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Dissertations / Theses on the topic 'Drug Resistance, Candida tropicalis'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Silva, CecÃlia Rocha da. "Efeito da combinaÃÃo de amiodarona com fluconazol, in vitro, frente a isolados de C.tropicalis resistentes ao fluconazol: novos olhares para antigos fÃrmacos." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10141.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Candida tropicalis Ã uma levedura diplÃide causadora de infecÃÃes superficiais e/ou sistÃmicas, as quais podem ser adquiridas de maneira endÃgena ou exÃgena e podem acometer diversos ÃrgÃos. No Brasil, dentre as espÃcies de Candida spp., a C.tropicalis Ã a segunda espÃcie mais comumente isolada e no CearÃ Ã pouco estudada. Nos dias atuais, temos vivenciado um aumento significativo das infecÃÃes fÃngicas invasivas. PorÃm as drogas antifÃngicas disponÃveis no mercado sÃo restritas a um pequeno nÃmero quando comparadas as antibacter

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2

Magri, Marcello Mihailenko Chaves. "Caracterização molecular e perfil de sensibilidade de Candida tropicalis isoladas em corrente sanguínea e cateter de pacientes internados em hospitais de ensino." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-07022013-115954/.

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Infecções causadas por Candida tropicalis (C. tropicalis) são associados à elevada morbi-mortalidade, e foram consideradas como importantes causas de infecção de corrente sanguínea no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP) de março de 1998 a março de 2001. Adicionalmente, são responsáveis pelo aumento do tempo e dos custos de hospitalização e necessidade de cuidados intensivos. Esse estudo tem como objetivo a caracterização molecular e perfil de sensibilidade de 61 isolados de C. tropicalis a partir de candidemias no HCFMUSP e Universidade Estadua

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3

Makwana, Amit. "Studies on the N-dealkylation of codeine by Candida tropicalis." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278237.

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4

Al-Dhaheri, Rawya. "Drug resistance and apoptosis in Candida biofilms." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1940/.

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Candida species are commonly part of the normal flora in humans; however, they are opportunistic fungal pathogens that are capable of causing a variety of infections in hospitalized and immunocompromised individuals. These infections range from superficial to systemic ones. Many Candida infections involve biofilm formation on the surfaces of implanted devices, such as catheters and prostheses, or host tissues. Candida biofilms are resistant to a range of antifungal agents in current clinical use but the basis of this drug resistance is not clear. The aim of this project was to investigate poss

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Barbosa, Mónica Rodrigues. "Evolution of antifungal drug resistance in Candida albicans." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15332.

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Mestrado em Biologia Molecular e Celular<br>The human pathogen Candida albicans is characterized by the presence of a hybrid tRNA (tRNACAGSer) that can be aminoacylated by both LeuRS and SerRS. This tRNA is responsible for the ambiguity of the CUG codon that can be decoded as serine (97%) and Leucine (3%). Previous studies showed that the level of ambiguity is variable depending on the growth condition of the fungus. These studies also revealed that strains mistranslating at a higher level grew better in the presence of azoles, particularly in the presence of fluconazole. To analyse the effec

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6

Epp, Elias. "Functional genomics in Candida albicans: tackling drug resistance and morphology." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104697.

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The human fungal pathogen Candida albicans is a diploid organism that lacks a complete sexual cycle, thus making functional genetics challenging. Consequently, linking a function to a gene often relies on predictions from other model organisms. In this thesis, I have explored different genetic strategies to address two important aspects of the biology of C. albicans, drug resistance and morphology, which are associated with virulence. Using a reverse genetics approach based on the model Saccharomyces cerevisiae, I first identify and validate a new drug target in C. albicans. Next, I use forwar

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7

Alloush, Habib Mahmoud. "The molecular basis of resistance to 5-fluorocytosine in Candida albicans." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240107.

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8

Dovigo, Lívia Nordi. "Efetividade da terapia fotodinâmica na inativação de Candida spp /." Araraquara : [s.n.], 2007. http://hdl.handle.net/11449/97303.

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Orientador: Ana Cláudia Pavarina<br>Banca: Carlos Eduardo Vergani<br>Banca: Vanderlei Salvador Bagnato<br>Resumo: O surgimento da resistência antifúngica aos tratamentos convencionais tem proporcionado o desenvolvimento de novas modalidades terapêuticas para o tratamento da candidose bucal. Nesse contexto, a utilização da PDT vem sendo sugerida como método alternativo para a inativação de microrganismos patogênicos. Este estudo avaliou a efetividade da PDT na inativação de C. albicans e C. glabrata, ATCC e resistente a fluconazol, por meio da utilização do e da iluminação com LEDs de agente fo

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9

Księżopolska, Ewa 1987. "Genomic changes driving the acquisition of multidrug resistance in Candida glabrata." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672386.

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This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational signatures of drug resistance and cross-resistance to representatives of two clinically important antifungal drug classes, azoles and echinocandins. By combining in vitro evolution with phenotypic screening and comparative genomics analysis we investigated the relationship between genomic changes, fitness and drug susceptibility to shed light on the cellular mechanisms and evo

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10

MacPherson, Sarah A. "Roles of zinc cluster protein transcription factors in conferring drug resistance in Saccharomyces cerevisiae and Candida albicans." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100648.

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Multi-drug or pleiotropic drug resistance (PDR) is a universally acquired mechanism that is evolutionarily conserved. Saccharomyces cerevisiae serves as an excellent model organism for studying this phenomenon in pathogenic fungi, such as Candida albicans. In yeast, PDR is most often mediated by the overexpression of membrane-spanning transporter proteins that act as drug efflux pumps. Their expression is controlled by an intricate network of transcription factors, including many members of the Gal4p superfamily of zinc cluster proteins. Pdr1p, Pdr3p, Pdr8p, Stb5p, Yrm1p, and Yrr1p are all tra

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11

Andrade, Mariana Carvalho [UNESP]. "Efetividade da terapia fotodinâmica mediada pela curcumina em Candida spp." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/97329.

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Made available in DSpace on 2014-06-11T19:28:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-06-17Bitstream added on 2014-06-13T19:58:19Z : No. of bitstreams: 1 andrade_mc_me_arafo.pdf: 1842420 bytes, checksum: 8ab56a86c157ba82b8e80912d3966136 (MD5)<br>O surgimento da resistência antifúngica aos tratamentos convencionais tem exigido o desenvolvimento de novas modalidades terapêuticas para o tratamento da candidíase bucal. Nesse contexto, a Terapia Fotodinâmica (Photodynamic Therapy – PDT) tem sido sugerida como método alternativo para a inativação de microorganismos patogênicos. O

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Dovigo, Lívia Nordi [UNESP]. "Efetividade da terapia fotodinâmica na inativação de Candida spp." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/97303.

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Made available in DSpace on 2014-06-11T19:28:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-03-16Bitstream added on 2014-06-13T20:18:33Z : No. of bitstreams: 1 dovigo_ln_me_arafo.pdf: 987871 bytes, checksum: 23bc47899d421f6557ae321ff6536498 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O surgimento da resistência antifúngica aos tratamentos convencionais tem proporcionado o desenvolvimento de novas modalidades terapêuticas para o tratamento da candidose bucal. Nesse contexto, a utili

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Andrade, Mariana Carvalho. "Efetividade da terapia fotodinâmica mediada pela curcumina em Candida spp. /." Araraquara : [s.n.], 2011. http://hdl.handle.net/11449/97329.

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Orientador: Ana Claudia Pavarina<br>Banca: Eunice Teresinha Giampaolo<br>Banca: Claudia Helena Lovato da Silva<br>Resumo: O surgimento da resistência antifúngica aos tratamentos convencionais tem exigido o desenvolvimento de novas modalidades terapêuticas para o tratamento da candidíase bucal. Nesse contexto, a Terapia Fotodinâmica (Photodynamic Therapy - PDT) tem sido sugerida como método alternativo para a inativação de microorganismos patogênicos. O sucesso da PDT depende, dentre outros fatores do tempo de pré-irradiação (TPI), que é o tempo em que o fotossensibilizador (FS) permanece em co

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Nunes, Thaís Soares Bezerra Santos. "Efeito da N-acetilcisteína em biofilme de Candida albicans /." Araraquara, 2019. http://hdl.handle.net/11449/182012.

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Orientador: Ewerton Garcia de Oliveira Mima<br>Resumo: Candida albicans (Ca) é o principal fungo patógeno humano, responsável por infecções como a candidose orofaríngea e a candidemia. Essas infecções estão fortemente associadas com a formação de biofilmes. O uso abusivo de antifúngicos tem levado ao desenvolvimento de resistência fúngica. As terapias direcionadas aos biofilmes, principalmente contra a matriz extracelular (MEC), são relevantes para o desenvolvimento de novos tratamentos mais eficazes. Um dos agentes que tem demonstrado ação antibiofilme é a N-acetilcisteína (NAC). Assim, o obj

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Popp, Christina [Verfasser], Joachim [Gutachter] Morschhäuser, Wilma [Gutachter] Ziebuhr, and Frank [Gutachter] Ebel. "Evolution of antifungal drug resistance of the human-pathogenic fungus Candida albicans / Christina Popp ; Gutachter: Joachim Morschhäuser, Wilma Ziebuhr, Frank Ebel." Würzburg : Universität Würzburg, 2021. http://d-nb.info/1240614780/34.

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Abrantes, Pedro Miguel dos Santos. "Characterization of Candida species isolated from the oral mucosa of HIV-positive African patients." Thesis, UWC, 2013. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2999_1398842890.

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<p>&nbsp<br></p> <p align="left">One of the most common HIV-associated opportunistic infections is candidiasis, caused by <i><font face="TimesNewRoman,Italic">Candida albicans </font></i><font lang="KO" face="TimesNewRoman">or other </font><i><font face="TimesNewRoman,Italic">Candida </font><font lang="KO" face="TimesNewRoman">species. In immune suppressed subjects, this commensal organism can cause an increase in patient morbidity and mortality due to oropharyngeal or systemic dissemination. Limited information exists on the prevalence and antifungal susceptibility of </font><i><font face="Ti

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Vega, Chacón Yuliana del Pilar. "Susceptibilidade de Candida albicans resistente a fluconazol ao efeito fotodinâmica e inibidores dos sistemas de efluxo /." Araraquara, 2018. http://hdl.handle.net/11449/166350.

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Orientador: Ewerton Garcia de Oliveira Mima<br>Resumo: Um dos principais mecanismos de resistência microbiana são os sistemas de efluxo, que transportam medicamentos antimicrobiano para fora da célula. A eficácia de alguns agentes de inibição dos sistemas de efluxo tem sido reportada para reverter a resistência microbiana e também para potencializar as terapias antimicrobianas. Além disso, métodos alternativos aos agentes antimicrobianos convencionais têm sido investigados, como a Terapia Fotodinâmica antimicrobiana (aPDT). O objetivo desse estudo foi avaliar in vitro o efeito da aPDT e de doi

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18

Panariello, Beatriz Helena Dias. "Influência de alterações genéticas, do fluconazol e de enzimas hidrolíticas na matriz extracelular de biofilmes de candida susceptível e resistente a fluconazol /." Araraquara, 2017. http://hdl.handle.net/11449/152594.

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Orientador: Ana Cláudia Pavarina<br>Abstract: Biofilmes formados por Candida estão relacionados a infecções bucais, como a candidíase. Embora a resistência do biofilme seja multifatorial, a proteção exercida por sua matriz extracelular (MEC) é importante para os altos níveis de resistência a drogas antifúngicas. O conhecimento dos princípios estruturais da MEC possibilita maior compreensão de como atuar para desorganizá-la e melhorar a difusão de agentes antifúngicos para que atinjam mais eficientemente o biofilme, além de, futuramente, possibilitar o desenvolvimento de terapias mais eficazes

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Alves, Fernanda. "Eficácia das terapias fotodinâmica e sonodinâmica como métodos para inativação de espécies de candida. Estudo in vitro e clínico. /." Araraquara, 2017. http://hdl.handle.net/11449/152673.

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Orientador: Ana Cláudia Pavarina<br>Resumo: Este trabalho avaliou a eficácia das Terapias Fotodinâmica Antimicrobiana (aPDT) e Sonodinâmica (SDT) na inativação de espécies de Candida. O estudo 1 avaliou a efetividade da aPDT na inativação de biofilmes de Candida albicans susceptível e resistente ao fluconazol, bem como seus efeitos sobre os fatores de virulência das cepas. Para isso, biofilmes destas cepas foram tratados com aPDT mediada pelo Photodithazine e luz LED. Após a aPDT, as células foram recuperadas e os fatores de virulência avaliados. A capacidade de adesão foi analisada pelos test

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Thomaz, Danilo Yamamoto. "Complexo Candida parapsilosis: identificação molecular das espécies, análise proteômica dos biofilmes por MALDI-TOF MS e investigação de um surto envolvendo isolados clínicos resistentes aos azólicos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-13022019-163819/.

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INTRODUÇÃO: A frequência de Candida parapsilosistem apresentado considerável aumento em UTIs neonatais. Embora a taxa de resistência dessa espécie aos azólicos seja baixa, recentemente têm sido relatados surtos de candidemia por isolados resistentes. A capacidade de adesão e formação de biofilme por essa espécie confere maior potencial patogênico e resistência aos antifúngicos. Portanto, a vigilância epidemiológica, tanto da resistência aos antifúngicos como da virulência dos isolados, é fundamental para o controle e prevenção das infecções e surtoshospitalares. A técnica de MALDI-TOF MS pode

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Brinco, Catarina Alexandra Gomes. "Evolution of antifungal drug tolerance in Candida albicans." Master's thesis, 2018. http://hdl.handle.net/10773/25138.

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Nowadays, fungal infections are a serious public health issue due to the increasing drug resistance and small number of antifungals available. Candida albicans is the most prevalent human fungal pathogen, causing invasive fungal infections that are associated with high mortality rates. This fungus has a particular hybrid tRNA (tRNACAGSer) that is recognized by both the leucyl - and the seryl-tRNA synthetases (LeuRS and SerRS), allowing for incorporation of leucine (3%) and serine (97%) at CUG positions. It has already been shown that in the presence of antifungals, the level of Leu misincorp

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Popp, Christina. "Evolution of antifungal drug resistance of the human-pathogenic fungus \(Candida\) \(albicans\)." Doctoral thesis, 2021. https://doi.org/10.25972/OPUS-24351.

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Infections with the opportunistic yeast Candida albicans are frequently treated with the first-line drug fluconazole, which inhibits ergosterol biosynthesis. An alarming problem in clinics is the development of resistances against this azole, especially during long-term treatment of patients. Well-known resistance mechanisms include mutations in the zinc cluster transcription factors (ZnTFs) Mrr1 and Tac1, which cause an overexpression of efflux pump genes, and Upc2, which results in an overexpression of the drug target. C. albicans strains with such gain-of-function mutations (GOF) have an in

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Chen, Yen-Ning, and 陳妍寧. "Development of flucytosine resistance in Candida tropicalis is caused by nonsense mutations in FCY2, followed by loss of heterozygosity." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/05714440604607717182.

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碩士<br>國立交通大學<br>分子醫學與生物工程研究所<br>98<br>Candida tropicalis, a diploid yeast, has been regarded as one of the most invasive and prevalent species of non-albicans Candida. Previous work has shown that 31.25% (30/96) of flucytosine (5FC) susceptible clinical isolates could generate drug resistant progeny. It has revealed that there was an association between a set of polymorphic nucleotides in FCY2 (encoding a cytosine transporter) and the observed drug resistant phenotype. In this study, the molecular mechanisms of 5FC resistance in these C. tropicalis have been further investigated. First of all,

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Chen, Hsueh-Fen, and 陳雪芬. "Studying Candida albicans Sfp1 in the Regulation of Biofilm Formation and Drug Resistance." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/nu68v8.

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博士<br>國立清華大學<br>分子與細胞生物研究所<br>104<br>Candida albicans is a major human fungal pathogen. One of the important features of C. albicans pathogenicity is the ability to form biofilms on mucosal surfaces and indwelling medical devices. Biofilm formation involves complex processes in C. albicans, including cell adhesion, filamentous growth, extracellular matrix secretion and cell dispersion. In this work, we characterized the role of the transcription factor Sfp1, particularly with respect to its function in the regulation of biofilm formation. The deletion of the SFP1 gene enhanced cell adhesion an

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Figueiredo, Matilde de Almeida. "The role of mistranslation in the acquisition of antifungal resistance." Master's thesis, 2019. http://hdl.handle.net/10773/28410.

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Translation of mRNA by the ribosome is a high-fidelity biological process whose error rates range from 10-3 to 10-4 in eukaryotic cells. Such low error rate generalized the idea that mistranslation is a nuisance to the cell without biological relevance. However, recent studies show that translational errors are regulated and play important roles in adaptation to stress situations. Candida albicans, the most prevalent human fungal pathogen, mistranslates naturally at high level in a dynamic way. Exposure of C. albicans to different growth conditions increases mistranslation levels which results

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Huang, Mian. "In Vitro Evolutionary Dynamics of C. albicans during Adaptation to Fluocnazole." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11548.

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Many drug-resistant mechanisms in Candida albicans (C. albicans), a clinical important fungal pathogen, have been well characterized. However, few studies investigated the emergence of drug resistance from the evolutionary perspective and little is known about the evolutionary trajectories during the adaptation to the drug. Here, we examined the evolutionary dynamics of C. albicans both in the presence and absence of fluconazole, a first line drug, using the visualizing evolution in real-time (VERT) method. Evolutionary dynamics of replicate C. albicans populations, either in the presence o

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Hsiao, Ting-Yin, and 蕭婷尹. "Linking morpgology/virulence and drug resistance via ergosterol biosynthesis and glycolysis pathways in Candida albicans." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/71958982787746946497.

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碩士<br>國立交通大學<br>生化工程研究所<br>94<br>Candida albicans is an opportunistic fungal pathogen in humans. It has been reported that the cph1/cph1 efg1/efg1 double mutant of C. albicans is defective in filamentous growth and is also avirulent in a mouse model. The ability of C. albicans to switch between a yeast form and a filamentous form has been implicated in its virulence. Previous comparative genomics studies have profiled the expression differences between the wide-type and the cph1/cph1 efg1/efg1 double mutant strains by the method of Suppression Subtractive Hybridization (SSH) and sequence analy

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Mendonça, Catarina Ribeiro. "Epidemiological survey of the pattern of colonization and infection caused by species of the Candida genus in Hospitals of the Lisbon area: emphasis on azole resistance and emergence of non-conventional species." Master's thesis, 2019. http://hdl.handle.net/10451/43456.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019<br>Até hoje já foram conduzidos em Portugal alguns estudos epidemiológicos focados na caracterização da candidemia invasiva, no entanto, pouco se sabe sobre qual o padrão de colonização das espécies do género Candida em nichos considerados não estéreis onde estas espécies podem existir como comensais. Estudos recentes têm demonstrado o papel importante que as populações comensais podem desenvolver enquanto focos de infeção invasiva. Nesse sentido, neste trabalho foi analisada a fre

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Chen, Yu Wen, and 陳裕文. "The small GTPase Rhb1 modulates cell wall integrity, biofilm formation and drug resistance in Candida albicans." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/76266336149770693556.

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碩士<br>國立清華大學<br>分子與細胞生物研究所<br>104<br>Candida albicans is an important fungal pathogen of humans. It is generally harmless in healthy individuals, but can cause invasive and life-threatening infections particularly in immunocompromised patients. The first step for C. albicans to establish infection is to adhere the surface of host cells. Moreover, C. albicans adhesion is also the key step of biofilm formation on mucosal surfaces and medical devices. The cell wall of C. albicans plays a critical role in cell adhesion and pathogen-host interaction, and is essential for C. albicans to withstand en

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Li, Shu-Ping, and 李淑萍. "The involvement of the glycolytic pathway gene, CaGPM1, in the morphology and drug resistance in Candida albicans." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/29721586924902408713.

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碩士<br>國立交通大學<br>生物科技系所<br>97<br>Candida albicans is an important pathogen of humans. It has been reported that the cph1/cph1 efg1/efg1 double mutant strain of C.albicans is defective in filamentous growth and is also avirulent in a mouse model. The ability of C. albicans to switch between a yeast form and a filamentous form has been implicated in its virulence. Previous comparative genomics studies have profiled the expression differences between the wide-type and the cph1/cph1 efg1/efg1 double mutant strains. Genes isolated from these experiments may be involved in virulence and / or filament

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Costa, Inês Margarida Vieira Marques da. "Role of the Candida glabrata Mediator complex subunit Pgd1 in azole drug resistance and susceptibility: a transcriptomics approach." Master's thesis, 2020. http://hdl.handle.net/10451/47649.

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Tese de mestrado em Microbiologia Aplicada, Universidade de Lisboa, Faculdade de Ciências, 2021<br>Espécies do género Candida fazem parte da microbiota do trato gastrointestinal humano, sendo capazes de colonizar também a pele e superfícies mucosas do corpo humano, como organismos comensais. No entanto são a causa mais comum de infeções por fungos oportunistas no mundo, causando candidíases superficiais e sistémicas. As candidíases sistémicas têm uma taxa de mortalidade altíssima, especialmente quando associadas a pacientes imunocomprometidos. A espécie do género Candida mais frequentemente is

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Wu, Chia-Chen, and 吳佳真. "Loss of heterozygosity contributes to the resistance to 5-flucytosine in Candida tropicalis and the study of identifying the crucial amino acids in the activation domain of CaNDT80." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/01843871816822773244.

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碩士<br>國立交通大學<br>生物科技系所<br>97<br>In the laboratory, C. tropicalis clinical isolates were selected for derivatives resistant to 5-flucytosine (5-FC). Researchers have previously shown that disruption of the function of any protein involved in pyrimidine biosynthetic pathway or regulation could contribute to 5-FC resistance. Accordingly, four genes , FCY1, FCY2, FUR1 and URA3 involved in pyrimidine biosynthetic pathway was sequenced. The result revealed that some strains were heterozygous in FCY2 encoding purine cytosine permease (PCP), whereas their drug-resistant derived strains were homozygous

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dos, Santos Abrantes Pedro Miguel. "Characterization of candida species isolated from the oral mucosa of HIV-positive African patients." 2013. http://hdl.handle.net/11394/3498.

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Philosophiae Doctor - PhD<br>One of the most common HIV-associated opportunistic infections is candidiasis, caused by Candida albicans or other Candida species. In immune suppressed subjects, this commensal organism can cause an increase in patient morbidity and mortality due to oropharyngeal or systemic dissemination. Limited information exists on the prevalence and antifungal susceptibility of Candida species in the African continent, the most HIV-affected region globally and home to new and emerging drug resistant Candida species. The mechanisms of Candida drug resistance in the African con

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LaFayette, Shantelle. "PKC Signaling Regulates Drug Resistance of Candida albicans and Saccharomyces cerevisiae via Divergent Circuitry Composed of the MAPK Cascade, Calcineurin and Hsp90." Thesis, 2010. http://hdl.handle.net/1807/25741.

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Treating fungal infections is challenging due to the emergence of drug resistance and the limited number of clinically useful antifungal drugs. To improve clinical outcome it will be necessary to develop new antifungal drugs with different mechanisms of action and to discover drugs that improve the fungicidal activity of current antifungals. This study reveals a new role for fungal protein kinase C (PKC) signaling in resistance to drugs targeting the ergosterol biosynthesis pathway in the pathogenic fungus, Candida albicans, and the model yeast, Saccharomyces cerevisiae. PKC signaling enabled

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Wang, Jang-Shiun, and 王彰勳. "PartI: Characterization of the functions of 1, 3-b-glucanase-like protein CaIpf885p in Candida albicansPartII: Elucidation of the functions of the DNA binding domain of CaNdt80p in drug resistance in Candida albicans." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/57451629938379953398.

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博士<br>國防醫學院<br>生命科學研究所<br>95<br>PartI: Candida albicans is an opportunistic pathogen causing high mortality in immuno-compromised patient. The more and more antifungal drug resistant strains were isolated from nosocomial infections. Today, the development of new drugs with low side effects is the important issue. The cell wall is a good target for antifungal drug because the mammalian does not have such organelle. Thus, enzymes having the function to modify the components of cell wall are good target for designing new drugs. In C. albicans, I found at least 11 genes potentially encoding glucan

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Znaidi, Sadri. "Identification des réseaux transcriptionnnels de résistance aux antifongiques chez Candida albicans." Thèse, 2009. http://hdl.handle.net/1866/3560.

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Plusieurs souches cliniques de Candida albicans résistantes aux médicaments antifongiques azolés surexpriment des gènes encodant des effecteurs de la résistance appartenant à deux classes fonctionnelles : i) des transporteurs expulsant les azoles, CDR1, CDR2 et MDR1 et ii) la cible des azoles 14-lanostérol déméthylase encodée par ERG11. La surexpression de ces gènes est due à la sélection de mutations activatrices dans des facteurs de transcription à doigts de zinc de la famille zinc cluster (Zn2Cys6) qui contrôlent leur expression : Tac1p (Transcriptional activator of CDR genes 1) contrôlant

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