Academic literature on the topic 'Drug-Polymer conjugates'

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Journal articles on the topic "Drug-Polymer conjugates"

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Libánská, Alena, Eva Randárová, Franck Lager, Gilles Renault, Daniel Scherman, and Tomáš Etrych. "Polymer Nanomedicines with Ph-Sensitive Release of Dexamethasone for the Localized Treatment of Inflammation." Pharmaceutics 12, no. 8 (2020): 700. http://dx.doi.org/10.3390/pharmaceutics12080700.

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Polymer-drug conjugates have several advantages in controlled drug delivery to inflammation as they can accumulate and release the drug in inflamed tissues or cells, which could circumvent the shortcomings of current therapy. To improve the therapeutic potential of polymer-drug conjugates in joint inflammation, we synthesized polymer conjugates based on N-(2-hydroxypropyl) methacrylamide) copolymers labeled with a near-infrared fluorescent dye and covalently linked to the anti-inflammatory drug dexamethasone (DEX). The drug was bound to the polymer via a spacer enabling pH-sensitive drug relea
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Duncan, Ruth. "Drug-polymer conjugates." Anti-Cancer Drugs 3, no. 3 (1992): 175–210. http://dx.doi.org/10.1097/00001813-199206000-00001.

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Duncan, R. "Designing polymer conjugates as lysosomotropic nanomedicines." Biochemical Society Transactions 35, no. 1 (2007): 56–60. http://dx.doi.org/10.1042/bst0350056.

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Marriage of cell biology (the concept of ‘lysosomotropic drug delivery’) and the realization that water-soluble synthetic polymers might provide an ideal platform for targeted drug delivery led to the first synthetic polymer–drug conjugates that entered clinical trials as anticancer agents. Conceptually, polymer conjugates share many features with other macromolecular drugs, but they have the added advantage of the versatility of synthetic chemistry that allows tailoring of molecular mass and addition of biomimetic features. Conjugate characteristics must be optimized carefully to ensure that
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Ogira, Johnson O., P. O. Odumosu, and J. O. Onah. "Synthesis of Polymer Conjugates of Efavirenz, Tenofovir and Dolutegravir." Nigerian Journal of Pharmacy 59, no. 1 (2025): 252–63. https://doi.org/10.51412/psnnjp.2025.24.

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Background and purpose: Chitosan and alginate are examples of biodegradable polymers which have the advantage of controlled drug delivery, prevent overdose and toxicity. The aim of the study is to synthesize the three anti-retroviral drug-polymer conjugates of chitosan and alginate. Method: The synthetic pathways involved the synthesis of three different conjugates labelled as, A, B and C through a Schiff process reaction, Diazotization reaction and esterification reaction, respectively. After synthesis, the products were purified by recrystallisation and preparative TLC. The calibration curve
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Končič, Marijana, Branka Zorc та Predrag Novak. "Macromolecular prodrugs. XIII. Hydrosoluble conjugates of 17β-estradiol and estradiol-17β-valerate with polyaspartamide polymer". Acta Pharmaceutica 61, № 4 (2011): 465–72. http://dx.doi.org/10.2478/v10007-011-0039-x.

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Macromolecular prodrugs. XIII. Hydrosoluble conjugates of 17β-estradiol and estradiol-17β-valerate with polyaspartamide polymerTwo hydrosoluble conjugates of 17β-estradiol (ED) and estradiol-17β-valerate (EV) with polyaspartamide polymer were prepared and characterized. ED and EV were first chemically modified and bound to poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-aminoethyl-DL-aspartamide)] (PAHA), a hydrosoluble polyaspartamide-type copolymer bearing both hydroxyl and amino groups. ED was first converted to 17-hemisuccinate (EDS) and then bound to PAHA. In the resulting conju
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Kostková, H., L. Schindler, L. Kotrchová, et al. "Star Polymer-Drug Conjugates with pH-Controlled Drug Release and Carrier Degradation." Journal of Nanomaterials 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/8675435.

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In this study, we describe the design, synthesis, and physicochemical and preliminary biological characteristics of new biodegradable, high-molecular-weight (HMW) drug delivery systems with star-like architectures bearing the cytotoxic drug doxorubicin (DOX) attached by a hydrazone bond-containing spacer. The star polymers were synthesized by grafting semitelechelic N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers on a 2,2-bis(hydroxymethyl)propionic acid- (bis-MPA-) based polyester dendritic core. The molecular weight of the star polymers ranged from 280 to 450 000 g/mol and could be adju
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Elvira, C., A. Gallardo, J. Roman, and A. Cifuentes. "Covalent Polymer-Drug Conjugates." Molecules 10, no. 1 (2005): 114–25. http://dx.doi.org/10.3390/10010114.

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Kumar, Sahil, Alka Sharma, Rajesh K. Singh, DN Prasad, and TR Bhardwaj. "Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine." International Journal of Drug Delivery 9, no. 2 (2017): 36. http://dx.doi.org/10.5138/09750215.2133.

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<p class="Default"><span>The present study pertains to the delivery of antimalarial drug (Lumifantrine). In this, polyphosphazene has been used in the synthesis of polyphosphazene-linked conjugates of Lumifantrine. These polymer-linked Conjugates have been synthesized and characterized by modern analytical techniques. The <em>in-vitro</em> drug release of Lumifantrine drug conjugates: <em>p</em>-Amino benzoic acid ester substituted polyphosphazene drug conjugate <strong>(15)</strong> and Glycine methyl ester substituted polyphosphazene drug conju
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Grigoletto, Antonella, Gabriele Martinez, Daniela Gabbia, et al. "Folic Acid-Targeted Paclitaxel-Polymer Conjugates Exert Selective Cytotoxicity and Modulate Invasiveness of Colon Cancer Cells." Pharmaceutics 13, no. 7 (2021): 929. http://dx.doi.org/10.3390/pharmaceutics13070929.

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Although selective tumor delivery of anticancer drugs has been sought by exploiting either passive targeting or by ligand-mediated targeting, a selective anticancer therapy remains an unmet medical need. Despite the advances which have been achieved by nanomedicines, nanosystems such as polymer-drug conjugates still miss the goal of clinical efficacy. In this study, we demonstrated that polymer-drug conjugates require a thoroughly chemical design and the right targeting agent/polymer ratio to be selective and effective towards cancer cells. In particular, two PEG conjugates carrying paclitaxel
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Alayoubi, Oubadah, Yağmur Poyraz, Gana Hassan, et al. "Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials." Gels 11, no. 2 (2025): 96. https://doi.org/10.3390/gels11020096.

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Hybrid hydrogels from protein–polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein–polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein–polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein–polymer conjugations aim to create m
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Dissertations / Theses on the topic "Drug-Polymer conjugates"

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Devenish, Sean. "Studies of natural product derivatives: targeted polymer drug conjugates." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6661.

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Polymer drug conjugates are an emerging class of therapeutic agent that offer advantages in the treatment of cancer through long circulation times and passive targeting. A further benefit of using a polymeric framework is that it readily allows attachment of targeting motifs to enhance the drug specificity, as well as allowing variation of the drug component. In this work a series of targeted polymer drug conjugates were prepared that incorporated different drugs via peptide linkers designed to be stable in circulation but degradable at the target site. In order to ensure stability in circula
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Gilbert, Helena Rosalind Petra. "Bioresponsive polymer-protection conjugates as a unimolecular drug delivery system." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55685/.

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PEGylation has become very popular for the generation of nanomedicines with improved protein delivery properties, despite its lack of biodegradability. Researchers usually try to maximise retained protein activity during PEGylation. However, this proof of principle study aimed to create an inactive peptide or enzyme product, using a biodegradable polymer, that would elicit minimal activity/non-specific toxicity on administration. Following triggered site-specific degradation of the polymer, the hypothesis was that protein activity could be slowly regenerated in the general circulation or local
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Chau, Ying. "Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32332.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Includes bibliographical references.<br>We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and hepatic clearance, thereby improving the pharmacokinetics of the attached drugs. Traditionally, linkers are degraded by acidity or by some ubiquitous intracellular enzyme
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Sat, Nee Yee. "Factors that influence tumour targeting by the enhanced permeability and retention (EPR) effect." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325320.

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Mina, James. "Hyaluronic acid based polymer drug conjugates for the treatment of rheumatoid arthritis." Thesis, University of the West of Scotland, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.739391.

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Singh, Jennifer. "Polymer-drug conjugates based on hyaluronic acid for the treatment of rheumatoid arthritis." Thesis, University of the West of Scotland, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415937.

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The work represents an initial appraisal ofhow polymer-drug conjugates based upon hyaluronic acid (HA) may behave at sites of inflammation relative to unmodified HA. Three polymer drug conjugates were synthesized in which a model drug, p-nitroaniline (pNA) has been joined to HA via a peptide spacer group containing alanine (ala) and valine (val). The conjugates are: HA-ala-pNA, HA-val-ala-pNA, and HA-ala-ala-ala-pNA. Each of the conjugates was subjected to the degradative effects of both hyaluronidase and hydroxyl radicals by the Fenton reaction (generated by Fe2 + ions and H202) . Hyaluronida
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Jacobs, Jaco. "Poly(N-vinylpyrrolidone) - Poly(γ-benzyl-L-glutamate) conjugates". Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20369.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The combination of natural and synthetic polymers allow for the synthesis of advanced hybrid copolymers. These hybrid copolymers have applications in biomedical areas, one such area being in drug delivery systems (DDS). In this study, a modular approach was used to prepare amphiphilic block copolymers with the ability to self-assemble into three dimensional structures. Reversible addition-fragmentation chain transfer (RAFT) was the synthetic tool used to mediate the polymerization of N-vinylpyrrolidone. RAFT is a versatile
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Heinrich, Anne-Kathrin [Verfasser]. "Overcoming drug resistance by stimulus-sensitive drug delivery systems : a preclinical characterization of polymer-drug conjugates for the treatment of multi-drug resistant cancer / Anne-Kathrin Heinrich." Halle, 2017. http://d-nb.info/1144955262/34.

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Krishnan, Vinu. "Design and Synthesis of Nanoparticle “PAINT-BRUSH” Like Multi-Hydroxyl Capped Poly(Ethylene Glycol) Conjugates for Cancer Nanotherapy." Akron, OH : University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1217677351.

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Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2008.<br>"August, 2008." Title from electronic thesis title page (viewed 12/9/2009) Advisor, Stephanie T. Lopina; Committee members, Amy Milsted, Daniel B. Sheffer, Daniel Ely; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
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Park, Jongryul. "Poly(2-oxazoline) architectures for drug delivery systems." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/211439/1/Jongryul_Park_Thesis.pdf.

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The overall aim of my PhD research was to develop biocompatible materials, namely poly(2-oxazoline)s, in terms of chemical structures and chemical and physical properties for drug delivery systems. This thesis demonstrated novel strategies and unique approaches towards sophisticated drug delivery formulations. A combination of crosslinking chemistry, thermoresponsive properties, and drug conjugation was introduced to overcome common issues in typical drug delivery devices such as burst drug release and low drug efficiency. Ultimately, this thesis aimed to promote poly(2-oxazoline)s as the most
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Books on the topic "Drug-Polymer conjugates"

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Ronit, Satchi-Fainaro, and Duncan R, eds. Polymer therapeutics II: Polymers as drugs, conjugates, and gene delivery systems. Springer, 2006.

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Wang, Chun, and Youqing Shen. Polymer-Drug Conjugates. Springer London, Limited, 2020.

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Chopra, Neetu, Jitender Madan, Ashish Baldi, and Monika Chaudhary. Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications. Elsevier Science & Technology, 2023.

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Chopra, Neetu, Jitender Madan, Ashish Baldi, and Monika Chaudhary. Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications. Elsevier Science & Technology Books, 2023.

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(Editor), Ronit Satchi-Fainaro, and Ruth Duncan (Editor), eds. Polymer Therapeutics I: Polymers as Drugs, Conjugates and Gene Delivery Systems (Advances in Polymer Science). Springer, 2006.

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Duncan, Ruth, and Ronit Satchi-Fainaro. Polymer Therapeutics I: Polymers as Drugs, Conjugates and Gene Delivery Systems. Springer, 2010.

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Duncan, Ruth, and Ronit Satchi-Fainaro. Polymer Therapeutics II: Polymers as Drugs, Conjugates and Gene Delivery Sytems. Springer, 2010.

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(Editor), Ronit Satchi-Fainaro, and Ruth Duncan (Editor), eds. Polymer Therapeutics II: Polymers as Drugs, Conjugates and Gene Delivery Sytems (Advances in Polymer Science) (Advances in Polymer Science). Springer, 2006.

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Book chapters on the topic "Drug-Polymer conjugates"

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Fante, Cristina, and Francesca Greco. "Polymer-Drug Conjugates." In Engineering Polymer Systems for Improved Drug Delivery. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118747896.ch3.

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Fante, Cristina, María J. Vicent, and Francesca Greco. "Polymer-Drug Conjugates." In Fundamentals of Pharmaceutical Nanoscience. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-59478-6_6.

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Fante, Cristina, and Francesca Greco. "Polymer-Drug Conjugates." In Fundamentals of Pharmaceutical Nanoscience. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9164-4_7.

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Kopeček, Jindřich, and Pavla Kopečková. "Design of Polymer-Drug Conjugates." In Drug Delivery in Oncology. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634057.ch17.

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Duncan, Ruth. "Polymer-Drug Conjugates: Targeting Cancer." In Biomedical Aspects of Drug Targeting. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4757-4627-3_10.

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Mohanty, Anjan Kumar, Fahima Dilnawaz, Guru Prasad Mohanta, and Sanjeeb Kumar Sahoo. "Polymer–Drug Conjugates for Targeted Drug Delivery." In Advances in Delivery Science and Technology. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-11355-5_12.

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Singh, Sauraj, Ruchir Priyadarshi, Bijender Kumar, et al. "Polymer–Drug Conjugates as Drug Delivery Systems." In Applications of Encapsulation and Controlled Release. CRC Press, 2019. http://dx.doi.org/10.1201/9780429299520-4.

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Abu Ajaj, Khalid, and Felix Kratz. "Clinical Experience with Drug-Polymer Conjugates." In Drug Delivery in Oncology. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634057.ch26.

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Francis, Arul Prakash, and A. Jayakrishnan. "Chapter 11. Polymer–Drug Conjugates for Treating Local and Systemic Fungal Infections." In Biomaterials Science Series. Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781788012638-00303.

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Malviya, Rishabha, Arun Kumar Singh, and Sonali Sundram. "Opportunities and Difficulties for Anticancer Nanomedicines Based on Polymer–Drug Conjugates in Concurrent/Combination Treatment." In Emerging Roles of Nanocarrier in Cancer Therapy. CRC Press, 2024. http://dx.doi.org/10.1201/9781003451020-6.

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Conference papers on the topic "Drug-Polymer conjugates"

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Yurkovetskiy, Alex, Natalya Bodyak, Mao Yin, et al. "Abstract 4331: Advantages of polyacetal polymer-based antibody drug conjugates employing cysteine bioconjugation." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4331.

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Fang, Yang, and Xiaobo Tan. "Design and Modeling of a Petal-Shape, Conjugated Polymer-Actuated Micropump." In ASME 2008 Dynamic Systems and Control Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/dscc2008-2278.

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Conjugated polymers are emerging actuation materials for biomimetic robots and biomedical devices. Most previous research has been focused on the configurations of cantilever beams and linear extenders. However, the diaphragm configuration is needed in many potential applications, such as micro pumps for drug delivery and chemical/ biological analysis. In this paper the design of a conjugated polymer pumping diaphragm is investigated theoretically and experimentally. A petal-shape design is proposed to alleviate the edge constrains. Transfer function models from the actuation voltage to the di
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Lam, Robert, Xueqing Zhang, Mark Chen, and Dean Ho. "Functional Nanodiamond Internalization Mechanisms and Kinetics." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13339.

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Several reports have described the relationship between size, aspect ratio, surface modification and internalization for a variety of nanoparticles (i.e. gold, polymer, carbon nanotubes). Nanodiamonds (NDs) in particular have recently been implicated in a variety of biomedical applications. One of the most promising is in utilizing NDs as drug delivery carriers where successful internalization is of utmost importance. A few reports recently have demonstrated the energy dependent internalization of bare NDs. In this report, we investigate the internalization mechanism and kinetics of functional
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Thomas, Joshua, Alex Yurkovetskiy, Natalya Bodyak, et al. "Abstract C238: Polyacetal polymer-based anti-HER2 antibody-drug conjugate employing cysteine bioconjugation through thioether linkage allows a high drug loading of dolastatin-derived payload with excellent pharmacokinetics and potent anti-tumor activity." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-c238.

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Reports on the topic "Drug-Polymer conjugates"

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Nan, Anjan. Targetable Polymer-Antiangiogenic Drug Conjugates for Systemic Breast Cancer Therapy. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada462903.

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Li, Chun. Radiation-Induced Chemosensitization: Potentiation of Antitumor Activity of Polymer-Drug Conjugates. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada406209.

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Li, Chun. Radiation Induced Chemosensitization: Potentiation of Antitumor Activity of Polymer-Drug Conjugates. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada415707.

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