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Journal articles on the topic 'Drug Vitaton'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Svechkova, N., M. Sydorov, and A. Stadnyk. "Influence of biologically active additives on the fertility of channel catfish (Ictalurus punctatus)." Agroecological journal, no. 3 (September 30, 2016): 104–10. http://dx.doi.org/10.33730/2077-4893.3.2016.248875.

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One of the most important functions of humic substances is a stimulation and activation of physiological and biochemical processes in living organisms. Channel catfish (Ictalurus punctatus) — one of the main objects of commodity production in different countries, the value of the fish is a high rate of growth and the ability to adapt to growing conditions. This led to the selection the object of studies. As a result of studies we found dietary impact of feed additives humate, sodium humate potassium Vitaton drug on fertility and growth of different age groups of channel catfish (Ictalurus punc

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Nasution, Rahmadona Nasrun. "Sistem Analisis Prediksi Penjualan Vitamin di Apotek Menggunakan Metode Trend Moment." JURIKOM (Jurnal Riset Komputer) 9, no. 5 (2022): 1356. http://dx.doi.org/10.30865/jurikom.v9i5.4715.

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The coronavirus pandemic has also paralyzed the world economy, including Indonesia, in several sectors such as tourism and MSMEs. However, other sectors such as health and food remained stable and even experienced a surge in sales, especially sales of vitamin drugs at pharmacy outlets. One of them is Apotek Manjur Marendal, which experienced an increase in sales of medicines such as vitamins during the pandemic. To meet consumer demand and to process the right stock of vitamin drugs so that there is no loss, a prediction technique for vitamin drug sales is needed with data mining. With data mi

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Endang Susilowati and Dini Mei Arisa. "Prescribing Profile among Pregnancy in the Outpatient Pharmacy Installation of Bokor Hospital, Malang." Journal Pharmasci (Journal of Pharmacy and Science) 7, no. 2 (2022): 117–23. http://dx.doi.org/10.53342/pharmasci.v7i2.291.

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Drug therapy in pregnant women is important because it can cross the placental blood barrier so that it has a negative effect on fetal development. This study aims to determine the profile of drug prescription in pregnant women including drug therapy class, drug name, drug category based on fetal safety. This study aims to determine the profile of drug prescribing in pregnant women including drug therapy class, type of drug and drug category based on safety for the fetus. The study used retrospective data in the form of 100 prescription sheets at the Outpatient Pharmacy Installation of Bokor H

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4

Schümann. "Interactions Between Drugs and Vitamins at Advanced Age." International Journal for Vitamin and Nutrition Research 69, no. 3 (1999): 173–78. http://dx.doi.org/10.1024/0300-9831.69.3.173.

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Drug consumption increases at advanced age due to increased morbidity. At the same time the state of repletion is reduced for several vitamins. Physiological and kinetic alterations in the elderly are reviewed in order to analyse possible interrelations between these two phenomena. At high age the status of all vitamins is compromised by reduced food intake. Decreased active intestinal transport and an increased propensity for atrophic gastritis may reduce the absorption of vitamins A, B1, folate and B12. Decreased exposure to sunlight and reduced cutaneous synthesis impair the vitamin D statu

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Chen, Xuejie, Caihong Li, Da-Yun Jin, et al. "A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle." Blood 136, no. 7 (2020): 898–908. http://dx.doi.org/10.1182/blood.2019004234.

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Abstract Drug-induced bleeding disorders contribute to substantial morbidity and mortality. Antithrombotic agents that cause unintended bleeding of obvious cause are relatively easy to control. However, the mechanisms of most drug-induced bleeding disorders are poorly understood, which makes intervention more difficult. As most bleeding disorders are associated with the dysfunction of coagulation factors, we adapted our recently established cell-based assay to identify drugs that affect the biosynthesis of active vitamin K–dependent (VKD) coagulation factors with possible adverse off-target re

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Podszun, Maren, and Jan Frank. "Vitamin E–drug interactions: molecular basis and clinical relevance." Nutrition Research Reviews 27, no. 2 (2014): 215–31. http://dx.doi.org/10.1017/s0954422414000146.

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Vitamin E (α-, β-, γ- and δ-tocopherol and -tocotrienol) is an essential factor in the human diet and regularly taken as a dietary supplement by many people, who act under the assumption that it may be good for their health and can do no harm. With the publication of meta-analyses reporting increased mortality in persons taking vitamin E supplements, the safety of the micronutrient was questioned and interactions with prescription drugs were suggested as one potentially underlying mechanism. Here, we review the evidence in the scientific literature for adverse vitamin E–drug interactions and d

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Bhole, R. P., Yogita Shinde, C. G. Bonde, and R. D. Wavhale. "Vitamin Drug conjugate: a systematic review of pharmacological potential." Bulletin of the Karaganda University. "Chemistry" series 101, no. 1 (2021): 27–52. http://dx.doi.org/10.31489/2021ch1/27-52.

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Cancer is a chronic disease which can cause death. In traditional chemotherapycytotoxic drugs are used to kill proliferating cancer cells. The cytotoxic agent exhibits less specificity, less biological activity, causes sys-temic toxicity and undesirable side effects. Each year, about 1.8 million of the population are infected and die due to tuberculosis infection. An increase of drug resistance during the tuberculosis treatment is a significant concern. So, it is necessary to develop a new approach or therapies to resolve drug resistance, drug selectivity in tuberculosis infection and the redu

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Ko, Na Re, Sang Ju Lee, Arun Pandian Chandrasekaran, et al. "Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin." International Journal of Molecular Sciences 22, no. 20 (2021): 11298. http://dx.doi.org/10.3390/ijms222011298.

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Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here, we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising hydrophobic vitamin E and hydrophilic vitamin B labeled with dual pH and glutathione-responsive degradable linkages. Vitamin-based micelles (vitamicelles), formed by self-assembly in aqueous solutions, were optimized based on their stability after encapsulation of doxorubicin (DOX). The resulting vitamicelles have g

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International, Journal of Medical Science and Advanced Clinical Research (IJMACR). "Drug utilization study in department of obstetrics and gynecology at a tertiary care teaching hospital." International Journal of Medical Science and Advanced Clinical Research (IJMACR) 8, no. 2 (2025): 08–13. https://doi.org/10.5281/zenodo.15239753.

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<strong>Abstract</strong> <strong>Objective: </strong>To evaluate the trend of medication prescriptions in the department of obstetrics and gynaecology at a tertiary care teaching hospital. <strong>Methods</strong>: A prospective observational study on drug utilization patterns was done in the department of obstetrics and gynaecology at a tertiary care teaching hospital for 18 months. All inpatients and outpatients were included. After gaining informed consent, patients who met the inclusion criteria were enrolled. Medication orders were observed for prescription patterns. WHO Prescription ind

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Pinzon, R. T., M. Afifudin, and A. Digdoyo. "Severe Subconjunctival Bleeding in a Patient with Concomitant Use of Warfarin and Valproic Acid." Acta Medica Bulgarica 51, s1 (2024): 5–7. http://dx.doi.org/10.2478/amb-2024-0024.

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Abstract Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and affect warfarin metabolism, including valproic acid, which is capable of displacing warfarin from the protein binding site. Although this type of drug interaction is less widely recognized, it is a phenomenon that causes significant changes in the INR. We report a case of severe subconjunctival bleeding in patient with concomitant use of warfarin and valproic acid. The management include cessation of the drug, conservative eye

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11

Mukaddas, Alwiyah, Ingrid Faustine, and Putri Hijjah Ulti. "Profil Penggunaan Obat Antidotum Di Rumah Sakit Umum Daerah Undata Provinsi Sulawesi Tengah Periode 2016-2018." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) 5, no. 2 (2019): 132. http://dx.doi.org/10.22487/j24428744.0.v0.i0.13002.

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Antidotes drug is indicated in intoxication or poisoning patients, in addition to the antidote drugs, it can also be used as an appropriate therapeutic indication of his own medicine. The high increasing number of the antidote drug used every year in inpatient instalation Undata hospital, for exmple atropine, N-acetylcysteine and pyridoxine (vitamin B6). Therefore, this study aims to determine the percentage of drug use of antidote category indicated as an antidote therapy in Undata hospitals Central Sulawesi Province period 2016-2018. This is a descriptive study with retrospective approach an

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Mukaddas, Alwiyah, Ingrid Faustine, and Putri Hijjah Ulti. "Profil Penggunaan Obat Antidotum Di Rumah Sakit Umum Daerah Undata Provinsi Sulawesi Tengah Periode 2016-2018." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 5, no. 2 (2019): 132–39. http://dx.doi.org/10.22487/j24428744.2019.v5.i2.13002.

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Antidotes drug is indicated in intoxication or poisoning patients, in addition to the antidote drugs, it can also be used as an appropriate therapeutic indication of his own medicine. The high increasing number of the antidote drug used every year in inpatient instalation Undata hospital, for exmple atropine, N-acetylcysteine and pyridoxine (vitamin B6). Therefore, this study aims to determine the percentage of drug use of antidote category indicated as an antidote therapy in Undata hospitals Central Sulawesi Province period 2016-2018. This is a descriptive study with retrospective approach an

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Listratov, A. I., O. D. Ostroumova, M. V. Klepikova, and E. V. Aleshkovich. "Drug-induced hypocalcemia." Meditsinskiy sovet = Medical Council, no. 14 (October 18, 2021): 164–75. http://dx.doi.org/10.21518/2079-701x-2021-14-164-175.

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Hypocalcemia (HCa) is one of the main water-electrolyte disturbances in clinical practice. An acute decrease in serum calcium levels can lead to seizures, ventricular arrhythmias, bronchospasm and laryngospasm. Chronic HCa can result in disorientation and confusion. To prevent these complications, the risk factors for low calcium levels must be carefully evaluated. One of these factors is drugs, in which case we are talking about drug-induced (DI) HCa. The list of drugs-inducers of DI HCa is quite extensive, but the leading role in this disorder is played by drugs for the treatment of osteopor

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Bukhatwa, Salma Abdelkerim, Ali Ateia Elmabsout, Naseem Easim Jaber, et al. "Drugs Prescribing Trends in Three Polyclinics in Benghazi-Libya 2020." European Journal of Medical and Health Sciences 5, no. 2 (2023): 12–16. http://dx.doi.org/10.24018/ejmed.2023.5.2.1638.

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Background: There is an efforts made to improve drug prescribing practices in developing countries. The aim of present work was to comparing prescribing indicators, patient care, and missing information on prescriptions and identifying and assessing drug use patterns in three polyclinics in Benghazi city, Libya. Methods: In this descriptive cross section study a random sample of 1522 prescriptions were selected from three polyclinics include Ras-Ebida, Khalid Ibn-Elwalid and Al-Kish, over 4 months (July-October 2020). The data was collected through predesigned questionnaire. The prescriptions

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Sultana, Halima, Ayaka Kato, Ai Ohashi, et al. "Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line." Nutrients 13, no. 5 (2021): 1709. http://dx.doi.org/10.3390/nu13051709.

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The pregnane X receptor (PXR) is the key regulator of our defense mechanism against foreign substances such as drugs, dietary nutrients, or environmental pollutants. Because of increased health consciousness, the use of dietary supplements has gradually increased, and most of them can activate PXR. Therefore, an analysis of the interaction between drugs and nutrients is important because altered levels of drug-metabolizing enzymes or transporters can remarkably affect the efficiency of a co-administered drug. In the present study, we analyzed the effect of vitamin K-mediated PXR activation on

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del Ser, Teodoro, María-Ascensión Zea, Meritxell Valentí, et al. "Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people." Journal of Psychopharmacology 33, no. 8 (2019): 965–74. http://dx.doi.org/10.1177/0269881119857206.

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Background:Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors.Aim:To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.Methods:Medication intake was recorded during two years in 1087 individuals 70–85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years wa

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17

Bezboruah, Gayatri, and Shabnam Kalita. "Serum vitamin D status in children with epilepsy on antiepileptic drugs and its relation to the frequency of breakthrough seizures." International Journal of Contemporary Pediatrics 10, no. 8 (2023): 1262–67. http://dx.doi.org/10.18203/2349-3291.ijcp20232246.

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Background: Epilepsy is the most common neurological disorder in children requiring long term drug therapy which are associated with vitamin D deficiency. Antiepileptic actions of vitamin D deficiency have been extensively studied in animal models but human data, particularly in children is lacking. Objectives were to study the levels of serum vitamin D in children with epilepsy on antiepileptic drugs and to study the correlation between levels of vitamin D and frequency of breakthrough seizures. Methods: hospital-based cross-sectional study. Participants: A total of 94 children with epilepsy

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Forrester, Janet E., Katherine L. Tucker, and Sherwood L. Gorbach. "Dietary intake and body mass index in HIV-positive and HIV-negative drug abusers of Hispanic ethnicity." Public Health Nutrition 7, no. 7 (2004): 863–70. http://dx.doi.org/10.1079/phn2004617.

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AbstractObjective:Malnutrition in drug abusers has been attributed to poor diet. However, previous studies are conflicting. Many studies have not considered possible concurrent HIV disease. The purpose of this study was to determine the relationship between drug abuse and dietary intake in Hispanic Americans with and without HIV infection.Design:Dietary intake was measured using 3-day food records and 24-hour dietary recalls in three groups: HIV-positive drug abusers, HIV-negative drug abusers and HIV-positive persons who do not use drugs (‘non-drug abusers’).Setting:The baseline data from a p

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Kronenberger, Thales, Jasmin Lindner, Kamila A. Meissner, et al. "Vitamin B6-Dependent Enzymes in the Human Malaria ParasitePlasmodium falciparum: A Druggable Target?" BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/108516.

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Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6de novosynthesis present inPlasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes pres

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Focsa, Alin, Alexandru Sava, Andra Ababei, and Maria Apotrosoaei. "Drug interactions in gastrointestinal disorders therapy." Romanian Journal of Pharmaceutical Practice 14, S (2021): 25–29. http://dx.doi.org/10.37897/rjphp.2021.s.5.

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Drug-drug interactions are a major cause of adverse reactions in polypharmacy, the incidence being directly proportional to the number of associated drugs. In this work, we highlighted the main drug-drug interactions that occurred in the treatment of gastrointestinal symptoms with proton pump inhibitors and histamine H2-receptor antagonists. The two groups of agents, used in gastroesophageal reflux and ulcer disease, can be released and without a prescription on the recommendation of the pharmacist, contributing to the risk of emergence of drug-drug interactions. Drug-drug interactions can occ

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Lindtjørn, Bernt. "Essential Drug List in a Rural Hospital." Tropical Doctor 17, no. 4 (1987): 151–55. http://dx.doi.org/10.1177/004947558701700404.

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An essential drug list was introduced to Gidole Hospital (Gamu Gofa Region, southwestern Ethiopia) in 1980. This study considers whether the introduction of the essential drug list improved drug prescription. Drug usage by admitted patients was examined retrospectively by drawing samples from two one-year periods (1979 and 1983/84). This study demonstrates that a change in drug prescription occurred: a significant decrease of non-essential and placebo drugs as well as vitamin injection was achieved. Oral rehydration solution (ORS) became the main treatment for diarrhoeal diseases, while other

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Çoban Ramazan, Dilber, Ülker Anadol, A. Destina Yalçın, and A. Süha Yalçın. "Plasma homocysteine and aminothiol levels in idiopathic epilepsy patients receiving antiepileptic drugs." Turkish Journal of Biochemistry 44, no. 5 (2019): 661–66. http://dx.doi.org/10.1515/tjb-2018-0218.

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Abstract Objective Homocysteine is a sulfur containing amino acid that is formed during methionine metabolism. Patients under long-term antiepileptic drug treatment often have hyperhomocysteinemia. These patients have low levels of serum folate, vitamin B12 and vitamin B6, all of which are associated with homocysteine metabolism. We have investigated the effects of valproic acid and new generation antiepileptic drugs (lamotrigine and levetiracetam) on plasma levels of homocysteine and aminothiols as well as serum vitamin B12 and folic acid. Materials and methods Forty-seven idiopathic epilepti

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Maulidar, Rina, Nurjannah Nurjannah, Aulina Adamy, and Iskandar Iskandar. "Pengaruh pemberian obat anti tuberkulosis dengan vitamin D terhadap perubahan BTA pada penderita tuberkulosis paru di Kabupaten Pidie." Jurnal SAGO Gizi dan Kesehatan 2, no. 1 (2021): 25. http://dx.doi.org/10.30867/gikes.v2i1.442.

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Background: Tuberculosis (TB) is a global health problem, Indonesia had the second rank of the case in the world after India which is the fourth cause of death. Giving vitamin D together with anti-tuberculosis drugs can increase healing proses because vitamin D (anti-microbial immunomodulators) kills Mycobacterium tuberculosis.Objectives: This study aims to measure the effect of giving anti-tuberculosis drugs with vitamin D on changes in AFB in patients with pulmonary tuberculosis.Methods: This study was used a quasi-experiment design, pre-test and post-test control group was doing at 25th Mar

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V.V. Povoroznyuk, Н.S. Dubetska, and N.V. Zaverukha. "A modern perspective of antiepileptic drugs effect on Vitamin D rate (reference data and clinical case)." PAIN, JOINTS, SPINE 10, no. 4 (2020): 193–97. http://dx.doi.org/10.22141/2224-1507.10.4.2020.220460.

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This article presents a clinical case of the antiepileptic drug effect on the Vitamin D rate (namely, the patient has been taking Sodium Valproate for a long time) and new data from the foreign publications on this problem. It is known that there is a list of drugs that adversely affect the Vitamin D metabolism. In particular, the drugs reducing the Vitamin D absorption include drugs for the treatment of epilepsy. Antiepileptic drugs are drugs of various origins that are used to prevent or reduce seizures, their corresponding conditions (loss or impairment of consciousness, behavioral and aut

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Jayakumar, Ilathamizhan, and Jayanthi Mathaiyan. "A case of carbamazepine-induced vitamin B12 deficiency and neuropathy." International Journal of Basic & Clinical Pharmacology 8, no. 1 (2018): 166. http://dx.doi.org/10.18203/2319-2003.ijbcp20185178.

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Drug induced Neuropathy is seen commonly in patients undergoing treatment with drugs like phenytoin, dapsone, isoniazid etc. Carbamazepine is a drug used in the treatment in the treatment of focal seizure, generalized tonic - clonic seizure and trigeminal neuralgia. It is presented a case of carbamazepine induced vitamin B12 deficiency and neuropathy. A 21 year old male presented to our hospital with complaints of history of slipping of footwear while walking, numbness, impairment of balance and unsteadiness of gait in both lower limbs. Detailed history revealed the patient was on treatment wi

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Schindler, Rainer, Tanja Fielenbach, and Gerhard Rave. "Flupenthixol and cefotiam: effects on vitamin A metabolism in rats." British Journal of Nutrition 92, no. 4 (2004): 597–605. http://dx.doi.org/10.1079/bjn20041236.

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We examined the alterations in vitamin A metabolism as a result of flupenthixol or cefotiam administration. The impact of these drugs on indices of vitamin A status was evaluated in Brown Norway and Long–Evans rats. Intramuscular drug administration for 28 d resulted in a decline in systemic retinol. Changes in circulating retinol with time for chronic dosing showed drug treatment (P<0·001) and time (P<0·03) to be significant factors, but rat strain (P=0·33) was not a significant factor. Flupenthixol was the most active retinol-lowering compound (P<0·005). At the end of the 28 d perio

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Dalvi, Shubhangi M., Vinayak W. Patil, Nagsen N. Ramraje, Neelam Yeram, and Priti Meshram. "Study of vitamins in pulmonary Tuberculosis." International Journal of Research in Medical Sciences 7, no. 9 (2019): 3329. http://dx.doi.org/10.18203/2320-6012.ijrms20193909.

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Background: In recent years, progress in Tuberculosis (TB) control and eradication has been threatened by the emergence of drug resistant strains of Mycobacterium tuberculosis (MTB). Several studies describe micronutrient malnutrition in TB. This study focuses on the effect of drug resistance and disease progression on levels of various vitamins.Methods: The case control study comprised of 50 normal healthy human volunteers (Control), 50 newly diagnosed TB patients (CAT I) and 50 TB patients showing multi drug resistance (MDR). Recruited subjects were of both genders in age group of 18- 60 yea

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Zhang, Rui Xue, Ken Dong, Zhigao Wang, Ruimin Miao, Weijia Lu, and Xiao Yu Wu. "Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine." Pharmaceutics 13, no. 8 (2021): 1261. http://dx.doi.org/10.3390/pharmaceutics13081261.

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Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness, is critical to patients’ outcomes. However, many orally administered therapeutic drugs are susceptible to biotransformation by a group of important oxidative enzymes, known as cytochrome P450s (CYPs). In particular, CYP3A4 is a low specificity isoenzyme of the CYPs family, which contributes to the metabolism of approximately 50% of all marketed drugs. Induction or inhibition of CYP3A4 activity results in the varied oral bioavailability and unwanted drug-drug, drug-food, and drug-herb interactions.

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Kuncara, Rachmad Bayu, and Dewina Zumrotin Najiah. "Differences in Vitamin D3 Levels in Pulmonary Tuberculosis Patients Before and After One Month of Anti-Tuberculosis Drug Therapy." Jaringan Laboratorium Medis 6, no. 1 (2024): 18–25. http://dx.doi.org/10.31983/jlm.v6i1.11379.

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Pulmonary tuberculosis is an infectious disease caused by infection with the bacteria Mycobacterium tuberculosis. Patients diagnosed with pulmonary tuberculosis will receive Anti-Tuberculosis Drug (OAT) therapy for six months. In the first two months or what is called the intensive phase, the patient will be given a combination of OAT in the form of rifampicin, isoniazid, ethambutol and pyrazinamide. Several types of anti-tuberculosis drugs have the potential to affect vitamin D3 metabolism, either by interfering with absorption, metabolism or changing the action of vitamin D3. The long-term t

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Mooij, M., J. Windster, J. van Rosmalen, L. Hanff, D. Tibboel, and S. de Wildt. "P68 Significant oral drug use in critically ill children: rational therapy or a black box?" Archives of Disease in Childhood 104, no. 6 (2019): e45.2-e45. http://dx.doi.org/10.1136/archdischild-2019-esdppp.106.

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BackgroundThe disposition of orally prescribed drugs in critically ill children may be affected critical illness in in addition to age, resulting in erratic effects and safety. We aimed to study oral drug prescribing in the neonatal and pediatric intensive care unit (NICU and PICU).MethodsA one-year retrospective cohort study of all drug prescriptions, including route of administration for all children admitted to the NICU and PICU of the Erasmus MC-Sophia’s children’s hospital.Results1723 children with 2091 unique admissions received per admission (median [IQR]) 5 (3–10) drugs; 1 (0–2) orally

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Okonkwo, C. J., and E. C. Uwalaka. "The dynamics of anticoccidial drug usage in poultry within Umuahia, Abia state, Nigeria." Sokoto Journal of Veterinary Sciences 18, no. 4 (2021): 205–10. http://dx.doi.org/10.4314/sokjvs.v18i4.4.

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Coccidiosis is one of the most important parasitic diseases of poultry worldwide. Chemotherapy remains the principal means to control this disease albeit the increasing problems of drug resistance. The aim of this study was to examine the drug usage of anticoccidials in the six communities of Umuahia, Abia state. Data such as type, class and composition of drugs used, level and frequency of usage, route ofadministration and anticoccidial program adopted by different farms were collected from 85 poultry farms within the study region. Results showed that the ionophores anticoccidials were not in

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Vatutin, N. T., G. G. Taradin, G. A. Ignatenko, E. S. Gasendich, A. V. Harchenko, and I. B. Povaljaeva. "Decrease in Efficacy of Warfarin as a Result of Drug-Drug Interaction (Case Report)." Rational Pharmacotherapy in Cardiology 16, no. 1 (2020): 40–45. http://dx.doi.org/10.20996/1819-6446-2020-02-01.

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The one of the main aims in modern clinical pharmacology is to provide safe and effective therapy considering a frequent administration of several drugs having different drug-drug interactions. Warfarin belongs to the number of popular anticoagulants which along with its efficiency not infrequently alters anticoagulant characteristics when administered with other drugs and food products. A case of a decrease in the efficacy of warfarin in a patient with mitral stenosis while taking a combined choleretic drug is presented in the article. The components of this choleretic drug (dry animal bile,

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Siahaan, Ginta, Roy Ferdi Siallagan, Rumida Purba, and Riris Oppusungu. "MIKRONUTRIEN PENYEBAB ANEMIA PADA PENGGUNA NARKOBA DI MEDAN TEMBUNG." Media Gizi Indonesia 13, no. 2 (2018): 183. http://dx.doi.org/10.20473/mgi.v13i2.183-193.

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Drug users are generally vulnerable to malnutrition because of the side effects of drugs itself that has resulted in appetite reduction and nutrients malabsorption. Inadequate nutrient intake especially nutrient for haemoglobinsynthesis is the main cause of anemia among drug users. The aim of this research was to analyze the relationship between intake of micronutrients and haemoglobin level among drug users in Medan Tembung Sub District. Thisresearch was an observasional study with cross sectional design. The respondents was 73 drug users selected by snowball and accidental sampling technique

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Krejbich, Paula, and Marc Birringer. "The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review." Antioxidants 11, no. 11 (2022): 2149. http://dx.doi.org/10.3390/antiox11112149.

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Complementary and alternative medicine (CAM) supplements are widely used by cancer patients. Dietary supplements, vitamins and minerals, herbal remedies, and antioxidants are especially popular. In a systematic literature review, 37 studies, each including more than 1000 participants, on CAM, dietary supplement, and vitamin use among cancer patients were identified. Accordingly, cancer patients use antioxidants such as vitamin C (from 2.6% (United Kingdom) to 41.6% (United States)) and vitamin E (from 2.9% (China) to 48% (United States)). Dietary supplements and vitamins are taken for differen

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Luscher, T. F., and J. Steffel. "Vitamin K antagonists." Hämostaseologie 32, no. 04 (2012): 249–57. http://dx.doi.org/10.5482/ha-12050008.

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SummaryFor the last decades, anticoagulation for stroke prevention in atrial fibrillation (AF) as well as for the prophylaxis and long-term treatment of venous thromboembolism has been entirely based on vitamin K antagonists (VKA). Although very effective under optimal conditions, long-term treatment with these drugs is flawed by the fact that the time in the therapeutic range frequently is suboptimal due to biological factors, drug interactions and compliance.The direct thrombin inhibitor dabigatran, as well as the direct FXa inhibitors rivaroxaban and apixaban provide more consistent anticoa

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Suzuki, Seiya, Sungho Lee, Tatsuya Miyajima, et al. "Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles." Materials 14, no. 8 (2021): 1959. http://dx.doi.org/10.3390/ma14081959.

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Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be controlled. Hence, PLA/HAp core–shell particles are expected to be used as drug delivery carriers for hydrophobic drugs. In this work, PLA/HAp core–shell particles with a loading of vitamin K1 were prepared, and their drug-loading ability was evaluated. The partic

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Aamir, Muhammad, Asma Sadaf, Sehroon Khan, Shagufta Perveen, and Afsar Khan. "Recent Advancement in the Diagnosis and Treatment of Leprosy." Current Topics in Medicinal Chemistry 18, no. 18 (2018): 1550–58. http://dx.doi.org/10.2174/1568026618666181025100434.

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Background: Many of the tropical diseases are neglected by the researchers and medicinal companies due to lack of profit and other interests. The Drugs for Neglected Diseases initiative (DNDi) is established to overcome the problems associated with these neglected diseases. According to a report published by the WHO, leprosy (Hansen's disease) is also a neglected infectious disease. Methods: A negligible amount of advancements has been made in last few decades which includes the tools of diagnosis, causes, treatment, and genetic studies of the bacterium (Mycobacterium leprae) that causes lepro

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Adrover, Alessandra, Patrizia Paolicelli, Stefania Petralito, et al. "Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release." Pharmaceutics 11, no. 4 (2019): 187. http://dx.doi.org/10.3390/pharmaceutics11040187.

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In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG was cross-linked with calcium ions to prepare polymeric beads. Rheological studies and preliminary experiments of beads preparation allowed to identify the GG and the CaCl2 concentrations suitable for obtaining stable and spherical particles. GG beads were formed, through ionotropic gelation technique, with and without the presence of the synthetic clay laponite. The resultant beads were analyzed for dimensions (before an

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Cokro, Fonny, Laurentine Belinda Arfenda, and Hadiyanto. "Profile of online drug purchasing in marketplace by students at a Faculty of Medicine and Health Sciences in Jakarta, Indonesia." Pharmacy Education 23, no. 2 (2023): 144–48. http://dx.doi.org/10.46542/pe.2023.232.144148.

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Background: Digitalisation has increased the level of expenditure on online healthcare products. Various drug categories, ranging from over-the-counter to prescription-required drugs, are available online. Currently, no data on drug purchases in the Indonesian marketplace can be found. However, data from the Indonesian Internet Service Providers Association (APJII) in 2019 shows that 92.1% of students are internet users. Objective: The study aimed to investigate drug purchasing trends in Jakarta, with a particular focus on students enrolled in the Faculty of Medicine and Health Sciences. Metho

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Alam, Md Mahbubul, Faria Tasneem, AK Lutful Kabir, and Abu Shara Shamsur Rouf. "Study of Drug-Drug and Drug-Food Interactions of Mesalazine Through FTIR and DSC." Dhaka University Journal of Pharmaceutical Sciences 18, no. 2 (2019): 257–69. http://dx.doi.org/10.3329/dujps.v18i2.44466.

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A well-established drug used in the management of inflammatory bowel disease is 5-aminosalicylic acid (e.g. Mesalazine or Mesalamine). For the treatment of mild to moderate flares of ulcerative colitis and Crohn’s disease, Mesalazine has been used as the first line drug in both western and Asian countries due to its superiority over other drugs in terms of side effects and toxicities. Besides, some other drugs are also prescribed for total resolution of different symptoms of ulcerative colitis and associated diseases, which include Acetaminophen, Metronidazole and Vitamin D3. Moreover, physici

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Błasiak, J., and J. Kowalik. "Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate." Acta Biochimica Polonica 48, no. 1 (2001): 233–40. http://dx.doi.org/10.18388/abp.2001_5131.

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Genotoxicity of anticancer drugs is of a special interest due to the risk of inducing secondary malignancies. Vitamin C (ascorbic acid) is a recognized antioxidant and, since human diet can be easily supplemented with vitamin C, it seems reasonable to check whether it can protect against DNA-damaging effects of antitumor drugs. In the present work the ability of vitamin C to modulate cytotoxic and genotoxic effects of a cisplatin analog, conjugate (NH3)2Pt(SeO3), in terms of cell viability, DNA damage and repair in human lymphocytes was examined using the trypan blue exclusion test and the alk

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Zotova, Elena E., Elena I. Ryabinina, Алина F. Livanova, and Anastasia D. Salnikova. "COMPARATIVE CHARACTERISTICS OF PREPARATIONS BASED ON ROSEHIP FRUITS." Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny) 26, no. 2 (2023): 101–10. http://dx.doi.org/10.18499/2070-9277-2023-26-2-101-110.

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The paper presents a comparative analysis of preparations based on rosehip fruits available on the Russian market in order to determine the effectiveness and expediency of choosing a drug. It is shown that the expediency of choosing a drug should first of all be determined by the purpose of use, despite the fact that all drugs, in addition to specific action, exhibit similar biological activity due to the content of vitamin C and other biologically active substances (BAS), which, depending on the variety of rosehip and the method of preparation of drugs, are still in them in different quantiti

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Mogali, Sahana M., and Basavaraj C. Kotinatot. "Drug utilization study of antipsychotics among schizophrenia patients in a tertiary care teaching hospital: a retrospective observational study." International Journal of Basic & Clinical Pharmacology 9, no. 6 (2020): 971. http://dx.doi.org/10.18203/2319-2003.ijbcp20202185.

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Background: Aim of the study was to evaluate the drug utilization pattern of antipsychotics in schizophrenia patients in a tertiary care hospital.Methods: A retrospective observational study was conducted over a period of one year. Demographic data and drug utilization pattern of antipsychotics was collected from the surveyed prescriptions. Using WHO prescribing indicators data was analysed. Results were expressed in percentage.Results: Out of 300 prescriptions analysed, males were 58% and females 42%. Majority of schizophrenia patients were in age group of 15 to 45 years 70.33%. Olanzapine 75

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Nurhayati, Fitri, Dendhi Bagus Andriyanto, Fadhila Putri, and Rara Merinda Puspitasari. "Drug Use Patterns during the COVID-19 Pandemic: A Case Study at Persahabatan General Hospital." JURNAL ILMU KEFARMASIAN INDONESIA 21, no. 1 (2023): 115. http://dx.doi.org/10.35814/jifi.v21i1.1396.

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The COVID-19 pandemic condition has encouraged healthcare practitioners to adapt and constantly work to meet the needs of those who require healthcare, including medication supply. This study aims to provide the drug use patterns prior to and throughout the COVID-19 pandemic. This retrospective descriptive study analyzed the drug use patterns of 10 fast-moving drugs obtained through purposive sampling, as well as all medications listed in COVID-19 guideline therapy at Persahabatan general hospital. The drug use data was derived from the quarterly data from 2019 through the second quarter of 20

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Thongprasom, Kobkan, Tin Panyawaraphon, Thanapat Pathomkulmai, and Sahaphon Hungsaprug. "Razine folata i vitamina B12 kod Tajlanđana s oralnom lihenoidnom reakcijom povezanom s lijekovima." Acta Stomatologica Croatica 49, no. 3 (2015): 214–20. http://dx.doi.org/10.15644/asc49/3/3.

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Parasher, Ishan. "Vitamin D status among Pulmonary Tuberculosis Drug Induced Hepatotoxicity of Anti-tubercular Therapy." Journal of Medical Science And clinical Research 05, no. 05 (2017): 21984–90. http://dx.doi.org/10.18535/jmscr/v5i5.119.

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Rabbani, Hadiati, Fariz Nurwidya, Diyah Eka Andayani, Heidy Agustin, and Shaogi Syam. "Vitamin C Intake and Anti-Tuberculosis Drugs-Induced Hepatitis in Pulmonary Tuberculosis Patients." Jurnal Respirasi 10, no. 3 (2024): 214–21. http://dx.doi.org/10.20473/jr.v10-i.3.2024.214-221.

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Introduction: Drug-induced hepatitis (DIH) is one of the serious side effects of anti-tuberculosis drugs (ATD) that can reduce patient compliance with tuberculosis (TB) treatment, increase the risk of treatment failure, or develop drug resistance. Vitamin C is a potential antioxidant known to have a protective effect against DIH. This study examined the relationship between vitamin C intake and the incidence of ATD-induced hepatitis (ATDIH) in pulmonary TB patients at Persahabatan National Respiratory Referral Hospital, Jakarta. Methods: This was a cross-sectional study of 108 patients with dr

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Sulasmi, Sulasmi, Muchlisyam Muchlisyam, and Ginda Haro. "Simultaneous Analysis of Tablets Content Vitamin C And Zinc In Visible Spectrophotometry." International Journal of Science, Technology & Management 4, no. 2 (2023): 386–92. http://dx.doi.org/10.46729/ijstm.v4i2.782.

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Most drugs on the market contain multiple active ingredients, each of which is intended to enhance the drug's therapeutic effect and ease of administration. Determination of the levels of efficacious substances in drug preparations is essential for agencies that conduct drug determinations, such as the Food and Drug Supervisory Agency (BPOM) and the drug industry; therefore, a rapid and dependable analytical method, as well as relatively inexpensive and easily accessible tools and operational costs, are required. In practice, however, it can produce accurate and precise results. This research

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Muhammad Daniyal and Abdullah Ahmad. "A Possible Solution to Statin Noncompliance." Journal of the Pakistan Medical Association 74, no. 6 (2024): 1210. http://dx.doi.org/10.47391/jpma.9740.

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Dear Sir/Madam Pakistan is one of the top six countries for Cardiovascular deaths and it is estimated that 4.7 million people will die from Cardiovascular deaths between 2005-2027[1]. Considering the burden of cardiovascular disease, it is imperative that we focus our efforts on preventing and addressing risk factors while simultaneously ensuring that the goals of our preventive strategies are met. One such issue arises with statins. Statin drugs are the first line drug therapy for dyslipidemia (a significant risk factor for CVDs) and the most widely prescribed drugs for dyslipidemia treatment

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Levy, Sheldon L., W. M. Burnham, A. Bishai, and Paul A. Hwang. "The Anticonvulsant Effects of Vitamin E: A Further Evaluation." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 19, no. 2 (1992): 201–3. http://dx.doi.org/10.1017/s0317167100042268.

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ABSTRACT:Vitamin E (d-α-tocopherol) has proven to be a useful adjunct to anticonvulsant drugs in clinical studies. Improvement has occurred even in patients with complex partial seizures, which are often resistant to drug therapy. In animals, vitamin E is effective against ferrous chloride seizures, hyperbaric oxygen seizures and penicillin-induced seizures. It has failed, however, to show anticonvulsant effects in the standard animal models used for drug screening – the maximal electroshock and threshold pentylenetetrazol tests. The present experiments were designed to further explore the ant

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