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1

Lee, Martin, and Simon George. "Drug Strategy Unit." British Journal of Forensic Practice 7, no. 4 (2005): 39–48. http://dx.doi.org/10.1108/14636646200500028.

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2

Hamidy, M. Yulis, and Dina Fauzia. "SIGNIFICANT DRUG INTERACTIONS AMONG INTENSIVE CARE UNIT PATIENTS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 14 (2017): 35. http://dx.doi.org/10.22159/ajpcr.2017.v10s2.19482.

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Objective:Drug interaction is one factor that contributes to drug-related problems. The hospitalized patients in intensive care units (ICU) have a higher risk for developing drug interactions. The purpose of this study was to evaluate the potency of significantdrug interactions in ICU patients.Methods:Drug-drug interactions from patient's medical records from ICU of Arifin Achmad General Hospital in Pekanbaru, Province of Riau, Indonesia at period July to December 2015 wereassessed. Drug Interaction Checker (Medscape) software was used to identify potential drug interactions.Results: This stud
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3

Aziz, Muhammad Tahir. "Drug Interaction Exposures in an Intensive Care Unit: AntihypertensivePopulation." Journal of Applied Pharmacy 7 (2015): 41. http://dx.doi.org/10.21065/19204159.7.41.

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Drug-drug interaction is an event that occurs when the effects of one drug modified by another drug or food when taken concurrently or concomitantly. This interaction either reduced the effect or no effect or increased drug effect. Patient in intensive care unit (ICU) are highly susceptible to drug interactions because of the complexity of the drugs regimens they receive. Drugs may affect the Pharmacokinetics of the critical ill patients and subsequently altered the pharmacological response, which potentially lead to serious adverse drug events. Drug-drug interaction (DDI) are considered predi
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4

Schachtsiek, Thomas, Jona Voss, Maren Hamsen, Beate Neumann, Hans-Georg Stammler, and Norbert Sewald. "Cryptophycin unit B analogues." Beilstein Journal of Organic Chemistry 21 (March 7, 2025): 526–32. https://doi.org/10.3762/bjoc.21.40.

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Drug conjugates using toxic payloads are a promising approach for selectively combating cancer while sparing healthy tissue. The lack of highly cytotoxic and at the same time selective therapeutics against cancer is an ongoing challenge. Cryptophycins are a class of cyclic depsipeptides renowned for their high cytotoxicity in the picomolar range often combined with efficacy against multidrug-resistant tumour cell lines. However, cryptophycins failed as stand-alone drugs in cancer treatment, and their naturally occurring derivatives lack a covalent attachment handle. By making use of drug conju
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5

Dasta, Joseph F. "Drug Use in a Surgical Intensive Care Unit." Drug Intelligence & Clinical Pharmacy 20, no. 10 (1986): 752–56. http://dx.doi.org/10.1177/106002808602001002.

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A retrospective review of drug usage in 180 patients admitted to a surgical intensive care unit was conducted. The average stay was three days and the total and daily number of drugs averaged 7.6 and 5.6, respectively. The most common drug class used was antibiotics, with cefazolin being the most commonly used antibiotic. Other commonly used drugs include analgesics, diuretics, H2-antagonists, vasoactive drugs and inotropes, antacids, and antiarrhythmics. This study indicates that patients admitted to a surgical intensive care unit are exposed to a variety of potent drugs, often given in combi
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6

O'Rourke, M. M., and J. A. Taylor. "Referrals to a Scottish Drug Dependence Unit." British Journal of Psychiatry 151, no. 2 (1987): 240–43. http://dx.doi.org/10.1192/bjp.151.2.240.

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The social and demographic characteristics, drug history and current levels of drug taking, drug-related illnesses, and criminal records of a one year cohort of attenders at the Southern General Hospital are described. The findings are compared with those of previous studies at the same clinic; made when methadone was prescribed for a limited period in reducing dosage and when this policy was being replaced by one of the use opiate-free drugs to cover withdrawal.
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7

Vasic, Karin, Zorica Jovic, and Gordana Pesic. "Control of antibiotic use by a unit-dose drug distribution system." Open Medicine 2, no. 2 (2007): 168–79. http://dx.doi.org/10.2478/s11536-007-0023-5.

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AbstractThe aim of the study was to test a new model of drug distribution known as unit-dose drug distribution including the effects of implementing this system on total drug consumption, especially in curbing antimicrobial use.The study was carried out in the Department of Surgery at the University Clinical Center in Nis, Serbia. During the first six months of the study (comparative period), drugs were delivered directly from the pharmacy to the urology and orthopedic wards in the traditional way (ward stock system). During the next six months (study period), drugs were delivered directly fro
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8

Nishimiya, Yusuke, Toshimitsu Konuma, Ken Tasaka, and Toshiaki Sendo. "Drug interaction (24. drug-drug interactions in intensive care unit)." Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 124, no. 2 (2012): 167–73. http://dx.doi.org/10.4044/joma.124.167.

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9

Stockley, David. "National Drugs Intelligence Unit." Police Journal: Theory, Practice and Principles 61, no. 4 (1988): 295–303. http://dx.doi.org/10.1177/0032258x8806100402.

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Served 3–1/2 years as Deputy Head of the Metropolitan Police Central Drug Squad. During this time he was seconded to the Bahamas (between November 1983 and July 1984) as an investigator to assist a Commission of Inquiry into drug trafficking from South America to the USA using the Bahamas as a transhipment point. The inquiry also included investigating allegations of involvement by public officials including members of the Bahamian Government. He was promoted Detective Chief Superintendent in April 1986 and has since served in the National Drugs Intelligence Unit during the major part of its d
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10

Fortunandha, Dhea Keyle, Arih Diyaning Intiasari, and Arif Kurniawan. "Analisis Perencanaan Obat di UPTD Farmasi Dinas Kesehatan Kota Depok." Jurnal Penelitian dan Pengembangan Kesehatan Masyarakat Indonesia 2, no. 1 (2021): 60–66. http://dx.doi.org/10.15294/jppkmi.v2i1.47251.

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Background: Planning is an initial stage and as an important and decisive stage, because planning for drug needs will affect the next cycle of drug management in the health care unit. If the planning are weak, it will give a negative impact on the overall management cycle. The findings of expired drugs is a negative impact experienced by the Pharmaceutical Technical Service Unit of Government Health Department in Depok, so it can be assumed that drug planning has not been carried out properly.
 Methods: This research is a qualitative research with a case study design. This research was co
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11

Talley, C. Richard. "Whither unit dose drug distribution?" American Journal of Health-System Pharmacy 51, no. 15 (1994): 1879. http://dx.doi.org/10.1093/ajhp/51.15.1879.

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12

Gillam, S., F. Dubois-Arber, L. Stirzacker, A. Croft, and N. Das Gupta. "Evaluating the drug dependency unit." Public Health 106, no. 3 (1992): 209–15. http://dx.doi.org/10.1016/s0033-3506(05)80538-4.

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13

Rick Mullin. "Cambrex sells finished-drug unit." C&EN Global Enterprise 101, no. 38 (2023): 11. http://dx.doi.org/10.1021/cen-10138-buscon1.

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14

Vo, Tam Thuy Lu, Dain Shin, Eunyoung Ha, and Ji Hae Seo. "Dysfunction of the Neurovascular Unit by Psychostimulant Drugs." International Journal of Molecular Sciences 24, no. 20 (2023): 15154. http://dx.doi.org/10.3390/ijms242015154.

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‘Drug abuse’ has been recognized as one of the most pressing epidemics in contemporary society. Traditional research has primarily focused on understanding how drugs induce neurotoxicity or degeneration within the central nervous system (CNS) and influence systems related to reward, motivation, and cravings. However, recent investigations have increasingly shifted their attention toward the detrimental consequences of drug abuse on the blood–brain barrier (BBB). The BBB is a structural component situated in brain vessels, responsible for separating brain tissue from external substances to main
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15

PERLMAN, SHARON A. "SI Unit Dangers." Pediatrics 83, no. 5 (1989): 804. http://dx.doi.org/10.1542/peds.83.5.804.

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The recent commentary concerning SI units by the American Academy of Pediatrics' Committee on Drugs (Pediatrics 1989;83:129-131) pointed out some of the difficulties associated with conversion of drug concentrations to SI units. As further evidence of the potential dangers inherent in changing to a system of molar units, I would like to point out two errors, presumably typographical, in that very report. First, the statement was made that "a 125-mg tablet of erythromycin would become a 0.1703-mg tablet"; I believe a 0.1703-mmol tablet was intended.
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16

Al-Zaru, Ibtisam M., Anas Mohammad, and Anas J. Almutlaq. "Effectiveness of an Educational Program Regarding Vasoactive Drugs at the Level of Knowledge and Practices among Nurses Working in Critical Care Units." Jordan Journal of Nursing Research 1, no. 2 (2022): 4–15. http://dx.doi.org/10.14525/jjnr.v1i2.02.

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Background: Critical care-unit nurses have the responsibility of medication preparation and administration. Vasoactive drugs are lifesaving drugs that are commonly used in critical-care units. However, the inappropriate administration of vasoactive drugs may lead to poor patient outcomes and complications. Purpose: The present study aimed to evaluate the effectiveness of an educational program of vasoactive-drug administration in critical care-unit nurses' knowledge and practice. Methods: A one-group pre-test-post-test design was used for this study. A convenience sample of 102 registered nurs
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17

Leal, Karla Dalliane Batista, Ramon Weyler Duarte Leopoldino, Rand Randall Martins, and Lourena Mafra Veríssimo. "Potential intravenous drug incompatibilities in a pediatric unit." Einstein (São Paulo) 14, no. 2 (2016): 185–89. http://dx.doi.org/10.1590/s1679-45082016ao3723.

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ABSTRACT Objective To investigate potential intravenous drug incompatibilities and related risk factors in a pediatric unit. Methods A cross-sectional analytical study conducted in the pediatric unit of a university hospital in Brazil. Data on prescriptions given to children aged 0-15 years from June to October 2014 were collected. Prescriptions that did not include intravenous drugs and prescriptions with incomplete dosage regimen or written in poor handwriting were excluded. Associations between variables and the risk of potential incompatibility were investigated using the Student’s t test
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18

Xuan, Ping, Lianfeng Zhao, Tiangang Zhang, Yilin Ye, and Yan Zhang. "Inferring Drug-Related Diseases Based on Convolutional Neural Network and Gated Recurrent Unit." Molecules 24, no. 15 (2019): 2712. http://dx.doi.org/10.3390/molecules24152712.

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Predicting novel uses for drugs using their chemical, pharmacological, and indication information contributes to minimizing costs and development periods. Most previous prediction methods focused on integrating the similarity and association information of drugs and diseases. However, they tended to construct shallow prediction models to predict drug-associated diseases, which make deeply integrating the information difficult. Further, path information between drugs and diseases is important auxiliary information for association prediction, while it is not deeply integrated. We present a deep
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19

Shakir, Saad, and Lynda Wilton. "Drug Safety Research Unit and pharmacoepidemiology." International Journal of Pharmaceutical Medicine 14, no. 1 (2000): 1–2. http://dx.doi.org/10.2165/00124363-200002000-00001.

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20

Farmer, Roger. "The University College Drug Dependence Unit." Addiction 83, no. 4 (1988): 447–48. http://dx.doi.org/10.1111/j.1360-0443.1988.tb00498.x.

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21

Moran, Nuala. "UK drug discovery unit takes shape." Nature Medicine 1, no. 12 (1995): 1229. http://dx.doi.org/10.1038/nm1295-1229.

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22

Clark, Alan B., and Charles C. Clark. "Sampling of Multi-Unit Drug Exhibits." Journal of Forensic Sciences 35, no. 3 (1990): 12877J. http://dx.doi.org/10.1520/jfs12877j.

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23

Spriet, Alain, and Thérèse Dupin-Spriet. "Audit of a Drug Safety Unit." Drug Information Journal 28, no. 4 (1994): 1181–86. http://dx.doi.org/10.1177/009286159402800444.

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24

Adade, Casimir A., Majda Benabbes, Mohammed J. Belahcen, and Younes Rahali. "Centralization impact and cost-saving study in a Moroccan hospital’s centralized unit of chemotherapy preparation." Journal of Oncology Pharmacy Practice 26, no. 7 (2020): 1630–36. http://dx.doi.org/10.1177/1078155220901336.

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Purpose The purpose of this study was to assess the cost saved and the amount of drug wasted when compounding anticancer drugs in the centralized unit for chemotherapy preparation. A secondary objective was to estimate the centralization impact of activities related to the preparation of chemotherapies. Methods This was a two-month, single-centre, prospective study conducted at the National Oncology Institute in Rabat. The cost saved and the amount of drug wasted were calculated using a standardized data collection sheet (the prescribed dose, the amount of drug deployed, the amount remaining a
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25

김지나, 이영미, 인용원, 박효정, and 박수진. "Evaluation of Drug-Drug Interaction in Pediatric Intensive Care Unit." Journal of Korean Society of Health-System Pharmacists 33, no. 2 (2016): 122–29. http://dx.doi.org/10.32429/jkshp.2016.33.2.002.

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26

Randhawa, Mohammad A., Hatem O. Qutub, Mastour S. Alghamdi, Raniah A. Al-Jaizani, Rayan Y. Mushtaq, and Mohammad J. Akbar. "Drug Related Problems at the Intensive Care Unit of a University Hospital in Saudi Arabia." Saudi Journal of Internal Medicine 5, no. 1 (2015): 11–18. http://dx.doi.org/10.32790/sjim.2015.5.1.3.

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Background: Medication errors can lead to mild or severe drug related problems. Drug related problems are sometimes unpredictable and can occur without medication errors. Awareness and identification of medication errors and drug related problems aids in adoption of measures to prevent and treat them.
 Objective: Present study aimed to find out prevalence of drug related problems reporting or occurring at Intensive Care Unit of King Fahd Hospital of the University, Alkhobar, Saudi Arabia.
 Methods: Scrutinizing written files of all patients reporting to Intensive Care Unit, from Janu
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27

Wootton, R., and F. Henderson. "Rationalization and computerization of the drug supply to an animal unit." Laboratory Animals 21, no. 4 (1987): 283–88. http://dx.doi.org/10.1258/002367787781363363.

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Drug stocks in an animal unit were rationalized by discarding out-of-date or unwanted items and drawing up an approved stock list. A computerized system of stock control which enables a regular and accurate inventory of pharmaceuticals to be made was then established. In addition, the paperwork required for re-ordering drugs is produced automatically. Pharmaceuticals to a total value of £1650 were discarded during the rationalization phase. The value of drugs stocked in the animal unit then stabilized at about one-third of previous levels. In the first 6 months of operation of the new system d
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Kaur, Sharonjeet, Sujit Rajagopalan, Navjot Kaur, et al. "Drug Utilization Study in Medical Emergency Unit of a Tertiary Care Hospital in North India." Emergency Medicine International 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/973578.

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Objective. To generate data on the drug utilization pattern and cost of drug treatment and to determine the rationality of prescriptions.Methods. A retrospective cross-sectional drug utilization study was conducted in the medical emergency unit of our hospital. Patient case records were reviewed to extract data on the pattern of drug use. Cost of drug treatment for the emergency visit was calculated by referring to the cost mentioned in Monthly Index of Medical Specialties and the rationality of prescriptions was evaluated using WHO core indicators of drug utilization.Results. 1100 case record
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CHIU, PO-LIN, CHUNG-YUO WU, JENHO TSAO, and FU-HSIUNG CHANG. "DRUG DELIVERY THROUGH LIPOSOME BY ULTRASONIC CAVITATION." Biomedical Engineering: Applications, Basis and Communications 13, no. 01 (2001): 47–52. http://dx.doi.org/10.4015/s1016237201000078.

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Ultrasonic cavitation has found potential usages in medical applications, and we are developing a new drug delivery control system based on liposome and cavitation technology. In order to reduce the side effects of drugs and increase the efficacy of drugs, we combine the advantage of the usage of liposome and ultrasonic cavitation to attain the system. In this system, imaging unit and power unit are essential elements. There are many parameters which need to be controlled. By this drug delivery system, we are to verify its safety and availability. In this paper, we describe how this drug deliv
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Amit Jain, Shashikant Dhir, and Satinder Kaur Sandhu. "Use of off-label drugs in the neonatal intensive care unit in India." International Journal of Basic & Clinical Pharmacology 12, no. 3 (2023): 481–88. http://dx.doi.org/10.18203/2319-2003.ijbcp20231132.

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Background: Off-label use of drugs is widespread in pediatrics and almost all neonates hospitalized in NICU are affected by the use of off-label drugs regardless of gestational age and birth weight. This is because of the lack of regulation for medications in the neonatal population and the delays in updating drug instructions. This is mainly due to the ethical difficulty in the research and difficulties in conducting clinical trials in this vulnerable population. Hence, the study was planned to assess the extent of the use of off-label drugs in the NICU. Methods: An observational study was ca
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Manogna Narne, Hema, Geethika Reddy Battula, Sushanth Sekhar Kadali, Vintha Yaswanth Reddy, and Pattan Ayubkhan Khan. "Appraisal of Drug Utilization Pattern in Intensive Care Unit: A Retrospective Study." International Journal of Science and Research (IJSR) 10, no. 11 (2021): 993–95. https://doi.org/10.21275/sr211118143418.

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32

Ronaldson, Patrick T., Erica I. Williams, Robert D. Betterton, Joshua A. Stanton, Kelsy L. Nilles, and Thomas P. Davis. "CNS Drug Delivery in Stroke: Improving Therapeutic Translation From the Bench to the Bedside." Stroke 55, no. 1 (2024): 190–202. http://dx.doi.org/10.1161/strokeaha.123.043764.

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Drug development for ischemic stroke is challenging as evidenced by the paucity of therapeutics that have advanced beyond a phase III trial. There are many reasons for this lack of clinical translation including factors related to the experimental design of preclinical studies. Often overlooked in therapeutic development for ischemic stroke is the requirement of effective drug delivery to the brain, which is critical for neuroprotective efficacy of several small and large molecule drugs. Advancing central nervous system drug delivery technologies implies a need for detailed comprehension of th
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33

Chojeta, Dariusz, Iwona Smarz-Widelska, and Malgorzata M. Koziol. "Pathogen profile of urinary tract infections in Nephrology Unit." Current Issues in Pharmacy and Medical Sciences 34, no. 4 (2021): 201–5. http://dx.doi.org/10.2478/cipms-2021-0036.

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Abstract Introduction. Urinary tract infection (UTI) is one of the most common types of infection in both hospitalized and outpatient settings. The etiology is mostly bacterial, and the typical causative agent is uropathogenic Escherichia coli. There is a noticeable increase in drug resistance of pathogenic microorganisms. The aim of the study was retrospective analyses of etiological agents of UTI and their antibiotic resistance patterns in Nephrology Unit patients. Material and methods. An infection was diagnosed based on the patient’s symptoms and positive results of urine culture, carried
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34

Can, Aylin, and E. Hilal Yayan. "Knowledge and Practices of Nurses Working in Intensive Care on Drug-Drug Interaction." Journal of Scientific Research in Medical and Biological Sciences 3, no. 3 (2022): 27–35. http://dx.doi.org/10.47631/jsrmbs.v3i3.548.

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Purpose:This study was conducted to examine the knowledge and practices of nurses working in the intensive care unit about drug-drug interaction. Materials and Methods: This study was conducted with 186 intensive care nurses working in shifts in 12 intensive care units. "Nurse information form", "Drug-drug interaction questionnaire" prepared by the researcher, and "nurse observation form" were used in data collection. The data obtained from the study were evaluated in computer environment using frequency, percentage distribution and Chi-square test. Results:In the study, 76.3% of the nurses wo
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Binmingham, Karen. "Marsden opens Europe’s largest drug development unit." Cancer Nursing Practice 4, no. 2 (2005): 4. http://dx.doi.org/10.7748/cnp.4.2.4.s2.

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36

Berthoux, Émilie, Claire Dufour, Emmanuel Raharisondraibe, and Marc Bonnefoy. "Preventable drug events in acute geriatric unit." Gériatrie et Psychologie Neuropsychiatrie du Viellissement 11, no. 1 (2013): 15–20. http://dx.doi.org/10.1684/pnv.2013.0399.

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37

Vipeesh, P., and N. J. R. Muniraj. "Controller Design for Automated Drug Delivery Unit." i-manager's Journal on Electronics Engineering 2, no. 4 (2012): 8–13. http://dx.doi.org/10.26634/jele.2.4.1898.

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BORMAN, STU. "Protruding unit key to cancer drug mechanism." Chemical & Engineering News 75, no. 24 (1997): 12–13. http://dx.doi.org/10.1021/cen-v075n024.p012.

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39

Romac, Diane R., and Timothy E. Albertson. "DRUG INTERACTIONS IN THE INTENSIVE CARE UNIT." Clinics in Chest Medicine 20, no. 2 (1999): 385–99. http://dx.doi.org/10.1016/s0272-5231(05)70148-9.

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40

Keller, Frieder. "Drug use in the intensive care unit." Kidney International 82, no. 8 (2012): 936. http://dx.doi.org/10.1038/ki.2012.286.

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Hudecz, Ferenc, Judit Reményi, Rita Szabó, et al. "Drug targeting by macromolecules without recognition unit?" Journal of Molecular Recognition 16, no. 5 (2003): 288–98. http://dx.doi.org/10.1002/jmr.639.

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Silva, Waltemberg Moreira da, Regina Cláudia Melo Dodt, Rhanna Emanuela Fontenele Lima de Carvalho, Amaurilio Oliveira Nogueira, Luis Gustavo Oliveira Farias, and Edna Maria Camelo Chaves. "Implications of antibacterial scheduling in newborns in clinical nursing practice." Revista da Rede de Enfermagem do Nordeste 16, no. 6 (2015): 809. http://dx.doi.org/10.15253/2175-6783.2015000600006.

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Objective: to identify drug associations related to the scheduling of antibiotics in the neonatal unit which may cause drug interactions. Methods: a retrospective documentary study using medical records of newborns admitted into the neonatal unit. The sample was composed of 92 newborn medical records. Data were collected through forms and presented in tables and figures. Results: associations in drug scheduling leading to pharmacokinetic interactions were found in 24 medical records, highlighting associations between amikacin and ampicillin, cefepime and furosemide, and vancomycin and furosemi
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Karve, Ashwini V., and Mayur M. Chaure. "A study comparing the change in drug utilization pattern in medical intensive care unit of a tertiary care hospital in seven years." International Journal of Basic & Clinical Pharmacology 12, no. 5 (2023): 694–98. http://dx.doi.org/10.18203/2319-2003.ijbcp20232566.

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Background: Medical intensive care unit is a type of intensive care unit that takes care of a range of medical illnesses with patients who are seriously ill and/or suffer from severe chronic illnesses. These patients are usually prescribed multiple drugs. Use of antimicrobial agents and injectable medications in setting of MICU is high as compared with other class of drugs and other hospital settings respectively. Periodic evaluation of drug utilization pattern needs to be done to enable suitable modifications in prescription of drugs to increase the therapeutic benefit and decrease the advers
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Nadigoti, Jagadeesh, and Shayeda. "Floating Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 3 (2009): 595–604. http://dx.doi.org/10.37285/ijpsn.2009.2.3.2.

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Management of illness through medication is entering a new era in which growing number of novel drug delivery systems are being employed and are available for therapeutic use. Oral sustained release gastro-retentive dosage forms (GRDFs) offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication. Floating Drug Delivery Systems (FDDS) is one amongst the GRDFs used to achieve prolonged gastric residence time. Multiple unit FDDS avoid “all-or-nothing” gastric emptying nature
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Rajesh Asija, Babulal Choudhary, and Anil Kumar Goyal. "Floating Drug Delivery System- A Review." Tropical Journal of Pharmaceutical and Life Sciences 10, no. 6 (2023): 96–100. https://doi.org/10.61280/tjpls.v10i6.152.

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Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, approaches
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Shivangi Patidar, Gaurav Goyanar, Nirmal Dongre, and Raghvendra Dubey. "Integrating multiple-unit pellet system and gastro-retentive drug delivery systems: A new era in oral drug delivery." World Journal of Biology Pharmacy and Health Sciences 20, no. 2 (2024): 514–24. http://dx.doi.org/10.30574/wjbphs.2024.20.2.0898.

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Delivery Systems (GRDDS) are advanced pharmaceutical formulations designed to extend the residence time of drugs in the gastrointestinal (GI) tract, thereby enhancing the bioavailability of medications, particularly those with narrow absorption windows or significant first-pass metabolism. By improving drug solubility and absorption, GRDDS offers a strategic approach to optimizing therapeutic outcomes. Meanwhile, Multiple-Unit Pellet Systems (MUPS) utilize a multiparticulate design consisting of small, spherical pellets that enhance the pharmacokinetic and pharmacodynamic profiles of drugs, pr
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Miyasaka, Lincoln Sakiara, and Alvaro Nagib Atallah. "Risk of drug interaction: combination of antidepressants and other drugs." Revista de Saúde Pública 37, no. 2 (2003): 212–15. http://dx.doi.org/10.1590/s0034-89102003000200008.

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OBJECTIVE: To assess the frequency of combination of antidepressants with other drugs and risk of drug interactions in the setting public hospital units in Brazil. METHODS: Prescriptions of all patients admitted to a public hospital from November 1996 to February 1997 were surveyed from the hospital's data processing center in São Paulo, Brazil. A manual search of case notes of all patients admitted to the psychiatric unit from January 1993 to December 1995 and all patients registered in the affective disorders outpatient clinic in December 1996 was carried out. Patients taking any antidepress
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48

Vaghela, Jayeshkumar P., and Anupama Sukhlecha. "Drug utilization study in neonatal intensive care unit of a tertiary care teaching hospital." International Journal of Basic & Clinical Pharmacology 6, no. 10 (2017): 2510. http://dx.doi.org/10.18203/2319-2003.ijbcp20174386.

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Background: Sick and pre-term neonates are admitted in neonatal intensive care units (NICU) and treated. A great care needs to be taken to use drugs in neonates due to the immaturity of their body functions. There is a lack of standard drug prescribing guideline in children, especially neonates because; safety and efficacy for a majority of drugs have not been established in them. The objectives of the study were to evaluate the drug utilization pattern in NICU of a teaching hospital and to identify problems in drug utilization and suggest measures, if needed.Methods: A prospective, observatio
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Anisha, Gulhane Dr. Bhushan Bhoyar*. "A Review on Multi-Unit Particulate System: Advanced Technology for Novel Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 780–89. https://doi.org/10.5281/zenodo.15597547.

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Pellets are agglomerates of fine powders or granules of bulk drugs and excipients typically ranging from about 0.5 to 1.5 mm. Multi-unit Particulates System technology refers to a pharmaceutical formulation approach in which a single dosage form, such as a tablet or capsule, contains multiple small, discrete pellets or granules. Each pellet acts as an individual drug delivery unit, often coated with one or more layers that control the release rate of the active pharmaceutical ingredient. Multi-Unit Particulate System consists of embedding many small pellet within one formulation. Types of Mult
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50

Aleksic, Dejan Z., Slobodan M. Jankovic, Milos N. Mlosavljevic, Gordana L. Toncev, Svetlana D. Miletic Drakulic, and Srdjan M. Stefanovic. "Potential drug-drug interactions in acute ischemic stroke patients at the Neurological Intensive Care Unit." Open Medicine 14, no. 1 (2019): 813–26. http://dx.doi.org/10.1515/med-2019-0093.

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AbstractBackgroundClinically relevant potential drug-drug interactions are considered preventable adverse drug reactions.ObjectiveThe aim of this study was to ascertain the frequency of potential drug-drug interactions in acute ischemic stroke patients and to explore factors associated with occurrence of potentially contraindicated drug-drug interactions.MethodsThis observational retrospective cohort and nested case-control study was carried out among patients treated for acute ischemic stroke at the Neurological Intensive Care Unit in the Clinical Centre Kragujevac, Serbia. The potentially dr
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