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1

Heifets, Leonid B. "Drug Susceptibility Testing." Clinics in Laboratory Medicine 16, no. 3 (1996): 641–56. http://dx.doi.org/10.1016/s0272-2712(18)30259-2.

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2

Warnock, David W., and Elizabeth M. Johnson. "Antifungal drug susceptibility testing." Current Opinion in Infectious Diseases 10, no. 6 (1997): 444–48. http://dx.doi.org/10.1097/00001432-199712000-00006.

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3

Van Cutsem, J., H. Kurata, H. Matsuoka, et al. "Antifungal drug susceptibility testing." Medical Mycology 32, s1 (1994): 267–76. http://dx.doi.org/10.1080/02681219480000891.

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4

Genetu Bayih, Abebe, Anjan Debnath, Edward Mitre, et al. "Susceptibility Testing of Medically Important Parasites." Clinical Microbiology Reviews 30, no. 3 (2017): 647–69. http://dx.doi.org/10.1128/cmr.00111-16.

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SUMMARY In the last 2 decades, renewed attention to neglected tropical diseases (NTDs) has spurred the development of antiparasitic agents, especially in light of emerging drug resistance. The need for new drugs has required in vitro screening methods using parasite culture. Furthermore, clinical laboratories sought to correlate in vitro susceptibility methods with treatment outcomes, most notably with malaria. Parasites with their various life cycles present greater complexity than bacteria, for which standardized susceptibility methods exist. This review catalogs the state-of-the-art methodo
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5

Prasad, Dr Rajendra. "MOLECULAR DRUG SUSCEPTIBILITY TEST FOR EARLY DIAGNOSIS FOR DRUG RESISTANT TUBERCULOSIS." Era's Journal of Medical Research 10, no. 2 (2023): 47–50. http://dx.doi.org/10.24041/ejmr2023.35.

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The rise of drug-resistant tuberculosis poses a severe danger to the global effort to eradicate tuberculosis (DR-TB). Delays in the application of drug susceptibility testing (DST) based on culture led to extended durations of treatment failure and persistent tuberculosis transmission. This article's objective is to give a summary of the several rapid molecular drug susceptibility tests that have proven helpful in promptly identifying DR-TB cases, enabling prompt and efficient treatment of those individuals.
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6

Warnock, David W., Beth A. Arthington-Skaggs, and Ren-Kai Li. "Antifungal drug susceptibility testing and resistance in Aspergillus." Drug Resistance Updates 2, no. 5 (1999): 326–34. http://dx.doi.org/10.1054/drup.1999.0092.

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7

Upcroft, Jacqueline A., and Peter Upcroft. "Drug Susceptibility Testing of Anaerobic Protozoa." Antimicrobial Agents and Chemotherapy 45, no. 6 (2001): 1810–14. http://dx.doi.org/10.1128/aac.45.6.1810-1814.2001.

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ABSTRACT A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoaTrichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. The technique employs a commercially available sachet and bag system to generate a low-oxygen environment and log2 drug dilutions in microtiter plates, which can be monitored without aerobic exposure, to assay drug-resistant laboratory lines and clinically resistant isolates. MICs (after 2 da
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8

Leslie, David E. "Mycobacterium drug susceptibility testing – an update." Pathology 42 (2010): S51—S52. http://dx.doi.org/10.1097/01268031-201042001-00100.

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9

Ingen, Jakko van, and Ed J. Kuijper. "Drug susceptibility testing of nontuberculous mycobacteria." Future Microbiology 9, no. 9 (2014): 1095–110. http://dx.doi.org/10.2217/fmb.14.60.

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10

Rousseau, Paul, and Martine Dupuis. "Antituberculous drug susceptibility testing of Mycobacterium bovis BCG strain Montréal." Canadian Journal of Microbiology 36, no. 10 (1990): 735–37. http://dx.doi.org/10.1139/m90-125.

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Testing of Mycobacterium bovis BCG strain Montréal for susceptibility to four primary antituberculous drugs (isoniazid, ethambutol, streptomycin, and rifampin) and to one secondary drug (p-aminosalicylic acid) showed the strain to be susceptible to all five substances. Mycobacterium bovis strains ATCC 35735, which is isoniazid sensitive, and ATCC 35747, which is isoniazid resistant, were included in the test; with the exception of their respective susceptibility to isoniazid, both were inhibited by the other four drugs. Key words: BCG Montréal, drug susceptibility, cancer.
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11

Miotto, Paolo, Ying Zhang, Daniela Maria Cirillo, and Wing Cheong Yam. "Drug resistance mechanisms and drug susceptibility testing for tuberculosis." Respirology 23, no. 12 (2018): 1098–113. http://dx.doi.org/10.1111/resp.13393.

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12

Rabab, Batool, Imran Muhammad, Hafeez Kandhro Abdul, Salahuddin Naseem, and K. H. Uddin Muhammad. "Resistance Patterns among Multidrug-Resistant Tuberculosis Patients: A Multi-Center Study from Pakistan." International Journal of Endorsing Health Science Research 5, no. 4 (2017): 07–11. https://doi.org/10.29052/IJEHSR.v5.i4.2017.07-11.

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Abstract <strong>Background:</strong>&nbsp;The high burden of multi-drug resistance tuberculosis (MDR TB) is a matter of great concern.&nbsp; The increasing resistance to anti tuberculosis drugs has been the area of growing concern and are posing threats to TB control. The aim of this study was to evaluate the drug resistance patterns for the first line and second line anti-Tuberculosis drugs in multiple drug resistant tuberculosis (MDR-TB) patients. <strong>Method:</strong>&nbsp;The study was retrospective, observational, employing purposive, non-random sampling technique for data collection
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13

Maji, ArdhenduK. "Drug susceptibility testing methods of antimalarial agents." Tropical Parasitology 8, no. 2 (2018): 70. http://dx.doi.org/10.4103/2229-5070.248695.

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14

Aksamit, Timothy R., and Theodore K. Marras. "Clofazimine Drug Susceptibility Testing for Nontuberculous Mycobacteria." Chest 160, no. 1 (2021): e90. http://dx.doi.org/10.1016/j.chest.2021.02.059.

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15

Baldanti, Fausto, Karen K. Biron, and Giuseppe Gerna. "Interpreting Human Cytomegalovirus Antiviral Drug Susceptibility Testing." Journal of Infectious Diseases 177, no. 3 (1998): 823. http://dx.doi.org/10.1086/514224.

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16

Prescott, J. F., and J. D. Baggot. "Antimicrobial susceptibility testing and antimicrobial drug dosage." Journal of the American Veterinary Medical Association 187, no. 4 (1985): 363–68. https://doi.org/10.2460/javma.1985.187.04.363.

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17

O. Simons, Sami, and Dick van Soolingen. "Drug Susceptibility Testing for Optimizing Tuberculosis Treatment." Current Pharmaceutical Design 17, no. 27 (2011): 2863–74. http://dx.doi.org/10.2174/138161211797470255.

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18

Wiederhold, Nathan P. "Antifungal susceptibility testing, pharmacokinetics and pharmacodynamics, and therapeutic drug monitoring: putting it together." One Health Mycology 2, no. 1 (2023): 42–52. https://doi.org/10.63049/ohm.25.21.3.

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Laboratory tests are often used by clinicians to help in the management of patients with invasive fungal infections. Two types of tests that are commonly used include in vitro susceptibility testing and therapeutic drug monitoring. Antifungal susceptibility testing is a phenotypic means used to determine if an organism cultured from a patient with an infection may be susceptible or resistant to a particular drug or group of drugs. The results of susceptibility testing are most useful when interpretive breakpoints are available. Therapeutic drug monitoring is used to measure concentrations of a
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19

Saluzzo, F., F. Masood, V. Batignani, et al. "TB drug susceptibility testing in high fluoroquinolone resistance settings." IJTLD OPEN 1, no. 5 (2024): 230–35. http://dx.doi.org/10.5588/ijtldopen.24.0006.

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&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;/title&gt;The insurgence of resistance to key drugs of the BPaLM (bedaquiline + pretomanid + moxifloxacin) regimen is a major concern. In settings with widespread resistance to fluoroquinolones (FQs), like Pakistan, new technologies, such as Xpert® MTB/XDR, may ensure drug resistance upfront screening. This study aims to assess MTB/XDR's performance in detecting FQs and isoniazid resistance, proposing a renewed diagnostic algorithm for drug-resistant TB (DR-TB).&lt;/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;/title&gt;This cross-sectional prospective study,
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20

Shafer, Robert W. "Genotypic Testing for Human Immunodeficiency Virus Type 1 Drug Resistance." Clinical Microbiology Reviews 15, no. 2 (2002): 247–77. http://dx.doi.org/10.1128/cmr.15.2.247-277.2002.

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SUMMARY There are 16 approved human immunodeficiency virus type 1 (HIV-1) drugs belonging to three mechanistic classes: protease inhibitors, nucleoside and nucleotide reverse transcriptase (RT) inhibitors, and nonnucleoside RT inhibitors. HIV-1 resistance to these drugs is caused by mutations in the protease and RT enzymes, the molecular targets of these drugs. Drug resistance mutations arise most often in treated individuals, resulting from selective drug pressure in the presence of incompletely suppressed virus replication. HIV-1 isolates with drug resistance mutations, however, may also be
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21

Park, W. G., W. R. Bishai, R. E. Chaisson, and S. E. Dorman. "Performance of the Microscopic Observation Drug Susceptibility Assay in Drug Susceptibility Testing for Mycobacterium tuberculosis." Journal of Clinical Microbiology 40, no. 12 (2002): 4750–52. http://dx.doi.org/10.1128/jcm.40.12.4750-4752.2002.

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22

Van den Bossche, A., R. Bhattacharyya, J. Y. Coppee, et al. "RNA-BASED DRUG SUSCEPTIBILITY TESTING OF MYCOBACTERIUM TUBERCULOSIS." Russian Journal of Infection and Immunity 8, no. 4 (2019): 584–85. http://dx.doi.org/10.15789/2220-7619-2018-4-6.58.

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23

Tobin, Nicole H., and Lisa M. Frenkel. "Human immunodeficiency virus drug susceptibility and resistance testing." Pediatric Infectious Disease Journal 21, no. 7 (2002): 681–83. http://dx.doi.org/10.1097/00006454-200207000-00015.

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24

Huang, Wei-Chang, Ming-Chih Yu, and Yi-Wen Huang. "Identification and drug susceptibility testing for nontuberculous mycobacteria." Journal of the Formosan Medical Association 119 (June 2020): S32—S41. http://dx.doi.org/10.1016/j.jfma.2020.05.002.

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25

Zhang, Z. T., D. B. Wang, C. Y. Li, et al. "Microbial sensor for drug susceptibility testing ofMycobacterium tuberculosis." Journal of Applied Microbiology 124, no. 1 (2017): 286–93. http://dx.doi.org/10.1111/jam.13617.

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26

Hoel, TERJE, and JAN Eng. "Radiometric and conventional drug susceptibility testing ofMycobacterium tuberculosis." APMIS 99, no. 7-12 (1991): 977–80. http://dx.doi.org/10.1111/j.1699-0463.1991.tb01287.x.

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27

Grushnikov, Andrey, Kazuma Kikuchi, Yoshimi Matsumoto, Takeo Kanade, and Yasushi Yagi. "Automatic Image Analysis for Rapid Drug Susceptibility Testing." Advanced Biomedical Engineering 6 (2017): 76–82. http://dx.doi.org/10.14326/abe.6.76.

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28

Pfaller, M. "Antifungal Susceptibility Testing Methods." Current Drug Targets 6, no. 8 (2005): 929–43. http://dx.doi.org/10.2174/138945005774912708.

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29

Laszlo, Adalbert, Dorothy M. Helbecque, and Walter Tostowaryk. "Proficiency testing of conventional drug susceptibility tests of Mycobacterium tuberculosis." Canadian Journal of Microbiology 33, no. 12 (1987): 1064–68. http://dx.doi.org/10.1139/m87-186.

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Proficiency testing of indirect drug susceptibility tests of Mycobacterium tuberculosis was begun in 1985 by the Laboratory Centre for Disease Control (LCDC) with the participation of Provincial Public Health Laboratories in Canada. Comparable sets of 60 cultures of Mycobacterium tuberculosis representing 30 strains were distributed by LCDC to the participating laboratories to be tested for drug susceptibility against isoniazid, streptomycin, rifampin, and ethambutol using conventional methodologies. Intralaboratory agreement values determined by comparing results obtained on sets of duplicate
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30

Coronel, J., M. H. Roper, C. Herrera, et al. "Validation of microscopic observation drug susceptibility testing for rapid, direct rifampicin and isoniazid drug susceptibility testing in patients receiving tuberculosis treatment." Clinical Microbiology and Infection 20, no. 6 (2014): 536–41. http://dx.doi.org/10.1111/1469-0691.12401.

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31

Chevillotte, Meike, Ina Ersing, Thomas Mertens, and Jens von Einem. "Differentiation between Polymorphisms and Resistance-Associated Mutations in Human Cytomegalovirus DNA Polymerase." Antimicrobial Agents and Chemotherapy 54, no. 12 (2010): 5004–11. http://dx.doi.org/10.1128/aac.00259-10.

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ABSTRACT Specific mutations in the human cytomegalovirus (HCMV) DNA polymerase (pUL54) are known to confer resistance against all currently licensed drugs for treatment of HCMV infection and disease. Following the widespread use of antivirals, the occurrence of HCMV drug resistance is constantly increasing. Recently, diagnostic laboratories have started to replace phenotypic drug resistance testing with genotypic resistance testing. However, the reliability and success of genotypic testing highly depend on the availability of high-quality phenotypic resistance data for each individual mutation
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32

Caviedes, Luz, Tien-Shun Lee, Robert H. Gilman, et al. "Rapid, Efficient Detection and Drug Susceptibility Testing of Mycobacterium tuberculosis in Sputum by Microscopic Observation of Broth Cultures." Journal of Clinical Microbiology 38, no. 3 (2000): 1203–8. http://dx.doi.org/10.1128/jcm.38.3.1203-1208.2000.

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Inexpensive, rapid, and reliable methods of detecting infection by and drug susceptibility of Mycobacterium tuberculosis (MTB) are crucial to the control of tuberculosis. The novel microscopic observation broth-drug susceptibility assay (MODS) detects early growth of MTB in liquid medium, allowing more timely diagnosis and drug susceptibility testing. Sputum samples from hospitalized patients in Peru were analyzed by using stains, culture, and PCR. Sensitivity of MODS (92%) compared favorably with the most sensitive of the other culture methods (93%). Sputum samples positive for tuberculosis w
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33

Merid, Yared, Elena Hailu, Getnet Habtamu, et al. "Molecular Epidemiology of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in south Ethiopia." Journal of Infection in Developing Countries 15, no. 09 (2021): 1299–307. http://dx.doi.org/10.3855/jidc.14742.

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Introduction: Understanding the epidemiology of tuberculosis is limited by lack of genotyping data. We sought to characterize the drug susceptibility testing patterns and genetic diversity of M. tuberculosis isolates in southern Ethiopia.&#x0D; Methodology: A cross-sectional study was conducted among newly diagnosed sputum smear positive patients with tuberculosis visiting nine health facilities in southern Ethiopia from June 2015 to May 2016. Three consecutive sputum samples (spot-morning-spot) per patient were examined using acid-fast bacilli smear microscopy with all smear positive specimen
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34

Schoutrop, Esther L. M., Michelle A. E. Brouwer, Josien C. A. Jenniskens, et al. "The stability of antimycobacterial drugs in media used for drug susceptibility testing." Diagnostic Microbiology and Infectious Disease 92, no. 4 (2018): 305–8. http://dx.doi.org/10.1016/j.diagmicrobio.2018.06.015.

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35

Maves, Ryan C., Rosa Castillo, Alfredo Guillen, et al. "Antimicrobial Susceptibility ofBrucella melitensisIsolates in Peru." Antimicrobial Agents and Chemotherapy 55, no. 3 (2011): 1279–81. http://dx.doi.org/10.1128/aac.00979-10.

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ABSTRACTBrucellosis is an important public health problem in Peru. We evaluated 48 humanBrucella melitensisbiotype 1 strains from Peru between 2000 and 2006. MICs of isolates to doxycycline, azithromycin, gentamicin, rifampin, ciprofloxacin, and trimethoprim-sulfamethoxazole were determined by the Etest method. All isolates were sensitive to tested drugs during the periods of testing. Relapses did not appear to be related to drug resistance.
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36

Jha1, Vikas, BS Ajit Kumar, Sampurna Panigrahi, Gayatri Nair, and Nikitha Bangera. "An Overview of the Drug Susceptibility Testing for Tuberculosis." Acta Scientific Microbiology 3, no. 8 (2020): 47–56. http://dx.doi.org/10.31080/asmi.2020.03.0653.

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37

Kim, Sang Jae, Gill Han Bai, and Sung Chan Yang. "Drug Susceptibility Testing for Mycobacterium tuberculosis Using Microtiter Plate." Tuberculosis and Respiratory Diseases 37, no. 3 (1990): 278–87. http://dx.doi.org/10.4046/trd.1990.37.3.278.

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38

Wang, Ruibai, Xiuqin Zhao, and Kanglin Wan. "Deterioration of Cycloserine in Drug Susceptibility Testing of Mycobacterium." Infection and Drug Resistance Volume 15 (January 2022): 135–40. http://dx.doi.org/10.2147/idr.s348428.

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39

Vanithadevi, E. "Technological Advances in Drug Susceptibility Testing-Diagnosis of Tuberculosis." International Journal of Current Microbiology and Applied Sciences 7, no. 06 (2018): 3127–35. http://dx.doi.org/10.20546/ijcmas.2018.706.367.

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40

Shaik Mujafar, Boddu Ganesh, Kesani Meghana, Nuthalapati Amani, and Shaik Faizan Ali. "A study on fungal speciation and drug susceptibility testing." International Journal of Novel Trends in Pharmaceutical Sciences 10, no. 2 (2020): 57–62. http://dx.doi.org/10.26452/ijntps.v10i2.1270.

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Fungal infections affect many people but most of these do not come to light as they are mild in clinical presentation. Candidiasis is the frequent fungal infection involving mucosa, skin, nails and internal organs caused by different species of Candida and Candida albicans being the prototype. The clinical manifestations vary with duration and severity. It occurs mostly as a comorbid disease with a primary disease or disorder. Candida comes under the phylum Fungi Imperfecti, order Moniliales and family Cryptococcaceae. Genus Candida comprises of 20 important species recognised as pathogenic in
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41

&NA;. "New Approaches to Rapid Drug Susceptibility Testing of TB." Clinical Pulmonary Medicine 1, no. 1 (1994): 65. http://dx.doi.org/10.1097/00045413-199401000-00009.

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42

Khurana, Ananta, Kabir Sardana, Anuradha Chowdhary, and Khushboo Sethia. "Clinical implications of antifungal drug susceptibility testing of dermatophytes." Indian Dermatology Online Journal 10, no. 6 (2019): 737. http://dx.doi.org/10.4103/idoj.idoj_253_19.

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43

Kalokhe, Ameeta S., James C. Lee, Susan M. Ray, et al. "Multidrug-Resistant Tuberculosis Drug Susceptibility and Molecular Diagnostic Testing." American Journal of the Medical Sciences 345, no. 2 (2013): 143–48. http://dx.doi.org/10.1097/maj.0b013e31825d32c6.

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44

Reena, K., and V. Shanthi. "Evolution of In vitro Drug Susceptibility Testing of Pyrazinamide." Biosciences Biotechnology Research Asia 10, no. 2 (2013): 803–9. http://dx.doi.org/10.13005/bbra/1199.

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45

van Ingen, Jakko, Martin J. Boeree, Dick van Soolingen, and Johan W. Mouton. "Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria." Drug Resistance Updates 15, no. 3 (2012): 149–61. http://dx.doi.org/10.1016/j.drup.2012.04.001.

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46

Hewlett, D. "Drug-resistant tuberculosis: inconsistent results of pyrazinamide susceptibility testing." JAMA: The Journal of the American Medical Association 273, no. 12 (1995): 916–17. http://dx.doi.org/10.1001/jama.273.12.916.

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47

Hewlett, Dial. "Drug-Resistant Tuberculosis: Inconsistent Results of Pyrazinamide Susceptibility Testing." JAMA: The Journal of the American Medical Association 273, no. 12 (1995): 916. http://dx.doi.org/10.1001/jama.1995.03520360030022.

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48

Reinders, Paul P., Philip H. van Vianen, Maarten van der Keur, Anneloes van Engen, Chris J. Janse, and Hans J. Tanke. "Computer software for testing drug susceptibility of malaria parasites." Cytometry 19, no. 3 (1995): 273–81. http://dx.doi.org/10.1002/cyto.990190312.

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49

Tolchkov, V., Y. Hodzhev, B. Tsafarova, et al. "Drug susceptibility testing of Mycobacterium tuberculosis using next generation sequencing and Mykrobe software." Journal of microbiology, epidemiology and immunobiology 98, no. 6 (2022): 697–705. http://dx.doi.org/10.36233/0372-9311-191.

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Introduction. Mycobacterium tuberculosis is the causative agent of tuberculosis. Drug susceptibility testing is performed by phenotypic and molecular tests. Commonly used for phenotypic drug susceptibility testing is the automated BACTEC system in a liquid culture medium. Drug susceptibility by line probe molecular tests was introduced almost 15 years ago. Recently whole genome sequencing (WGS) analysis of M. tuberculosis strains demonstrated that genotyping of drug-resistance could be accurately performed. Several software tools were developed.Our study aimed to perform whole-genome sequencin
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50

MOHD, JASEEM Khan. "INCONGRUENT RESISTANCE TO AMINOGLYCOSIDES IN MULTIDRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS." INTERNATIONAL JOURNAL OF SCIENCES AND APPLIED RESEARCH 12, no. 2 (2025): 01–06. https://doi.org/10.5281/zenodo.14868929.

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Since the discovery of the bactericidal activity of aminoglycosides, streptomycin, kanamycin, amikacin, and capreomycin (a macrocyclic peptide) have been widely used to treat tuberculosis and multidrug-resistant (MDR) tuberculosis. In general practice, resistance to kanamycin is often used as the sole criterion for defining extensively drug-resistant tuberculosis, assuming that all other drugs in this group or related drugs are resistant to certain strains. However, the assumption of cross-resistance between drugs in the same group is not always true for Mycobacterium tuberculosis. This prompt
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