Relevant bibliographies by topics / Drug-excipient interaction

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Drug-excipient interaction'

Author: Grafiati
Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Drug-excipient interaction"

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Drebushchak, V. A., Tatyana P. Shakhtshneider, Svetlana A. Apenina, Alevtina S. Medvedeva, Líubov’ P. Safronova, and V. V. Boldyrev. "Thermoanalytical investigation of drug–excipient interaction." Journal of Thermal Analysis and Calorimetry 86, no. 2 (2006): 303–9. http://dx.doi.org/10.1007/s10973-005-7440-y.

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Drebushchak1, V. A., T. P. Shakhtshneider, S. A. Apenina, et al. "Thermoanalytical investigation of drug-excipient interaction." Journal of Thermal Analysis and Calorimetry 84, no. 3 (2006): 643–49. http://dx.doi.org/10.1007/s10973-005-9990-4.

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Nisar, Jan, Mudassir Iqbal, Munawar Iqbal, et al. "Decomposition Kinetics of Levofloxacin: Drug-Excipient Interaction." Zeitschrift für Physikalische Chemie 234, no. 1 (2020): 117–28. http://dx.doi.org/10.1515/zpch-2018-1273.

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AbstractThe present study is focused on the thermal decomposition of Levofloxacin in the absence and presence of different excipients (sodium starch glycolate, magnesium stearate, microcrystalline cellulose and lactose using Thermogravimetry (TG). Fourier Transform Infra Red Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) were used to study the possible drug – excipient interaction. It has been shown that the interaction of the first three excipients (sodium starch glycolate, magnesium stearate, and microcrystalline cellulose) with Levofloxacin is physical in nature. Lactose wa
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Chandran, I., and Pichandy prasanna. "Drug - Excipient interaction studies of loperamide loaded in polsorbate 80 liposomes." Oriental Journal of Chemistry 31, no. 4 (2015): 2201–6. http://dx.doi.org/10.13005/ojc/310443.

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Al-Rifai, Nafisah, Anas Alshishani, Bahruddin Saad, et al. "Synthesis, Isolation, Identification and Characterization of a Drug-Excipient Interaction Degradation Impurity in Pramipexole by HPLC, LC/MS and NMR." Separations 10, no. 1 (2022): 7. http://dx.doi.org/10.3390/separations10010007.

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A drug-excipient interaction impurity associated with the degradation process of pramipexole was isolated. The impurity was detected during the stability study of pramipexole extended-release tablets. It was found at a relative retention time of 0.88 with respect to pramipexole, using the pramipexole gradient HPLC-UV detection method described in the USP. The structure of the impurity was identified and fully characterized using high resolution mass spectrometry, IR and NMR techniques, as presented herein. The degradation impurity was identified as (S)-N2-(methoxymethyl)-N6-propyl-4,5,6,7-tetr
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Xiao, Yuxuan, Haiyu Zheng, Meng Du, and Zhe Zhang. "Investigation on the Potential Application of Na-Attapulgite as an Excipient in Domperidone Sustained-Release Tablets." Molecules 27, no. 23 (2022): 8266. http://dx.doi.org/10.3390/molecules27238266.

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In this study, Na-attapulgite was explored as an excipient to prepare domperidone sustained-release tablets and test them in accordance with United States Pharmacopoeia requirements. Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC) were employed to explore the compatibility between Na-attapulgite and domperidone. The XRD and DSC show no interaction between the drug and Na-attapulgite. The FTIR spectrum indicates a shift in the absorption of N-H in the drug molecule, which can be explained by the hydrogen bonding interact
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Tita, Ioana Cristina, Lavinia Lupa, Bogdan Tita, Roxana Liana Stan, and Laura Vicas. "Compatibility Studies of Valsartan with Different Pharmaceutical Excipients." Revista de Chimie 70, no. 7 (2019): 2590–600. http://dx.doi.org/10.37358/rc.19.7.7386.

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Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimet
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Tandel, D. B., P. A. Shah, K. G. Patel, M. C. Gohel, V. T. Thakkar, and T. R. Gandhi. "IMPROVEMENT OF DISSOLUTION RATE OF FEBUXOSTAT USING HYBRID TECHNIQUE OF SPHERICAL CRYSTALLIZATION AND SOLID DISPERSION." INDIAN DRUGS 52, no. 09 (2015): 32–39. http://dx.doi.org/10.53879/id.52.09.10274.

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The present study was carried out with an aim to improve dissolution rate of febuxostat (FBX, BCSclass II) drug. Spherical agglomerates were prepared by hybrid technique of spherical crystallization and solid dispersion using different ratios of FBX and polymer (PVP K30, HPMC E3LV and chitosan). Drug excipient compatibility study was evaluated by Fourier transform infrared spectroscopy and X-ray diffractometry. Scanning electron microscopy was used for measurement of size of agglomerate. In vitro dissolution study of prepared spherical agglomerates was compared with untreated FBX and marketed
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Alburyhi, Mahmoud M., Abdalwali A. Saif, and Randa M. Saif. "PREFORMULATION STUDY OF CEFTRIAXONE AND CIPROFLOXACIN FOR LIPID BASED DRUG DELIVERY SYSTEMS." Electronic Journal of University of Aden for Basic and Applied Sciences 3, no. 4 (2022): 339–50. http://dx.doi.org/10.47372/ejua-ba.2022.4.204.

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Several tests should be performed to rule out any potential physical or chemical interactions between the active pharmaceutical ingredient and the various excipients that might be utilized in the manufacturing of the drug formula. Fourier Transform infrared spectroscopy is a simple technique for the detection of changes within excipient-drug mixtures. In addition to speeding up the aging process of drugs and their possible interactions with excipients, isothermal stress testing was achieved. In this study, Ceftriaxone sodium (CTX), and Ciprofloxacin hydrochloride (CIPRO) as active ingredients
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Dzitko, Jakub, Przemyslaw Zalewski, Daria Szymanowska, Piotr Garbacki, Magdalena Paczkowska, and Judyta Cielecka Piontek. "The Influence of Excipients on the Physicochemical and Biological Properties of a Bactericidal, Labile Ester Prodrug in a Salt Form – A Case Study of Cefetamet Pivoxil Hydrochloride." JOURNAL OF ADVANCES IN CHEMISTRY 15, no. 2 (2018): 6218–34. http://dx.doi.org/10.24297/jac.v15i2.7560.

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The article presents an innovative approach to a bactericidal drug design based on a cephem prodrug analogue – cefetamet pivoxil hydrochloride. The emergence of cefetamet pivoxil hydrochloride excipient systems (mannitol, hydroxypropyl methyl cellulose, pregelatinised starch, lactose monohydrate, magnesium stearate, polyvinylpyrrolidone) caused changes in the physicochemical properties of cefetamet pivoxil hydrochloride. They are significant for planning the development of an innovative pharmaceutical formulation. The biological activity profile of the prodrug was also modified. FTIR spectra w
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Dissertations / Theses on the topic "Drug-excipient interaction"

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CHOI, HONG JUN. "Exploring the influence of drug-excipient interaction on batch-to-batch variabilityin Seretide." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27465.

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Seretide® is a dry powder inhaler (DPI) that contains two drugs, fluticasone propionate (FP) and salmeterol xinafoate (SX). Batch-to-batch variability in vivo is known to exist amongst DPIs, although the exact cause is unknown. The lactose excipient in Seretide contains fines and is more soluble than FP (which is practically insoluble in water). The interaction between lactose fines and the drugs can vary. It has been suggested that it may influence deposition profiles in the lung, wettability, and dissolution. Such variability between batches, and upon storage, would lead to changes in pharma
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Gallo, Renata Cristina. "Estudos termoanalíticos do antihipertensivo β- bloqueador carvedilol: comportamento térmico, interação com excipientes e polimorfismo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-17042015-095846/.

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Estudos sobre o comportamento térmico, de interação fármaco-excipiente e sobre polimorfismo do Carvedilol (1-(9H-Carbazol-4-iloxi)-3-[[2-(2-metoxifenoxi)etil]amino]-2-propanol), um fármaco da família dos β-bloqueadores, frequentemente utilizado no tratamento de doenças do coração e isquemias foram desenvolvidos, usando as técnicas termoanalíticas termogravimetria (TG), termogravimetria derivada (DTG), análise térmica diferencial (DTA) e calorimetria exploratória diferencial (DSC), além de técnicas complementares como espectroscopia vibracional na região do infravermelho com transformada d
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Pinto, Mônia Aparecida Lemos. "Estudos termoanalíticos da carbamazepina: hidratação/desidratação, decomposição térmica e interações com excipientes empregados em formulações farmacêuticas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-01112012-144158/.

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A carbamazepina (5H-dibenz[b, f]azepina-5-carboxamida) é um anticonvulsivante frequentemente utilizado no Brasil e em vários países. Ela apresenta quatro formas polimórficas e um di-hidratado, sendo ativa a Forma III. Entretanto, essa forma é altamente higroscópica podendo converter-se ao di-hidratado, menos ativo biologicamente. Nesse trabalho propõem-se avaliar o comportamento térmico da forma hidratada, visando à recuperação da forma ativa, por aquecimento. Para tanto, foi feito um estudo do comportamento térmico por TG/DTG-DTA e DSC em atmosfera dinâmica de ar e nitrogênio que evidenciou u
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Gupta, Patel Salin. "MECHANISMS AND THERMODYNAMICS OF THE INFLUENCE OF SOLUTION-STATE INTERACTIONS BETWEEN HPMC AND SURFACTANTS ON MIXED ADSORPTION ONTO MODEL NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/103.

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Nanoparticulate drug delivery systems (NDDS) such as nanocrystals, nanosuspensions, solid-lipid nanoparticles often formulated for the bioavailability enhancement of poorly soluble drug candidates are stabilized by a mixture of excipients including surfactants and polymers. Most literature studies have focused on the interaction of excipients with the NDDS surfaces while ignoring the interaction of excipients in solution and the extent to which the solution-state interactions influence the affinity and capacity of adsorption. Mechanisms by which excipients stabilize NDDS and how this informati
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Thomas, Cedric. "Identification des contaminants présents à la surface de lactose à usage pharmaceutique et analyse de l’impact de leur présence sur les interactions avec différents principes actifs." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCK012/document.

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Dans le but d'accroître nos connaissances sur les poudres pour usage alimentaire ou pharmaceutique, nous proposons d'étudier l'effet des procédés de fabrication, de mise en forme, la granulation sur la réactivité des poudres. La première partie est consacrée à l'effet de pureté sur les interactions-Lactose Lactose et Lactose-API mesurées / quantifiée par des techniques de champ proche (AFM, SMM, MSAFM) sous atmosphère ambiante et dans des conditions de stress stockage. Dérivant une seconde partie de la partie précédente mettra en évidence les effets des interactions sur différentes formulation
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Book chapters on the topic "Drug-excipient interaction"

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Narang, Ajit S., Aaron Yamniuk, Limin Zhang, et al. "Drug Excipient Interactions." In Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_2.

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Lee, Carlos. "Addressing Drug–Excipient Interactions." In Sample Preparation of Pharmaceutical Dosage Forms. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9631-2_6.

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Narváez, Alfredo R., and Shyam V. Vaidya. "Protein—Surfactant Interactions at the Air-Water Interface." In Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_6.

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Narang, Ajit S., Divyakant Desai, and Sherif Badawy. "Impact of Excipient Interactions on Solid Dosage Form Stability." In Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_5.

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Panakanti, Ravikiran, and Ajit S. Narang. "Impact of Excipient Interactions on Drug Bioavailability from Solid Dosage Forms." In Excipient Applications in Formulation Design and Drug Delivery. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20206-8_10.

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Gorain, Bapi, Hira Choudhury, Manisha Pandey, Thiagarajan Madheswaran, Prashant Kesharwani, and Rakesh K. Tekade. "Drug–Excipient Interaction and Incompatibilities." In Dosage Form Design Parameters. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-814421-3.00011-7.

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"Drug–Excipient Interactions and Adduct Formation." In Organic Chemistry of Drug Degradation. The Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/bk9781849734219-00150.

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This chapter discusses drug product degradation caused by the interaction between the active pharmaceutical ingredient (API) and components other than the API, including counter ions (if the API is an acid or base), excipients, impurities and degradants of excipients, and leachable impurities. In the first category of direct drug-excipient interaction, the mechanisms of the Maillard reaction including the Amadori rearrangement are discussed, followed by several examples involving secondary amine drugs and excipients containing reducing-end sugars. This chapter also examines a number of case studies where drug degradation is caused by impurities (hydrogen peroxide, formaldehyde, etc.) and degradants of excipients.
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"2 Drug-Excipient Interaction Occurances During Solid Dosage Form Development." In Preformulation in Solid Dosage Form Development. CRC Press, 2008. http://dx.doi.org/10.3109/9780849360862-17.

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"Excipient Interactions." In Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems. CRC Press, 2006. http://dx.doi.org/10.1201/9781420004137-11.

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Christian Moreton, R. "Excipient Interactions." In Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems. CRC Press, 2006. http://dx.doi.org/10.1201/9781420004137.ch8.

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Journal articles
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