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Journal articles on the topic 'DRUGS LTD'

Author: Grafiati

Published: 11 September 2023

Last updated: 31 July 2025

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1

Sri, D. Soumya, and N. Uday Kumar. "Quality Of Work Life At Hetero Drugs Ltd." Think India 22, no. 3 (2019): 370–76. http://dx.doi.org/10.26643/think-india.v22i3.8265.

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Quality of Work Life is the object of a unmixed old of organizational announcement or protocol. This definiteness repeatedly argues zigzag a snobbish aerate of move ricochet exists honest away republican delivery customs are refuse-me-down , order member’s jobs are enriching, lift are predisposed encircling respectability and safe effectual circulation exist.

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Zaman, Muhammad H., and Tarun Khanna. "The Cost and Evolution of Quality at Cipla Ltd., 1935–2016." Business History Review 95, no. 2 (2021): 249–74. http://dx.doi.org/10.1017/s000768052000077x.

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This article examines the evolution of Indian pharmaceutical manufacturer Cipla toward producing drugs that met the quality standards of European and U.S. regulators. It employs new research in both Cipla's corporate archives and a wide range of oral histories. The article argues that, along with a long-standing corporate culture of self-reliance rooted in nationalism starting from the company's inception in 1935, major factors in Cipla's strategy from the 1960s through the early 2000s included the early adoption and continued use of quality-control technology, along with efforts to create glo

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Tanaka, E., E. Inoue, R. Sakai, I. Katsuhiko, A. Shoji, and M. Harigai. "POS0554 MEDICAL COST AND RESOURCE USE IN PATIENTS STARTING TREATMENT FOR RHEUMATOID ARTHRITIS TREATED WITH AND WITHOUT CORTICOSTEROIDS IN JAPAN." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 511.2–512. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2805.

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Background:The 2019 update of the European League Against Rheumatism (EULAR) treatment recommendations strongly recommends co-administration of corticosteroids (CSs) with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in patients with RA as bridging therapy to improve the success rate of the first-line treatment and to avoid disease flare-ups1; however, current treatment guidelines for RA in Japan do not clearly mention about their use. Poor disease management after the initial diagnosis can affect the overall use of health services and the economic burden on patients.

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Tanaka, E., E. Inoue, R. Sakai, I. Katsuhiko, A. Shoji, and M. Harigai. "POS0551 MEDICAL COSTS FOR PATIENTS STARTING TREATMENT FOR RHEUMATOID ARTHRITIS WHO HAVE COMORBID DIABETES MELLITUS IN JAPAN." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 510.1–510. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2770.

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Background:Rheumatoid arthritis (RA) patients can experience various comorbidities1. The incidence of diabetes mellitus (DM) is reported higher in patients with RA2 and comorbid DM is likely to affect treatment outcomes3 and then healthcare resource uses, however, no previous study has not focused on it.Objectives:To evaluate medical costs and resource use in patients starting treatment for RA with and without DM using a large claims database in Japan.Methods:We used a large Japanese administrative claims database constructed by the Japan Medical Data Center (JMDC)4. Patients with the Internat

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Kojima, Yuki, Fumihiko Hayakawa, Takanobu Morishita, et al. "YM155 Induces Apoptosis through Proteasome-Dependent Degradation of MCL-1 in Primary Effusion Lymphoma." Blood 128, no. 22 (2016): 3013. http://dx.doi.org/10.1182/blood.v128.22.3013.3013.

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Abstract Primary effusion lymphoma (PEL) is a subtype of non-Hodgkin lymphoma caused by human herpes virus 8 (HHV-8), which mainly occurs in patients with acquired immunodeficiency. It is highly refractory to conventional chemotherapies, and has a very poor prognosis. We recently developed patient-derived xenograft (PDX) screening, a novel high-throughput drug screening system using PDX cells that were established by transplantations of primary tumor cells into immunodeficient mice and maintained primary cell phenotype. PDX screening is expected to discover anti-tumor drugs that have been over

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Thomas, Mark J., and Robert C. Malenka. "Synaptic plasticity in the mesolimbic dopamine system." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 358, no. 1432 (2003): 815–19. http://dx.doi.org/10.1098/rstb.2002.1236.

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Long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical mechanisms that contribute to the neural circuit modifications that mediate all forms of experience-dependent plasticity. It has, however, been difficult to demonstrate directly that experience causes long-lasting changes in synaptic strength and that these mediate changes in behaviour. To address these potential functional roles of LTP and LTD, we have taken advantage of the powerful in vivo effects of drugs of abuse that exert their behavioural effects in large part by acting in the nucleus accumbens (NAc)

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Higuchi, T., E. Tanaka, E. Inoue, et al. "AB0286 RETENTION RATE OF BIOLOGIC DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH DECREASED KIDNEY FUNCTION: RESULTS FROM THE IORRA COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1324. http://dx.doi.org/10.1136/annrheumdis-2023-eular.374.

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BackgroundWe previously reported that rheumatoid arthritis (RA) patients with chronic kidney disease (CKD) were at increased risk of failure to achieve remission and of occurrence of hospitalized infections [1]. Although biologic disease-modifying anti-rheumatic drugs (bDMARDs) are a promising treatment option, their effectiveness and safety for this population have not been fully evaluated to date.ObjectivesTo determine the optimal bDMARD selection for treatment of RA patients with decreased kidney function, we compared the retention rates of patients receiving tumor necrosis factor inhibitor

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Wright, W. B. "Drugs, ageing, and society Burns Bruce Phillipson Chris Drugs, ageing, and society Croom Helm Ltd, Beckenham, 1986, 180pp, H/B, £19.95." Elderly Care 7, no. 4 (1987): 28. http://dx.doi.org/10.7748/eldc.7.4.28.s27.

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9

Saliy, O. O., and M. O. Sinchuk. "DEVELOPMENT OF APPROACHES TO LABORATORY CONTROL OF «BIOTESTLAB» LTD TO ENSURE QUALITY OF VETERINARY PREPARATIONS." Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology 22, no. 2 (2021): 331–38. http://dx.doi.org/10.36359/scivp.2021-22-2.39.

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The article presents the development of approaches to laboratory control and the results of research related to the standardization of methods at Ltd "BIOTESTLAB" to ensure the quality of veterinary drugs. Attention is paid to the methods of biological quality control of veterinary drugs: microbiological purity, hemagglutination reaction (HAR), determination of infectious activity of embryonic vaccines. Because such methods are characterized by low automation, low accuracy, the impact on the result of error due to personnel performing operations manually, the lack of regulatory approaches to v

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Derkach, I. "Сучасні тенденції на вітчизняному ринку ферумвмісних препаратів для тварин". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 19, № 78 (2017): 23–25. http://dx.doi.org/10.15421/nvlvet7805.

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The article presents an analysis of the domestic market of veterinary preparations of Ferum. It is established that nowadays it is represented by 13 drugs of the following group: QV03A Antianemic agents. Preparations of iron, according to ATS-vet classification. Assortment of 38% is provided by pharmaceutical goods of Ukrainian producers: «O.L.KAR-AgroZoOvetService», PP Farmaton, LLC «BROVAFARMA», Ltd. «Research and experimental production Institute of Epizootology», PP «BIOFARM», LLC «Vetsintez». Imported products (62%) are presented by Pharmacosmos A/S (Kingdom Denmark), MERIEL, KOOFAVET C.A

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Jaquette, Ian. "Merck KGaA v. Integra Lifesciences I, Ltd: Implications of the Supreme Court's Decision for the People Who Matter Most … the Consumer." American Journal of Law & Medicine 33, no. 1 (2007): 97–117. http://dx.doi.org/10.1177/009885880703300103.

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Sales of brand and generic pharmaceuticals in the United States reached $274.7 billion in 2006. Consumers in this country, including the federal government, are paying tremendous amounts of money for drugs and the cost continues to be a growing concern for all parties involved. Part of this increased cost encountered by consumers can be directly attributed to the ever-increasing costs manufacturers must cope with in the development of new drugs. Economists estimate that it takes twelve to fifteen years to develop a single new drug and have it approved by the Food and Drug Administration (“FDA”

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Rybachuk, Zh V., I. V. Prisyazhnyuk, and K. O. Chirta-Sinelnyk. "“EMBIOTIC” Ltd. “EM-Ukraine” – an alternative to antibiotic therapy for digestive disorders in calves." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 23, no. 102 (2021): 8–13. http://dx.doi.org/10.32718/nvlvet10202.

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The prophylactic efficacy of diarrhea in calves with different methods and doses of feed additive “EMBIOTIC” during the first 14 days of life was studied. Almost 50 % of dairy calves had symptoms of diarrhea. Effective treatment regimens for such animals included one of the antibiotics (azithromycin or 15 % amoxicillin emulsion) and, if necessary, sulfonamide drugs (trimeratinvet with the drugs sulfadimesine and trimethoprim) or the drug sulfate lozin, which includes sulfonamide and antibiotics (tylosin tartrate, oxytetracycline, sulfadimesine, trimethoprim). Simultaneously, symptomatic therap

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Poteshkina, N. G., and A. A. Troshina. "Torasemid in the treatment of cardiovascular disease: the optimal use in conditions of comorbidity." Systemic Hypertension 12, no. 4 (2015): 38–41. http://dx.doi.org/10.26442/sg29113.

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The article reviews the current clinical data on the use of one of the modern pharmacological drugs torasemide (Diuver, Teva Pharmaceutical Industries Ltd., Israel) in the treatment of cardiovascular disease in conditions of comorbidity. Presents a comprehensive view of the problem identified and a reasoned approach to the choice of diuretic therapy with clinico-pathophysiological substantiation of the use of a loop diuretic torasemid. Conceptually formed of a number of provisions on the application of one of the modern diuretic drugs in therapeutic practice in patients with arterial hypertens

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14

Ochiai, M., E. Tanaka, E. Inoue, et al. "THU0144 DESCRIPTIVE ANALYSIS OF PREGNANCY, DELIVERY, AND LACTATION IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM THE IORRA COHORT." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 287–88. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2692.

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Background:Rheumatoid Arthritis (RA) is common in women with reproductive age. For this reason, RA treatment during pregnancy and lactation is very important. In recent years, the use of biologic disease-modifying antirheumatic drugs (bDMARDs) has become common in RA treatment (1), treatment during pregnancy and lactation has changed drastically (2,3).Objectives:To investigate the pregnancy, delivery and lactation status of RA patients and treatment during that period in daily practice.Methods:The IORRA cohort is a large, single institute-based, observational cohort of RA patients established

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15

Jabbar, Alhasan A., Israa Al-Ani, Ramadan I. Al-Shdefat, Nadia Ghazal, Anwar Jaffal та Mohamed H. Fayed. "Design of Experiment Approach for Enhancing the Dissolution Profile and Robustness of Loratadine Tablet Using D-α-Tocopheryl Polyethylene Glycol 1000 Succinate". Pharmaceutics 17, № 3 (2025): 380. https://doi.org/10.3390/pharmaceutics17030380.

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Background: Formulating poorly water-soluble drugs poses significant challenges due to their limited solubility and bioavailability. Loratadine (LTD), classified as a BCS II molecule, exhibits notably low solubility, leading to reduced bioavailability. Objective: This study aims to enhance the dissolution rate of LTD through the utilization of the wet granulation process using Tocopheryl polyethylene glycol 1000 succinate (TPGS). Methods: A Design-of-Experiment methodology was adopted to investigate and optimize the formulation variables for preparing an oral delivery system of LTD with improv

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16

Linden, David J. "A late phase of LTD in cultured cerebellar Purkinje cells requires persistent dynamin-mediated endocytosis." Journal of Neurophysiology 107, no. 1 (2012): 448–54. http://dx.doi.org/10.1152/jn.00824.2011.

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Long-term synaptic depression (LTD) of cerebellar parallel fiber-Purkinje cell synapses is a form of use-dependent synaptic plasticity that may be studied in cell culture. One form of LTD is induced postsynaptically through an mGlu1/Ca influx/protein kinase Cα (PKCα) cascade, and its initial expression requires phosphorylation of ser-880 in the COOH-terminal PDZ-ligand region of GluA2 and consequent binding of PICK1. This triggers postsynaptic clathrin/dynamin-mediated endocytosis of GluA2-containing surface AMPA receptors. Cerebellar LTD also has a late phase beginning 45–60 min after inducti

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17

Bach, K. B., та G. S. Mitchell. "Hypercapnia-induced long-term depression of respiratory activity requires α2-adrenergic receptors". Journal of Applied Physiology 84, № 6 (1998): 2099–105. http://dx.doi.org/10.1152/jappl.1998.84.6.2099.

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We investigated the effects of repeated hypercapnic episodes (inspired CO2fraction = 0.10) on posthypercapnic respiratory nerve discharge. Anesthetized (urethan), vagotomized, and artificially ventilated rats were presented with three consecutive 5-min episodes of hyperoxic hypercapnia, separated by 5 min of hyperoxic normocapnia (inspired O2 fraction = 0.5). Respiratory nerve discharge and blood gases were recorded before and 30 and 60 min after the final hypercapnic episode. Posthypercapnia, arterial[Formula: see text] was maintained within 1 Torr of initial baseline values. Integrated phren

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18

Rees, Sharon. "Drug Breakdown: ACAMPROSATE." Journal of Prescribing Practice 6, no. 11 (2024): 446–47. http://dx.doi.org/10.12968/jprp.2024.0033.

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In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of posts on X. This month she is talking about #acamprosate With the help of Prescribing and Therapeutics Training Ltd and the Journal of Prescribing Practice, you can earn your 1-hour CPD certificate

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19

Venetikou, Maria S., Jacky M. Burrin, Christine A. Woods, Tom H. Yeo, Judith Brownell, and Eric F. Adams. "Effects of two novel dopaminergic drugs, CV 205-502 and CQP 201-403, on prolactin and growth hormone secretion by human pituitary tumours in vitro." Acta Endocrinologica 116, no. 2 (1987): 287–92. http://dx.doi.org/10.1530/acta.0.1160287.

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Abstract. Two novel dopaminergic drugs, designated CV 205-502 and CQP 201-403 have recently been developed by Sandoz Pharmaceuticals Ltd (Basle, Switzerland). The effects of these drugs on PRL and GH secretion by normal rat and tumorous human pituitary cells in vitro have been investigated. Low doses of both CV 205-502 and CQP 201-403 immediately and profoundly suppressed PRL secretion, which failed to recover up to 7 h after removal of the drugs. Similarly, CQP 201-403 significantly suppressed basal GH secretion by human pituitary somatotropic tumours in culture, and both drugs significantly

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Radaeva, K. S., and A. S. Kolbin. "International experience in drug assessment for rare diseases: flexibility of approaches." Real-World Data & Evidence 4, no. 2 (2024): 3–12. http://dx.doi.org/10.37489/2782-3784-myrwd-52.

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Relevance. The regulation of orphan drugs plays a key role in the development of medicines for rare diseases that affect only a small percentage of the population. This specialized regulatory framework is designed to encourage pharmaceutical companies to allocate resources to the development of drugs for diseases that might otherwise be overlooked due to limited commercial appeal. Experts from Cogentia Healthcare Consulting Ltd. analyzed trends in the assessment of orphan drugs in the UK.Objective. The aim of this work was to analyze and present the main trends in the optimization of decision-

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21

Kawazoe, M., K. Aoki, W. Hirose, et al. "AB1328 LONGITUDINAL SEROLOGICAL STUDY OF ANTI-SARS-CoV-2 SPIKE PROTEIN ANTIBODIES AFTER TWO DOSES OF mRNA VACCINES IN PATIENTS WITH RHEUMATIC DISEASES: ANALYSIS OF EFFECTS OF IMMUNOSUPPRESSANT THERAPY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1893.1–1894. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1217.

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BackgroundThe longitudinal efficacy and safety data of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with rheumatic disease (RD) remains unclear.ObjectivesThe objective of the study was to examine changes over time in anti-SARS-CoV-2 spike protein IgG (anti-S IgG) values in RD patients compared with controls and investigate the effects of immunosuppressants on the values. Safety of vaccine was also evaluated.MethodsRD patients receiving glucocorticoids or immunosuppressants who were scheduled to receive two doses of SARS-CoV-2 mRNA vaccines were incl

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Hindmarch, Ian. "Psychiatric drugs explained D. Healy. Mosby?Yearbook Ltd., 1993. 284 pp. �7.95. ISBN 0-7234-1845-4." Human Psychopharmacology: Clinical and Experimental 8, no. 4 (1993): 293. http://dx.doi.org/10.1002/hup.470080410.

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23

Rae, Ian D. "Responses by Australian pharmacologists to respiratory depression caused by opiates and barbiturates." Historical Records of Australian Science 33, no. 1 (2022): 1–11. http://dx.doi.org/10.1071/hr21005.

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In the middle of the last century, pharmacologists at the University of Melbourne led by Professor Frank Shaw inadvertently discovered that an amino-acridine they were using in other experiments reversed the respiratory depressive effects of morphine. They widened their search for such activity, experimenting with a range of heterocyclic substances and achieving success with a thiazole derivative, provided to them by the Professor of Organic Chemistry at the university, that countered the effects of morphine. Working with chemists and pharmacologists at a company with which Shaw had close link

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Burattini, Costanza, Giulia Battistini, Francesco Tamagnini, and Giorgio Aicardi. "Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid." Journal of Neurophysiology 111, no. 5 (2014): 1046–55. http://dx.doi.org/10.1152/jn.00498.2013.

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The nucleus accumbens (NAc), a major component of the mesolimbic system, is involved in the mediation of reinforcing and addictive properties of many dependence-producing drugs. Glutamatergic synapses within the NAc can express plasticity, including a form of endocannabinoid (eCB)-long-term depression (LTD). Recent evidences demonstrate cross talk between eCB signaling pathways and those of other receptor systems, including serotonin (5-HT); the extensive colocalization of CB1 and 5-HT receptors within the NAc suggests the potential for interplay between them. In the present study, we found th

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25

West, Robert. "Say Why to Drugs: Everything You Need to Know About the Drugs We Take and Why We Get HighSuziGageLondon: Hodder & Stoughton Ltd, 2020, ISBN: 9781473686229." Addiction 115, no. 10 (2020): 1980–81. http://dx.doi.org/10.1111/add.15034.

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Takanashi, S., Y. Kaneko, and T. Takeuchi. "FRI0079 CHARACTERISTICS OF DIFFICULT-TO-TREAT RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 616.2–617. http://dx.doi.org/10.1136/annrheumdis-2020-eular.872.

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Background:Despite remarkable progress in therapy, not a few patients with rheumatoid arthritis (RA) have not achieved treatment target. Various factors can be ascribed to difficult-to-treat RA, however, little is known about their characteristics.Objectives:To clarify characteristics of patients with difficult-to-treat RA in real-world.Methods:We reviewed all consecutive RA patients in Keio University Hospital between 2016 and 2017 and collected medical information. We defined patients in moderate disease activity and high disease activity according to disease activity score for 28 joints (DA

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Novak, Barbara V. "How Drugs Work – Basic Pharmacology for Healthcare Professionals Hugh McGavock Published by Radcliffe Publishing Ltd (Third Revised Edition)." Nurse Prescribing 9, no. 2 (2011): 88. http://dx.doi.org/10.12968/npre.2011.9.2.88.

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28

Morishita, Takanobu, Fumihiko Hayakawa, Keiki Sugimoto, et al. "A Photosensitizer Verteporfin Has Light-Independent Anti-Leukemic Activity for Ph-Positive Acute Lymphoblastic Leukemia and Synergistically Works with Dasatinib in Vivo." Blood 126, no. 23 (2015): 1331. http://dx.doi.org/10.1182/blood.v126.23.1331.1331.

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Abstract Despite of great improvement of treatment outcome by ABL kinase inhibitors, Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is still intractable disease, and novel therapeutic agents are anticipated. We recently developed a high-throughput drug screening system using patient-derived xenograft (PDX) cells. PDX cells highly maintain phenotypes of primary malignant cells, such as heterogeneity of cancer cells, slower growth rate than cell lines, and microenvironment dependency. Drug screening by PDX cells can pick up anti-tumor reagents with new mechanisms that we

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Banjo, Toshihiro, Yasuhiro Hama, Emi Nosaka, et al. "EZH1/2 Dual Inhibitor Valemetostat Tosylate (DS-3201b) Acts Differently from EZH2 Selective Inhibitor on Epigenetic Landscape to Exert Greater Anti-Tumor Effect Against Diffuse Large B-Cell Lymphoma." Blood 138, Supplement 1 (2021): 2948. http://dx.doi.org/10.1182/blood-2021-146772.

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Abstract Enhancer of zeste homologous (EZH) 2 and its close homolog EZH1 are catalytic subunits of polycomb repressive complex (PRC) 2 protein complex, and play redundant and crucial role for the maintenance of transcriptional repression by tri-methylating histone H3 lysine 27 (H3K27). Hyper trimethylation of H3K27 has been associated with malignant lymphoma and myeloma progression, thus several small molecules suppressing PRC2 complex activity has been developed for hematological malignancy therapy. We have developed valemetostat tosylate (DS-3201b, also known as valematostat), a potent dual

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Wisam T. Hammadi and Sarhan A. Salamn. "Spectrophotometric Determination, Analysis And Validation Of Acyclovir 0n Solid Dosage Form." International Journal of Medicine and Health 3, no. 2 (2024): 06–13. http://dx.doi.org/10.55606/ijmh.v3i2.3102.

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A new, economical, sensitive, simple, rapid UV spectrophotometric method has been developed for the estimation of Acyclovir in pure form and pharmaceutical formulation. This UV method was developed using NaOH (0.1N) as a solvent. In the present method, the wavelength selected for analysis was 253nm. Using 1cm match quartz cells, all of the spectrum and absorbance measurements were performed using an UV-VIS spectrophotometer (Shimadzu 1800) was used to carry out the spectral analysis. The ICH guidelines were used to validate the method. Throughout the study, we compared the purity of the drugs,

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Balitska, O., V. Zlahoda, Yu Hryhoruk, and O. Cordon. "The pharmacoepidemiological analysis of the influenza pharmacotherapy in Ukraine." Management, economy and quality assurance in pharmacy, no. 1(65) (March 15, 2021): 54–59. http://dx.doi.org/10.24959/uekj.21.3.

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Influenza and other acute respiratory viral infections (ARIs) are the most common among human diseases that require timely medical attention and treatment with the most effective drugs. The aim of the study is pharmacoepidemiological analysis of drugs for the treatment of influenza registered in Ukraine. Materials and methods of research. The study was based on data from the State Register of Medicines of Ukraine, information on the results of the epidemic season of influenza and acute respiratory infections of the Center for Public Health of the Ministry of Health of Ukraine, declared drugs u

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Cuddihy, Andrew R., Parisa Asvadi, Rosanne Dunn, Tiffany T. Khong, and Andrew Spencer. "The Anti-Kappa Monoclonal Antibody MDX-1097 Synergizes with Immunomodulatory Drugs to Enhance Antibody-Dependent Cell Cytotoxicity of Multiple Myeloma Cells." Blood 120, no. 21 (2012): 4012. http://dx.doi.org/10.1182/blood.v120.21.4012.4012.

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Abstract Abstract 4012 Multiple Myeloma (MM) is a cancer caused by the proliferation of malignant clonal plasma cells in the bone marrow and accounts for 10% of all hematologic malignancies. Recent advances have been made in the treatment and management of MM, however, despite these advances the majority of patients will ultimately relapse and die from their disease within 3–5 years from diagnosis. Several novel therapeutic approaches, including the use of antibody-based therapies, are being investigated to further improve the treatment of MM. MDX-1097 is a chimeric monoclonal antibody being a

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B., N. Roy, Kumar A., and Sankaran R. "Emerging trends in synthesis of drugs and fine chemicals." Journal of Indian Chemical Society Vol. 77, Oct 2000 (2000): 459–72. https://doi.org/10.5281/zenodo.5867617.

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Lupin Laboratories Ltd., 159 CST Road, Kalina, Santacruz (East), Mumbai-400 098, India <em>Manuscript received 24 April 2000, revised 17 July 2000, accepted 9 August 2000</em> Although, the discovery process for a pharmaceutical product requires management of various biological sciences and organic synthesis, but once a compound has satisfied therapeutic requirements and safety standards, the science involved is essentially organic synthesis, i.e. large-scale manufacture of the compound. Since, any synthesis/manufacture in today's context ought to <em>be </em>green, should not pollute

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Shelke, Ashwini, and Tushar Lokhande. "Desitometric Development and Validation for Simultaneous Determination of Antiretroviral Drugs Lamivudine, Zidovudine and Nevirapine in Fixed-Dose Combination Tablets." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 352–56. http://dx.doi.org/10.25258/ijddt.14.1.50.

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A cutting-edge high-performance thin layer chromatography (HPTLC) approach designed for simultaneous measurement of tablets containing drugs like lamivudine, nevirapine, and zidovudine. Chromatograms were performed employing chloroform and methanol (8:2 v/v) on pre-coated silica gel aluminum thin-layer chromatography (TLC) plates. The data was quantified using the optical density absorbance mode at 271 nm. The Rf values for lamivudine, zidovudine, and nevirapine were 0.140, 0.523, and 0.678, respectively. Linearity was found for lamivudine, zidovudine and nevirapine at concentrations of 150 to

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Sakai, R., E. Tanaka, M. Majima, and M. Harigai. "FRI0075 DECREASED RISKS OF HOSPITALIZED INFECTION UNDER TARGETED THERAPIES VS METHOTREXATE IN ELDERLY AND OLDER ELDERLY PATIENTS COMPARED TO YOUNGER PATIENTS WITH RHEUMATOID ARTHRITIS USING JAPANESE HEALTH INSURANCE DATABASE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 614–15. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1913.

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Background:Recently, vital prognosis has been improved in patients with rheumatoid arthritis (RA)1. In elderly patients, it is difficult to establish a treatment strategy due to multi-morbidities and treatment-related risks. Since older age is a significant risk factor of serious infections, one of the primary concerns during treatment of RA, rheumatologists should always strike a balance between efficacy and safety of the immunosuppressive treatment. However, infection data under the targeted therapy (TT) in elderly patients is still limited to date.Objectives:To compare the risk of hospitali

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Liu, Shanxi, Yanfeng Xiao, Jun Lv, et al. "Study on the Efficacy and Safety of Non-Factor Drugs Applied the Etiological Classification for Treatment of Hemophilia:a Multi-Centre, Prospective Single-Arm Clinical Trial." Blood 128, no. 22 (2016): 4986. http://dx.doi.org/10.1182/blood.v128.22.4986.4986.

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Abstract Objective: Research on the efficacy and safety of non-factor drugs applied the etiological classification for treatment of hemophilia. Diagnostic Methods: Between from June 2013 and June 2014, 73 patients were treated because of hemophilia. There were 69 males and 4 females, ages ranging from 0.4 to 83 years, with a mean of 16.13. We used MC-1000 Coagulometer (from MDC,Berlin, Germany) to detect the level of F¢ø/F¢ù:C, and detected the level of F¢ø/F¢ù inhibitor using Nigmegen assay. To detect mutations in the F8 and F9 gene, Intron 22 inversions were studied by inverse-shifting polym

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Tremblay, Johane. "Décisions rendues par le Conseil canadien des relations du travail." Relations industrielles 42, no. 4 (2005): 852–61. http://dx.doi.org/10.7202/050367ar.

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Au cours des derniers mois, le Conseil a rendu deux décisions importantes dans le secteur des postes. Le 29 avril, le Conseil reconnaissait aux facteurs ruraux le statut d'employé au sens du paragraphe 107(1) du Code canadien du travail, alors que le 1er septembre, il concluait qu'une vente d'entreprise était survenue par suite d'un contrat de franchise conclu entre la Société canadienne des postes et Sheldon Manly Drugs Ltd. Ces deux décisions qui font encore les manchettes seront résumées dans la présente chronique.

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Parol, Grover, Singh Jitender, L. Dhar K. та Mehta Lovekesh. "Synthetic modification of β-sitosterol with 2-amino-1,3,4,6-tetra-O-hydroxy-2- deoxy-β-D-glucopyranose hydrochloride". Journal of Indian Chemical Society Vol. 86, Oct 2009 (2009): 1112–14. https://doi.org/10.5281/zenodo.5820607.

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Lord Shiva College of Pharmacy, Sirsa-125 055, Haryana, India <em>E-mail </em>: parul.grvr@gmail.com l. S. F. College of Pharmacy, Moga, Punjab, India Ind-Swift Labs Ltd., Mohali, Punjab, India <em>Manuscript received 13 January 2009, revised 27 April 2009, accepted 3 June 2009</em> Coupling of β-sitosterol with glucosamine yields glucoside which has enhanced bioavailability due to number of polar groups present in the glucoside and is expected to possess enhanced anti-arthritic activity due to synergistic effects of both anti-arthritic drugs.

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E.I., Okoye, and Usiakpebru A.E. "Analysis of Antibiotics (Amoxicillin) and Anti-Hypertensive (Nifedipine) Drugs." Pharmaceutical and Chemical Journal 5, no. 1 (2018): 24–30. https://doi.org/10.5281/zenodo.13890262.

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This work analyzed ten capsules of amocycillin 500 mg each from drug resolving stores (shop 1), Opaclsas Pharmacy (shop 2), Happy Home Pharmacy (shop 3), Cheff Pharmacy Ltd (shop 4) Chimezie Medicine Stores (shop 5). The anti-hypertensive drugs (Nifedipine, 20 mg) were obtained from drug resolving stores (shop 1), Happy Home Pharmacy (shop 2), Cheff Pharmacy (shop 3), Chimezie Medicine stores (shop 4) and D-Global Pharmacy (shop 5). All capsules and tablets were obtained from different locations in Asaba. The analysis carried out on them are disintegration time, percentage uniformity of weight

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Anno, S., T. Okano, K. Inui, T. Koike, and H. Nakamura. "AB0235 DENOSUMAB INCREASE THE BONE MINERAL DENSITY REGARDLESS OF DISEASE ACTIVITY, THE BIOLOGICAL DISEASE-MODIFYING ANTIRHEUMATIC DRUGS, THE CONCOMITANT TYPE OF VITAMIN D, AND PRETREATMENT OF OSTEOPOROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1417.2–1418. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2538.

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Background:Osteoporosis is one of the major comorbidities in patients with rheumatoid arthritis (RA). There are a lot of evidence that denosumab increase bone mineral density (BMD) in patients with osteoporosis. However, there are few reports investigated the influence of denosumab in patients with RA.Objectives:We evaluated the BMD change in patients with RA treated denosumab and assessed the effect of various factors, such as disease activity, biological disease-modifying anti-rheumatic drugs (bDMARDs) use, concomitant medications of osteoporosis and pretreatment of osteoporosis.Methods:This

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Watson, Roger. "Psychotropic Drugs and the Elderly: Fast Facts Joel Sadavoy Psychotropic Drugs and the Elderly: Fast Facts WW Norton & Company Ltd 749 pp £37 0 393 70375 4 0393703754." Nursing Older People 16, no. 6 (2004): 43. http://dx.doi.org/10.7748/nop.16.6.43.s22.

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Procter, Andrew. "Neurotransmitters, Drugs and Brain Function. Edited by R. A. Webster. John Wiley and Sons, Ltd, Chichester, 2001. Pages: 534. £100.00." International Journal of Geriatric Psychiatry 17, no. 11 (2002): 1081–82. http://dx.doi.org/10.1002/gps.742.

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Sapova, K. I., and S. V. Ryazantsev. "Characteristics of the treatment of perennial allergic rhinitis in patients of the older age group." Medical Council, no. 20 (November 14, 2018): 107–10. http://dx.doi.org/10.21518/2079-701x-2018-20-107-110.

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Recent studies show that perennial allergic rhinitis is prevalent among older people, but the management of this disease is underestimated and not determined. This article describes the persistent allergic rhinitis in patients of the older age group and identifies the primary goals of treatment based on the age-related physiological factors, concomitant conditions and the use of other drugs. Special attention is paid to the various options for the drug therapy in elderly patients over the age of 60 years. The second-generation antihistamines and intranasal glucocorticosteroids also have primac

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Rahman, Md Shahinur, Subrata Mondal, and Amir Hossain. "Agrochemicals used in freshwater aquaculture in Jhenaidah district, Bangladesh." Asian-Australasian Journal of Food Safety and Security 3, no. 2 (2019): 63–76. http://dx.doi.org/10.3329/aajfss.v3i2.55931.

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The present experiment was conducted in order to investigate the use of agrochemicals in freshwater aquaculture with emphasis on fish health management. The selected area was Mahespur upazila under Jhenaidah district and the study duration was six months. The main group was fifty fish farmers and the data were collected through interview with fish farmers and key informants (chemical seller). Ten categories of chemicals were identified that are used by fish farmers for various purposes such as pond preparation, water quality management, controlling diseases, supplying oxygen, killing fish pred

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Miyamae, T., Y. Manabe, T. Sugihara, et al. "POS0794 PREGNANCY AND CHILDBIRTH IN TAKAYASU ARTERITIS IN JAPAN – A NATIONWIDE RETROSPECTIVE STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 684–85. http://dx.doi.org/10.1136/annrheumdis-2022-eular.980.

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BackgroundTakayasu arteritis (TAK), a granulomatous large vessel vasculitis, mainly involves the aorta and its proximal branches and commonly occurs in young females. However, studies of pregnancy in women with TAK are sparse and limited, probably due to the rarity of the disease.ObjectivesThe purpose of this study was to understand the status quo of medical treatments of the primary disease and outcomes of pregnancy in patients with TAK, and birth outcomes of the children in Japan.MethodsPatients with TAK who conceived after the onset of the disease and were managed at medical facilities part

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Bari, Sayed Mashequl, Md Naimul Hassan, Kazi Towsif Ahmed, et al. "Aqua drugs and chemicals used in commercial aquaculture in Mymensingh, Bangladesh." Archives of Agriculture and Environmental Science 9, no. 2 (2024): 280–88. http://dx.doi.org/10.26832/24566632.2024.0902011.

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Mymensingh is a division in north-central Bangladesh renowned for its lush landscapes and agricultural productivity, with a strong focus on aquaculture as a key part of its economy. The study was performed to investigate the aqua drugs companies and their products used in commercial aquaculture farms in Mymensingh division. Questionnaire based data were collected from representatives of various aqua drug companies, district and upazila fisheries offices, chemical vendors, farmers, and hatchery owners of the Mymensingh division. The present study found aquaculture practices in Mymensingh rely h

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Agrawal, M. Y., Y. P. Agrawal, A. Pedhavi, G. Hanmante, and K. Sharma. "A Survey on Oral Antidiabetic Drugs available in Market for Non-complicated Diabetic Patients within Ratnagiri Region." International Journal of PharmTech Research 13, no. 4 (2020): 399–409. http://dx.doi.org/10.20902/ijptr.2019.130413.

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Background: This survey was designed to analyze the current oral anti-diabetic drugs prescribed for non-complicated diabetic patients within Ratnagiri region on the basis of variation in prices of same drug available in different brands. Methods: The present survey has been conducted for a period of 4 months involving number of medical stores in Ratnagiri, Maharashtra, Doctors and Patients with randomly evaluating around 650 prescriptions. A standard questionnaire was prepared containing different questions; based on patient’s data (such as age, gender, disease history and medications), Doctor

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Garg, Amit, Anupama R. Singh, Shyamal S. Kadukkatt, Juan Pablo, and Shyam Akku. "Generic dRug Adoption Framework: Framework to assess perceptions and identify high-quality generic drugs in oncology." Journal of Generic Medicines: The Business Journal for the Generic Medicines Sector 15, no. 2 (2019): 69–75. http://dx.doi.org/10.1177/1741134319833122.

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Perceptions in physicians and pharmacists are a common impediment to the utilization of generic medicines in clinical practice. As a multinational initiative to accelerate access to high-quality generic medicines, Dr Reddy’s Laboratories Ltd has developed the Generic dRug Adoption Framework. Currently available in four languages (English, Portuguese, Spanish, and Russian) and four (Malaysia, Brazil, Colombia, and Ukraine) countries, the framework will enable physicians and pharmacists to identify high-quality generics and help towards switching from originator to generic medicines. This can he

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Goto, Emi, Akihiro Tomita, Akihide Atsumi, Hitoshi Kiyoi, and Tomoki Naoe. "Double Genetic Mutations in PML-Rara Fusion Gene Confirmed in a Patient Showing Resistance to All-Trans Retinoic Acid and Arsenic-Trioxide Therapy." Blood 114, no. 22 (2009): 1743. http://dx.doi.org/10.1182/blood.v114.22.1743.1743.

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Abstract Abstract 1743 Poster Board I-769 Background Molecular targeting drugs, all-trans retinoic acid (ATRA)and arsenic trioxide (ATO), have major advances in the treatment of acute promyelocytic leukemia (APL). However, resistance to these drugs has been also observed in clinical practice. ATRA acts as a ligand for retinoic acid receptor alpha (RAR) and restores the aberrant transcription repression by PML-RARA fusion protein in APL cells. Previous reports demonstrate that amino-acids substitution, resulting from genetic mutations, in ligand binding domain (LBD) of RARA region of PML-RARA w

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Yang, Na, Wei Deng, Qiaoling Sun, et al. "HMPL-523, a Novel SYK Inhibitor Showed Anti-Tumor Activities In Vitro and In Vivo." Blood 128, no. 22 (2016): 3970. http://dx.doi.org/10.1182/blood.v128.22.3970.3970.

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Abstract Introduction: Spleen Tyrosine Kinase (SYK), a non-receptor type of tyrosine kinase, is a member of Syk/ZAP70 tyrosine kinase family. It plays a pivotal role in the regulation of B-cell receptor (BCR) signal pathway, which regulates proliferation, differentiation and survival of B lymphocytes. The abnormal activation of BCR singling is closely related to transformation and development of B cell lymphoma. Targeting BCR downstream molecules, such as Bruton' tyrosine kinase (BTK) and phosphoinositide-3-kinase δ (PI3Kδ) has emerged as new therapeutic approaches and inhibitors of BTK and PI

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