P., and Gershlick A. H, eds. Handbook of drug-eluting stents. Taylor & Francis, 2005.

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Serruys, Patrick W., and Anthony H. Gershlick. Handbook of Drug-Eluting Stents. Informa Healthcare, 2005.

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Serruys, Patrick W., and Anthony H. Gershlick. Handbook of Drug-Eluting Stents. CRC Press, 2005. http://dx.doi.org/10.1201/9780367800628.

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(Editor), Alexandre Abizaid, Martin B. Leon (Editor), and Alexandra Lansky (Editor), eds. Textbook of Drug Eluting Stents. Taylor & Francis Ltd, 2006.

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1967-, Mittmann Nicole, and Canadian Coordinating Office for Health Technology Assessment., eds. Drug eluting stents: An economic evaluation. Canadian Coordinating Office for Health Technology Assessment, 2005.

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1967-, Mittmann Nicole, and Canadian Coordinating Office for Health Technology Assessment., eds. Economic evaluation of drug eluting stents. Canadian Coordinating Office for Health Technology Assessment, 2005.

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Antonio, Colombo, and Stankovic Goran MD, eds. Colombo's tips & tricks for drug-eluting stents. Taylor & Francis, 2005.

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Colombo, Antonio, and Goran Stankovic. Colombo's Tips & Tricks for Drug Eluting Stents. Informa Healthcare, 2005.

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Book chapters on the topic "Drug elution"

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Das, S. Sarkar, M. K. McDermott, A. D. Lucas, et al. "Absorbable Coatings: Structure and Drug Elution." In IFMBE Proceedings. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14998-6_61.

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Vo, Tuoi T. N., Amy M. M. Collins, and William T. Lee. "Mathematical Modelling of Drug Elution from Drug-Filled Stents." In Progress in Industrial Mathematics at ECMI 2016. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63082-3_11.

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Kohn, Kurt W. "DNA filter elution methods in anticancer drug development." In Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2061-6_1.

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Khan, Wahid, Rajesh Thipparaboina, Shady Farah, Judah Z. Weinberger, and Abraham J. Domb. "Drug-Eluting Stents." In Advances in Delivery Science and Technology. Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-9434-8_18.

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Chauhan, Anoop, and Ranjit S. More. "Drug-eluting Stents." In Atlas of Interventional Cardiology. Current Medicine Group, 2003. http://dx.doi.org/10.1007/978-1-4613-1091-4_11.

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Zhao, Jonathon, and Lori Alquier. "Drug-Eluting Stents." In Long Acting Injections and Implants. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0554-2_19.

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Schiesser, W. E. "Drug Eluting Stents." In Time Delay ODE/PDE Models. CRC Press, 2019. http://dx.doi.org/10.1201/9780367427986-8.

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Zilberman, Meital, Amir Kraitzer, Orly Grinberg, and Jonathan J. Elsner. "Drug-Eluting Medical Implants." In Drug Delivery. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00477-3_11.

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Han, Jingjia, and Peter I. Lelkes. "Drug-Eluting Vascular Grafts." In Advances in Delivery Science and Technology. Springer US, 2013. http://dx.doi.org/10.1007/978-1-4614-9434-8_19.

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Moyer, Carey D., Peter B. Berger, and Christopher J. White. "Drug-Eluting Coronary Stents." In Cardiovascular Medicine. Springer London, 2007. http://dx.doi.org/10.1007/978-1-84628-715-2_48.

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Conference papers on the topic "Drug elution"

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Ho, Dean. "Functionalized nanodiamond platforms for applications in systemic and localized drug elution." In 2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems. IEEE, 2009. http://dx.doi.org/10.1109/nems.2009.5068789.

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Boyle, Colin J., Caitríona Lally, and Patrick J. Prendergast. "Injury Driven Biological Model of Restenotic Lesion Development Predicts the Effects of Stent Geometry on Restenosis." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206342.

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One of the most significant limitations of percutaneous coronary intervention using stents is the growth of tissue within the stent, leading to re-occlusion of the target vessel. There is a wide range of stents available, and stent designs differ in their efficacy [1]. Stent parameters such as stent length, strut configuration, diameter and expansion method have been shown to influence the amount of restenosis provoked [2]. Despite many generations of coronary stents — and the advent of drug elution — up to 10% of percutaneous coronary interventions require revision, climbing to 50% in some hi
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Zarandi, Marjan Molavi, Rosaire Mongrain, and Olivier F. Bertrand. "Modeling Drug Eluting Stents for Coronary Artery Bifurcation Considering Non-Newtonian Effects." In ASME 2010 3rd Joint US-European Fluids Engineering Summer Meeting collocated with 8th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-31190.

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Drug Eluting Stents (DES) are commonly used for the treatment of stenotic arteries. Restenosis can be treated by delivering anti-thrombotic and anti-proliferative drugs to the arterial wall. The main mechanism of the drug eluting stent is to allow diffusion of the drug from the coating on the stent, into the arterial wall over a prolonged period of time. Investigation of blood flow hemodynamics and shear stress are of great importance in understanding the transport of drugs through the circulatory systems and predicting the performance of drug eluting stents. While drug eluting stent effective
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Callanan, Anthony, Michael Walsh, and Tim McGloughlin. "The Effects on the Strength of UBM Extracellular Matrix Under Stent Loading: An Experimental and Numerical Study." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206892.

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Arterial diseases are a common cause of death in the western world. The last two decades has seen vast improvements in scanning, screening, prognosis and symptom recognition, resulting in a greater number of treatments. A common treatment procedure used is bypass grafting which currently utilize synthetic graft materials, internal thoracic artery, and autologous vein. These treatments are invasive surgical procedures and can have low patency. An alternative treatment for these conditions is endovascular surgery. However these devices have problems such as restenois, migration and stent fractur
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Bozsak, Franz, Jean-Marc Chomaz, Fulvio Martinelli, and Abdul I. Barakat. "Modeling Arterial Wall Transport for Drug-Eluting Stents." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53871.

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Drug-eluting stents (DES) are very commonly used for treating coronary atherosclerotic lesions. Despite the broad effectiveness of DES, ∼5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. The occurrence of these complications depends on various factors including the concentration of the eluted drug in the arterial wall and the rate of arterial re-endothelialization. Drug concentration in the arterial wall needs to be sufficiently high to be efficacious while remaining sufficiently low to avoid compromising wall stability (leading to stent m
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Dolla, William Jacob S., Brian A. Fricke, and Bryan R. Becker. "Auxetic Drug-Eluting Stent Design." In ASME 2006 Frontiers in Biomedical Devices Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/nanobio2006-18035.

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A cardiovascular stent is a cylindrical wire mesh structure that is permanently introduced into an artery during angioplasty (balloon dilatation) to act as a scaffold, thus preventing elastic recoil and/or sudden collapse of the damaged artery. While cardiovascular stents virtually eliminate elastic recoil and/or collapse of the artery, recognition of the stent as a foreign material triggers a human immune system response causing re-closure, or restenosis, of the artery. A recent advancement to counteract restenosis is to employ drug-eluting stents to locally deliver immunosuppressant and anti
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Welch, Tre R., Robert C. Eberhart, and Cheng-Jen Chuong. "Thermal Treatment Effects Upon the Degradation Characteristics of PLLA Coiled Stents." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206884.

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Stents are a medical device used to restore blood flow in stenosed vessels. During the process of stent expansion, the balloon and stent could damage the endothelial lining of the vascular wall and alter the mechanical stress states of various tissue components. The evolution of stents has progressed from bare metal stents to drug eluting stents or stents coated with drugs such as Sirolimus. Drug eluting stents are currently used to address the restenosis event that occurs after implantation. These stents have been effective but late stent thrombosis has been an emerging issue with drug elutin
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Parsonage, E., T. Girton, and D. Knapp. "Biomaterial considerations for drug-eluting stents." In 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2009. http://dx.doi.org/10.1109/iembs.2009.5335396.

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Wang, Yen-Ting, Yi-Ping Wang, Tzu-Yuan Lin, Chien-Erh Lin, and Hao-Ming Hsiao. "Drug-eluting stent with rhombic-shape reservoirs for drug delivery." In 2016 International Conference on Applied System Innovation (ICASI). IEEE, 2016. http://dx.doi.org/10.1109/icasi.2016.7539756.

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Lee, Dong-Ki, and Sung Ill Jang. "Drug-eluting stent in malignant biliary obstruction." In SPIE Nanosystems in Engineering + Medicine, edited by Sang H. Choi, Jin-Ho Choy, Uhn Lee, and Vijay K. Varadan. SPIE, 2012. http://dx.doi.org/10.1117/12.2000469.

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Reports on the topic "Drug elution"

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Peter W. Carr, K.M. Fuller, D.R. Stoll, L.D. Steinkraus, M.S. Pasha, and Glenn G. Hardin. Fast Gradient Elution Reversed-Phase HPLC with Diode-Array Detection as a High Throughput Screening Method for Drugs of Abuse. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/892807.

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Short-term dual antiplatelet treatment may be best for most patients after receiving a drug-eluting stent. National Institute for Health Research, 2019. http://dx.doi.org/10.3310/signal-000828.

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