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Journal articles on the topic 'Drug-Polymer conjugates'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Libánská, Alena, Eva Randárová, Franck Lager, Gilles Renault, Daniel Scherman, and Tomáš Etrych. "Polymer Nanomedicines with Ph-Sensitive Release of Dexamethasone for the Localized Treatment of Inflammation." Pharmaceutics 12, no. 8 (2020): 700. http://dx.doi.org/10.3390/pharmaceutics12080700.

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Polymer-drug conjugates have several advantages in controlled drug delivery to inflammation as they can accumulate and release the drug in inflamed tissues or cells, which could circumvent the shortcomings of current therapy. To improve the therapeutic potential of polymer-drug conjugates in joint inflammation, we synthesized polymer conjugates based on N-(2-hydroxypropyl) methacrylamide) copolymers labeled with a near-infrared fluorescent dye and covalently linked to the anti-inflammatory drug dexamethasone (DEX). The drug was bound to the polymer via a spacer enabling pH-sensitive drug relea

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2

Duncan, Ruth. "Drug-polymer conjugates." Anti-Cancer Drugs 3, no. 3 (1992): 175–210. http://dx.doi.org/10.1097/00001813-199206000-00001.

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3

Duncan, R. "Designing polymer conjugates as lysosomotropic nanomedicines." Biochemical Society Transactions 35, no. 1 (2007): 56–60. http://dx.doi.org/10.1042/bst0350056.

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Marriage of cell biology (the concept of ‘lysosomotropic drug delivery’) and the realization that water-soluble synthetic polymers might provide an ideal platform for targeted drug delivery led to the first synthetic polymer–drug conjugates that entered clinical trials as anticancer agents. Conceptually, polymer conjugates share many features with other macromolecular drugs, but they have the added advantage of the versatility of synthetic chemistry that allows tailoring of molecular mass and addition of biomimetic features. Conjugate characteristics must be optimized carefully to ensure that

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Ogira, Johnson O., P. O. Odumosu, and J. O. Onah. "Synthesis of Polymer Conjugates of Efavirenz, Tenofovir and Dolutegravir." Nigerian Journal of Pharmacy 59, no. 1 (2025): 252–63. https://doi.org/10.51412/psnnjp.2025.24.

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Background and purpose: Chitosan and alginate are examples of biodegradable polymers which have the advantage of controlled drug delivery, prevent overdose and toxicity. The aim of the study is to synthesize the three anti-retroviral drug-polymer conjugates of chitosan and alginate. Method: The synthetic pathways involved the synthesis of three different conjugates labelled as, A, B and C through a Schiff process reaction, Diazotization reaction and esterification reaction, respectively. After synthesis, the products were purified by recrystallisation and preparative TLC. The calibration curve

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Končič, Marijana, Branka Zorc та Predrag Novak. "Macromolecular prodrugs. XIII. Hydrosoluble conjugates of 17β-estradiol and estradiol-17β-valerate with polyaspartamide polymer". Acta Pharmaceutica 61, № 4 (2011): 465–72. http://dx.doi.org/10.2478/v10007-011-0039-x.

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Macromolecular prodrugs. XIII. Hydrosoluble conjugates of 17β-estradiol and estradiol-17β-valerate with polyaspartamide polymerTwo hydrosoluble conjugates of 17β-estradiol (ED) and estradiol-17β-valerate (EV) with polyaspartamide polymer were prepared and characterized. ED and EV were first chemically modified and bound to poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-aminoethyl-DL-aspartamide)] (PAHA), a hydrosoluble polyaspartamide-type copolymer bearing both hydroxyl and amino groups. ED was first converted to 17-hemisuccinate (EDS) and then bound to PAHA. In the resulting conju

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Kostková, H., L. Schindler, L. Kotrchová, et al. "Star Polymer-Drug Conjugates with pH-Controlled Drug Release and Carrier Degradation." Journal of Nanomaterials 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/8675435.

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In this study, we describe the design, synthesis, and physicochemical and preliminary biological characteristics of new biodegradable, high-molecular-weight (HMW) drug delivery systems with star-like architectures bearing the cytotoxic drug doxorubicin (DOX) attached by a hydrazone bond-containing spacer. The star polymers were synthesized by grafting semitelechelic N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers on a 2,2-bis(hydroxymethyl)propionic acid- (bis-MPA-) based polyester dendritic core. The molecular weight of the star polymers ranged from 280 to 450 000 g/mol and could be adju

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Elvira, C., A. Gallardo, J. Roman, and A. Cifuentes. "Covalent Polymer-Drug Conjugates." Molecules 10, no. 1 (2005): 114–25. http://dx.doi.org/10.3390/10010114.

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Kumar, Sahil, Alka Sharma, Rajesh K. Singh, DN Prasad, and TR Bhardwaj. "Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine." International Journal of Drug Delivery 9, no. 2 (2017): 36. http://dx.doi.org/10.5138/09750215.2133.

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<p class="Default"><span>The present study pertains to the delivery of antimalarial drug (Lumifantrine). In this, polyphosphazene has been used in the synthesis of polyphosphazene-linked conjugates of Lumifantrine. These polymer-linked Conjugates have been synthesized and characterized by modern analytical techniques. The <em>in-vitro</em> drug release of Lumifantrine drug conjugates: <em>p</em>-Amino benzoic acid ester substituted polyphosphazene drug conjugate <strong>(15)</strong> and Glycine methyl ester substituted polyphosphazene drug conju

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Grigoletto, Antonella, Gabriele Martinez, Daniela Gabbia, et al. "Folic Acid-Targeted Paclitaxel-Polymer Conjugates Exert Selective Cytotoxicity and Modulate Invasiveness of Colon Cancer Cells." Pharmaceutics 13, no. 7 (2021): 929. http://dx.doi.org/10.3390/pharmaceutics13070929.

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Although selective tumor delivery of anticancer drugs has been sought by exploiting either passive targeting or by ligand-mediated targeting, a selective anticancer therapy remains an unmet medical need. Despite the advances which have been achieved by nanomedicines, nanosystems such as polymer-drug conjugates still miss the goal of clinical efficacy. In this study, we demonstrated that polymer-drug conjugates require a thoroughly chemical design and the right targeting agent/polymer ratio to be selective and effective towards cancer cells. In particular, two PEG conjugates carrying paclitaxel

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Alayoubi, Oubadah, Yağmur Poyraz, Gana Hassan, et al. "Hydrogels from Protein–Polymer Conjugates: A Pathway to Next-Generation Biomaterials." Gels 11, no. 2 (2025): 96. https://doi.org/10.3390/gels11020096.

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Hybrid hydrogels from protein–polymer conjugates are biomaterials formed via the chemical bonding of a protein molecule with a polymer molecule. Protein–polymer conjugates offer a variety of biological properties by combining the mechanical strength of polymers and the bioactive functionality of proteins. These properties allow these conjugates to be used as biocompatible components in biomedical applications. Protein–polymer conjugation is a vital bioengineering strategy in many fields, such as drug delivery, tissue engineering, and cancer therapy. Protein–polymer conjugations aim to create m

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11

Böhmová, Eliška, Robert Pola, Michal Pechar, et al. "Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length." Pharmaceutics 12, no. 1 (2020): 59. http://dx.doi.org/10.3390/pharmaceutics12010059.

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Cell-penetrating peptides (CPPs) are commonly used substances enhancing the cellular uptake of various cargoes that do not easily cross the cellular membrane. CPPs can be either covalently bound directly to the cargo or they can be attached to a transporting system such as a polymer carrier together with the cargo. In this work, several CPP–polymer conjugates based on copolymers of N-(2-hydroxypropyl)methacrylamide (pHPMA) with HIV-1 Tat peptide (TAT), a minimal sequence of penetratin (PEN), IRS-tag (RYIRS), and PTD4 peptide, and the two short hydrophobic peptides VPMLK and PFVYLI were prepare

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Xu, Jiankun, Shanmeng Lin, Hao Hu, Qi Xing, and Jin Geng. "Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro." Polymers 14, no. 21 (2022): 4515. http://dx.doi.org/10.3390/polym14214515.

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Bufalin (buf) has poor solubility in aqueous solution, poor tumor targeting, and many non-specific toxic and side effects. The advantages of high-molecular-weight polymer conjugates are that they can improve the water solubility of buf, prolong plasma half-life, and reduce non-specific toxicity. A novel water-soluble polymer–drug conjugate with buf and fluorescein pendants was prepared by the combination of reversible addition-fragmentation transfer (RAFT) polymerization and click chemistry. Its anticancer performance and cellular uptake behavior against liver cancer were investigated in vitro

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Chis, Adriana Aurelia, Anca Maria Arseniu, Claudiu Morgovan, et al. "Biopolymeric Prodrug Systems as Potential Antineoplastic Therapy." Pharmaceutics 14, no. 9 (2022): 1773. http://dx.doi.org/10.3390/pharmaceutics14091773.

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Nowadays, cancer represents a major public health issue, a substantial economic issue, and a burden for society. Limited by numerous disadvantages, conventional chemotherapy is being replaced by new strategies targeting tumor cells. In this context, therapies based on biopolymer prodrug systems represent a promising alternative for improving the pharmacokinetic and pharmacologic properties of drugs and reducing their toxicity. The polymer-directed enzyme prodrug therapy is based on tumor cell targeting and release of the drug using polymer–drug and polymer–enzyme conjugates. In addition, curre

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Wadhwa, Saurabh, and Russell J. Mumper. "Polymer-Drug Conjugates for Anticancer Drug Delivery." Critical Reviews in Therapeutic Drug Carrier Systems 32, no. 3 (2015): 215–45. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.2015010174.

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15

Manandhar, Sajana, Erica Sjöholm, Johan Bobacka, Jessica M. Rosenholm, and Kuldeep K. Bansal. "Polymer-Drug Conjugates as Nanotheranostic Agents." Journal of Nanotheranostics 2, no. 1 (2021): 63–81. http://dx.doi.org/10.3390/jnt2010005.

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Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, per

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16

Heath, Felicity, Amy Newman, Chiara Clementi, et al. "A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion." Polymer Chemistry 7, no. 47 (2016): 7204–10. http://dx.doi.org/10.1039/c6py01418f.

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A PEG–haloperidol conjugate was synthesised, which retains binding to the dopamine D<sub>2</sub>receptor, showing the possibility of using polymer-drug conjugates as drugsper se' rather than as prodrugs.

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17

Nicosia, Angelo, Giuseppe La Perna, Lorena Maria Cucci, Cristina Satriano, and Placido Mineo. "A Multifunctional Conjugated Polymer Developed as an Efficient System for Differentiation of SH-SY5Y Tumour Cells." Polymers 14, no. 20 (2022): 4329. http://dx.doi.org/10.3390/polym14204329.

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Polymer-based systems have been demonstrated in novel therapeutic and diagnostic (theranostic) treatments for cancer and other diseases. Polymers provide a useful scaffold to develop multifunctional nanosystems that combine various beneficial properties such as drug delivery, bioavailability, and photosensitivity. For example, to provide passive tumour targeting of small drug molecules, polymers have been used to modify and functionalise the surface of water-insoluble drugs. This approach also allows the reduction of adverse side effects, such as retinoids. However, multifunctional polymer con

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18

Sharma, Rajiv, Nishu Singla, Sahil Mehta, et al. "Recent Advances in Polymer Drug Conjugates." Mini-Reviews in Medicinal Chemistry 15, no. 9 (2015): 751–61. http://dx.doi.org/10.2174/1389557515666150519104507.

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19

Minko, Tamara. "Soluble polymer conjugates for drug delivery." Drug Discovery Today: Technologies 2, no. 1 (2005): 15–20. http://dx.doi.org/10.1016/j.ddtec.2005.05.005.

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20

Pitt, Colin G., Jason Wertheim, C. T. Wang, and Subodh S. Shah. "Polymer-drug conjugates: Manipulation of drug delivery kinetics." Macromolecular Symposia 123, no. 1 (1997): 225–34. http://dx.doi.org/10.1002/masy.19971230122.

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21

Šubr, Vladimír, Robert Pola, Shanghui Gao, et al. "Tumor Stimulus-Responsive Biodegradable Diblock Copolymer Conjugates as Efficient Anti-Cancer Nanomedicines." Journal of Personalized Medicine 12, no. 5 (2022): 698. http://dx.doi.org/10.3390/jpm12050698.

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Biodegradable nanomedicines are widely studied as candidates for the effective treatment of various cancerous diseases. Here, we present the design, synthesis and evaluation of biodegradable polymer-based nanomedicines tailored for tumor-associated stimuli-sensitive drug release and polymer system degradation. Diblock polymer systems were developed, which enabled the release of the carrier drug, pirarubicin, via a pH-sensitive spacer allowing for the restoration of the drug cytotoxicity solely in the tumor tissue. Moreover, the tailored design enables the matrix-metalloproteinases- or reductio

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22

Chrószcz-Porębska, Marta, and Agnieszka Gadomska-Gajadhur. "Cysteine Conjugation: An Approach to Obtain Polymers with Enhanced Muco- and Tissue Adhesion." International Journal of Molecular Sciences 25, no. 22 (2024): 12177. http://dx.doi.org/10.3390/ijms252212177.

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The modification of polymers towards increasing their biocompatibility gathers the attention of scientists worldwide. Several strategies are used in this field, among which chemical post-polymerization modification has recently been the most explored. Particular attention revolves around polymer-L-cysteine (Cys) conjugates. Cys, a natural amino acid, contains reactive thiol, amine, and carboxyl moieties, allowing hydrogen bond formation and improved tissue adhesion when conjugated to polymers. Conjugation of Cys and its derivatives to polymers has been examined mostly for hyaluronic acid, chit

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23

Kaur, Loveleen, Ajay Kumar Thakur, Pradeep Kumar, and Inderbir Singh. "Synthesis and characterization of Chitosan-Catechol conjugates: Development and in vitro, in silico and in vivo evaluation of mucoadhesive pellets of lafutidine." Journal of Bioactive and Compatible Polymers 36, no. 2 (2021): 139–51. http://dx.doi.org/10.1177/0883911521997849.

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Present study was aimed to synthesize and characterize Chitosan-Catechol conjugates and to design and develop mucoadhesive pellets loaded with lafutidine. SEM images indicated the presence of fibrous structures responsible for enhanced mucoadhesive potential of Chitosan-Catechol conjugates. Thermodynamic stability and amorphous nature of conjugates was confirmed by DSC and XRD studies respectively. Rheological studies were used to evaluate polymer mucin interactions wherein strong interactions between Chitosan-Catechol conjugate and mucin was observed in comparison to pristine chitosan and muc

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24

Kaur, Harmeet, Sapna D. Desai, Virender Kumar, Pooja Rathi, and Jasbir Singh. "Heterocyclic Drug-polymer Conjugates for Cancer Targeted Drug Delivery." Anti-Cancer Agents in Medicinal Chemistry 16, no. 11 (2016): 1355–77. http://dx.doi.org/10.2174/1871520615666160504094044.

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25

Ulbrich, Karel, Jiří Strohalm, Vladimír Šubr, Dana Plocová, Ruth Duncan, and Blanka Říhová. "Polymeric conjugates of drugs and antibodies for site‐specific drug delivery." Macromolecular Symposia 103, no. 1 (1996): 177–92. http://dx.doi.org/10.1002/masy.19961030118.

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AbstractThe synthesis of targetable conjugates of doxorubicin bound to N‐(2‐hydroxypropyl)methacrylamide copolymers was investigated. Anti‐CD3 antibody against TCR/CD3 complex was used to target the conjugates to T‐cells. The effect of structure of the oligopeptide spacer between the drug and polymer as well as of the polymer modification with the antibody on the rate of drug release from the polymeric carrier system incubated in vitro with cathepsin B or with a mixture of intracellular enzymes (tritosomes) is discussed. The results of in vitro drug‐release experiments are correlated with the

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26

Senevirathne, Suchithra A., Katherine E. Washington, Michael C. Biewer, and Mihaela C. Stefan. "PEG based anti-cancer drug conjugated prodrug micelles for the delivery of anti-cancer agents." Journal of Materials Chemistry B 4, no. 3 (2016): 360–70. http://dx.doi.org/10.1039/c5tb02053k.

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Development of polymer prodrug conjugates has evolved recently in the nano-medicine field for cancer diagnosis and treatment. This review focuses on the development of different types of PEG based polymer drug conjugates used for the delivery of anti-cancer agents.

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27

Theodosis-Nobelos, Panagiotis, Despina Charalambous, Charalampos Triantis, and Maria Rikkou-Kalourkoti. "Drug Conjugates Using Different Dynamic Covalent Bonds and their Application in Cancer Therapy." Current Drug Delivery 17, no. 7 (2020): 542–57. http://dx.doi.org/10.2174/1567201817999200508092141.

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Polymer-drug conjugates are polymers with drug molecules chemically attached to polymer side chains through either a weak (degradable bond) or a dynamic covalent bond. These systems are known as pro-drugs in the inactive form when passing into the blood circulation system. When the prodrug reaches the target organ, tissue or cell, the drug is activated by cleavage of the bond between the drug and polymer, under certain conditions existing in the target organ. The advantages of polymer-drug conjugates compared to other controlled-release carriers and conventional pharmaceutical formulations are

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Kratz, Felix, Ulrich Beyer, and Mark Thomas Schutte. "Drug-Polymer Conjugates Containing Acid-Cleavable Bonds." Critical Reviews in Therapeutic Drug Carrier Systems 16, no. 3 (1999): 245–88. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v16.i3.10.

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29

Sanchis, Joaquin, Fabiana Canal, Rut Lucas, and María J. Vicent. "Polymer–drug conjugates for novel molecular targets." Nanomedicine 5, no. 6 (2010): 915–35. http://dx.doi.org/10.2217/nnm.10.71.

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30

Yokoyama, Masayuki, Glenn S. Kwon, Teruo Okano, Yasuhisa Sakurai, Takashi Seto, and Kazunori Kataoka. "Preparation of micelle-forming polymer-drug conjugates." Bioconjugate Chemistry 3, no. 4 (1992): 295–301. http://dx.doi.org/10.1021/bc00016a007.

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31

Girase, Monika Lotansing, Priyanka Ganeshrao Patil, and Pradum Pundlikrao Ige. "Polymer-drug conjugates as nanomedicine: a review." International Journal of Polymeric Materials and Polymeric Biomaterials 69, no. 15 (2019): 990–1014. http://dx.doi.org/10.1080/00914037.2019.1655745.

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32

Khandare, Jayant, and Tamara Minko. "Polymer–drug conjugates: Progress in polymeric prodrugs." Progress in Polymer Science 31, no. 4 (2006): 359–97. http://dx.doi.org/10.1016/j.progpolymsci.2005.09.004.

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33

Ke, S., L. Milas, C. Charnsangavej, S. Wallace, and C. Li. "Potentiation of radioresponse by polymer–drug conjugates." Journal of Controlled Release 74, no. 1-3 (2001): 237–42. http://dx.doi.org/10.1016/s0168-3659(01)00322-4.

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34

Krakovičová, Hana, Tomáš Etrych, and Karel Ulbrich. "HPMA-based polymer conjugates with drug combination." European Journal of Pharmaceutical Sciences 37, no. 3-4 (2009): 405–12. http://dx.doi.org/10.1016/j.ejps.2009.03.011.

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35

Canal, Fabiana, Joaquin Sanchis, and María J. Vicent. "Polymer–drug conjugates as nano-sized medicines." Current Opinion in Biotechnology 22, no. 6 (2011): 894–900. http://dx.doi.org/10.1016/j.copbio.2011.06.003.

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Duncan, R., and F. Spreafico. "Polymer-drug conjugates: Challenges for phase I." European Journal of Cancer 29 (January 1993): S35. http://dx.doi.org/10.1016/0959-8049(93)90787-g.

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Parveen, Shazia, Farukh Arjmand, and Sartaj Tabassum. "Clinical developments of antitumor polymer therapeutics." RSC Advances 9, no. 43 (2019): 24699–721. http://dx.doi.org/10.1039/c9ra04358f.

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Polymer therapeutics encompasses polymer–drug conjugates that are nano-sized, multicomponent constructs already in the clinic as antitumor compounds, either as single agents or in combination with other organic drug scaffolds.

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Duro-Castano, A., J. Movellan, and M. J. Vicent. "Smart branched polymer drug conjugates as nano-sized drug delivery systems." Biomaterials Science 3, no. 10 (2015): 1321–34. http://dx.doi.org/10.1039/c5bm00166h.

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Branched polymers own special properties derived from their intrinsic characteristics. These properties make them ideal candidates to be used as carriers for an improved generation of polymer-drug conjugates.

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Dutta, Sikhamoni, and Debapratim Das Gupta. "Conjugation of Ibuprofen to Poly Ethylene Glycol and In-vitro drug release evaluation." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 110–15. http://dx.doi.org/10.22270/jddt.v9i3-s.2953.

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Polymers have become an integral part of drug delivery systems due to their improved pharmacokinetics properties. Polymer conjugation is a well-known and widely exploited technique useful to improve therapeutic properties of peptides, proteins, small molecules and oligonucleotides. Polymer conjugated drug generally exhibit prolonged half-life, higher stability, water solubility, lower immunogenicity, antigenicity and often also to the specific targeting tissue. Polymer materials are designed to be capable of delivering active substance. to the target diseased tissues and cells. Conjugation of

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Kumbhani, Kerul, and Yadavendra Agrawal. "Drug Conjugated Nanomedicine as Prodrug Carrier." Nanoscience & Nanotechnology-Asia 11, no. 6 (2013): 86–84. http://dx.doi.org/10.2174/22106812112039990001.

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: It is new approach to combine one or multiple drugs onto the same drug-delivery nanocarrier in accurately controllable manner, by covalently preconjugating one or multiple therapeutic agents by covalent bond to form drug conjugates. It provides the advantages of nano size system with the targeted delivery of drug with great precision. The conjugation system allows the modification in the metabolic path way in the blood stream and can target the delivery to the heart, liver or brain. The cleavable covalent bond allows the therapeutic activity of the individual drugs to be resumed after the dr

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Deneka, Alexander Y., Yanis Boumber, Tim Beck, and Erica A. Golemis. "Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC)." Cancers 11, no. 9 (2019): 1297. http://dx.doi.org/10.3390/cancers11091297.

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There are few effective therapies for small cell lung cancer (SCLC), a highly aggressive disease representing 15% of total lung cancers. With median survival <2 years, SCLC is one of the most lethal cancers. At present, chemotherapies and radiation therapy are commonly used for SCLC management. Few protein-targeted therapies have shown efficacy in improving overall survival; immune checkpoint inhibitors (ICIs) are promising agents, but many SCLC tumors do not express ICI targets such as PD-L1. This article presents an alternative approach to the treatment of SCLC: the use of drug conjugates

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Yang, Qiang, Ruogu Qi, Jing Cai, et al. "Biodegradable polymer–platinum drug conjugates to overcome platinum drug resistance." RSC Advances 5, no. 101 (2015): 83343–49. http://dx.doi.org/10.1039/c5ra11297d.

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Marasini, Nirmal, Shadabul Haque, and Lisa M. Kaminskas. "Polymer-drug conjugates as inhalable drug delivery systems: A review." Current Opinion in Colloid & Interface Science 31 (September 2017): 18–29. http://dx.doi.org/10.1016/j.cocis.2017.06.003.

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Pethő, Lilla, György Kasza, Eszter Lajkó, et al. "Amphiphilic drug–peptide–polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: the effect of conjugate aggregation on in vitro activity." Soft Matter 16, no. 24 (2020): 5759–69. http://dx.doi.org/10.1039/d0sm00428f.

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EGFR targeting drug–polymer–peptide conjugates have enhanced solubility wherein in vitro biological activity highly depends on the structure of conjugates due to their amphiphilic character and self-aggregation properties.

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Park, Jong-Ryul, Mariah Sarwat, Eleonore C. L. Bolle, et al. "Drug–polymer conjugates with dynamic cloud point temperatures based on poly(2-oxazoline) copolymers." Polymer Chemistry 11, no. 32 (2020): 5191–99. http://dx.doi.org/10.1039/d0py00602e.

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Rahmat, Deni, Fikry A. R. Rahman, Liliek Nurhidayati, and Dian Ratih Laksmitawati. "SYNTHESIS AND CHARACTERIZATION OF HYDROXYPROPYL CELLULOSE-CYSTEAMINE CONJUGATE AS A NOVEL CATIONIC THIOMER WITH LIPOPHILIC PROPERTIES." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 222. http://dx.doi.org/10.22159/ijap.2019v11i1.30014.

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Objective: Thiomers have been known as polymer with mucoadhesive properties. The aim of this study was to synthesize the mucoadhesive potential of hydroxypropyl cellulose-cysteamine conjugate (HPC-cysteamine).Methods: The parent polymer HPC was chemically modified by introducing sulphydryl bearing compound using reductive amination. HPC-cysteamine conjugates were prepared at reaction pH value of 5. The reaction was stabilized by the addition of cyanoborohydride. Afterwards, the conjugate was evaluated for optimum free thiol group, swelling behavior, viscosity and mucoadhesive properties.Result

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Hreczuk-Hirst, Dale, Lisa German, and Ruth Duncan. "Dextrins as Carriers for Drug Targeting: Reproducible Succinoylation as a Means to Introduce Pendant Groups." Journal of Bioactive and Compatible Polymers 16, no. 5 (2001): 353–65. http://dx.doi.org/10.1106/qbky-e3vm-19k4-3ga5.

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Dextrin (a-1,4 polyglucose) is in clinical use as a peritoneal dialysis solution and controlled drug delivery formulation. As a biodegradable polymer, dextrin has considerable potential as a polymeric drug carrier. Succinoylation, using dimethylaminopyridine (DMAP) as a catalyst, was used to conjugate chemotherapeutic agents, probes to follow biodistribution and probes to monitor intracellular fate. The aims of this study were to optimize the reaction conditions for the succinoylation (in respect of temperature and reaction time), to assess the suitability of succinoylated-dextrin as an interm

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Tavares, Marina R., Klára Hrabánková, Rafał Konefał, et al. "HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy." Pharmaceutics 13, no. 2 (2021): 179. http://dx.doi.org/10.3390/pharmaceutics13020179.

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The study describes the synthesis, physicochemical properties, and biological evaluation of polymer therapeutics based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers intended for a tumor-targeted immuno-oncotherapy. Water-soluble linear and cholesterol-containing HPMA precursors were synthesized using controlled reversible addition–fragmentation chain transfer polymerization to reach molecular weight Mn about 2 × 104 g·mol−1 and low dispersity. These linear or self-assembled micellar conjugates, containing immunomodulatory agent cucurbitacin-D (CuD) or the anticancer drug doxorubicin (

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Kumar, Ganesh, Ujjwal Nautiyal, Meenakshi Bhatt, and Archana Dhyani. "Development and Characterization of Gold Nanoparticles Conjugates to Increase Bioavailability of 6-Gingerol." Journal of Pharmaceutical Research International 36, no. 5 (2024): 12–24. http://dx.doi.org/10.9734/jpri/2024/v36i57513.

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6-Gingerol, an abundant component of Zingiber officinale, acts as a cardiotonic and is also used in the treatment of cancer disease, but its low solubility makes it very challenging in therapeutic applications. As we are all aware of the metal toxicity of nanoparticles, here we are using gold metal because gold nanoparticles are found to have lower toxicity than other metals. In this study, we prepared optimized conjugated gold nanoparticles of 6-Gingerol (Au-6G-PVP-NPs) by chemical reduction method using polyvinylpyrrolidone, a biocompatible and biodegradable polymer, to increase the bioavail

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Yin, Tingjie, Jing Wang, Lifang Yin, Linjia Shen, Jianping Zhou, and Meirong Huo. "Redox-sensitive hyaluronic acid–paclitaxel conjugate micelles with high physical drug loading for efficient tumor therapy." Polymer Chemistry 6, no. 46 (2015): 8047–59. http://dx.doi.org/10.1039/c5py01355k.

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Characterization of targeted redox-sensitive micelles self-assembled from polymer–drug conjugates exhibiting conspicuous drug loading capabilities, selective cellular uptake, rapid intracellular disassembly and drug release is presented.

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