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Journal articles on the topic 'Drug induced abnormalities'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Kozik, Teri M., Mary G. Carey, Salah S. Al-Zaiti, and Michele M. Pelter. "Drug Induced ECG Abnormalities." American Journal of Critical Care 24, no. 4 (2015): 365–66. http://dx.doi.org/10.4037/ajcc2015712.

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Piraccini, Bianca Maria, Matilde Iorizzo, and Antonella Tosti. "Drug-Induced Nail Abnormalities." American Journal of Clinical Dermatology 4, no. 1 (2003): 31–37. http://dx.doi.org/10.2165/00128071-200304010-00004.

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3

Piraccini, Bianca Maria, Matilde Iorizzo, Angela Antonucci, and Antonella Tosti. "Drug-induced nail abnormalities." Expert Opinion on Drug Safety 3, no. 1 (2004): 57–65. http://dx.doi.org/10.1517/14740338.3.1.57.

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4

Patton, W. Nigel, and Stephen B. Duffull. "Idiosyncratic Drug-Induced Haematological Abnormalities." Drug Safety 11, no. 6 (1994): 445–62. http://dx.doi.org/10.2165/00002018-199411060-00006.

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5

Gitlin, Norman. "DRUG-INDUCED HEPATIC VASCULAR ABNORMALITIES." Clinics in Liver Disease 2, no. 3 (1998): 591–606. http://dx.doi.org/10.1016/s1089-3261(05)70028-3.

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6

Mintzer, David M., Shira N. Billet, and Lauren Chmielewski. "Drug-Induced Hematologic Syndromes." Advances in Hematology 2009 (2009): 1–11. http://dx.doi.org/10.1155/2009/495863.

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Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes.Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias.Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplasti

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7

Kokot, Franciszek, and Lidia Hyla‑Klekot. "Drug‑induced abnormalities of potassium metabolism." Polish Archives of Internal Medicine 118, no. 7-8 (2008): 431–34. http://dx.doi.org/10.20452/pamw.442.

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8

Frazier, Kendall S. "Drug-induced Physeal Abnormalities in Preclinical Toxicity Studies." Toxicologic Pathology 45, no. 7 (2017): 869–75. http://dx.doi.org/10.1177/0192623317713319.

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Most toxic physeal changes are characterized microscopically by altered chondrocyte development, proliferation, or maturation in the growth plate and eventually result in disordered appositional bone growth. Many therapeutic drugs directly or indirectly target proteins involved in chondrocytic differentiation and maturation pathways, so toxic physeal injury has become increasingly common in preclinical toxicologic pathology. While physeal dysplasia has been associated with several different drug classes including bisphosphonates, vascular endothelial growth factor receptor inhibitors, fibrobla

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9

Sidhu, Harbir S., Nanda Venkatanarasimha, Gauraang Bhatnagar, Varut Vardhanabhuti, Bruce M. Fox, and Sri Priya Suresh. "Imaging Features of Therapeutic Drug–induced Musculoskeletal Abnormalities." RadioGraphics 32, no. 1 (2012): 105–27. http://dx.doi.org/10.1148/rg.321115041.

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10

Vasic, Nada, Branislava Milenkovic, Dragica Pesut, Ruza Stevic, and Dragana Jovanovic. "Drug induced lung disease - amiodarone in focus." Medical review 67, no. 9-10 (2014): 334–37. http://dx.doi.org/10.2298/mpns1410334v.

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More than 380 medications are known to cause pulmonary toxicity. Selected drugs that are important causes of pulmonary toxicity fall into the following classes: cytotoxic, cardiovascular, anti-inflammatory, antimicrobial, illicit drugs, miscellaneous. The adverse reactions can involve the pulmonary parenchyma, pleura, the airways, pulmonary vascular system, and mediastinum. Drug-induced lung diseases have no pathognomonic clinical, laboratory, physical, radiographic or histological findings. A drug-induced lung disease is usually considered a diagnosis of exclusion of other diseases. The diagn

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11

Manne, Vimala, and Padmaja Pinjala. "Drug eruptions and hepatic involvement: a study." International Journal of Research in Dermatology 4, no. 4 (2018): 501. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20183819.

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<p class="abstract"><strong>Background:</strong> Assessment by liver biopsy remains the gold standard in defining drug induced liver disease. Liver biopsy is an invasive procedure. Hence, a technique that is simpler is required to detect drug induced liver dysfunction. The profile of liver function tests (LFT) abnormalities, provides an initial guide to the clinical syndrome of drug induced hepatotoxicity. This study attempts to draw a possible correlation as well as to derive insight into the involvement of liver in drug eruptions through simple liver function tests.</p&g

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Diamanti-Kandarakis, E., L. Duntas, G. A. Kanakis, et al. "DIAGNOSIS OF ENDOCRINE DISEASE: Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview." European Journal of Endocrinology 181, no. 2 (2019): R73—R105. http://dx.doi.org/10.1530/eje-19-0154.

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In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities via different mechanisms, including direct alteration of hormone production, changes in the regulation of the feedback axis, on hormonal transport, binding and signaling, as well as similar changes to counter-regulatory hormone systems. Furthermore, drugs can interfere with the hormonal assays, leading to erroneous laboratory results that disorientate clinicians from the

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13

Pesco-Koplowitz, Luana, Gary Gintant, Robert Ward, Dominique Heon, Muriel Saulnier, and Jeff Heilbraun. "Drug-induced cardiac abnormalities in premature infants and neonates." American Heart Journal 195 (January 2018): 14–38. http://dx.doi.org/10.1016/j.ahj.2017.07.014.

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14

Yeomans, David, Joanna Moncrieff, and Rhodri Huws. "Drug-centred psychopharmacology: a non-diagnostic framework for drug treatment†." BJPsych Advances 21, no. 4 (2015): 229–36. http://dx.doi.org/10.1192/apt.bp.114.013094.

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SummaryWe propose a ‘drug-centred’ framework for understanding the nature of drug treatment in psychiatry. In contrast to the prevailing ‘disease-centred’ model, which suggests that drugs work by targeting underlying abnormalities, the drug-centred model maintains that drugs exert their effects through their psychoactive properties. According to this view, distinctive drug-induced alterations to normal cognition, emotion and behaviour can modify the manifestations of mental disorders independent of diagnosis or aetiological theory. The drug-centred approach already forms the basis of some curr

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15

Aithal, P. G., and C. P. Day. "The natural history of histologically proved drug induced liver disease." Gut 44, no. 5 (1999): 731–35. http://dx.doi.org/10.1136/gut.44.5.731.

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BACKGROUNDThe long term outcome of drug related liver disease is unknown.AIMSTo study the natural history of histologically proved drug induced hepatotoxicity.METHODS110 patients with liver biopsies coded either as drug induced liver disease or hepatitis/cholestasis of unknown aetiology were identified from hospital records 1978–1996. Review of case notes and histology identified 44 patients with definite drug induced hepatotoxicity. Forty surviving patients were invited to attend a follow up clinic. History, examination, full liver screen, and isotope and ultrasound liver scans were repeated

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16

Chau, Vicky, Sadhana Prasad, Dwight Stewart, and George Heckman. "Creutzfeldt–Jakob disease-like syndrome induced by gabapentin toxicity." Ageing Research 1, no. 1 (2010): 3. http://dx.doi.org/10.4081/ar.2010.e3.

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Patients with Creutzfeldt–Jakob disease (CJD) may exhibit characteristic abnormalities on the electroencephalogram (EEG). However, these abnormalities have been associated with a number of cases of drug toxicity. We report a case of CJD-like syndrome associated with gabapentin. A 78-year-old man was hospitalized for recurrent falls. Three months prior to admission, gabapentin was prescribed to treat symptoms of trigeminal neuralgia. The patient subsequently presented with a two-month history of worsening gait abnormalities, negative myoclonus, and cognitive impairment. The EEG showed diffuse b

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17

Lameris, Anke L., Leo A. Monnens, René J. Bindels, and Joost G. J. Hoenderop. "Drug-induced alterations in Mg2+ homoeostasis." Clinical Science 123, no. 1 (2012): 1–14. http://dx.doi.org/10.1042/cs20120045.

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Magnesium (Mg2+) balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a broad variety of drugs. Diuretics, modulators of the EGFR (epidermal growth factor receptor), proton pump inhibitors, antimicrobials, calcineurin inhibitors and cytostatics may all cause hypomagnesaemia, potentially leading to tetany, seizures and cardiac arrhythmias. Conversely, high doses of Mg2+ salts, frequently administered as an antacid or a laxative, may lead to hypermagnesaemia causing various cardiovascular and neuromuscular abnormalities. A bet

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18

Mukarram, O., Y. Hindi, G. Catalasan, and J. Ward. "Loperamide Induced Torsades de Pointes: A Case Report and Review of the Literature." Case Reports in Medicine 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/4061980.

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Abuse of over the counter drugs often gets overlooked by health care providers. Loperamide is one such over the counter drug that is often abused by drug addicts. We present here a case of a young male attaining euphoria from taking massive doses of loperamide. He developed Torsades de Pointes and subsequent cardiac arrest. We found similarities in the progression of myocardial electrical conduction abnormalities among loperamide and other previously known arrhythmogenic drugs. We intend to raise concern over the ease of availability of such drugs over the counter and increase the index of sus

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19

Cubeddu, Luigi. "Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias." Current Cardiology Reviews 12, no. 2 (2016): 141–54. http://dx.doi.org/10.2174/1573403x12666160301120217.

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20

Kulshreshtha, Bindu, Isha Pahuja, Deepak Kothari, et al. "Menstrual cycle abnormalities in patients with prolactinoma and drug-induced hyperprolactinemia." Indian Journal of Endocrinology and Metabolism 21, no. 4 (2017): 545. http://dx.doi.org/10.4103/ijem.ijem_515_16.

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21

Deng, Mingqun, Han Wu, Miao Yu, Yi Tian, Yuxiu Li, and Xinhua Xiao. "Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS." International Journal of Endocrinology 2019 (October 3, 2019): 1–8. http://dx.doi.org/10.1155/2019/7959615.

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Background. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs. However, little information is available about sequelae following DIHS/DRESS resolution from an endocrinologist’s perspective. This study aimed to investigate the endocrine sequelae following DIHS/DRESS, from clinical feature to etiology. Methods. We retrospectively analyzed the patients diagnosed with DIHS/DRESS in Peking Union Medical College Hospital (PUMCH) during the period of 1 January 2012 to 31 December 2017, and th

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22

Steiner, N., A. Soares, R. Regla, M. Jr, and A. Pupulin. "Effect of Homeopathic Drug on Metabolic Abnormalities Induced by HAART in Mice." Asian Journal of Research in Medical and Pharmaceutical Sciences 2, no. 3 (2018): 1–9. http://dx.doi.org/10.9734/ajrimps/2017/38024.

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23

Eckhardt, Lee L., Sridharan Rajamani, and Craig T. January. "Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome." British Journal of Pharmacology 145, no. 1 (2005): 3–4. http://dx.doi.org/10.1038/sj.bjp.0706143.

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24

Sadamori, Naoki, Takeo Honda, and Fumi Toriyama. "Chromosome Abnormalities in Skin Fibroblasts Probably Induced by an Anti-cancer Drug." Journal of Dermatology 17, no. 3 (1990): 155–58. http://dx.doi.org/10.1111/j.1346-8138.1990.tb01617.x.

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25

Balaban, Jagoda, and Đuka Ninković-Baroš. "Lamotrigine Associated DRESS Syndrome – a Case Report." Serbian Journal of Dermatology and Venereology 7, no. 1 (2015): 23–33. http://dx.doi.org/10.1515/sjdv-2015-0003.

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AbstractDrug-induced delayed multiorgan hypersensitivity syndrome, also known as drug rash (reaction) with eosinophilia and systemic symptoms (DRESS) syndrome, represents a drug-induced cluster of skin, hematologic and systemic symptoms. More than forty drugs have been associated with this syndrome. We present a case of DRESS syndrome suspecting that lamotrigine was directly responsible for the patient’s rash and other symptoms. A female patient presented with extensive skin rash, fever, hematologic abnormalities, organ involvement such as hepatitis, pancreatitis and respiratory symptoms. The

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26

Ogunsakin, Oluwaseun, Terence Tumenta, Scarlet Louis-Jean, et al. "Levetiracetam Induced Behavioral Abnormalities in a Patient with Seizure Disorder: A Diagnostic Challenge." Case Reports in Psychiatry 2020 (August 18, 2020): 1–4. http://dx.doi.org/10.1155/2020/8883802.

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Levetiracetam is a second-generation antiepileptic drug that is chemically unrelated to other antiepileptic drugs. Levetiracetam is a broad-spectrum antiseizure medication that is approved as an adjunctive therapy in the treatment of partial and generalized tonic-clonic seizures in children and adults with epilepsy. The mechanism by which Levetiracetam induces behavioral changes remains unknown. Its proposed mechanism of action involves binding to synaptic vesicle protein 2A (SV2A) and this leads to neuronal inhibition. Though, the drug has a convenient dosing regimen and is relatively well to

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Wilke, Russell A. "Potential Use of Pharmacogenetics to Reduce Drug-Induced Syndrome of Inappropriate Antidiuretic Hormone (SIADH)." Journal of Personalized Medicine 11, no. 9 (2021): 853. http://dx.doi.org/10.3390/jpm11090853.

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Syndrome of inappropriate antidiuretic hormone (SIADH) is a common cause of hyponatremia, and many cases represent adverse reactions to drugs that alter ion channel conductance within the peptidergic nerve terminals of the posterior pituitary. The frequency of drug-induced SIADH increases with age; as many as 20% of patients residing in nursing homes have serum sodium levels below 135 mEq/L. Mild hyponatremia is associated with cognitive changes, gait instability, and falls. Severe hyponatremia is associated with cerebral edema, seizures, permanent disability, and/or death. Although pharmacoge

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Corrias, Alberto, Wayne Giles, and Blanca Rodriguez. "Ionic mechanisms of electrophysiological properties and repolarization abnormalities in rabbit Purkinje fibers." American Journal of Physiology-Heart and Circulatory Physiology 300, no. 5 (2011): H1806—H1813. http://dx.doi.org/10.1152/ajpheart.01170.2010.

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Purkinje cells play an important role in drug-induced arrhythmogenesis and are widely used in preclinical drug safety assessments. Repolarization abnormalities such as action potential (AP) prolongation and early afterdeploarizations (EAD) are often observed in vitro upon pharmacological interventions. However, because drugs do not act on only one defined target, it is often difficult to fully explain the mechanisms of action and their potential arrhythmogenicity. Computational models, when appropriately detailed and validated, can be used to gain mechanistic insights into the mechanisms of ac

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Mancano, Michael A. "Deferasirox-Induced Serious Metabolic Abnormalities; Bicalutamide-Induced Heart Failure; Combination Ipilimumab and Nivolumab–Induced Lethal Myocarditis; Polymyxin B-Trimethoprim Eye Drop–Induced Anaphylaxis; Methylphenidate-Induced Diffuse Maculopapular Rash." Hospital Pharmacy 52, no. 3 (2017): 172–76. http://dx.doi.org/10.1310/hpj5203-172.

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The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

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Ostroumova, O. D., M. S. Chernyaeva, A. I. Kochetkov, D. I. Bakhteeva, S. N. Ivanov, and D. A. Sychev. "Atrial Fibrillation Associated with Anticancer Drugs." Safety and Risk of Pharmacotherapy 8, no. 4 (2020): 178–90. http://dx.doi.org/10.30895/2312-7821-2020-8-4-178-190.

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Atrial fibrillation is a serious adverse reaction associated with the use of anticancer drugs. The aim of the study was to analyse scientific literature on the prevalence, pathophysiological mechanisms, and risk factors of anticancer drug-induced atrial fibrillation, ways of its prevention and treatment. The results of the study showed that the incidence of drug-induced atrial fibrillation varies depending on a specific anticancer drug and ranges from 1 to 86%. It is associated with the use of herbal anticancer agents, alkylating agents, protein kinase inhibitors, monoclonal antibodies, immuno

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Garcia-Perez, Elizabeth, Romà Solà, Mireia Sumalla, and Jordi Serra. "Behavioral and electrophysiological abnormalities in two rat models of antiretroviral drug-induced neuropathy." PAIN 156, no. 9 (2015): 1729–36. http://dx.doi.org/10.1097/j.pain.0000000000000205.

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32

Criado, Paulo Ricardo, Roberta Fachini Jardim Criado, João de Magalhães Avancini, and Claudia Giuli Santi. "Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) / Drug-induced Hypersensitivity Syndrome (DIHS): a review of current concepts." Anais Brasileiros de Dermatologia 87, no. 3 (2012): 435–49. http://dx.doi.org/10.1590/s0365-05962012000300013.

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The Drug Reaction with Eosinophilia and Systemic Symptoms syndrome, also known as Drug Induced Hypersensitivity Syndrome presents clinically as an extensive mucocutaneous rash, accompanied by fever, lymphadenopathy, hepatitis, hematologic abnormalities with eosinophilia and atypical lymphocytes, and may involve other organs with eosinophilic infiltration, causing damage to several systems, especially to the kidneys, heart, lungs, and pancreas. Recognition of this syndrome is of paramount importance, since the mortality rate is about 10% to 20%, and a specific therapy may be necessary. The path

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33

Natt, NK, S. Tarsem, Dr Anuba, S. Simarjeet, M. Sharma, and S. Harmanjit. "Phenytoin Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)." Journal of Nepal Paediatric Society 35, no. 1 (2015): 73–75. http://dx.doi.org/10.3126/jnps.v35i1.10539.

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Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse effect characterized by a skin rash with visceral involvement and haematological abnormalities. This adverse drug effect is often misdiagnosed and under-reported especially in paediatric age group due to its rarity and high occurrence of skin rash in various other viral illnesses of children. We report a case of DRESS in a three months old male child. A high index of suspicion, rapid diagnosis and prompt withdrawal can be life-saving for the patient.J Nepal Paediatr Soc 2015;35(1):73-75

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Blain, P. G., R. J. M. Lane, D. N. Bateman, and M. D. Rawlins. "Opiate-induced Rhabdomyolysis." Human Toxicology 4, no. 1 (1985): 71–74. http://dx.doi.org/10.1177/096032718500400109.

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Three patients with opiate self-poisoning developed acute muscle damage with elevated serum aspartate aminotransferase and creatine kinase activities, increased serum myoglobin concentrations, raised plasma creatinine concentrations, hypocalcaemia and hyperphosphataemia. These abnormalities gradually resolved over 7-10 days, but recovery was complicated due to the development of acute renal failure (requiring haemodialysis) in one patient. Plasma drug concentrations, shortly after admission, in the patients taking dihydrocodeine and morphine were grossly elevated (184 and 60 μg/l respectively)

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Damor, Rahul R., Amita R. Kubavat, and Kiran G. Piparva. "Drug reaction with eosinophilia and systemic symptom induced by carbamazepine: a case report." International Journal of Basic & Clinical Pharmacology 8, no. 5 (2019): 1115. http://dx.doi.org/10.18203/2319-2003.ijbcp20191610.

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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, potentially life-threatening acute adverse drug reaction (ADR), typically characterized by a long latency period (2-6 weeks to 3 months) from drug exposure. DRESS syndrome is defined by the presence of fever, cutaneous eruption, lymphadenopathy, systemic or asymptomatic internal organ involvement (e.g. Hepatitis, carditis, interstitial nephritis, interstitial pneumonitis, etc.) and haematological abnormalities, mainly leucocytosis, eosinophilia and sometimes atypical lymphocytosis. There are around 50 culprit d

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36

Seyedan, Atefehalsadat, Zahurin Mohamed, Mustafa Ahmed Alshagga, Sanaz Koosha, and Mohammed A. Alshawsh. "Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice." Journal of Ethnopharmacology 236 (May 2019): 173–82. http://dx.doi.org/10.1016/j.jep.2019.03.001.

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37

Pölönen, R. P., K. Penttinen, H. Swan, and K. Aalto-Setälä. "Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients." Stem Cells International 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/9109503.

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Mutations in the cardiac ryanodine receptor (RYR2) are the leading cause for catecholaminergic polymorphic ventricular tachycardia (CPVT). In this study, we evaluated antiarrhythmic efficacy of carvedilol and flecainide in CPVT patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carrying different mutations in RYR2. iPSC-CMs were generated from skin biopsies of CPVT patients carrying exon 3 deletion and L4115 or V4653F mutation in RYR2 and of a healthy individual. Ca2+ kinetics and drug effects were studied with Fluo-4 AM indicator. Carvedilol abolished Ca2+ abnorm

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Rebuzzini, Paola, Maurizio Zuccotti, Carlo A. Redi, and Silvia Garagna. "Chromosomal Abnormalities in Embryonic and Somatic Stem Cells." Cytogenetic and Genome Research 147, no. 1 (2015): 1–9. http://dx.doi.org/10.1159/000441645.

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The potential use of stem cells (SCs) for tissue engineering, regenerative medicine, disease modeling, toxicological studies, drug delivery, and as in vitro model for the study of basic developmental processes implies large-scale in vitro culture. Here, after a brief description of the main techniques used for karyotype analysis, we will give a detailed overview of the chromosome abnormalities described in pluripotent (embryonic and induced pluripotent SCs) and somatic SCs, and the possible causes of their origin during culture.

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Graff, Claus, Mads P. Andersen, Joel Q. Xue, et al. "Identifying Drug-Induced Repolarization Abnormalities from Distinct ECG Patterns in Congenital Long QT Syndrome." Drug Safety 32, no. 7 (2009): 599–611. http://dx.doi.org/10.2165/00002018-200932070-00006.

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40

Das, Dona, Dinesh E. Ragav, and A. Nasreen Begum. "Drug rash with eosinophilia and systemic symptoms, uncommon and commonly missed." International Journal of Advances in Medicine 6, no. 4 (2019): 1360. http://dx.doi.org/10.18203/2349-3933.ijam20193303.

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Drug Rash with eosinophilia and systemic symptoms, also called DRESS syndrome, is a rare form of drug induced hypersensitivity reaction that presents with skin eruptions, blood count abnormalities (eosinophilia) and internal organ involvement (lung, kidney, liver), making it life threatening at a rapid pace. The most commonly affected organ is liver, mimicking condition similar to acute hepatitis.

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Si, Xiaochen, R. Clinton Webb, and Joyce M. Richey. "Bezafibrate, an anti-hypertriglyceridemic drug, attenuates vascular hyperresponsiveness and elevated blood pressure in fructose-induced hypertensive rats." Canadian Journal of Physiology and Pharmacology 77, no. 10 (1999): 755–62. http://dx.doi.org/10.1139/y99-061.

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A high fructose diet induces hypertension, hyperinsulinemia - insulin resistance, and hypertriglyceridemia (syndrome X). In this study, we investigated the role of an abnormal lipid profile in mediating fructose-induced hypertension. We hypothesized that bezafibrate, a lipid-lowering drug, would reduce elevated blood pressure and inhibit increased vascular reactivity in fructose-fed rats. Male rats were placed on four different diets: group 1 was fed standard chow (n = 6); group 2 was fed 60% fructose (n = 5); group 3 was fed fructose plus bezafibrate (30 mg·kg-1·day-1; drinking water; n = 5);

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42

Naga Subrahmanyam, S., D. Tagoore Vijaya Lakshmi, G. V. Naga Raju, and G. V. Pavan Kumar. "Carbamazepine Induced Drug Rash with Eosinophilia and Systemic Symptoms." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 367–68. http://dx.doi.org/10.22270/jddt.v9i1-s.2330.

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Stabilizes inactivated state of sodium channels, thereby making neurons less excitable may reduce activity of nucleus ventralis of the thalamus or decrease synaptic transmission or summation of temporal stimulation leading to neuronal discharge.A adult of 68 years old patient came to dermatology department with chief complaints of neuralgia over scalp to relieve the symptoms physician prescribed carbamazepine 200mg Po OD. During his 2ndweek of treatment patient developed pain,fever,sore throat followed by skin rash.Better vigilance is necessary for implementation of safe and effective treatmen

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Watanabe, Hideaki. "Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms." Journal of Immunology Research 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/5163129.

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Drug-induced hypersensitivity syndrome (DIHS), also termed as drug reaction with eosinophilia and systemic symptoms (DRESS), is a multiorgan systemic reaction characterized by a close relationship with the reactivation of herpes virus. Published data has demonstrated that among patients with DIHS/DRESS, 75–95% have leukocytosis, 18.2–90% show atypical lymphocytes, 52–95% have eosinophilia, and 75–100% have hepatic abnormalities. Histologically, eosinophils were observed less frequently than we expected (20%). The mainstay of DIHS/DRESS treatment is a moderate dose of systemic corticosteroids,

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Nestler, Eric J. "Transcriptional mechanisms of addiction: role of ΔFosB". Philosophical Transactions of the Royal Society B: Biological Sciences 363, № 1507 (2008): 3245–55. http://dx.doi.org/10.1098/rstb.2008.0067.

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Regulation of gene expression is considered a plausible mechanism of drug addiction, given the stability of behavioural abnormalities that define an addicted state. Among many transcription factors known to influence the addiction process, one of the best characterized is ΔFosB, which is induced in the brain's reward regions by chronic exposure to virtually all drugs of abuse and mediates sensitized responses to drug exposure. Since ΔFosB is a highly stable protein, it represents a mechanism by which drugs produce lasting changes in gene expression long after the cessation of drug use. Studies

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Iliceto, Sabino, Carlo Caiati, Francesco Tota, and Paolo Rizzon. "The Importance of Stress-Induced Cardiac Wall Motion Abnormalities in the Evaluation of Drug Intervention." Drugs 43, Supplement 1 (1992): 33–36. http://dx.doi.org/10.2165/00003495-199200431-00008.

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Bhuiyan, Tanveer A., Claus Graff, Jørgen K. Kanters, et al. "A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities." Clinical Pharmacology & Therapeutics 103, no. 6 (2017): 1100–1106. http://dx.doi.org/10.1002/cpt.886.

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Oikawa, Shota, Hiroko Nomura, Miki Nishio, Rina Nagata, and Tadayoshi Hata. "Doxapram Hydrochloride Aggravates Adrenaline-Induced Arrhythmias Accompanied by Bidirectional Ventricular Tachycardia." ISRN Cardiology 2014 (January 9, 2014): 1–5. http://dx.doi.org/10.1155/2014/212045.

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Objectives. Doxapram hydrochloride is a respiratory stimulant that has an inhibitory effect on myocardial IK1 potassium channels and is thought to increase membrane instability and excitability in myocardial cells. We examined the arrhythmogenic effects of doxapram hydrochloride in a rat model of halothane adrenaline-induced arrhythmia. Methods. Thirteen female Wistar rats (12–14 weeks old) were used in the study. Animals were anesthetized with inhalation of halothane to permit observation of the effects of doxapram hydrochloride on halothane adrenaline-induced arrhythmia. Time-dependent chang

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Dutta, Pinaki, Girish Parthan, Anuradha Aggarwal, et al. "Amiodarone Induced Hyponatremia Masquerading as Syndrome of Inappropriate Antidiuretic Hormone Secretion by Anaplastic Carcinoma of Prostate." Case Reports in Urology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/136984.

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Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most common causes of hyponatremia. The usual causes are malignancies, central nervous system, pulmonary disorders, and drugs. Amiodarone is a broad spectrum antiarrhythmic agent widely used in the management of arrhythmias. The different side effects include thyroid dysfunction, visual disturbances, pulmonary infiltrates, ataxia, cardiac conduction abnormalities, drug interactions, corneal microdeposits, skin rashes, and gastrointestinal disturbances. SIADH is a rare but lethal side effect of amiodarone. We describ

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Bernabeu, Ignacio, Mónica Marazuela, Tomás Lucas, et al. "Pegvisomant-Induced Liver Injury Is Related to the UGT1A1*28 Polymorphism of Gilbert’s Syndrome." Journal of Clinical Endocrinology & Metabolism 95, no. 5 (2010): 2147–54. http://dx.doi.org/10.1210/jc.2009-2547.

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Abstract Context: Pegvisomant (PEG) therapy has been associated with drug-induced liver dysfunction in acromegalic patients. The mechanism of its toxicity remains unknown. Objective: The primary objective was to determine whether or not the UGT1A1*28 polymorphism associated with Gilbert’s syndrome influences the development of liver dysfunction during PEG treatment. Design and Setting: A cross-sectional study was conducted in four Spanish university hospitals. Patients: Thirty-six acromegalic patients with active disease, resistant to somatostatin analogs, participated. Results: The prevalence

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Balkrishna, Acharya, Yashika Rustagi, Kunal Bhattacharya, and Anurag Varshney. "Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras." Biomolecules 10, no. 4 (2020): 600. http://dx.doi.org/10.3390/biom10040600.

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Zebrafish is an elegant vertebrate employed to model the pathological etiologies of human maladies such as cardiac diseases. Persistent physiological stresses can induce abnormalities in heart functions such as cardiac hypertrophy (CH), which can lead to morbidity and mortality. In the present study, using zebrafish as a study model, efficacy of the traditional Indian Ayurveda medicine “Yogendra Ras” (YDR) was validated in ameliorating drug-induced cardiac hypertrophy. YDR was prepared using traditionally described methods and composed of nano- and micron-sized metal particles. Elemental compo

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