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Journal articles on the topic 'Drug-excipient interaction'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Drebushchak, V. A., Tatyana P. Shakhtshneider, Svetlana A. Apenina, Alevtina S. Medvedeva, Líubov’ P. Safronova, and V. V. Boldyrev. "Thermoanalytical investigation of drug–excipient interaction." Journal of Thermal Analysis and Calorimetry 86, no. 2 (2006): 303–9. http://dx.doi.org/10.1007/s10973-005-7440-y.

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Drebushchak1, V. A., T. P. Shakhtshneider, S. A. Apenina, et al. "Thermoanalytical investigation of drug-excipient interaction." Journal of Thermal Analysis and Calorimetry 84, no. 3 (2006): 643–49. http://dx.doi.org/10.1007/s10973-005-9990-4.

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Nisar, Jan, Mudassir Iqbal, Munawar Iqbal, et al. "Decomposition Kinetics of Levofloxacin: Drug-Excipient Interaction." Zeitschrift für Physikalische Chemie 234, no. 1 (2020): 117–28. http://dx.doi.org/10.1515/zpch-2018-1273.

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AbstractThe present study is focused on the thermal decomposition of Levofloxacin in the absence and presence of different excipients (sodium starch glycolate, magnesium stearate, microcrystalline cellulose and lactose using Thermogravimetry (TG). Fourier Transform Infra Red Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) were used to study the possible drug – excipient interaction. It has been shown that the interaction of the first three excipients (sodium starch glycolate, magnesium stearate, and microcrystalline cellulose) with Levofloxacin is physical in nature. Lactose wa

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Chandran, I., and Pichandy prasanna. "Drug - Excipient interaction studies of loperamide loaded in polsorbate 80 liposomes." Oriental Journal of Chemistry 31, no. 4 (2015): 2201–6. http://dx.doi.org/10.13005/ojc/310443.

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Al-Rifai, Nafisah, Anas Alshishani, Bahruddin Saad, et al. "Synthesis, Isolation, Identification and Characterization of a Drug-Excipient Interaction Degradation Impurity in Pramipexole by HPLC, LC/MS and NMR." Separations 10, no. 1 (2022): 7. http://dx.doi.org/10.3390/separations10010007.

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A drug-excipient interaction impurity associated with the degradation process of pramipexole was isolated. The impurity was detected during the stability study of pramipexole extended-release tablets. It was found at a relative retention time of 0.88 with respect to pramipexole, using the pramipexole gradient HPLC-UV detection method described in the USP. The structure of the impurity was identified and fully characterized using high resolution mass spectrometry, IR and NMR techniques, as presented herein. The degradation impurity was identified as (S)-N2-(methoxymethyl)-N6-propyl-4,5,6,7-tetr

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Xiao, Yuxuan, Haiyu Zheng, Meng Du, and Zhe Zhang. "Investigation on the Potential Application of Na-Attapulgite as an Excipient in Domperidone Sustained-Release Tablets." Molecules 27, no. 23 (2022): 8266. http://dx.doi.org/10.3390/molecules27238266.

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In this study, Na-attapulgite was explored as an excipient to prepare domperidone sustained-release tablets and test them in accordance with United States Pharmacopoeia requirements. Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC) were employed to explore the compatibility between Na-attapulgite and domperidone. The XRD and DSC show no interaction between the drug and Na-attapulgite. The FTIR spectrum indicates a shift in the absorption of N-H in the drug molecule, which can be explained by the hydrogen bonding interact

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Tita, Ioana Cristina, Lavinia Lupa, Bogdan Tita, Roxana Liana Stan, and Laura Vicas. "Compatibility Studies of Valsartan with Different Pharmaceutical Excipients." Revista de Chimie 70, no. 7 (2019): 2590–600. http://dx.doi.org/10.37358/rc.19.7.7386.

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Compatibility studies between active drugs and excipients are substantial in the pharmaceutical technology. Thermal analysis has been extensively used to obtain information about drug-excipient interactions and to perform pre-formulation studies of pharmaceutical dosage forms. The objective of the present study was to evaluate the compatibility of the valsartan (VALS) with pharmaceutical excipients of common use including diluents, binders, disintegrants, lubricants and solubilising agents. Thermogravimetry (TG), derivative thermogravimetry (DTG), but especially differential scanning calorimet

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Tandel, D. B., P. A. Shah, K. G. Patel, M. C. Gohel, V. T. Thakkar, and T. R. Gandhi. "IMPROVEMENT OF DISSOLUTION RATE OF FEBUXOSTAT USING HYBRID TECHNIQUE OF SPHERICAL CRYSTALLIZATION AND SOLID DISPERSION." INDIAN DRUGS 52, no. 09 (2015): 32–39. http://dx.doi.org/10.53879/id.52.09.10274.

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The present study was carried out with an aim to improve dissolution rate of febuxostat (FBX, BCSclass II) drug. Spherical agglomerates were prepared by hybrid technique of spherical crystallization and solid dispersion using different ratios of FBX and polymer (PVP K30, HPMC E3LV and chitosan). Drug excipient compatibility study was evaluated by Fourier transform infrared spectroscopy and X-ray diffractometry. Scanning electron microscopy was used for measurement of size of agglomerate. In vitro dissolution study of prepared spherical agglomerates was compared with untreated FBX and marketed

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Alburyhi, Mahmoud M., Abdalwali A. Saif, and Randa M. Saif. "PREFORMULATION STUDY OF CEFTRIAXONE AND CIPROFLOXACIN FOR LIPID BASED DRUG DELIVERY SYSTEMS." Electronic Journal of University of Aden for Basic and Applied Sciences 3, no. 4 (2022): 339–50. http://dx.doi.org/10.47372/ejua-ba.2022.4.204.

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Several tests should be performed to rule out any potential physical or chemical interactions between the active pharmaceutical ingredient and the various excipients that might be utilized in the manufacturing of the drug formula. Fourier Transform infrared spectroscopy is a simple technique for the detection of changes within excipient-drug mixtures. In addition to speeding up the aging process of drugs and their possible interactions with excipients, isothermal stress testing was achieved. In this study, Ceftriaxone sodium (CTX), and Ciprofloxacin hydrochloride (CIPRO) as active ingredients

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Dzitko, Jakub, Przemyslaw Zalewski, Daria Szymanowska, Piotr Garbacki, Magdalena Paczkowska, and Judyta Cielecka Piontek. "The Influence of Excipients on the Physicochemical and Biological Properties of a Bactericidal, Labile Ester Prodrug in a Salt Form – A Case Study of Cefetamet Pivoxil Hydrochloride." JOURNAL OF ADVANCES IN CHEMISTRY 15, no. 2 (2018): 6218–34. http://dx.doi.org/10.24297/jac.v15i2.7560.

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The article presents an innovative approach to a bactericidal drug design based on a cephem prodrug analogue – cefetamet pivoxil hydrochloride. The emergence of cefetamet pivoxil hydrochloride excipient systems (mannitol, hydroxypropyl methyl cellulose, pregelatinised starch, lactose monohydrate, magnesium stearate, polyvinylpyrrolidone) caused changes in the physicochemical properties of cefetamet pivoxil hydrochloride. They are significant for planning the development of an innovative pharmaceutical formulation. The biological activity profile of the prodrug was also modified. FTIR spectra w

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Patel, Rahul, James Barker, and Amr ElShaer. "Pharmaceutical Excipients and Drug Metabolism: A Mini-Review." International Journal of Molecular Sciences 21, no. 21 (2020): 8224. http://dx.doi.org/10.3390/ijms21218224.

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Conclusions from previously reported articles have revealed that many commonly used pharmaceutical excipients, known to be pharmacologically inert, show effects on drug transporters and/or metabolic enzymes. Thus, the pharmacokinetics (absorption, distribution, metabolism and elimination) of active pharmaceutical ingredients are possibly altered because of their transport and metabolism modulation from the incorporated excipients. The aim of this review is to present studies on the interaction of various commonly-used excipients on pre-systemic metabolism by CYP450 enzymes. Excipients such as

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Amaral Silva, Daniela, Raimar Löbenberg, and Neal Davies. "Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights." Journal of Pharmacy & Pharmaceutical Sciences 21, no. 1s (2018): 19s—31s. http://dx.doi.org/10.18433/jpps29745.

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PURPOSE: The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety, effectiveness and delivery of the drug. The 1968 phenytoin intoxication outbreak in Brisbane, Australia, is a classic example of an API–excipient interaction. When administered with CaSO4 the absorption of phenytoin was reduced due to an interaction between the API and the excipient. When CaSO4 was replaced by lactose, the amount of drug absorbed w

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Soni, Shashank, Veerma Ram, and Anurag Verma. "3 (2) Factorial Design Assisted Crushed Puffed Rice-HPMC-Chitosan based Hydrodynamically Balanced System of Metoprolol Succinate." Drug Delivery Letters 10, no. 3 (2020): 237–49. http://dx.doi.org/10.2174/2210303110999200408122629.

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Introduction: Hydrodynamically balanced system (HBS) possesses prolonged and continuous delivery of the drug to the gastrointestinal tract which improves the rate and extent of medications that have a narrow absorption window. The objective of this work was to develop a Hydrodynamically Balanced System (HBS) of Metoprolol Succinate (MS) as a model drug for sustained stomach specific delivery. Materials and Methods: Experimental batches were designed according to 3(2) Taguchi factorial design. A total of 9 batches were prepared for batch size 100 capsules each. Formulations were prepared by phy

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Masuda, Takaaki, Yasuo Yoshihashi, Etsuo Yonemochi, Kotaro Fujii, Hidehiro Uekusa, and Katsuhide Terada. "Cocrystallization and amorphization induced by drug–excipient interaction improves the physical properties of acyclovir." International Journal of Pharmaceutics 422, no. 1-2 (2012): 160–69. http://dx.doi.org/10.1016/j.ijpharm.2011.10.046.

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Gomathi, Thandapani, C. Govindarajan, Maximas H. Rose H.R., et al. "Studies on drug-polymer interaction, in vitro release and cytotoxicity from chitosan particles excipient." International Journal of Pharmaceutics 468, no. 1-2 (2014): 214–22. http://dx.doi.org/10.1016/j.ijpharm.2014.04.026.

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Cotton, M. L., D. W. Wu, and E. B. Vadas. "Drug-excipient interaction study of enalapril maleate using thermal analysis and scanning electron microscopy." International Journal of Pharmaceutics 40, no. 1-2 (1987): 129–42. http://dx.doi.org/10.1016/0378-5173(87)90058-5.

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Arsul, V. A., S. Lahoti, P. K. Sharma, and B. Shrivastava. "EVALUATION OF TRIBULUS TERRESTRIS MUCILAGE AS BINDER IN TABLET FORMULATIONS." INDIAN DRUGS 52, no. 07 (2015): 10–17. http://dx.doi.org/10.53879/id.52.07.10336.

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The aim of this study is to develop an economic and effective natural excipient that can be used as an alternative in formulation of tablets. Tribulus terrestris (Zygophyllaceae) is a herbaceous weed native throughout India and mucilage is derived from the freshly dried and coarsely powdered leaves. phytochemical and physiochemical characteristics of mucilage were studied. Mucilage was used in 5 different concentrations (10, 15, 20, 25, and 30% w/V). Metoprolol tartrate was used as model drug for formulation. The DSC and FTIR of drug and mucilage indicate no chemical interaction. The propertie

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Chowdhury, Sonia, Mandava Nithin Babu, K. Ankitha, B. Shirisha, Madhurika Sirigadi, and Esarapu Kavya. "A comparative study on effect of polymers on release kinetics glimepiride matrix tablet." Pharmaceutical and Biological Evaluations 4, no. 2 (2017): 103. http://dx.doi.org/10.26510/2394-0859.pbe.2017.16.

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Objective: The Present investigation was performed to find out the effect of synthetic and natural polymers on the release properties of glimepiride matrix tablet. Glimepiride is a first third generation sulphonyl urea agent for the treatment of type- II diabetes mellitus. Methocel K15M, Olibanum Gum were used as key release modifying polymers.Methods: Nine formulations were prepared taking different concentration of natural and synthetic polymers, The drug excipient mixtures were subjected to pre-compression studies. The tablets were prepared by direct compression method; all formulations wer

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V, Kishan, Ramireddy Amarnath Reddy, and Ramesh Bomma. "Drug-Excipient Interaction during Formulation Development, in vitro andin vivo Evaluation of Gastroretentive Drug Delivery System for Nizatidine." International Journal of Pharmaceutical Sciences and Nanotechnology 6, no. 4 (2013): 2281–93. http://dx.doi.org/10.37285/ijpsn.2013.6.4.11.

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The present investigation dealswith the development and evaluation of floating tablets of nizatidine to prolong the gastric residence time, increase local delivery of drug to the H2-receptor of the parietal cell wall to reduce stomach acid secretion. The drug-excipient compatibility studies were conducted by using FTIR, DSC and visual observations. Citric acid inclusion in formulations resulted in incompatibility and the composition was modified to eliminate the problem of incompatibility. Floating matrix tablets of nizatidine were developed by direct compression method using hydroxypropyl met

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Patil, Purushottam, Malik Shaikh, and Paresh Mahaparale. "DEVELOPMENT AND EVALUATION OF ZIPRASIDONE LOADED SOLID SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM." INDIAN DRUGS 57, no. 08 (2020): 53–60. http://dx.doi.org/10.53879/id.57.08.12632.

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Solid self-micro emulsification technique is the new approach for poorly water-soluble and poorly bioavailable drugs by allowing the drug substance to be incorporated into the oil phase and thus having the ability to permeate the GI membrane to a faster extent. Oleic acid, Tween 80, methanol and colloidal silicon dioxide were used as penetrant, surfactant, co-surfactant and adsorbent, respectively. The interaction between drug and excipients was examined by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The results of DSC and FTIR studies did not re

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Sisinthy, Sreenivas Patro, and Shubbaneswarei Selladurai. "CINNARIZINE LIQUID SOLID COMPACTS: PREPARATION EVALUATION." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 150. http://dx.doi.org/10.22159/ijap.2019v11i1.30109.

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Objective: The objective of this research was to formulate cinnarizine tablets using the liquid-solid compact technique to enhance its solubility and dissolution rate.Methods: Cinnarizine liquid-solid compacts were formulated using propylene glycol as the non-volatile solvent, Neusilin US2 as the carrier material, Aerosil 200 as the coating material and croscarmellose sodium as the disintegrant. The interaction between drug and excipients were characterized by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies. Different batches of liquid, solid

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Mai, Yang, Liu Dou, Christine M. Madla, Sudaxshina Murdan, and Abdul W. Basit. "Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but Not Female Rats." Pharmaceutics 11, no. 5 (2019): 228. http://dx.doi.org/10.3390/pharmaceutics11050228.

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It is known that males and females respond differently to medicines and that differences in drug behaviour are due to inter-individual variability and sex specificity. In this work, we have examined the influence of pharmaceutical excipients on drug bioavailability in males and females. Using a rat model, we report that a portfolio of polyoxyethylated solubilising excipients (polyethylene glycol 2000, Cremophor RH 40, Poloxamer 188 and Tween 80) increase ranitidine bioavailability in males but not in females. The in vivo sex and excipient effects were reflected in vitro in intestinal permeabil

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Varun, Neetu, Arnab Dutta, and Chinmay Ghoroi. "Influence of surface interaction between drug and excipient in binary mixture for dry powder inhaler applications." Advanced Powder Technology 33, no. 3 (2022): 103443. http://dx.doi.org/10.1016/j.apt.2022.103443.

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Ghaderi, Faranak, Mahboob Nemati, Mohammad R. Siahi-Shadbad, Hadi Valizadeh, and Farnaz Monajjemzadeh. "Physicochemical evaluation and non-isothermal kinetic study of the drug–excipient interaction between doxepin and lactose." Powder Technology 286 (December 2015): 845–55. http://dx.doi.org/10.1016/j.powtec.2015.09.007.

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Chella, Naveen, Nataraj Narra, and Tadikonda Rama Rao. "Preparation and Characterization of Liquisolid Compacts for Improved Dissolution of Telmisartan." Journal of Drug Delivery 2014 (October 12, 2014): 1–10. http://dx.doi.org/10.1155/2014/692793.

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The objective of the present work was to obtain pH independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Liquisolid compacts were prepared using Transcutol HP as vehicle, Avicel PH102 as carrier, and Aerosil 200 as a coating material. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow properties, and general quality control tests of tablets using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD), angle of repose, and various

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Murillo-Fernández, Mac Arturo, Ernesto Montero-Zeledón, Ariadna Abdala-Saiz, José Roberto Vega-Baudrit, and Andrea Mariela Araya-Sibaja. "Interaction and Compatibility Studies in the Development of Olmesartan Medoxomil and Hydrochlorothiazide Formulations under a Real Manufacturing Process." Pharmaceutics 14, no. 2 (2022): 424. http://dx.doi.org/10.3390/pharmaceutics14020424.

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A drug–drug and drug–excipient interactions and compatibilities study was conducted for two fixed-dose combination (FDC) products containing olmesartan medoxomil (OLM)/hydrochlorothiazide (HCT) 20/12.5 mg and OLM/HCT 40/12.5 mg during their development including storage. The study consisted of the evaluation of samples retrieved during all stages of a real manufacturing process. Powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetry (TGA), Fourier transform infrared spectroscopy (FT-IR), and contact angle techniques were applied to the samples to determine i

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Ramya, V., Z. Abbas, and NGN Swamy. "FORMULATION AND EVALUATION OF EFAVIRENZ COMPACTS BY LIQUISOLID TECHNIQUE FOR SOLUBILITY ENHANCEMENT." INDIAN DRUGS 52, no. 04 (2015): 21–27. http://dx.doi.org/10.53879/id.52.04.10113.

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The aim of this study was to improve the bioavailability by enhancing the solubility of efavirenz, a poor water soluble, anti-viral drug by using liquisolid technique. Different liquisolid formulations were prepared by using various non-volatile hydrophilic solvents. Microcystalline cellulose (Avicel PH 102) and Aerosil 200 were used as carrier and coating materials respectively. Additives such as polyvinyl pyrrolidone, hydroxypropyl methylcellulose and hydroxypropyl guar were incorporated into the formulations, to improve dissolution characteristics. The prepared liquisolid compacts were eval

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Singh, Balwan, and Manish Sharma. "0Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems for Candesartan Cilexetil." International Journal of Pharmaceutical Sciences and Nanotechnology 15, no. 2 (2022): 5844–54. http://dx.doi.org/10.37285/ijpsn.2022.15.2.3.

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Introduction: Candesartan cilexetil is an angiotensin receptor blocker prescribed for hypertension management. However the drug belonging to BCS class II has low solubility and in turn low bioavailability. Lipid-based drug delivery systems are gaining wide attention in the field of pharmaceutical formulations owing to their potential to enhance the solubility of poorly aqueous soluble drugs. Objective: “Present” work aimed to formulate and evaluate Candesartan cilexetil loaded Self-emulsifying drug delivery systems (SEDDS) as a potential antihypertensive drug delivery system by improving

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Jindal, K. C., R. S. Chaudhary, S. S. Gangwal, A. K. Singla, and S. Khanna. "High-performance thin-layer chromatographic method for monitoring degradation products of rifampicin in drug excipient interaction studies." Journal of Chromatography A 685, no. 1 (1994): 195–99. http://dx.doi.org/10.1016/0021-9673(94)00730-6.

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D.V. R. N., Bhikshapathi, Vishwaja M, Suthakaran R, Usha Sri B, and M. Ratan Seshagiri Rao. "Improvement of Solubility and Dissolution Rate of Simvastatin by Solid Dispersion Technique." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 6 (2019): 4964–700. http://dx.doi.org/10.37285/ijpsn.2019.12.6.3.

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The aim of present work is to enhance the solubility and bioavailability of Simvastatin by solid dispersion technique and characterize the same. Preliminary solubility studies were conducted to check the solubility in different polymers. Based on the results 20 formulations prepared by solvent evaporation method with varying ratios of Kleptose HPB, Soluplus, Kolliwax GMS II, Kolliphor P188 and PVPK-30. All the formulations were analyzed for solubility, percentage yield, drug content and in vitro drug release. The formulation SD20 with enhanced solubility of 20.05 ± 0.02μg/mL in Kolliwax GMS II

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Binkhathlan, Ziyad. "Cremophor EL Alters the Plasma Protein Binding and Pharmacokinetic Profile of Valspodar in Rats." Drug Research 67, no. 10 (2017): 591–95. http://dx.doi.org/10.1055/s-0043-111411.

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AbstractCremophor EL is a nonionic surfactant widely used in pharmaceutical formulations. Nonetheless, there are several reports on the influence of this excipient on the protein binding, pharmacokinetics, and pharmacodynamics of drugs. Valspodar is an investigational non-immunosuppressive derivative of cyclosporine A, used in clinical trials for treatment of multidrug resistant tumors. The formulation of valspodar (Amdray®) contains cremophor EL and ethanol as solubilizing agents. The main aim of the current study was to assess the plasma protein binding (in vitro) and the pharmacokinetic pro

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Wen, Chengming, Haoyang Hu, Wenwen Zhang, Xin Liu, Xuehua Jiang, and Ling Wang. "Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL−35." Pharmaceutics 13, no. 9 (2021): 1492. http://dx.doi.org/10.3390/pharmaceutics13091492.

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Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the activity of metabolic enzymes and drug transporters; however, the effects of PEs on CYP2C8 and its interaction potential with drugs remain unclear. In this study, we evaluated the effects of Tween 80 and EL−35 on CYP2C8 in vitro and further investigated their impacts on the PK of paclitaxel (PTX) in rats after single or multiple doses. The in vitro study indicated that Tween 80 and EL−35 inhibited CYP2C8 activity in human and rat liver microsomes. EL−35 also d

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T, Balakrishna, Vidyadhara S, Murthy Tegk, Ramu A, and Sasidhar Rlc. "FORMULATION AND EVALUATION OF ESOMEPRAZOLE FAST DISSOLVING BUCCAL FILMS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 193. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.27321.

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Objective: The present study deals with the formulation and evaluation of fast dissolving buccal films for effective treatment option in the gastroesophageal reflux disease.Methods: Esomeprazole fast dissolving buccal films are a convenient formulation of which can be taken with or without water. In the present investigation, polyvinyl alcohol and polyvinylpyrrolidone were used as film-forming agents and polyethylene glycol 400 is taken as plasticizer. Solvent evaporation method was used for the preparation of fast dissolving buccal films.Results: The films were prepared and evaluated for film

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Omari, Derar M., and Yazan Akkam. "A study of drug-excipient interaction and drug product stability using dry (powder) film coating in comparison with conventional (aqueous) film coating." ACTA Pharmaceutica Sciencia 57, no. 3 (2019): 75. http://dx.doi.org/10.23893/1307-2080.aps.05719.

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Hartauer, K. J., and J. K. Guillory. "A Comparison of diffuse Reflectance Ft-Ir Spectroscopy and Dsc in the Characterization of a Drug-Excipient Interaction." Drug Development and Industrial Pharmacy 17, no. 4 (1991): 617–30. http://dx.doi.org/10.3109/03639049109044268.

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Y, Shravan Kumar, Shireesha G, and Harika S. "Formulation and Evaluation of Metoprolol Tartrate Sustained Release Matrix Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 5 (2019): 4865–671. http://dx.doi.org/10.37285/ijpsn.2019.12.5.7.

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The objective of the present work was to develop sustained release matrix tablets of Metoprolol tartrate using different polymers viz. Guar gum, Xanthan gum, Kondagogu gum and HPMC K100M. The release rates were modulated by combination of two different rates controlling material and triple mixture of two different rate controlling materials. After evaluation of physical properties of tablet, the in-vitro release study was performed in phosphate buffer pH 6.8 up to 12 hrs. Dissolution data was analyzed for release kinetics. It was observed that matrix tablets contained polymer Xanthan gum was s

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Sapate, K. A., P. V. Dangre, and M. D. Godbole. "FORMULATION AND STATISTICAL OPTIMIZATION OF MULTIPARTICULATE LAFUTIDINE-LOADED GASTRORETENTIVE DELIVERY SYSTEM USING 32- FACTORIAL DESIGN." INDIAN DRUGS 51, no. 10 (2014): 43–54. http://dx.doi.org/10.53879/id.51.10.10169.

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The purpose of this research was to develop and optimize buoyant beads containing lafutidine by ionic-gelation method for gastroretentive delivery. The effect of two independent process variables like NaHCO 3: Polymer, Drug: Polymer ratio on % drug entrapment, % swelling and % drug release of buoyant beads containing lafutidine was optimized using 32 factorial designs. The observed responses coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency 78.76+0.27%, swelling 69.90+0.13%, cumulative drug release 69.00+0.36% a

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Srikanth Reddy, Poreddy, Penjuri Subhash Chandra Bose, Vuppula Sruthi, and Damineni Saritha. "INVESTIGATION OF KONDAGOGU GUM TO DEVELOP TRANSDERMAL FILM OF REPAGLINIDE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 4 (2018): 440. http://dx.doi.org/10.22159/ajpcr.2018.v11i4.24873.

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Objective: In the present study, an attempt was made to develop polymeric blend transdermal patch of repaglinide using hydroxypropyl methyl cellulose (HPMC) K4M and kondagogu gum.Methods: A series of repaglinide drug-incorporated HPMC K4M-kondagogu gum matrix films were prepared by solvent casting method. The prepared transdermal films were evaluated for various parameters such as thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, and drug excipient compatibility.Results: The Fourier-transform infrared spe

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Tiwari, Pallavi. "RAFT FORMING BUOYANT pH DEPENDENT THIXOTROPIC GELLING SYSTEMS INCORPORATED WITH GELUCIRE 43/01 AS A POTENTIAL STOMACH SPECIFIC DRUG DELIVERY SYSTEM FOR FAMOTIDINE." Journal of Applied Pharmacy 7 (2015): 156. http://dx.doi.org/10.21065/19204159.7.156.

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Famotidine (FMT) is known as a histamine blocker (H2) that inhibits stomach acid production and it is commonly used in the treatment of peptic ulcer disease and gastric-esophageal reflux disease. It has a short half life (2.5-3.5 hours), low bioavailability (40-45%). It has excellent solubility in acidic pH just reverse in alkaline pH. Therefore an attempt has been made to develop raft buoyant gastro-retentive sustains release delivery system with in situ gelling property which is based on thixotropy behavior. Twelve formulations (Excluding two controlled formulations i.e. F and F*) were desig

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Al-dhahir, Rasha Khalid, and Myasar Al-kotaji. "FORMULATION OF ORALLY DISINTEGRATING TABLETS OF CINNARIZINE BY USING DIRECT COMPRESSION METHOD." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 117. http://dx.doi.org/10.22159/ijap.2019v11i1.29599.

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Objective: The aim of this work was to formulate and evaluate orally disintegrating tablets of cinnarizine that were prepared by direct compression method using different types of diluents and super disintegrants. The rationale behind this work was to accelerate the disintegration of the tablet to provide rapid dissolution, quick action and enhanced bioavailability of the drug.Methods: The tablets were prepared by direct compression method using different types of diluents as mannitol, microcrystalline cellulose (MCC), and lactose. Different super disintegrants were used such as crospovidone (

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Okunlola, A., and T. A. Gbadamosi. "Compaction and Tableting Behavior of a Novel Co-Processed Excipient in the Formulation of Metoprolol Succinate Tablets." Nigerian Journal of Pharmaceutical Research 16, no. 2 (2021): 127–42. http://dx.doi.org/10.4314/njpr.v16i2.4.

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Background: Pregelatinized starches exhibit good swelling and flow properties, imparting fast disintegration time but low mechanical strength in tablets. On the other hand, acacia gum acts as a binder in tablets by imparting high mechanical strength but prolonged disintegration time. Development of a co-processed excipient involving combination of the two excipients at sub-particle level will improve the functionality of the final product.Objective: To develop a direct compressible co-processed excipient with pregelatinized cocoyam starch and acacia gum and to evaluate its compaction behavior

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Rub, Malik Abdul, Naved Azum, Dileep Kumar, and Abdullah M. Asiri. "Interaction of TX-100 and Antidepressant Imipramine Hydrochloride Drug Mixture: Surface Tension, 1H NMR, and FT-IR Investigation." Gels 8, no. 3 (2022): 159. http://dx.doi.org/10.3390/gels8030159.

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Interfacial interaction amongst the antidepressant drug-imipramine hydrochloride (IMP) and pharmaceutical excipient (triton X-100 (TX-100-nonionic surfactant)) mixed system of five various ratios in dissimilar media (H2O/50 mmol·kg−1 NaCl/250 mmol·kg−1 urea) was investigated through the surface tension method. In addition, in the aqueous solution, the 1H-NMR, as well as FT-IR studies of the studied pure and mixed system were also explored and deliberated thoroughly. In NaCl media, properties of pure/mixed interfacial surfaces enhanced as compared with the aqueous system, and consequently the s

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Singh, Sukhwinder, Sukhmeet Singh Kamal, Amit Sharma, Daljit Kaur, Manoj Kumar Katual, and Rajesh Kumar. "Formulation and In-Vitro Evaluation of Solid Lipid Nanoparticles Containing Levosulpiride." Open Nanomedicine Journal 4, no. 1 (2017): 17–29. http://dx.doi.org/10.2174/1875933501704010017.

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Objectives: The present study aims on preparing Levosulpiride loaded solid lipid nanoparticles (SLNs) to reduce the dose, frequency of dosing, reduce side effects and to increase the bioavailable fraction of drug (<30% orally in general). Methods: Levosulpiride was characterized by preformulation studies like physical appearance, melting point, assay, calibration curve, FTIR analysis and DSC analysis. The calibration curve of the drug was prepared in pH 6.8 phosphate buffer. Two lipids (Stearic acid and Palmitic acid) were used as lipid phase to prepare SLNs. Factorial design (23) was appli

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Kodalkar, Swapnil J., Rohan A. Khutale, Sachin S. Salunkhe, Sachin S. Mali, and Sameer J. Nadaf. "Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 68–75. http://dx.doi.org/10.30750/ijpbr.2.1.11.

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In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and

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Sharma, N., and R. Awasthi. "DEVELOPMENT AND CHARACTERIZATION OF NOVEL GASTRORETENTIVE RAFT FORMING FLOATING FILM OF ATENOLOL." INDIAN DRUGS 52, no. 03 (2015): 15–23. http://dx.doi.org/10.53879/id.52.03.10157.

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The aim of present work was to develop a gastroretentive floating raft forming film of atenolol using solvent casting technique. The films were characterized in terms of drug-excipient compatibility by FTIR, drug content, swelling, folding endurance, thermal behaviour by DSC, effect of processing parameters on drug state (amorphous or crystalline) by X-ray diffraction (XRD), and in vitro drug release profiles. The results confirm that there was no interaction between the drug-polymers and fusion of drug crystals within the polymer matrix. Results of XRD indicate partial dissolution of drug wit

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Shahidulla, S. M., Mohib Khan, and K. N. Jayaveera. "DESIGN AND EVALUATION OF DOMPERIDONE FAST DISINTEGRATING TABLETS BY WET GRANULATION TECHNIQUES USING PLANTAGO OVATA MUCILAGE." INDIAN DRUGS 51, no. 06 (2014): 49–54. http://dx.doi.org/10.53879/id.51.06.10129.

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In the present study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by wet granulation method. In the study, fast disintegrating tablets of the drug using, Plantago ovata mucilage and Crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along with starch paste as a binder. The disintegrant was incorporated during the wet granulation process as an extra granular incorporation. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitr

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Shahidulla, S. M., Mohib Khan, and K. N. Jayaveera. "DESIGN AND EVALUATION OF DOMPERIDONE FAST DISINTEGRATING TABLETS BY WET GRANULATION TECHNIQUES USING PLANTAGO OVATA MUCILAGE." INDIAN DRUGS 51, no. 06 (2014): 49–54. http://dx.doi.org/10.53879/id.51.06.10129.

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In the present study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by wet granulation method. In the study, fast disintegrating tablets of the drug using, Plantago ovata mucilage and Crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along with starch paste as a binder. The disintegrant was incorporated during the wet granulation process as an extra granular incorporation. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitr

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Vimalson, D. Christopher, S. Parimalakrishnan, N. S. Jeganathan, and S. Anbazhagan. "SOLID DISPERSION TECHNIQUE TO ENHANCE THE SOLUBILITY AND DISSOLUTION OF FEBUXOSTAT AN BCS CLASS II DRUG." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 241. http://dx.doi.org/10.22159/ijap.2019v11i1.30539.

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Objective: The present study was aimed to enhance the solubility of poorly water-soluble drug (BCS Class II) Febuxostat using water-soluble polymers.Methods: Pre-formulation studies like drug excipient compatibility studies by Fourier-transform infrared spectroscopyDifferential scanning calorimetry and determination of saturation solubility of drug individually in various media like distilled water and pH 7.4 phosphate buffer. Solid dispersions of Febuxostat was prepared using Polyethylene glycol (PEG 6000) (fusion method) and Polyvinyl pyrrolidone (PVP K30) (solvent evaporation method) in var

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Bonsu, Martina Aduenimaa, Kwabena Ofori-Kwakye, Samuel Lugrie Kipo, Mariam El Boakye-Gyasi, and Mary-Ann Fosu. "Development of Oral Dissolvable Films of Diclofenac Sodium for Osteoarthritis Using Albizia and Khaya Gums as Hydrophilic Film Formers." Journal of Drug Delivery 2016 (May 30, 2016): 1–11. http://dx.doi.org/10.1155/2016/6459280.

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Oral dissolvable films (ODFs) of diclofenac sodium intended for osteoarthritis were prepared using Albizia and Khaya gums as hydrophilic film formers. The physicochemical properties of the gums were characterized and the gums were used to prepare diclofenac sodium ODFs (~50 mg/4 cm2 film) by solvent casting. The two gums showed satisfactory film forming properties. The physicomechanical properties, drug-excipient compatibility, and in vitro drug release of the films in phosphate buffer pH 6.8 were studied. Khaya gum had higher extraction yield, moisture content, insoluble matter and true densi

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Novickis, Richard W., Marcos V. Surmani Martins, Leila F. de Miranda, Roberto R. Ribeiro, Laureano Silva, and Antônio Hortêncio Munhoz Jr. "Development of Nanosystems to Release Atenolol." Advances in Science and Technology 86 (September 2012): 102–7. http://dx.doi.org/10.4028/www.scientific.net/ast.86.102.

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Abstract: The structure of aluminum monohydroxide resulting from synthesis by ammonium hydroxide with aluminum chloride (or aluminum nitrate, for example) by a sol-gel process, gives a purified and chemically inert material with many applications possibilities because of its great specific surface area. A pseudoboehmite is the choice in this project for adsorption/desorption of atenolol. The molecular interaction with the pseudoboehmite substrate was studied by FTIR (Infrared Spectroscopy), DSC (Scanning electron /TG Thermogravimetry), UV-vis (Ultraviolet-visible spectroscopy) and SEM (Scannin

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