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Relevant bibliographies by topics / Drugs Drugs Suppositories

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Academic literature on the topic 'Drugs Drugs Suppositories'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Drugs Drugs Suppositories"

1

Murakami, Satoshi, Hidenori Takahashi, and Naohito Shimoyama. "Drug delivery system in pain control Suppositories, oral transmucosal drugs, nebulized drugs, another newly developed drugs." Drug Delivery System 20, no. 5 (2005): 538–42. http://dx.doi.org/10.2745/dds.20.538.

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Saeed, Ashti M. H., Maryam H. Alaayedi, and Athmar Dh H. Alshohani. "NEW COMBINATION SUPPOSITORIES OF LORNOXICAM AND ALOIN FOR RHEUMATOID ARTHRITIS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (February 1, 2018): 308. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.22921.

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Objective: The objective of our current work is to formulate, optimize and evaluate new combination rectal suppositories as a treatment for rheumatoid arthritis that contains both lornoxicam and aloin. Both are strong anti-inflammatory agents, and a combination of both may have synergistic effect as an anti-inflammatory treatment.Methods: Rectal suppositories containing 8 mg lornoxicam and 200 mg aloin were formulated by heat fusion method. Different combinations of different molecular weights of polyethylene glycol (PEG) were used for the formulated suppositories. The formulated suppositories were evaluated for their visual appearance, weight variation, hardness, friability, disintegration time, melting temperature, and drug content uniformity.Results: All the formulations prepared were within the required limits for USP. When the release study was performed, both drugs were released from all the formulations prepared. However, formulation F7 which is composed of PEG 400 30.88% (w/w): PEG 4000 46.32% (w/w) was superior to other formulations in which more than 80% of both drugs loaded were released after 35 min. The presence of both drugs in the same suppository did not affect their release.Conclusion: A new combination suppositories have been obtained where the two combined drugs were released fast without interference with each other release. The proposed new combination has the potential to be used as a strong analgesic and anti-inflammatory treatment compared to using lornoxicam or aloin alone.

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3

Hermann, T. W. "Recent research on bioavailability of drugs from suppositories." International Journal of Pharmaceutics 123, no. 1 (August 1995): 1–11. http://dx.doi.org/10.1016/0378-5173(95)00053-l.

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Orlova, T. V., T. A. Pankrusheva, A. V. Nesterova, and N. D. Ogneshchikova. "Biopharmaceutical study of suppositories containing nonsteroidal anti-inflammatory drugs." Pharmaceutical Chemistry Journal 44, no. 5 (October 2010): 265–67. http://dx.doi.org/10.1007/s11094-010-0445-2.

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Sergey Yu. Smolentsev, Ivan I. Kalyuzhny, Alexander M. Semivolos, Alla V. Egunova, Aleksandr M. Gertman, Andrey A. Elenshleger, Ivan A. Nikulin, and Yuriy N. Alekhin. "Use of Flunex and Ceftonite drugs for inflammation of the uterus in cows." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (July 27, 2020): 4235–39. http://dx.doi.org/10.26452/ijrps.v11i3.2634.

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Currently, in connection with the active development of dairy farming in Russia, the main requirement is to increase the dairy productivity of cattle and improve the quality of primary products. Despite the successes achieved in studying the causes of the development and pathogenesis of endometritis, the development of prevention methods, the frequency of their manifestation, especially in highly productive dairy herds, has no tendency to decrease. We conducted an experiment to study the effectiveness of the Flunex biogenic preparation with the Ceftonite gynecological suppositories in a comparative aspect with other known preparations with acute catarrhal-purulent endometritis. When conducting the experiment, before determining the therapeutic efficacy of the above drugs, anamnestic data were collected, the general condition, fatness and physique of the animal were determined. When using the tissue preparation Flunex with the gynecological suppositories Ceftonite for therapeutic purposes, with acute catarrhal-purulent endometritis of cows, recovery is faster than when using natural colostrum in combination with ichthyol suppositories.

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Špaglová, M., M. Čuchorová, M. Čierna, V. Mikušová, K. Bauerová, and S. Poništ. "Possibilities of microemulsion application in rectal administration of indomethacin." European Pharmaceutical Journal 68, no. 1 (January 1, 2021): 94–97. http://dx.doi.org/10.2478/afpuc-2021-0012.

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Abstract Rectal administration is a suitable route of administration for drugs that are either very irritating to the intestine (e.g., indomethacin) or are more effective when the first-pass effect in the liver is circumvented. Microemulsions are a tool for the improvement of penetration of sparingly soluble drugs. They are mainly used in topical and transdermal drug delivery. However, they find application also in other routes of administration, mainly due to their ability to solubilize sparingly soluble drugs. The selection of a suppository base depends on the physical properties of the drug. The study focused on evaluating the effect of the microemulsion as the solubilizer of sparingly soluble indomethacin in hydrophilic and lipophilic suppository bases compared with Polysorbate 80 as the excipient contained in the microemulsion. The reference suppositories were prepared by the traditional moulding technique from Adeps solidus or Macrogol suppository base without the previous drug solubilization. The microemulsion-based suppositories were prepared after the initial solubilization of the drug in the microemulsion or Polysorbate 80, followed by the addition of suppository base to maintain the same drug/solubilizer ratio. The suppositories were tested for softening time, hardness, and uniformity of mass. The dissolution test was performed using the dialysis tubing method in the basket apparatus. The amount of indomethacin released into the dissolution medium was determined spectrophotometrically at 320 nm. The results indicate that solubilization of indomethacin in the microemulsion had a positive effect on in vitro drug release but not as significant as in the case of Polysorbate 80 used alone. The enhancement ratio for Polysorbate 80 in Adeps suppositories was 2.9, for the microemulsion in Adeps suppositories was 1.1, and for Polysorbate 80 in Macrogol suppositories was 7.4 after 3 hours. The test of uniformity of mass had shown that all suppositories (reference, solubilizer-containing) are within the permitted limits. The softening time was reduced by adding the solubilizer to each type of suppository base.

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Hermann, Jacek, and Tadeusz Hermann. "BIOAVAILABILITY OF DRUGS FROM SUPPOSITORIES IN CLINICAL PRACTICE AFTER 1995." Acta Poloniae Pharmaceutica - Drug Research 77, no. 3 (June 29, 2020): 417–21. http://dx.doi.org/10.32383/appdr/123017.

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Persaud, Suzanne, Sandra Eid, Natalia Swiderski, Ioannis Serris, and Hyunah Cho. "Preparations of Rectal Suppositories Containing Artesunate." Pharmaceutics 12, no. 3 (March 2, 2020): 222. http://dx.doi.org/10.3390/pharmaceutics12030222.

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Rectal artesunate suppositories are a useful option for pre-referral treatment of severe malaria, specifically in children under 6 years of age in remote malaria-endemic areas. The main challenges are to improve the solubility of drugs in the rectal fluids and prevent the product from turning rancid or melting in a tropical climate. In this short proof-of-concept study, three types of rectal suppositories of artesunate were prepared: (i) polyethylene glycol (PEG)-based suppositories carrying free artesunate (non-modified artesunate), (ii) PEG-based suppositories carrying artesunate-loaded micelles and (iii) 3D-printed suppositories carrying a PEG/artesunate mixture. Physical parameters of suppositories, release profiles of artesunate (the fastest to the slowest: ii≥i>iii) and thermostability (the most stable to the least stable: iii>ii>i) of suppositories at increased temperature were assessed to determine the advantages and disadvantages of each formulation.

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Ye. Borko, I. Kovalevska, and O. Ruban. "The Marketing Research of the Pharmaceutical Market of Ukraine about the Prospects of Creation a New Medical Form." Herald of the Economic Sciences of Ukraine, no. 2(37) (December 23, 2019): 137–42. http://dx.doi.org/10.37405/1729-7206.2019.2(37).137-142.

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The aim of the work was a marketing research of the nomenclature of medicines presented on the pharmaceutical market of Ukraine, which are used to treat diseases of the anorectal zone. The work used graphic, system, marketing and pharmacoeconomic analysis methods. According to medical statistics in Ukraine, there is a rapid increase in the percentage of patients with pathologies of the anorectal zone among people of working age. The reasons for this phenomenon is the lifestyle of a modern person, which leads to an unbalanced diet, a decrease in physical activity and untimely treatment of existing diseases. The great variability of the symptomatic manifestation of pathological processes in diseases of the anorectal zone requires the appointment of effective treatment with groups of drugs with different pharmacological activity. When analyzing the assortment of drugs used to treat diseases of the anorectal zone, it was found that 117 pharmaceutical preparations in various dosage forms were presented on the pharmaceutical market of Ukraine; of which the proportion of suppositories is 17.09%. When analyzing the origin of the main active ingredients of suppositories, it was found that the largest share is made up of active substances of synthetic origin (60%), herbal components are present in 25% of the analyzed preparations, a combination of substances of plant and synthetic origin account for 15%. An analysis of the origin of the manufacturing company allows us to conclude that the share of medicines manufactured in Ukraine is 50%, and the range is presented to foreign manufacturers from Germany, Poland, France, Serbia and Italy. The results obtained indicate that, according to the recommendations for the use of drugs, a treatment course of 1 week is rational. An analysis of treatment regimens suggests that the use of a combination of several drugs from different pharmacological groups significantly increases the total cost and reflects a lack of compliance. The analysis of drugs used to treat diseases of the anorectal zone. The assortment of drugs was studied by the form of release, the origin of the manufacturer, the composition of the dosage form, the origin of the main components and pricing policy. It was found that there is a lack of rectal suppositories of a combined composition that could be used to treat these pathologies. Therefore, as a result of the study, it was concluded that the creation of a new drug for the safe and effective treatment of diseases of the anorectal zone is advisable and relevant. Keywords marketing analysis; pharmaceutical market of Ukraine; diseases of the anorectal zone; suppositories.

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Jhunjhunwala, Kunal, Charles W. Dobard, Sunita Sharma, Natalia Makarova, Angela Holder, Chuong Dinh, James Mitchell, et al. "Development, Characterization and In Vivo Pharmacokinetic Assessment of Rectal Suppositories Containing Combination Antiretroviral Drugs for HIV Prevention." Pharmaceutics 13, no. 8 (July 21, 2021): 1110. http://dx.doi.org/10.3390/pharmaceutics13081110.

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Receptive anal intercourse (RAI) contributes significantly to HIV acquisition underscoring the need to develop HIV prevention options for populations engaging in RAI practices. We explored the feasibility of formulating rectal suppositories with potent antiviral drugs for on-demand use. A fixed-dose combination of tenofovir (TFV) and elvitegravir (EVG) (40 mg each) was co-formulated in six different suppository bases (three fat- and three water-soluble). Fat-soluble witepsol H15 and water-soluble polyethylene glycol (PEG) based suppositories demonstrated favorable in vitro release and were advanced to assess in vivo pharmacokinetics following rectal administration in macaques. In vivo drug release profiles were similar for both suppository bases. Median concentrations of TFV and EVG detected in rectal fluids at 2 h were 1- and 2-logs higher than the in vitro IC50, respectively; TFV-diphosphate levels in rectal tissues met or exceeded those associated with high efficacy against rectal simian HIV (SHIV) exposure in macaques. Leveraging on these findings, a PEG-based suppository with a lower dose combination of tenofovir alafenamide (TAF) and EVG (8 mg each) was developed and found to achieve similar rectal drug exposures in macaques. This study establishes the utility of rectal suppositories as a promising on-demand strategy for HIV PrEP and supports their clinical development.

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Dissertations / Theses on the topic "Drugs Drugs Suppositories"

1

Mollel, Happiness. "Development and assessment of azithromycin paediatric suppository formulations." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1345/.

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Book chapters on the topic "Drugs Drugs Suppositories"

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Regdon, G., I. Bácskay, Á. Gergely, K. Hódi, G. Regdon, and M. Kata. "Influence of Cyclodextrins on the in Vitro Drug Liberation of Rectal Suppositories Containing Benzodiazepine Derivates." In Proceedings of the Eighth International Symposium on Cyclodextrins, 435–38. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_96.

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Waldmann, Carl, Andrew Rhodes, Neil Soni, and Jonathan Handy. "Gastrointestinal drugs." In Oxford Desk Reference: Critical Care, 205–15. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198723561.003.0013.

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This chapter discusses gastrointestinal drugs and includes discussion on H2 blockers and proton pump inhibitors (including discussion on physiology of acid secretion, pharmacology, pathophysiology of stress ulcers, stress ulcer prophylaxis, and treatment of acute bleeding after endoscopy), antiemetics (including discussion on mechanisms of nausea and vomiting, antiemetic drugs, and clinical approach), gut motility agents (indications, erythromycin, erythromycin versus metoclopramide, metoclopramide, domperidone, cisapride, neostigmine, and alternative treatment strategies), antidiarrhoeals (risk factors and causes of diarrhoea, antidiarrhoeal drugs, and enteral supplements), and constipation in critical care. This includes pathophysiology of and risk factors for constipation, treatments including bulk-forming, stimulating, osmotic, and emollient laxatives, as well as suppositories and enemas, motility agents, and opioid antagonists. It also outlines special circumstances, including palliative care, spinal cord injury, and liver failure patients.

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Hillman, David. "Drugs, Suppositories, and Cult Worship in Antiquity." In History of Toxicology and Environmental Health, 60–67. Elsevier, 2015. http://dx.doi.org/10.1016/b978-0-12-801506-3.00006-6.

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Hillman, David. "Drugs, Suppositories, and Cult Worship in Antiquity." In Toxicology in Antiquity, 335–42. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-815339-0.00023-8.

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Ainsworth, Sean. "E." In Neonatal Formulary, edited by Sean Ainsworth, 275–307. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198840787.003.0018.

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This chapter presents information on neonatal drugs that begin with E, including use, pharmacology, adverse effects, fetal and infant implications of maternal treatment, treatment, and supply of Enemas, laxatives, and suppositories, Enoxaparin, Enzyme replacement therapy, Epoetin (recombinant human erythropoietin = rEPO), Epoprostenol and other prostanoids (iloprost and teoprostinil), Erythromycin, Esomeprazole, Ethambutol, and Eye drops (and ointments)

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Bashaw, Edward. "Bioavailability and Bioequivalence Issues for Drugs Administered via Different Routes of Administration; Inhalation/Nasal Products; Dermatological Products, Suppositories." In Drugs and the Pharmaceutical Sciences, 475–502. CRC Press, 2004. http://dx.doi.org/10.1201/9780203026427.ch20.

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"Bioavailability and Bioequivalence Issues for Drugs Administered via Different Routes of Administration; Inhalation/Nasal Products; Dermatological Products, Suppositories." In New Drug Development, 430–55. CRC Press, 2004. http://dx.doi.org/10.1201/9780203026427-27.

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8

"Rectal Dosage Forms and Suppositories." In Generic Drug Product Development, 116–41. CRC Press, 2016. http://dx.doi.org/10.3109/9781420020038-7.

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Iwata, M., S. Shirotake, F. Hirahara, H. Minaguchi, Y. Machida, and T. Nagai. "DEVELOPMENT AND CLINICAL EVALUATION OF DOUBLE-PHASED SUPPOSITORIES OF PROGESTERONE WITH SUSTAINED RELEASE PROPERTY." In Advances in Drug Delivery Systems, 6, 323–24. Elsevier, 1994. http://dx.doi.org/10.1016/b978-0-444-82027-3.50056-0.

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Conference papers on the topic "Drugs Drugs Suppositories"

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Farida, Siti, Nurul Azizah, Heri Hermansyah, and Muhamad Sahlan. "Production and characterization of vaginal suppositories with propolis wax as active agent to prevent and treat Fluor albus." In BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the First International Symposium of Biomedical Engineering (ISBE 2016). Author(s), 2017. http://dx.doi.org/10.1063/1.4976782.

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