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Journal articles on the topic 'Drug-resistant infections'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Patrick, Christian C. "Drug-resistant staphylococcal infections." Seminars in Pediatric Infectious Diseases 7, no. 3 (1996): 182–86. http://dx.doi.org/10.1016/s1045-1870(96)80006-9.

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2

Woods, Charles R., and Laurence B. Givner. "Drug-resistant meningococcal infections." Seminars in Pediatric Infectious Diseases 7, no. 3 (1996): 204–11. http://dx.doi.org/10.1016/s1045-1870(96)80008-2.

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3

Hoppe, B. "Control of infections caused by drug-resistant organisms in critical care." American Journal of Critical Care 6, no. 2 (1997): 141–44. http://dx.doi.org/10.4037/ajcc1997.6.2.141.

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The emergence of antibiotic-resistant pathogens has been an ongoing concern of infection-control and infectious disease practitioners. Infections caused by these organisms increase costs and may result in poorer outcomes for patients. Efforts to contain the problem of infections caused by drug-resistant organisms have two objectives: to optimize antibiotic use and to prevent transmission through effective infection-control practices.

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4

Weese, J. S. "A review of multidrug resistant surgical site infections." Veterinary and Comparative Orthopaedics and Traumatology 21, no. 01 (2008): 1–7. http://dx.doi.org/10.3415/vcot-07-11-0106.

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SummarySurgical site infections caused by bacteria that are resistant to multiple classes of antimicrobials are an important and increasing problem in veterinary medicine. Organisms such as methicillin-resistant staphylococci, extended spectrum beta-lactamase Enterobacteriaceae and multi-drug resistant Enterococcus, Acinetobacter and Pseudomonas spp. are among the current concerns; however, the emergence and dissemination of other multi-drug resistant organisms will likely follow. Despite the negative connotations that are associated with multi-drug resistant infections, most infections are po

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5

Potera, Carol. "Tackling Drug-Resistant Bacterial Infections." Genetic Engineering & Biotechnology News 32, no. 8 (2012): 8–10. http://dx.doi.org/10.1089/gen.32.8.02.

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6

Dorrell, Sharon. "Overcoming drug-resistant yeast infections." Drug Discovery Today 7, no. 6 (2002): 332–33. http://dx.doi.org/10.1016/s1359-6446(02)02221-3.

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7

Jacobs, Richard F. "Introduction: Drug-resistant bacterial infections." Seminars in Pediatric Infectious Diseases 7, no. 3 (1996): 156. http://dx.doi.org/10.1016/s1045-1870(96)80002-1.

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8

Sanford, Jay P., and Edward C. Rosenow. "Combating Drug-Resistant Pneumococcal Infections." Hospital Practice 29, no. 10 (1994): 31–37. http://dx.doi.org/10.1080/21548331.1994.11443087.

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9

Shrestha, Lok Bahadur, Narayan Raj Bhattarai, and Basudha Khanal. "Bacteriological Profile and Antimicrobial Susceptibility Pattern among Isolates Obtained From Body Fluids." Journal of Nepal Health Research Council 17, no. 2 (2019): 173–77. http://dx.doi.org/10.33314/jnhrc.v0i0.1656.

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Background: Infections of the sterile body sites, when occurs typically have greater clinical urgency and these infections could be life threatening. For the appropriate management of patient, early detection and identification of organism is crucial. Hence, the present study was designed to evaluate the prevalence, organism profile and antimicrobial susceptibility pattern of isolates obtained from infection of body fluids.Methods: Laboratory and clinical records of all the sterile body fluid except blood and cerebrospinal fluid submitted to the Department of Microbiology, B. P. Koirala Instit

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10

Nastri, Bianca Maria, Pasquale Pagliano, Carla Zannella, et al. "HIV and Drug-Resistant Subtypes." Microorganisms 11, no. 1 (2023): 221. http://dx.doi.org/10.3390/microorganisms11010221.

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Acquired Immunodeficiency Syndrome (AIDS) is a human viral infectious disease caused by the positive-sense single-stranded (ss) RNA Human Immunodeficiency Virus (HIV) (Retroviridae family, Ortervirales order). HIV-1 can be distinguished into various worldwide spread groups and subtypes. HIV-2 also causes human immunodeficiency, which develops slowly and tends to be less aggressive. HIV-2 only partially homologates to HIV-1 despite the similar derivation. Antiretroviral therapy (ART) is the treatment approved to control HIV infection, based on multiple antiretroviral drugs that belong to differ

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11

Gkartziou, Foteini, Nikolaos Giormezis, Iris Spiliopoulou, and Sophia G. Antimisiaris. "Nanobiosystems for Antimicrobial Drug-Resistant Infections." Nanomaterials 11, no. 5 (2021): 1075. http://dx.doi.org/10.3390/nano11051075.

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The worldwide increased bacterial resistance toward antimicrobial therapeutics has led investigators to search for new therapeutic options. Some of the options currently exploited to treat drug-resistant infections include drug-associated nanosystems. Additionally, the use of bacteriophages alone or in combination with drugs has been recently revisited; some studies utilizing nanosystems for bacteriophage delivery have been already reported. In this review article, we focus on nine pathogens that are the leading antimicrobial drug-resistant organisms, causing difficult-to-treat infections. For

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12

Livermore, David M. "Management of Multiple Drug-Resistant Infections." Journal of Antimicrobial Chemotherapy 54, no. 6 (2004): 1162. http://dx.doi.org/10.1093/jac/dkh466.

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13

Rifkin, Gary D. "Management of Multiple Drug-Resistant Infections." Annals of Internal Medicine 140, no. 12 (2004): 1064. http://dx.doi.org/10.7326/0003-4819-140-12-200406150-00032.

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14

Kuehn, Bridget. "Drug-Resistant Infections from Raw Milk." JAMA 319, no. 12 (2018): 1191. http://dx.doi.org/10.1001/jama.2018.2363.

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15

Minami, Masaaki, Ryoko Sakakibara, and Shunsuke Akahori. "SG-APSIC1155: Drug susceptibility patterns of fulminant group G Streptococcus (GGS) infection as a re-emerging infectious disease in Japan." Antimicrobial Stewardship & Healthcare Epidemiology 3, S1 (2023): s10. http://dx.doi.org/10.1017/ash.2023.32.

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Objectives: Severe streptococcal infections are invasive, re-emerging infections that rapidly worsen and lead to death. Not only group A Streptococcus (GAS) but also group g Streptococcus (GGS) are the causative agents of this infection. Moreover, GGS produces hemolytic toxins, proteolytic toxins, and other toxins like GAS. Furthermore, drug-resistant Streptococcus spp, like other pathogenic bacteria, are on the rise worldwide. However, drug resistance has not been studied extensively in invasive GGS. Therefore, we investigated the drug susceptibility of GGS clinical isolates that are closely

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16

Singh, Neha, Nikita Sherwani, and Khushboo Bhange. "The mounting hazard of drug-resistant infections, its impact and global action." Journal of Bacteriology & Mycology: Open Access 13, no. 2 (2025): 71–75. https://doi.org/10.15406/jbmoa.2025.13.00401.

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The rise of drug-resistant infections poses a significant global health threat, undermining decades of medical progress. Antimicrobial resistance (AMR) occurs when bacteria, viruses, fungi, and parasites evolve to withstand the effects of drugs designed to kill them, rendering treatments ineffective. This phenomenon is primarily driven by the overuse and misuse of antibiotics in human medicine, agriculture, and animal husbandry. Poor infection control, inadequate sanitation, and limited access to new antibiotics further exacerbate the crisis. Drug-resistant infections complicate routine medica

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17

Kabir, Md Saiful, Wazeda Begum, Md Maruf Ur Rahman, and Nehal Warish. "A case report of drug resistant Tinea corporis." Journal of Dhaka National Medical College & Hospital 24, no. 1 (2018): 44–47. https://doi.org/10.3329/jdnmch.v24i1.80058.

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Superfecial fungal infections of the skin are a major health problem and associated with morbidity due to chronic itching and inflammation of skin. Tinea corporis is known as ringworm, a superficial fungal infection (dermatophytosis) of the arms and legs, especially on glabrous skin. Treatment includes systemic and topical antifungals with variable duration depending upon the site of infection and the antifungal chosen. Choosing the right treatment is not always simple because of the possibility of drug interactions and drug resistance. Recently Clinical failure and relapses have been observed

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18

Karum, Ataa Elias, Soha Jassim Mohammed, Sanaa Adnan Abdul Hussein, Israa Saleh Ahmed, and Marwa Muhammad Odeh. "PATHOPHYSIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AND DRUG RESISTANCE." European Journal of Medical Genetics and Clinical Biology 1, no. 4 (2024): 71–77. http://dx.doi.org/10.61796/jmgcb.v1i4.407.

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Methicillin- resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens of community and hospital acquired bacterial infections. MRSA can lead to diverse infection such as bacteremia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital- acquired infections . As well as genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. They are also becoming increasingly multi-drug resistant

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19

Ghazaei, Ciamak. "Upcoming Multi-drug-Resistant and Extensively Drug-Resistant Bacteria." Research in Molecular medicine 10, no. 2 (2022): 0. http://dx.doi.org/10.32598/rmm.10.2.820.7.

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Multi-drug-resistant (MDR) and extensively drug-resistant (XDR) bacteria are becoming a serious global health issue, which may soon become untreatable by clinicians. Since the invention of antibiotics, inappropriate consumption, non-prescribed drugs, overuse, and hoarding have caused the rapid emergence of MDR and XDR bacteria. The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Enterobacter spp.) cause many nosocomial infections and thus escape the biocidal action of the antibiotic. Gram-positive and Gr

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20

WILLIAM, S., S. BOTROS, M. ISMAIL, A. FARGHALLY, T. A. DAY, and J. L. BENNETT. "Praziquantel-induced tegumental damage in vitro is diminished in schistosomes derived from praziquantel-resistant infections." Parasitology 122, no. 1 (2001): 63–66. http://dx.doi.org/10.1017/s0031182000007137.

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The aggressive use of praziquantel to combat schistosomiasis in Egpyt raises concern about the possible emergence of resistance. Eggs from Egyptian patients with praziquantel-resistant infections (not cured by 3 doses of praziquantel) have been used to establish infection-specific schistosome isolates in mice. The response of these worms to the drug was observed in vitro, in order to determine if the isolates obtained from these resistant infections were, in fact, less responsive to praziquantel. One of the hallmark effects of praziquantel on schistosomes in vitro is a disruption of the worm's

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21

Rani, Kirti. "Precipitated probe on aetiology of MRSA skin infections: a global concern." Journal of Bacteriology & Mycology: Open Access 12, no. 3 (2024): 133–35. https://doi.org/10.15406/jbmoa.2024.12.00387.

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MRSA (Methicillin-Resistant Staphylococcus aureus) infection is the type of communicable skin disease caused by staph bacteria, named Staphylococcus aureus which become antibiotic resistant while treating patients. Staph bacteria are found to present ubiquitously in the skin and mucous membranes especially in nasal area in human. However, these pathogenic staph bacteria cause lethal skin diseases due to getting antibiotic resistant when enter in blood streams/ internal tissues. Previous studies based on antibiotic susceptibilities, it was confirmed that methicillin resistance in Staphylococcus

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22

Kanth, Shreya, Akshatha Nagaraja, and Yashoda Malgar Puttaiahgowda. "Polymeric approach to combat drug-resistant methicillin-resistant Staphylococcus aureus." Journal of Materials Science 56, no. 12 (2021): 7265–85. http://dx.doi.org/10.1007/s10853-021-05776-7.

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Abstract The current global death rate has threatened humans due to increase in deadly unknown infections caused by pathogenic microorganisms. On the contrary, the emergence of multidrug-resistant bacteria is also increasing which is leading to elevated lethality rate worldwide. Development of drug-resistant bacteria has become one of the daunting global challenges due to failure in approaching to combat against them. Methicillin-resistant Staphylococcus aureus (MRSA) is one of those drug-resistant bacteria which has led to increase in global mortality rate causing various lethal infections. P

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23

Moghadas, Seyed M. "Management of drug resistance in the population: influenza as a case study." Proceedings of the Royal Society B: Biological Sciences 275, no. 1639 (2008): 1163–69. http://dx.doi.org/10.1098/rspb.2008.0016.

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The rise of drug resistance remains a major impediment to the treatment of some diseases caused by fast-evolving pathogens that undergo genetic mutations. Models describing the within-host infectious dynamics suggest that the resistance is unlikely to emerge if the pathogen-specific immune responses are maintained above a certain threshold during therapy. However, emergence of resistance in the population involves both within-host and between-host infection mechanisms. Here, we employ a mathematical model to identify an effective treatment strategy for the management of drug resistance in the

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24

Shen, Mingwang, Yanni Xiao, Libin Rong, Lauren Ancel Meyers, and Steven E. Bellan. "Early antiretroviral therapy and potent second-line drugs could decrease HIV incidence of drug resistance." Proceedings of the Royal Society B: Biological Sciences 284, no. 1857 (2017): 20170525. http://dx.doi.org/10.1098/rspb.2017.0525.

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Early initiation of antiretroviral therapy (ART) reduces the risk of drug-sensitive HIV transmission but may increase the transmission of drug-resistant HIV. We used a mathematical model to estimate the long-term population-level benefits of ART and determine the scenarios under which earlier ART (treatment at 1 year post-infection, on average) could decrease simultaneously both total and drug-resistant HIV incidence (new infections). We constructed an infection-age-structured mathematical model that tracked the transmission rates over the course of infection and modelled the patients' life ex

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25

Feasey, Nicholas, Raheelah Ahmad, Elizabeth Ashley, et al. "Insights of SEDRIC, the Surveillance and Epidemiology of Drug-Resistant Infections Consortium." Wellcome Open Research 10 (January 13, 2025): 5. https://doi.org/10.12688/wellcomeopenres.23494.1.

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The increasing threat from infection with drug-resistant pathogens is among the most serious public health challenges of our time. Formed by Wellcome in 2018, the Surveillance and Epidemiology of Drug-Resistant Infections Consortium (SEDRIC) is an international think tank whose aim is to inform policy and change the way countries track, share, and analyse data relating to drug-resistant infections, by defining knowledge gaps and identifying barriers to the delivery of global surveillance. SEDRIC delivers its aims through discussions and analyses by world-leading scientists that result in recom

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26

Shankar, PRavi. "Book review: Tackling drug-resistant infections globally." Archives of Pharmacy Practice 7, no. 3 (2016): 110. http://dx.doi.org/10.4103/2045-080x.186181.

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27

MAHONEY, DIANA. "Drug-Resistant Bloodstream Infections Respond to Daptomycin." Family Practice News 35, no. 3 (2005): 31. http://dx.doi.org/10.1016/s0300-7073(05)71308-6.

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28

Jik Kwon, Young. "Polymeric transformer: Nanoantibiotics for drug-resistant infections." Research Outreach, no. 108 (July 10, 2019): 22–25. http://dx.doi.org/10.32907/ro-108-2225.

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29

Song, Jae-Hoon, and Doo Ryeon Chung. "Respiratory Infections Due to Drug-Resistant Bacteria." Infectious Disease Clinics of North America 24, no. 3 (2010): 639–53. http://dx.doi.org/10.1016/j.idc.2010.04.007.

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30

Grayson, L. "Management of drug-resistant gram-positive infections." International Journal of Infectious Diseases 73 (August 2018): 32. http://dx.doi.org/10.1016/j.ijid.2018.04.3496.

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31

Rupali, Priscilla. "PATIENT-CENTERED SURVEILLANCE OF DRUG-RESISTANT INFECTIONS." International Journal of Infectious Diseases 130 (May 2023): S43—S44. http://dx.doi.org/10.1016/j.ijid.2023.04.104.

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32

Begum, Wazeda, Md Saiful Kabir, Md Maruf Ur Rahman, and Md Mostafizur Rahman. "Drug resistant fungal infections An emerging threat." Journal of Dhaka National Medical College & Hospital 24, no. 1 (2018): 52–56. https://doi.org/10.3329/jdnmch.v24i1.80062.

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Drug resistance has become an important problem leading to significant negative social, psychological, and occupational health effects and quality of life. Clinical failure and relapses have been observed in patients treated with antifungal drugs. Now a days, Antifungal drug resistance is becoming an emerging threat in management of fungal infections especially in immunocompromised patients. Early recognition and treatment is essential to reduce morbidity and possibility of transmission. The increased use, inappropriate prescribing and over the counter sale of antifungal agents has also added

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33

Gondil, Vijay Singh. "Drug-Resistant Bacterial Infections and Alternative Therapies." Biomedicines 13, no. 2 (2025): 457. https://doi.org/10.3390/biomedicines13020457.

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The introduction of antibiotics in clinical use has revolutionized modern medicine practices and significantly contributed to the control of bacterial infections, which were the leading cause of morbidity and mortality throughout human history [...]

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34

Shelke, Rahul Rajendra, and Meera Chavan. "Screening plants for medicines against & species infections." Indian Journal of Microbiology Research 8, no. 2 (2021): 157–62. http://dx.doi.org/10.18231/j.ijmr.2021.032.

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species are multi drug resistant bacteria. These bacteria are resistant to number of antimicrobial agents. The research work was aimed at killing and inhibiting the growth of these multi drug resistant pathogens, by using phytochemicals. The phytochemicals are secondary metabolites produced by plants. According to WHO medicinal plants are best products for maintaining human health. Plants like (Behada)and (Chndan) found to be the most effective against all isolated multi drug resistant species and species. 20 pathogens were isolated on MacConkeys agar plate. Out of these isolates, all isolates

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35

Chadha, A., W. Jamal, and V. O. Rotimi. "Emergence of nosocomial-acquired extensively drug-resistant and pandrug-resistant Enterobacterales in a teaching hospital in Kuwait." African Journal of Clinical and Experimental Microbiology 23, no. 4 (2022): 426–36. http://dx.doi.org/10.4314/ajcem.v23i4.11.

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Background: The emergence and high ascendancy of infections caused by extensively-drug-resistant (XDR) and pandrug-resistant (PDR) Enterobacterales isolates is a serious clinical and public health challenge. Isolation of PDR Gram-negative bacteria (GNB) in clinical setting is very rare and rarer is the infection caused by XDR GNB. Apart from restricted therapeutic options, these infections are associated with increased mortality and morbidity. Urgent studies to re-evaluate existing therapeutic options and research into new antibiotic molecules are desperately needed. The objectives of this stu

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36

Zurawski, Ranae M. "Carbapenem-Resistant Enterobacteriaceae: Occult Threat in the Intensive Care Unit." Critical Care Nurse 34, no. 5 (2014): 44–51. http://dx.doi.org/10.4037/ccn2014602.

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Carbapenem-resistant Enterobacteriaceae are a group of virulent, drug-resistant gram-negative bacteria that are increasingly the cause of infection. Such infections are associated with a high morbidity and mortality and increased health care costs. Management of these infections requires recognition of patients at risk for multidrug-resistant microbial colonization and infections, identification of the causative organism, and rapid, appropriate treatment. Lack of awareness of proper isolation of patients harboring these organisms and delay in prescribing antibiotics such as tigecycline and pol

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37

Rafailidis, Petros, Periklis Panagopoulos, Christos Koutserimpas, and George Samonis. "Current Therapeutic Approaches for Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Infections." Antibiotics 13, no. 3 (2024): 261. http://dx.doi.org/10.3390/antibiotics13030261.

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The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A. baumannii infections on morbidity and mortality, as well on financial resources, remain dire. Furthermore, A. baumannii superinfections have also occurred during the COVID-19 pandemic. While prevention is important, the antibiotic armamentarium remains the most essential factor for the treatment of these infections. The main problem is the notorious resistance profile (in

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38

Proctor, Luke L., Whitney L. Ward, Conner S. Roggy, et al. "Potential Therapeutic Targets for Combination Antibody Therapy against Pseudomonas aeruginosa Infections." Antibiotics 10, no. 12 (2021): 1530. http://dx.doi.org/10.3390/antibiotics10121530.

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Despite advances in antimicrobial therapy and even the advent of some effective vaccines, Pseudomonas aeruginosa (P. aeruginosa) remains a significant cause of infectious disease, primarily due to antibiotic resistance. Although P. aeruginosa is commonly treatable with readily available therapeutics, these therapies are not always efficacious, particularly for certain classes of patients (e.g., cystic fibrosis (CF)) and for drug-resistant strains. Multi-drug resistant P. aeruginosa infections are listed on both the CDC’s and WHO’s list of serious worldwide threats. This increasing emergence of

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39

Siwakoti, Shraddha, Rinku Sah, Roshan Chhetri, and Basudha Khanal. "Bloodstream Infections in a Nepalese Tertiary Hospital-Aetiology, Drug Resistance and Clinical Outcome." Journal of Nepal Health Research Council 22, no. 03 (2024): 574–81. https://doi.org/10.33314/jnhrc.v22i03.5217.

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Background: Bloodstream infections (BSIs) are a leading cause of sepsis-related morbidity and mortality globally. We present the pathogenic agents of bloodstream infections, their antimicrobial susceptibilities, and associated outcomes, with a focus on drug-resistant cases.Methods: We included all adult patients admitted to B.P. Koirala Institute of Health Sciences with blood culture-positive sepsis from July 2019 to June 2020. Blood cultures and antimicrobial susceptibility tests followed standard methods. Demographic, clinical, and microbiological data, including clinical outcomes, were docu

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Kim, Tae Ho, Bui Thi Bich Hanh, Guehye Kim, et al. "Thiostrepton: A Novel Therapeutic Drug Candidate for Mycobacterium abscessus Infection." Molecules 24, no. 24 (2019): 4511. http://dx.doi.org/10.3390/molecules24244511.

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Mycobacterium abscessus is a rapid-growing, multidrug-resistant, non-tuberculous mycobacterial species responsible for a variety of human infections, such as cutaneous and pulmonary infections. M. abscessus infections are very difficult to eradicate due to the natural and acquired multidrug resistance profiles of M. abscessus. Thus, there is an urgent need for the development of effective drugs or regimens against M. abscessus infections. Here, we report the activity of a US Food and Drug Administration approved drug, thiostrepton, against M. abscessus. We found that thiostrepton significantly

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Fleming, Naomi. "AMR: effective infection prevention and control measures." Practice Nursing 30, no. 8 (2019): 390–95. http://dx.doi.org/10.12968/pnur.2019.30.8.390.

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Antimicrobial resistance is on the rise. As more infections are becoming resistant to antibiotic treatment, it would benefit practice nurses to be aware of the effective measures they can use to prevent the spread of infection, explains Naomi Fleming When micro-organisms are exposed to an antimicrobial, more susceptible organisms succumb, leaving behind those resistant to the antimicrobial. They can then pass on resistance to their offspring. The use and misuse of antimicrobials has increased the number and types of resistant organisms. As a result, standard treatments become ineffective and i

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42

Gottlieb, Ron D., Mahendra K. Shah, David C. Perlman, and Charles P. Kimmelman. "Community-Acquired Methicillin-Resistant Staphylococcus Aureus Infections in Otolaryngology." Otolaryngology–Head and Neck Surgery 107, no. 3 (1992): 434–37. http://dx.doi.org/10.1177/019459989210700316.

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Soon after the introduction of methicillin, strains of Staphylococcus aureus resistant to methicillin were reported. Methicillin-resistant Staphylococcus aureus (MRSA) has become a common hospital pathogen, often resistant to multiple antibiotics, while causing significant morbidity and mortality. Community-acquired MRSA infections have been infrequently documented. Most reports have been associated with intravenous drug abuse. This report reviews 15 patients with community-acquired MRSA infections of the head and neck. None admitted to intravenous drug use. Additionally, no patient was known

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43

Peloquin, Charles A. "Mycobacterial Infections." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 13, no. 6 (1993): 634–39. http://dx.doi.org/10.1002/j.1875-9114.1993.tb02771.x.

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Infection due to Mycobacterium tuberculosis continues to plague humanity. In the United States, conditions have taken a decided turn for the worse, with an increasing frequency of infection and the spread of multiple‐drug‐resistant strains. A number of strategies are available to improve the management of this epidemic. Mycobacterium avium is now recognized as a significant cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome. Therapy is limited due to relative drug resistance, drug intolerance, and drug malabsorption; however, potentially useful regimens ar

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44

Garcia Torres, Sara, Dirk Henrich, Rene D. Verboket, et al. "Bactericidal Effect of a Novel Phage Endolysin Targeting Multi-Drug-Resistant Acinetobacter baumannii." Antibiotics 14, no. 2 (2025): 162. https://doi.org/10.3390/antibiotics14020162.

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Background/Objectives: Infections with antibiotic-resistant Gram-negative pathogens represent a major global threat to public health. Acinetobacter baumannii is a highly important nosocomial pathogen causing severe and life-threatening infections, like pneumonia, wound infections, or sepsis. It is often resistant even against last-resort antibiotics, such as carbapenems, and can persist in healthcare settings. Artilysin®s are a novel class of endolysins targeted against multidrug-resistant bacteria. Methods: Antibacterial activity of Art-Top3 was determined by broth microdilution, in vitro ass

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45

Alvseike, O., T. Leegaard, P. Aavitsland, and J. Lassen. "Trend of multiple drug resistant Salmonella Typhimurium in Norway." Eurosurveillance 7, no. 1 (2002): 5–7. http://dx.doi.org/10.2807/esm.07.01.00352-en.

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This article reports the trend of multidrug resistant Salmonella Typhimurium isolated from humans in Norway from 1998 to 2000. Most of the incidents with multiple resistant S. Typhimurium infection contracted in Norway have been DT104. We should therefore expect an increase of both primary and secondary infections if strains such as phage type DT104 with R-type ACSSuT become endemic.

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Zhao, Yanling, Haotian Li, Shizhang Wei, Xuelin Zhou, and Xiaohe Xiao. "Antimicrobial Effects of Chemical Compounds Isolated from Traditional Chinese Herbal Medicine (TCHM) Against Drug-Resistant Bacteria: A Review Paper." Mini-Reviews in Medicinal Chemistry 19, no. 2 (2018): 125–37. http://dx.doi.org/10.2174/1389557518666181017143141.

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Infectious diseases caused by pathogenic bacteria seriously threaten human lives. Although antibiotic therapy is effective in the treatment of bacterial infections, the overuse of antibiotics has led to an increased risk of antibiotic resistance, putting forward urgent requirements for novel antibacterial drugs. Traditional Chinese herbal medicine (TCHM) and its constituents are considered to be potential sources of new antimicrobial agents. Currently, a series of chemical compounds purified from TCHM have been reported to fight against infections by drug-resistant bacteria. In this review, we

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Ramirez, Maria Soledad, Robert A. Bonomo, and Marcelo E. Tolmasky. "Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace." Biomolecules 10, no. 5 (2020): 720. http://dx.doi.org/10.3390/biom10050720.

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Acinetobacter baumannii is a common cause of serious nosocomial infections. Although community-acquired infections are observed, the vast majority occur in people with preexisting comorbidities. A. baumannii emerged as a problematic pathogen in the 1980s when an increase in virulence, difficulty in treatment due to drug resistance, and opportunities for infection turned it into one of the most important threats to human health. Some of the clinical manifestations of A. baumannii nosocomial infection are pneumonia; bloodstream infections; lower respiratory tract, urinary tract, and wound infect

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Echols, Roger, Mari Ariyasu, and Tsutae Den Nagata. "Pathogen-focused Clinical Development to Address Unmet Medical Need: Cefiderocol Targeting Carbapenem Resistance." Clinical Infectious Diseases 69, Supplement_7 (2019): S559—S564. http://dx.doi.org/10.1093/cid/ciz829.

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AbstractHistorically, the regulatory requirements of the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for developing new antibiotics have not addressed pathogen-focused indications for drug approval. The design of the necessary randomized controlled trials traditionally involves the enrollment of patients with site-specific infections caused by susceptible as well as resistant pathogens. Cefiderocol has undergone a streamlined clinical development program to address serious carbapenem-resistant infections. The regulatory approach, and the pivotal clinical trial

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Baliga, Shrikala, Prerna Khurana, Suchitra Shenoy, and Prasanna Mithra. "A RISING THREAT – RISK FACTORS AND OUTCOMES RELATED TO INFECTIONS WITH ACINETOBACTER SPECIES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 108. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.15364.

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ABSTRACTObjective: Acinetobacter species is an important cause of community as well as nosocomial infections with a high mortality rate. The study was doneto analyze the risk factors associated with Acinetobacter infections and their outcomes.Methods: The clinical details of 100 patients having infections with Acinetobacter species over a period of 1-year were analyzed for underlying riskfactors and outcomes. The antibiotic sensitivity results were interpreted according to the Clinical Laboratory Standards Institute guidelines.Results: Majority of the infections caused by the Acinetobacter spe

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Arias, Cesar A., and Barbara E. Murray. "Emergence and management of drug-resistant enterococcal infections." Expert Review of Anti-infective Therapy 6, no. 5 (2008): 637–55. http://dx.doi.org/10.1586/14787210.6.5.637.

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