Journal articles: 'Drug therapy problems'

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McDonough, Randy P. "Finding Drug Therapy Problems." Journal of the American Pharmaceutical Association (1996) 39, no. 4 (April 1999): 568–70. http://dx.doi.org/10.1016/s1086-5802(16)30479-x.

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&NA;. "Problems in Pediatric Drug Therapy." American Journal of Nursing 96, no. 3 (March 1996): 56. http://dx.doi.org/10.1097/00000446-199603000-00034.

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Pagliaro, Louis A., Ann M. Pagliaro, and Jo Ann Jackson. "Problems in Pediatric Drug Therapy." Therapeutic Drug Monitoring 11, no. 1 (January 1989): 118. http://dx.doi.org/10.1097/00007691-198901000-00030.

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Mulligan-Smith, Deborah. "Problems in Pediatric Drug Therapy." Pediatric Emergency Care 12, no. 5 (October 1996): 387. http://dx.doi.org/10.1097/00006565-199610000-00017.

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Chaves-Carballo, Enrique. "Problems in pediatric drug therapy." Pediatric Neurology 13, no. 2 (September 1995): 181. http://dx.doi.org/10.1016/0887-8994(95)90028-4.

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Patil, Shraddha B., Bhavana U. Jain, and Manish Kondawar. "A Review on Drug Therapy Problems." Asian Journal of Research in Pharmaceutical Science 9, no. 2 (2019): 137. http://dx.doi.org/10.5958/2231-5659.2019.00020.1.

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Leff, Richard D., and Robert J. Roberts. "Problems in drug therapy for pediatric patients." American Journal of Health-System Pharmacy 44, no. 4 (April 1, 1987): 865–78. http://dx.doi.org/10.1093/ajhp/44.4.865.

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Reed, Michael D. "Book Review: Problems in Pediatric Drug Therapy." Drug Intelligence & Clinical Pharmacy 22, no. 6 (June 1988): 508. http://dx.doi.org/10.1177/106002808802200620.

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Prosser, Sue, and Jo Daly. "Problems in Pediatric Drug Therapy, 4th edition." Journal of Advanced Nursing 47, no. 5 (September 2004): 576. http://dx.doi.org/10.1111/j.1365-2648.2004.03146_1.x.

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Bourgeois, B. F. D. "Problems of Combination Drug Therapy in Children." Epilepsia 29, s3 (December 1988): S20—S24. http://dx.doi.org/10.1111/j.1528-1157.1988.tb05806.x.

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Kefale, Belayneh, Gobezie T. Tegegne, Yitayih Kefale, Mulugeta Molla, Amien Ewunetei, and Amsalu Degu. "Magnitude and determinants of drug therapy problems among type 2 diabetes mellitus patients with hypertension in Ethiopia." SAGE Open Medicine 8 (January 2020): 205031212095469. http://dx.doi.org/10.1177/2050312120954695.

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Introduction: Type 2 diabetes mellitus patients with hypertension are at high risk of drug therapy problems since they are subject to receive multiple drug therapies due to comorbidities. Objectives: To determine the magnitude of drug therapy problems and its determinants among Type 2 diabetes mellitus patients with hypertension. Methods: A cross-sectional study was employed among 423 randomly selected participants based on the inclusion criteria. A structured questionnaire and review of patients’ medical record were employed in the data collection. The classification system used by Cipolle was used to classify and evaluate drug therapy problems. Data were analyzed using Statistical Package for the social sciences version 25.0 software. Multivariate logistic regression analysis was used to identify determinants of drug therapy problems with a statistical significance of p ⩽ 0.05. Results: A total of 491 drug therapy problems with a mean of 1.86 ± 0.53 drug therapy problems per patient were identified, and 62.4% (264) of them experienced at least one drug therapy problem. Non-compliance (197, 40.1%), needs of additional drug therapy (119, 24.2%), and dosage too low (91, 18.5%) were the most frequently observed drug therapy problems in the study setting. Anti-diabetic medications (88.4%), statins (44.5%), and aspirin (33.5%) were the most commonly involved drugs in drug therapy problems. The determinants of drug therapy problems were very low family income (adjusted odds ratio = 4.64, p = 0.010), age (45–65 years old) (adjusted odds ratio = 2.55, p = 0.008), presence of comorbidity (adjusted odds ratio = 9.19, p < 0.001), and taking ⩾5 medications (adjusted odds ratio = 2.84, p = 0.001). Conclusion: Approximately three out of five patients had one or more drug therapy problems encountered. In this study, the most common types of drug therapy problems were non-compliance, needs additional drug therapy, and dosage too low. Family monthly income, age, comorbidities, and number of medications were the significant determinants of drug therapy problems. Therefore, patient education regarding medication adherence, routine medication review, and strengthening clinical pharmacy services should be promoted.

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Lumbantobing, Romauli, Rani Sauriasari, and Retnosari Andrajati. "ROLE OF PHARMACISTS IN REDUCING DRUG-RELATED PROBLEMS IN HEMODIALYSIS OUTPATIENTS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 17 (October 1, 2017): 108. http://dx.doi.org/10.22159/ajpcr.2017.v10s5.23110.

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Objectives: Hemodialysis outpatients have a higher risk of developing drug-related problems. Pharmacists play a key role in identifying and preventing these drug-related problems. This study aimed to assess the effect of pharmacist intervention on the number and types of drug-related problems in outpatients undergoing hemodialysis at Indonesia Christian University Hospital.Methods: This pre- and post-prospective study was conducted from January 2013 to June 2013. We evaluated 86 patients who were prescribed 804 drugs.Results: A total of 337 drug-related problems were identified (41.86% of the total drugs prescribed). The types of drug-related problems identified were as follows: Failed therapy (18.69%); sub-optimal therapy (52.23%); indication of non-administration of therapy (2.37%); and non-allergic adverse drug effects (26.71%). The physicians received 59 recommendations, and the patients received 278 recommendations. These recommendations resulted in a decrease in ineffective drug therapy or therapeutic failure (18.69-0%), sub-optimal therapy (52.23-21.36%), indications of non-administration of drug (2.37-2.08%), and non-allergic adverse drug effects (26.71-9.20%). The factors that significantly affected the occurrence of drug-related problems were hemodialysis frequency, number of comorbidities, and number of drugs prescribed. Patients undergoing hemodialysis 3 times a week were more likely to experience a decrease in drug-related problems than those undergoing hemodialysis twice a week (odds ratio 26.33, 95% confidence interval 2.710-255.884).Conclusions: Pharmacist intervention could decrease drug-related problems in hemodialysis patients.

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Nouri, Toni. "Drug-resistant propionibacteria cause problems in acne therapy." Inpharma Weekly &NA;, no. 1031 (April 1996): 3–4. http://dx.doi.org/10.2165/00128413-199610310-00004.

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Ebihara, A., Akira Seki, C. Ogura, Tamotsu Matsuda, Iwao Kuwajima, Toshiyuki Yamamoto, and Y. Mizushima. "Problems of the Drug Therapy in the Elderly." Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 26, no. 2 (1989): 111–45. http://dx.doi.org/10.3143/geriatrics.26.111.

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Wilson, C. L., A. Bradlow, and F. Wojnarowska. "Cutaneous Problems with Drug Therapy in Rheumatoid Arthritis." International Journal of Dermatology 30, no. 2 (February 1991): 148–49. http://dx.doi.org/10.1111/j.1365-4362.1991.tb04231.x.

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Shimp, Leslie A., Frank J. Ascione, Howard M. Glazer, and Beverly F. Atwood. "Potential Medication-Related Problems in Noninstitutionalized Elderly." Drug Intelligence & Clinical Pharmacy 19, no. 10 (October 1985): 766–72. http://dx.doi.org/10.1177/106002808501901024.

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The extent of potential medication-related problems was examined using a thorough review of drug therapy for 53 elderly patients who averaged five chronic illnesses and who used a mean of 11 drugs. An average of 11 specific potential medication-related problems was identified for each patient. These problems fell into three broad categories: Drug toxicity, physician prescribing, and patient medication behaviors. The strongest predictor of the total number of potential problems was the number of prescription medications. The type of drug therapy review used in this study can help health professionals identify and prevent the types of medication-related problems occurring in multiple medication users.

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Bizuneh, Gizachew Kassahun, Betelhem Anteneh Adamu, Getenet Tadege Bizuayehu, and Solomon Debebe Adane. "A Prospective Observational Study of Drug Therapy Problems in Pediatric Ward of a Referral Hospital, Northeastern Ethiopia." International Journal of Pediatrics 2020 (March 21, 2020): 1–6. http://dx.doi.org/10.1155/2020/4323189.

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Background. A drug therapy problem is any undesirable event experienced by a patient during drug therapy that interferes with achieving the desired goals of therapy. It has been pointed out that hospitalized pediatric patients are particularly prone to drug-related problems. Identifying drug therapy problems enables risk quantification and determination of the potential impact of prevention strategies. The purpose of this study was to assess the drug therapy problems in a pediatric ward of Dessie Referral Hospital, northeast of Ethiopia, and to identify associated factors for drug therapy problems. Methods. A prospective observational study design was carried out to assess drug therapy problems in a pediatric ward of Dessie Referral Hospital from February 1, 2018, to May 30, 2018. Ethical approval was obtained, and informed consent was signed by each study participant’s parent before the commencement of the study. All patients admitted to the ward during the study period were included in the study. Data was collected by trained pharmacy staffs through medical record reviews of patients using a prepared standard checklist and semistructured questionnaire. The collected data were cleared and checked every day for completeness and consistency before processing. Data were entered, and descriptive statistical analysis was done using SPSS Version 20 Software. A P value of less than 0.05 was considered significant. Results. The participants’ mean age was 2.32 years with the standard deviation (SD) of 0.76 years. Among 81 patients, 71 (87.7%) of them had at least one drug therapy problem per patient which indicates that the prevalence of the drug therapy problem was substantially high. Needs additional drug was the most predominantly encountered drug therapy problem accounted (30 (25.2%)). On the other hand, ineffective drug was the least (3 (2.5%)) drug therapy problem. Antibiotics (47 (39.5%)) followed by fluid and electrolyte (25 (21%)) were classes of drugs mostly involved in the drug therapy problem. The main risk factors reported to the occurrence of the drug therapy problems were prescribing and dose calculation errors. Conclusion. The present study revealed that majority of the patients had at least one DTP per patient; this indicates that prevalence of DTP was very high in the study area. Needs additional drug therapy followed by noncompliance was the major cause of the occurrence of DTP. Antibiotics were the main class of drugs involved in the drug therapy problem, and among the risk factors assessed, prescribing and dose calculation errors showed statistical significance.

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Craves, Kimberly. "Developmental Problems of Drug-Exposed Infants." Pediatric Physical Therapy 8, no. 1 (1996): 46. http://dx.doi.org/10.1097/00001577-199600810-00019.

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Michels, Karin B. "Problems Assessing Nonserious Adverse Drug Reactions: Antidepressant Drug Therapy and Sexual Dysfunction." Pharmacotherapy 19, no. 4 (April 1999): 424–29. http://dx.doi.org/10.1592/phco.19.6.424.31048.

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Chen, Dazhong, Fangyuan Xie, Duxin Sun, Chuan Yin, Jie Gao, and Yanqiang Zhong. "Nanomedicine-Mediated Combination Drug Therapy in Tumor." Open Pharmaceutical Sciences Journal 4, no. 1 (January 19, 2017): 1–10. http://dx.doi.org/10.2174/1874844901704010001.

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Background:Combined chemotherapy has gradually become one of the conventional methods of cancer treatment due to the limitation of monotherapy. However, combined chemotherapy has several drawbacks that may lead to treatment failure because drug synergy cannot be guaranteed, achievement of the optimal synergistic drug ratio is difficult, and drug uptake into the tumor is inconsistent. Nanomedicine can be a safe and effective form of drug delivery, which may address the problems associated with combination chemotherapy.Objective:This review summarizes the recent research in this area, including the use of nanoparticles, liposomes, lipid-polymer hybrid nanoparticles, and polymeric micelles, and provides new approach for combined chemotherapy.Methods:By collecting and referring to the related literature in recent years.Results:Compared with conventional drugs, nanomedicine has the following advantages: it increases bioavailability of poorly soluble drugs, prolongs drug circulation timein vivo, and permits multiple drug loading, all of which could improve drug efficacy and reduce toxicity. Furthermore, nanomedicine can maintain the synergistic ratio of the drugs; deliver the drugs to the tumor at the same time, such that two or more drugs of tumor treatment achieve synchronization in time and space; and alter the pharmacokinetics and distribution profilein vivosuch that these are dependent on nanocarrier properties (rather than being dependent on the drugs themselves).Conclusion:Therefore, nanomedicine-mediated combination drug therapy is promising in the treatment of tumors.

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Massoud, Neil. "New Publication: Problems in Pediatric Drug Therapy, 2nd Ed." Journal of Pharmacy Technology 4, no. 3 (May 1988): 92. http://dx.doi.org/10.1177/875512258800400302.

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Udezi, WA, CO Usifoh, and KC Amibor. "PHP59 DRUG THERAPY PROBLEMS: DOES PHARMACIST'S INTERVENTION SAVE COST?" Value in Health 11, no. 3 (May 2008): A46—A47. http://dx.doi.org/10.1016/s1098-3015(10)70157-1.

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Lindsay, Christine A. "Book Review: Problems in Pediatric Drug Therapy. 3rd Edition." Annals of Pharmacotherapy 30, no. 2 (February 1996): 197. http://dx.doi.org/10.1177/106002809603000223.

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Creer, Thomas L., and Kathryn E. Gustafson. "Psychological problems associated with drug therapy in childhood asthma." Journal of Pediatrics 115, no. 5 (November 1989): 850–55. http://dx.doi.org/10.1016/s0022-3476(89)80122-2.

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Koren, Gideon. "Book Review: Problems in Pediatric Drug Therapy, 4th Edition." Annals of Pharmacotherapy 37, no. 7-8 (July 2003): 1151. http://dx.doi.org/10.1345/aph.1d046.

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Newsome, Jonathan S., and Anand Iyer. "Acceptance of pharmacist recommendations categorized by drug therapy problems." Journal of the American Pharmacists Association 52, no. 6 (November 2012): 731–32. http://dx.doi.org/10.1331/japha.2012.11130.

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Østensen, M. "Disease specific problems related to drug therapy in pregnancy." Lupus 13, no. 9 (September 2004): 746–50. http://dx.doi.org/10.1191/0961203303lu2004oa.

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Darmansjah, Iwan. "Auditing drug therapy - special problems in lessÂ developed countries." Medical Journal of Indonesia 1, no. 3/4 (December 25, 1992): 131–3. http://dx.doi.org/10.13181/mji.v1i3/4.3612.

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Morris, A. D. "Problems of multiple drug therapy in type 2 diabetes." International Journal of Clinical Practice 58 (August 27, 2004): 45–48. http://dx.doi.org/10.1111/j.1368-504x.2004.00330.x.

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Vasil’eva, I. A., A. G. Samoilova, A. E. Ergeshov, T. R. Bagdasaryan, and L. N. Chernousova. "CHEMOTHERAPY OF TUBERCULOSIS: PROBLEMS AND PERSPECTIVES." Annals of the Russian academy of medical sciences 67, no. 11 (November 10, 2012): 9–14. http://dx.doi.org/10.15690/vramn.v67i11.465.

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Challenges of tuberculosis chemotherapy under conditions of high drug resistant (DR) tuberculosis burden are discussed. Ultimate results of treatment by standard regimens of 1658 patients with new tuberculosis cases and relapses were analyzed. Favorable ultimate results were observed among both patients with new tuberculosis cases and relapses having drugs sensitivity. Efficacy of tuberculosis treatment by standard regimens of chemotherapy is decreasing as a result of DR amplification. Risk factors of unfavorable ultimate result among pulmonary tuberculosis patients are primary resistance to isoniazid (OR =2,1) and multiple drug resistance of M. tuberculosis (OR =8,0). Earlier onset of treatment and correct individual therapy with second line drugs as a result of rapid methods of DR tuberculosis diagnostics are those approaches which provide the best therapeutic effect among multiple drug resistant tuberculosis patients both in culture conversion (97,7%) and cavity closure rate (82,7%).

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Akasheva, D. U., E. S. Bulgakova, I. S. Yavelov, A. Yu Gorshkov, and O. M. Drapkina. "Elderly Patient Management Problems: Antithrombotic Therapy Selection Features. Clinical Case." Rational Pharmacotherapy in Cardiology 14, no. 4 (September 4, 2018): 515–23. http://dx.doi.org/10.20996/1819-6446-2018-14-4-515-523.

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The growing population of elderly people is the main «antithrombotic drugs consumer» because there is higher prevalence of thromboembolic diseases (acute coronary syndrome, venous thromboembolism, atrial fibrillation) among them than among younger people. Elderly people have high risks of both thromboembolic and bleeding complications associated with antithrombotic drugs using. Antithrombotic drug choice is based on individual careful estimation of the «risk/benefit» ratio. Sometimes real clinical practice gives us problems and questions, having no answers in any guidelines. Such a difficult clinical case of elderly patient management is presented in this article.

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Tellnes, Gunnar, Arild Bjørndal, and Per Fugelli. "Treatment of Mental Problems in General Practice." Scandinavian Journal of Social Medicine 15, no. 3 (September 1987): 131–37. http://dx.doi.org/10.1177/140349488701500303.

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The aim of the study was to provide a basis for improving the treatment and prevention of mental problems in a defined local community. The prescribing of psychotropic drugs has been recorded as well as the use of non-drug therapy and the factors which worsened the patients' mental problems. The rate of psychotropic drug-users was 15% for females and 9% for males. The total prescribing during one year amounted to 59 defined daily doses (DDD) per thousand inhabitants per day. Hypnotics/sedatives constituted 30%, anti-histamines 23%, neuroleptics 18%, minor tranquillizers 16%, and antidepressants 13%. About 1/4 of the psychotropic drug-users was prescribed more than 180 DDD per year, representing a risk group for chronic use. The majority of all psychotropic drugs (65%) was prescribed through indirect contacts implying a danger of developing “repeat prescription syndromes”. Less than one half of the patients who might have benefited from referral to a psychiatrist had, in fact, been referred during the previous three years. Somatic disease (among the psychotropic drug-users) and illness among other family members were frequently reported as worsening factors. This indicates the importance of holistic therapy and prophylaxis in general practice. Among our advice for prevention of mental problems to the local authorities was the arrangement of weekly social meetings and clubs for disabled pensioners and elderly people.

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Gelchu, Tamene, and Jemal Abdela. "Drug therapy problems among patients with cardiovascular disease admitted to the medical ward and had a follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital: The case of a tertiary hospital in eastern Ethiopia." SAGE Open Medicine 7 (January 2019): 205031211986040. http://dx.doi.org/10.1177/2050312119860401.

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Background: Pharmacotherapy is important in reducing morbidity and mortality related to cardiovascular diseases. However, these advantages are limited by drug therapy problems that can impact on a patient’s quality of life, prolong hospital stays, and increase the overall burden of healthcare expenditures. Therefore, this study was aimed to assess drug therapy problems among patients with cardiovascular diseases who were hospitalized and received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital. Methods: An institution-based cross-sectional study design was used to collect data from patients with cardiovascular diseases who were admitted to the medical ward and those who had received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital. The collected data were coded, entered, and analyzed using SPSS version 16. The associations of selected categorical variables were done using binary logistic and multivariate logistic regression analyses. Results: Out of 216 study participants, females accounted for 123 (57%), whereas 93 (43%) of them were males. Among cardiovascular diseases identified in the medical ward and ambulatory clinics of Hiwot Fana Specialized University Hospital, congestive heart failure 96 (44.4%) and hypertension 93 (43.1%) were the two most commonly diagnosed disorders. Of the total participants involved in the study, 131 (60.65%) had drug therapy problems. Among the seven classes of drug therapy problems assessed, the most commonly observed was the need for additional drug therapy 76 (58%); followed by cases related to unnecessary drug therapy and noncompliance both of which were estimated to be 16 (12.2%). In addition, of independent variables, only the use of more than three drugs was significantly associated in both binary logistic (crude odds ratio = 0.41, 95% confidence interval = 0.234–0.719, p = 0.002) and multivariate logistic regressions (adjusted odds ratio = 4.86, 95% confidence interval = 1.625–14.536, p = 0.005) as compared with those patients who were using less than three drugs. Conclusion: The findings of the study indicated that more than half of the study participants experienced drug therapy problems, for which 58% required additional drug therapy. The risk of drug therapy problem is found to increase with the use of more than three drugs. Since these problems are adversely affecting the treatment outcome of patients, this is an area which requires special attention and the cooperation of healthcare professionals to tackle it.

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Dinçoğlu, Hacer. "Diabetes mellitus, insulin therapy, oral antidiabetic, rational drug use." Journal of Turkish Family Physician 11, no. 3 (September 25, 2020): 131–40. http://dx.doi.org/10.15511/tjtfp.20.00331.

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Diabetes mellitus (DM); is a metabolic progressive di-sease with a rapidly increasing prevalence. The most important factors in the treatment of DM is the education of individuals with diabetes and rational drug use. Multiple insulin therapy is started with the diagnosis in type 1 DM (T1DM), oral antidiabetic drugs (OAD) and insulin treatments are initiated together according to the glycemic status in Type 2 DM (T2DM). Problems causing irrational drug use related to OAD in DM; advanced age, multidrug use, complex drug intake program, lack of knowledge, drug-related side effects, and patient disbelief. Problems causing irrational drug use related to insulin; hypoglycemia, lipodystrophy, incorrect injection technique, insufficient and high dose administration. This situation appears as macrovascular and microvascular diseases with not reaching target HbA1c values by causing glycemic dysregulation in DM. The success of the holding of treatment in optimal status with prevention for glycemia and metabolic condition raises the quality of life in patients, prolong the patient’s life expectancy and reduces costs. Doctors and insulin educators raising awareness of rational drug use in the diabetic population ensures that correct the irrational behaviors performed in the diabetic population and adopt appropriate behaviors as a lifestyle. Thus it will improve the educational content given to people with diabetes, help to improve diabetes management and behavioral change, thereby achieving appropriate glycemic goals and increasing secondary rational gains from drugs with treatment.

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McDonough, Randal P., and William R. Doucette. "Drug Therapy Management: An Empirical Report of Drug Therapy Problems, Pharmacists' Interventions, and Results of Pharmacists' Actions." Journal of the American Pharmacists Association 43, no. 4 (July 2003): 511–18. http://dx.doi.org/10.1331/154434503322226266.

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Sukhanov, V. A., A. N. Saprin, and L. A. Piruzyan. "Pharmacogenetic Problems of Antitumor Therapy (A Review)." Pharmaceutical Chemistry Journal 38, no. 7 (July 2004): 347–54. http://dx.doi.org/10.1023/b:phac.0000048430.49990.0b.

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Smith, Cynthia P., and Dale B. Christensen. "Identification and Clarification of Drug Therapy Problems by Indian Health Service Pharmacists." Annals of Pharmacotherapy 30, no. 2 (February 1996): 119–24. http://dx.doi.org/10.1177/106002809603000201.

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OBJECTIVE: To describe drug therapy problem intervention activities of Indian Health Service (IHS) pharmacists and to characterize the types of drug therapy problems encountered. DESIGN: Longitudinal descriptive study of documented potential drug therapy problems detected by pharmacists during the conduct of routine dispensing activities during a 6-month period. SETTING: All 18 IHS hospitals and ambulatory care facilities in one geographic area. MAIN OUTCOME MEASURES: Potential drug therapy problem detection rates by pharmacists and problem detection rates per 100 dispensed prescriptions are reported. Problems are characterized as to type, nature of intervention activities undertaken, and results of interventions. Changes in problem detection rate across clinics and over time are reported. RESULTS: Pharmacists detected and reported problems at a rate of slightly less than one per 100 prescriptions dispensed; however, drug therapy changes occurred 78% of the time as a result of the interventions. The types of drug therapy problems occurring most frequently were incorrect information (40.7%), prescription clarification (39.6%), clinical problems (10.4%), and inappropriate drug (9.3%). Physician acceptance of pharmacist interventions varied by type of drug therapy problem. Drug therapy changes occurred 77.7% of the time as a result of the interventions. Pharmacists at several sites used records of the drug therapy problems to make changes in policy or procedures as a part of continuous quality improvement activities. As a result, the problem detection rate declined over time in several settings. CONCLUSIONS: In comparison with other settings where cognitive services have been reported, IHS pharmacists detected fewer problems, but their interventions resulted in a higher percentage of drug therapy changes.

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Drozdov, V. N., E. V. Shikh, S. Y. Serebrova, A. G. Abrosimov, and A. K. Starodubtsev. "Alflutop - in modern symptom - modifying osteoarthritis therapy." Terapevticheskii arkhiv 91, no. 5 (May 15, 2019): 134–40. http://dx.doi.org/10.26442/00403660.2019.05.000169.

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One of the serious problems during the treatment of osteoarthritis (OA) is the developing of adverse drug events during therapy. Nonsteroidal anti - inflammatory drugs (NSAIDs) are the first drugs with the high incidence and severity of adverse events. This article describes OA treatment strategies approaches for OA are presented using the complex drug Alflutop, which has a composition similar to the human hyaline cartilage. The drug has anti - inflammatory and analgesic effects, normalizes the function of the affected joints, improves the quality of patients’ life, also has a structure - modifying effect. Such therapy is safe, well tolerable for patients, and can be used used as a starting complex OA treatment.

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Fendrikova, A. V., V. V. Skibitskiy, E. S. Garkusha, A. I. Chesnikova, and M. Е. Statsenko. "Resistant arterial hypertension: problems and opportunities for personalised drug therapy." Kuban Scientific Medical Bulletin 27, no. 5 (October 14, 2020): 60–73. http://dx.doi.org/10.25207/1608-6228-2020-27-5-60-73.

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Background. Effective drug therapy for resistant arterial hypertension is among major problems in modern medicine. The actual prevalence of resistant arterial hypertension is unknown, and its pathogenetic mechanisms are actively investigated. Among its important components is salt-sensitivity of the patient. At the same time, effi cacy of combined antihypertensive therapy in relation to salt-sensitivity of patients with resistant arterial hypertension is not fully understood.Objectives. Effi cacy assessment of personalised drug therapy in salt-sensitive and salt-resistant patients with resistant arterial hypertension.Мethods. We conducted a non-randomised controlled study with the observation time of 48 weeks. All patients had ambulatory blood pressure monitoring (ABPM) in the onset and past 48 weeks of treatment. Prior to therapy, the patient’s salt-sensitivity was determined with ABPM in salt loading (V.I. Kharchenko’s test). Two cohorts were formed with respect to the test results to include salt-sensitive (n = 67) and salt-resistant (n = 54) patients. Both cohorts received a combined therapy: enalapril 10 mg twice a day, amlodipine 10 mg/day, hydrochlorothiazide 12.5 mg/day, aliskiren 150 mg/day. If a target blood pressure was not observed in 3 weeks, aliskiren was elevated to 300 mg/day. Therapeutic effi cacy was assessed with ABPM after 48 weeks. Non-parametric statistical analysis was performed using Statistica 6.10 (StatSoftInc, USA).Results. The study included 121 patients with resistant arterial hypertension, median age 63 [58;67]. With background therapy, the target blood pressure was observed in 29 (43.4%) patients in cohort 1 and in 38 (70.4%) — in cohort 2 (intergroup p < 0.05). Statistically signifi cant lower ABPM values were registered in both cohorts after 48 weeks. Daily blood pressure normalised with therapy in 62.1% of patients in cohort 1 and in 68.4% — in cohort 2. The salt-resistant cohort exhibited a more pronounced reduction in ABPM values compared to salt-sensitive patients.Conclusion. Salt-sensitivity is a factor for personalising antihypertensive drug therapy in patients with resistant arterial hypertension due to specifi city of mechanisms for maintaining high blood pressure. Combined antihypertensive therapy with aliskiren is statistically more effective in salt-resistant than in salt-sensitive patients.

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Jankowska, Ewa A., Cristiana Vitale, Izabella Uchmanowicz, Michał Tkaczyszyn, Marcin Drozd, and Piotr Ponikowski. "Drug therapy in elderly heart failure patients." European Heart Journal Supplements 21, Supplement_L (December 1, 2019): L8—L11. http://dx.doi.org/10.1093/eurheartj/suz237.

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Abstract Although heart failure (HF) is considered as a cardiogeriatric syndrome, elderly and very elderly patients are under-represented in the vast majority of clinical trials investigating novel drugs and therapies in this population. The homoeostatic systems of elderly subjects are very fragile, and the management of HF accompanied by numerous comorbidities requires a holistic approach towards the patient, with special emphasis not only on psychosomatic problems but also on the individual (including social) needs of each particular patient, along with the support for the family and/or caregivers. In this article, we summarize current evidence regarding pharmacotherapy of elderly patients with HF and summarize the clinical problems occurring in this population.

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Monica, Cindy, Aminah S, and Siti Dalilla. "DRP EVALUASI DRUNG RELATED PROBLEMS (DRPs) ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP ANAK RUMAH SAKIT UMUM DAERAH DELI SERDANG." JURNAL FARMASIMED (JFM) 3, no. 2 (April 29, 2021): 63–68. http://dx.doi.org/10.35451/jfm.v3i2.574.

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Background: Infection is one of the top ten diseases in Indonesia, so that antibiotic therapy is quite high. The increasing use of antibiotics may lead to an increase in the use of irrational antibiotics. Drug Related Problems (DRPs) are events that are not expected from the patient's experience or are suspected to be due to drug therapy so that they have the potential to interfere with the desired healing success. Objective: This study aims to determine the number of occurrences of DRPs which include dosage inaccuracy, namely under and over dose, indication without drug, drug without indication, potential interactions and inaccuracy of drug selection in inpatient pneumonia treatment for children at the Deli Serdang Regional public hospital. In 2019 Method: This study is retrospective in which data is obtained through secondary data in the form of patient medical records for the period January-December 2019 with a cross-sectional study design. The data collection technique was in the form of total sampling, obtained 50 samples that fit the inclusion criteria. Results: Drung Related Problems (DRPs) research that occurred in the under-dose category of drugs (4.0%), and excessive drug doses (2.0%) and no DRPs (94.0%). This shows that the role of pharmacists is important in monitoring patient drug therapy to minimize the occurrence of DRPs.

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Hazen, Ankie C. M., Dorien L. M. Zwart, Judith M. Poldervaart, Johan J. de Gier, Niek J. de Wit, Antoinette A. de Bont, and Marcel L. Bouvy. "Non-dispensing pharmacists’ actions and solutions of drug therapy problems among elderly polypharmacy patients in primary care." Family Practice 36, no. 5 (January 10, 2019): 544–51. http://dx.doi.org/10.1093/fampra/cmy114.

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Abstract Objective To evaluate the process of clinical medication review for elderly patients with polypharmacy performed by non-dispensing pharmacists embedded in general practice. The aim was to identify the number and type of drug therapy problems and to assess how and to what extent drug therapy problems were actually solved. Method An observational cross-sectional study, conducted in nine general practices in the Netherlands between June 2014 and June 2015. On three pre-set dates, the non-dispensing pharmacists completed an online data form about the last 10 patients who completed all stages of clinical medication review. Outcomes were the type and number of drug therapy problems, the extent to which recommendations were implemented and the percentage of drug therapy problems that were eventually solved. Interventions were divided as either preventive (aimed at following prophylactic guidelines) or corrective (aimed at active patient problems). Results In total, 1292 drug therapy problems were identified among 270 patients, with a median of 5 (interquartile range 3) drug therapy problems per patient, mainly related to overtreatment (24%) and undertreatment (21%). The non-dispensing pharmacists most frequently recommended to stop medication (32%). Overall, 83% of the proposed recommendations were implemented; 57% were preventive, and 35% were corrective interventions (8% could not be assessed). Almost two-third (64%) of the corrective interventions actually solved the drug therapy problem. Conclusion Non-dispensing pharmacists integrated in general practice identified a large number of drug therapy problems and successfully implemented a proportionally high number of recommendations that solved the majority of drug therapy problems.

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Patel, Mira, Michael Campbell, Mobeen Moslem, Preston Spriggel, and Terri Warholak. "Identifying Drug Therapy Problems Through Patient Consultation at Community Pharmacies." Journal of Patient Safety 16, no. 1 (March 2020): 19–23. http://dx.doi.org/10.1097/pts.0000000000000228.

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Robertson, Kenneth E., Steven J. Hultgren, and Richard H. Rhodes. "Staff development program for identifying and resolving drug therapy problems." American Journal of Health-System Pharmacy 53, no. 18 (September 15, 1996): 2194–96. http://dx.doi.org/10.1093/ajhp/53.18.2194.

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Astuti, Diany, Retnosari Andrajati, and Sudibyo Supardi. "INFLUENCE OF PHARMACIST–DOCTOR COMMUNICATION ON PEDIATRIC ANTIBIOTIC PRESCRIPTIONS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 17 (October 1, 2017): 46. http://dx.doi.org/10.22159/ajpcr.2017.v10s5.23093.

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Objectives: The purpose of the research was to describe drug-related issues and assess the effect of communication between pharmacists and physicians on decreased prescription drug-related problems in pediatric antibiotics.Methods: Intervention was carried out in the form of pharmacist discussing information-related issues about drugs with physicians prescribing antibiotics to pediatric patients. The research sample included 338 prescription sheets on pediatric outpatient use of antibiotics, and a prospective design was used. Analysis of the data was carried out in the form of a frequency distribution and bivariate analysis Wilcoxon test.Results: The results showed that drug-related problems were recorded on 62.22% of the 338 prescription sheets. The biggest problems that occurred had to do with the effectiveness of therapy (P1; 79.3%) and cost issues (P1; 20.7%). In terms of P1, drug-related problems involved excessive frequency of drug administration (80.1%), inappropriate drug dose selection (17.2%), drug interactions (9.6%), inadequate drug selection (12.2%), a subtherapeutic dose (4.1%), and excessive drug dose (0.5%). For P1, therapy cost problems were a lack of indication for the drug (84.1%) and improper drug selection (15.9%).Conclusions: The influence of pharmacist–physician communication concerning the reduction of drug-related problems for pediatric outpatient prescriptions was statistically significant (p<0.05). Ultimately, communication between pharmacists and physicians can reduce drug-related problems by 22.9%.

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P, Manikandan, and Sundara Ganapathy R. "NANOEMULSIONS FOR PROSTRATE CANCER THERAPY: AN OVERVIEW." Asian Journal of Pharmaceutical and Clinical Research 10, no. 5 (May 1, 2017): 37. http://dx.doi.org/10.22159/ajpcr.2017.v10i5.17307.

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The objective of this review is to focus the inferences of low/poor bioavailability and lack of dose proportionality for the oral delivery of drugs in prostatecancer therapy. To overcome such problems, various formulation strategies has been reported including various methods for the use of surfactants,cyclodextrins, solid dispersions, micronization, permeation enhancers, and lipids. Flutamide is an antiandrogen drug and used for the therapy of prostate cancer. The flutamide drug is having limited clinical application due to its poor water solubility and needs enhancement of its dissolution rate in simulated gastric fluids. The lipid-based formulations such as nanoemulsion have been shown to improve the solubility and oral absorption of lipophilic drugs. To conclude, this article emphasizes the various approaches of nanoemulsion based formulation for prostate cancer therapy.Keywords: Nanoemulsion, Prostate cancer, Flutamide, Antiandrogen drug, Lipophilic drugs.

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Schneider, A., A. Wagner, E. E. Davydova, A. S. Smirnov, I. N. Glazkov, M. M. Shegai, and D. V. Glazkova. "Problems and Prospects of Gene Therapy Against HIV." Pharmaceutical Chemistry Journal 47, no. 12 (March 2014): 627–35. http://dx.doi.org/10.1007/s11094-014-1023-9.

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Gardner, Marie E. "Drug Therapy of Aggressive Behaviors Accompanying Dementia." Journal of Pharmacy Practice 8, no. 5 (October 1995): 194–207. http://dx.doi.org/10.1177/089719009500800503.

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Aggressive behaviors often accompany dementia in the elderly, institutionalized patient. These may include any number of verbal or physical acts, and range from swearing, threatening, to harming self, others, or property. Identifying specific target behaviors for treatment is important in selecting the appropriate therapeutic option. The major neurotransmitters involved in aggression include gamma-aminobutyric acid (GABA) and serotonin, which inhibit aggression, and dopamine, norepinephrine and acetylcholine, which increase it. Drug therapy for control of aggressive behaviors has traditionally included the antipsychotics and benzodiazepines. However, additional, newer therapies are also useful. Among these are the anticonvulsants carbamazepine and valproic acid, various beta-blocking agents, antidepressants, and buspirone. These medications may be needed when nondrug therapy for control of behavioral problems fails or is insufficient. Determining which behaviors are problematic and need treatment, knowing which medications are indicated for those problems, and noting contraindications for particular drug therapies will lead to the best therapeutic option for a given patient.

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Amorha, Kosisochi Chinwendu, Anthony Chukwuma Onu, Chigozie Gloria Anene-okeke, and Chinwe Victoria Ukwe. "EVALUATION OF DRUG THERAPY PROBLEMS IN ASTHMA PATIENTS RECEIVING CARE IN TWO HOSPITALS IN SOUTH-EASTERN NIGERIA." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 2 (February 1, 2018): 50. http://dx.doi.org/10.22159/ijpps.2018v10i2.22472.

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Objective: To evaluate drug therapy problems in asthma patients visiting a secondary and tertiary hospital in South-Eastern Nigeria.Methods: This study was a retrospective, cross-sectional analyses of the medical records of adult asthmatic patients receiving care in two hospitals in Enugu State, within a 15-year period. The Pharmaceutical Network Care Europe (PCNE) tool version 6.2 was used to assess drug therapy problems. The IBM Statistical Product for Services Solution (SPSS) version 20.0 was used for analysis. For all results, P ≤ 0.05 was considered statistically significant.Results: Majority of the patients were below 60 y old (81.2%); female (68.8%) and were on more than two drugs (95.3%). Majority of the identified drug therapy problems (DTPs) were adverse reactions (65.7%). The inappropriate drug combination was the major cause of DTPs (65.6%). Only about 23.4% of the intervention outcomes were known. University of Nigeria Teaching Hospital (UNTH) had more interventions (35.9%) than Medical Centre (8.0%) (χ2 = 6.323; df = 1; **P = 0.012); and more of the outcomes of their interventions known (38.5%) compared to Medical Centre (0.0%) (χ2 = 12.559; df = 1; **P ˂ 0.001).Conclusion: Adverse reactions and inappropriate drug selection were the major identified DTPs and major cause of DTPs, respectively. Most DTPs had no interventions. The documented interventions included stopping of the drugs, change of drugs or dosage, change of instructions for use and starting of new drugs. Most interventions had unknown outcomes. UNTH had more interventions with known outcomes than the University of Nigeria Medical Centre.

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Pemmasani, Deepishka, Sai Deepak Gali, Maanasa Arcot, and Durga Prasad T. S. "Assessment of drug related problems and clinical pharmacist interventions in paediatric department of a tertiary care teaching hospital." International Journal of Basic & Clinical Pharmacology 7, no. 10 (September 24, 2018): 1934. http://dx.doi.org/10.18203/2319-2003.ijbcp20183926.

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Background: Drug-related problems (DRPs) are frequent in hospitalization in pediatrics. The main aim of present investigation is to assess drug related problems and clinical pharmacist interventions in pediatric department of tertiary care hospital.Methods: It was a prospective, observational and interventional study carried over a period of 6 months.Results: A total of 66 patients were identified with drug related problems. Among them 31 (42%) were in between 1month–2 years followed by 25 (34%) were in between 2-11 years, 10(24%) were in between 11-18 years of age. 30(45.3%) patients were prescribed with 0-3 drugs followed by 21 (31.3%) were prescribed with 3-5 drugs, 15(23.3%) were prescribed with 6-10 drugs. Most of the DRP’s observed in the study were drug interactions 52(78.78%) [major-19 (36.53%), moderate-27 (5192%) and minor-6(11.53%)] followed by adverse drug reactions 12 (18.18%), and duplication errors were 2 (3.03%). Majority of the clinical pharmacist recommendations were duration change 52 (34.66%), drug change 10(6.66%), dose reduction 2 (1.35%) followed by drug termination 2 (1.33%). Major significance of DRPs were noted high 31(57.96%), whereas 25 (39.8%) were moderate and 8 (12.12%) were minor. The acceptance rate of intervening clinical pharmacist recommendation and change in drug therapy was found to be high in 57 (86.66%) cases while in 9 (13.33%) cases suggestions were accepted but therapy was not changed. There were no cases with neither suggestion were accepted nor therapy changed.Conclusions: Clinical pharmacist involvement in inpatient pediatric care can significantly help to identify, resolve and prevent the drug related problems. The study concluded that the clinical pharmacist has a significant role in patients care at hospital.

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Journal articles on the topic 'Drug therapy problems'

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