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Dissertations / Theses on the topic 'Drug-Polymer conjugates'

Author: Grafiati
Published: 25 May 2024
Last updated: 31 July 2025

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1

Devenish, Sean. "Studies of natural product derivatives: targeted polymer drug conjugates." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6661.

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Polymer drug conjugates are an emerging class of therapeutic agent that offer advantages in the treatment of cancer through long circulation times and passive targeting. A further benefit of using a polymeric framework is that it readily allows attachment of targeting motifs to enhance the drug specificity, as well as allowing variation of the drug component. In this work a series of targeted polymer drug conjugates were prepared that incorporated different drugs via peptide linkers designed to be stable in circulation but degradable at the target site. In order to ensure stability in circula
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2

Gilbert, Helena Rosalind Petra. "Bioresponsive polymer-protection conjugates as a unimolecular drug delivery system." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55685/.

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PEGylation has become very popular for the generation of nanomedicines with improved protein delivery properties, despite its lack of biodegradability. Researchers usually try to maximise retained protein activity during PEGylation. However, this proof of principle study aimed to create an inactive peptide or enzyme product, using a biodegradable polymer, that would elicit minimal activity/non-specific toxicity on administration. Following triggered site-specific degradation of the polymer, the hypothesis was that protein activity could be slowly regenerated in the general circulation or local
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3

Chau, Ying. "Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32332.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Includes bibliographical references.<br>We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and hepatic clearance, thereby improving the pharmacokinetics of the attached drugs. Traditionally, linkers are degraded by acidity or by some ubiquitous intracellular enzyme
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4

Sat, Nee Yee. "Factors that influence tumour targeting by the enhanced permeability and retention (EPR) effect." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325320.

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5

Mina, James. "Hyaluronic acid based polymer drug conjugates for the treatment of rheumatoid arthritis." Thesis, University of the West of Scotland, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.739391.

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6

Singh, Jennifer. "Polymer-drug conjugates based on hyaluronic acid for the treatment of rheumatoid arthritis." Thesis, University of the West of Scotland, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415937.

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The work represents an initial appraisal ofhow polymer-drug conjugates based upon hyaluronic acid (HA) may behave at sites of inflammation relative to unmodified HA. Three polymer drug conjugates were synthesized in which a model drug, p-nitroaniline (pNA) has been joined to HA via a peptide spacer group containing alanine (ala) and valine (val). The conjugates are: HA-ala-pNA, HA-val-ala-pNA, and HA-ala-ala-ala-pNA. Each of the conjugates was subjected to the degradative effects of both hyaluronidase and hydroxyl radicals by the Fenton reaction (generated by Fe2 + ions and H202) . Hyaluronida
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7

Jacobs, Jaco. "Poly(N-vinylpyrrolidone) - Poly(γ-benzyl-L-glutamate) conjugates". Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20369.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The combination of natural and synthetic polymers allow for the synthesis of advanced hybrid copolymers. These hybrid copolymers have applications in biomedical areas, one such area being in drug delivery systems (DDS). In this study, a modular approach was used to prepare amphiphilic block copolymers with the ability to self-assemble into three dimensional structures. Reversible addition-fragmentation chain transfer (RAFT) was the synthetic tool used to mediate the polymerization of N-vinylpyrrolidone. RAFT is a versatile
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8

Heinrich, Anne-Kathrin [Verfasser]. "Overcoming drug resistance by stimulus-sensitive drug delivery systems : a preclinical characterization of polymer-drug conjugates for the treatment of multi-drug resistant cancer / Anne-Kathrin Heinrich." Halle, 2017. http://d-nb.info/1144955262/34.

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9

Krishnan, Vinu. "Design and Synthesis of Nanoparticle “PAINT-BRUSH” Like Multi-Hydroxyl Capped Poly(Ethylene Glycol) Conjugates for Cancer Nanotherapy." Akron, OH : University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1217677351.

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Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2008.<br>"August, 2008." Title from electronic thesis title page (viewed 12/9/2009) Advisor, Stephanie T. Lopina; Committee members, Amy Milsted, Daniel B. Sheffer, Daniel Ely; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
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10

Park, Jongryul. "Poly(2-oxazoline) architectures for drug delivery systems." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/211439/1/Jongryul_Park_Thesis.pdf.

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The overall aim of my PhD research was to develop biocompatible materials, namely poly(2-oxazoline)s, in terms of chemical structures and chemical and physical properties for drug delivery systems. This thesis demonstrated novel strategies and unique approaches towards sophisticated drug delivery formulations. A combination of crosslinking chemistry, thermoresponsive properties, and drug conjugation was introduced to overcome common issues in typical drug delivery devices such as burst drug release and low drug efficiency. Ultimately, this thesis aimed to promote poly(2-oxazoline)s as the most
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11

Plà, Solans Helena. "Design, synthesis and biological evaluation of new polymer-drug conjugates based on polyglutamic acid and 5-Fluorouracil for the treatment of advanced colorectal cancer." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/284644.

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Although survival rates of colorectal cancer (CRC) treated with surgery and conventional chemotherapy are high, metastatic CRC still shows acute mortality rates. Current chemotherapeutic treatment involves high doses of cytotoxic drugs, particularly adjuvant combinations of 5-Fluorouracil (5-FU) and Irinotecan (prodrug of SN-38). However, these treatments cause undesirable effects to the patients, which can negatively contribute to their survival. The use of polymer-drug conjugates (PDC) has attracted great attention in the field of controlled drug delivery for cancer treatment, improving the
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12

Dellow, Jan L. "Methotrexate-polymer conjugates." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277516.

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13

Greenhalgh, Kerriann R. "Development of biocompatible multi-drug conjugated nanoparticles/smart polymer films for biomedicinal applications." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002318.

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14

Khanna, Kunal. "Synthesis and self-assembly of miktoarm polymers and design of a drug-polymer-imaging conjugate." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92397.

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15

Casanova, Marion. "Conception et évaluation de vecteurs polymériques d'iminium N-hétérocyclique à activité antiplasmodiale." Electronic Thesis or Diss., Aix-Marseille, 2023. http://theses.univ-amu.fr.lama.univ-amu.fr/230324_CASANOVA_795kpzkf736jdsb801go615hzgclu_TH.pdf.

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La vectorisation de médicaments a mis en exergue de réelles innovations pharmacologiques et pharmacocinétiques. Néanmoins, peu d’études originales ont été menées sur les vecteurs à visée antiparasitaire. Seuls des médicaments pour lesquels les parasites ont développé des mécanismes de résistance, ont été utilisés en vectorisation. Les conditions et coûts de préparation de ces nanoformulations sont également un frein majeur à leur future production. L’enjeu consistait donc à développer des nanovecteurs permettant la délivrance de nouvelles classes d’antiparasitaires, tout en s’appuyant sur une
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16

Jordan, Carolyn T. "DESIGN AND ANALYSIS OF CURCUMIN CONJUGATED POLY(BETA-AMINO ESTER) NETWORKS FOR CONTROLLED RELEASE IN OXIDATIVE STRESS ENVIRONMENTS." UKnowledge, 2018. https://uknowledge.uky.edu/cme_etds/84.

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Oxidative stress, the imbalance of free radical generation with antioxidant defenses, leads to cellular inflammation, apoptosis and cell death. This compromised environment results in debilitating diseases, such as oral mucositis (OM), atherosclerosis, and ischemia/reperfusion injury. Antioxidant therapeutics has been a proposed strategy to ameliorate these imbalances and maintain homeostatic environments. However, the success of these approaches, specifically curcumin, has been limited due to characteristics such as hydrophobicity and high reactivity when released as bolus doses to contest to
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17

Chung, Yen-Jo, and 鍾彥柔. "Antibody-polymer drug conjugate with controlled chain length." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/p5y824.

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碩士<br>國立中山大學<br>化學系研究所<br>107<br>Recently, biological medicine has gradually replaced the status of traditional chemical medicine in global pharmaceutical market. Among them, ADCs (Antibody-drug conjugate) has high site-specific for tumor cell and low systemic toxicity compared with traditional chemotherapy drugs, providing a new selection for future cancer treatment. In this research, we use our published boronic acid (BA)-tosyl initiator probe to have glycan-directed modification of IgG, and grow PEG from initiator site by Atom-transfer radical-polymerization (ATRP). After polymerization, we
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18

Lough, Emily Anne. "Exploration of a doxorubicin-polymer conjugate in lipid-polymer hybrid nanoparticle drug delivery." Thesis, 2017. https://hdl.handle.net/2144/23573.

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Nanoparticle (NP) drug delivery is a major focus in the research community because of its potential to use existing drugs in safer and more effective ways. Chemotherapy encapsulation in NPs shields the drug from the rest of the body while it is within the NP, with less systemic exposure leading to fewer off-target effects of the drug. However, passive loading of drugs into NPs is a suboptimal method, often leading to burst release upon administration. This work explores the impact of incorporating the drug-polymer conjugate doxorubicin-poly (lactic-co-glycolic) acid (Dox-PLGA) into a lipid-pol
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19

Johnson, Mark Trevor. "Synthesis of water soluble polymer-bound antiproliferative agents." Thesis, 2006. http://hdl.handle.net/10539/1511.

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Student Number : 9903022H MSc Dissertation School of Chemistry Faculty of Science<br>Cancer is characterised by the unconstrained growth of cancerous cells, which damages the healthy cells and ultimately the tissue of the host. Chemotherapy forms an essential component in the treatment of this disease, however most anti-tumour drugs suffer from various deficiencies, e.g. increased toxicity, reduced serum half life and poor water solubility. The focus of this project was to address some of these deficiencies by conjugating selected drugs to a water-soluble polymeric carrier. Selected w
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20

Yan, Liang. "Studies of self-assembled substituted poly(acrylate) networks as potential sustained drug delivery systems and of fluorescent conjugated polymer nanoparticles in cell imaging." Thesis, 2016. http://hdl.handle.net/2440/103611.

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Polymer networks are promising biomaterials for drug delivery as they have porous structures and are often biocompatible. The general aspects of the host-guest complexation capability of polymer networks containing cyclodextrins as well as their application in drug delivery are considered in Chapter 1. The introduction of cyclodextrins into polymer networks has the potential to improve drug loading capacity and modulate subsequent drug release behavior due to the host-guest complexation by cyclodextrins of drug molecules. Thus, Chapter 2 and Chapter 3 are concerned with new research on water s
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