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Journal articles on the topic 'Drugs (Synthesis)'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

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1

Moilanen, E., J. Alanko, E. Seppälä, M. Nissilä, H. Isomakp, and H. Vapaatalo. "Antirheumatic drugs and eicosanoid synthesis." Scandinavian Journal of Rheumatology 17, sup67 (1988): 10–16. http://dx.doi.org/10.3109/03009748809105286.

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2

Zhou, Shiyang, and Gangliang Huang. "Synthesis of anti-allergic drugs." RSC Advances 10, no. 10 (2020): 5874–85. http://dx.doi.org/10.1039/c9ra10659f.

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Histamine is formed by the decarboxylation of histidine catalyzed by enzymes. It is an endogenous biologically active substance involved in multiple complex physiological processes as an important chemical transmitter.

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3

Skachilova, S. Ya, G. A. Ermakova, N. K. Zheltukhin, E. F. Zueva, and N. K. Davydova. "DRUGS DEVELOPED AT «ARC BASS» WITH M.D. MASHKOVSKII LEAD (REVIEW)." Drug development & registration 8, no. 1 (2019): 7–13. http://dx.doi.org/10.33380/2305-2066-2019-8-1-7-13.

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Introduction. There are presented data on drugs development with M.D. Mashkovskii lead. There are given materials on drugs belonging to important pharmacotherapeutic groups of drugs such as generic and original drugs. Original syntheses of famous generic drugs and improved industrial technologies have been developed. The attention is paid to high quality of produced drugs. More than 200 new molecules were synthesized while developing original structures of nitrobenzamide derivatives. The studies of pharmacological and toxicological characteristics have helped to choose and create original anti

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4

Ungvarská Maľučká, Lucia, and Jozef Csöllei. "Design, Synthesis and Biological Activity of New Carbamate Cholinesterase Inhibitors." Chemické listy 116, no. 6 (2022): 372–80. http://dx.doi.org/10.54779/chl20220372.

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The work deals with the design, synthesis and biological activity of new carbamate cholinesterase inhibitors. It is focused on selected syntheses of new carbamate derivatives, which were tested for their anticholinesterase activity against acetylcholinesterase as well as butyrylcholinesterase. Despite various theories in the pathogenesis of Alzheimer's disease, drugs that can inhibit these two enzymes still represent the major approach to the treatment of this neurodegenerative disease. Many of the newly synthesized compounds have unique chemical structure. Recently, the approach to the synthe

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5

Menéndez, J., Marco Leonardi, Verónica Estévez, and Mercedes Villacampa. "The Hantzsch Pyrrole Synthesis: Non-conventional Variations and Applications of a Neglected Classical Reaction." Synthesis 51, no. 04 (2018): 816–28. http://dx.doi.org/10.1055/s-0037-1610320.

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Pyrrole is one of the most important one-ring heterocycles because of its widespread presence in natural products and unnatural bioactive compounds and drugs in clinical use. The preparation of pyrroles by reaction between primary amines, β-dicarbonyl compounds, and α-halo ketones, known as the Hantzsch pyrrole synthesis, is reviewed here for the first time. In spite of its age and its named reaction status, this method has received little attention in the literature. Recent work involving the use of non-conventional conditions has rejuvenated this classical reaction and this is emphasized in

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6

Rode, Haridas B., Dhanaji M. Lade, René Grée, Prathama S. Mainkar, and Srivari Chandrasekhar. "Strategies towards the synthesis of anti-tuberculosis drugs." Organic & Biomolecular Chemistry 17, no. 22 (2019): 5428–59. http://dx.doi.org/10.1039/c9ob00817a.

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In this report, we reviewed the strategies towards the synthesis of anti-tuberculosis drugs. They include semisynthetic approaches, resolution based strategies, microbial transformations, solid phase synthesis, and asymmetric synthesis.

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7

Di Filippo, Mara, and Marcus Baumann. "Continuous Flow Synthesis of Anticancer Drugs." Molecules 26, no. 22 (2021): 6992. http://dx.doi.org/10.3390/molecules26226992.

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Continuous flow chemistry is by now an established and valued synthesis technology regularly exploited in academic and industrial laboratories to bring about the improved preparation of a variety of molecular structures. Benefits such as better heat and mass transfer, improved process control and safety, a small equipment footprint, as well as the ability to integrate in-line analysis and purification tools into telescoped sequences are often cited when comparing flow to analogous batch processes. In this short review, the latest developments regarding the exploitation of continuous flow proto

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8

Belikov, V. G., and A. G. Kuregyan. "Synthesis of Magnetite Complexes with Drugs." Pharmaceutical Chemistry Journal 38, no. 3 (2004): 153–56. http://dx.doi.org/10.1023/b:phac.0000034306.33479.4d.

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9

Mandala, Devender, Warren A. Thompson, and Paul Watts. "Synthesis routes to anti-HIV drugs." Tetrahedron 72, no. 24 (2016): 3389–420. http://dx.doi.org/10.1016/j.tet.2016.04.075.

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10

Boldyrev, V. V. "Mechanochemical modification and synthesis of drugs." Journal of Materials Science 39, no. 16/17 (2004): 5117–20. http://dx.doi.org/10.1023/b:jmsc.0000039193.69784.1d.

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11

Mohammed Ali, Firyal, and Wameedh Sameer Sadeq. "Synthesis of Gelatin Graft Itaconic Drugs." International Journal of Applied Chemistry 6, no. 3 (2019): 13–17. http://dx.doi.org/10.14445/23939133/ijac-v6i3p103.

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12

Kuznetsov, S. G., and S. M. Chigareva. "Metabolism and directed synthesis of drugs." Pharmaceutical Chemistry Journal 23, no. 7 (1989): 602–7. http://dx.doi.org/10.1007/bf00764667.

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13

Kolotilov, Nikolay. "Drugs of radiological pharmacology: Quercetin." Radiation Diagnostics, Radiation Therapy, no. 2 (2020): 81–83. http://dx.doi.org/10.37336/2707-0700-2020-2-7.

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The purpose of the article is to draw attention to Quercetin as a means of radiological pharmacology within the framework of medicines’ repurposing. Spectrum of pharmacological activity. Quercetin possesses anti-inflammatory (blockade of the lipoxygenase pathway of arachidonic acid metabolism, decreased synthesis of leukotrienes, serotonin and other inflammatory mediators), antioxidant, antispasmodic, diuretic, membrane stabilizing, capillary stabilizing, regenerative, estrogen-like (effect on proline hydroxylase, inhibition of tumor necrosis factor and synthesis of interleukins), immunomodula

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14

Tarabanko, V. E., M. A. Smirnova та E. G. Zhizhina. "Processes for the synthesis of γ-acetopropyl alcohol". Kataliz v promyshlennosti 22, № 2 (2022): 5–17. http://dx.doi.org/10.18412/1816-0387-2022-2-5-17.

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The literature on the existing processes for the synthesis of γ-acetopropyl alcohol (acetopropanol, 5-hydroxypentan-2-one, APA) is reviewed. This substance is used to produce vitamin B1, antimalarial drugs and polymers. The promising methods for APA production are the hydrogenation-hydration of sylvan (2-methylfuran), hydrogenation of furfural, and syntheses based on allyl acetate, sodium acetoacetic ether, and γ-butyrolactone.

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15

Mahmood Aljamali, Nagham, and . "Review Inchemical Structures of Drugs." International Journal of Engineering & Technology 7, no. 4.36 (2018): 644. http://dx.doi.org/10.14419/ijet.v7i4.36.24216.

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16

Driver, Russell, and Li-Xi Yang. "Synthesis and Pharmacology of New Camptothecin Drugs." Mini-Reviews in Medicinal Chemistry 5, no. 5 (2005): 425–39. http://dx.doi.org/10.2174/1389557053765547.

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17

Hsieh-Wilson, L. C., and M. E. Griffin. "Improving Biologic Drugs via Total Chemical Synthesis." Science 342, no. 6164 (2013): 1332–33. http://dx.doi.org/10.1126/science.1247615.

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18

Mirafzal, Gholam A., and Jolene M. Summer. "Microwave Irradiation Reactions: Synthesis of Analgesic Drugs." Journal of Chemical Education 77, no. 3 (2000): 356. http://dx.doi.org/10.1021/ed077p356.

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19

Alcántara, Cristina M., and Andrés R. Alcántara. "Biocatalyzed synthesis of antidiabetic drugs: A review." Biocatalysis and Biotransformation 36, no. 1 (2017): 12–46. http://dx.doi.org/10.1080/10242422.2017.1323887.

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20

Moura, Matthew, Justin Finkle, Sarah Stainbrook, Jennifer Greene, Linda J. Broadbelt, and Keith E. J. Tyo. "Evaluating enzymatic synthesis of small molecule drugs." Metabolic Engineering 33 (January 2016): 138–47. http://dx.doi.org/10.1016/j.ymben.2015.11.006.

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21

Moutevelis-Minakakis, P., M. Gianni, H. Stougiannou, et al. "Design and synthesis of novel antihypertensive drugs." Bioorganic & Medicinal Chemistry Letters 13, no. 10 (2003): 1737–40. http://dx.doi.org/10.1016/s0960-894x(03)00251-8.

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22

Service, Robert F. "'Awesome' Synthesis Could Boost Protein-Based Drugs." Science 338, no. 6103 (2012): 28. http://dx.doi.org/10.1126/science.338.6103.28.

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23

Kaspersen, Frans M., Jan F. Vader, Carel W. Funke, and Eric M. G. Sperling. "Synthesis and characterization of isotopically labelled drugs." Recueil des Travaux Chimiques des Pays-Bas 112, no. 2 (2010): 191–99. http://dx.doi.org/10.1002/recl.19931120218.

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24

Margolin, Alexey L. "Enzymes in the synthesis of chiral drugs." Enzyme and Microbial Technology 15, no. 4 (1993): 266–80. http://dx.doi.org/10.1016/0141-0229(93)90149-v.

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25

SCOTT, J. W. "ChemInform Abstract: Synthesis of Enantiomerically Pure Drugs." ChemInform 24, no. 49 (2010): no. http://dx.doi.org/10.1002/chin.199349295.

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26

Douglas, Kenneth T. "The thymidylate synthesis cycle and anticancer drugs." Medicinal Research Reviews 7, no. 4 (1987): 441–75. http://dx.doi.org/10.1002/med.2610070405.

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27

Lin, Guo-Qiang, and Xing-Wen Sun. "ChemInform Abstract: Chiral Drugs Through Asymmetric Synthesis." ChemInform 43, no. 21 (2012): no. http://dx.doi.org/10.1002/chin.201221233.

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28

Liu, Zoe S. J., Trang T. T. Truong, Chiara C. Bortolasci, et al. "Effects of Psychotropic Drugs on Ribosomal Genes and Protein Synthesis." International Journal of Molecular Sciences 23, no. 13 (2022): 7180. http://dx.doi.org/10.3390/ijms23137180.

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Altered protein synthesis has been implicated in the pathophysiology of several neuropsychiatric disorders, particularly schizophrenia. Ribosomes are the machinery responsible for protein synthesis. However, there remains little information on whether current psychotropic drugs affect ribosomes and contribute to their therapeutic effects. We treated human neuronal-like (NT2-N) cells with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM) or vehicle control for 24 h. Transcriptomic an

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29

Scheeff, Stephan, and Dirk Menche. "Total syntheses of the archazolids: an emerging class of novel anticancer drugs." Beilstein Journal of Organic Chemistry 13 (June 7, 2017): 1085–98. http://dx.doi.org/10.3762/bjoc.13.108.

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V-ATPase has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with the archazolids, complex polyketide macrolides which present the most potent V-ATPase inhibitors known to date, rendering these macrolides important lead structures for the development of novel anticancer agents. The limited natural supply of these metabolites from their myxobacterial source renders total synthesis of vital importance for the further preclinical development. This review describes in detail the various tactics and strategies employed so far in archazolid syn

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30

GUTTERIDGE, W. E. "Designer drugs: pipe-dreams or realities?" Parasitology 114, no. 7 (1997): 145–51. http://dx.doi.org/10.1017/s0031182097008998.

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New chemotherapies are urgently needed for the parasitic infections of animals and for the tropical diseases of man. Rational molecular design approaches to attempt to discover such products require a massive investment of resources up-front of actual chemical synthesis. However, such investment is justified, since chemical synthesis itself is highly resource-consuming. The fact that few targets have yet been validated to justify a rational approach is an argument only to get on and validate more. Not all the components of molecular design can yet be done totally rationally, but this is not an

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31

Aziz Alibeg, Ammar Abdul. "Synthesis of Mutual Pro-drugs through coupling of Etodolac And Tolmetin by Sulfa drugs." American Journal of PharmTech Research 8, no. 1 (2018): 336–42. http://dx.doi.org/10.46624/ajptr.2018.v8.i1.024.

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32

Hamasaki, Yuhe, Tomohiro Ichimaru, and Sumio Miyazaki. "INHIBITION OF LTB4 SYNTHESIS BY ANTI-ALLERGIC DRUGS." Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 1, no. 2 (1987): 44–47. http://dx.doi.org/10.3388/jspaci.1.2_44.

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33

Dhanawat, Meenakshi, and Sushant Shrivastava. "Solid-Phase Synthesis of Oligosaccharide Drugs: A Review." Mini-Reviews in Medicinal Chemistry 9, no. 2 (2009): 169–85. http://dx.doi.org/10.2174/138955709787316083.

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34

Ruiz-Herrera, J., and G. San-Blas. "Chitin Synthesis as a Target for Antifungal Drugs." Current Drug Target -Infectious Disorders 3, no. 1 (2003): 77–91. http://dx.doi.org/10.2174/1568005033342064.

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35

Pendri, Annapurna, Carl W. Gilbert, Soundara Soundararajan, Durgadas Bolikal, Robert G. L. Shorr, and Richard B. Greenwald. "PEG Modified Anticancer Drugs: Synthesis and Biological Activity." Journal of Bioactive and Compatible Polymers 11, no. 2 (1996): 122–34. http://dx.doi.org/10.1177/088391159601100204.

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36

Schreiber, S. L. "Organic synthesis toward small-molecule probes and drugs." Proceedings of the National Academy of Sciences 108, no. 17 (2011): 6699–702. http://dx.doi.org/10.1073/pnas.1103205108.

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37

Nagiec, M. Marek, Elzbieta E. Nagiec, Julie A. Baltisberger, Gerald B. Wells, Robert L. Lester, and Robert C. Dickson. "Sphingolipid Synthesis as a Target for Antifungal Drugs." Journal of Biological Chemistry 272, no. 15 (1997): 9809–17. http://dx.doi.org/10.1074/jbc.272.15.9809.

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38

Uhrig, Rainer K., Martin A. Picard, Konrad Beyreuther, and Manfred Wiessler. "Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates." Carbohydrate Research 325, no. 1 (2000): 72–80. http://dx.doi.org/10.1016/s0008-6215(99)00311-0.

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39

Böttger, Erik C. "Resistance to drugs targeting protein synthesis in mycobacteria." Trends in Microbiology 2, no. 10 (1994): 416–21. http://dx.doi.org/10.1016/0966-842x(94)90622-x.

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40

Liew, Siong, and Li-Xi Yang. "Design, Synthesis and Development of Novel Camptothecin Drugs." Current Pharmaceutical Design 14, no. 11 (2008): 1078–97. http://dx.doi.org/10.2174/138161208784246180.

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41

Marcia de Figueiredo, Renata, and Mathias Christmann. "Organocatalytic Synthesis of Drugs and Bioactive Natural Products." European Journal of Organic Chemistry 2007, no. 16 (2007): 2575–600. http://dx.doi.org/10.1002/ejoc.200700032.

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42

Yudelevich, V. I., M. A. Shneider, V. V. Belakhov, et al. "Synthesis of potential drugs based on hydrophosphoryl compounds." Pharmaceutical Chemistry Journal 19, no. 11 (1985): 780–88. http://dx.doi.org/10.1007/bf00766633.

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43

Benaglia, Maurizio, Mauro Cinquini, and Franco Cozzi. "ChemInform Abstract: Stereoselective Synthesis of Enantiomerically Pure Drugs." ChemInform 32, no. 2 (2001): no. http://dx.doi.org/10.1002/chin.200102261.

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44

Nagase, Hiroshi, Akio Watanabe, Toru Nemoto, et al. "Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons." Bioorganic & Medicinal Chemistry Letters 21, no. 13 (2011): 4023–26. http://dx.doi.org/10.1016/j.bmcl.2011.04.134.

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45

Roy, Gouriprasanna, and G. Mugesh. "Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions." Bioinorganic Chemistry and Applications 2006 (2006): 1–9. http://dx.doi.org/10.1155/bca/2006/23214.

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Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the selenenyl iodide intermediate (E-SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone s

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46

Kletskov, Alexey V., Nikolay A. Bumagin, Fedor I. Zubkov, Dmitry G. Grudinin, and Vladimir I. Potkin. "Isothiazoles in the Design and Synthesis of Biologically Active Substances and Ligands for Metal Complexes." Synthesis 52, no. 02 (2019): 159–88. http://dx.doi.org/10.1055/s-0039-1690688.

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The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. Some representatives of isothiazoles have proven to be synergists of bioactive substances, which opens the way to lower the doses of drugs used and is especially important in cancer chemotherapy. In the framework of the present review, the accomplishments in the chemistry of isothiazoles over the past 18 year

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47

Mishra, Vaibhav, and Tejpal Singh Chundawat. "Pd Catalyzed N1/N4 Arylation of Piperazine for Synthesis of Drugs, Biological and Pharmaceutical Targets: An Overview of Buchwald Hartwig Amination Reaction of Piperazine in Drug Synthesis." Current Organic Synthesis 15, no. 2 (2018): 208–20. http://dx.doi.org/10.2174/1570179415666171206151603.

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Background: Substituted piperazine heterocycles are among the most significant structural components of pharmaceuticals. N1/N4 substituted piperazine containing drugs and biological targets are ranked 3rd in the top most frequent nitrogen heterocycles in U.S. FDA approved drugs. The high demand of N1/N4 substituted piperazine containing biologically active compounds and U.S. FDA approved drugs, has prompted the development of Pd catalyzed C-N bond formation reactions for their synthesis. Buchwald-Hartwig reaction is the key tool for the synthesis of these compounds. Objective: This review prov

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48

Curry, Stephen L., Steven M. Cogar, and James L. Cook. "Nonsteroidal Antiinflammatory Drugs: A Review." Journal of the American Animal Hospital Association 41, no. 5 (2005): 298–309. http://dx.doi.org/10.5326/0410298.

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The increasing use of nonsteroidal antiinflammatory drugs (NSAIDs) in small animals has resulted in the development of new and innovative additions to this class of drugs. Examples of NSAIDs now available for use in small animals include aspirin, etodolac, carprofen, ketoprofen, meloxicam, deracoxib, and tepoxalin. The purposes of this article are to review the pathophysiology of prostaglandin synthesis and inhibition, the mechanisms of action, pharmacokinetics, pharmacological effects, and potential adverse reactions of aspirin and the newly released NSAIDs.

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49

Wilmańska, Dorota, Malgorzata Czyz, Kazimierz Studzian, Mariola K. Piestrzeniewicz, and Marek Gniazdowski. "Effects of Anticancer Drugs on Transcription in vitro." Zeitschrift für Naturforschung C 56, no. 9-10 (2001): 886–91. http://dx.doi.org/10.1515/znc-2001-9-1034.

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AbstractThe effects of DNA interacting drugs on: (1) total RNA synthesis catalyzed by E.coli and T7 RNA polymerase; (2) synthesis of the initiating dinucleotide (pppApU) by E .coli RNA polymerase (“abortive initiation“); (3) elongation of RNA chains synthesized by T7 RNA polymerase on pT7-7 plasmid DNA bearing T7 RNA polymerase promoter ϕ 10 with human Cu/Zn superoxide dismutase coding sequence, (4) interaction of transcription factor Sp1 and its binding site were studied. Intercalating ligands which form quickly dissociating complexes with DNA (anthracyclines, proflavine, ethidium bromide) ar

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50

Tamatam, Rekha, and Dongyun Shin. "Asymmetric Synthesis of US-FDA Approved Drugs over Five Years (2016–2020): A Recapitulation of Chirality." Pharmaceuticals 16, no. 3 (2023): 339. http://dx.doi.org/10.3390/ph16030339.

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Chirality is a major theme in the design, discovery, and development of new drugs. Historically, pharmaceuticals have been synthesized as racemic mixtures. However, the enantiomeric forms of drug molecules have distinct biological properties. One enantiomer may be responsible for the desired therapeutic effect (eutomer), whereas the other may be inactive, interfere with the therapeutic form, or exhibit toxicity (distomer). Classical chemical synthesis usually leads to a racemic mixture unless stereospecific synthesis is employed. To meet the requirements of single-enantiomeric drugs, asymmetri

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