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Journal articles on the topic 'Drug elution'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Tzafriri, Abraham Rami, and Elazer Reuven Edelman. "Endovascular Drug Delivery and Drug Elution Systems." Interventional Cardiology Clinics 5, no. 3 (2016): 307–20. http://dx.doi.org/10.1016/j.iccl.2016.02.007.

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2

Glickman, Marc. "Drug eluting grafts for hemodialysis access." Journal of Vascular Access 18, no. 1_suppl (2017): S53—S55. http://dx.doi.org/10.5301/jva.5000671.

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The development of new methods for drug elution of graft material, biofiber films and resurfacing of prosthetic graft surfaces offers new opportunities for improvement of graft function in arteriovenous (AV) access. Three areas of research include developing grafts that reduce the development of neointimal hyperplasia, reducing infection and reducing thrombogenicity. The only drug eluting graft presently being used, is the heparin coated expanded polytetrafluoroethylene (ePTFE) graft, which has been shown to decrease the incidence of early thrombosis. New drug eluting grafts include those with

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3

Jiang, Zhihua, John Kamerud, Minlei Zhang, et al. "Strategies to develop highly drug-tolerant cell-based neutralizing antibody assay: neutralizing antidrug antibodies extraction and drug depletion." Bioanalysis 12, no. 18 (2020): 1279–93. http://dx.doi.org/10.4155/bio-2020-0091.

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Aim: Drug interference poses great analytical challenges for cell-based neutralizing antidrug antibodies (NAb) assay. The work aimed to improve assay drug tolerance through biotin-drug extraction with acid dissociation method optimization and developing new approach. Results: The NAb extraction with biotin-drug extraction with acid dissociation approach has been optimized by reducing biotinylated drug leaching and improving NAb elution efficiency, resulting in drug tolerance of up to 160 μg/ml. To circumvent the low acid elution efficiency of NAb from drug, a novel drug depletion approach was

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4

Peretsmanas, E. O., A. A. Аrtyukhov, M. I. Shtilman, I. V. Esin, V. S. Zubikov, and I. A. Gerasimov. "Study of elution characteristics of anti-tuberculosis drugs mixed with bone cement." Tuberculosis and Lung Diseases 99, no. 4 (2021): 30–35. http://dx.doi.org/10.21292/2075-1230-2021-99-4-30-35.

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The objective: to assess the elution characteristics of anti-tuberculosis drugs (isoniazid, cycloserine, rifampicin, amikacin, kanamycin, ethambutol) placed into bone cement samples and put in a liquid medium to determine the possibility of using such systems as a drug reservoir.Subjects and methods. For in vitro studies, pure substances of the drugs were used. The spectrophotometry was used to study the elution kinetics of the drugs. Absorption spectra of the drugs in the visible and ultraviolet regions were analyzed to reveal the absorption maxima, and the resistance of the chemical structur

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5

Shand, James A., Vivek Kodoth, and Ian BA Menown. "Novel stent and drug elution technologies." Interventional Cardiology 3, no. 4 (2011): 473–81. http://dx.doi.org/10.2217/ica.11.48.

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6

Zivelonghi, Carlo, Giulia Geremia, Michele Pighi, and Flavio Ribichini. "The Role of Stent Design and Polymers in Safety Outcomes – A Review." European Cardiology Review 8, no. 1 (2012): 63. http://dx.doi.org/10.15420/ecr.2012.8.1.63.

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Each component of a drug-eluting stent (DES) contributes to the safety of the device. Continuous efforts are being dedicated to the search of the optimal compromise between facility of use, safety and long-term efficacy. Shorter balloons reduce the vascular trauma beyond the stent struts; the metallic composition of the stent platform and the platform itself interact with the vascular wall in a long-lasting equilibrium between radial force, vessel patency and reparative cellular regrowth. The modality of drug elution is largely regulated by the chosen drug carrier, rather than by the chemical

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7

Tanaka, Takuro, Koichiro Ikeda, Shuichi Yamamoto, and Noriko Yoshimoto. "Elution Profiles of Antibody-Drug Conjugates in Preparative Chromatography." MATEC Web of Conferences 333 (2021): 14001. http://dx.doi.org/10.1051/matecconf/202133314001.

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Monoclonal antibody drug conjugate (ADCs) have received much attention as pharmaceutical agents for treating serious diseases such as cancer. However, it is difficult to separate them on the basis of the drug to antibody ratio, DAR. Hydrophobic chromatography (HIC) is commonly used for the analysis of the drug to antibody ratio, DAR. The retention of ADCs on HIC can be controlled by the hydrophobic nature of ADCs, depending on the mobile phase conditions. They are sometimes performed at the restricted conditions where the solubility is too low. Ion exchange chromatography (IEC) using electrost

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8

Tanaka, Takuro, Koichiro Ikeda, Shuichi Yamamoto, and Noriko Yoshimoto. "Elution Profiles of Antibody-Drug Conjugates in Preparative Chromatography." MATEC Web of Conferences 333 (2021): 14001. http://dx.doi.org/10.1051/matecconf/202133314001.

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Monoclonal antibody drug conjugate (ADCs) have received much attention as pharmaceutical agents for treating serious diseases such as cancer. However, it is difficult to separate them on the basis of the drug to antibody ratio, DAR. Hydrophobic chromatography (HIC) is commonly used for the analysis of the drug to antibody ratio, DAR. The retention of ADCs on HIC can be controlled by the hydrophobic nature of ADCs, depending on the mobile phase conditions. They are sometimes performed at the restricted conditions where the solubility is too low. Ion exchange chromatography (IEC) using electrost

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9

Kalachev, L. V. "Modelling Simple Experimental Platform for In Vitro Study of Drug Elution from Drug Eluting Stents (DES)." Journal of Physics: Conference Series 727 (June 2016): 012005. http://dx.doi.org/10.1088/1742-6596/727/1/012005.

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10

Hagan, Alice, Marcus Caine, Cara Press, et al. "Predicting pharmacokinetic behaviour of drug release from drug-eluting embolization beads using in vitro elution methods." European Journal of Pharmaceutical Sciences 136 (August 2019): 104943. http://dx.doi.org/10.1016/j.ejps.2019.05.021.

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11

Enmark, Martin, Joakim Bagge, Jörgen Samuelsson, et al. "Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents." Analytical and Bioanalytical Chemistry 412, no. 2 (2019): 299–309. http://dx.doi.org/10.1007/s00216-019-02236-9.

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AbstractOligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fundamental understanding of the important preparative separation step, mass-overloaded injections of a fully phosphorothioated 16mer, i.e., deoxythymidine oligonucleotide, were performed on a C18 and a phenyl column. The narrowest elution profiles were obtained using the phenyl column, and the

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12

Merciadez, M., L. Alquier, R. Mehta, A. Patel, and A. Wang. "A Novel Method for the Elution of Sirolimus (Rapamycin) in Drug-Eluting Stents." Dissolution Technologies 18, no. 4 (2011): 37–42. http://dx.doi.org/10.14227/dt180411p37.

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13

Kawai, Tomoko, Hisashi Umeda, Masaya Ota, et al. "Do drug elution components increase the risk of fracture of sirolimus-eluting stents?" Coronary Artery Disease 21, no. 5 (2010): 298–303. http://dx.doi.org/10.1097/mca.0b013e32833aa6a1.

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14

Morino, Yoshihiro. "Modifying the Drug Elution Profile for Neointimal Control." Circulation Journal 74, no. 10 (2010): 2054–55. http://dx.doi.org/10.1253/circj.cj-10-0796.

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15

Micari, Antonio, and Roberto Nerla. "Needle-Delivered Drug Elution in Femoral Artery Disease." JACC: Cardiovascular Interventions 11, no. 10 (2018): 932–33. http://dx.doi.org/10.1016/j.jcin.2018.01.236.

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16

Jones, Alexander, Abhyuday Mandal, and Suraj Sharma. "Antibacterial and Drug Elution Performance of Thermoplastic Blends." Journal of Polymers and the Environment 26, no. 1 (2017): 132–44. http://dx.doi.org/10.1007/s10924-016-0924-y.

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17

Chen, I.-Cheng, Chen-Ying Su, Wei-Han Nien, et al. "Influence of Antibiotic-Loaded Acrylic Bone Cement Composition on Drug Release Behavior and Mechanism." Polymers 13, no. 14 (2021): 2240. http://dx.doi.org/10.3390/polym13142240.

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Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement with considerable morbidity and large economic burdens. Antibiotic-Loaded Bone Cement (ALBC) has been developed as a valuable tool for local administration and is becoming one of the most effective methods for the prevention and treatment of orthopedic infections. Controlling antibiotic release from ALBC is critical to achieve effective infection control, however, the antibiotic elution rates are generally low, and the mechanisms are poorly understood. Thus, the present study aims to investigate th

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18

Gonzalez, M. Victoria, Yiqing Tang, Gary J. Phillips, et al. "Doxorubicin eluting beads—2: methods for evaluating drug elution and in-vitro:in-vivo correlation." Journal of Materials Science: Materials in Medicine 19, no. 2 (2007): 767–75. http://dx.doi.org/10.1007/s10856-006-0040-y.

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19

Lin, Yi-Chia, Kuo-Sheng Liu, Demei Lee, Min-Jhan Li, Shih-Jung Liu, and Hiroshi Ito. "In Vivo and In Vitro Elution of Analgesics from Multilayered Poly(D,L)-lactide-co-glycolide Nanofibers Incorporated Ureteral Stents." Journal of Nanomaterials 2018 (March 7, 2018): 1–7. http://dx.doi.org/10.1155/2018/4943210.

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We develop novel analgesic-eluting nanofiber-incorporated ureteral stents that offer sustained release of lidocaine and ketorolac for local drug delivery. Lidocaine and poly(D,L)-lactide-co-glycolide (PLGA) were dissolved in hexafluoroisopropanol and were electrospun into nonwoven nanofibers onto the surface of ureteral stents. This was followed by electrospinning of another layer of PLGA nanofibers containing ketorolac. Electrospun drug-loaded nanofibers were then characterized using scanning electron microscopy, Fourier transform infrared spectroscopy, and water contact angle analysis. In ad

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20

Kuhn, Frederick A., Christopher T. Melroy, Howard L. Levine, and Andrew J. Diamond. "Drug-Eluting Spacer for Chronic Ethmoid Sinusitis Treatment." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P75. http://dx.doi.org/10.1016/j.otohns.2008.05.241.

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Objective The objective of this study is to assess the safety and efficacy of managing chronic ethmoid sinusitis with an implantable drug-eluting spacer filled with triamcinolone acetate. Methods 13 patients with chronic ethmoid sinusitis had drug-eluting spacers inserted on 22 sides under fluoroscopic guidance. The spacers were filled with triamcinolone acetate and their position was checked fluoroscopically. The spacers remained in place for 2–4 weeks. The measured post-treatment outcomes were SNOT-20 and Lund-MacKay CT scores. Serum triamcinolone levels were measured and complications were

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21

SWANSON, Neil, Qamar JAVED, Kai HOGREFE, and Anthony GERSHLICK. "Human internal mammary artery organ culture model of coronary stenting: a novel investigation of smooth muscle cell response to drug-eluting stents." Clinical Science 103, no. 4 (2002): 347–53. http://dx.doi.org/10.1042/cs1030347.

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Local drug delivery by coronary stents is of current research interest. Organ culture of human vascular tissue is a model of intimal hyperplasia. We report an ex vivo organ culture model of stented vessels. This allows stent–artery interactions to be studied in living tissue. The recognized anti-restenosis agent paclitaxel was chosen to test the organ culture model. Mammary artery specimens were cultured ‘closed’ (i.e. without opening them flat) for 72h. Phosphocholine-coated stents, half of them loaded with the anti-restenosis drug paclitaxel, were implanted. The absorption and elution charac

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22

Vardhani Devi, Duggirala Parvatha Venkata, Kapavarapu Maruthi Venkata Narayanarao, Pulipaka Shyamala, Rallabhandi Murali Krishna, and Komali Siva Prasad. "HPLC Estimation of New Impurity Methyl Ezetimibe in Ezetimibe Drug." Asian Journal of Chemistry 32, no. 6 (2020): 1309–13. http://dx.doi.org/10.14233/ajchem.2020.22533.

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A new gradient elution mode HPLC method was developed and validated to detect and monitor the novel impurity namely methyl ezitimibe in ezetimibe drug substances. Chromatographic detection and analysis of methyl ezetimibe was performed on XBridge C18 column with mobile phase consisting of 0.02 M phosphate buffer (pH 5) and acetonitrile with 1 mL/min flow rate in gradient elution mode. Methyl ezetimibe was detected and monitored at 248 nm. The calibration curve was linear over range of 0.015 to 0.219% concentration. The limit of detection and quantification were computed as 0.005% (signal to no

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23

Lafont, Antoine, and Eric Durand. "A.R.T.: concept of a bioresorbable stent without drug elution." EuroIntervention 5, F (2009): F83—F87. http://dx.doi.org/10.4244/eijv5ifa14.

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24

Migliavacca, F., F. Gervaso, M. Prosi, et al. "Expansion and drug elution model of a coronary stent." Computer Methods in Biomechanics and Biomedical Engineering 10, no. 1 (2007): 63–73. http://dx.doi.org/10.1080/10255840601071087.

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25

Melroy, Christopher T., and Frederick A. Kuhn. "Safety of Ethmoid Sinus Drug-Eluting Catheter Insertion." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P108. http://dx.doi.org/10.1016/j.otohns.2008.05.544.

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Problem The objective is to develop an instrument which allows a drug-eluting catheter to be safely and reproducibly inserted into the ethmoid sinuses. Methods A trochar-based insertion device was designed to allow delivery of a drug-eluting catheter into the anterior and posterior ethmoid sinuses. It was inserted into 12 cadaveric ethmoid sinuses under endoscopic and fluoroscopic guidance. CT scans were performed pre-, intra-, and post-procedure. The device's position was analyzed and the proximity to the skull base, lamina papyracea, and ethmoid face was measured. The specimens were then dis

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26

Shayganpour, Amirreza, Marco Salerno, Barbara Salis, and Silvia Dante. "Towards a single bioactive substrate combining SERS-effect and drug release control based on thin anodic porous alumina coated with gold and with lipid bilayers." MRS Advances 2, no. 30 (2017): 1597–604. http://dx.doi.org/10.1557/adv.2016.676.

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ABSTRACTThin anodic porous alumina (tAPA), engineered by electrochemical anodization of aluminum and post-fabrication etching, has already shown surface-enhanced Raman scattering (SERS) activity, after overcoating with a thin gold film. On the other hand, the tAPA nanoporous surface, which is biocompatible and presents controlled roughness, has been extensively investigated as a substrate for living cell cultures. Here, we are interested in exploiting the nanoporosity of tAPA as a drug reservoir and demonstrating drug-delivery capabilities of these substrates which can be combined with the abo

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27

Moon, Kyung-Suk, Ji-Myung Bae, Sungho Jin, and Seunghan Oh. "Infrared-Mediated Drug Elution Activity of Gold Nanorod-Grafted TiO2Nanotubes." Journal of Nanomaterials 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/750813.

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The purpose of this research was to prepare gold nanorod- (GNR-) grafted TiO2nanotubes by thiolactic acid treatment and evaluate remote-controlled drug elution and antibacterial activity by infrared (IR) light irradiation. Tetracycline used as an antibiotic was loaded into GNR-grafted TiO2nanotubes by using 2 w/v% polylactic acid solutions. A near-IR laser (830 nm) was used for remote-controlled IR light irradiation. Results of SEM, TEM, XRD, and EDX revealed that GNR chemically bonded to the whole surface of the TiO2nanotubes. An antibiotic release test revealed that on-off drug elution was t

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28

Hakkimane, Sushruta S., and Bharath Raja Guru. "NANO FORMULATION ANALYSIS: ANALYTICAL METHOD DEVELOPMENT OF ISONIAZID AND SIMULTANEOUS ESTIMATION OF ANTI-TUBERCULAR DRUGS ISONIAZID AND RIFAMPICIN BY RP-HPLC." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (2017): 330. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.17582.

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Objective: The objective of the study was to develop and validate a simple and reproducible reverse phase high pressure liquid chromatography (RPHPLC) method for hydrophilic drug isoniazid (INH) to apply for the analysis of the INH in nanoparticle drug formulations. Furthermore, to estimate simultaneously rifampicin (RIF) and INH in combined form.Methods: Isocratic elution with 10 minutes runtime on a C-18 Luna, 5 μ, 100Å, 150 mm column, methanol, and water as mobile phase with detection wavelength at 268 nm was used. INH nanoformulations were prepared by double emulsion solvent evaporation te

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29

Shinde, Sandip S., Kim-Viktoria Bolik, Simone Maschauer, and Olaf Prante. "18F-Fluorination Using Tri-Tert-Butanol Ammonium Iodide as Phase-Transfer Catalyst: An Alternative Minimalist Approach." Pharmaceuticals 14, no. 9 (2021): 833. http://dx.doi.org/10.3390/ph14090833.

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The 18F syntheses of tracers for positron emission tomography (PET) typically require several steps, including extraction of [18F]fluoride from H2[18O]O, elution, and drying, prior to nucleophilic substitution reaction, being a laborious and time-consuming process. The elution of [18F]fluoride is commonly achieved by phase transfer catalysts (PTC) in aqueous solution, which makes azeotropic drying indispensable. The ideal PTC is characterized by a slightly basic nature, its capacity to elute [18F]fluoride with anhydrous solvents, and its efficient complex formation with [18F]fluoride during su

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30

Mandal, Akash Pradip, and Prashanta Kumar Mandal. "Drug elution model of coronary stent: effects of stent embedment and binding of drug." International Journal of Biomedical Engineering and Technology 20, no. 2 (2016): 150. http://dx.doi.org/10.1504/ijbet.2016.074200.

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31

Issın, Ahmet. "Simple method for increasing drug elution from polymethylmethacrylate bone cement." Joint Diseases and Related Surgery 28, no. 2 (2017): 100–106. http://dx.doi.org/10.5606/ehc.2017.54840.

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32

FitzGerald, James J. "Suppression of scarring in peripheral nerve implants by drug elution." Journal of Neural Engineering 13, no. 2 (2016): 026006. http://dx.doi.org/10.1088/1741-2560/13/2/026006.

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33

Hose, D. R., A. J. Narracott, B. Griffiths, et al. "A Thermal Analogy for Modelling Drug Elution from Cardiovascular Stents." Computer Methods in Biomechanics and Biomedical Engineering 7, no. 5 (2004): 257–64. http://dx.doi.org/10.1080/10255840412331303140.

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34

Spiliopoulos, Stavros, Nikiforos Vasiniotis Kamarinos, and Elias Brountzos. "Current evidence of drug-elution therapy for infrapopliteal arterial disease." World Journal of Cardiology 11, no. 1 (2019): 13–23. http://dx.doi.org/10.4330/wjc.v11.i1.13.

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35

Kim, Wan-Tae, and Won-Youl Choi. "Optical Interference of TiO2 Nanotube Arrays for Drug Elution Sensing." Science of Advanced Materials 10, no. 2 (2018): 283–87. http://dx.doi.org/10.1166/sam.2018.2971.

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36

Tzafriri, Abraham R., Adam Groothuis, G. Sylvester Price, and Elazer R. Edelman. "Stent elution rate determines drug deposition and receptor-mediated effects." Journal of Controlled Release 161, no. 3 (2012): 918–26. http://dx.doi.org/10.1016/j.jconrel.2012.05.039.

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37

Abjean, J. P. "Screening of Chloramphenicol Residues in Pork Muscle by Planar Chromatography." Journal of AOAC INTERNATIONAL 77, no. 5 (1994): 1101–4. http://dx.doi.org/10.1093/jaoac/77.5.1101.

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Abstract A rapid planar chromatographic method is described for the qualitative determination of chloramphenicol residues in muscle. The drug is extracted with ethyl acetate and purified by solid-phase extraction. After elution, the collected phase is evaporated to dryness. The residue is dissolved in methanol, spotted on a silica gel plate, and chromato-graphed. After elution, the chloramphenicol is visualized after reduction with fluorescamine. This method detects chloramphenicol in meat at 10 μg/kg and has a sample throughput of about 25 samples per analyst per day.

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38

Guo, Peng, Qiucheng Liang, Juntao Zheng, et al. "Simultaneous determination of canrenone, digoxin and tolvaptan by UHPLC–MS/MS: application in heart failure patients." Bioanalysis 12, no. 9 (2020): 569–82. http://dx.doi.org/10.4155/bio-2020-0037.

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Aim: Heart failure patients are frequently given comedication of digoxin and diuretics like spironolactone and tolvaptan. A UHPLC–MS/MS assay for determining canrenone (main active metabolite of spironolactone), digoxin and tolvaptan simultaneously should be developed so as to support related drug–drug interaction studies. Results: A UHPLC–MS/MS method for simultaneous determination of these three drugs in human plasma was established and fully verified as per CFDA guidelines. Chromatographic separation was achieved using a 4-min isocratic elution. Mass analyses were performed under positive e

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39

Lai, Chi-Kong, Ting Lee, Kam-Ming Au, and Albert Yan-Wo Chan. "Uniform solid-phase extraction procedure for toxicological drug screening in serum and urine by HPLC with photodiode-array detection." Clinical Chemistry 43, no. 2 (1997): 312–25. http://dx.doi.org/10.1093/clinchem/43.2.312.

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Abstract In this HPLC–diode-array detection method for toxicological drug screening, a mixed-mode solid-phase extraction procedure is optimized for isolation of a broad range of drugs from serum and urine. Basic, neutral, and weakly acidic drugs are uniformly recovered. The extract from the solid-phase cartridge is readily injected to a reversed-phase HPLC column for separation by gradient elution. Unknown drugs and metabolites in urine and serum samples from acute drug poisoning cases are rapidly identified by matching their retention times and ultraviolet spectra with hundreds of reference c

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40

Di Trani, Nicola, Antonia Silvestri, Yu Wang, Danilo Demarchi, Xuewu Liu, and Alessandro Grattoni. "Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes Elution." Pharmaceutics 12, no. 7 (2020): 679. http://dx.doi.org/10.3390/pharmaceutics12070679.

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Individualized long-term management of chronic pathologies remains an elusive goal despite recent progress in drug formulation and implantable devices. The lack of advanced systems for therapeutic administration that can be controlled and tailored based on patient needs precludes optimal management of pathologies, such as diabetes, hypertension, rheumatoid arthritis. Several triggered systems for drug delivery have been demonstrated. However, they mostly rely on continuous external stimuli, which hinder their application for long-term treatments. In this work, we investigated a silicon nanoflu

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Kim, Wan-Tae, Kyeong-Han Na, Jae-Kwan Lee, Insan Jang, Dong-Soon Choi, and Won-Youl Choi. "Porous TiO2 Nanotube Arrays for Drug Loading and Their Elution Sensing." Journal of Nanoscience and Nanotechnology 19, no. 3 (2019): 1743–48. http://dx.doi.org/10.1166/jnn.2019.16243.

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42

Oh, Seunghan, Kyung-Suk Moon, Joo-Hee Moon, Ji-Myung Bae, and Sungho Jin. "Visible Light Irradiation-Mediated Drug Elution Activity of Nitrogen-Doped TiO2Nanotubes." Journal of Nanomaterials 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/802318.

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We have developed nitrogen-dopedTiO2nanotubes showing photocatalytic activity in the visible light region and have investigated the triggered release of antibiotics from these nanotubes in response to remote visible light irradiation. Scanning electron microscopy (SEM) observations indicated that the structure ofTiO2nanotubes was not destroyed on the conditions of 0.05 and 0.1 M diethanolamine treatment. The results of X-ray photoelectron spectroscopy (XPS) confirmed that nitrogen, in the forms of nitrite (NO2-) and nitrogen monoxide (NO), had been incorporated into theTiO2nanotube surface. A

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43

Parks, Owen W., and Robert C. Doerr. "Liquid Chromatographic Determination of Zoalene and Its Metabolites in Chicken Tissues with Electrochemical Detection." Journal of AOAC INTERNATIONAL 69, no. 1 (1986): 70–71. http://dx.doi.org/10.1093/jaoac/69.1.70.

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Abstract A procedure is described for the quantitation of Zoalene (3,5-dinitro-o-toluamide) and its 2 major monoamino metabolites in chicken tissues. The method includes blender extraction of tissue with chloroformethyl acetate (1 + 1), adsorption of the drug and metabolites on neutral alumina, and subsequent elution of the residues with pH 3.5 formate buffer-methanol (6.5 + 3.5). Recovered residues were separated on a 5 μ C18 column with the alumina eluting solvent as the LC mobile phase. The parent drug and metabolites were detected and quantitated with an electrochemical detector in the red

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44

MATHIVANAR, RANJINI, NEIL ANDERSON, DEIRDRE HARMAN, MICHAEL SKALSKY, and MICHAEL NG. "In Vivo Elution Rate of Drug Eluting Ceramic Leads with a Reduced Dose of Dexamethasone Sodium Phosphate." Pacing and Clinical Electrophysiology 13, no. 12 (1990): 1883–86. http://dx.doi.org/10.1111/j.1540-8159.1990.tb06909.x.

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45

Chow, Benjamin, Alex Baume, Peter Lok, et al. "Development of 3D Antibiotic-Eluting Bioresorbable Scaffold with Attenuating Envelopes." Journal of Biomimetics, Biomaterials and Tissue Engineering 15 (October 2012): 55–62. http://dx.doi.org/10.4028/www.scientific.net/jbbte.15.55.

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Thick Section 3D Bioresorbable Scaffolds Are Proposed as a Potential Alternative to Biologic Skin Grafts and Supportive Fillers for Non-Healing Chronic Wound Ulcers. Synthetic Bioresorbable Scaffolds Avoid Human and Animal Derived Contamination Risks, Provide Feasible Shelf Life, Availability and Cost, and Act as a Consistent Platform for Localized Drug Elution. A Bioresorbable Polyester-Based Scaffold (Infilon™) Was Investigated as a Drug Delivery Vehicle for Chloramphenicol Antibiotic (CAP) Combined with a Bioactive Envelope. the Effect of Varying Envelope Protocols on Antibiotic Elution Pro

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Ganz, Cornelia, and Thomas Gerber. "Bone Substitutes as a Drug Delivery of Antibiotics." Key Engineering Materials 631 (November 2014): 321–25. http://dx.doi.org/10.4028/www.scientific.net/kem.631.321.

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The aim of the present study was the in vitro investigation of a synthetic bone graft substitute loaded with individual antibiotics for the treatment of osteomyelitis and infectious bone disease. The elution of gentamicin, an aminoglycoside antibiotic, from the NanoBone® products NanoBone® S granules (NBG) and lyophilized NanoBone® (NBP) putty was tested over a period of one week. An indirect photometrically-based detection system was used to measure the released antibiotic concentration. Both materials showed very different release behaviour. After one day lyophilized NanoBone® putty delivere

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Anderson, N., W. J. Buykx, E. Drabarek, R. Mathivanar, K. D. Reeve, and M. Skalsky. "Drug Elution form Porous Ceramic Components for Threshold Reduction in Pacemaker Applications." Key Engineering Materials 53-55 (January 1991): 120–23. http://dx.doi.org/10.4028/www.scientific.net/kem.53-55.120.

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Hooker, Jared B., and Beau M. Hawkins. "Critical limb ischemia update and the evolving role of drug-elution technologies." Expert Review of Cardiovascular Therapy 15, no. 12 (2017): 891–96. http://dx.doi.org/10.1080/14779072.2017.1408409.

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Laurenti, Marco, Marta Grochowicz, Elena Dragoni, Marco Carofiglio, Tania Limongi, and Valentina Cauda. "Biodegradable and Drug-Eluting Inorganic Composites Based on Mesoporous Zinc Oxide for Urinary Stent Applications." Materials 13, no. 17 (2020): 3821. http://dx.doi.org/10.3390/ma13173821.

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Conventional technologies for ureteral stent fabrication suffer from major inconveniences such as the development of encrustations and bacteria biofilm formation. These drawbacks typically lead to the failure of the device, significant patient discomfort and an additional surgery to remove and replace the stent in the worst cases. This work focuses on the preparation of a new nanocomposite material able to show drug elution properties, biodegradation and eventually potential antibacterial activity. Poly(2-hydroxyethyl methacrylate) or the crosslinked poly(2-hydroxyethyl methacrylate)-co-poly(a

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Kita, Ashley, Johnny Saldate, Courtney Chang, et al. "Implantable Drug Reservoir Devices for Inner Ear Delivery of Pharmacotherapeutics." Otolaryngology–Head and Neck Surgery 163, no. 4 (2020): 791–98. http://dx.doi.org/10.1177/0194599820930229.

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Objective Cisplatin is a platinum-based chemotherapeutic drug that secondarily induces toxicity in inner ear sensory epithelia, contributing to auditory and vestibular dysfunction. We describe the creation of a drug reservoir device (DRD) to combat this ototoxicity for the duration of chemotherapy. As ototoxic side effects of chemotherapy may limit an oncologist’s ability to prescribe first-line agents such as cisplatin, mitigating such devastating effects through prolonged topical therapy would be tremendously valuable. Study Design We investigated (1) the ability of an electrospun polylactic

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