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Relevant bibliographies by topics / Drug Resistance Floxuridine Gene Therapy

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Academic literature on the topic 'Drug Resistance Floxuridine Gene Therapy'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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Journal articles on the topic "Drug Resistance Floxuridine Gene Therapy"

1

Zaboikin, M., N. Srinivasakumar, and F. Schuening. "Gene therapy with drug resistance genes." Cancer Gene Therapy 13, no. 4 (2005): 335–45. http://dx.doi.org/10.1038/sj.cgt.7700912.

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Banerjee, Debabrata, Shi Cheng Zhao, Ming-Xia Li, Barry I. Schweitzer, Shin Mineishi, and Joseph R. Bertino. "Gene therapy utilizing drug resistance genes: A review." Stem Cells 12, no. 4 (1994): 378–85. http://dx.doi.org/10.1002/stem.5530120404.

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GOTTESMAN, MICHAEL M., URSULA A. GERMANN, IVAN AKSENTIJEVICH, YOSHIKAZU SUGIMOTO, CAROL O. CARDARELLI, and IRA PASTAN. "Gene Transfer of Drug Resistance Genes Implications for Cancer Therapy." Annals of the New York Academy of Sciences 716, no. 1 Gene Therapy (1994): 126–43. http://dx.doi.org/10.1111/j.1749-6632.1994.tb21708.x.

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4

Naghizadeh, Sanaz, Behzad Mansoori, Ali Mohammadi, Ebrahim Sakhinia, and Behzad Baradaran. "Gene Silencing Strategies in Cancer Therapy: An Update for Drug Resistance." Current Medicinal Chemistry 26, no. 34 (2019): 6282–303. http://dx.doi.org/10.2174/0929867325666180403141554.

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RNAi, post-transcriptional gene silencing mechanism, could be considered as one of the most important breakthroughs and rapidly growing fields in science. Researchers are trying to use this discovery in the treatment of various diseases and cancer is one of them although there are multiple treatment procedures for treatment-resistant cancers, eradication of resistance remain as an unsolvable problem yet. The current review summarizes both transcriptional and post-transcriptional gene silencing mechanisms, and highlights mechanisms leading to drug-resistance such as, drug efflux, drug inactivat

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Gerson, Stanton L. "Selection without harm: drug resistance gene therapy hits the big time." Blood 105, no. 3 (2005): 914. http://dx.doi.org/10.1182/blood-2004-11-4251.

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Budak-Alpdogan, Tulin, Debabrata Banerjee, and Joseph R. Bertino. "Hematopoietic stem cell gene therapy with drug resistance genes: an update." Cancer Gene Therapy 12, no. 11 (2005): 849–63. http://dx.doi.org/10.1038/sj.cgt.7700866.

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Schmitt, Michael W., Justin R. Pritchard, Graeme Hodgson, et al. "Emergence of Sub-Clonal Drug Resistance Mutations during CML Therapy." Blood 126, no. 23 (2015): 478. http://dx.doi.org/10.1182/blood.v126.23.478.478.

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Abstract Tyrosine kinase inhibitors (TKIÕs) vastly improve survival in chronic myeloid leukemia (CML). However resistance is a common occurrence, and is most frequently mediated by point mutations in the Abl kinase. There have been conflicting reports regarding the frequency of resistance mutations in the Abl kinase at the time of CML diagnosis, with some studies indicating that a large number of resistance mutations are pre-existing in many patients. However, a high burden of pre-existing resistance mutations is seemingly at odds with the ability of TKIÕs to initially control CML for months t

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8

Bank, Arthur, Maureen Ward, Christine Richardson, Patricia Pioli, and Charles Hesdorffer. "Transfer and expression of the human multiple drug resistance gene as potential human gene therapy." Cytotechnology 18, no. 1-2 (1995): 119–24. http://dx.doi.org/10.1007/bf00744327.

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9

Machado, Susana, Andreia Silva, Ana Luísa De Sousa-Coelho, et al. "Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance." Cancers 12, no. 12 (2020): 3689. http://dx.doi.org/10.3390/cancers12123689.

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Therapy resistance is responsible for most relapses in patients with cancer and is the major challenge to improving the clinical outcome. The pseudokinase Tribbles homologue 2 (TRIB2) has been characterized as an important driver of resistance to several anti-cancer drugs, including the dual ATP-competitive PI3K and mTOR inhibitor dactolisib (BEZ235). TRIB2 promotes AKT activity, leading to the inactivation of FOXO transcription factors, which are known to mediate the cell response to antitumor drugs. To characterize the downstream events of TRIB2 activity, we analyzed the gene expression prof

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10

Franco, Marina S., and Mônica C. Oliveira. "Liposomes Co- encapsulating Anticancer Drugs in Synergistic Ratios as an Approach to Promote Increased Efficacy and Greater Safety." Anti-Cancer Agents in Medicinal Chemistry 19, no. 1 (2019): 17–28. http://dx.doi.org/10.2174/1871520618666180420170124.

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The era of chemotherapy began in the 1940s, but it was in the 1960s that it was seen as really promising when the first patients with childhood acute lymphoblastic leukemia were cured with combination chemotherapy. Today, it is known that due to resistance to single agents, combination therapy is essential for tumor eradication and cure. In the last decade, studies have shown that anticancer drug combinations can act synergistically or antagonistically against tumor cells in vitro, depending on the ratios of the individual drugs forming the combination. From this observation and facing the pos

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Dissertations / Theses on the topic "Drug Resistance Floxuridine Gene Therapy"

1

Landis, Daniel Marc. "In vitro evolution of 5-fluorouracil resistant thymidylate synthases for cancer gene therapy /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6329.

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Sharma, Divya. "Drug Delivery Systems for Treatment of Diabetes Mellitus." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31745.

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Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic episodes associated with fatal complications in type-1 diabetes patients. The purpose of this study was to develop a thermosensitive copolymer-based in situ depot forming delivery system to provide controlled release of insulin for extended duration following a single subcutaneous injection, closely mimicking physiological basal insulin requirement. Size and nature of the incorporated therapeutic were observed to affect the release profile of insulin. Modification with zinc and chitosan preserved ther

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Salazar, Marcela d'Alincourt. "Genomic Effects of Hormonal Adjuvant Therapies that Could Support the Emergence of Drug Resistance in Breast Cancer." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1280929084.

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4

Maseko, Phiri Thabiso. "Predictive value of gene mutations as a diagnostic tool for ART resistance in a Zambian population." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71845.

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Thesis (MSc)--Stellenbosch University, 2012.<br>Background: While Selection of reverse transcriptase (RT) mutation has been reported frequently, protease (PR) mutations on antiretroviral therapy (ART) including boosted Protease inhibitor (PI) have not been reported as much in Zambia. Affordable in-house genotyping assays can been used to expand the number of patients receiving drug resistance geno-typing, which can aid in determining prevalence of RT/PI emerging mutations. Methods: A previously published drug resistance genotyping assay was modified and used to genotype RT and PR genes.

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Ruiz, Jorge Luis Maria. "Caracterização de uma nanopartícula lipídica semelhante à LDL (LDE) como vetor para RNA de interferência." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-14062011-154226/.

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As nanopartículas são consideradas promissores vetores para a liberação eficaz e segura de ácidos nucléicos para tipos específicos de célula ou tecido, proporcionando uma alternativa aos vetores virais para terapia gênica. No entanto, com a maioria destes sistemas não torna possível a entrega de oligonucleotídeos nas células in vivo de forma especifica. O uso de uma nanoemulsão funcionalmente semelhante à lipoproteina de baixa densidade poderia resolver esse problema, pois esta particula é capaz de direcionar o transporte das moléculas para a internalização celular através de receptores de LDL

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6

Filho, Mateus de Camargo Barros. "Expressão de grupos de genes como marcadores moleculares preditivos de resposta à quimioterapia neoadjuvante com doxorrubicina e ciclofosfamida em pacientes com câncer de mama." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-08092009-154034/.

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Pacientes com câncer de mama localmente avançado são submetidas à quimioterapia neoadjuvante na tentativa de reduzir a dimensão do tumor e aumentar a possibilidade da realização de uma cirurgia conservadora. Nosso grupo identificou previamente através da tecnologia de cDNA microarray, trios de genes, incluindo BZRP, CLPTM1, MTSS1, NOTCH1, NUP210, PRSS11, RPL37A, SMYD2 e XLHSRF-1, cuja expressão era capaz de predizer a resposta à quimioterapia neoadjuvante com doxorrubicina e ciclofosfamida em pacientes com câncer de mama. No presente estudo, avaliamos se a expressão destes genes é reprodutível

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Tsai, Ming-Huan, and 蔡明寰. "(I) Gene Therapy and (II) Drug Resistance in Bladder Cancer." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/82344981226279929751.

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碩士<br>國立成功大學<br>生物化學研究所<br>88<br>I. Gene Therapy in Bladder Cancer Combination of surgery, chemotherapy and radiotherapy is the standard therapy for invasive bladder cancer, but the five-year recurrence rate is still discouraging (>50%). Therefore, it is important to develop other effective therapies and gene therapy is a potential candidate. Our laboratory has established 3 tumor vaccines, MBT-2-IL-2, MBT-2-IL-4, MBT-2-GM-CSF for MBT-2 cells and C3H/HeNCrj mice animal model. Previous study indicated that MBT-2-IL-2 provide better therapeutic efficacy: tumor formation ra

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"Role of lethal giant larvae homolog 1 gene in drug resistance of pancreatic cancer cells." 2014. http://library.cuhk.edu.hk/record=b6116228.

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背景和目的：胰腺導管腺癌（簡稱胰腺癌）是世界範圍內惡性程度最高的癌癥之一，目前它的5 年生存率不到5%。大部分的病人在診斷初期就已經發展到了局部浸潤或遠處轉移的階段，因此失去了根治性手術切除的机会。輔助性化療對於胰腺癌病人來說是一個首選的治療方案，但是目前只有一小部分病人對化療藥物有良好的反應，而臨床化療失敗常與腫瘤細胞對化療藥物產生耐藥有關。吉西他濱是目前臨床上常用的一線抗癌藥物，但是它的耐藥現象在胰腺癌病人中廣泛存在，也是阻礙其臨床應用的主要原因之一。盡管已經有很多研究致力於揭示吉西他濱在胰腺癌細胞中的耐藥機理，目前臨床上仍然沒有有效的方法應對吉西他濱耐藥。我們的研究主要是為了探討一些以前沒有报道過的參與吉西他濱耐藥機理的基因，借此揭示胰腺癌細胞的吉西他濱耐藥的深層機制，為臨床上的治療提供理論依據。<br>實驗方法：我們實驗室之前在胰腺癌細胞株Capan2 中用全基因組RNAi篩選的方法確定LLGL1 作為抑癌基因能增強吉西他濱在胰腺癌細胞中的細胞毒性。我們隨後用體外細胞毒性分析實驗和皮下腫瘤動物模型來驗證LLGL1 是否能增強吉西他濱的細胞毒性，用蘇木素-伊紅染色和原味末端轉移酶標記技術分析抑制LLGL1 的表達是否會影響吉西他濱誘導的細胞雕亡反應。我們還應用微陣列分析技術進一步探尋LLGL1 的下遊靶蛋白，用實時定量PCR(qRT-PCR) 、蛋白印跡法（western b

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Books on the topic "Drug Resistance Floxuridine Gene Therapy"

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Bertino, J. R., ed. Marrow Protection: Transduction of Hematopoietic Cells with Drug Resistance Genes. Karger, 1999.

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2

I, Skarlatos Sonia, Velletri Paul August, Morris Mariana 1947-, Davies P. D. O, and New York Academy of Sciences., eds. New vistas in therapeutics: From drug design to gene therapy. New York Academy of Sciences, 2001.

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3

New Vistas in Therapeutics/Drug-Resistant Tuberculosis: From Drug Design to Gene Therapy : From Molecules to Macro-Economics (Annals of the New York Academy of Sciences). 2nd ed. New York Academy of Sciences, 2002.

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4

Thursfield, Rebecca, Chris Orchard, Rosanna Featherstone, and Jane C. Davies. Future treatments. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0013.

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There are only a relatively limited armoury of drugs, the majority of which are aimed at downstream symptoms of cystic fibrosis. Therapies targeting the basic defect in CF as well as continued availability of more conventional drugs are required. Progress in gene therapy has been limited by the significant barriers to gene transfer of the CF lung, but the UK is hosting a large repeated dose trial of nebulized non-viral gene therapy designed around clinically meaningful outcomes. The UK CF Gene Therapy Consortium is also seeking to develop a promising modified lentiviral approach, although this

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Book chapters on the topic "Drug Resistance Floxuridine Gene Therapy"

1

Takebe, N., S. C. Zhao, D. Banerjee, and J. R. Bertino. "Protection of Hematopoietic Progenitor Cells from Chemotherapy Toxicity by Transfer of Drug Resistance Genes." In Gene Therapy. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-03577-1_8.

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2

Bank, Arthur, Maureen Ward, Christine Richardson, Patricia Pioli, and Charles Hesdorffer. "Transfer and expression of the human multiple drug resistance gene as potential human gene therapy." In Animal Cell Technology: Developments Towards the 21st Century. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0437-1_151.

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"Section IV. Drug Resistance and Metabolism Gene Therapy." In Gene Therapy of Cancer. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-394295-1.00056-1.

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4

KOÇ, OMER N., STEVEN P. ZIELSKE, JUSTIN C. ROTH, JANE S. REESE, and STANTON L. GERSON. "Transfer of Drug-Resistance Genes into Hematopoietic Progenitors." In Gene Therapy of Cancer. Elsevier, 2002. http://dx.doi.org/10.1016/b978-012437551-2/50022-7.

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5

Huber, Brian E. "Genetically engineering drug sensitivity and drug resistance for the treatment of cancer." In Gene Therapy in the Treatment of Cancer. Cambridge University Press, 1998. http://dx.doi.org/10.1017/cbo9780511663352.005.

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Rani, Madhu, Sumit Kumar, and M. Moshahid Alam Rizvi. "Role of Stem Cells in Cancer Therapeutics." In Handbook of Research on Advancements in Cancer Therapeutics. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-6530-8.ch016.

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Stem cells are pluripotent cells having capacity of self-renewal and produce various types of mature cells. Cancer stem cells are known to be responsible for drug resistance and tumor relapse, yet stem cells offer multiple avenues to treat same. Stem cells have been employed for treating of blood and immune systems damaged during chemotherapy and radiotherapy. Stem cell transplantation is emerged as critical therapy in cancer treatment, yet other potential applications of stem cells in cancer treatment are largely unexplored or underutilized. Recently, stem cells reengineered express different cytotoxic agents. It has shown to cause tumor regression and enhance the animal survival in preclinical studies. Stem cell therapy can be also employed for targeted drug delivery, gene delivery, and even used as virus to target cancer cell. In recent years, research is devoted on stem cells worldwide for new and newer application. Although the field of stem cells is nascent and raises many ethical concerns, scientific responsibilities, and future challenges, scientific community are still hopeful and filled with optimism. Currently, stem cell therapy represents the beginning of the new era in cancer treatment and giving a ray of hope to clinicians and also patients who are suffering from untreatable diseases and desperately looking for new therapies. In the present chapter, the authors mainly shed light on potential applications of stem cells to treat cancer. At the end, they also discussed the factor influencing stem cell therapies and current challenges in stem cell therapy.

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Conference papers on the topic "Drug Resistance Floxuridine Gene Therapy"

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Sakai, Ryo, Kai Xu, Bingliang Fang, Jack A. Roth, and Lin Ji. "Abstract 3634: Overcoming drug resistance to EGFR-tyrosine kinase inhibitors by FUS1 or FHIT-gene therapy in human lung cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3634.

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2

Okon, Imoh S., Kathleen A. Coughlan, and Ming-Hui Zou. "Abstract B24: Attenuated expression of a novel mitochondrial and metabolic gene contributes to acquired gefitinib resistance in lung tumors." In Abstracts: AACR Precision Medicine Series: Drug Sensitivity and Resistance: Improving Cancer Therapy; June 18-21, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.pms14-b24.

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Li, Jianbo, and Hao Lin. "The Effect of Electrical Conductivity on Pore Resistance and Electroporation." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67773.

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Electroporation refers to the permeabilization of the cell membrane with one or multiple electric pulses. The reversible form of electroporation is widely applied for drug delivery, gene and cancer therapy, and stem cell research, among others; the irreversible form of electroporation is being explored for cancer treatment in a drug-free manner. In this work, an electroporation model is developed with particular focus on the prediction of pore resistance. The resulting formulation computes pore resistance as a function of pore size, and intracellular and extracellular conductivities, and avoid

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