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Relevant bibliographies by topics / Drugs Chiral drugs

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Academic literature on the topic 'Drugs Chiral drugs'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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Journal articles on the topic "Drugs Chiral drugs"

1

STINSON, STEPHEN C. "CHIRAL DRUGS." Chemical & Engineering News 70, no. 39 (September 28, 1992): 46–79. http://dx.doi.org/10.1021/cen-v070n039.p046.

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STINSON, STEPHEN C. "CHIRAL DRUGS." Chemical & Engineering News 78, no. 43 (October 23, 2000): 55–78. http://dx.doi.org/10.1021/cen-v078n043.p055.

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STINSON, STEPHEN C. "CHIRAL DRUGS." Chemical & Engineering News 71, no. 39 (September 27, 1993): 38–65. http://dx.doi.org/10.1021/cen-v071n039.p038.

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STINSON, STEPHEN C. "Chiral Drugs." Chemical & Engineering News 72, no. 38 (September 19, 1994): 38–50. http://dx.doi.org/10.1021/cen-v072n038.p038.

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STINSON, STEPHEN C. "CHIRAL DRUGS." Chemical & Engineering News 73, no. 41 (October 9, 1995): 44–546274. http://dx.doi.org/10.1021/cen-v073n041.p044.

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Caner, Hava, and Israel Agranat. "Chiral Drugs." Enantiomer 7, no. 6 (November 1, 2002): 405–6. http://dx.doi.org/10.1080/10242430215704.

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Aboul-Enein, Hassan Y. "Chiral drugs." Chirality 15, no. 8 (2003): 730. http://dx.doi.org/10.1002/chir.10286.

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Brossi, Arnold. "Chiral drugs: Synopsis." Medicinal Research Reviews 14, no. 6 (November 1994): 665–91. http://dx.doi.org/10.1002/med.2610140604.

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Ranade, Vasant V., and John C. Somberg. "Chiral Cardiovascular Drugs." American Journal of Therapeutics 12, no. 5 (September 2005): 439–59. http://dx.doi.org/10.1097/01.mjt.0000167429.37357.0c.

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Mehvar, Reza, and Fakhreddin Jamali. "Bioequivalence of Chiral Drugs." Clinical Pharmacokinetics 33, no. 2 (August 1997): 122–41. http://dx.doi.org/10.2165/00003088-199733020-00004.

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Dissertations / Theses on the topic "Drugs Chiral drugs"

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Mifsud, Janet. "Chiral aspects of the disposition and pharmacology of the enantiometers of ethosuximide." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336672.

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Mashile, Tumelo Rameleko. "Enantioanalysis of pharmaceutical compounds." Pretoria : [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-02222007-195248.

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Layton, Sherry E. "Comparison of various chiral stationary phases for the chromatographic separation of chiral pharmaceuticals /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/laytons/sherrylayton.pdf.

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Kingston, Gillian A. "Chiral chromatography of enantiomeric cardiovascular and other drugs." Thesis, University of Surrey, 1990. http://epubs.surrey.ac.uk/844123/.

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Since the enantiomers of a number of racemic drugs have been found to have different activities or modes of action, enantioselective analysis is becoming more important. A number of different approaches to chromatographic chiral resolutions have been evaluated for their ability to resolve the enantiomers of racemic beta blocking drugs, Three chiral HPLC columns were investigated; a cyclodextrin phase, an (R)-3,5-dinitrabezoylphenylglycine phase and a protein phase. The acid glycoprotein phase successfully resolved atenolol, alprenolol, metoprolol, oxprenolol, propranolol and verapamil with 0.01M phosphate buffer eluents modified with either acetonitrile or isopropanol. The (R)-3,5-dinitrobenzoylphenylglycine phase was used with eluents of Isopropanol in hexane and resolutions of propranolol, oxprenolol, metoprolol, alprenolol and pronethalol were achieved after formation of the 1- or 2-naphthamide derivatives, although no separations were achieved for the underivatised samples. The cyclodextrin phase was also found to be unsuccessful in resolving underivatised samples of propranolol and verapamil. However preliminary results indicate that resolutions are possible after the formation of their trifluoroacetyl derivatives. The cyclodextrin phase was also successfully used to resolve the enantiomers of chlorpheniramine and the geometric isomers of clomiphene. In addition to the chiral HPLC stationary phases, a (+)-10-camphorsulphonic acid mobile phase additive was investigated, although this was found to be completely unsuccessful. Finally the use of a chiral diamide GLC column was investigated. This was not suited to the analysis of beta blockers, even after derivatisation, although derivatised amino acids were well resolved. The use of computer modelling to predict the degree of separation of enantlomers was also investigated for the (R)-3,5-dinitrabenzoyl phenylglycine phase, with the interaction energies between the phase and both isomers of each compound calculated for the most stable conformation. From a comparison with the experimental results, it was shown that this approach to prediction was unsuccessful.

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Watt, Alan Paul. "Liquid chromatographic and mass spectrometric methods for the chiral analysis of drugs and drug metabolites." Thesis, University of Hertfordshire, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421286.

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Karlsson, Louise. "P-glycoprotein and chiral antidepressant drugs : Pharmacokinetic, pharmacogenetic and toxicological aspects." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76126.

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The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. Transport across the cells is necessary for a drug to ensure that the drug reaches the site of action and transport proteins such as P-glycoprotein (P-gp; ABCB1) can limit the entrance into various tissues, including the brain. Molecules that are not superimposable on their mirror images and thus exist in two enantiomeric forms (enantiomers) are said to be chiral. A racemic compound is one composed of a 50:50 mixture of two enantiomers, S- and R-enantiomers. Two examples of frequently prescribed racemic drugs are the chiral antidepressants venlafaxine (VEN) and citalopram (CIT). The enantiomers of VEN possess different pharmacodynamic profiles where the R-enantiomer is a potent inhibitor of both serotonin and noradrenaline reuptake (SNRI), while the S-enantiomer is more selective in inhibiting serotonin reuptake (SSRI). The SSRI effect of CIT resides in the S-enantiomer, whereas the R-enantiomer is considered to be therapeutically inactive, or even that it counteracts the effects. The S-enantiomer of CIT is now available as a separate SSRI (escitalopram, EsCIT). VEN and CIT are also among the most commonly found drugs in forensic autopsy cases. Few previous studies have examined a possible enantioselective activity of P-gp. Thus, the general aim of this thesis was to study the enantiomeric distribution of chiral antidepressant drugs, focusing on the role of P-gp in the BBB. For this purpose, a mouse model disrupted of the genes coding for P-gp (abcb1ab (-/-) mice) was used. Brain and serum concentrations of the enantiomers of VEN and CIT, and their major metabolites, were compared to the corresponding wild-type mice (abcb1ab (+/+) mice). The open-field locomotor and rearing activities were examined after chronic VEN administration. In addition to the animal studies, genetic and toxicological aspects of P-gp were studied in a forensic autopsy material, where intoxication cases were compared with cases that were not related to intoxications. The brain to serum concentration ratios for VEN, CIT and EsCIT differed between knockout mice and wild-type mice, with 2-3 fold higher brain concentrations in mice with no expression of P-gp. Hence, all studied drugs, and their major metabolites, were substrates for P-gp. There was no evidence for a stereoselective P-gp mediated transport. The P-gp substrate properties were reflected in the open-field behavior test where the knockout mice displayed increased center activity compared with wild-type mice following chronic VEN exposure. The genotype distribution of ABCB1 SNPs C1236T, G2677T and C3435T in VEN positive cases was significantly (or borderline) different between the intoxication cases and the non-intoxication cases. This difference in genotype distribution was not observed for the CIT positive cases. To conclude, the present work has led to an increased knowledge about how the enantiomers of VEN and CIT are affected by the BBB transporter P-gp. Using an animal model, VEN and CIT have proved to be actively transported out of the brain by P-gp and no difference was observed for the enantiomers with regard to P-gp transport. Further, the ABCB1 genotype distribution was different in intoxication cases compared with non-intoxication cases. Taken together, these findings offer the possibility that the expression of P-gp in humans may be a contributing factor for limited treatment response and increased risk of side-effects following antidepressant drug treatment.

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Crabb, Nicholas Clive. "Applications of chiral chromatography to the analysis of drugs and herbicides." Thesis, University of Bradford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277117.

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Modzabi, Selorm Kwame Busch Kenneth W. Busch Marianna A. "Studies on new approaches of chiral discrimination for chiral analysis by regression modeling of spectral data." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5349.

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Rimmer, Duncan Adam. "Novel asymmetric microenvironments for separation of enantiomers chiral drugs and natural products." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254965.

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Eriksson, Tommy. "Pharmacokinetics of the enantionmers of thalidomide." Malmö : Lund : Malmö University Hospital ; Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945032.html.

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Books on the topic "Drugs Chiral drugs"

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Lin, Guo-Qiang, Qi-Dong You, and Jie-Fei Cheng, eds. Chiral Drugs. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.

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Sunjic, Vitomir, and Michael J. Parnham. Signposts to Chiral Drugs. Basel: Springer Basel, 2011. http://dx.doi.org/10.1007/978-3-0348-0125-6.

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Chirality and the biological activity of drugs. Boca Raton: CRC Press, 1995.

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Lin, Guo-Qiang. Chiral drugs: Chemistry and biological action. Hoboken, N.J: Wiley, 2011.

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Ahuja, Satinder. Chiral separation methods for pharmaceutical and biotechnological products. Hoboken, N.J: Wiley, 2010.

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Sunjic, Vitomir. Signposts to Chiral Drugs: Organic Synthesis in Action. Basel: Springer Basel AG, 2011.

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Eeckhaut, Ann van. Chiral separations by capillary electrophoresis. Boca Raton: Taylor & Francis, 2009.

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Misch, Kelly, and William D. Martineau. Chiral chemicals. Cleveland: Freedonia Group, 2001.

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Misch, Kelly, and William D. Martineau. Chiral chemicals. Cleveland: Freedonia Group, 1999.

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Ahuja, Satinder. Chiral separation methods for pharmaceutical and biotechnological products. Hoboken, N.J: Wiley, 2010.

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Book chapters on the topic "Drugs Chiral drugs"

1

Sun, Jiangqin, Dingguo Liu, and Zhimin Wang. "Representative Chiral Drugs." In Chiral Drugs, 401–48. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch11.

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Yang, Guang, and Hai-Zhi Bu. "Toxicology of Chiral Drugs." In Chiral Drugs, 381–99. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch10.

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You, Qi-Dong. "Resolution of Chiral Drugs." In Chiral Drugs, 137–94. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch4.

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Qiu, Xiao-Long, Xuyi Yue, and Feng-Ling Qing. "Fluorine-Containing Chiral Drugs." In Chiral Drugs, 195–251. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch5.

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Liu, Yongge, and Xiao-Hui Gu. "Pharmacology of Chiral Drugs." In Chiral Drugs, 323–45. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch8.

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Dong, Hanqing, Xiaochuan Guo, and Zengbiao Li. "Pharmacokinetics of Chiral Drugs." In Chiral Drugs, 347–79. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch9.

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Lin, Guo-Qiang, and Xing-Wen Sun. "Chiral Drugs through Asymmetric Synthesis." In Chiral Drugs, 29–76. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch2.

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Wang, Jianqiang, and Wenya Lu. "Chiral Drugs via Biocatalytical Approaches." In Chiral Drugs, 77–136. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch3.

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Liu, Rui, Carl Behrens, and Chao-Ying Ni. "Industrial Application of Chiral Technologies." In Chiral Drugs, 253–96. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch6.

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Lin, Guo-Qiang, Jian-Ge Zhang, and Jie-Fei Cheng. "Overview of Chirality and Chiral Drugs." In Chiral Drugs, 3–28. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118075647.ch1.

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Conference papers on the topic "Drugs Chiral drugs"

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Liu, Chunye, Yanqing Miao, Yihui Guo, Yinjuan An, Yunfang Li, Huanhuan Liu, Jia Chen, Jiarui Liu, and Huibin Dai. "Chiral drugs separation by a new antibiotics-based chiral stationary phase." In International Conference on Medical Engineering and Bioinformatics. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/meb140641.

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Du, Yong, Jianjun Liu, and Zhi Hong. "Characteristics of chiral and racemic ketoprofen drugs using terahertz time-domain spectroscopy." In ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, edited by Marco Rahm, Konstantin Vodopyanov, Wei Shi, and Cunlin Zhang. SPIE, 2013. http://dx.doi.org/10.1117/12.2033147.

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Bhushan, Indu. "Efficient media for high production of microbial lipase from Bacillus subtilis (BSK-L) using response surface methodology for enantiopure synthesis of drug molecules." In 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.044.

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Lipases are a multipurpose enzyme that holds a significant position in industrial applications due to its ability to catalyse a large number of reactions such as hydrolysis, esterification, interesterification, transesterification which makes it a potential candidate. It is also used for the separation of chiral drugs from the racemic mixture and this property of lipase is considered very important in pharmaceutical industries for the synthesis of enantiopure bioactive molecules. Assuming the tremendous importance of lipases, as stereoselective biocatalysts, in pharmaceuticals and various other commercial applications, industrial enzymologists have been forced to search for those microorganisms which are able to produce novel biocatalysts at reasonably high yield. In the present study microbial lipase was isolated from the water sample of pond at Katra, Jammu and Kashmir (India). This enzyme has shown wide specificity and higher enantioselectivity, which make it pharmaceutical important enzyme. To make it economical for industrial application, it was produced on cheap nutrient media using Response Surface Methodology and got maximum production. It was used for resolution of chiral drugs and the significant results obtained during the course of work shall have potential towards pharmaceutical industries.

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Zhang, Pengfei, Kalpesh Mehta, and Nanguang Chen. "High Sensitivity in Detecting Chiral Nanoparticles Using Optical Coherence Tomography." In Optical Molecular Probes, Imaging and Drug Delivery. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/omp.2013.mth2c.5.

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Miao Yu and Caixia Zhang. "Research on Centralist Tender for Drugs Purchase in China." In Industrial Engineering (CIE39). IEEE, 2009. http://dx.doi.org/10.1109/iccie.2009.5223902.

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Chen, SL, SX Kong, CD Bao, P. Mavros, S. Chen, and J. Pei. "OP0134 Nonsteroidal antiinflammatory drugs and hospitalizations for gastrointestinal complications in china." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.859.

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Vilaplana Prieto, Cristina. "Teaching experience: Inequalities in prices of drugs to fight against COVID-19." In Seventh International Conference on Higher Education Advances. Valencia: Universitat Politècnica de València, 2021. http://dx.doi.org/10.4995/head21.2021.12549.

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As the Sars-CoV2 pandemic continues to grow, researchers around the world are urgently seeking new treatments to prevent infection, cure those infected, or lessen the severity of the disease. Although there are several recently approved vaccines, clinical trials are underway to "re-use" drugs normally indicated for other diseases. This teaching experience studies the market for 8 pharmaceutical products used to fight the pandemic (remdesivir, favipiravir, lopinavir/ritonavir, chloroquine, hydroxychloroquine, sofosbuvir, pyrfenidone and tocilizumab) in 13 countries (Bangladesh, Brazil, China, Egypt, France, India, Malaysia, Pakistan, South Africa, Sweden, Turkey, United Kingdom and United States). Through the analysis of prices and costs, we reflect on the difficulty of access to treatment according to the country.The objective is to deepen knowledge of the pharmaceutical market: (i) to demonstrate in a tangible way the differences between production costs and final prices of medicines, (ii) to perceive the difficulty of access to certain treatments depending on the country, (iii) to reflect on what initiatives should be implemented in an international emergency context such as the one we are experiencing.

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Petrov, Georgi I., and Vladislav V. Yakovlev. "Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules." In SPIE BiOS, edited by Kin Foong Chan and Conor L. Evans. SPIE, 2017. http://dx.doi.org/10.1117/12.2252944.

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Biswas, Aritra, Abraham Vázquez-Guardado, and Debashis Chanda. "Superchiral light generation on nanoimprinted achiral plasmonic substrates for chiral drug detection." In Advanced Fabrication Technologies for Micro/Nano Optics and Photonics XIV, edited by Georg von Freymann, Eva Blasco, and Debashis Chanda. SPIE, 2021. http://dx.doi.org/10.1117/12.2584087.

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Matas, David. "Anti-rejection Drug Trials and Sales in China." In Annual International Conference on Law, Regulations and Public Policy. Global Science & Technology Forum (GSTF), 2012. http://dx.doi.org/10.5176/2251-3809_lrpp1230.

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Reports on the topic "Drugs Chiral drugs"

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Tanner, Murray S. China Confronts Afghan Drugs: Law Enforcement Views of The Golden Crescent. Fort Belvoir, VA: Defense Technical Information Center, March 2011. http://dx.doi.org/10.21236/ada540536.

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Tanner, Murray S. Trafficking Golden Crescent Drugs into Western China: An Analysis and Translation of a Recent Chinese Police Research Article. Fort Belvoir, VA: Defense Technical Information Center, January 2011. http://dx.doi.org/10.21236/ada537395.

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