Log in

Relevant bibliographies by topics / Drug / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Drug.

Dissertations / Theses on the topic 'Drug'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Drug.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Keesling, James Richard. "An evaluation of the drugs crime nexus, legalization of drugs, drug enforcement, and drug treatment rehabilitation." CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1697.

Full text

Abstract:

Law enforcement agencies are faced with the problem of how to reduce crime in the most economical method possible without violating the law. Since drug offenders also engage in a disproportionate amount of non-drug crime, then drug enforcement is considered as an acceptable general crime control method. Unfortuantely, this is an expensive option because incarcerating offenders is both costly and ony a short-term solution to the problem. A review of existing research examining the prior criminal histories of drug offenders compared to their previous involvement in violent and property crime is

APA, Harvard, Vancouver, ISO, and other styles

2

Apps, MIchael Garry. "Platinum anticancer drugs and drug delivery systems." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14409.

Full text

Abstract:

In this thesis two different ways to improve platinum-based chemotherapy were investigated. The first was through the use of a new slow release clay-based drug delivery vehicle and the second through the design and synthesis of novel dinuclear platinum complexes. For the clay-based drug delivery research, the platinum anticancer complex [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)] chloride, PHENSS, was loaded into montmorillonite (MMT) clay. The PHENSS was found to be incompletely burst released from the MMT. The MMT also had a negative effect on the in vitro cytotoxicity of P

APA, Harvard, Vancouver, ISO, and other styles

3

Yeh, Teng-Kuang. "Pharmacokinetics of anti-aids and anti-cancer drugs : implications on drug delivery and drug interaction /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu148654688938101.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Mannheimer, Buster. "Drug-related problems with special emphasis on drug-drug interactions." Stockholm : Department of Clinical Science and Education, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-602-6/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Carroll, Steven M. McGuire Marvin H. "The economics of the drug war : effective federal policy or missed opportunity? /." Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2002. http://library.nps.navy.mil/uhtbin/hyperion-image/02Jun%5FCarroll%5FMcGuire.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Osorio, Javier. "Hobbes on drugs| Understanding drug violence in Mexico." Thesis, University of Notre Dame, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3738644.

Full text

Abstract:

<p> This dissertation analyzes the unprecedented eruption of organized criminal violence in Mexico. To understand the dynamics of drug violence, this dissertation addresses three questions. What explains the onset of the war on drugs in Mexico? Once the conflict starts, why does drug violence escalate so rapidly? And lastly, why is there subnational variation in the concentration of violence? </p><p> Based on a game theoretic model, the central argument indicates that democratization erodes the peaceful configurations between the state and criminal organizations and motivates authorities to

APA, Harvard, Vancouver, ISO, and other styles

7

Raedisch, Steffen. "Drug transport and drug-drug interactions at the blood-brain barrier." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2005162/.

Full text

Abstract:

Membrane transporters are increasingly recognised as being important in determining drug pharmacokinetics at whole body, organ, and cellular levels. At the blood-‐brain barrier (BBB), membrane transporters determine the passage of drugs into and out of the brain. About 30 % of all patients are classed as non-‐responders for both epilepsy and schizophrenia. Drug transporters from the adenosine 5'-‐ triphosphate (ATP)-‐binding cassette (ABC) transporter family or from the solute carrier (SLC) superfamily may contribute to these drug resistant phenotypes but most have received limited attenti

APA, Harvard, Vancouver, ISO, and other styles

8

Sikri, Vineet Mitra Ashim K. "Efflux transporters mediated drug-drug interaction." Diss., UMK access, 2004.

Find full text

Abstract:

Thesis (M.S.)--School of Pharmacy. University of Missouri--Kansas City, 2004.<br>"A thesis in pharmaceutical sciences." Typescript. Advisor: Ashim K. Mitra. Vita. Title from "catalog record" of the print edition Description based on contents viewed Feb 28, 2006. Includes bibliographical references (leaves 94-107). Online version of the print edition.

APA, Harvard, Vancouver, ISO, and other styles

9

Hughes, Caitlin Elizabeth. "Overcoming obstacles to reform : making and shaping drug policy in contemporary Portugal and Australia /." Connect to thesis, 2006. http://eprints.unimelb.edu.au/archive/00003215.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

McGuffog, Ingrid Diana. "Drug Use and Drug Control Policy: Evaluating the Impact of Precursor Regulation on Drug User Behaviour." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/366750.

Full text

Abstract:

Controlling the availability of illicit drugs and their use is an exemplar of a wicked problem. Reducing the scale of the illicit drugs market through suppressing supply has proven extremely difficult. A recent systematic review of studies by Cunningham and colleagues who have produced a series of research papers examining the impact of precursor regulations on various methamphetamine outcomes in North America, argue this research represents the most compelling evidence to date that ‘precursor regulations, or indeed any supply control strategy, can have significant impacts on the retail market

APA, Harvard, Vancouver, ISO, and other styles

11

Fairbrother, Sally M. "Evading drug efflux with drug-binding peptides." Thesis, University of Manchester, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512210.

Full text

Abstract:

The efflux of drugs, particularly multi-drug resistant (MDR) drugs, by transporters such as P-glycoprotein provides an additional hurdle to achieving high levels of drug bioavailability. The aim of this project was to investigate drug-binding peptides as potential delivery tools, which might circumvent drug efflux by transporters such as Pglycoprotein. Popkov et 01 1998 reported a number of phage-displayed peptides (I Omers), which bound to doxorubicin. A literature search was carried out and several other potential drug-binding sequences were identified. Peptides were synthesised and then scr

APA, Harvard, Vancouver, ISO, and other styles

12

Pandie, Mishal. "Drug-drug interactions between antiretrovirals and bedaquiline." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27401.

Full text

Abstract:

Tuberculosis (TB) is a leading cause of morbidity and mortality worldwide. People living with HIV are particularly susceptible to TB infection, and treatment of HIV-TB co-infection is challenging for multiple reasons, including potential drug-interactions. Drug-resistant TB is difficult to treat and is associated with high treatment failure rates, mainly because the antimycobacterial drugs currently available are ineffective against drug-resistant TB. Bedaquiline is a new antimycobacterial drug which has shown great promise through its excellent efficacy for treating drug-resistant TB. Being a

APA, Harvard, Vancouver, ISO, and other styles

13

CHIARAPPA, GIANLUCA. "Drug nanocrystals in drug delivery and pharmacokinetics." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2917681.

Full text

Abstract:

As the oral route has always been the simplest and most appreciated way to administer drugs, the increasing number of new active drugs with very low solubility in water become a serious issue for the effectiveness of new medicinal specialties. Thus far, the best solution to this issue seems to be nanonization, i.e. the production of drugs as nanocrystals, which, by dramatically increasing crystal surface-volume ratio, reduces drug melting temperature with a relevant increase of drug solubility. Owing to experimental difficulties – presence of impurities, polymorphic forms, and Ostwald ripening

APA, Harvard, Vancouver, ISO, and other styles

14

Rosenbaum, Erik. "Optical characterization of potential drugs and drug delivery systems." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40177.

Full text

Abstract:

This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. These methods include optical absorption and fluorescence as well as time-resolved fluorescence. Upon covalently linking compounds with high quantum yields of fluorescence to specific parts of the pilicide, the biological impact was found to increase for some of the derivatives. Furthermore, by expanding the aromatic part of

APA, Harvard, Vancouver, ISO, and other styles

15

Attardo, Giorgio G. (Giorgio Giovanni). "Drug design and synthesis of novel heteroanthracycline antitumor drugs." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74641.

Full text

Abstract:

Novel heteroanthracycline antitumor drugs were designed based on structure activity relationship studies and known mechanisms of drug action. Their preparation required the development of a general synthetic approach.<br>After extensive studies, three methodologies were developed for the general synthetic plan. The first method involved photoenolisation of 2,5-dimethoxybenzaldehyde and SO$ sb2$ entrapment of the o-quinodimethane to give 4,7-dimethoxy-1-hydroxy-1,3-dihydrobenzo(2,3-c) thiophene-2,2-dioxide. This compound served as a general intermediate towards the synthesis of several heteroan

APA, Harvard, Vancouver, ISO, and other styles

16

Hill, John C. "DRUMMING AWAY DRUGS: AN INNOVATIVE ALTERNATIVE TOWARDS DRUG REHABILITATION." UKnowledge, 2014. http://uknowledge.uky.edu/cld_etds/14.

Full text

Abstract:

Drug use poses a serious threat to the quality of life for many Kentuckians and their families. Recent statistics indicate drug offenders account for a significant portion (in one year, 52,597 arrests were made for drug violations statewide) of individuals within thecriminal justice system, directly affecting the economic vitality within our state (Bunn & Slavova, 2012; Federal Bureau of Investigation, 2012). These statistics signify an overwhelming need for effective prevention efforts and innovative treatment alternatives. This study provides an innovative alternative treatment for drug offe

APA, Harvard, Vancouver, ISO, and other styles

17

Hemingway, Judith Frances Mary. "Spatializing drugs discourses : cultural geographies of illicit drug-using." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/10020432/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Foulkes, Broderick M. "Developing novel drug delivery methods for anti-leishmanial drugs." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/393974.

Full text

Abstract:

Background: Leishmaniasis is a DNDi listed disease caused by protozoan parasites of the kinetoplastida class. The disease currently spans over 80 countries, across the New World and Old World, potentially affecting 500 million people with 1 million new cases reported annually. Leishmaniasis is a vector-driven disease, utilizing two genus of sand fly, Phlebotomus sand fly is responsible for Old World transmission, whereas the Lutzomyia sand fly is responsible for New World transmission. The two main stages of leishmaniasis, are the diagnostic stage (promastigote in sand fly) and the infective s

APA, Harvard, Vancouver, ISO, and other styles

19

Pavuluri, Nina. "Development and evaluation of drug-admicelle systems for poorly soluble drugs : a novel surfactant templated drug delivery platform /." Full text available from ProQuest UM Digital Dissertations, 2008. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1781035201&SrchMode=1&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1258661510&clientId=22256.

Full text

Abstract:

Thesis (Ph.D.)--University of Mississippi, 2008.<br>Typescript. Vita. Major advisor: John O' Haver "June 2008." Includes bibliographical references (leaves 120-163). Also available online via ProQuest to authorized users.

APA, Harvard, Vancouver, ISO, and other styles

20

Wong, Ka Yeung Mark. "Drug clearance mechanisms and chemotherapy response." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28094.

Full text

Abstract:

Cytotoxic chemotherapeutic agents have a major role in the treatment of cancers. However, many cytotoxic agents have a narrow therapeutic window with best treatment response achieved only within a small range of drug concentrations.

APA, Harvard, Vancouver, ISO, and other styles

21

Chan, Kin-yi Ivy. "A study of determinants of relapse in psychotropic substance abuse /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19470757.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Claborn, Jordan, Moses Holleyman, and John B. Bossaer. "Consistency of Drug Information Resources in Identifying Drug-drug interactions with Oral Antineoplastic Agents." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2346.

Full text

Abstract:

Targeted oral antineoplastic agents (OAs) have become a staple and rapidly growing field in the realm of cancer treatment. As with any chemotherapeutic/narrow spectrum agent, clinicians have to be aware of potential drug interactions that could interfere with therapy. Drug information databases are a common resource utilized to check for interactions between agents and patient's home medications. A major concern with OAs is that they are usually taken at home as well as picked up at a pharmacy by the patient themselves. With this kind of therapy adherence and patient side effect reporting beco

APA, Harvard, Vancouver, ISO, and other styles

23

Clayborn, Jordan, Moses Holleyman, and John B. Bossaer. "Reliability of Drug Information Databases in Identifying Drug-drug Interactions with Oral Antineoplastic Agents." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2349.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Wang, Yan. "Peptide-drug conjugate for Her2-targeted drug delivery." Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3567.

Full text

Abstract:

Recent strategies for anticancer drug design have been focused on utilizing antibody as a drug or targeted moiety for targeted drug delivery. Antibody−drug conjugates (ADCs) have become a promising new class of targeted therapeutic agents for treatment of cancer. ADCs are designed to preferentially direct a cytotoxic drug to a cell-surface antigen recognized by an antibody. However, there are some challenges in developing ADCs, such as limited solid tumor penetration, high manufacturing costs and antibody-drug stoichiometry. Smaller molecules such as peptides have been shown to specifically bi

APA, Harvard, Vancouver, ISO, and other styles

25

Herzberg, Benjamin. "Fluorous Drug-Affinity Proteomics for Cancer Drug Discovery." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:15821582.

Full text

Abstract:

Identifying the intracellular targets of small molecules – target ID – is a major problem in chemical biology with broad application to the discovery and development of novel therapies. Traditional target ID studies have relied on drug-affinity chromatography to separate biological mixtures combined with mass spectrometry shotgun sequencing for peptide identification. This workflow is limited, however, by low specificity for unique peptides, high demand for cellular material, unknown depth of profiling, and other problems. To address these problems, we explore and describe here a novel strateg

APA, Harvard, Vancouver, ISO, and other styles

26

Hartmann, Neil Godfried. "Intercalative drugs in cancer chemotherapy : two approaches towards drug development." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292983.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Kaza, Lakshmi S. "Novel Thermal Analytical Techniques to Characterize Drugs and Drug Delivery." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1317258017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Kigen, Gabriel Kimutai. "Assessment of Drug Interactions Between Antiretroviral and the Anthelminthic drugs." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507508.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Vaidya, B. K. "Chiral separation of drugs and drug intermediates by immobilized biocatalyst." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2009. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2773.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Zhang, Huarui. "Design, synthesis and activity evaluation of novel exosome inhibitors." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/849.

Full text

Abstract:

Background: Exosomes are extracellular vesicles (EVs) that produced in the endosomal compartment of most eukaryotic cells, and have observed increasing attentions over the past decades. They play important roles in cell- to-cell communications, they can carry varieties of substances, like proteins, nucleic acids and lipids, to the target cells they encounter. These cargos could influence the function of recipient cells. This novel mode of intercellular communication is found to be of critical importance to many cellular activities. However, exosomes are involved in various diseases processes.

APA, Harvard, Vancouver, ISO, and other styles

31

Nissen, Lisa Monique. "Quality use of medicines : from drug use evaluation to rural community pharmacy practice /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16549.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Tayob, Shamima. "Challenges in the management of drug supply in public health centres in the Sedibeng District, Gauteng Province." Thesis, University of Limpopo (Medunsa Campus), 2012. http://hdl.handle.net/10386/683.

Full text

Abstract:

Thesis (MSc(Med)(Pharmacy))--University of Limpopo, 2012.<br>ABSTRACT South Africa, 80% of the population is dependent on the vernment to provide for their health care needs, mainly ugh primary health care facilities. In the health objectives of the National Drug Policy, the government of South Africa outlines its commitment to ensuring availability and accessibility of medicines which are effective, affordable, safe and of good quality in all sectors of the health care system ( N a t io

APA, Harvard, Vancouver, ISO, and other styles

33

Kwan, Ming-tak Kalwan, and 關明德. "Drug careers: an interactional pathway into adolescent drug-use." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29757678.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Suhardi, Vincentius Jeremy. "Drug eluting prosthetic joints through drug cluster morphology control." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111323.

Full text

Abstract:

Thesis: Ph. D. in Medical Engineering and Medical Physics, Harvard-MIT Program in Health Sciences and Technology, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 299-330).<br>More than one million joint replacements are performed in the USA annually. However, around 10 % of patients require revision surgery within 10 years with prosthetic joint infections (PJI) as a common reason. PJI has a recurrence rate of 16 %, a mortality rate of 2.5 %, and end-stage treatments involving arthrodesis and amputation. Most drug eluting polymers that were in develo

APA, Harvard, Vancouver, ISO, and other styles

35

Clark, Justin. "An evaluation of Warfarin and Statin Drug-Drug Interactions." The University of Arizona, 2012. http://hdl.handle.net/10150/623593.

Full text

Abstract:

Class of 2012 Abstract<br>Objectives: To evaluate the literature with respect to drug-drug interactions of the hydroxymethylglutaryl CoA reductase inhibitors atorvastatin, fluvastatin, lovastatin, pitavastitin, pravastatin, simvastatin, and rosuvastatin with warfarin. Methods: This descriptive retrospective study identified articles reporting on each drug-drug interaction from the online databases PubMed (1970 – February 2012) and the drug compendia Micromedex and Facts & Comparisons. The studies included in this investigation were primary literature reports, written in English with human sub

APA, Harvard, Vancouver, ISO, and other styles

36

Clark, Justin, and Daniel Malone. "An Evaluation of Warfarin and Statin Drug-Drug Interactions." The University of Arizona, 2012. http://hdl.handle.net/10150/614476.

Full text

Abstract:

Class of 2012 Abstract<br>Objectives: To evaluate the literature with respect to drug-drug interactions of the hydroxymethylglutaryl CoA reductase inhibitors atorvastatin, fluvastatin, lovastatin, pitavastitin, pravastatin, simvastatin, and rosuvastatin with warfarin. Methods: This descriptive retrospective study identified articles reporting on each drug-drug interaction from the online databases PubMed (1970 – February 2012) and the drug compendia Micromedex and Facts & Comparisons. The studies included in this investigation were primary literature reports, written in English with human

APA, Harvard, Vancouver, ISO, and other styles

37

Larson, Joeanna Lee. "Perinatal Drug Abuse Intervention: Policy Development for Drug Screening." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2555.

Full text

Abstract:

Perinatal drug abuse is becoming a profound issue facing the health and wellbeing of neonates. The community serviced by the project site, which lies within the boundaries of an Indian Reservation, suffers from perinatal drug abuse at a higher rate than state and federal averages. The purpose of this project was to provide the project site with a policy to consistently screen for perinatal drug abuse. Lave's theory of situational learning and the Sanford Way model for quality improvement framed this project. To guide policy development, data were compiled through a systematic review of current

APA, Harvard, Vancouver, ISO, and other styles

38

Wheeler, Daniel Wren. "Weakened by strengths : drugs in solution, medication error and drug safety." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:238087a5-120b-4a3d-9437-5840cecf8b6a.

Full text

Abstract:

The concentrations of some drug solutions are often expressed as ratios or percentages. This system simplified prescription and dispensing when Imperial measures such as grains and minims were used. Ampoules of powerful vasoactive drugs such as catecholamines and potentially toxic local anaesthetics are still labelled as ratios and percentages, seemingly through habit or tradition than for any useful clinical reason. This thesis argues that adherence to this outdated system is confusing, causes drug administration errors, and puts patients at risk. Internet-based questionnaires were used to qu

APA, Harvard, Vancouver, ISO, and other styles

39

Parker, S. M., and John B. Bossaer. "Comparison of Drug Information Resources in Identifying Drug-drug Interactions in Newly Approved Oral Antienplastic Agents." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/2343.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Michaelsen, Maria Høtoft. "The effect of digestion and drug load on absorption of poorly water soluble drugs from self-nanoemulsifying drug delivery systems (SNEDDS)." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59178.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Patel, Fadheela. "Development of a cost-effective drug sensitivity test for multi-drug resistant and extensively drug-resistant tuberculosis." Thesis, Cape Peninsula University of Technology, 2010. http://hdl.handle.net/20.500.11838/1496.

Full text

Abstract:

Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2010<br>The World Health Organisation estimates that nine million people are infected with tuberculosis (TB) every year of which ninety-five percent live in developing countries. Africa has one of the highest incidences of TB in the world. but few of its countries are equipped to diagnose drug-resistant TB. This study aimed to develop a robust. yet simple and cost-effective assay. which would require minimal sophisticated instrumentation and specialised personnel that would make drug sensitivity screening for

APA, Harvard, Vancouver, ISO, and other styles

42

Pan, Xiaolei. "THE SLC22 TRANSPORTER FAMILY: NOVEL INSIGHTS TO ROLES IN DRUG EFFICACY, DRUG-DRUG INTERACTIONS AND MOOD DISORDERS." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3983.

Full text

Abstract:

Numerous studies have demonstrated the impact of organic cation (OCTs; SLC22 family) and anion transporters (OATs; SLC22 family) on the efficacy and safety of clinically important therapeutics. To be specific, OCTs and OATs have been identified as determinants for uptake into and secretion from enterocytes, hepatocytes and renal proximal tubular cells, and are frequent sites of drug-drug interaction (DDI). In addition, OCTs expressed in brain are components of the low-affinity, high capacity clearance pathway (uptake-2) for biogenic monoamine neurotransmitters. As a result, OCTs may represent

APA, Harvard, Vancouver, ISO, and other styles

43

Unell, Ira. "Problem drug users and drug workers : their beliefs in the origins and treatment of problem drug use." Thesis, Loughborough University, 1997. https://dspace.lboro.ac.uk/2134/6843.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Lickteig, Andrew Joseph. "Drug Metabolizing Enzyme, Drug Transporter Expression And Drug Disposition Are Altered In Models Of Inflammatory Liver Disease." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/193836.

Full text

Abstract:

Correct dosing in pharmacotherapeutics is based on the idea that too much of a drug will cause toxicity, while too little will result in failure to elicit the desired response. A major factor in the ability of a patient to handle any dose of a drug is the capacity to metabolize and eliminate that drug from the body. For the vast majority of drugs, the liver plays a key role in determining the rate at which drugs are eliminated. First, drugs must be taken up across the cell membrane into hepatocytes by uptake transporters. Once inside the hepatocyte, biotransformation enzymes metabolize and con

APA, Harvard, Vancouver, ISO, and other styles

45

Mahaguna, Vorapann. "Investigation of cellulose ether polymers in controlled drug delivery." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037524.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Tooley, Jennifer. "Demon drugs and holy wars, Canadian drug policy as symbolic action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ54654.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Banks, Simon. "Incompatibilities between HPMC and model drugs : consequences for extended drug release." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421473.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Javaheri, Hoda. "Wet granulated liquisolid drug delivery systems with hydrophobic and hydrophilic drugs." Thesis, University of Sunderland, 2017. http://sure.sunderland.ac.uk/8549/.

Full text

Abstract:

The formulation of hydrophobic drugs into appropriate dosage forms is challenging due to the problems associated with those drugs such as low solubility and poor dissolution. Using a liquisolid system is a promising method to improve the dissolution of hydrophobic drugs and in sustaining the release of hydrophilic drugs, in which solid drugs are dispersed in non-volatile liquid vehicles. The aim of this research was to use the liquisolid technique to enhance the dissolution rate of glibenclamide, a model hydrophobic drug, and to sustain the release of metformin-HCl, as a model hydrophilic drug

APA, Harvard, Vancouver, ISO, and other styles

49

Wang, Shining. "DRUG DEVELOPMENT OF TARGETED ANTICANCER DRUGS BASED ON PK/PD INVESTIGATIONS." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/2535.

Full text

Abstract:

Pharmaceutics<br>Ph.D.<br>EGFR inhibitors, such as gefitinib, are examples of targeted anticancer drugs whose drug sensitivity is related to gene mutations that adds a pharmacogenetic [PG] dimension to any pharmacokinetic [PK] and pharmacodynamic [PD] analysis. The goal of this project was to characterize the PK/PD properties of gefitinib in tumors and then apply these results to design rational drug design regimens, and provide a foundation for future studies with EGFR inhibitors. Progressions of in vitro and in vivo studies were completed to understand the PK and PD behavior of gefitinib. In

APA, Harvard, Vancouver, ISO, and other styles

50

MIELE, DALILA. "NANOPARTICLES AND NANOFIBERS AS DRUG DELIVERY SYSTEMS OF POORLY SOLUBLE DRUGS." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1321848.

Full text

Abstract:

La via sistemica rappresenta la scelta più comune per la somministrazione di attivi e per lottenimento delleffetto terapeutico. Ad essa sono associate una serie di limitazioni tra cui la distribuzione aspecifica del farmaco responsabile della scarsa efficacia terapeutica e degli effetti collaterali che si tramutano in effetti tossici su siti differenti dal bersaglio terapeutico. Per questo motivo, vie di somministrazione a rilascio locale hanno di recente attratto la ricerca scientifica nel formulare sistemi in grado di veicolare lagente terapeutico su cellule o tessuti specifici; tale operazi

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!