Journal articles: 'Drug related problems (DRPs)'

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Nguyen, Thao H., Vy T. T. Le, Dung N. Quach, Han G. Diep, Nguyet K. Nguyen, Anh N. Lam, Suol T. Pham, Katja Taxis, Thang Nguyen, and Phuong M. Nguyen. "Drug-Related Problems in Prescribing for Pediatric Outpatients in Vietnam." Healthcare 9, no. 3 (March 14, 2021): 327. http://dx.doi.org/10.3390/healthcare9030327.

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Background: Our study was conducted to determine the prevalence of drug-related problems (DRPs) in outpatient prescriptions, the impact of DRPs on treatment efficacy, safety, and cost, and the determinants of DRPs in prescribing for pediatric outpatients in Vietnam. Methods: A retrospective cross-sectional study was conducted on pediatric outpatients at a pediatric hospital in Can Tho, Vietnam. DRPs were classified according to the Pharmaceutical Care Network Europe classification (PCNE) of 2020. The study determined prevalence of DRPs and their impacts on efficacy, safety, and cost. Multivariate regression was used to identify the determinants of DRPs. Results: The study included 4339 patients (mean age 4.3, 55.8% male), with a total of 3994 DRPs, averaging 0.92 DRP/prescription. The proportion of prescriptions with at least one DRP was 65.7%. DRPs included inappropriate drug selection (35.6%), wrong time of dosing relative to meals (35.6%), inappropriate dosage form (9.3%), inappropriate indication (7.1%), and drug-drug interactions (0.3%). The consensus of experts was average when evaluating each aspect of efficiency reduction, safety reduction, and treatment cost increase, with Fleiss’ coefficients of 0.558, 0.511, and 0.541, respectively (p < 0.001). Regarding prescriptions, 50.1% were assessed as reducing safety. The figures for increased costs and decreased treatment effectiveness were 29.0% and 23.9%, respectively. Patients who were ≤2 years old were more likely to have DRPs than patients aged 2 to 6 years old (OR = 0.696; 95% CI = 0.599–0.809) and patients aged over 6 years old (OR = 0.801; 95% CI = 0.672–0.955). Patients who had respiratory system disease were more likely to have DRPs than patients suffering from other diseases (OR = 0.715; 95% CI = 0.607–0.843). Patients with comorbidities were less likely to have DRPs than patients with no comorbidities (OR = 1.421; 95% CI = 1.219–1.655). Patients prescribed ≥5 drugs were more likely to have DRPs than patients who took fewer drugs (OR = 3.677; 95% CI = 2.907–4.650). Conclusion: The proportion of prescriptions in at least one DRP was quite high. Further studies should evaluate clinical significance and appropriate interventions, such as providing drug information and consulting doctors about DRPs.

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Repp, Kristin L., Charles Hayes, T. Mark Woods, Keith B. Allen, Kevin Kennedy, and Michael A. Borkon. "Drug-Related Problems and Hospital Admissions in Cardiac Transplant Recipients." Annals of Pharmacotherapy 46, no. 10 (October 2012): 1299–307. http://dx.doi.org/10.1345/aph.1r094.

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Background: Drug-related problems (DRPs) in the general population account for 15% of all hospital admissions, of which approximately 30% are preventable. Cardiac transplant patients may be at increased risk for DRPs because of their complicated medication regimens that include drugs with a narrow therapeutic index. Objective: To determine the incidence and praventability of DRPs causing hospital admission in cardiac transplant patients at a single institution. Methods: Between November 2009 and January 2010, a prospective longitudinal study investigated the incidence and preventability of DRPs in a single cardiac transplant center. Three independent reviewers used validated scoring systems to determine the incidence and preventability of drug-related hospital admissions. DRPs were classified by type, pharmacologic class, and impact on length of stay. Results: During the 3-month study period, 48 cardiac transplant patients were hospitalized. DRPs accounted for 40% (19/48) of these admissions and 58% (11/19) were adjudicated to be preventable. Common DRPs included supratherapeutic (32%) and subtherapeutic (16%) dosage, adverse drug reaction (32%), drug interaction (5%), and nonadherence (5%). Pharmacologic classes implicated included immunosuppressant (63%), antimicrobial (11%), electrolyte/fluid (11%). and anticoagulant (5%). Average length of stay in drug-related compared to non-drug-related admissions was 11.4 versus 8.5 days (p = 0.458). When annualized, 44 hospitalizations or 500 hospital days may have been prevented. Conclusions: Hospital admissions following cardiac transplantation are often drug related (40%) and preventable (58%). Incorporating this insight into the multidisciplinary transplant team may improve outcomes, assist in meeting national quality mandates by the United Network for Organ Sharing and Centers for Medicare Services, and lead to new benchmarks for transplant centers.

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Meng, Long, Can Qu, Xia Qin, Huali Huang, Yongsheng Hu, Feng Qiu, and Shusen Sun. "Drug-Related Problems among Hospitalized Surgical Elderly Patients in China." BioMed Research International 2021 (February 15, 2021): 1–6. http://dx.doi.org/10.1155/2021/8830606.

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There is a lack of data on drug-related problems (DRPs) among elderly patients from surgical departments. The current study is aimed at identifying and categorizing types of DRPs and assessing the severities of the DRPs. Medication orders for hospitalized patients aged ≥65 years from six surgery departments were reviewed to determine DRPs over 6 months in a tertiary teaching hospital of Chongqing, China. DRPs were classified based on the Pharmaceutical Care Network Europe classification V8.02. The severity ratings of the DRPs were assessed using the National Coordinating Council for Medication Error Reporting and Prevention classification. A total of 53,231 medication orders from 1,707 elderly patients were reviewed, and 1,061 DRPs were identified. Treatment safety (44.9%) was the most common DRP type. Drug selection (43.1%) and dose selection (43.1%) were the major causes of DRPs. A total of 75.1% of the DRPs were classified into severity categories B to D (causing no or potential harm), and 24.9% were classified as categories E to H (causing actual harm). DRPs are common in hospitalized elderly surgical patients. Pharmacists should provide medication order reviews in this vulnerable patient population.

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Ramadaniati, Hesty U., Yusi Anggriani, Vonny M. Wowor, and Alvina Rianti. "DRUG-RELATED PROBLEMS IN CHRONIC KIDNEYS DISEASE PATIENTS IN AN INDONESIAN HOSPITAL: DO THE PROBLEMS REALLY MATTER?" International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 12 (December 1, 2016): 298. http://dx.doi.org/10.22159/ijpps.2016v8i12.15193.

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Objective: To identify and evaluate drug-related problems (DRPs) in patients with chronic kidney disease (CKD).Methods: A prospective observational three-month study was conducted in adult patients with CKD hospitalized in five general medical wards and one intensive cardiac care unit in a major teaching hospital in Indonesia. Principal researcher (pharmacist) identified the occurrence of DRPs through the direct patient interview, discussion with nurses and assessment of patients’ medication charts and medical records. The identified DRPs were validated by a senior pharmacist and classified using Pharmaceutical Care Network Europe/PCNE classification scheme for DRP V6.2. Descriptive analysis was applied for demographic data, drug utilization and DRP profiles.Results: There were 105 patients who met the inclusion criteria and 80% of these patients had end-stage renal disease. A total of 2404 medication orders were reviewed and 1026 DRPs were identified. Potential DRPs accounted for around two-thirds of the cases. The rate of overall DRPs was 42.7 DRPs per 100 medication orders and each patient in the study experienced approximately ten DRPs during their hospitalization. Treatment effectiveness and adverse reaction domains contributed to the majority of DRPs primary domains for problems. Drugs for cardiovascular diseases and drugs for correcting electrolyte imbalance were most commonly implicated in DRP incidence.Conclusion: This study uncovered higher rate of DRPs experienced by each patient compared to other CKD studies. There were variations of DRP types when comparing with similar studies. Pharmacists’ competencies to identify, prevent and resolve DRPs are vital measures to improve clinical outcomes in CKD patients.

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Kibsdal, Karina Porsborg, Sabina Andersen, Parisa Gazerani, and Hanne Plet. "Rates and correlates of pharmacotherapy-related problems among psychiatric inpatients: a representative Danish study." Therapeutic Advances in Psychopharmacology 10 (January 2020): 204512532095712. http://dx.doi.org/10.1177/2045125320957120.

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Background: Drug related problems (DRPs) occur frequently among psychiatric patients due to common prescribing errors and complex treatment schedules. Clinical pharmacists (CPs) are thought to play an important role in preventing DRPs and, consequently, to increasing the quality of inpatient care. There is, however, limited information available on DRPs within the psychiatric field in Denmark. The aim of this study was to identify rates and correlates of pharmacotherapy-related problems among psychiatric inpatients in a Danish psychiatric hospital. Methods: A retrospective descriptive study was conducted by two CPs and data were obtained from the medical records available in two psychiatric wards. Chart-reviews were conducted for the period of June 2015 to February 2017. The analyses focussed on the prevalence of DRP categories, implementation and acceptance rates, and drugs associated with the DRPs. Extracted data were discussed with the wards’ physicians and registered in a DRP-database. Results: In total, 607 medical records were reviewed and, on average, 2.5 DRPs per medication review were found. There was a positive correlation between the number prescribed drugs and the average number of DRPs. The most frequent categories of DRPs were ‘drug dosage’, ‘inappropriate drug’ and ‘interactions’. The drugs represented most frequently in DRPs were olanzapine, quetiapine and pantoprazole. The overall acceptance rate was 49% with 33% of those implemented clinically. Conclusion: DRPs were commonly observed among psychiatric patients, particularly in those with multiple prescriptions, in relation to drugs dosage, inappropriate prescriptions and drug interactions. Particular attention must be paid to olanzapine, quetiapine and pantoprazole. Strategies to minimise DRPs among psychiatric patients are warranted and CPs can play an important role.

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TV, Niveditha, Abhishek Pradhan, and A. R. Shabaraya. "Drug Related Problems in Geriatric Patients with Inappropriate Medication Use." International Journal of Research and Review 8, no. 5 (June 3, 2021): 487–96. http://dx.doi.org/10.52403/ijrr.20210559.

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Drug related problem (DRP) is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Nowadays geriatric patients are at high risk of DRPs due to polypharmacy and altered physiology or due to older patients cannot manage their medication. DRPs also could arise from age related chronic diseases. The DRPs following hospital discharged cases also increased in elder people with chronic disease. Geriatric patients faces DRPs include inappropriate use of medication, polypharmacy, noncompliance, ADRs, drug–drug interaction, etc. Geriatric patients require more care because DRPs sometimes leads to hospital admission days, cost of the medication, increased morbidity rate and reduce the quality of life etc. So these category people need special consideration while selecting the drug therapy and its pattern. Like other health care services this special category of patients’ needs good care or services from a team of health care professionals including clinical pharmacists. This review article aims to understand the risk factors and different types of DRPs that are facing by the elderly people due to inappropriate medication use and pharmaceutical care by clinical pharmacists. Keywords: Geriatric patients, Polypharmacy, Non-compliance, and Drug related problems.

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Wucherer, D., J. R. Thyrian, T. Eichler, J. Hertel, I. Kilimann, S. Richter, B. Michalowsky, et al. "Drug-related problems in community-dwelling primary care patients screened positive for dementia." International Psychogeriatrics 29, no. 11 (August 7, 2017): 1857–68. http://dx.doi.org/10.1017/s1041610217001442.

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ABSTRACTBackground:Older people have a higher risk of drug-related problems (DRPs). However, little is known about the prevalence of DRPs in community-dwelling people who screened positive for dementia. Our study aimed to determine (1) the prevalence and types of DRPs and (2) the socio-demographic and clinical variables associated with DRPs in people screened positive for dementia in primary care.Methods:The Dementia: life- and person-centered help in Mecklenburg-Western Pomerania (DelpHi-MV) study is a general practitioner (GP)-based cluster-randomized controlled intervention study to implement and evaluate an innovative concept of collaborative dementia care management in the primary care setting in Germany. Medication reviews of 446 study participants were conducted by pharmacists based on a comprehensive baseline assessment that included a computer-based home medication assessment. ClinicalTrials.gov Identifier: NCT01401582.Results:A total of 1,077 DRPs were documented. In 414 study participants (93%), at least one DRP was detected by a pharmacist. The most frequent DRPs were administration and compliance problems (60%), drug interactions (17%), and problems with inappropriate drug choice (15%). The number of DRPs was significantly associated with the total number of drugs taken and with a formal diagnosis of a mental or behavioral disorder.Conclusions:Degree of cognitive impairment (MMSE defined) and formal diagnosis of dementia were not risk factors for an increased number of DRPs. However, the total number of drug taken and the presence of a diagnosis of mental and behavioral disorders were associated with an increased total number of DRPs.

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Haris kurniawan, Andi. "PHARMACIST INTERVENTION ON THE INCIDENCE OF DRUG RELATED PROBLEMS IN PATIEN WITH CHRONIC KIDNEY DISEASE IN RSU PKU MUHAMMADIYAH BANTUL." INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) 4, no. 2 (December 4, 2020): 1. http://dx.doi.org/10.21927/inpharnmed.v4i2.1253.

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<pre>Chronic kidney disease (CKD) is a disease that often appears in various countries. Progressive decline in kidney function in patients with chronic kidney disease can lead to unexpected events from drug use, due to decreased kidney function in excreting the drug and its metabolites in addition to the co-morbidities that often arise. Drug Related Problems (DRPs) is one of the problems that can arise from a treatment. Drug Related Problems (DRPs) in addition to impacting the effectiveness and safety of a treatment can also cause morbidity, mortality and treatment costs incurred by the patient. This study aims to look at the picture of DRPs that occur in CKD patients and the effect of pharmacist intervention on DRPs in PKU Muhammadiyah Hospital Bantul by comparing DRPs that arise before and after pharmacist intervention. This research is descriptive with an observational cohort design. Data was collected prospectively in a cohort to see DRPs drawings and the influence of pharmacist interventions on the incidence of DRPs in inpatient CKD patients at PKU Muhammadiyah Hospital in Bantul in the period August-October 2017. The DRPs category followed the PCNE V7.0 DRP classification, recorded DRPs in the problem category for 19 cases (45.2%) and the category of loading were 24 cases (57.1%). The most drug related problems were found to be non-optimal therapy (28.6%), the time / interval of drug administration (26.8%), the combination of drugs with drugs (16.7%) and there were indications of no drugs (11.9% ). Pharmacists intervened with the incidence of DRPs found, pharmacists intervened in the form of changing instructions for using drugs (30.7%), giving information / recommendations to prescribers (16.7%) and providing education to patients (11.9%). Pharmacist intervention can prevent or overcome the DRPs found. Conclusions in this study there are still DRPs that occur in inpatient CKD patients. The involvement of pharmacists can prevent or reduce the incidence of DRPs and ensure efficient, effective and safe drug therapy.</pre>

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Yismaw, Malede Berihun, Haileyesus Adam, and Ephrem Engidawork. "Identification and Resolution of Drug-Related Problems among Childhood Cancer Patients in Ethiopia." Journal of Oncology 2020 (March 16, 2020): 1–9. http://dx.doi.org/10.1155/2020/6785835.

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Background. Even though medications play a major role in the cure, palliation, and inhibition of disease, they also expose patients to drug-related problems. Drug-related problems are frequent and may result in reduced quality of life, morbidity, and mortality. Objectives. The study was aimed to identify, characterize, and resolve drug-related problems in the Pediatric Hematology/Oncology ward of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods. A prospective observational study was conducted from 25 June to 25 October 2018 to assess DRPs on patients admitted at the pediatric hematology/oncology ward of Tikur Anbessa Specialized Hospital, which is the highest level governmental tertiary care hospital in Ethiopia. Data were obtained from patients’ medical charts, physicians, patients/caregivers, pharmacists, and nurses. All the collected data were entered and analyzed using the Statistical Package for the Social Sciences version 25e. Descriptive statistics were used to represent the data. Results. Among the total 156 participants, DRPs were identified in 68.6% of the study subjects. Dosing problems which include dosage too low and high were the top ranking (39.3%) of all DRPs followed by needs additional therapy (27.2%) and nonadherence (14.0%). Systemic anti-infectives were the most common class of drugs involved in DRPs. Trimethoprim-sulfamethoxazole, methotrexate, vincristine, ondansetron, and metoclopramide were frequently involved in DRPs. The addition of drugs and change in drug dose were the two most proposed intervention types. Among the proposed interventions, 223 (92.15%) were fully accepted, 9 (3.72%) partially accepted, and 10 (4.13%) not accepted. Conclusion. DRPs are common among Pediatric Hematology/Oncology ward patients. The hospital should develop a pediatric dosing chart for the commonly prescribed medications to prevent drug-related morbidity and mortality. The integration of clinical pharmacists can mitigate risks associated with DRPs.

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Hale, Cory M., Jeffrey M. Steele, Robert W. Seabury, and Christopher D. Miller. "Characterization of Drug-Related Problems Occurring in Patients Receiving Outpatient Antimicrobial Therapy." Journal of Pharmacy Practice 30, no. 6 (January 23, 2017): 600–605. http://dx.doi.org/10.1177/0897190016688771.

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Background: Despite the numerous benefits of outpatient parenteral antimicrobial therapy (OPAT), appreciable risks of drug-related problems (DRPs) exist. No studies to date comprehensively assess DRPs in this population. Objectives: Objectives of this study were to (1) characterize the frequency and types of DRPs experienced by patients discharged on OPAT and (2) determine the fraction of adverse drug reactions (ADRs) resulting in hospital readmission or emergency department (ED) presentation and changes in therapy. Methods: This was a retrospective chart analysis evaluating consecutive adult patients discharged on OPAT between May 2015 and October 2015. Patients were assessed for the presence of DRPs until the cessation of antimicrobial treatment, including oral step-down therapy. The outcome of each ADR was recorded, including those resulting in hospital readmissions, presentation to the ED, or changes in antimicrobials. Results: Among 144 patients discharged on OPAT, 199 DRPs occurred in 91 (63.2%) patients. Harm and potential impaired efficacy occurred in 76.9% and 23.1%, respectively. The ADRs comprised 59% of DRPs, occurring in 44.4% of patients. The second most common DRP type was drug interactions (DIs), accounting for 22.6% of DRPs. Rifampin, fluoroquinolones, and daptomycin had the highest frequencies of preventable DRPs in the form of DIs, whereas cephalosporins had the fewest DRPs. Approximately 26% of ADRs caused changes in therapy and 9% resulted in hospital readmission or ED utilization. Conclusion: DRPs with the potential to cause patient harm or impair treatment efficacy often occur with OPAT, most commonly ADRs and DIs. Enhanced monitoring and transitions of care management may reduce the incidence of these DRPs.

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Astiti, Putu Maharani Ajeng, Alwiyah Mukaddas, and Safarudin Atho Illah. "Identifikasi Drug Related Problems (DRPs) Pada Pasien Pediatri Pneumonia Komunitas di Instalasi Rawat Inap RSD Madani Provinsi Sulawesi Tengah." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 3, no. 1 (March 1, 2017): 57–63. http://dx.doi.org/10.22487/j24428744.2017.v3.i1.8140.

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Drug Related Problems (DRPs) are events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes. DRPs may occur in the treatment of various diseases such as community acquired pneumonia (CAP). This study aims to determine the percentage of DRPs in pediatric inpatients with CAP. This is a descriptive and observational study design with prospective data conducted in November 2015 until February 2016 at Madani Hospital, Central Sulawesi. The results obtained from 28 patients showed that incidences of DRPs categories of inappropriate drug is 1 event (1,7%), inappropriate drug combination 35 events (58,3%), drugs dose too low 18 events (30%), drugs dose too high 6 events (10%), and no indication for drug 0 event (0%).

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Savitha R S, Madhan Ramesh, Manjunath S Shetty, and Kiran K K. "Drug-Related Problems and Pharmacist Interventions in Inpatients with Chronic Kidney Disease." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (January 31, 2020): 960–66. http://dx.doi.org/10.26452/ijrps.v11i1.1921.

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Studies report poor quality and break in the care of chronic kidney disease (CKD) patients due to complex pharmacotherapy, frequent dose changes and adherence issues. The addition of clinical pharmacists on the healthcare team will enable improved quality of care. The aim of the study is to characterize drug-related problems (DRPs) among CKD patients and intervene to improve patient outcomes. This prospective, interventional study was carried out in the admitted inpatients of a tertiary care hospital during the period October 2018 to May 2019. Patients admitted to inpatient wards of nephrology, medicine, surgery and orthopedics who was diagnosed with chronic kidney disease of any stage and etiology and who gave consent to participate were included in the study. Patients diagnosed with cancer and/or receiving chemotherapy, significant liver disease, as evidenced by Child-Pugh grades B and C, and those with substance abuse disorders were excluded from the study. A clinical pharmacist reviewed the patient treatment chart to identify drug-related problems and communicated appropriate suggestions or recommendations to the nephrologist or attending physician. Identified DRPs were categorized according to 'The Pharmaceutical Care Network Europe Foundation (PCNE) classification V 6.2. All DRPs and pharmacist interventions were documented appropriately. Among 833 patients included in the study, a total of 250 DRPs were identified from 245 patients. DRPs occurred at a rate of 1.02 per patient in the study population. The most common DRPs were adverse drug reactions (P2.1) (40.4%), followed by the effect of treatment not optimal (P1.2) (28%). The most common drug classes involved were antibiotics, tramadol, insulin, and oral antidiabetic drugs. Dose change and the new drug started were the most common interventions made. Pharmacists can make positive contribution in caring for patients with CKD.

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Wincent, Mannu Meria, D. Potrilingam, Anagha V., Sajith Chacko Jacob, and Andhuvan G. "ASSESSMENT OF DRUG RELATED PROBLEMS IN PATIENTS WITH CHRONIC DISEASES IN THE GENERAL MEDICINE UNITS OF A TERTIARY CARE HOSPITAL." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 12 (December 1, 2017): 194. http://dx.doi.org/10.22159/ijpps.2017v9i12.21660.

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Objective: Patients with chronic diseases are more prone to develop drug-related problems (DRPs), which can further worsen their quality of life. The aim of this study was to determine factors and medications associated with DRPs in patients with chronic disease.Methods: This prospective interventional study was conducted for a duration of 6 mo in the in-patients of general medicine department of PSG Hospital, Coimbatore. DRPs were identified, assessed and recorded as per pharmaceutical care network Europe (PCNE) V5.01 criteria. Chi-square and correlation test were used to analyze the data for identifying factors associated with DRPs.Results: A total of 137 patients were enrolled for the study, of which 66 patients developed DRPs. The most prevalent DRP was found to be drug choice problem. The major causes of DRPs were found to be drug and dose selection. Antidiabetic drugs were found to be more associated with drug-related problems. The incidence of drug-related problems was high in patients aged between 50 to 59 y. Association between gender, length of hospital stays and polypharmacy with DRPs was found to be statistically significant. 58.33% of the total drug-related problems were completely solved and 19.05% were partially solved.Conclusion: The incidence of DRPs in the General Medicine department of the hospital was high. The use of an appropriate tool such as PCNE may assist pharmacists and other healthcare professionals to systematically identify, categorize and report drug-related problems.

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Andayani, Tri Murti, Fita Rahmawati, and Rifky Rochman. "EVALUATION OF THE PHARMACY SUPPORT SYSTEM IN THE DETECTION OF DRUG-RELATED PROBLEMS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 14 (May 1, 2017): 90. http://dx.doi.org/10.22159/ajpcr.2017.v10s2.19497.

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Objective: The efficiency and speed of a system in identifying DRPs can support and optimize the performance of pharmacists. The objective of this research was to determine the time of analysis and the number of DRPs incidences identified by pharmacists with and without Pharmacy Support Systems (PSS).Methods: The present research was observational with cross-sectional design. The data collection was done prospectively in outpatients at hospital during January 2016. Observations were conducted to the difference between the analysis and the number of DRPs incidence identified by the pharmacists with and without the assistance of PSS. The research population was outpatient at a number of hospitals in Yogyakarta. The tools used in this research were PSS which were a clinical information system that can identify potential DRPs and included three main parts, namely the patients’ profile, drug information, and analysis of DRPs. The identification result of DRPs was consisted of six DRPs categories, i.e. without treatment indication, treatment without indication, ineffective drug, too low dose, too high dose, and undesirable drug reactions.Results: Pharmacists without PSS require faster time to analyze the prescription of outpatients. The time majority spent by pharmacists with PSS in reviewing the patients’ prescription lies in the length of time the patients enter the therapy-related data obtained manually by patients until the warning being displayed, and making clinical decision related to the DRPs. The statistical test result using Goodness of fit test and Fisher between categories of DRPs incidences detected by pharmacists with and without the assistance of PPS indicates significant differences (P <0.05). Pharmacists with PSS can detect DRPs that are not detected by the pharmacist without PSS. DRPs mostly identified by pharmacists with the assistance of PSS are drug interactions and improper doses. Improper doses primarily identified in geriatric and pediatric patients’ prescription.Conclusion: Pharmacists with PSS software can detect DRPs that are not detected by pharmacists only. But pharmacists using the software PSS requires a longer time in the identification of DRPs compared to pharmacists without using PSS.

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Monica, Cindy, Aminah S, and Siti Dalilla. "DRP EVALUASI DRUNG RELATED PROBLEMS (DRPs) ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP ANAK RUMAH SAKIT UMUM DAERAH DELI SERDANG." JURNAL FARMASIMED (JFM) 3, no. 2 (April 29, 2021): 63–68. http://dx.doi.org/10.35451/jfm.v3i2.574.

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Background: Infection is one of the top ten diseases in Indonesia, so that antibiotic therapy is quite high. The increasing use of antibiotics may lead to an increase in the use of irrational antibiotics. Drug Related Problems (DRPs) are events that are not expected from the patient's experience or are suspected to be due to drug therapy so that they have the potential to interfere with the desired healing success. Objective: This study aims to determine the number of occurrences of DRPs which include dosage inaccuracy, namely under and over dose, indication without drug, drug without indication, potential interactions and inaccuracy of drug selection in inpatient pneumonia treatment for children at the Deli Serdang Regional public hospital. In 2019 Method: This study is retrospective in which data is obtained through secondary data in the form of patient medical records for the period January-December 2019 with a cross-sectional study design. The data collection technique was in the form of total sampling, obtained 50 samples that fit the inclusion criteria. Results: Drung Related Problems (DRPs) research that occurred in the under-dose category of drugs (4.0%), and excessive drug doses (2.0%) and no DRPs (94.0%). This shows that the role of pharmacists is important in monitoring patient drug therapy to minimize the occurrence of DRPs.

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Faizah, Ana Khusnul, and Raswita Diniya. "A STUDY OF DRUG RELATED PROBLEM IN UROLOGIC PATIENTS: A COHORT PROSPECTIVE STUDY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 14 (May 1, 2017): 11. http://dx.doi.org/10.22159/ajpcr.2017.v10s2.19472.

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Objective:Drug therapy problems (DRPs) are the clinical domain of the pharmaceutical care practitioner. The purpose of identifying drug therapy problems is to help patients on achieving their goals of therapy and realizing the best possible outcomes from drug therapy. The purpose of this study was to determine the number of DRPs and to classifyDRPs that occurred in post-operative patients from urology surgery ward.Methods:A 3-month prospective study was conducted by considering62 hospitalized post-operative patients from urology surgery ward at the Teaching Hospital in Surabaya, East Java, Indonesia. Clinical pharmacists were involved in medical rounds to identify DRPs.Results:From 37 patients, 81 DRPs were identified in this study. About 20 patients were considered to have more than one DRP. The most common identified DRPs were over-dosage (38%), drug use without indication (20%),improper drug (11%), drug interaction (10%), untreated indication(9%), adverse drug reaction (7%), failure to receive drug (4%) and sub-therapeutic drugs (1%). The clinical pharmacists were involved in doing dose adjustment, monitoring, evaluating drug discontinuation, doing drug substitution and, additional therapy, counseling to patients, increasing dose and referring to prescriber.Conclusion:The most identified DRPs were over-dosage, drug use without indication and improper drug. Clinical pharmacist’s intervention were required toidentify, prevent, resolve DRPs and assist patient on achieving their goals of therapy and improving their quality of life.

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Timur, Willi Wahyu, Lukman Hakim, and Fita Rahmawati. "KAJIAN DRUG RELATED PROBLEMs PENGGUNAAN ANTIBIOTIK PADA PASIEN PEDIATRIK DI RSUD KOTA SEMARANG." Jurnal Farmasi Sains dan Praktis 3, no. 2 (December 17, 2017): 47–52. http://dx.doi.org/10.31603/pharmacy.v3i2.1744.

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Drug Related Problems (DRPs) merupakan masalah yang berhubungan dengan obat yang banyak terjadi di pelayanan kesehatan. Tujuan penelitian ini untuk mengetahui profil kejadian DRPs, profil antibiotik yang mengalami DRPs, dan hubungan antara Drug Related Problems penggunaan antibiotik dengan luaran terapi. Penelitian ini merupakan penelitian observasional analitik dengan rancangan retrospective cohort study. Subyek penelitian yang memenuhi kriteria inklusi sebanyak 128 pasien, dimana terdapat 78 kejadian drug related problems pada 64 pasien dengan rincian sebagai berikut; indikasi tanpa obat 0 kejadian, obat tanpa indikasi yang sesuai 5 kejadian (6,41%), pemberian obat tidak tepat 1 kejadian (1,28%), dosis kurang 17 kejadian (21,79%), dosis lebih 7 kejadian (8,97%), adverse drug reaction 14 kejadian (17,95%), interaksi obat 33 kejadian (42,32%), dan kegagalan menerima obat 1 kejadian (1,28%). Terdapat dua antibiotik yang paling banyak mengalami DRPs, yaitu ceftriaxon dan cefotaxim. Pada uji Chi square didapatkan tidak ada hubungan antara jumlah kejadian DRPs terhadap luaran terapi dan lama waktu rawat inap (p>0,05).

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Musdalipah, Musdalipah, Eny Nurhikma, and Sartika Sartika. "IDENTIFIKASI DRPs (DRUG RELATED PROBLEMs) PENDERITA ISPA PASIEN PEDIATRIK DI INSTALASI FARMASI RUMAH SAKIT." WARTA FARMASI 6, no. 1 (April 29, 2017): 37–49. http://dx.doi.org/10.46356/wfarmasi.v6i1.70.

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ABSTRAK Drug Related Problem (DRP) atau masalah terkait obat adalah bagian dari asuhan kefarmasian (parmaceutical care) yang menggambarkan suatu keadaan, dimana profesional kesehatan (apoteker) menilai adanya ketidaksesuaian pengobatan dalam mencapai terapi yang sesungguhnya. Tujuan penelitian adalah untuk mengidentifikasi DRPs penderita ISPA (Infeksi Saluran Pernafasan Akut) di Instalasi Farmasi Rumah Sakit kota Kendari dengan kategori polifarmasi, interaksi obat dan interval dosis. Penelitian ini menggunakan metode deskriptif dengan pendekatan Cross Sectional, sampel dalam penelitian ini adalah resep pasien pediatrik yang menderita ISPA. Pengambilan sampel menggunakan metode acak sederhana. Data diolah secara deskriptif dan di jabarkan dalam bentuk narasi. Hasil penelitian ini menunjukkan identifikasi DRPs (Drug Related Problems) dari 30 pasien penderita ISPA di temukan 11 (36,66%) pasien (43,33%) mengalami DRPs kategori polifarmasi, dan 4 pasien (13,33%) mengalami DRPs kategori interval dosis dan tidak di temukan DPRs kategori interaksi obat. Kata Kunci : DRPs, Peresepan, ISPA, Pediatrik ABSTRACT Drug Related Problem (DRP) is a part of pharmaceutical care that describes a situation in which the health professional (pharmacist) assesses a treatment discrepancy in achieving actual therapy. The purpose of this research was identification patient of ISPA (Acute Respiratory Infection) at Pharmacy Installation of Kendari Hospital with Polifarmacy category, drug interaction and dose interval. This research uses descriptive method with Cross Sectional approach, the sample in this research is recipe of pediatric patient suffering from ARI. Sampling using simple random method. Data is processed descriptively and described in the form of narration. The results of this study indicate that based on the identification of DRPs (Drug Related Problems) it can be concluded that from 30 patients with respiratory infection found 11 patients (36.66%) experienced DRPs polifarmation category, and 4 patients (13.33%) experienced DRPs category interval Dose and not found DPRs drug interaction category. Keywords : DRPs, Prescribing, ISPA, Child

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Kurniawati, Fivy, Nanang Munif Yasin, Farida Aulia, and Gidfrie Vinanda Krisha. "Drug-related problems of antibiotic use in gastroenteritis related to patient therapy outcomes at Universitas Gadjah Mada Hospital." Journal of Basic and Clinical Physiology and Pharmacology 32, no. 4 (June 25, 2021): 761–66. http://dx.doi.org/10.1515/jbcpp-2020-0451.

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Abstract Objectives Gastroenteritis is a disease of digestive system commonly occur among the people. Some cases of gastroenteritis are caused by bacteria, so it is treated by using antibiotics. Inappropriate use of antibiotics can be associated to Drug-Related Problems (DRPs). This study aims to identify patterns of potential DRPs of antibiotic use and analyze the effect of potential DRPs of antibiotic use toward the patient’s therapeutic outcomes and length of stay. Methods This is a retrospective cross-sectional study carried out by using patient’s medical record. The study population was gastroenteritis patients at the inpatient ward of Universitas Gadjah Mada Hospital during January 2018–June 2019. Then, SPSS was employed to analyze the data and the effect of potential DRPs toward therapeutic outcomes was analyzed by utilizing the chi-square method. Results More than half of gastroenteritis patients in Universitas Gadjah Mada Hospital were identified to have potential DRPs of antibiotic use. The most identified of potential DRPs was problems related to drug selection. Based on the chi-square analysis, there was no relationship between potential DRPs of antibiotic use and the therapeutic outcome. In addition, there was also no relationship between potential DRPs of antibiotic use and patient’s length of stay. Conclusions The potential DRPs of antibiotics use do not have a significant effect on the therapeutic outcome and length of stay of the gastroenteritis patients in Universitas Gadjah Mada Hospital.

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Astuti, Surya Yuli, Mawardi Ihsan, and Fita Rahmawati. "Hubungan antara Drug-Related Problems dan Lama Rawat Inap pada Pasien dengan Diabetes Tipe 2." JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) 10, no. 2 (June 30, 2020): 77. http://dx.doi.org/10.22146/jmpf.43576.

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Drug-Related Problems have been associated to blood glucose control along with the morbidity and mortality of type 2 diabetes patients through previous studies. However, studies that associate Length of Stay (LOS) with DRPs in type 2 diabetes patients have not been done. The study that had been done was to associate between LOS and Medication Errors (ME). Medication errors include DRPs because other researchers state that errors are also kind of problem. This study was aimed to identify Drug-Related Problems (DRPs) and to associate between DRPs and LOS in type 2 diabetes patients who were hospitalized. This study was a prospective observation study with a cross-sectional design. Sample collection was carried out by consecutive sampling method in type 2 diabetic patients hospitalized in internal medicine ward in one academic hospital in Yogyakarta. Data analysis was done descriptively to see DRPs description and the association between DRPs and LOS was analyzed using Chi-square or Fisher's exact test whenever Chi-square test conditions were not met. Data collection was carried out in January till April 2018. The results showed that the DRPs in hospitalized type 2 diabetic patients were 80.56% with unnecessary drug therapy occurring at 34.72%; dosage too low of 25%; needs additional drug therapy 13.38%; dosage too high 12.5%; ineffective drug 11.11%; and there was no association seen between DRPs and LOS.

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Maharani, Debby Dystra, Nadia Farhanah Syafhan, and Yetti Hersunaryati. "DRUG-RELATED PROBLEMS IN HOSPITALIZED GERIATRIC PATIENTS WITH DIABETES MELLITUS." International Journal of Applied Pharmaceutics 10, no. 1 (December 20, 2018): 142. http://dx.doi.org/10.22159/ijap.2018.v10s1.30.

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Objective: This study aimed at analyzing drug-related problems (DRPs) in hospitalized geriatric patients with diabetes mellitus.Methods: We prospectively collected data of 26 hospitalized geriatric patients at the Gatot Soebroto Army Hospital (age, >60 year) who underwentinpatient treatment for at least 1 month between February and April 2015. Readable data were obtained from prescriptions, medical records, andindex card/nurses records. We obtained data on 299 drug treatments for 26 patients and identified 166 DRPs. These were analyzed based on thePharmaceutical Care Network Europe Version 6.2.Results: The percentage of treatment effectiveness (50.6%) and adverse drug reactions (49.4%) was predominantly due to an inappropriate drug–drug or drug–food combination, including the incidence of drug interactions (20.4%).

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Rokiban, Akhmad, Dwiauliaramdini Dwiauliaramdini, and Sitijuwariyah Sitijuwariyah. "ANALISIS DRUG RELATED PROBLEMS (DRPs) PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 DI UPT PUSKESMAS RAWAT INAP GEDONG AIR BANDAR LAMPUNG." JFL: Jurnal Farmasi Lampung 9, no. 2 (March 13, 2021): 134–42. http://dx.doi.org/10.37090/jfl.v9i2.342.

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Abtract Diabetes mellitus (DM) is a serious chronic disease that occurs because the pancreas does not produce enough insulin or when insulin is not use effectively in the body. This study aims to analyze the incidence of Drug Related Problems (DRPs) and find out the category of DRPs in outpatients with a diagnosis of type 2 diabetes mellitus at UPT Puskesmas Gedong Air Inpatient for the Bandar Lampung. This research is a nonexperimental research with a descriptive design taken retrospectively. The sampling technique used in this study is total sampling based on the patient's medical record data. Data were analyzed using the classification of DRPs according to Cipolle 2004, then using Medscape Tools as a tool to check potential drug interactions. The results of this study were 61 patients including 29 patients (46%) with DRPs and 33 patients (54%) without DRPs. The number of male patients is 25 patients and the number of female patients is 36 patients with age range 25-45 and 46-65. A total 52 patien Type 2 Diabetes Mellitus have cormobid and 9 patients without comorbid. DRP categories that occur include drugs without indication as much (8%), indications without drugs as much as (15%), and potential drug interactions (48%). The conclusion in this study is that Drug Related Problems (DRPs) have occurred in outpatients diagnosed with type 2 diabetes mellitus in UPT Puskesmas Gedong Air Inpatient with the highest DRPs category is the potential for drug interactions (48%). Key words: Diabetes Mellitus Type 2, Drug Related Problems

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Suryani, Desi, Anton Bahtiar, and Retnosari Andrajati. "PHARMACIST INVOLVEMENT TO DECREASE DRUG-RELATED PROBLEMS AMONG GERIATRIC PATIENTS IN INDONESIAN PRIMARY HEALTH CENTERS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 17 (October 1, 2017): 102. http://dx.doi.org/10.22159/ajpcr.2017.v10s5.23109.

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Objective: The studies have demonstrated that older people often suffer from multiple diseases and are thus prescribed many different drugs. Therefore, drug-related problems (DRPs) are common in the elderly. The main objectives of this study were to reduce the number of DRPs in the elderly through pharmacist involvement and to analyze differences after pharmacist recommendations.Methods: In a quasi-experimental study, 12 primary health centers were selected and randomly divided into two groups (six in each group). In the first group, the physicians received pharmacist recommendations verbally through discussions, and in the second group, the physicians received recommendations through letters. DRPs were analyzed from all older inpatients’ medical records 1 month before and 1 month after the pharmacist recommendations. The main outcome being measured was the incidence of DRPs, classified into problems, and causes according to the Indonesian translated version of Pharmaceutical Care Network Europe, Version 6.2 (PCNE V 6.2). The problems were identified based on journal articles and other relevant literature.Results: A total of 205 patients were analyzed before pharmacist intervention (Group 1: 121; Group 2: 84) and 202 patients after the intervention (Group 1: 108; Group 2: 94). The most common problem in these elderly patients was that they suffered from toxic effects. The most common cause was inappropriate drug selection. The number of DRPs and causes were decreased significantly through the discussions (Wilcoxon signed-rank test, problems p=0.027, causes p=0.028). DRPs were also significantly decreased through the recommendation letters (paired t-test, number of problems p=0.003, and causes p=0.004). Discussion with physicians seemed more effective and decreased more problems (p=0.001) and causes (p=0.002). Through discussions, the decrease in a number of problems was 20.83±8.931, and the decrease in the number of causes was 25.33±11.431 versus the recommendation letter, at 4.17±1.941 and 5.17±2.483, respectively.Conclusion: Pharmacist involvement decreased DRPs among older inpatients. Discussing DRPs with the physicians treating the patients is more effective than giving recommendations in writing only. The PCNE V 6.2 DRP classification system is useful for documenting DRPs among the elderly as it can help pharmacists develop plans to reduce DRPs.

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Adiana, Sylvi. "Kajian Drug Related Problems (DRPs) Pasien Geriatri di Rawat Jalan Rumah Sakit Universitas Andalas." SCIENTIA : Jurnal Farmasi dan Kesehatan 10, no. 1 (February 28, 2020): 104. http://dx.doi.org/10.36434/scientia.v10i1.300.

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Hipertensi adalah penyakit kardiovaskular yang paling sering terjadi. Diabetes Melitus merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena sekresi insulin, kerja insulin atau kedua-duanya. Pasien usia lanjut (geriatri) adalah seseorang yang mencapai usia 60 (enam puluh tahun) ke atas. Pasien usia lanjut umumnya mengalami penurunan fungsi organ dan menerima bebagai macam obat, sehingga rentan Drug Related Problems (DRPs). Drug Related Problems (DRPs) merupakan suatu kondisi terkait dengan terapi obat yang secara nyata atau potensial mengganggu hasil klinis kesehatan yang diinginkan. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisa Drug Related Problems (DRPs) pasien geriatri di Rawat Jalan Rumah Sakit Universitas Andalas. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dari 82 rekam medis periode April Juli 2019 di Rawat Jalan Rumah Sakit Universitas Andalas. Hasil penelitian menunjukkan yang mengalami kejadian DRPs. Kategori DRPs yang teridentifikasi, meliputi indikasi tanpa terapi 1 pasien (1,2%), dosis berlebih 1 pasien (1,2%) dan interaksi obat 13 pasien (15,85%).

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Tuloli, Teti S., Mahdalena Sy. Pakaya, and Susi Dwi pratiwi. "Identifikasi Drug Related Problems (DRPs) Pasien Hipertensi di RS Multazam Kota Gorontalo." Indonesian Journal of Pharmaceutical Education 1, no. 1 (March 3, 2021): 1–9. http://dx.doi.org/10.37311/ijpe.v1i1.9945.

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Hypertension is a disease that continues to increase every year, where the keys to success for its treatment are selection and use of the drugs. The treatment failure occurred if the selection and use of medication are inappropriate with the condition of patients followed by DRPs. Unresolved hypertension can cause heart attack, kidney failure and stroke. The research aimed to identify DRPs at hypertension patients with or whitout comorbidity reviewed from the drug without indication, indication without drug, high doses, low doses, and drug interaction. The research was non-experimental descriptive research which applied cross-sectional design by collecting data through a retrospective at hypertension with or without comorbidity at Multazam Hospital of Gorontalo City for January-December 2018 periods. The samples were selected by purposive sampling and obtained 79 patients who were qualified as samples. The obtained data were analyzed with univariate. The finding of research showed that the use of medication at hypertension patient with or without comorbidity at Multazam Hospital of Gorontalo City for January-Desember 2018 periods based on five categories were drug without indication was 3.08%, indication without drug was 33,84%, high doses was 27,70%, low doses was 4,62% and drug interaction was 30,76%. The identification of DRPs of use of hypertension medication with or without comorbidity at Multazam Hospital of Gorontalo City for January-December 2018 periods was categorized good.

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Jamal, Irsa, Fatima Amin, Anam Jamal, and Amna Saeed. "Pharmacists interventions in reducing the incidences of drug related problems in any practice setting." International Current Pharmaceutical Journal 4, no. 2 (January 7, 2015): 347–52. http://dx.doi.org/10.3329/icpj.v4i2.21483.

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A drug-related problem is an event or circumstance involving drug treatment that actually or potentially interferes with the patients experiencing an optimum outcome of medical care. The pharmacists can play key role in reducing the incidences of DRPs by making appropriate intervention at each stage and by working with other healthcare professionals. The aim of this study was to observe the Pharmacist clinical knowledge about DRPs and the extent to which they participate in reducing the incidences of DRPs. A questionnaire based survey was conducted among hundred pharmacists selected by random sampling in different health care settings from Lahore district. According to data collected it was found that 100% of Pharmacists had knowledge about DRPs and Pharmaceutical care. Different types of DRPs were identified by Pharmacists but only 41% of Pharmacists reported these DRPs and 37% of Pharmacists intervened to reduce the incidences of DRPs. Majority of the Pharmacists had knowledge about DRPs, other related terms and also about reporting but most of them did not actively participate to reduce incidences of DRPs because of lack of their acceptance by society and other health care professionals, lack of proper reporting system, lack of incentives and lack of time due to managerial job structure specially in case of retail pharmacy setup.DOI: http://dx.doi.org/10.3329/icpj.v4i2.21483 International Current Pharmaceutical Journal, January 2015, 4(2): 347-352

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Sarfaraz, Mohammed, Binu Mathew, and Sanjay Poudel. "ASSESSMENT OF DRUG RELATED PROBLEMS IN A TERTIARY CARE TEACHING HOSPITAL, INDIA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (February 1, 2017): 310. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15678.

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ABSTRACTObjective: Drug related problems (DRPs) are frequent in hospitalization where multiple changes in patient’s medication regimen and lack of continuity of care may be accompanied. The aim of present research was to identify drug related problems, drug classes involved in DRPs as well as associated factors with the occurrence of DRPs and to assess the pharmacist interventions in a tertiary care teaching hospital.Methods: A prospective observational study was carried out in a tertiary care teaching hospital, over a period of six months from November 2015 to April 2016. All the in patients admitted to all departments of hospital, who satisfied the selection criteria, were included in this study. Necessary demographic and clinical data was collected from the case records. The Pharmaceutical Care Network Europe Classification Version (PCNE) 5.01 was used to classify DRPs. The treatment data was analyzed to determine the rate, pattern, clinical significance, and outcomes of DRPs.Results: A total of 300 patient case sheets were reviewed during the study period, out of which 143 drug related problems were identified from 93 patients. Male (%) predominance was noted over females (%). The most common DRP was drug Interactions 47.55% (68) followed by drug use problems 19.58% (28), drug choice problems 14.68% (21), others 11.88% (17), dosing problems 4.89% (7), and adverse reaction 1.39% (2) were identified.Conclusion: Drug related problems are common among the wards of hospital. Clinical pharmacist’s role in identification, resolution and prevention of drug related problems helps in achieving better therapeutic outcomes and improved patient healthcare.Keywords: DRP’s, Adverse Drug Reactions, Drug Interactions (DI), Drug choice problems, Dosing problem, Drug use problems, Paediatric, Medicine, PCNE

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Hartuti, Silvy, Azizah Nasution, and Santi Syafril. "The Effect of Drug-Related Problems on Blood Glucose Level in the Treatment of Patients with Type 2 Diabetes Mellitus." Open Access Macedonian Journal of Medical Sciences 7, no. 11 (June 16, 2019): 1798–802. http://dx.doi.org/10.3889/oamjms.2019.290.

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AIM: The study aimed to investigate the effect of drug-related problems (DRPs) on changes in blood glucose level (BGL) in the treatment of type 2 diabetes mellitus (T2DM) patients.METHODS: This three-month prospective cross-sectional study was conducted to patients of T2DM with complications hospitalised in Haji Adam Malik (HAM) Hospital, Medan, Indonesia period from July to October 2018. DRPs were identified and classified by using Cipolle DRP classification and trustable literature. The data obtained were analysed by Chi-Square test (p < 0.05 implied that there was a significant relationship).RESULTS: This study involved 81 T2DM patients, 52 (64.2%) of the patients were male, and 29 (35.8%) of them were female. Most (30.9%) of patients were at the age of 51-60 years. Combination of rapid-acting and long-acting insulin was the most frequently provided antidiabetic drugs (69.1%). There were 68 DRPs experienced by 32 (39.5%) of the patients. Percentage of DRP experienced by the 32 patients by number: 1 DRP, 53.1; 2 DRPs, 28.1; 3 DRPs, 3.1; 4 DRPs, 3.1; 5 DRPs, 3.1; 7 DRPs, 9.3. This study showed that 27.2% and 12.3 % of the patients had hyperglycemia and hypoglycemia, respectively. There was no significant relationship between BGL and indication without drug therapy (p = 0.064), ineffective provided drug (p = 0.079), and there was a significant relationship between BGL and irrational dose (p = 0.000). Furthermore, there was a significant relationship between hypoglycemia and adverse drug reaction (p = 0.000).CONCLUSION: DRPs are common among T2DM patients and still required the attention and appropriate actions of healthcare providers.

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Pathalung, Parina Na, and Phayong Thepaksorn. "Abilities of Village Health Volunteers in Determining Drug Related Problems for Diabetes and Hypertension Patients." International Journal of Public Health Science (IJPHS) 6, no. 4 (December 1, 2017): 283. http://dx.doi.org/10.11591/ijphs.v6i4.9436.

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The objective of this study was to assess the Village Health Volunteers (VHVs) on their knowledge and skills for determining drug-related problems (DRPs) for hypertension (HTN) and diabetes (DM) patients. This study was conducted among 36 VHVs between March and October, 2014 in ten districts of Trang Province. The semi-structured questionnaire interviews and tests have been developed according to knowledge and skills based health determinants for DRPs. The DRPs training program was assigned including, 1) a short course training (2-day) and hands-on training (1-week) followed up, 2) field work for determining DRPs (16-week) and 3) an assessment for determining DRPs in knowledge and competent skills. All completed data of 25 female VHVs were analyzed with age of 42.93 years old on average. About 68% were age higher than 40 years old and most of them were Para rubber farmers (76%). Most of them had a primary education level (60%) and almost a half had more than ten years in VHVs’ service (n =12; 48%). Their knowledge scores for determining DRPs were 12.88 on average, in total of 15 points. Their overall scores for skills presented were 35.48 out of 50 points in total. In conclusion, this program can enhance VHVs’ abilities for determining DRPs for HTN and DM patients. Our findings may contribute to future development of VHVs program for improving VHVs competent skills for DRPs chronic diseases.

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Meila, Okpri, and Handika Indri Rochana. "Kajian Drug Related Problems (DRPs) Terhadap Pengobatan Pasien Stroke Iskemik di Rumah Sakit Pusat Otak Nasional Jakarta Periode Januari – Desember 2015 S." Pharmacon: Jurnal Farmasi Indonesia 14, no. 2 (March 14, 2019): 48–53. http://dx.doi.org/10.23917/pharmacon.v14i2.5765.

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This study aims to determine the percentage of DRPs of ptients with ischemic stroke at Brain Center National Hospital Jakarta. Based on data from the WHO 2006, each year there are approximately 13 million new stroke patients of which approximatelly 4,4 million of them die within 12 months.When patients undergo a treatment, most patients achieve optimal results that heal diseases suffered by patients but not least the failure in therapy. Therefore, the contribution required to identify, resolve and prevent problems in drug therapy known as Drug Related Problems (DRPs). The method used in this study is cross sectional. Total sample data obtained as many as 360 samples. The results showed indications without drugs of 55.62%, drugs without indication of 15.17%, drug interactions of 10.11%, patients fail to receive the drug of 7.86%, side effects of 6.18% and less drug selection right of 5.06%. Data show that the highest percentage of DRPs are indications without drugs.

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Stevani, Hendra, Seli Sulfiana, and Andi Muh Farid. "IDENTIFIKASI DRUG RELATED PROBLEMS PADA PASIEN DIABETES MELITUS TIPE II DENGAN KOMPLIKASI HIPERTENSI DI INSTALASI RAWAT INAP RSUD LABUANG BAJI KOTA MAKASSAR PERIODE JANUARI-JUNI 2016." Media Farmasi 13, no. 2 (May 25, 2019): 54. http://dx.doi.org/10.32382/mf.v13i2.883.

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Hipertensi merupakan penyakit yang sering ditemukan pada penderita diabetes mellitus, adanya penyakit komplikasi tersebut dapat berpotensi menimbulkan kejadian Drug Related Problems. Penelitian ini bertujuan untuk mengidentifikasi tingkat kejadian DRPs pada pasien diabetes melitus tipe 2 dengan komplikasi hipertensi di instalasi rawat inap RSUD Labuang Baji Kota Makassar periode Januari-Juni 2016. Jenis penelitian ini adalah deskriptif observasional dengan pengambilan data secara retrospektif, sampel diambil dengan metode purposive sampling. Analisis data dilakukan dengan melihat hasil rekam medik berupa riwayat pengobatan dan disimpulkan dengan menghitung jumlah kategori DRPs yang terjadi pada pasien. Hasil penelitian menunjukkan adanya kejadian Drug Related Problems (DRPs) pada pasien diabetes malitus tipe 2 dengan komplikasi hipertensi di Instalasi Rawat Inap RSUD Labuang Baji Kota Makassar periode Januari-Juni 2016. Kategori Drug Related Problems (DRPs) yang terjadi pada pasien diabetes malitus tipe 2 dengan komplikasi hipertensi di Instalasi Rawat Inap RSUD Labuang Baji Kota Makassar periode Januari-Juni 2016 adalah indikasi yang tidak ditangani.Kata kunci : Drug Related Problems (DRPs), DM tipe 2, Hipertensi, RSUD Labuang Baji Kota Makassar

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Westerlund, LO Tommy, Wolfgang HA Handl, Bertil RG Marklund, and Peter Allebeck. "Pharmacy Practitioners' Views on Computerized Documentation of Drug-Related Problems." Annals of Pharmacotherapy 37, no. 3 (March 2003): 354–60. http://dx.doi.org/10.1345/aph.1c182.

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OBJECTIVE: To evaluate the practice by community pharmacy practitioners of computerized documentation of drug-related problems (DRPs) and pharmacy interventions in nonprescription drug consumers. METHODS: A questionnaire was administered in December 1999 to pharmacy practitioners in 45 community pharmacies of different sizes and locations across Sweden to survey their attitudes and experiences after participation in a 10-week period of computerized DRP documentation. RESULTS: The participants (n = 376, response rate 84%) found the development of computerized documentation of DRPs and pharmacy interventions to be very important. The instrument was perceived as easy to learn and to work well in daily practice. The documentation made many practitioners more attentive to the drug-related needs of self-care consumers and changed their perception of good quality in self-care counseling. The weighted multiple linear regression analysis showed no correlation between the proportion of practitioners experiencing time constraints and the DRP documentation rate of their work site. However, the magnitude of interest in the documentation practice had a significant effect on the documentation rate, regardless of the extent of the time constraints experienced (p = 0.004). CONCLUSIONS: The positive findings of the evaluation speak in favor of an expanded implementation of computerized documentation of DRPs and pharmacy interventions. Commitment among participating pharmacy practitioners to the new practice is essential and appears to overcome possible time constraints.

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Işık, Merve Nur, Nazan Dalgıç, Betül Okuyan, Zeynep Yıldız Yıldırmak, and Mesut Sancar. "Medication Review for Hospitalized Pediatric Patient: Clinical Pharmacist Interventions." Journal of Pediatric Infection 54, no. 4 (December 15, 2020): 218–24. http://dx.doi.org/10.5578/ced.202067.

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Objective: The aim of this study is to evaluate clinical pharmacist-led medication review service for hospitalized pediatric patients. Material and Methods: This cross-sectional study was carried out between November 2017-April 2018 in an education and research hospital in Istanbul. Clinical pharmacist-led medication review was conducted by using Pharmaceutical Care Network Europe (PCNE) Classification V8.02 in hospitalized pediatric at general pediatric service. Potential drug-related problems (DRPs) were identified and classified. These DRPs were presented the physicians and the percentage of accepted recommendations by the physician were recorded. Results: Among forty-three patients (21 male and 22 female), the median age of them was calculated as 6 (3-36) months. Of them, 25.58% had 16 DRPs. The most common DRPs were associated with potential drug-drug interactions (n= 9); and dose selection (n= 5), which represented 56.25% and 31.25% of drug-related problems, respectively. It was observed that 63% of these problems were occurred during selection of drugs (at prescription level) according to PCNE classification. Of the clinical pharmacist’s recommendations regarding these DRPs, 87.5% were accepted by the physician. Conclusion: To optimize rational drug use, numerous studies related with clinical pharmacist-led medication review by using PCNE classification were present in adult patients; however, there was no sufficient studies conducted in pediatric patients. Clinical pharmacists have an important role in the classification of DRPs and to provide rational drug use in pediatric patients.

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Işık, Merve Nur, Nazan Dalgıç, Betül Okuyan, Zeynep Yıldız Yıldırmak, and Mesut Sancar. "Medication Review for Hospitalized Pediatric Patient: Clinical Pharmacist Interventions." Journal of Pediatric Infection 54, no. 4 (December 15, 2020): 237–43. http://dx.doi.org/10.5578/ced.69774.

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Objective: The aim of this study is to evaluate clinical pharmacist-led medication review service for hospitalized pediatric patients. Material and Methods: This cross-sectional study was carried out between November 2017-April 2018 in an education and research hospital in Istanbul. Clinical pharmacist-led medication review was conducted by using Pharmaceutical Care Network Europe (PCNE) Classification V8.02 in hospitalized pediatric at general pediatric service. Potential drug-related problems (DRPs) were identified and classified. These DRPs were presented the physicians and the percentage of accepted recommendations by the physician were recorded. Results: Among forty-three patients (21 male and 22 female), the median age of them was calculated as 6 (3-36) months. Of them, 25.58% had 16 DRPs. The most common DRPs were associated with potential drug-drug interactions (n= 9); and dose selection (n= 5), which represented 56.25% and 31.25% of drug-related problems, respectively. It was observed that 63% of these problems were occurred during selection of drugs (at prescription level) according to PCNE classification. Of the clinical pharmacist’s recommendations regarding these DRPs, 87.5% were accepted by the physician. Conclusion: To optimize rational drug use, numerous studies related with clinical pharmacist-led medication review by using PCNE classification were present in adult patients; however, there was no sufficient studies conducted in pediatric patients. Clinical pharmacists have an important role in the classification of DRPs and to provide rational drug use in pediatric patients.

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Kawengian, Sartika, Weny Indayany Wiyono, and Marina Mamarimbing. "IDENTIFIKASI DRUG RELATED PROBLEMS (DRPS) PADA TAHAP ADMINISTRATION PASIEN PENYAKIT JANTUNG KORONER DI INSTALASI RAWAT INAP RSUP Prof. Dr. R. D. KANDOU MANADO." PHARMACON 8, no. 1 (February 28, 2019): 1. http://dx.doi.org/10.35799/pha.8.2019.29227.

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ABSTRACT Pharmaceutical care are activities that aim to identify, prevent and resolve drug related problems (DRPs). In the process of pharmacy services, especially in patients who receive many types and amounts of drugs is the risk of medication errors. The more risk factors you have, the more likely you are to get coronary heart disease, causing the complexity of the therapy given. This study aims to determine the characteristics of patients and the percentage of Drug Related Problems (DRPs) at the administration stage of coronary heart disease patients at the inpatient installation of Prof. RSUP DR. R. D. Kandou Manado for the period December 2017 - April 2018. This research was a descriptive study with prospective data retrieval of 38 inpatient CHD medical record data that met the inclusion criteria. The results of the study based on the characteristics of CHD patients showed that the number of male patients was higher than that of females as many as 29 patients (78.38%) and the highest number of patients in the elderly group (60-69) were 15 patients (39.47%). (5-10) types of drugs prescribed in 22 patients (57,90%) and the highest class of drugs in 38 patients (100%) cardiovascular therapy classes and circulatory drug. Percentage of DRPs based on the indication without therapy (10.34%), therapy without indication (10.34%), low drug dose (79.31%), high drug dose (0%), non-compliance (0 %). Keywords: CHD, Drug Related Problems (DRPs), Administration ABSTRAK Pelayanan kefarmasian merupakan kegiatan yang bertujuan untuk mengidentifikasi, mencegah dan menyelesaikan masalah terkait obat/Drug Related Problems (DRPs). Dalam proses pelayanan kefarmasian khususnya pada pasien yang menerima banyaknya jenis dan jumlah obat merupakan resiko terjadinya kesalahan pengobatan (medication errors). Semakin banyak faktor resiko yang dimiliki, semakin berlipat pula kemungkinan terkena penyakit jantung koroner menyebabkan kompleksnya terapi yang diberikan. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dan presentase Drug Related Problems (DRPs) pada tahap administration pasien penyakit jantung koroner di instalasi rawat inap RSUP Prof. DR. R. D. Kandou Manado periode Desember 2017 - April 2018. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara prospektif terhadap 38 data rekam medik pasien PJK rawat inap yang memenuhi kriteria inklusi. Hasil penelitian berdasarkan karakteristik pasien PJK menunjukkan jumlah pasien laki-laki lebih banyak dibandingkan perempuan yaitu sebanyak 29 pasien (78,38%) dan jumlah pasien terbanyak pada kelompok usia lansia (60 – 69) sebanyak 15 pasien (39,47%). Hasil penelitian terkait menunjukkan bahwa mayoritas pasien PJK menerima menerima (5 – 10) jenis obat yaitu sebesar 22 pasien (57,90%) dan golongan obat yang paling banyak digunakan oleh pasien PJK yaitu golongan obat dengan kelas terapi kardiovaskular dan golongan obat yang mempengaruhi darah sebanyak 38 pasien (100%). Presentase DRPs indikasi tanpa terapi sebesar (10,34%), terapi tanpa indikasi sebesar (10,34%), dosis obat rendah sebesar (79,31%), dosis obat tinggi sebesar (0%), ketidakpatuhan (0%). Kata kunci : PJK, Drug Related Problems (DRPs), Administration

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Matveev, A. V., A. E. Krasheninnikov, E. A. Egorova, and E. I. Konyaeva. "APPLICATION OF DRUG-RELATED PROBLEMS APPROACH TO ANALYSIS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS’ SAFETY." Pharmacy & Pharmacology 7, no. 4 (September 10, 2019): 215–23. http://dx.doi.org/10.19163/2307-9266-2019-7-4-215-223.

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A Drug-Related Problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes.The aim of the study was the analysis of the adverse drug reactions (ADR) associated with prescription of the non-steroidal anti-inflammatory drugs (NSAIDs) using the DRP PCNE V5.01 qualification system.Materials and methods. The objects of the study were 415 notification forms about adverse drug reactions of NSAIDs recorded in the regional database of spontaneous reports and called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 1 January 2009 to 31 December of 2018. The study and analysis of the problems associated with drugs were carried out using the qualification system DRP PCNE V5.01 (Pharmaceutical Care Network Europe) 2006 in the modification of Prof. Zimenkovsky.Results. Among other representatives of the NSAID group, Ibuprofen and Diclofenac became the “leaders” in the incidence of ADR. The frequency of ADR cases for Ibuprofen was 142 reports (34.22% of the total number of ADR for NSAIDs), and for Diclofenac it was 90 cases (21.69%). The calculation of DRP values for each of the presented cases made it possible to determine that in 81 (19.51%) and 91 (21.9%) cases, the DRP value was 6 and 7, respectively. DRP values in the range of 8–10 were found in 92 reports. The highest DRPs value was observed after the administration of Parecoxib (13 problems but only one case was found in the database), the DRPs value of Dexketoprofen was 12.5 (95% CI: 7–17) and the DRPs value of Diclofenac combinations was 10 DRPs; 95% CI: 5–17 DRP). The minimum DRPs values were associated with Naproxen, Rofecoxib, and Etoricoxib prescriptions.Conclusion. Using the DRP system in the analysis of NSAIDs, ADRs allow to identify the medicines which have a high risk of causing safety problems, such as Parecoxib, Dexketoprofen and Diclofenac combinations. The prescription of these drugs should be carried out with special cautions and control to the indications and contraindications, the dose and duration of treatment, as well as to a possible interaction of them with concomitant drugs.

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Nascimento, Yone de Almeida, Wânia da Silva Carvalho, and Francisco de Assis Acurcio. "Drug-related problems observed in a pharmaceutical care service, Belo Horizonte, Brazil." Brazilian Journal of Pharmaceutical Sciences 45, no. 2 (June 2009): 321–30. http://dx.doi.org/10.1590/s1984-82502009000200018.

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This present observational, longitudinal, and non-concurrent study was developed with the purposes of evaluate the profile of patients attended by a pharmacotherapeutic follow-up service and describe the Drug-Related Problems (DRPs) found over there; determine the proportion of DRPs between the health problems presented by the studied population, classifying them and identifying the situations related with their appearance. The study was developed at the School Pharmacy of Newton Paiva University Center, Belo Horizonte, MG, during the period from 2001 November up to 2003 November. Ninety seven patients have been evaluated, the majority of female sex (66.0%), with up to 8 years of scholarship (45.4%), mean age of 56.7 ± 13.0 years; mean of 4 ± 2 diagnosed diseases; 7 ± 6 complaints and 4 ± 2 medications per patient. Nine hundred and twelve health problems have been identified: 56.5% uncontrolled. From the uncontrolled problems, 380 (73.6%) were DRPs and between these, 81 (21.3%) were risks for DRP. From the 97 followed-up patients, 89 (91.7%) have presented at least one DRP during the follow-up. The more frequent DRPs were related to effectiveness (53.2%), to necessity (25.2%) and to safety (21.6%). A great number of uncontrolled problems was observed, as well as the possibility to resolve them by means of pharmaceutical care, indicating so the resolutive potential of this practice.

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Arlinda, Arlinda, Alwiyah Mukaddas, and Ingrid Faustine. "IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) PADA PASIEN ANAK GASTROENTERITIS AKUT DI INSTALASI RAWAT INAP RSU ANUTAPURA PALU." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 2, no. 1 (March 4, 2016): 43–48. http://dx.doi.org/10.22487/j24428744.2016.v2.i1.5302.

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Acute gastroenteritis, one of the most common disease in children and one of the causes of children’s death in the world, has a great chance of the occurrence of Drug Related Problems (DRPs). This study aimed to determine the incidence of potential DRPs occurred in pediatric inpatients of acute gastroenteritis in Anutapura General Hospital, Palu, Central Sulawesi. This was a prospective observational study done by collecting primary data from the observation and secondary data from medical records of pediatric inpatients aged from 1 month to 14 years and diagnosed with acute gastroenteritis with or without dehydration. Data were then analyzed and descriptively presented including drug use without indication, wrong drug, drug dose too low, drug dose loo high, and untreated indication. The results showed that there were 115 cases of DRPs. The most DRPs found was drug use without indication as many as 56 cases (48.7%), while the others successively were drug dose too low 26 cases (22.6%), untreated indication 16 cases (14%), drug dose too high 15 cases (13%), and wrong drug 2 cases (1.7%)

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Purba, Eva Dewi, Khairunnisa M, and Hasibuan Poppy Anjelisa. "Assessment of Drug Related Problems among Type 2 Diabetes Mellitus Patients with Hypertension in Doloksanggul Hospital, North Sumatera: A Retro prospective Study." Asian Journal of Pharmaceutical Research and Development 7, no. 6 (December 14, 2019): 46–50. http://dx.doi.org/10.22270/ajprd.v7i6.626.

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Objective: The aim of this study was to assess the drug-related problems (DRPs) in Type 2 diabetes mellitus(T2DM) patients whom also diagnosed with hypertension. Methods: The retrospective study was conducted from October to December 2018 at Doloksanggul Hospital in North Sumatera, Indonesia involving 42 T2DM with hypertension patients according to research inclusion criteria. The assessment of DRPs was based on the Pharmaceutical Care Network Europe (PCNE) tools version 8.01. Results: This study identified 41 DRPs, averaging 0.98±0.24 DRPs per patient. The majority of problems were treatment effectiveness problems 97.62% (41 patients) while the patient related was the main causes (47.24%). The most intervention was conducted at patient level (71.62%).Conclusion: Early detection of DRPs by pharmacist are essential to prevent DRPs and to ensure the effectiveness of drug therapy.

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Bekele, Firomsa, Tesfaye Tsegaye, Efrem Negash, and Ginenus Fekadu. "Magnitude and determinants of drug-related problems among patients admitted to medical wards of southwestern Ethiopian hospitals: A multicenter prospective observational study." PLOS ONE 16, no. 3 (March 16, 2021): e0248575. http://dx.doi.org/10.1371/journal.pone.0248575.

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Background Drug-related problem (DRP) is an event involving drugs that can impact the patient’s desired goal of therapy. In hospitalized patients, DRPs happen during the whole process of drug use such as during prescription, dispensing, administration, and follow-up of their treatment. Unrecognized and unresolved DRPs lead to significant drug-related morbidity and mortality. Several studies conducted in different hospitals and countries showed a high incidence of DRPs among hospitalized patients. Despite the available gaps, there were scanties of studies conducted on DRPs among patients admitted to medical wards in Ethiopia. Therefore, this study assessed the magnitude of drug-related problems and associated factors among patients admitted to the medical wards of selected Southwestern Ethiopian hospitals. Patients and methods A multicenter prospective observational study was conducted at medical wards of Mettu Karl Hospital, Bedele General Hospital and Darimu General Hospital. Adult patients greater than 18 years who were admitted to the non-intensive care unit (ICU) of medical wards and with more than 48 h of length of stay were included. Identified DRPs were recorded and classified using the pharmaceutical care network Europe foundation classification system and adverse drug reaction was assessed using the Naranjo algorithm of adverse drug reaction probability scale. Hill-Bone Compliance to High Blood Pressure Therapy Scale was used to measure medication adherence. Multivariable logistic regression was used to analyze the associations between the dependent variable and independent variables. Result Of the 313 study participants, 178 (56.9%) were males. The prevalence of actual or potential DRPs among study participants taking at least a single drug was 212 (67.7%). About 125 (36.63%) patients had one or more co-morbid disease and the average duration of hospital stay of 7.14 ± 4.731 days. A total of 331 DRPs were identified with an average 1.06 DRP per patient. The three-leading categories of DRPs were unnecessary prescription of drugs 92 (27.79%), non-adherence (17.22%) and dose too high (16.92%). The most common drugs associated with DRPs were ceftriaxone (28.37%), cimetidine (14.88%), and diclofenac (14.42%). The area of residence (AOR = 2.550, 95CI%: 1.238–5.253, p = 0.011), hospital stay more than 7 days (AOR = 9.785, 95CI%: 4.668–20.511, p≤0.001), poly pharmacy (AOR = 3.229, 95CI%: 1.433–7.278, p = 0.005) were predictors of drug-related problem in multivariable logistic regression analysis. Conclusion The magnitude of drug therapy problems among patients admitted to the medical wards of study settings was found to be high. Therefore, the clinical pharmacy services should be established in hospitals to tackle the DTPs in this area. Additionally, healthcare providers of hospitals also should create awareness for patients seeking care from health facilities of the importance of rational drug usage.

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Rosmiati, Karolina. "IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) PADA PASIEN GAGAL JANTUNG KONGESTIF DI BANGSAL INTERNE RSUP DR. M. DJAMIL PADANG." Jurnal Sains dan Teknologi Laboratorium Medik 1, no. 1 (June 26, 2018): 12–28. http://dx.doi.org/10.52071/jstlm.v1i1.4.

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Penderita gagal jantung yang menjalani rawat inap seringkali mendapatkan obat dengan jumlah yang banyak sehingga memberikan resiko terjadinya Drug Related Problems (DRPs) yang akan mempengaruhi hasil pada pasien. Penelitian menggunakan desain cross sectional deskriptif analitik dengan melakukan penelitian prospektif pasien gagal jantung kongestif yang menjalani rawat inap di RSUP Dr. M.Djamil Padang selama Februari – Mei 2011. Karakteristik 53 orang subjek penelitian, perempuan lebih banyak dari laki-laki, mengalami DRPs dengan pemberian furosemid dan captopril. Hasil analisis statistik korelasi antara jumlah obat dengan DRPs yang timbul (P > 0,05), DRPs dengan Length of Stay (LOS) ; (P > 0,05), jumlah obat dengan LOS menunjukkan ada korelasi yang signifikan (P > 0,05). DRPs yang paling banyak terjadi adalah interaksi obat, disususul reaksi efek samping obat, obat yang paling banyak menimbulkan DRPs adalah furosemid dan captopril, kajian hubungan antara jumlah obat dengan DRPs menunjukkan tidak ada korelasi, kajian hubungan DRPs dengan LOS menunjukkan tidak ada korelasi, kajian hubungan jumlah obat dengan LOS menunjukkan ada korelasi dan outcomes dari DRPs yang timbul adalah faktor resiko penyakit kronis akan meningkat dan tidak terjadi efek klinik.

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Susanto, Verlita Evelyn, Adji Prayitno Setiadi, Bobby Presley, Steven Victoria Halim, and Eko Setiawan. "Profil Kerapuhan dan Masalah terkait Obat pada Kelompok Lanjut Usia di Panti Jompo Kota Surabaya." JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) 9, no. 4 (December 31, 2019): 225. http://dx.doi.org/10.22146/jmpf.38869.

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Frailty and drug related problems (DRPs) are common among elderly who lives in the nursing home. There is currently limited information available regarding the profile of frailty and DRPs among elderly living in the nursing homes in Indonesia. This project aims to describe the profile of frailty and DRPs among nursing home residents in Surabaya. This cross-sectional study was conducted in three nursing homes in Surabaya. Integrated Systematic Care for older People (ISCOPE) questionnaire was used to identify the frailty profile among participants. Beers Criteria, screening tool of older person’s prescriptions (STOPP), geriatric dosage handbook and drug interactions analysis and management were used as tools to identify and analyse drug related problems in this study. Several DRPs were identified in this study including inappropriate drug choices, drugs interaction, and inappropriate dose of drugs. In total, 68 elderly were recruited in this study and 41.18% of them were classified as frail older people. There was no drugs interaction with “clinical significance” being identified, however, inappropriate dose of drugs and potentially inappropriate drug choices were found in 58.82% and 19.12% of nursing home residents, respectively. Findings regarding the profile of frailty and DRPs among elderly may indicate the needs to implement an appropriate intervention strategic in order to optimize the use of medications among nursing homes-dwelling elderly people.

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Nasution, Azizah, Aminah Dalimunthe, and Khairunnisa Khairunnisa. "Pharmacists Intervention Reduced Drug-Related Problems in the Treatment of Patients with Type 2 Diabetes Mellitus." Open Access Macedonian Journal of Medical Sciences 7, no. 22 (November 14, 2019): 3856–60. http://dx.doi.org/10.3889/oamjms.2019.519.

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BACKGROUND: Type 2 Diabetes Mellitus (T2DM) remains as a global public health problem, including Indonesia due to its continuous increasing prevalence. AIM: To analyze the impact of pharmacist intervention on drug-related problems (DRPs) occurred in the management of patients with T2DM admitted to Tebing Tinggi Hospital (TTH), Indonesia, period March through August 2018. METHODS: This six-month retrospective prospective cohort study evaluated the impact of pharmacist intervention on the occurrence of DRPs in the management of patients with T2DM (n = 45) insured by Social Security Organizing Body in TTH, North Sumatera, Indonesia. The inclusion criteria were T2DM patients with age ≥ 18 years and under treatment of antidiabetic drugs. A questionnaire was used to assess the characteristics of the patients and antidiabetic drugs provided. The incidence of DRPs in groups with usual care for the previous three-month and with pharmacist interventions for the next three-month admissions were analyzed using Pharmaceutical Care Network Europe (PCNE) DRP classification system version 8.01 that consists of 3 primary domains for problems, 8 primary domains for causes, and 5 primary domains (PCNE, 2017) and trustable literatures. The obtained data were analyzed using descriptive statistics and paired t test in the program of Statistical Package for the Social Sciences version 19 (p < 0.05 was considered significant). RESULTS: Most (66.7%) of the patients were female. Their mean age was 61.96 ± 6.45 (years). The three most widely provided drugs were metformin, glimepirid, and gliclazide. Total incidence of DRPs in groups with: usual care, 128; intervention, 39. There was a significant difference between the incidence of DRPs in groups with usual care and intervention, p ≤ 0.001. CONCLUSION: Pharmacist intervention reduced the incidence of DRPs in the management of T2DM patients.

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Aditamasari, Desi A., Hanggara Arifian, and Adam M. Ramadhan. "Analisis Drug Related Problems (DRPs) pada Pasien Acute Coronary Syndrome Di RSUD Abdul Wahab Sjahranie Samarinda." Proceeding of Mulawarman Pharmaceuticals Conferences 8 (December 31, 2018): 184–90. http://dx.doi.org/10.25026/mpc.v8i1.322.

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Pemakaian obat yang cukup banyak atau disebut polifarmasi pada pasien acute coronary syndrome dapat menyebabkan terjadinya Drug Related Problems (DRPs). Analisis DRPs perlu dilakukan untuk mengoptimalkan terapi yang diberikan. Tujuan penelitian yaitu untuk mengetahui karakteristik dan jumlah kejadian DRPs pada pasien acute coronary syndrome. Penelitian ini menggunakan rancangan penelitian observasional. Data diambil secara prospektif dengan mencatat rekam medik pasien dan dianalisis secara deskriptif. Kriteria inklusi adalah pasien acute coronary syndrome, dewasa, dan rawat inap di RSUD Abdul Wahab Sjahranie Samarinda dalam rentang periode Agustus-Oktober 2018. Hasil penelitian menunjukkan analisis DRP’s yang ditemukan yaitu indikasi tanpa obat (13,33%), overdose (3,33%), adverse drug reaction (20%) dan drug interactions (80%).

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Sagita, Vina A., Anton Bahtiar, and Retnosari Andrajati. "Evaluation of a Clinical Pharmacist Intervention on Clinical and Drug-Related Problems Among Coronary Heart Disease Inpatients: A pre-experimental prospective study at a general hospital in Indonesia." Sultan Qaboos University Medical Journal [SQUMJ] 18, no. 1 (April 4, 2018): 81. http://dx.doi.org/10.18295/squmj.2018.18.01.013.

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Objectives: This study aimed to evaluate the role of a clinical pharmacist intervention in decreasing subsequent clinical and drug-related problems (DRPs) among coronary heart disease (CHD) inpatients with at least one previous DRP. Methods: This pre-experimental study with a pre-post design was carried out from January to April 2017 among inpatients with at least one previous DRP at a general hospital in Tangerang District, Banten, Indonesia. Clinical and DRPs were documented prospectively by a clinical pharmacist, with DRPs classified using Version 6.2 of the DRP classification scheme of the Pharmaceutical Care Network Europe Foundation. The intervention consisted of a discussion of identified DRPs with physicians, patients, pharmaceutical logistics clerks, nurses and nutritionists. Following this, any subsequent clinical and DRPs were re-identified and further interventions were conducted as necessary. Results: A total of 75 inpatients were included in the study. Pre-intervention, there were 443 DRPs and 202 clinical problems. The most frequent DRPs were adverse drug reactions (52.6%), followed by drug effects (41.8%). Most DRPs were of moderate severity and would have resulted in moderate consequences had the pharmacist not intervened. The interventions resulted in a significant reduction in the number of DRPs, type of DRPs and number of clinical problems (P <0.05 each). Patients with complications were 26.047 times more likely to have no reduction or an increased number of clinical problems compared to patients without complications (P <0.05). Conclusion: Clinical pharmacist interventions were found to reduce subsequent DRPs and clinical problems among CHD patients with at least one previous DRP.

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Li, Qin, Hui Jun Qu, Dan Lv, Ming-Kung Yeh, Shusen Sun, Ling Li, and Yun Liao. "Drug-related problems among hospitalized patients with COPD in mainland China." International Journal of Clinical Pharmacy 41, no. 6 (November 8, 2019): 1507–15. http://dx.doi.org/10.1007/s11096-019-00913-4.

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Abstract Background Data are lacking about the extent of drug-related problems in hospitalized patients with COPD in China. Objective Identify types and causes of drug-related problems and assess interventions performed by pharmacists. Setting Study was conducted in an academic teaching hospital in Shanghai, China. Method Between June 2017 and July 2018, 393 patients admitted to hospital for acute exacerbation of COPD hospitalized were enrolled. Patient demographics and clinical characteristics were collected. The drug-related problems and interventions were recorded and analyzed based on the Pharmaceutical Care Network Europe (PCNE)-DRP V 8.02 classification. Main outcome measures The number, types, causes, interventions, and outcomes of the problems were analyzed. Results A total of 640 DRPs, with 763 corresponding causes, were identified for 393 patients. “Treatment safety P2” was the most common type of problem (54.2%; 347/640), and the most common causes were “drug selection C1” (24.2%; 185/763), “dose selection C3” (21.5%; 164/763) and “treatment duration C4” (17.7%; 135/763). Antibiotics, corticosteroids, and proton pump inhibitors were the three primary medication classes associated with DRPs. Patients, hospitalized for more than eight days, taking ten or more drugs or having renal dysfunctions were more likely to have drug-related problems. Pharmacists totally proposed 1557 interventions to address the problems. Most interventions (91.0%; 1418/1557) were accepted, and 91.6% of the problems were solved. Conclusion The prevalence of drug-related problems among the studied COPD patients was high. Pharmacists can have an important role in addressing the problems and optimizing the safety and effectiveness of therapies for hospitalized COPD patients.

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Chan, Ding-Cheng, Jen-Hau Chen, Hsu-Ko Kuo, Chiung-Jung We, I.-Shu Lu, Lee-Shu Chiu, and Shwu-Chong Wu. "Drug-related problems (DRPs) identified from geriatric medication safety review clinics." Archives of Gerontology and Geriatrics 54, no. 1 (January 2012): 168–74. http://dx.doi.org/10.1016/j.archger.2011.02.005.

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Dijkstra, Nienke E., Carolien Sino, Marieke J. Schuurmans, Marcel L. Bouvy, Aline Bouwes, and Rob R. Heerdink. "POTENTIAL CLINICAL CONSEQUENCES OF ADMINISTRATIVE ISSUES REGARDING MEDICATION IN HOME CARE PATIENTS." Innovation in Aging 3, Supplement_1 (November 2019): S46—S47. http://dx.doi.org/10.1093/geroni/igz038.180.

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Abstract Home care professionals observe drug-related problems (DRPs) as administrative problems (e.g. inconsistent registration of (changes in) drug prescription) and side effects which may have clinical consequences for older patients. This study aims to determine the potential clinical impact of administrative problems. A retrospective descriptive study was performed, using reports of home care professionals of the eHOME system (system that assist monitoring/reporting DRPs). Administrative problems of a one year period were assessed by three experts on potential discomfort/clinical deterioration using a 3-point scale. 309 DRPs of 120 out of 451 patients (age ≥65) were assessed. Problems involved undelivered medication administration record lists (n=103,33.3%), inconsistent registration of drug prescription (n=188,60.9%) and insufficient drug delivery (n=18,5.8%). 58.2% of the DRPs had the potential to cause moderate to severe discomfort or clinical deterioration. The results underlines the importance of the observation function of home care professionals and the need to improve pharmaceutical administration issues.

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Asyikin, Asyhari. "STUDI IDENTIFIKASI DRUG RELEATED PROBLEM’S (DRPs) PADA PASIEN DIARE DI PERAWATAN ANAK RSUD PANGKEP SULAWESI SELATAN." Media Farmasi 13, no. 2 (May 25, 2019): 6. http://dx.doi.org/10.32382/mf.v13i2.787.

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Telah dilakukan Penelitian mengenai ini Drug Related Problems (DRPs) pada pasien diare di perawatan anak RSUD Pangkep Sulawesi Selatan pada bulan Agustus 2017. Penelitian ini termasuk penelitian jenis non-eksperimental, dan bertujuan untuk mengetahui Drug Related Problems (DRPs) pada pasien diare di perawatan anak RSUD Pangkep Sulawesi Selatan periode Januari – April 2017, pengambilan data dilakukan secara restropektif dari catatan rekam medik pasien dan dianalisis secara deskriptif. Pengambilan sampel ditentukan secara purposive sampling dengan kriteria anak yang menderita diare di Perawatan anak RSUD Pangkep periode Januari-April 2017. Hasil penelitian menunjukkan bahwa pasien anak yang menderita diare adalah sebanyak 73 pasien yang didominasi oleh anak yang berjenis kelamin laki-laki sebanyak 42 pasien (57,53%) dengan mayoritas pasien usia 0-1 tahun sebanyak 48 pasien (65,75%). Jenis Drug Related Problems (DRPs) yang paling banyak terjadi adalah ketidaktepatan pemilihan obat antibiotika sebesar 20 kasus (27,40%), diikuti indikasi tanpa obat sebesar 26,03%, dan obat tanpa tanpa indikasi sebesar 10,96%Kata kunci: Diare anak, DRPs, ketidaktepatan pemilihan obat, indikasi tanpa obat, obat tanpa indikasi

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Mongaret, Céline, Léa Aubert, Amélie Lestrille, Victorine Albaut, Pierre Kreit, Emmanuelle Herlem, Natacha Noel, et al. "The Role of Community Pharmacists in the Detection of Clinically Relevant Drug-Related Problems in Chronic Kidney Disease Patients." Pharmacy 8, no. 2 (May 22, 2020): 89. http://dx.doi.org/10.3390/pharmacy8020089.

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Community pharmacists (CPs) have traditionally had limited access to patients’ estimated glomerular filtration rate (eGFR) during the medication-dispensing process. The increasing access to shared electronic health records is making eGFR available, but the skills needed to detect and manage clinically relevant drug-related problems (DRPs) are poorly documented. The primary objective of this study was to investigate the role of CPs in the medication-dispensation process for elderly patients with renal impairment. A total of 70 CPs participated in this 6 month study. Community pharmacists asked all patients ≥65 years to bring their laboratory test values for the next medication-dispensing process. Drug-related problem detection rates were compared between CPs (prospective period) and expert pharmacists (retrospectively). The clinical relevance of each DRP was assessed by nephrologists and general practitioners using an appropriate tool. Community pharmacists recruited n = 442 patients with eGFR < 60 mL/min/1.73 m2 and detected n = 99 DRPs, whereas expert pharmacists detected n = 184 DRPs. The most frequently detected DRPs were dosage problems and contraindications. According to assessment by clinicians, CPs and expert pharmacists identified 54.0% and 84.7% of clinically relevant DRPs, respectively. This study suggests a positive impact of the systematic availability of eGFR to CPs on the detection of several DRPs with clinical relevance.

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Journal articles on the topic 'Drug related problems (DRPs)'

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